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See detailDescription of the bone-remodeling pattern after socket preservation procedures in human: a methodological study
LAMBERT, France ULg; VINCENT, Kim ULg; VANHOUTTE, Vanessa ULg et al

Poster (2011)

Background: The bone remodeling after tooth extraction can result in the loss of as much as 50% of the buccal wall and a global crestal reduction in width of 3.87mm according to a recent systematic review ... [more ▼]

Background: The bone remodeling after tooth extraction can result in the loss of as much as 50% of the buccal wall and a global crestal reduction in width of 3.87mm according to a recent systematic review. Multiple surgical protocols using biomaterials are proposed in order to limit the typical postextraction bone resorption. However, because of the heterogeneity of the studies and, more specifically, of the assessment methods, it is difficult to assert the superiority of one technique over another. Aim: The objective of this study was to develop a new radiographic method to assess alveolar bone remodeling after socket preservation procedures. Methods: Sixteen extraction sites (in 14 patients) localized in the upper anterior maxilla were treated with bovine hydroxyapatite (0.25–1mm particles) and a saddled connective tissue graft. A radiographic 3-dimensional assessment of the hard tissues was performed at baseline and at 3 months after the procedure. Standardized horizontal measurements were taken at three corono apical levels ( 2, 5, and 9mm) and at three mesio-diatal level (Mesial, Center, and Distal) in the buccal and palatal aspects. Vertical measurements were also recorded in nine regions over the top of the alveolar crest. Results: Extraction socket-preservation technique assessed in the present study significantly reduced horizontal bone remodeling. The horizontal dimension of the crest decreased by 1.6mm (20%) in the cervical regions ( 2mm level), experienced a moderate decrease of 1mm (12%) at the 5mm level, and experienced a very low decrease of 0.5mm(6%) in the apical ( 8mm) level. The losses were always significantly higher in the buccal than in the palatal aspect. Buccally, the maximal bone remodeling at the cervical level remained below 1mm. Vertical bone resorption was homogeneous and was < 1mm in the nine measured regions. Conclusions and clinical implications: The radiographic measuring methodology proved to be accurate and reproducible. It can be applied in other clinical settings. Moreover, the surgical procedure evaluated in the present study, significantly limits the postextraction buccal bone remodeling compared with the data found in the literature for untreated extraction socket in the aesthetic area. However, a complete inhibition of the bone remodeling was not reached and the authors suggest a surgical technique using a ‘‘saddled’’ connective tissue graft to thicken buccal soft tissue biotype and consequently compensate for cervical bone loss. [less ▲]

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See detailRegM - Registre de Morbidité
Vanmeerbeek, Marc ULg; Franckh, Marc; Froidcoeur, Xavier ULg

Report (2011)

REGM is a research program about the feasibility of a Belgian morbidity registration system, extracted from existing electronic information systems (EMR) of general practitioners. REGM is part of a larger ... [more ▼]

REGM is a research program about the feasibility of a Belgian morbidity registration system, extracted from existing electronic information systems (EMR) of general practitioners. REGM is part of a larger program which aims to enhance the development of primary health care and improve the quality of care. This part is aimed at the description of three experiments: in France, Switzerland and the Netherlands. [less ▲]

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See detailLe centre, les planètes et la noirceur : Controverses cosmiques et terrestres
Nazé, Yaël ULg

Article for general public (2011)

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See detailField trip 1: Givetian and Frasnian of Southern Belgium
Boulvain, Frédéric ULg; Coen-Aubert, Marie; Da Silva, Anne-Christine ULg et al

in Kölner Forum für Geologie und Paläontologie (2011), 20

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See detailCompetitive facility location problem with attractiveness adjustment of the follower: A bilevel programming model and its solution
Kucukaydin, Hande ULg; Aras, Necati; Altinel, I. Kuban

in European Journal of Operational Research (2011), 208(3), 206-220

We are concerned with a problem in which a firm or franchise enters a market by locating new facilities where there are existing facilities belonging to a competitor. The firm aims at finding the location ... [more ▼]

