References of "2011"
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See detailCHIC cells: a novel ALK+ cell line derived from a relapsed anaplastic large cell lymphoma
Thielen, Caroline ULg; Bisig, Bettina ULg; Gofflot, Stéphanie ULg et al

in British Journal of Haematology (2011), 152

Since the initial description of anaplastic large cell lymphoma (ALCL) as a proliferation of large CD30+ lymphoid cells, the morphological spectrum of ALCL positive for anaplastic lymphoma kinase (ALCL ... [more ▼]

Since the initial description of anaplastic large cell lymphoma (ALCL) as a proliferation of large CD30+ lymphoid cells, the morphological spectrum of ALCL positive for anaplastic lymphoma kinase (ALCL, ALK+) has expanded, and beyond the common pattern most frequently encountered, several variants have been identified, including the lymphohistiocytic and the small cell patterns (Swerdlow et al, 2008). Only ten ALK+ ALCL cell lines are currently available, and most were derived from tumours demonstrating the common type morphology (Drexler & MacLeod, 2004). We have established a novel cell line (CHIC) from the cerebrospinal fluid of a 32-year-old man with relapsing/refractory ALK+ ALCL with a t(2;5)(p23;q35) translocation whose initial tumour exhibited lymphohistiocytic features. This cell line is now made available to the scientific community. In addition to multiple in vitro applications, the tumourigenic capacity of these cells represents a useful property for in vivo drug testing. [less ▲]

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See detailRegM - Registre de Morbidité
Vanmeerbeek, Marc ULg; Franckh, Marc; Froidcoeur, Xavier ULg

Report (2011)

REGM is a research program about the feasibility of a Belgian morbidity registration system, extracted from existing electronic information systems (EMR) of general practitioners. REGM is part of a larger ... [more ▼]

REGM is a research program about the feasibility of a Belgian morbidity registration system, extracted from existing electronic information systems (EMR) of general practitioners. REGM is part of a larger program which aims to enhance the development of primary health care and improve the quality of care. This part is aimed at the description of three experiments: in France, Switzerland and the Netherlands. [less ▲]

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See detailFlow cytometric detection of myeloperoxidase in horse neutrophils: a novel technique in equine diagnostic research.
Wauters, Jella; Franck, Thierry ULg; Pille, Frederik et al

in Veterinary Immunology and Immunopathology (2011), 144(3-4), 417-22

Myeloperoxidase (MPO) is a protein of interest due to its involvement in equine pathologies. Until now, results in equine diagnostic research were achieved through extracellular MPO detection. However ... [more ▼]

Myeloperoxidase (MPO) is a protein of interest due to its involvement in equine pathologies. Until now, results in equine diagnostic research were achieved through extracellular MPO detection. However, studying the cellular MPO content in neutrophils has revealed important insights in human diseases. This study aimed to develop a technique for the specific detection of MPO on the single cell level defining a flow cytometric protocol for the detection of both equine surface-bound and cellular MPO. Both indirect and direct labeling techniques are described which include the comparison of two secondary antibodies and two linking-fluorochromes, respectively. [less ▲]

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See detailLe centre, les planètes et la noirceur : Controverses cosmiques et terrestres
Nazé, Yaël ULg

Article for general public (2011)

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See detailYBa2Cu3O7−x dispersion in iodine acetone for electrophoretic deposition: Surface charging mechanism in a halogenated organic media
Dusoulier, Laurent; Cloots, Rudi ULg; Vertruyen, Bénédicte ULg et al

in Journal of the European Ceramic Society (2011), 31

Electrophoretic deposition (EPD) performance strongly depends on the particles surface chemistry and the ability to manipulate surface–liquid interfaces. In this study an extensive investigation of YBCO ... [more ▼]

Electrophoretic deposition (EPD) performance strongly depends on the particles surface chemistry and the ability to manipulate surface–liquid interfaces. In this study an extensive investigation of YBCO suspension in dry acetone, acetone–water mixtures and acetone–iodine is reported. Chemical instability of YBCO particles determines their colloidal behaviour. Charging mechanism of particles has therefore had to be deeply investigated for complete dispersion understanding. In order to determine the conditions of the YBCO suspension stability, measurements of pH, conductivity, zeta-potential, settling tests, modelling of the particle networks and electrophoretic deposition were done. The influence of the water and iodine concentration, and their role as stabilizers was evaluated. Based on experimental results, pair particle potentials were calculated and then different charging mechanisms of YBCO surfaces in acetone were proposed. [less ▲]

