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See detailPauvreté et mortalité différentielle chez les personnes âgées
Lefebvre, Mathieu ULg; Pestieau, Pierre ULg; Ponthiere, Grégory ULg

in Reflets et Perspectives de la Vie Economique (2011), L(4), 45-54

Cette note a pour objectif d’illustrer, dans le cas de la Belgique et de ses régions, un problème particulier posé par la mesure de la pauvreté. Etant donné que la mortalité varie selon le niveau de ... [more ▼]

Cette note a pour objectif d’illustrer, dans le cas de la Belgique et de ses régions, un problème particulier posé par la mesure de la pauvreté. Etant donné que la mortalité varie selon le niveau de revenu – les personnes aux revenus plus élevés vivant plus longtemps, en moyenne, que les personnes aux revenus plus faibles – les taux de pauvreté calculés pour les classes âgées dépendent non seulement de ce que l’on pourrait appeler la vraie pauvreté, mais aussi de la sélection induite par la mortalité différentielle selon le revenu. En calculant les taux de pauvreté que l’on observerait si des personnes avec différents niveaux de revenus avaient toutes la même espérance de vie, on peut ainsi estimer la vraie pauvreté, en neutralisant les interférences dues à la mortalité différentielle. Cet ajustement des mesures de pauvreté est particulièrement intéressant pour la Belgique, où les écarts de longévité entre Flamands et Francophones et entre riches et moins riches sont importants. [less ▲]

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See detailCan environmental and socio-economic factors explain the recent emergence of Rift Valley Fever in Yemen, 2000-2001?
Abdo-Salem, S.; Tran, A.; Grosbois, V. et al

in Vector Borne & Zoonotic Diseases (2011), 11

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See detailBrain functional integration decreases during propofol-induced loss of consciousness.
Schrouff, Jessica ULg; Perlbarg, Vincent; Boly, Mélanie ULg et al

in NeuroImage (2011), 57(1), 198-205

Consciousness has been related to the amount of integrated information that the brain is able to generate. In this paper, we tested the hypothesis that the loss of consciousness caused by propofol ... [more ▼]

Consciousness has been related to the amount of integrated information that the brain is able to generate. In this paper, we tested the hypothesis that the loss of consciousness caused by propofol anesthesia is associated with a significant reduction in the capacity of the brain to integrate information. To assess the functional structure of the whole brain, functional integration and partial correlations were computed from fMRI data acquired from 18 healthy volunteers during resting wakefulness and propofol-induced deep sedation. Total integration was significantly reduced from wakefulness to deep sedation in the whole brain as well as within and between its constituent networks (or systems). Integration was systematically reduced within each system (i.e., brain or networks), as well as between networks. However, the ventral attentional network maintained interactions with most other networks during deep sedation. Partial correlations further suggested that functional connectivity was particularly affected between parietal areas and frontal or temporal regions during deep sedation. Our findings suggest that the breakdown in brain integration is the neural correlate of the loss of consciousness induced by propofol. They stress the important role played by parietal and frontal areas in the generation of consciousness. [less ▲]

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See detailRecherche sur la gestion des âges dans les entreprises belges
Hansez, Isabelle ULg; Faulx, Daniel ULg; Angenot, Arnaud ULg et al

Report (2011)

Face à la problématique du vieillissement au travail, ainsi qu’aux conséquences sociales et économiques auxquelles elle est associée, la nécessité de mettre en place une gestion des âges au sein des ... [more ▼]

Face à la problématique du vieillissement au travail, ainsi qu’aux conséquences sociales et économiques auxquelles elle est associée, la nécessité de mettre en place une gestion des âges au sein des entreprises est de plus en plus souvent mise en exergue. Cette gestion des âges, qui se veut intégrée, implique cependant une remise en question profonde des valeurs, des normes et de la culture d’entreprise. Associer le facteur « âge » aux politiques et pratiques de ressources humaines doit nécessairement s’accompagner d’un changement des mentalités et d’une meilleure intégration des générations au travail. C’est dans cette optique qu’une recherche sur la gestion des âges dans les entreprises belges a été commanditée, en 2010, par le Service Public Fédéral Emploi, Travail et Concertation sociale. Cette recherche a contribué au développement d’un guide de sensibilisation dont l’objectif était de constituer une aide à l’implémentation d’une gestion des âges efficace en entreprise. [less ▲]

