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See detailControl of hydrogen photoproduction by the proton gradient generated by cyclic electron flow in Chlamydomonas reinhardtii.
Tolleter, Dimitri; Ghysels, Bart ULg; Alric, Jean et al

in Plant Cell (2011), 23(7), 2619-30

Hydrogen photoproduction by eukaryotic microalgae results from a connection between the photosynthetic electron transport chain and a plastidial hydrogenase. Algal H(2) production is a transitory ... [more ▼]

Hydrogen photoproduction by eukaryotic microalgae results from a connection between the photosynthetic electron transport chain and a plastidial hydrogenase. Algal H(2) production is a transitory phenomenon under most natural conditions, often viewed as a safety valve protecting the photosynthetic electron transport chain from overreduction. From the colony screening of an insertion mutant library of the unicellular green alga Chlamydomonas reinhardtii based on the analysis of dark-light chlorophyll fluorescence transients, we isolated a mutant impaired in cyclic electron flow around photosystem I (CEF) due to a defect in the Proton Gradient Regulation Like1 (PGRL1) protein. Under aerobiosis, nonphotochemical quenching of fluorescence (NPQ) is strongly decreased in pgrl1. Under anaerobiosis, H(2) photoproduction is strongly enhanced in the pgrl1 mutant, both during short-term and long-term measurements (in conditions of sulfur deprivation). Based on the light dependence of NPQ and hydrogen production, as well as on the enhanced hydrogen production observed in the wild-type strain in the presence of the uncoupling agent carbonyl cyanide p-trifluoromethoxyphenylhydrazone, we conclude that the proton gradient generated by CEF provokes a strong inhibition of electron supply to the hydrogenase in the wild-type strain, which is released in the pgrl1 mutant. Regulation of the trans-thylakoidal proton gradient by monitoring pgrl1 expression opens new perspectives toward reprogramming the cellular metabolism of microalgae for enhanced H(2) production. [less ▲]

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See detailQuercetin inhibits a large panel of kinases implicated in cancer cell biology.
Boly, Rainatou; Gras, Thierry; Lamkami, Touria et al

in International Journal of Oncology (2011), 38

Flavonoids are polyphenolic secondary metabolites from plants that possess a common phenylbenzopyrone structure (C6-C3-C6). Depending upon variations in their heterocyclic C-ring, flavonoids are ... [more ▼]

Flavonoids are polyphenolic secondary metabolites from plants that possess a common phenylbenzopyrone structure (C6-C3-C6). Depending upon variations in their heterocyclic C-ring, flavonoids are categorised into one of the following groups: flavones, flavonols, flavanones, flavanols, anthocyanidins, isoflavones or chalcones. Flavonols include, among others, the molecules quercetin, myricetin and kaempferol. The anticancer activity of flavonols was first attributed to their electron-donating ability, which comes from the presence of phenolic hydroxyl groups. However, an emerging view is that flavonoids, including quercetin, may also exert modulatory actions in cells by acting through the protein kinase and lipid kinase signalling pathways. Data from the current study showed that 2 μM quercetin, a low concentration that represents less than 10% of its IC50 growth inhibitory concentration as calculated from the average of eight distinct cancer cell lines, decreased the activity of 16 kinases by more than 80%, including ABL1, Aurora-A, -B, -C, CLK1, FLT3, JAK3, MET, NEK4, NEK9, PAK3, PIM1, RET, FGF-R2, PDGF-R· and -Rß. Many of these kinases are involved in the control of mitotic processes. Quantitative video microscopy analyses revealed that quercetin displayed strong anti-mitotic activity, leading to cell death. In conclusion, quercetin partly exerts its anticancer activity through the inhibition of the activity of a large set of kinases. Quercetin could be an interesting chemical scaffold from which to generate novel derivatives possessing various types of antikinase activities. [less ▲]

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See detailValdeblore (06) Le Clouté
Pagès, Gaspard ULg

in D.R.A.C., S.R.A. (Ed.) Bilan scientifique de la région Provence-Alpes-Côte d’Azur 2010 (2011)

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See detailOrganisation du territoire de la cité antique de Narbonne : contraintes environnementales et exploitations des ressources
Cavero, Caroline; Sanchez, Corinne; Jézégou, Marie-Pierre et al

in Cavero, Caroline; Sanchez, Corinne; Jézégou, Maries-Pierre (Eds.) et al Fréjus romaine, la ville et son territoire : agglomérations de Narbonnaise, des Alpes-Maritimes et de Cisalpine à travers la recherche archéologique : actes du 8e Colloque historique de Fréjus, 8-10 octobre 2010 (2011)

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See detailSupraorbital transcutaneous neurostimulation has sedative effects in healthy subjects.
Piquet, Maxime; Balestra, Costantino; SAVA, Simona Liliana ULg et al

in BMC Neurology (2011), 11

BACKGROUND: Transcutaneous neurostimulation (TNS) at extracephalic sites is a well known treatment of pain. Thanks to recent technical progress, the Cefaly(R) device now also allows supraorbital TNS ... [more ▼]