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See detailField trip 1: Givetian and Frasnian of Southern Belgium
Boulvain, Frédéric ULg; Coen-Aubert, Marie; Da Silva, Anne-Christine ULg et al

in Kölner Forum für Geologie und Paläontologie (2011), 20

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See detailScreening for colorectal cancer in asymptomatic average risk patients: role of imaging.
Hock, D.; Ouhadi, R.; Materne, R. et al

in Acta Gastro-Enterologica Belgica (2011), 74(1), 70-6

Early detection of colorectal cancer or advanced adenomas is a public health priority in many industrialized countries. There are various methods of screening average risk individuals for colorectal ... [more ▼]

Early detection of colorectal cancer or advanced adenomas is a public health priority in many industrialized countries. There are various methods of screening average risk individuals for colorectal cancer, and their effectiveness may depend on subjective parameters like local expertise and patient's preferences. This paper reviews these tests with special emphasis regarding imaging techniques that aim to provide less-invasive alternatives to optical colonoscopy (OC) which is the standard of reference. Both Double-Contrast Barium Enema (DCBE) and Virtual Colonoscopy (VC) have >90% sensitivity compared to OC in the detection of clinically relevant colonic lesions. Nevertheless, VC may have an edge over DCBE for technical and reproductivity reasons, as well as greater learning opportunities. Imaging techniques criticisms regarding diminutive and flat lesions, cost, radiation exposure and effects on gastroenterological practice are addressed. [less ▲]

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See detailNonlinear Normal Modes: A Finite Element Approach
Renson, Ludovic ULg; Kerschen, Gaëtan ULg

Conference (2011)

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See detailGait feature extraction in Parkinson's disease using low-cost accelerometers
Stamatakis, Julien; Cremers, Julien ULg; Maquet, Didier ULg et al

Poster (2011)

The clinical hallmarks of Parkinson’s disease (PD) are movement poverty and slowness (i.e. bradykinesia), muscle rigidity, limb tremor or gait disturbances. Parkinson’s gait include slowness, shuffling ... [more ▼]

The clinical hallmarks of Parkinson’s disease (PD) are movement poverty and slowness (i.e. bradykinesia), muscle rigidity, limb tremor or gait disturbances. Parkinson’s gait include slowness, shuffling, short steps, freezing of gait (FoG) and/or asymmetries in gait. There are currently no validated clinical instruments or device that allow a full characterization of gait disturbances in PD. As a step towards this goal, a four accelerometer-based system is proposed to increase the number of parameters that can be extracted to characterize parkinsonian gait disturbances such as FoG or gait asymmetries. After developing the hardware, an algorithm has been developed, that automatically epoched the signals on a stride-by-stride basis and quantified, among others, the gait velocity, the stride time,the stance and swing phases, the single and double support phases or the maximum acceleration at toe-off, as validated by visual inspection of video recordings during the task. The results obtained in a PD patient and an healthy volunteer are presented. The FoG detection will be improved using time-frequency analysis and the system is about to be validated with a state-of-the-art 3D movement analysis system. [less ▲]

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See detailExperimental validation of opto-thermo-elastic modeling in OOFELIE Multiphysics
Mazzoli, Alexandra ULg; Saint-Georges, Philippe; Orban, Anne ULg et al

in SPIE, Optical Systems Design (Marseille 5-8 septembre 2011) (2011)

The objective of this work is to demonstrate the correlation between a simple laboratory test bench case and the predictions of the Oofelie MultiPhysics software in order to deduce modelling guidelines ... [more ▼]

The objective of this work is to demonstrate the correlation between a simple laboratory test bench case and the predictions of the Oofelie MultiPhysics software in order to deduce modelling guidelines and improvements. For that purpose two optical systems have been analysed. The first one is a spherical lens fixed in an aluminium barrel, which is the simplest structure found in an optomechanical system. In this study, material characteristics are assumed to be well known: BK7 and aluminium have been retained. Temperature variations between 0 and +60°C from ambient have been applied to the samples. The second system is a YAG laser bar heated by means of a dedicated oven. For the two test benches thermo-elastic distortions have been measured using a Fizeau interferometer. This sensor measures wavefront error in the range of 20 nm to 1 μm without physical contact with the optomechanical system. For the YAG bar birefringence and polarization measurements have also been performed using a polarimetric bench. The tests results have been compared to the predictions obtained by Oofelie MultiPhysics which is a multiphysics toolkit treating coupled problems of optics, mechanics, thermal physics, electricity, electromagnetism, acoustics and hydrodynamics. From this comparison modelling guidelines have been issued with the aim of improving the accuracy of computed thermo-elastic distortions and their impact on the optical performances. [less ▲]

