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See detailChlamydomonas can play a role in the study of a heteroplasmic human mitochondrial mutation
Larosa, Véronique ULg; Coosemans, Nadine ULg; Bonnefoy, Nathalie et al

Scientific conference (2011)

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See detailCdk6-dependent regulation of g(1) length controls adult neurogenesis.
Beukelaers, Pierre; Vandenbosch, Renaud ULg; Caron, Nicolas ULg et al

in Stem Cells (2011), 29(4), 713-24

The presence of neurogenic precursors in the adult mammalian brain is now widely accepted, but the mechanisms coupling their proliferation with the onset of neuronal differentiation remain unknown. Here ... [more ▼]

The presence of neurogenic precursors in the adult mammalian brain is now widely accepted, but the mechanisms coupling their proliferation with the onset of neuronal differentiation remain unknown. Here, we unravel the major contribution of the G(1) regulator cyclin-dependent kinase 6 (Cdk6) to adult neurogenesis. We found that Cdk6 was essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Specifically, Cdk6 deficiency prevents the expansion of neuronally committed precursors by lengthening G(1) phase duration, reducing concomitantly the production of newborn neurons. Altogether, our data support G(1) length as an essential regulator of the switch between proliferation and neuronal differentiation in the adult brain and Cdk6 as one intrinsic key molecular regulator of this process. STEM Cells 2011;29:713-724. [less ▲]

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See detailSentiment d’altérité dans la correspondance de Rousseau en 1762
Biquet, Stéphanie ULg

in Turekova, Andrea (Ed.) Conférence internationale Autre - Autrui - Altérité (2011)

Jean-Jacques Rousseau est né avec la conscience de son altérité : fils d’horloger, citoyen de Genève, il se sent dès son plus jeune âge différent du monde qui l’entoure. Par sa « réforme » au début des ... [more ▼]

Jean-Jacques Rousseau est né avec la conscience de son altérité : fils d’horloger, citoyen de Genève, il se sent dès son plus jeune âge différent du monde qui l’entoure. Par sa « réforme » au début des années 1750, il transformera officiellement cette altérité en faire-valoir. Pourtant, quand résonne le glas de la condamnation de ses œuvres (Émile et le Contrat social) en 1762, l’homme jusque-là différent, se sent étranger, incompris, seul contre tous, comme en témoigne sa correspondance. Cet article se donne pour objectif d’étudier ce sentiment d’altérité et d’étrangeté à travers la correspondance personnelle de Jean-Jacques Rousseau de 1762 à 1765 (soit de la condamnation de l’Émile et du Contrat social jusqu'au départ pour l’Angleterre chez David Hume). [less ▲]

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See detailRelationship between bone mineral density changes and risk of fractures among patients receiving calcium with or without vitamin D supplementation: a meta-regression
Rabenda, Véronique ULg; Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2011), 22

Surrogate measures of fracture risk, such as effects on bone mineral density, may be of great interest to assess the efficacy of available osteoporosis treatments. Our results suggest that bone mineral ... [more ▼]

Surrogate measures of fracture risk, such as effects on bone mineral density, may be of great interest to assess the efficacy of available osteoporosis treatments. Our results suggest that bone mineral density (BMD) changes cannot be used as a surrogate of anti-fracture efficacy, among patients receiving calcium, with or without vitamin D. Introduction: The purpose of this study is to examine the association between changes in bone mineral density with reduction in the risk of fractures in patients receiving calcium with or without vitamin D. Methods: We selected all randomized placebo-controlled clinical trials of calcium with or without vitamin D supplementation. To be included in this analysis, the studies were required to report both BMD (hip/proximal femur and/or lumbar spine) and the incidence of fractures. Metaregression analyses were used to examine the associations of changes in BMD with reduction in risk of fracture over the duration of each study. The change in BMD was the difference between changes (from baseline) observed in the active treatment group and placebo group. Results: A total of 15 randomized trials (n=47,365) were identified, most of whom (77%) came from the Women’s Health Initiative trial. Results show that larger increases in BMD at the lumbar spine were not associated with greater reduction in fracture risk. Concerning hip BMD changes, we found a statistically significant relationship between hip BMD changes and reduction in risk. However, results were not quite significant after excluding the both largest studies, in which BMD changes were measured in very small subset of patients. These points may have largely biased our results. Conclusions: In conclusion, there was no evidence of a relationship between BMD changes and reduction in risk of fractures among patients receiving calcium with or without vitamin D supplementation. Calcium and/or Vitamin D may reduce fracture rates through a mechanism independent of bone density. [less ▲]

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See detailLe modèle de croissance katangais face à la crise financière mondiale : enjeux en termes d'emploi
Lapeyre, Frédéric; Lebailly, Philippe ULg; Musewa M'Bayo, Laki et al

Book published by Bureau International du Travail (2011)