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See detailCharacterization of the response of GFP microbial biosensors sensitive to substrate limitation in scale-down bioreactors
Delvigne, Frank ULg; Brognaux, Alison ULg; Gorret, Nathalie et al

in Biochemical Engineering Journal (2011), 55(2), 131-139

The dynamics of microbial stress response in intensive cultivation conditions remains not completely understood. In this work, two green fluorescent protein (GFP) transcriptional reporters have been used ... [more ▼]

The dynamics of microbial stress response in intensive cultivation conditions remains not completely understood. In this work, two green fluorescent protein (GFP) transcriptional reporters have been used as biosensors of the heterogeneities generated in a two-compartment scale-down reactor. The stress promoters have been chosen for their responsiveness to carbon limitation corresponding to the global substrate profiles encountered in intensive fed-batch cultures. From our results, it can be concluded that the exposure of microbial cells to substrates heterogeneities tends to decrease the GFP expression level in fed-batch mode. Fluorescence intensities have been monitored at the single cell level by using flow cytometry. During the course of the fed-batch culture, a drop at the level of the intracellular GFP content has been observed for the two scale-down operating conditions and for the two promoters sensitive to substrate limitation (rpoS and csiE). The fluorescence drop can be attributed to the repression of these promoters but also to the release of GFP to the extracellular medium according to the increase of the fluorescence level of the supernatant. This leakage has been observed for all the operating conditions, i.e. the scale-down reactors and the culture operating in the normal mode, i.e. in a well-mixed bioreactor. Interestingly, GFP leakage is more pronounced in the case of the cultures operated in the normal mode. Indeed, staining by propidium iodide tends to be more elevated for the microbial cells cultured under the normal mode by comparison with those cultured in scale-down conditions, indicating a higher permeability of the membrane. These results suggest that GFP microbial biosensors could be used to detect simultaneously mixing imperfections and their impact on the viability of microorganisms. [less ▲]

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See detailContrôle de Tetranychus urticae par les extraits de plantes en vergers d'agrumes
Attia, Sabrine; Grissa, Kaouthar Lebdi; Ghrabi-Gammar, Zeineb et al

in Entomologie Faunistique = Faunistic Entomology (2011), 63(4), 229-235

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See detailA non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises
Weijs, Liesbeth; Covaci, Adrian; Yang, Raymond S. H. et al

in Toxicology and Applied Pharmacology (2011), 256

In the last decade, physiologically based pharmacokinetic (PBPK) models have increasingly been developed to explain the kinetics of environmental pollutants in wildlife. For marine mammals specifically ... [more ▼]

In the last decade, physiologically based pharmacokinetic (PBPK) models have increasingly been developed to explain the kinetics of environmental pollutants in wildlife. For marine mammals specifically, these models provide a new, non-destructive tool that enables the integration of biomonitoring activities and in vitro studies. The goals of the present study were firstly to develop PBPK models for several environmental relevant PCB congeners in harbor porpoises (Phocoena phocoena), a species that is sensitive to pollution because of its limited metabolic capacity for pollutant transformation. These models were tested using tissue data of porpoises from the Black Sea. Secondly, the predictive power of the models was investigated for time trends in the PCB concentrations in North Sea harbor porpoises between 1990 and 2008. Thirdly, attempts were made to assess metabolic capacities of harbor porpoises for the investigated PCBs. In general, results show that parameter values from other species (rodents, humans) are not always suitable in marine mammal models, most probably due to differences in physiology and exposure. The PCB 149 levels decrease the fastest in male harbor porpoises from the North Sea in a time period of 18†years, whereas the PCB 101 levels decrease the slowest. According to the models, metabolic breakdown of PCB 118 is probably of lesser importance compared to other elimination pathways. For PCB 101 and 149 however, the presence of their metabolites can be attributed to bioaccumulation of metabolites from the prey and to metabolic breakdown of the parent compounds in the harbor porpoises. [less ▲]

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See detailRaconter le paysage de la recherche
Mougenot, Catherine ULg

Book published by QUAE (2011)

C’est à un voyage à l’intérieur de la recherche que nous convie Catherine Mougenot, hors des sentiers battus des évaluations, des acquis et des résultats chiffrés. L’aventure commence à l’occasion du ... [more ▼]