We are concerned with a problem in which a firm or franchise enters a market by locating new facilities where there are existing facilities belonging to a competitor. The firm aims at finding the location and attractiveness of each facility to be opened so as to maximize its profit. The competitor, on the other hand, can react by adjusting the attractiveness of its existing facilities with the objective of maximizing its own profit. The demand is assumed to be aggregated at certain points in the plane and the facilities of the firm can be located at predetermined candidate sites. We employ Huff's gravity-based rule in modeling the behavior of the customers where the fraction of customers at a demand point that visit a certain facility is proportional to the facility attractiveness and inversely proportional to the distance between the facility site and demand point. We formulate a bilevel mixed-integer nonlinear programming model where the firm entering the market is the leader and the competitor is the follower. In order to find the optimal solution of this model, we convert it into an equivalent one-level mixed-integer nonlinear program so that it can be solved by global optimization methods. Apart from reporting computational results obtained on a set of randomly generated instances, we also compute the benefit the leader firm derives from anticipating the competitor's reaction of adjusting the attractiveness levels of its facilities. The results on the test instances indicate that the benefit is 58.33% on the average. [less ▲]

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See detailCoordination of verbal dependents in Old French : Coordination as a specified juxtaposition or apposition
Mazziotta, Nicolas ULg

in Gerdes, Kim; Hajičova, Eva; Wanner, Leo (Eds.) Proceedings of Depling 2011, International Conference on Dependency Linguistics, Barcelona (2011)

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See detailDe l'utilité d'une consultation conjointe de gynécologie- endocrinologie pédiatrique : étude rétrospective des motifs de consultation et approche pratique
HARVENGT, Julie ULg; Retz, M.-C.; Foidart, Jean-Michel ULg et al

in Revue Médicale de Liège (2011), 66(11), 581-8

The gynaecological issues encountered in children and teenagers lay at the intersection of paediatric endocrinology and gynaecology. More than ten years ago, an outpatient clinic in paediatric ... [more ▼]

The gynaecological issues encountered in children and teenagers lay at the intersection of paediatric endocrinology and gynaecology. More than ten years ago, an outpatient clinic in paediatric endocrinology and gynaecology has been created. Here, we review the last 6 years. 214 girls were included, considering only the first visit for each patient. Collected data are initial concern for this consultation, age at first consultation and confirmed or suspected diagnosis. A classification is done according to the initial concern of patients in six categories. Principal queries concern pubertal development, precocious pilosity or abnormalities in menstrual cycles. Vulvovaginitis and morphologic abnormalities are also frequently encountered. This consultation suggests a paediatric approach with a child feeling confident and a gynaecological examination with a specialist knowing the anatomy particularities and the development of the children. This article focuses on the importance of specific gynaecological examination in children and reviews the main diseases encountered. [less ▲]

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See detail1D numerical modeling of the flow over a Piano Key Weir
Erpicum, Sébastien ULg; Machiels, Olivier ULg; Archambeau, Pierre ULg et al

in Erpicum, Sébastien; Laugier, Frédéric; Boillat, Jean Louis (Eds.) et al Labyrinth and Piano Key Weirs - PKW 2011 (2011)

Because of the PK-Weir geometric specificities, its hydraulic capacity remains difficult to predict without using experimental techniques. A 1D numerical model of the flow over a PK-Weir has been ... [more ▼]

Because of the PK-Weir geometric specificities, its hydraulic capacity remains difficult to predict without using experimental techniques. A 1D numerical model of the flow over a PK-Weir has been developed at the Research unit HACH at the University of Liege. It is based on a 1D modeling of the inlet and the outlet separately, with a single upstream reservoir and interactions between both flows by exchange of mass and momentum along the lateral crest. The comparison of the numerical results with various experimental data showed the ability of the numerical model to predict with reasonable accuracy the release capacity of a PK-Weir, whatever its geometry. The tests of the solver enable to highlight the significant influence of the inlet and outlet width on the weir release capacity. They also suggest that improvements of the numerical model may lie in the evaluation of the discharge coefficient of the lateral crest. [less ▲]

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See detailGait feature extraction in Parkinson's disease using low-cost accelerometers
Stamatakis, Julien; Cremers, Julien ULg; Maquet, Didier ULg et al

Poster (2011)