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See detailDeterminants of high, median and low rates of caesarean deliveries in Belgium
Absil, Gaëtan ULg; Van Parys, A. S.; Bednarek, Stéphanie et al

Report (2011)

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See detailComment arriver à la prothèse pénienne
Andrianne, Robert ULg

Scientific conference (2011)

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See detailSynthesis by sol-gel process of visible light sensitive-TiO2 for the degradation of pollutants and microorganisms
Tasseroul, Ludivine ULg; Lambert, Stéphanie ULg; Páez Martínez, Carlos ULg et al

Poster (2011)

Since the discovery of photocatalytic decomposition of water on TiO2 electrodes by Fujishima and Honda [1], heterogenous photocatalysis has been widely studied for environmental applications ... [more ▼]

Since the discovery of photocatalytic decomposition of water on TiO2 electrodes by Fujishima and Honda [1], heterogenous photocatalysis has been widely studied for environmental applications. Photocatalytic processes are new technologies for waste water treatment because new compounds (alkanes, pesticides, dyes, etc.) in effluents are not readily degraded by the conventional treatments [2]. Oxidative processes can completely destroy organic pollutants [3] or microorganisms (bacteria, viruses, fungi, etc.) [4,5]. At this moment, the commercial Degussa P25 is the mostly used photocatalyst. Nevertheless, it requires UV light to be activated, that is why scientists try to activate TiO2 under visible light. The aim of this study is to synthesize photocatalysts activated by visible light and to evaluate their activity for the degradation of pollutants and microorganisms. The sol-gel process allows the direct introduction of visible light sensitive species like porphyrins inside the TiO2 matrix during the synthesis [6]. Two tetracarboxyphenyl porphyrins are synthesized for the sensitization of TiO2 to visible light : the metal free tetracarboxyphenyl porphyrin and the nickel tetracarboxyphenyl porphyrin. These porphyrins are characterized by 1H NMR, FT-IR and UV/Vis spectroscopies. They are introduced during the sol-gel synthesis of TiO2 matrix. Diffuse reflectance and FT-IR spectroscopies are used to ensure that porphyrins are incorporated inside the matrix of TiO2. Indeed, characteristic porphyrins peaks appear on spectra. The cristallinity and specific surfaces of catalysts are also determined by XRD and nitrogen adsorption-desorption measurements respectively. The depolluting efficiency of photocatalysts is evaluated for the degradation in water of p-nitrophenol, which is listed as one of the 114 organic pollutants by the Environmental Protection Agency in the US. After 6 h under visible light, 40 % of p-nitrophenol are degraded with some catalysts. The activity is influenced by i) the presence of porphyrins : the photoactivity increases with the amount of porphyrins ; ii) the nature of porphyrins : nickel porphyrins are more active than free metal porphyrins ; and iii) the crystallinity of catalysts : amorphous catalysts are less active than crystallized samples. The photocatalysts with the highest degradation rating of dyes will be selected for the degradation in water of Escherichia coli and Lactobacillus acidophilus. [1] A. Fujishima, K. Honda, Nature 238, 37-38 (1972) [2] P. Gogate, A. Pandit, Advances in Environmental Research 8, 501-551 (2004). [3] D. Chen, A. Ray, Water Research 32, 3223-3234 (1998) [4] R. Watts, S. Kong, M. Orr, G. Miller, B. Henry, Water Research 29, 95-100 (1995). [5] J. Hong, M. Otaki, Journal of Bioscience and Bioengineering 101, 185-189 (2006). [6] C. Wang, J. Li, G. Mele, G.M. Yang, F.-X. Zhang, L. Palmisano, G. Vasapollo, Applied catalysis 78, 218-226 (2007). [less ▲]

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See detailDialectologie, géographie linguistique et étymologie-histoire des mots. Réflexions à partir de l'expérience wallonne
Boutier, Marie-Guy ULg

in Overbeck, Anja; Schweickard, Wolfgang; Völker, Harald (Eds.) Lexicon, Varietät, Philologie. Romansistischen Studien Gunter Holtus zum 65. Geburtstag (2011)

