References of "2011"
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See detailRecollection and familiarity processes in probable Alzheimer's disease: an fMRI study
Genon, Sarah ULg; Collette, Fabienne ULg; Salmon, Eric ULg et al

in Proceedings of the 5th International Conference on Memory (2011)

Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during ... [more ▼]

Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during performance of a recognition memory task with the process dissociation procedure. Brain regions associated to recollection were evidenced by contrasting activations for inclusion and exclusion conditions whereas brain regions related to familiarity were explored with the mean effect of the two conditions (at P < .05 corrected). Twelve patients had null recollection estimates (AD-), whereas 16 patients did experience some recollection although significantly less than controls (AD+). In AD+ and controls, recollection activated the posterior cingulate cortex (PCC). In contrast, familiarity estimates were equivalent in the 3 groups and were associated with brain activations around the intraparietal sulcus (IPS). Thus, in AD, impaired recollection is related to damage of the PCC whereas preserved familiarity is supported by the IPS. [less ▲]

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See detailCoping with Minority Status: Responses to Exclusion and Inclusion
Martiniello, Marco ULg

in Contemporary Sociology: a Journal of Reviews (2011), 40(2), 158-159

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See detailNotched Specimens Fracture Prediction with an Advanced GTN Model
Fansi Tchonko, Joseph ULg; Ben Bettaieb, Mohamed ULg; Balan, Tudor et al

in Key Engineering Materials [=KEM] (2011), 488-489

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See detailLa tradizione fiorentina della Supplicatione d’Italia al re di Francia. Con una nuova edizione critica
Moreno, Paola ULg

in Filologia e Critica (2011), XXXV(2), 1-33

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See detailTransient Fokker-Planck Equation solved with SPH
Canor, Thomas ULg; Denoël, Vincent ULg

in Proceedings of the 5th International Conference on Advanced Computational Methods in Engineering (2011)

In many engineering matters, systems are submitted to random excitations. Probabilistic theories aim at describing the properties of a system by means of statistical properties such as probability density ... [more ▼]

In many engineering matters, systems are submitted to random excitations. Probabilistic theories aim at describing the properties of a system by means of statistical properties such as probability density function (pdf). For a deterministic system randomly excited, the evolution of its pdf is commonly described with Fokker-Planck-Kolmogorov equation (FPK). The FPK equation is a conservation equation of a hypothetical fluid, which represents physically the transport of probability. To solve this equation, Smoothed Particle Hydrodynamics (SPH) are used: the system is modelled with a conservation equation for the system and a transport equation for each particle. Numerical implementation shows the superiority of this method over many other mesh-based methods: (i) the conservation of total probability in the state space is explicitly written, (ii) no specific boundary conditions must be imposed if an adaptive smoothing length is chosen and if particles are initially regularly spread out, (iii) the positivity of the pdf is ensured. Furthermore, thanks to the moving particles, this method is adapted for a large kind of initial conditions (quasi-deterministic or even discontinuous). The FPK equation can be solved without any a priori knowledge of the stationary distribution; just a precise representation of the initial distribution is required. [less ▲]

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See detailMalignant catarrhal fever induced by Alcelaphine herpesvirus 1 is characterized by an expansion of activated CD3+CD8+CD4- T cells expressing a cytotoxic phenotype in both lymphoid and non-lymphoid tissues.
Dewals, Benjamin G ULg; Vanderplasschen, Alain ULg

in Veterinary research (2011), 42(1), 95

ABSTRACT: Alcelaphine herpesvirus 1 (AlHV-1) is carried by wildebeest asymptomatically. It causes a fatal lymphoproliferative disease named wildebeest-derived malignant catarrhal fever (WD-MCF) when cross ... [more ▼]