The clinical hallmarks of Parkinson’s disease (PD) are movement poverty and slowness (i.e. bradykinesia), muscle rigidity, limb tremor or gait disturbances. Parkinson’s gait include slowness, shuffling ... [more ▼]

The clinical hallmarks of Parkinson’s disease (PD) are movement poverty and slowness (i.e. bradykinesia), muscle rigidity, limb tremor or gait disturbances. Parkinson’s gait include slowness, shuffling, short steps, freezing of gait (FoG) and/or asymmetries in gait. There are currently no validated clinical instruments or device that allow a full characterization of gait disturbances in PD. As a step towards this goal, a four accelerometer-based system is proposed to increase the number of parameters that can be extracted to characterize parkinsonian gait disturbances such as FoG or gait asymmetries. After developing the hardware, an algorithm has been developed, that automatically epoched the signals on a stride-by-stride basis and quantified, among others, the gait velocity, the stride time,the stance and swing phases, the single and double support phases or the maximum acceleration at toe-off, as validated by visual inspection of video recordings during the task. The results obtained in a PD patient and an healthy volunteer are presented. The FoG detection will be improved using time-frequency analysis and the system is about to be validated with a state-of-the-art 3D movement analysis system. [less ▲]

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See detailOptimal linear taxation under endogenous longevity
Pestieau, Pierre ULg; Leroux, ML; Ponthiere, Gregory

in Journal of Population Economics (2011), 24

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See detailAntibody production by injection of living cells expressing non self antigens as cell surface type II transmembrane fusion protein.
Nizet, Yannick; Gillet, Laurent ULg; SCHROEDER, Hélène ULg et al

in Journal of immunological methods (2011)

Antigen expression and purification are laborious, time consuming and frequently difficult steps in the process of antibody production. In the present study, we developed a method avoiding these two steps ... [more ▼]

Antigen expression and purification are laborious, time consuming and frequently difficult steps in the process of antibody production. In the present study, we developed a method avoiding these two steps. This method relies on the injection of histocompatible living cells stably expressing the antigen as a cell surface type II transmembrane fusion protein. A vector, nicknamed pCD1-CD134L, was constructed to express the antigen fused at the carboxyterminal end of the human CD134 ligand (CD134L) type II transmembrane protein on the surface of eucaryotic cells. This vector was shown to induce cell surface expression of epitopes from human c-Myc (soluble protein), uterogloblin-related protein 1 (secreted protein) and CD94 (type II transmembrane protein). Using this vector, we developed a method to produce antibodies without antigen production. The flowchart of this method is as follows: (i) cloning of the antigen in the pCD1-CD134L vector; (ii) production of a histocompatible cell line stably expressing the CD134L-antigen fusion protein; (iii) testing for cell surface expression of the fusion protein by targeting the CD134L carrier; and (iv) prime-boost immunisation with living cells expressing the fusion protein. This method was successfully used for production of polyclonal antibodies raised against Ixodes ricinus calreticulin (secreted protein) in mice and for production of monoclonal antibodies raised against an epitope of Vaccinia virus A56 (type I transmembrane protein) protein in rat. The present study is the first to demonstrate the use of a type II transmembrane protein as a carrier for cell surface display of antigens. [less ▲]

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See detailChlamydomonas can play a role in the study of a heteroplasmic human mitochondrial mutation
Larosa, Véronique ULg; Coosemans, Nadine ULg; Bonnefoy, Nathalie et al

Scientific conference (2011)

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See detailYBa2Cu3O7−x dispersion in iodine acetone for electrophoretic deposition: Surface charging mechanism in a halogenated organic media
Dusoulier, Laurent; Cloots, Rudi ULg; Vertruyen, Bénédicte ULg et al

in Journal of the European Ceramic Society (2011), 31

Electrophoretic deposition (EPD) performance strongly depends on the particles surface chemistry and the ability to manipulate surface–liquid interfaces. In this study an extensive investigation of YBCO ... [more ▼]