«Il n'y a pas de différence entre les approches comparative et historique selon les plans auxquels opère la démarche: les dialectes ou les langues. […] Les deux plans doivent nécessairement entrer en ... [more ▼]

«Il n'y a pas de différence entre les approches comparative et historique selon les plans auxquels opère la démarche: les dialectes ou les langues. […] Les deux plans doivent nécessairement entrer en dialogue fécond; il y a appel de part et d'autre, au nom de l'intégration des méthodes et des acquis, la synthèse ne pouvant s'effectuer qu'au sein d'une linguistique unique visant un objet unique, la langue.» (Conclusions, p. 360) [less ▲]

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See detailDO PLACEBO BASED VALIDATION STANDARDS MIMIC REAL BATCH PRODUCTS BEHAVIOUR? CASE STUDIES
Bouabidi, A.; Talbi, M.; Bouklouze, A. et al

in Journal of Pharmaceutical & Biomedical Analysis (2011), 55

Analytical methods validation is a mandatory step to evaluate the ability of developed methods to provide accurate results for their routine application. Validation usually involves validation standards ... [more ▼]

Analytical methods validation is a mandatory step to evaluate the ability of developed methods to provide accurate results for their routine application. Validation usually involves validation standards or quality control samples that are prepared in placebo or reconstituted matrix made of a mixture of all the ingredients composing the drug product except the active substance or the analyte under investigation. However, one of the main concerns that can be made with this approach is that it may lack an important source of variability that come from the manufacturing process. The question that remains at the end of the validation step is about the transferability of the quantitative performance from validation standards to real authentic drug product samples. In this work, this topic is investigated through three case studies. Three analytical methods were validated using the commonly spiked placebo validation standards at several concentration levels as well as using samples coming from authentic batch samples (tablets and syrups). The results showed that, depending on the type of response function used as calibration curve, there were various degrees of differences in the results accuracy obtained with the two types of samples. Nonetheless the use of spiked placebo validation standards was showed to mimic relatively well the quantitative behaviour of the analytical methods with authentic batch samples. Adding these authentic batch samples into the validation design may help the analyst to select and confirm the most fit for purpose calibration curve and thus increase the accuracy and reliability of the results generated by the method in routine application. [less ▲]

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See detailEvolution de la pauvreté au Vietnam : quelques réflexions
Mai, Lan Phuong ULg; Lebailly, Philippe ULg; Nguyen Mau, Dung

Conference (2011)

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See detailFaut-il interdire le Bisphenol A dans les récipients destinés à contenir des aliments ?
Scippo, Marie-Louise ULg

in Culture, le magazine culturel en ligne de l'Université de Liège - DOSSIER/ Controverses scientifiques - http://culture.ulg.ac.be/jcms/prod_494506/dossier/-controverses-scientifiques?section=cdu_5047 (2011)

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See detailL'imperatrice. Le Molte Vite di Indira Gandhi
Maiorano, Diego ULg

in Storia della Storiografia (2011), 58

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See detailOptimal design of multi-subject blocked fMRI experiments.
Maus, Bärbel ULg; van Breukelen, Gerard J P; Goebel, Rainer et al

in NeuroImage (2011), 56(3), 1338-1352

The design of a multi-subject fMRI experiment needs specification of the number of subjects and scanning time per subject. For example, for a blocked design with conditions A or B, fixed block length and ... [more ▼]

The design of a multi-subject fMRI experiment needs specification of the number of subjects and scanning time per subject. For example, for a blocked design with conditions A or B, fixed block length and block order ABN, where N denotes a null block, the optimal number of cycles of ABN and the optimal number of subjects have to be determined. This paper presents a method to determine the optimal number of subjects and optimal number of cycles for a blocked design based on the A-optimality criterion and a linear cost function by which the number of cycles and the number of subjects are restricted. Estimation of individual stimulus effects and estimation of contrasts between stimulus effects are both considered. The mixed-effects model is applied and analytical results for the A-optimal number of subjects and A-optimal number of cycles are obtained under the assumption of uncorrelated errors. For correlated errors with a first-order autoregressive (AR1) error structure, numerical results are presented. Our results show how the optimal number of cycles and subjects depend on the within- to between-subject variance ratio. Our method is a new approach to determine the optimal scanning time and optimal number of subjects for a multi-subject fMRI experiment. In contrast to previous results based on power analyses, the optimal number of cycles and subjects can be described analytically and costs are considered. [less ▲]

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