ABSTRACT: Alcelaphine herpesvirus 1 (AlHV-1) is carried by wildebeest asymptomatically. It causes a fatal lymphoproliferative disease named wildebeest-derived malignant catarrhal fever (WD-MCF) when cross-species transmitted to a variety of susceptible species of the Artiodactyla order. WD-MCF can be reproduced experimentally in rabbits. In a previous report, we demonstrated that WD-MCF induced by AlHV-1 is associated with a severe proliferation of CD8+ T cells in the lymphoid tissues. Here, we further studied the mononuclear leukocytic populations in both the lymphoid (throughout the infection and at time of euthanasia) and non-lymphoid (at time of euthanasia) organs during WD-MCF induced experimentally in rabbits. To reach that goal, we performed multi-colour flow cytometry stainings. The results obtained demonstrate that the development of WD-MCF correlates in peripheral blood with a severe increase of CD8+ cell percentages; and that CD3+CD8+CD4- T cells were the predominant cell type in both lymphoid and non-lymphoid organs at time of euthanasia. Further characterization of the mononuclear leukocytes isolated from both lymphoid and non-lymphoid tissues revealed that the CD8+ T cells express high levels of the activation markers CD25 and CD44, produce high amount of gamma-interferon (IFN-gamma) and perforin, and showed a reduction of interleukin-2 (IL-2) gene expression. These data demonstrate that the development of WD-MCF is associated with the expansion and infiltration of activated and cytotoxic CD3+CD8+CD4- T cells secreting high amount of IFN-gamma but low IL-2. [less ▲]

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See detailBeyond matching on the mean in developmental disabilities research
Facon, Bruno; Magis, David ULg; Belmont, John M

in Research in Developmental Disabilities (2011), 32

The matching of groups is a traditional way to control for confounding variables in developmental disability research. The equivalency of means across groups is routinely checked for these variables, but ... [more ▼]

The matching of groups is a traditional way to control for confounding variables in developmental disability research. The equivalency of means across groups is routinely checked for these variables, but not the homogeneity of their variances or the shapes of their distributions. In the present paper, it is argued that group matching can go seriously wrong unless it directly confronts the distributional concerns by the use of well-known statistical indices and very simple graphical displays of the distributions. The question of the equivalency of item response profiles is also addressed since two participants or two groups of participants can obtain the same overall score on the matching variable by passing different items. In this case, the matching cannot be considered satisfactory because of poor concordance between the molar (overall score) and molecular (item scores) levels of matching. Angoff's Delta plot method, a statistical approach for detecting differential item functioning across small groups is described. It is promising as a simple way to prove whole test/individual item correspondence and, in addition, a useful tool for making post-hoc statistical analyses at the item level on the dependant variables. [less ▲]

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See detailBrain functional integration decreases during propofol-induced loss of consciousness.
Schrouff, Jessica ULg; Perlbarg, Vincent; Boly, Mélanie ULg et al

in NeuroImage (2011), 57(1), 198-205

Consciousness has been related to the amount of integrated information that the brain is able to generate. In this paper, we tested the hypothesis that the loss of consciousness caused by propofol ... [more ▼]

Consciousness has been related to the amount of integrated information that the brain is able to generate. In this paper, we tested the hypothesis that the loss of consciousness caused by propofol anesthesia is associated with a significant reduction in the capacity of the brain to integrate information. To assess the functional structure of the whole brain, functional integration and partial correlations were computed from fMRI data acquired from 18 healthy volunteers during resting wakefulness and propofol-induced deep sedation. Total integration was significantly reduced from wakefulness to deep sedation in the whole brain as well as within and between its constituent networks (or systems). Integration was systematically reduced within each system (i.e., brain or networks), as well as between networks. However, the ventral attentional network maintained interactions with most other networks during deep sedation. Partial correlations further suggested that functional connectivity was particularly affected between parietal areas and frontal or temporal regions during deep sedation. Our findings suggest that the breakdown in brain integration is the neural correlate of the loss of consciousness induced by propofol. They stress the important role played by parietal and frontal areas in the generation of consciousness. [less ▲]