BACKGROUND: Transcutaneous neurostimulation (TNS) at extracephalic sites is a well known treatment of pain. Thanks to recent technical progress, the Cefaly(R) device now also allows supraorbital TNS. During observational clinical studies, several patients reported decreased vigilance or even sleepiness during a session of supraorbital TNS. We decided therefore to explore in more detail the potential sedative effect of supraorbital TNS, using standardized psychophysical tests in healthy volunteers. METHODS: We performed a double-blind cross-over sham-controlled study on 30 healthy subjects. They underwent a series of 4 vigilance tests (Psychomotor Vigilance Task, Critical Flicker Fusion Frequency, Fatigue Visual Numeric Scale, d2 test). Each subject was tested under 4 different experimental conditions: without the neurostimulation device, with sham supraorbital TNS, with low frequency supraorbital TNS and with high frequency supraorbital TNS. RESULTS: As judged by the results of three tests (Psychomotor Vigilance Task, Critical Flicker Fusion Frequency, Fatigue Visual Numeric Scale) there was a statistically significant (p < 0.001) decrease in vigilance and attention during high frequency TNS, while there were no changes during the other experimental conditions. Similarly, performance on the d2 test was impaired during high frequency TNS, but this change was not statistically significant. CONCLUSION: Supraorbital high frequency TNS applied with the Cefaly(R) device decreases vigilance in healthy volunteers. Additional studies are needed to determine the duration of this effect, the underlying mechanisms and the possible relation with the stimulation parameters. Meanwhile, this effect opens interesting perspectives for the treatment of hyperarousal states and, possibly, insomnia. [less ▲]

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See detailSleeping Site Selection and Presleep Behavior in Wild Pigtailed Macaques
Albert, Aurélie ULg; Savini, Tommaso ULg; Huynen, Marie-Claude ULg

in American Journal of Primatology (2011), 73

Several factors are likely to control sleeping site selection and presleep behavior in nonhuman primates, including predation risk and location of food resources. We examined the effects of these factors ... [more ▼]

Several factors are likely to control sleeping site selection and presleep behavior in nonhuman primates, including predation risk and location of food resources. We examined the effects of these factors on the sleeping behavior of northern pigtailed macaques (Macaca leonina). While following a troop living in the surroundings of the Visitor Center of Khao Yai National Park (Thailand), we recorded the physical characteristics and location of each sleeping site, tree, the individuals’ place in the tree, posture, and behavior. We collected data for 154 nights between April 2009 and November 2010. The monkeys preferred tall sleeping trees (20.97SD 4.9 m) and high sleeping places (15.87SD 4.3 m), which may be an antipredator strategy. The choice of sleeping trees close to the last (146.77SD 167.9 m) or to the first (150.47SD 113.0 m) feeding tree of the day may save energy and decrease predation risk when monkeys are searching for food. Similarly, the choice of sleeping sites close to human settlements eases the access to human food during periods of fruit scarcity. Finally, the temporal pattern of use of sleeping sites, with a preference for four of the sleeping sites but few reuses during consecutive nights, may be a tradeoff between the need to have several sleeping sites (decreasing detection by predators and travel costs to feeding sites), and the need to sleep in well-known sites (guaranteeing a faster escape in case of predator attack). [less ▲]

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See detailUnderstanding Crystallization of Anatase into Binary SiO2/TiO2 Sol-Gel Optical Thin Films: An in Situ Thermal Ellipsometry Analysis
Louis, B.; Krins, Natacha ULg; Faustini, M. et al

in Journal of Physical Chemistry C: Nanomaterials, Interfaces, and Hard Matter (2011), 115

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See detailContinuous-flow production of alkyl nitrites
Monbaliu, Jean-Christophe ULg; Jorda, Jeremy; Chevalier, Bérengère et al

in Chimica Oggi = Chemistry Today (2011), 29

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See detailConceptions of Social Enterprise and Social Entrepreneurship: Where is the Australian Debate Located??
Nyssens, Marthe; Defourny, Jacques ULg

in Centre for Social Impact (Ed.) Intersecting Transformation of the Business and Third Sector (2011)

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See detailToothed whales in the northwestern Mediterranean: Insight into their feeding ecology using chemical tracers
Praca, Emilie; Laran, Sophie; Lepoint, Gilles ULg et al

in Marine Pollution Bulletin (2011), 62(5), 1058-1065

Risso’s dolphins, pilot whales and sperm whales rarely strand in the northwestern Mediterranean. Thus, their feeding ecology, through the analysis of stomach contents, is poorly known. The aim of this ... [more ▼]