Electrophoretic deposition (EPD) performance strongly depends on the particles surface chemistry and the ability to manipulate surface–liquid interfaces. In this study an extensive investigation of YBCO suspension in dry acetone, acetone–water mixtures and acetone–iodine is reported. Chemical instability of YBCO particles determines their colloidal behaviour. Charging mechanism of particles has therefore had to be deeply investigated for complete dispersion understanding. In order to determine the conditions of the YBCO suspension stability, measurements of pH, conductivity, zeta-potential, settling tests, modelling of the particle networks and electrophoretic deposition were done. The influence of the water and iodine concentration, and their role as stabilizers was evaluated. Based on experimental results, pair particle potentials were calculated and then different charging mechanisms of YBCO surfaces in acetone were proposed. [less ▲]

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See detailSentiment d’altérité dans la correspondance de Rousseau en 1762
Biquet, Stéphanie ULg

in Turekova, Andrea (Ed.) Conférence internationale Autre - Autrui - Altérité (2011)

Jean-Jacques Rousseau est né avec la conscience de son altérité : fils d’horloger, citoyen de Genève, il se sent dès son plus jeune âge différent du monde qui l’entoure. Par sa « réforme » au début des ... [more ▼]

Jean-Jacques Rousseau est né avec la conscience de son altérité : fils d’horloger, citoyen de Genève, il se sent dès son plus jeune âge différent du monde qui l’entoure. Par sa « réforme » au début des années 1750, il transformera officiellement cette altérité en faire-valoir. Pourtant, quand résonne le glas de la condamnation de ses œuvres (Émile et le Contrat social) en 1762, l’homme jusque-là différent, se sent étranger, incompris, seul contre tous, comme en témoigne sa correspondance. Cet article se donne pour objectif d’étudier ce sentiment d’altérité et d’étrangeté à travers la correspondance personnelle de Jean-Jacques Rousseau de 1762 à 1765 (soit de la condamnation de l’Émile et du Contrat social jusqu'au départ pour l’Angleterre chez David Hume). [less ▲]

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See detailCHIC cells: a novel ALK+ cell line derived from a relapsed anaplastic large cell lymphoma
Thielen, Caroline ULg; Bisig, Bettina ULg; Gofflot, Stéphanie ULg et al

in British Journal of Haematology (2011), 152

Since the initial description of anaplastic large cell lymphoma (ALCL) as a proliferation of large CD30+ lymphoid cells, the morphological spectrum of ALCL positive for anaplastic lymphoma kinase (ALCL ... [more ▼]

Since the initial description of anaplastic large cell lymphoma (ALCL) as a proliferation of large CD30+ lymphoid cells, the morphological spectrum of ALCL positive for anaplastic lymphoma kinase (ALCL, ALK+) has expanded, and beyond the common pattern most frequently encountered, several variants have been identified, including the lymphohistiocytic and the small cell patterns (Swerdlow et al, 2008). Only ten ALK+ ALCL cell lines are currently available, and most were derived from tumours demonstrating the common type morphology (Drexler & MacLeod, 2004). We have established a novel cell line (CHIC) from the cerebrospinal fluid of a 32-year-old man with relapsing/refractory ALK+ ALCL with a t(2;5)(p23;q35) translocation whose initial tumour exhibited lymphohistiocytic features. This cell line is now made available to the scientific community. In addition to multiple in vitro applications, the tumourigenic capacity of these cells represents a useful property for in vivo drug testing. [less ▲]

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See detailLe modèle de croissance katangais face à la crise financière mondiale : enjeux en termes d'emploi
Lapeyre, Frédéric; Lebailly, Philippe ULg; Musewa M'Bayo, Laki et al

Book published by Bureau International du Travail (2011)

La crise financière mondiale qui a éclaté en 2008 et les effets désastreux qu’elle a occasionnés sur le secteur minier en RDC (qui avait été placé au centre des politiques de croissance et de lutte contre ... [more ▼]

La crise financière mondiale qui a éclaté en 2008 et les effets désastreux qu’elle a occasionnés sur le secteur minier en RDC (qui avait été placé au centre des politiques de croissance et de lutte contre la pauvreté) posent avec encore plus d’acuité la question de la diversification de la structure économique dans une province comme le Katanga. Au problème de la vulnérabilité d’un tel modèle de croissance s’ajoute le constat qui est fait dans cette étude du manque d’effet d’entrainement de l’activité des grands groupes miniers sur le reste de l’économie locale, en termes de développement des capacités productives et de création d’emplois. [less ▲]