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See detailCharacterization of the response of GFP microbial biosensors sensitive to substrate limitation in scale-down bioreactors
Delvigne, Frank ULg; Brognaux, Alison ULg; Gorret, Nathalie et al

in Biochemical Engineering Journal (2011), 55(2), 131-139

The dynamics of microbial stress response in intensive cultivation conditions remains not completely understood. In this work, two green fluorescent protein (GFP) transcriptional reporters have been used ... [more ▼]

The dynamics of microbial stress response in intensive cultivation conditions remains not completely understood. In this work, two green fluorescent protein (GFP) transcriptional reporters have been used as biosensors of the heterogeneities generated in a two-compartment scale-down reactor. The stress promoters have been chosen for their responsiveness to carbon limitation corresponding to the global substrate profiles encountered in intensive fed-batch cultures. From our results, it can be concluded that the exposure of microbial cells to substrates heterogeneities tends to decrease the GFP expression level in fed-batch mode. Fluorescence intensities have been monitored at the single cell level by using flow cytometry. During the course of the fed-batch culture, a drop at the level of the intracellular GFP content has been observed for the two scale-down operating conditions and for the two promoters sensitive to substrate limitation (rpoS and csiE). The fluorescence drop can be attributed to the repression of these promoters but also to the release of GFP to the extracellular medium according to the increase of the fluorescence level of the supernatant. This leakage has been observed for all the operating conditions, i.e. the scale-down reactors and the culture operating in the normal mode, i.e. in a well-mixed bioreactor. Interestingly, GFP leakage is more pronounced in the case of the cultures operated in the normal mode. Indeed, staining by propidium iodide tends to be more elevated for the microbial cells cultured under the normal mode by comparison with those cultured in scale-down conditions, indicating a higher permeability of the membrane. These results suggest that GFP microbial biosensors could be used to detect simultaneously mixing imperfections and their impact on the viability of microorganisms. [less ▲]

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See detailAn intermediate in the evolution of superfast sonic muscles.
Mok, H.; Parmentier, Eric ULg; Chiu, H. et al

in Frontiers in Zoology (2011), 8

Background Intermediate forms in the evolution of new adaptations such as transitions from water to land and the evolution of flight are often poorly understood. Similarly, the evolution of superfast ... [more ▼]

Background Intermediate forms in the evolution of new adaptations such as transitions from water to land and the evolution of flight are often poorly understood. Similarly, the evolution of superfast sonic muscles in fishes, often considered the fastest muscles in vertebrates, has been a mystery because slow bladder movement does not generate sound. Slow muscles that stretch the swimbladder and then produce sound during recoil have recently been discovered in ophidiiform fishes. Here we describe the disturbance call (produced when fish are held) and sonic mechanism in an unrelated perciform pearl perch (Glaucosomatidae) that represents an intermediate condition in the evolution of super-fast sonic muscles. Results The pearl perch disturbance call is a two-part sound produced by a fast sonic muscle that rapidly stretches the bladder and an antagonistic tendon-smooth muscle combination (part 1) causing the tendon and bladder to snap back (part 2) generating a higher-frequency and greater-amplitude pulse. The smooth muscle is confirmed by electron microscopy and protein analysis. To our knowledge smooth muscle attachment to a tendon is unknown in animals. Conclusion The pearl perch, an advanced perciform teleost unrelated to ophidiiform fishes, uses a slow type mechanism to produce the major portion of the sound pulse during recoil, but the swimbladder is stretched by a fast muscle. Similarities between the two unrelated lineages, suggest independent and convergent evolution of sonic muscles and indicate intermediate forms in the evolution of superfast muscles. [less ▲]

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See detailComparison between various methods for the evaluation of the fire resistance of concrete filled hollow steel columns
Fellah, Farid; Dotreppe, Jean-Claude ULg; Seridi, Ahcène et al

in Proceeding of the Romanian Academy. Series A, Mathematics, Physics, Technical Sciences, Information Science (2011), 12(4), 324-331

Hollow steel columns filled with bar-reinforced concrete are used extensively in the construction of high-rise buildings. Many research works devoted to the fire resistance of these profiles have been ... [more ▼]