La crise financière mondiale qui a éclaté en 2008 et les effets désastreux qu’elle a occasionnés sur le secteur minier en RDC (qui avait été placé au centre des politiques de croissance et de lutte contre ... [more ▼]

La crise financière mondiale qui a éclaté en 2008 et les effets désastreux qu’elle a occasionnés sur le secteur minier en RDC (qui avait été placé au centre des politiques de croissance et de lutte contre la pauvreté) posent avec encore plus d’acuité la question de la diversification de la structure économique dans une province comme le Katanga. Au problème de la vulnérabilité d’un tel modèle de croissance s’ajoute le constat qui est fait dans cette étude du manque d’effet d’entrainement de l’activité des grands groupes miniers sur le reste de l’économie locale, en termes de développement des capacités productives et de création d’emplois. [less ▲]

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See detailFinal results of NKTR-102, a topoisomerase I inhibitor-polymer conjugate, in patients (Pts) with pretreated metastatic breast cancer (MBC) demonstrating significant antitumor activity
Garcia, A; Awada, A; Chan, S et al

in Journal of Clinical Oncology (2011), 29(supplement 27),

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See detailUrinary NGAL measurement : Biological variation and ratio to creatinine
Delanaye, Pierre ULg; Rozet, Eric ULg; Krzesinski, Jean-Marie ULg et al

in Clinica Chimica Acta (2011), 412(3-4), 390

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See detailPhysico-chemical and morphological properties of current particulated biomaterials used in alveolar bone augmentations: a review.
LAMBERT, France ULg; Layrolle, Pierre; ROMPEN, Eric ULg et al

in Journal of Osteology and Biomaterials (2011), 2

The efficacy of grafting materials for alveolar bone regeneration procedures has been repeatedly corroborated by clinical and scientific evidence. Although an ever growing number of biomaterials are ... [more ▼]

The efficacy of grafting materials for alveolar bone regeneration procedures has been repeatedly corroborated by clinical and scientific evidence. Although an ever growing number of biomaterials are available on the market, the origins, material characteristics, bioactivity and osteoconductive properties of these products are not always known by clinicians, hence often hampering an adequate product selection. The purpose of this contribution was to provide an overview of five different types of osteoconductive grafting materials frequently used in dentistry (Bio-Oss®, Cerasorb M™, Bone Ceramic®, Natix®, Genos®) and to summarize their physico-chemical and morphological characteristics at the macro- and micro-scale. Furthermore, the influence of these properties on the in vivo behaviour of these biomaterials is discussed. The results of this study are presented as data sheets, which may prove helpful for clinicians in the design of their treatment strategies. [less ▲]

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See detailLe ciel est bleu comme une horloge...
Nazé, Yaël ULg

Article for general public (2011)

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See detailTropfenpopulationsbilanzen zur Auslegung von Extraktionskolonnen
Adinata, Donni; Ayesteran, José M.; Buchbender, Florian et al

in Chemie Ingenieur Technik (2011), 83(7), 952964

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See detailLes Codes La Charte. Droit international conventionnel et Droit administratif
Bourgeois, Marc ULg; Behrendt, Christian ULg; Lewalle, Paul ULg et al

Book published by La Charte (2011)

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See detailcompte rendu de : Giuseppe ARICÒ – Massimo RIVOLTELLA (Ed.), La riflessione sul teatro nella cultura romana
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2011)

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See detailReciprocal interactions between wakefulness and sleep influence global and regional brain activity
Muto, Vincenzo ULg; Mascetti, Laura ULg; Matarazzo, Luca et al

in Current Topics in Medicinal Chemistry (2011), 11(19), 2403-13

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See detailInfluence of zirconia framework thickness on residual stress profile in veneering ceramic: Measurement by hole-drilling.
MAINJOT, Amélie ULg; Schajer, G. S.; Vanheusden, Alain ULg et al

in Dental Materials (2011)

OBJECTIVES: Framework design is reported to influence chipping in zirconia-based restorations, which is an important cause of failure of such restorations. Residual stress profile in the veneering ceramic ... [more ▼]

OBJECTIVES: Framework design is reported to influence chipping in zirconia-based restorations, which is an important cause of failure of such restorations. Residual stress profile in the veneering ceramic after the manufacturing process is an important predictive factor of the mechanical behavior of the material. The objective of this study is to investigate the influence of framework thickness on the stress profile measured in zirconia-based structures. METHODS: The stress profile was measured with the hole-drilling method in bilayered disc samples of 20mm diameter with a 1.5mm thick veneering ceramic layer. Six different framework thicknesses from 0.5mm to 3mm were studied. Two different cooling procedures were also investigated. RESULTS: Compressive stresses were observed in the surface, and tensile stresses in the depth of most of the samples. The slow cooling procedure was found to promote the development of interior tensile stresses, except for the sample with a 3mm thick framework. With the tempering procedure, samples with a 1.5mm thick framework exhibited the most favorable stress profile, while thicker and thinner frameworks exhibited respectively in surface or interior tensile stresses. Significance: The measurements performed highlight the importance of framework thickness, which determine the nature of stresses and can explain clinical failures encountered, especially with thin frameworks. The adequate ratio between veneering ceramic and zirconia is hard to define, restricting the range of indications of zirconia-based restorations until a better understanding of such a delicate veneering process is achieved. [less ▲]

