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See detailLa preuve scientifique évitée: Inventaire de quelques techniques judiciaires
Sibony, Anne-Lise ULg

in Thruilhé-Marengo, Eve (Ed.) Preuve scientifique, preuve juridique (2011)

Cet article envisage différentes techniques par lesquelles une juridiction peut éviter d'avoir à examiner des preuves scientifiques là même où elles pourraient être pertinentes.

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See detailControl of hydrogen photoproduction by the proton gradient generated by cyclic electron flow in Chlamydomonas reinhardtii.
Tolleter, Dimitri; Ghysels, Bart ULg; Alric, Jean et al

in Plant Cell (2011), 23(7), 2619-30

Hydrogen photoproduction by eukaryotic microalgae results from a connection between the photosynthetic electron transport chain and a plastidial hydrogenase. Algal H(2) production is a transitory ... [more ▼]

Hydrogen photoproduction by eukaryotic microalgae results from a connection between the photosynthetic electron transport chain and a plastidial hydrogenase. Algal H(2) production is a transitory phenomenon under most natural conditions, often viewed as a safety valve protecting the photosynthetic electron transport chain from overreduction. From the colony screening of an insertion mutant library of the unicellular green alga Chlamydomonas reinhardtii based on the analysis of dark-light chlorophyll fluorescence transients, we isolated a mutant impaired in cyclic electron flow around photosystem I (CEF) due to a defect in the Proton Gradient Regulation Like1 (PGRL1) protein. Under aerobiosis, nonphotochemical quenching of fluorescence (NPQ) is strongly decreased in pgrl1. Under anaerobiosis, H(2) photoproduction is strongly enhanced in the pgrl1 mutant, both during short-term and long-term measurements (in conditions of sulfur deprivation). Based on the light dependence of NPQ and hydrogen production, as well as on the enhanced hydrogen production observed in the wild-type strain in the presence of the uncoupling agent carbonyl cyanide p-trifluoromethoxyphenylhydrazone, we conclude that the proton gradient generated by CEF provokes a strong inhibition of electron supply to the hydrogenase in the wild-type strain, which is released in the pgrl1 mutant. Regulation of the trans-thylakoidal proton gradient by monitoring pgrl1 expression opens new perspectives toward reprogramming the cellular metabolism of microalgae for enhanced H(2) production. [less ▲]

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See detailValdeblore (06) Le Clouté
Pagès, Gaspard ULg

in D.R.A.C., S.R.A. (Ed.) Bilan scientifique de la région Provence-Alpes-Côte d’Azur 2010 (2011)

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See detailOrganisation du territoire de la cité antique de Narbonne : contraintes environnementales et exploitations des ressources
Cavero, Caroline; Sanchez, Corinne; Jézégou, Marie-Pierre et al

in Cavero, Caroline; Sanchez, Corinne; Jézégou, Maries-Pierre (Eds.) et al Fréjus romaine, la ville et son territoire : agglomérations de Narbonnaise, des Alpes-Maritimes et de Cisalpine à travers la recherche archéologique : actes du 8e Colloque historique de Fréjus, 8-10 octobre 2010 (2011)

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See detailSupraorbital transcutaneous neurostimulation has sedative effects in healthy subjects.
Piquet, Maxime; Balestra, Costantino; SAVA, Simona Liliana ULg et al

in BMC Neurology (2011), 11

BACKGROUND: Transcutaneous neurostimulation (TNS) at extracephalic sites is a well known treatment of pain. Thanks to recent technical progress, the Cefaly(R) device now also allows supraorbital TNS ... [more ▼]

BACKGROUND: Transcutaneous neurostimulation (TNS) at extracephalic sites is a well known treatment of pain. Thanks to recent technical progress, the Cefaly(R) device now also allows supraorbital TNS. During observational clinical studies, several patients reported decreased vigilance or even sleepiness during a session of supraorbital TNS. We decided therefore to explore in more detail the potential sedative effect of supraorbital TNS, using standardized psychophysical tests in healthy volunteers. METHODS: We performed a double-blind cross-over sham-controlled study on 30 healthy subjects. They underwent a series of 4 vigilance tests (Psychomotor Vigilance Task, Critical Flicker Fusion Frequency, Fatigue Visual Numeric Scale, d2 test). Each subject was tested under 4 different experimental conditions: without the neurostimulation device, with sham supraorbital TNS, with low frequency supraorbital TNS and with high frequency supraorbital TNS. RESULTS: As judged by the results of three tests (Psychomotor Vigilance Task, Critical Flicker Fusion Frequency, Fatigue Visual Numeric Scale) there was a statistically significant (p < 0.001) decrease in vigilance and attention during high frequency TNS, while there were no changes during the other experimental conditions. Similarly, performance on the d2 test was impaired during high frequency TNS, but this change was not statistically significant. CONCLUSION: Supraorbital high frequency TNS applied with the Cefaly(R) device decreases vigilance in healthy volunteers. Additional studies are needed to determine the duration of this effect, the underlying mechanisms and the possible relation with the stimulation parameters. Meanwhile, this effect opens interesting perspectives for the treatment of hyperarousal states and, possibly, insomnia. [less ▲]