Hollow steel columns filled with bar-reinforced concrete are used extensively in the construction of high-rise buildings. Many research works devoted to the fire resistance of these profiles have been performed in Europe and in North America. Though calculation methods are now proposed in codes, more practical tools are needed by the design engineers. It is not easy to develop such methods due to the large scatter of experimental results. In this article three methods based on quite different procedures are examined. Comparisons have been made between the results obtained by the three methods and test results. The potentialities of each method are examined, but also the domains in which they should be used with care, or even they should not be used. [less ▲]

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See detailEsophageal cancer surgery in patients older than 75: long term results.
HONORE, Charles ULg; Al-Azzeh, Ali ULg; GILSON, Nathalie ULg et al

in Acta Chirurgica Belgica (2011), 111(1), 12-7

PURPOSE: The purpose of this study was to evaluate short and long term results after esophageal cancer resection in patients older than 75. METHODS: We retrospectively analyzed the database of esophageal ... [more ▼]

PURPOSE: The purpose of this study was to evaluate short and long term results after esophageal cancer resection in patients older than 75. METHODS: We retrospectively analyzed the database of esophageal cancer surgically treated in our department between January 2003 and December 2009 to identify patients older than 75. The preoperative, operative, postoperative and long term characteristics were analyzed. RESULTS: Among 137 patient, 23 were older than 75. The histological subtype was adenocarcinoma in 100%. The surgical techniques were a "Lewis-Santy" procedure in 43%, a trans-hiatal resection in 22%, a "Sweet" procedure in 13%, a stripping in 13% and a McKeown procedure in 9%. The in-hospital postoperative mortality was 13%. The in-hospital postoperative morbidity (Dindo-Clavien Grade >2, deceased patients included) was 26%. In univariate analysis, no statistically significant risk factor of morbidity was found. A Charlson Comorbidity Index >2 was, in univariate analysis, the sole risk factor of postoperative mortality (p = 0.0362). The mean hospital stay was 22 +/- 12 days. The median survival was 24.2 months. The 5-year overall survival was 39% and the 5-year disease free survival was 26%.57% of long-term deaths were not cancer related. CONCLUSION: Esophageal surgery performed in selected patients older than 75 has an acceptable morbidity and mortality but when a severe complication occurs, it leads to death in half of the cases. Surgery enables a long term survival benefit. This study confirmed our attitude of not considering age as a contra-indication for esophageal surgery but rather considering general status, self-reliance and associated comorbidities for patients' selection. [less ▲]

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See detailEuropese rechtspraak : actualia
Durviaux, Ann-Lawrence ULg

in Marchés et Contrats Publics = Overheidsopdrachten en -Overeenkomsten (2011), 2011/3

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See detailA non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises
Weijs, Liesbeth; Covaci, Adrian; Yang, Raymond S. H. et al

in Toxicology and Applied Pharmacology (2011), 256

In the last decade, physiologically based pharmacokinetic (PBPK) models have increasingly been developed to explain the kinetics of environmental pollutants in wildlife. For marine mammals specifically ... [more ▼]

In the last decade, physiologically based pharmacokinetic (PBPK) models have increasingly been developed to explain the kinetics of environmental pollutants in wildlife. For marine mammals specifically, these models provide a new, non-destructive tool that enables the integration of biomonitoring activities and in vitro studies. The goals of the present study were firstly to develop PBPK models for several environmental relevant PCB congeners in harbor porpoises (Phocoena phocoena), a species that is sensitive to pollution because of its limited metabolic capacity for pollutant transformation. These models were tested using tissue data of porpoises from the Black Sea. Secondly, the predictive power of the models was investigated for time trends in the PCB concentrations in North Sea harbor porpoises between 1990 and 2008. Thirdly, attempts were made to assess metabolic capacities of harbor porpoises for the investigated PCBs. In general, results show that parameter values from other species (rodents, humans) are not always suitable in marine mammal models, most probably due to differences in physiology and exposure. The PCB 149 levels decrease the fastest in male harbor porpoises from the North Sea in a time period of 18†years, whereas the PCB 101 levels decrease the slowest. According to the models, metabolic breakdown of PCB 118 is probably of lesser importance compared to other elimination pathways. For PCB 101 and 149 however, the presence of their metabolites can be attributed to bioaccumulation of metabolites from the prey and to metabolic breakdown of the parent compounds in the harbor porpoises. [less ▲]