C’est à un voyage à l’intérieur de la recherche que nous convie Catherine Mougenot, hors des sentiers battus des évaluations, des acquis et des résultats chiffrés. L’aventure commence à l’occasion du programme de recherche «Action publique, agriculture et biodiversité» rassemblant une communauté très large de chercheurs de terrain : écologues, agronomes, sociologues, géographes, économistes, politiciens, anthropologues, juristes, vétérinaires, toxicologues, qui ont tous accepté la confrontation des disciplines et ce qu’elle implique d’atermoiements, de négociations, de renoncements. Le programme n’est que prétexte à une démarche réflexive dans laquelle l’auteur entraîne les acteurs de la recherche. L’ouvrage prend l’allure de récits où la dimension sensible devient essentielle, ce qui ne veut pas dire que leur travail n’est pas scientifique, mais témoigne de la présence déterminante de cette dimension, au même titre que la passion qui vibre à travers leurs paroles. L’ouvrage devient alors l’histoire des liens de cette communauté, une vision du vécu des chercheurs en regard de quelques grandes questions : la biodiversité, le terrain, l’interdisciplinarité, l’action. Tout au long de cette collecte de récits, Catherine Mougenot s’est efforcée en intervenant le moins possible de ne pas trahir les acteurs. Son écriture à chaud colle à l’expérience, jusqu’au moment où, du travail de montage de ces « histoires », l’auteur tire une analyse très pointue des propriétés du récit. Destiné à la communauté scientifique, cet ouvrage s’adresse également à tous ceux qui vivent la passion de la recherche comme une mise en intrigue. [less ▲]

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See detailAqueous and non-aqueous sol-gel preparation of TiO2 films for the photocatalytic oxidation of ethanol in air
Cimieri, Iolanda; Poelman, Hilde; Lambert, Stéphanie ULg et al

Poster (2011)

One of the most versatile methods to prepare TiO2 fine powders and films is the sol-gel technique. It offers many advantages, among which the possibility to control the stoichiometry, work in mild and ... [more ▼]

One of the most versatile methods to prepare TiO2 fine powders and films is the sol-gel technique. It offers many advantages, among which the possibility to control the stoichiometry, work in mild and ambient atmospheric conditions and achieve high purity and homogeneity of the final product. Stable TiO2 sols were synthesized by an aqueous sol-gel process using titanium tetraisopropoxide (TTIP) as precursor and nitric acid in water as hydrolyzing agent. The aim of the present study was to investigate the influence of different solvents and different amounts of HNO3 on the photocatalytic activity of TiO2 in the breakdown of ethanol (EtOH) as VOC molecule under UV and visible light. In particular, ethanol, isopropanol and butanol were used as solvents and two different molar ratios of HNO3 with respect to TTIP (0.25 and 0.5 respectively) were used. Their effect was investigated with regard to the photocatalytic properties of the films obtained by spin coating on sodium free glass [1] and heat treated at 450°C in air. The microstructure, optical and morphological properties of the films were investigated using SEM, UV-Vis spectroscopy and ellipsometry. The nature of the crystalline phases was ascertained by X-ray diffraction and the surface area of the powders was measured by N2 adsorption. The porous TiO2 films obtained show quite good photocatalytic activity for the degradation of EtOH compared to titania films prepared using P25 Degussa as shown in Fig. 1. Further the photocatalytic properties of the thin films obtained by aqueous sol-gel method were compared with the activity of films prepared using the same titanium precursor by a non-aqueous sol-gel process, in which the hydrolysis is initialized by esterification reaction between acetic acid and alcohol. (Fig.1. EtOH degradation for P25 (green), non aqueous sol (purple) and aqueous sols prepared using ethanol as solvent and HNO3 in molar ratios 0.25(blue) and 0.50(red)) [1] H. Tomaszewski, K. Eufinger, H. Poelman, D. Poelman, R. De Gryse, P.F.Smet, G.B. Marin, Int. J. Photoenergy 8, 1 (2007) [less ▲]

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See detailLe mécénat féminin en France et en Bourgogne (XVe-XVIe siècles). Nouvelles perspectives. Actes de la journée d'études internationale tenue à l'Université de Liège, le 10 mai 2010
Fagnart, Laure ULg; L'Estrange, Elizabeth

Book published by De Boeck (2011)

Le rôle joué par les femmes de pouvoir au Moyen Âge et au tout début de la Renaissance dans la commande d’œuvres artistiques et culturelles constitue un champ de recherche de plus en plus prolifique. La ... [more ▼]