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See detailAnalysis of insurance claims after vascular surgery: a tool for quality improvement?
Kolh, Philippe ULg

in European Journal of Vascular and Endovascular Surgery (2011), 42(4), 506-7

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See detailSubject-specific cardiovascular system model-based identification and diagnosis of septic shock with a minimally invasive data set: animal experiments and proof of concept.
Chase, J Geoffrey; Lambermont, Bernard ULg; Starfinger, Christina et al

in Physiological Measurement (2011), 32(1), 65-82

A cardiovascular system (CVS) model and parameter identification method have previously been validated for identifying different cardiac and circulatory dysfunctions in simulation and using porcine models ... [more ▼]

A cardiovascular system (CVS) model and parameter identification method have previously been validated for identifying different cardiac and circulatory dysfunctions in simulation and using porcine models of pulmonary embolism, hypovolemia with PEEP titrations and induced endotoxic shock. However, these studies required both left and right heart catheters to collect the data required for subject-specific monitoring and diagnosis-a maximally invasive data set in a critical care setting although it does occur in practice. Hence, use of this model-based diagnostic would require significant additional invasive sensors for some subjects, which is unacceptable in some, if not all, cases. The main goal of this study is to prove the concept of using only measurements from one side of the heart (right) in a 'minimal' data set to identify an effective patient-specific model that can capture key clinical trends in endotoxic shock. This research extends existing methods to a reduced and minimal data set requiring only a single catheter and reducing the risk of infection and other complications-a very common, typical situation in critical care patients, particularly after cardiac surgery. The extended methods and assumptions that found it are developed and presented in a case study for the patient-specific parameter identification of pig-specific parameters in an animal model of induced endotoxic shock. This case study is used to define the impact of this minimal data set on the quality and accuracy of the model application for monitoring, detecting and diagnosing septic shock. Six anesthetized healthy pigs weighing 20-30 kg received a 0.5 mg kg(-1) endotoxin infusion over a period of 30 min from T0 to T30. For this research, only right heart measurements were obtained. Errors for the identified model are within 8% when the model is identified from data, re-simulated and then compared to the experimentally measured data, including measurements not used in the identification process for validation. Importantly, all identified parameter trends match physiologically and clinically and experimentally expected changes, indicating that no diagnostic power is lost. This work represents a further with human subjects validation for this model-based approach to cardiovascular diagnosis and therapy guidance in monitoring endotoxic disease states. The results and methods obtained can be readily extended from this case study to the other animal model results presented previously. Overall, these results provide further support for prospective, proof of concept clinical testing with humans. [less ▲]

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See detailContinuous-flow production of alkyl nitrites
Monbaliu, Jean-Christophe ULg; Jorda, Jeremy; Chevalier, Bérengère et al

in Chimica Oggi = Chemistry Today (2011), 29

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See detailThree-dimensional void space structure of activated carbon packed beds
Almazan Almazan, Maria Del Carmen; Léonard, Angélique ULg; Job, Nathalie ULg et al

in Journal of Porous Materials (2011), 18

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See detailTomographic measurement of liquid hold up and effective interfacial area distributions in a column packed with high performance structured packings
Aferka, Saïd ULg; Viva, Aurora; Brunazzi, Elisabetta et al

in Chemical Engineering Science (2011), 66

In this paper, we report on the use of a high energy and high resolution X-ray tomograph to visualize and quantify the distribution of liquid hold up and of gas-liquid interfacial area in a 0.1m diameter ... [more ▼]