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See detailLe mécénat féminin en France et en Bourgogne (XVe-XVIe siècles). Nouvelles perspectives. Actes de la journée d'études internationale tenue à l'Université de Liège, le 10 mai 2010
Fagnart, Laure ULg; L'Estrange, Elizabeth

Book published by De Boeck (2011)

Le rôle joué par les femmes de pouvoir au Moyen Âge et au tout début de la Renaissance dans la commande d’œuvres artistiques et culturelles constitue un champ de recherche de plus en plus prolifique. La ... [more ▼]

Le rôle joué par les femmes de pouvoir au Moyen Âge et au tout début de la Renaissance dans la commande d’œuvres artistiques et culturelles constitue un champ de recherche de plus en plus prolifique. La présente collection d’articles, suscitée par une journée d’études intitulée "Le mécénat féminin en France et en Bourgogne (XVe-XVIe siècles). Nouvelles perspectives", qui a eu lieu à l’Université de Liège en 2010, illustre l’importance des femmes mécènes, en France et en Bourgogne, dans les domaines de l’architecture, de l’orfèvrerie, des manuscrits enluminés, de la peinture et de la sculpture, ainsi que dans la traduction et dans l’organisation des cérémonials. Dans leurs fonctions respectives, celles de reine, reine mère, duchesse, régente, dame d’honneur, les femmes font usage des œuvres d’art et des rites pour promouvoir leurs intérêts personnels et dynastiques, confrontées qu’elles sont aux difficultés liées à leur sexe et à leur statut de femme de pouvoir, ou à des difficultés telles que les rivalités, la guerre, ou la folie. Même s’il est clair que les cours française et bourguignonne constituent l’espace le plus favorable à l’efflorescence du mécénat féminin, cette collection démontre toutefois l’existence d’un même phénomène, important, en dehors des sphères royales. [less ▲]

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See detailAgathe de Catane (5 février), itinéraire d’un culte : de son martyre à la distribution de ses reliques
George, Philippe ULg

in Sant’Agata, Il reliquiario a busto. Contributi interdisciplinari. (2011)

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See detailRecherche sur la gestion des âges dans les entreprises belges
Hansez, Isabelle ULg; Faulx, Daniel ULg; Angenot, Arnaud ULg et al

Report (2011)

Face à la problématique du vieillissement au travail, ainsi qu’aux conséquences sociales et économiques auxquelles elle est associée, la nécessité de mettre en place une gestion des âges au sein des ... [more ▼]

Face à la problématique du vieillissement au travail, ainsi qu’aux conséquences sociales et économiques auxquelles elle est associée, la nécessité de mettre en place une gestion des âges au sein des entreprises est de plus en plus souvent mise en exergue. Cette gestion des âges, qui se veut intégrée, implique cependant une remise en question profonde des valeurs, des normes et de la culture d’entreprise. Associer le facteur « âge » aux politiques et pratiques de ressources humaines doit nécessairement s’accompagner d’un changement des mentalités et d’une meilleure intégration des générations au travail. C’est dans cette optique qu’une recherche sur la gestion des âges dans les entreprises belges a été commanditée, en 2010, par le Service Public Fédéral Emploi, Travail et Concertation sociale. Cette recherche a contribué au développement d’un guide de sensibilisation dont l’objectif était de constituer une aide à l’implémentation d’une gestion des âges efficace en entreprise. [less ▲]

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See detailImpact of chronic graft-versus-host disease (GVHD) after reduced intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) as treatment for acute myeloid leukemia (AML) : a survey from the Acute Leukemia Working Party of the EBMT
Baron, Frédéric ULg; Labopin, Myriam; Niederwieser, Dietger et al

in Blood (2011), 118

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients ... [more ▼]