Le rôle joué par les femmes de pouvoir au Moyen Âge et au tout début de la Renaissance dans la commande d’œuvres artistiques et culturelles constitue un champ de recherche de plus en plus prolifique. La présente collection d’articles, suscitée par une journée d’études intitulée "Le mécénat féminin en France et en Bourgogne (XVe-XVIe siècles). Nouvelles perspectives", qui a eu lieu à l’Université de Liège en 2010, illustre l’importance des femmes mécènes, en France et en Bourgogne, dans les domaines de l’architecture, de l’orfèvrerie, des manuscrits enluminés, de la peinture et de la sculpture, ainsi que dans la traduction et dans l’organisation des cérémonials. Dans leurs fonctions respectives, celles de reine, reine mère, duchesse, régente, dame d’honneur, les femmes font usage des œuvres d’art et des rites pour promouvoir leurs intérêts personnels et dynastiques, confrontées qu’elles sont aux difficultés liées à leur sexe et à leur statut de femme de pouvoir, ou à des difficultés telles que les rivalités, la guerre, ou la folie. Même s’il est clair que les cours française et bourguignonne constituent l’espace le plus favorable à l’efflorescence du mécénat féminin, cette collection démontre toutefois l’existence d’un même phénomène, important, en dehors des sphères royales. [less ▲]

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See detailDrospirenone and interference with renin-antiotensin system
VROONEN, Laurent ULg; Cavalier, Etienne ULg; Vranken, Laura ULg et al

in Annales d'Endocrinologie - 28ème congrès de la société Française d'Endocrinologie (2011)

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See detailObliged permanent pastures : main future of ruminant production in Belgium
Stilmant, Didier; Stassart, Pierre M ULg; Peeters, Pierre et al

in Grassland Science in Europe (2011), 16

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See detailImpact of chronic graft-versus-host disease (GVHD) after reduced intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) as treatment for acute myeloid leukemia (AML) : a survey from the Acute Leukemia Working Party of the EBMT
Baron, Frédéric ULg; Labopin, Myriam; Niederwieser, Dietger et al

in Blood (2011), 118

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients ... [more ▼]

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients (pts) who experienced chronic GVHD after RIC allo-SCT versus in those who did not. Here, we investigated the impact of occurrence of GVHD on transplantation outcomes in a large cohort of AML pts given allogeneic PBSC after RIC conditioning. Data from 1859 AML pts in first (n=1439) or second (n=420) CR transplanted between 2000 and 2009 following a RIC regimen at EBMT affiliated centres were analyzed. Pts were given PBSC from HLA-identical sibling (MRD, n=1208), or from HLA-matched unrelated donors (MUD, n=651). Median pt age at transplantation was 56 y (range, 18–77). 338 male pts were given grafts from female donors. RIC was based on low-dose TBI in 520 (28%) pts, while the remaining pts received chemotherapy-based RIC. ATG was given in 269 (22%) MRD and in 267 (41%) MUD recipients, respectively, while 151 (13%) MRD and 165 (25%) MUD recipients received in-vivo T cell depletion with alemtuzumab. The impact of chronic GVHD on relapse risk, non-relapse mortality (NRM), leukemia-free survival (LFS), and overall survival (OS) was assessed using time-dependent multivariate Cox models and in a landmark analysis at 18 months after transplant. Three-year incidences of relapse, NRM, LFS and OS were 34±1%, 15±1%, 51±2% and 60±2% in MRD recipients, respectively, and 34±2% (p=NS), 24±2% (P<0.001), 42±2% (P=0.001) and 47±2% (P=0.001) in MUD recipients, respectively. Grade II, III and IV acute GVHD were observed in 133 (11%), 61 (5%) and 30 (2%) MRD recipients and in 119 (18%), 41 (6%) and 24 (4%) MUD recipients, respectively. The 3-y cumulative incidence of chronic GVHD was 47%. Fifty-three percent of patients with chronic GVHD had extensive chronic GVHD, while the remaining 47% had limited chronic GVHD. In multivariate analyses, occurrence of grade II-IV acute GVHD was associated with a lower risk of relapse (HR=0.8; P=0.04), a higher risk of chronic (HR=2.2; P<0.001) and extensive chronic GVHD (HR=2.8; P<0.001), a higher risk of NRM (HR=2.4 P<0.001), a worsened LFS (HR=1.3; P=0.01), and a worsened OS (HR=1.5; P<0.001). In multivariate time-dependent analyses, occurrence of limited chronic GVHD was associated with a lower risk of relapse (HR=0.7; P=0.05), comparable NRM (HR=1.4; P=0.16), comparable LFS (HR=0.9; P=0.29) and better OS (HR=0.5; P<0.001), while occurrence of extensive chronic GVHD was associated with a lower risk of relapse (HR=0.6; P=0.01), higher NRM (HR=3.2; P<0.001), a trend for worsened LFS (HR=1.3; P=0.06) and comparable OS (HR=0.9; P=0.34). The median interval from transplantation to occurrence of chronic GVHD was 163 (range, 100–1545) days. To further assess the graft-versus-leukemia effect of chronic GVHD, we performed a landmark analysis in patients who were leukemia-free at 18 months after transplantation (n=776). Median follow-up from this landmark time-point was 24 (range, 0.1–112) months. Two-year relapse, NRM, LFS and OS were 16±2%, 2.5±1%, 82±2%, and 89±2%, respectively, in patients without chronic GVHD before the landmark time-point, versus 9±1% (P=0.001), 8±1% (P<0.001), 83±2% (P=0.65), and 86±2% (P=0.38), respectively, in patients with chronic GVHD before the landmark time-point.In conclusion, in this cohort of AML patients transplanted in remission, occurrence of chronic GVHD was associated with a lower risk of relapse that translated to better OS in patients with limited chronic GVHD but not in those with extensive chronic GVHD who experienced higher long term NRM, highlighting the need for long term prospective assessment of long term effects and quality of life in patients receiving RIC allo-SCT. [less ▲]