In this paper, we report on the use of a high energy and high resolution X-ray tomograph to visualize and quantify the distribution of liquid hold up and of gas-liquid interfacial area in a 0.1m diameter column filled with MellapakPlus 752.Y packing elements. A standard air-water system at room temperature and atmospheric pressure was used. Tomographic measurements have been carried out in a large number of packing cross sections situated at different heights between the top and the bottom of the packed column, giving access to the evolution of axial profiles of liquid hold up and of gas-liquid interfacial area as a function of the operating conditions. Gas-liquid interfacial area values were also measured by a chemical method (CO2 absorption from air into a caustic solution). For the first time, a whole set of gas-liquid interfacial area values evaluated from tomographic images are interestingly compared with values measured by a chemical method. A comparison is also presented with literature models. [less ▲]

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See detailSquatting test: a dynamic postural manoeuvre to study baroreflex sensitivity.
SCHEEN, André ULg; PHILIPS, Jean-Christophe ULg

in Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2011)

INTRODUCTION: Squatting is an active posture test that can be used to assess baroreflex sensitivity. Indeed, the shift from squatting to standing imposes a major orthostatic stress leading to rapid and ... [more ▼]

INTRODUCTION: Squatting is an active posture test that can be used to assess baroreflex sensitivity. Indeed, the shift from squatting to standing imposes a major orthostatic stress leading to rapid and large changes in arterial blood pressure (BP) and heart rate (HR) allowing precise baroreflex assessment. MATERIAL AND METHODS: BP and HR can be continuously and non-invasively monitored with a Finapres device. RESULTS: The standing to squatting transition is accompanied by rises in BP, pulse pressure and cardiac output, mainly due to increased venous return, and by a secondary reduction in HR. Conversely, the squatting to standing transition is associated with an immediate drop in BP and both reflex tachycardia and vasoconstriction. This mirror changes in BP and HR, mimicking those observed with the classical pharmacological approach using vasopressor/vasodilating agents, allows the calculation of the so-called baroreflex gain. DISCUSSION: The present review describes the haemodynamic changes occurring in normal subjects during the shifts from standing to squatting and from squatting to standing and discusses the underlying cardiovascular and autonomic mechanisms. CONCLUSION: This careful analysis in healthy individuals should help in the understanding of disturbances that may be observed in patients with autonomic dysfunction, such as in diabetic patients with cardiovascular autonomic neuropathy. [less ▲]

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See detailEffect of the activating agent on physico-chemical and electrical properties of activated carbon cloths developed from a novel cellulosic precursor
Ramos, ME; Bonelli, PR; Blacher, Silvia ULg et al

in Colloids and Surfaces A : Physicochemical and Engineering Aspects (2011), 378(1-3), 87-93

Different chemical reagents (phosphoric acid, boric acid, ammonium citrate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate and trisodium phosphate) were employed ... [more ▼]

Different chemical reagents (phosphoric acid, boric acid, ammonium citrate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate and trisodium phosphate) were employed to develop activated carbon cloths (ACC) by chemical activation of a lyocell precursor, in an attempt to explore their effect on main physico-chemical characteristics and electrical behaviour of the resulting ACC. The activating agent markedly influenced yield, elemental composition, and textural properties of the ACC. The ACC obtained with phosphoric and boric acids were essentially microporous, whereas those developed with the other reagents presented mesoporosity development. Phosphoric acid-derived samples showed the highest specific surface area (976 m2/g). The results also highlight the relevance of correcting the external surface adsorption in order to obtain reliable estimates of micropore volume. All the ACC were electrically conductive, their resistivity being also strongly dependent on the nature of the activating agent. The electrical resistivity of the ACC obtained with all the phosphorous compounds was successfully correlated with their C/H ratio and micropore volume [less ▲]

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See detailUne précision constitutionnelle du domaine d'application de la revalorisation des récompenses? Note sous C.const. 16 septembre 2010
Laruelle, Julie ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2011)

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See detailL’allo-immunisation fœto-maternelle ABO peut être sévère
SENTERRE, Thibault ULg; Mignon, J.-M.; Rigo, Jacques ULg

in Archives de Pédiatrie (2011), 18

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See detailThe Use of Phages and Aptamers as Alternatives to Antibodies in Medical and Food Diagnostics.
Mehta, Jaytry; Van Dorst, Bieke; Devriese, Lisa et al

in Komorowska, Malgorzata Anna; Olsztynska-Janus, Sylwia (Eds.) Biomedical Engineering, Trends, Research and Technologies (2011)

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See detailARM XIX-la séquence SI.LA2 2 = si-la2-min (NP) et quelques relectures de noms propres
Colonna d'Istria, Laurent ULg

in Nouvelles Assyriologiques Brèves et Utilitaires (2011)

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