Risso’s dolphins, pilot whales and sperm whales rarely strand in the northwestern Mediterranean. Thus, their feeding ecology, through the analysis of stomach contents, is poorly known. The aim of this study was to gain further insight into the segregation/superposition of the diet and habitat of Risso’s dolphins, pilot whales and sperm whales using chemical tracers, namely, stable isotopes (d13C, d15N) and orga- nochlorines. Significantly different d15N values were obtained in Risso’s dolphins (11.7 ± 0.7‰), sperm whales (10.8 ± 0.3‰) and pilot whales (9.8 ± 0.3‰), revealing different trophic levels. These differences are presumably due to various proportions of Histioteuthidae cephalopods in each toothed whale’s diet. Similar d13C contents between species indicated long-term habitat superposition or corroborated impor- tant seasonal migrations. Lower congener 180 concentrations (8.20 vs. 21.73 lg.g􏰀1 lw) and higher tDDT/ tPCB ratios (0.93 vs. 0.42) were observed in sperm whales compared with Risso’s dolphins and may indi- cate wider migrations for the former. Therefore, competition between these species seems to depend on different trophic levels and migration patterns. [less ▲]

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See detailApport au patrimoine commun et avance sur part de communauté: deux modalités originales. Note sous Liège, 7 septembre 2010
Rousseau, Laura ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2011)

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See detailVariations sur un homme de valeur(s)
Denis, Benoît ULg

in Sindaco, Sarah (Ed.) Jean-Marie Klinkenberg : un homme d'(inter)action (2011)

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See detailVariable Neighborhood Search applied to the Vehicle Routing Problem
François, Véronique ULg

Learning material (2011)

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See detailEffect of the activating agent on physico-chemical and electrical properties of activated carbon cloths developed from a novel cellulosic precursor
Ramos, ME; Bonelli, PR; Blacher, Silvia ULg et al

in Colloids and Surfaces A : Physicochemical and Engineering Aspects (2011), 378(1-3), 87-93

Different chemical reagents (phosphoric acid, boric acid, ammonium citrate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate and trisodium phosphate) were employed ... [more ▼]

Different chemical reagents (phosphoric acid, boric acid, ammonium citrate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate and trisodium phosphate) were employed to develop activated carbon cloths (ACC) by chemical activation of a lyocell precursor, in an attempt to explore their effect on main physico-chemical characteristics and electrical behaviour of the resulting ACC. The activating agent markedly influenced yield, elemental composition, and textural properties of the ACC. The ACC obtained with phosphoric and boric acids were essentially microporous, whereas those developed with the other reagents presented mesoporosity development. Phosphoric acid-derived samples showed the highest specific surface area (976 m2/g). The results also highlight the relevance of correcting the external surface adsorption in order to obtain reliable estimates of micropore volume. All the ACC were electrically conductive, their resistivity being also strongly dependent on the nature of the activating agent. The electrical resistivity of the ACC obtained with all the phosphorous compounds was successfully correlated with their C/H ratio and micropore volume [less ▲]

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See detailRaconter le paysage de la recherche
Mougenot, Catherine ULg

Book published by QUAE (2011)

C’est à un voyage à l’intérieur de la recherche que nous convie Catherine Mougenot, hors des sentiers battus des évaluations, des acquis et des résultats chiffrés. L’aventure commence à l’occasion du ... [more ▼]

C’est à un voyage à l’intérieur de la recherche que nous convie Catherine Mougenot, hors des sentiers battus des évaluations, des acquis et des résultats chiffrés. L’aventure commence à l’occasion du programme de recherche «Action publique, agriculture et biodiversité» rassemblant une communauté très large de chercheurs de terrain : écologues, agronomes, sociologues, géographes, économistes, politiciens, anthropologues, juristes, vétérinaires, toxicologues, qui ont tous accepté la confrontation des disciplines et ce qu’elle implique d’atermoiements, de négociations, de renoncements. Le programme n’est que prétexte à une démarche réflexive dans laquelle l’auteur entraîne les acteurs de la recherche. L’ouvrage prend l’allure de récits où la dimension sensible devient essentielle, ce qui ne veut pas dire que leur travail n’est pas scientifique, mais témoigne de la présence déterminante de cette dimension, au même titre que la passion qui vibre à travers leurs paroles. L’ouvrage devient alors l’histoire des liens de cette communauté, une vision du vécu des chercheurs en regard de quelques grandes questions : la biodiversité, le terrain, l’interdisciplinarité, l’action. Tout au long de cette collecte de récits, Catherine Mougenot s’est efforcée en intervenant le moins possible de ne pas trahir les acteurs. Son écriture à chaud colle à l’expérience, jusqu’au moment où, du travail de montage de ces « histoires », l’auteur tire une analyse très pointue des propriétés du récit. Destiné à la communauté scientifique, cet ouvrage s’adresse également à tous ceux qui vivent la passion de la recherche comme une mise en intrigue. [less ▲]

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See detailL’allo-immunisation fœto-maternelle ABO peut être sévère
SENTERRE, Thibault ULg; Mignon, J.-M.; Rigo, Jacques ULg

in Archives de Pédiatrie (2011), 18

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See detailYoung pigeon disease syndrome
Duchatel, Jean-Pierre ULg; Szeleszczuk, P.

in Medycyna Weterynaryjna (2011), 67(5), 291-294

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