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients (pts) who experienced chronic GVHD after RIC allo-SCT versus in those who did not. Here, we investigated the impact of occurrence of GVHD on transplantation outcomes in a large cohort of AML pts given allogeneic PBSC after RIC conditioning. Data from 1859 AML pts in first (n=1439) or second (n=420) CR transplanted between 2000 and 2009 following a RIC regimen at EBMT affiliated centres were analyzed. Pts were given PBSC from HLA-identical sibling (MRD, n=1208), or from HLA-matched unrelated donors (MUD, n=651). Median pt age at transplantation was 56 y (range, 18–77). 338 male pts were given grafts from female donors. RIC was based on low-dose TBI in 520 (28%) pts, while the remaining pts received chemotherapy-based RIC. ATG was given in 269 (22%) MRD and in 267 (41%) MUD recipients, respectively, while 151 (13%) MRD and 165 (25%) MUD recipients received in-vivo T cell depletion with alemtuzumab. The impact of chronic GVHD on relapse risk, non-relapse mortality (NRM), leukemia-free survival (LFS), and overall survival (OS) was assessed using time-dependent multivariate Cox models and in a landmark analysis at 18 months after transplant. Three-year incidences of relapse, NRM, LFS and OS were 34±1%, 15±1%, 51±2% and 60±2% in MRD recipients, respectively, and 34±2% (p=NS), 24±2% (P<0.001), 42±2% (P=0.001) and 47±2% (P=0.001) in MUD recipients, respectively. Grade II, III and IV acute GVHD were observed in 133 (11%), 61 (5%) and 30 (2%) MRD recipients and in 119 (18%), 41 (6%) and 24 (4%) MUD recipients, respectively. The 3-y cumulative incidence of chronic GVHD was 47%. Fifty-three percent of patients with chronic GVHD had extensive chronic GVHD, while the remaining 47% had limited chronic GVHD. In multivariate analyses, occurrence of grade II-IV acute GVHD was associated with a lower risk of relapse (HR=0.8; P=0.04), a higher risk of chronic (HR=2.2; P<0.001) and extensive chronic GVHD (HR=2.8; P<0.001), a higher risk of NRM (HR=2.4 P<0.001), a worsened LFS (HR=1.3; P=0.01), and a worsened OS (HR=1.5; P<0.001). In multivariate time-dependent analyses, occurrence of limited chronic GVHD was associated with a lower risk of relapse (HR=0.7; P=0.05), comparable NRM (HR=1.4; P=0.16), comparable LFS (HR=0.9; P=0.29) and better OS (HR=0.5; P<0.001), while occurrence of extensive chronic GVHD was associated with a lower risk of relapse (HR=0.6; P=0.01), higher NRM (HR=3.2; P<0.001), a trend for worsened LFS (HR=1.3; P=0.06) and comparable OS (HR=0.9; P=0.34). The median interval from transplantation to occurrence of chronic GVHD was 163 (range, 100–1545) days. To further assess the graft-versus-leukemia effect of chronic GVHD, we performed a landmark analysis in patients who were leukemia-free at 18 months after transplantation (n=776). Median follow-up from this landmark time-point was 24 (range, 0.1–112) months. Two-year relapse, NRM, LFS and OS were 16±2%, 2.5±1%, 82±2%, and 89±2%, respectively, in patients without chronic GVHD before the landmark time-point, versus 9±1% (P=0.001), 8±1% (P<0.001), 83±2% (P=0.65), and 86±2% (P=0.38), respectively, in patients with chronic GVHD before the landmark time-point.In conclusion, in this cohort of AML patients transplanted in remission, occurrence of chronic GVHD was associated with a lower risk of relapse that translated to better OS in patients with limited chronic GVHD but not in those with extensive chronic GVHD who experienced higher long term NRM, highlighting the need for long term prospective assessment of long term effects and quality of life in patients receiving RIC allo-SCT. [less ▲]

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