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See detailActors' benefit analysis on value chain of fresh dairy milk in Vietnam
Tran Huu; Bui, Thi Nga ULg

in Journal of Economics & Development (2011), (169(II)), 32-38

Vietnam locates in the Asia-the most active region, where gains the highest economic growth rate and highest milk consumption in the world. Vietnam also ranks the second among the highest milk ... [more ▼]

Vietnam locates in the Asia-the most active region, where gains the highest economic growth rate and highest milk consumption in the world. Vietnam also ranks the second among the highest milk productivity in the Asia and milk consumption is increasing rapidly. However, the dairy industry in Vietnam is currently able to meet only 22% of domestic demand; the remaining amount has been imported (VOV/VNA, 2008). In addition, raw milk price is very low while retail price is too high. It leads to low effective in the production of the whole chain. This paper is based on the value chain approach within both quantitative and qualitative methods to evaluate a typical fresh value chain in the North of Vietnam in (Moc Chau platation) in 2008 - 2010. The findings show that the dairy plant is the most powerful actor in the chain and it drives the whole chain while power of dairymen is very weak. The value added of the chain is distributed unequally among its actors in whom more benefitable for non-dairy cow producers. In particular, the value added in dairy cow stage would be much lower. [less ▲]

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See detailHier, da und dort - regionale Variation und standardsprachlicher Gebrauch bei den primären Lokaldeiktika im Deutschen
Möller, Robert ULg

in Zeitschrift für Germanistische Linguistik (2011), 39(2011), 1-23

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See detailEtude de l'activité antifongique des bactéries lactiques isolées de produits alimentaires fermentés et caractérisation de leurs métabolites inhibiteurs
Ndagano, Dora ULg

Doctoral thesis (2011)

Summary: The aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for ... [more ▼]

Summary: The aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for biopreservation. Antifungal activity of these LAB were assessed in MRS solid medium against food spoilage moulds as Aspergillus niger MUCL 28699, Aspergillus niger CWBIF194, Aspergillus tubingensis MP1 and Penicillium crustosum MY1. Three strains, Lactobacillus plantarum VE56, Weissella cibaria FMF4B16 and Weissella paramesenteroides LC11 were selected among 116 for their strongest inhibitory activity and their broad inhibitory spectrum against food moulds. The 4-fold concentrated supernatant of L. plantarum VE56 and W. paramesenteroides LC11 had the strongest inhibitory activity to compare to W. cibaria FMF4B16. The antifungal activity of the cell-free supernatant was pH dependent and insensitive to proteolytic enzymes action suggesting that the inhibitory activity was due to other compounds than proteins. The identification of antifungal compounds by chromatographic studies highlighted the production of phenyllactic acid by the three strains. In addition, 2-hydroxy-3-methylpentanoic acid and 2-hydroxy-4-methylpentanoic acid were produced by L. plantarum VE56 and W. paramesenteroides LC11. However, the concentration assessed in the supernatant was lower than the minimal inhibitory concentration showing a synergic action of all these produced compounds. The effect of the antifungal supernatant of L. plantarum VE56 and W. paramesenteroides LC11 on Aspergillus flavus NRRL 3357 resulted to an inhibition of conidial development and aflatoxin B1 production which was reflected in decreased gene expression of brlA (conidiophore specific transcription factor) and laeA (global regulator of secondary metabolism). These two bacteria also delayed Penicillium expansum MUCL 14498 conidial development in bread. [less ▲]

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See detailDigressions politiques autour de la technique du passe-muraille
Brausch, Géraldine ULg

in Libert, Cédric (Ed.) Espèces d’architecte. Wallonie-Bruxelles (2011)

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