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See detailAn intermediate in the evolution of superfast sonic muscles.
Mok, H.; Parmentier, Eric ULg; Chiu, H. et al

in Frontiers in Zoology (2011), 8

Background Intermediate forms in the evolution of new adaptations such as transitions from water to land and the evolution of flight are often poorly understood. Similarly, the evolution of superfast ... [more ▼]

Background Intermediate forms in the evolution of new adaptations such as transitions from water to land and the evolution of flight are often poorly understood. Similarly, the evolution of superfast sonic muscles in fishes, often considered the fastest muscles in vertebrates, has been a mystery because slow bladder movement does not generate sound. Slow muscles that stretch the swimbladder and then produce sound during recoil have recently been discovered in ophidiiform fishes. Here we describe the disturbance call (produced when fish are held) and sonic mechanism in an unrelated perciform pearl perch (Glaucosomatidae) that represents an intermediate condition in the evolution of super-fast sonic muscles. Results The pearl perch disturbance call is a two-part sound produced by a fast sonic muscle that rapidly stretches the bladder and an antagonistic tendon-smooth muscle combination (part 1) causing the tendon and bladder to snap back (part 2) generating a higher-frequency and greater-amplitude pulse. The smooth muscle is confirmed by electron microscopy and protein analysis. To our knowledge smooth muscle attachment to a tendon is unknown in animals. Conclusion The pearl perch, an advanced perciform teleost unrelated to ophidiiform fishes, uses a slow type mechanism to produce the major portion of the sound pulse during recoil, but the swimbladder is stretched by a fast muscle. Similarities between the two unrelated lineages, suggest independent and convergent evolution of sonic muscles and indicate intermediate forms in the evolution of superfast muscles. [less ▲]

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See detailPhenotypic evaluation of interspecific recombinant inbred lines (RILs) of Phaseolus species for their resistance to aluminum and tolerance to aluminum-toxic acid soil under greenhouse conditions
Butare, Louis; Rao, I. M.; Lepoivre, Philippe ULg et al

in Euphytica : International Journal of Plant Breeding (2011)

Aluminium (Al) toxicity limits common bean productivity in acid soil regions of the tropics. To improve Al resistance of common bean, Al-sensitive Phaseolus vulgaris (SER16) was crossed to Alresistant P ... [more ▼]

Aluminium (Al) toxicity limits common bean productivity in acid soil regions of the tropics. To improve Al resistance of common bean, Al-sensitive Phaseolus vulgaris (SER16) was crossed to Alresistant P. coccineus (G35346-3Q) to create 94 F5:6 recombinant inbred lines (RILs) of the pedigree SER16 9 (SER16 9 G35346-3Q). RILs were characterized for resistance to Al in a hydroponic system with 0 and 20 lM Al in solution, and for shoot and root growth response to Al-toxic infertile acid soil in 75 cm long soil cylinder system using an oxisol of low Al- (12.5%; pH 4.6; fertilized) and high Al-saturation (77%; pH 4.1; unfertilized). G35346-3Q increased its taproot elongation rate by 3.5% between 24 and 48 h under 20 lM Al in solution, while the best RIL, Andean genotype ICA Quimbaya, and sensitive genotype VAX1 expressed reductions of 2.6, 12.5, and 69.5%, respectively. In the acid soil treatment the correlation between leaf area and total root length was highly significant under high Al saturation (r = 0.70***). Genotypes that were Al resistant in the hydroponic system were not necessarily tolerant to Al-toxic acid soil conditions based on shoot and root growth responses. Phenotypic evaluation using both systems allows the identification of genotypes with Al resistance combined with acid soil adaptation. Two genotypes (ALB88 and ALB91) emerged as lines with multiple traits. Results suggest that inheritance of Al resistance and acid soil tolerance in G35346-3Q is complex. Results from this work will be useful for identification of molecular markers for Al resistance in Phaseolus species and to improve acid soil adaptation in common bean. [less ▲]

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See detailTolerability of shortened infliximab infusion times in patients with inflammatory bowel disease: a single center cohort study
Breynaert, C; Ferrante, F; Fidder, H et al

in Acta Gastro-Enterologica Belgica (2011)

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See detailMitotic spindle: focus on the function of huntingtin
Godin, Juliette ULg; Humbert, Sandrine

in International Journal of Biochemistry & Cell Biology (2011), 43(6), 852-856

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See detailIdentification of novel secreted proteases during extracellular proteolysis by dermatophytes at acidic pH
Sriranganadane, D.; Waridel, P.; Salamin, K. et al

in Proteomics (2011), 11(22), 4422-4433

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