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See detailModel of the Jovian magnetic field topology constrained by the Io auroral emissions
Hess, S. L. G.; Bonfond, Bertrand ULg; Zarka, P. et al

in Journal of Geophysical Research. Space Physics (2011), 116

The determination of the internal magnetic field of Jupiter has been the object of many studies and publications. These models have been computed from the Pioneer, Voyager, and Ulysses measurements. Some ... [more ▼]

The determination of the internal magnetic field of Jupiter has been the object of many studies and publications. These models have been computed from the Pioneer, Voyager, and Ulysses measurements. Some models also use the position of the Io footprints as a constraint: the magnetic field lines mapping to the footprints must have their origins along Io's orbit. The use of this latter constraint to determine the internal magnetic field models greatly improved the modeling of the auroral emissions, in particular the radio ones, which strongly depends on the magnetic field geometry. This constraint is, however, not sufficient for allowing a completely accurate modeling. The fact that the footprint field line should map to a longitude close to Io's was not used, so that the azimuthal component of the magnetic field could not be precisely constrained. Moreover, a recent study showed the presence of a magnetic anomaly in the northern hemisphere, which has never been included in any spherical harmonic decomposition of the internal magnetic field. We compute a decomposition of the Jovian internal magnetic field into spherical harmonics, which allows for a more accurate mapping of the magnetic field lines crossing Io, Europa, and Ganymede orbits to the satellite footprints observed in UV. This model, named VIPAL, is mostly constrained by the Io footprint positions, including the longitudinal constraint, and normalized by the Voyager and Pioneer magnetic field measurements. We show that the surface magnetic fields predicted by our model are more consistent with the observed frequencies of the Jovian radio emissions than those predicted by previous models. [less ▲]

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See detailComment arriver à la prothèse pénienne
Andrianne, Robert ULg

Scientific conference (2011)

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See detailHTLV-1 propels thymic human T cell development in "human immune system" Rag2(-)/(-) gamma c(-)/(-) mice.
Villaudy, Julien; Wencker, Melanie; Gadot, Nicolas et al

in PLoS Pathogens (2011), 7(9), 1002231

Alteration of early haematopoietic development is thought to be responsible for the onset of immature leukemias and lymphomas. We have previously demonstrated that Tax(HTLV-1) interferes with ss-selection ... [more ▼]

Alteration of early haematopoietic development is thought to be responsible for the onset of immature leukemias and lymphomas. We have previously demonstrated that Tax(HTLV-1) interferes with ss-selection, an important checkpoint of early thymopoiesis, indicating that human T-cell leukemia virus type 1 (HTLV-1) infection has the potential to perturb thymic human alphabeta T-cell development. To verify that inference and to clarify the impact of HTLV-1 infection on human T-cell development, we investigated the in vivo effects of HTLV-1 infection in a "Human Immune System" (HIS) Rag2(-)/(-)gamma(c)(-)/(-) mouse model. These mice were infected with HTLV-1, at a time when the three main subpopulations of human thymocytes have been detected. In all but two inoculated mice, the HTLV-1 provirus was found integrated in thymocytes; the proviral load increased with the length of the infection period. In the HTLV-1-infected mice we observed alterations in human T-cell development, the extent of which correlated with the proviral load. Thus, in the thymus of HTLV-1-infected HIS Rag2(-)/(-)gammac(-)/(-) mice, mature single-positive (SP) CD4(+) and CD8(+) cells were most numerous, at the expense of immature and double-positive (DP) thymocytes. These SP cells also accumulated in the spleen. Human lymphocytes from thymus and spleen were activated, as shown by the expression of CD25: this activation was correlated with the presence of tax mRNA and with increased expression of NF-kB dependent genes such as bfl-1, an anti-apoptotic gene, in thymocytes. Finally, hepato-splenomegaly, lymphadenopathy and lymphoma/thymoma, in which Tax was detected, were observed in HTLV-1-infected mice, several months after HTLV-1 infection. These results demonstrate the potential of the HIS Rag2(-)/(-)gamma(c)(-)/(-) animal model to elucidate the initial steps of the leukemogenic process induced by HTLV-1. [less ▲]

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