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See detailEvaluation of organic dust components cytotoxicity on thp1 monocytes-derived-macrophages using high content analysis
Ramery, Eve ULg; O'Brien, Peter James

in Veterinary Clinical Pathology (2011, December), 40(4), 583

Background: Organic dust contains pathogen associated molecular patterns (PAMPs) which can induce, following chronic exposure, significant airway diseases. Mononuclear phagocytes are key protecting cells ... [more ▼]

Background: Organic dust contains pathogen associated molecular patterns (PAMPs) which can induce, following chronic exposure, significant airway diseases. Mononuclear phagocytes are key protecting cells of the respiratory tract. Several studies have investigated the effects of PAMPs, and mainly endotoxins, on cytokine production. However the sub-lethal cytotoxicity of organic dust components on macrophages has not been tested yet. The novel technology of high content analysis (HCA) is already used to assess subclinical drug-induced toxicity. It combines the capabilities of flow cytometry, intracellular fluorescence probes, and image analysis and enables to perform rapid multiple analysis in large numbers of samples. Objectives: The purpose of the present study was, by using HCA, to investigate the cytotoxicity of the 3 major PAMPs contained in organic dust, ie. endotoxin (LPS), peptidoglycan (PGN) and β-glucans (zymosan) on THP-1 monocyte-derived macrophages. Methods: LPS was used at concentrations of 0.005, 0.01, 0.02, 0.05, 0.1 and 1 μg/ml; PGN and zymosan were used at concentrations of 1, 5, 10, 50, 100 and 500 μg/ml. Cells were exposed to PAMPs for 24 hours. In addition, the oxidative burst and the phagocytic capabilities of the cells were tested. Results: An overlap between PGN intrinsic fluorescence and red/far-red fluorescent dyes occurred, rendering the evaluation of some parameters impossible for PGN. LPS induced sub-lethal cytotoxicity at the lowest dose (from 10 ng/ml). However, the most spectacular changes occurred with zymosan. In addition, zymosan, but not LPS, induced phagosome maturation and oxidative burst. Conclusions: Given the fact that β-glucans can be up to 100 fold more concentrated in organic dust than LPS, these results suggest that β-glucans could play a major role in macrophages impairment following heavy dust exposure and will deserve further investigation in the near future. [less ▲]

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See detailFibrosis and pulmonary function tests - New therapeutic options for respiratory diseases.
Clercx, Cécile ULg

in Proceedings of the Meeting of German specialists in internal medicine (ECVIM-CA-Internal Medicine) - Viernheim - 3rd December 2011 (2011, December)

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See detailMatching an oscillator model to a phase response curve
Sacré, Pierre ULg; Sepulchre, Rodolphe ULg

in Proceedings of the Joint 50th IEEE Conference on Decision and Control and European Control Conference (2011, December)

The Phase Response Curve (PRC) has proven a useful tool for the reduction of complex oscillator models. It is also an information often experimentally available to the biologist. This paper introduces a ... [more ▼]

The Phase Response Curve (PRC) has proven a useful tool for the reduction of complex oscillator models. It is also an information often experimentally available to the biologist. This paper introduces a numerical tool based on the sensitivity analysis of the PRC to adapt initial model parameters in order to match a particular PRC shape. We illustrate the approach on a simple biochemical model of circadian oscillator. [less ▲]

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See detailChronique bibliographique - 2005-2008
Veymiers, Richard ULg; Bricault, Laurent; Budischovsky, Marie-Christine et al

in Bricault, Laurent; Veymiers, Richard (Eds.) Bibliotheca Isiaca II (2011)

Chronique bibliographique qui, sur le modèle de "l’Inventaire Bibliographique des Isiaca" (IBIS), publié dans les "ÉPRO" entre 1972 et 1991, recense, avec un commentaire critique, les publications ... [more ▼]

Chronique bibliographique qui, sur le modèle de "l’Inventaire Bibliographique des Isiaca" (IBIS), publié dans les "ÉPRO" entre 1972 et 1991, recense, avec un commentaire critique, les publications touchant aux cultes isiaques entre 2005 et 2008. [less ▲]

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See detailExtinctions et renouvellements fauniques chez les reptiles marins du Crétacé
Bardet, Nathalie; Fischer, Valentin ULg; Jouve, Stéphane et al

Conference (2011, December)

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See detailConstrained sparse estimation for improved fault isolation
Borguet, Sébastien ULg; Léonard, Olivier ULg

in Journal of Engineering for Gas Turbines & Power (2011), 133(12), 121602

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See detailEntretien avec David Toscana
Vanden Berghe, Kristine ULg

in Caravelle : Cahiers du Monde Hispanique et Luso-Bresilien (2011), 97(2), 241-248

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See detailNovel amphiphilic mikto-arm star-shaped copolymers for the preparation of PLA-based nanocarriers
Cajot, Sébastien ULg; Riva, Raphaël ULg; Billiet, Leen et al

in Macromolecular Symposia (2011), 309/310(1), 111-122

Three-arm (A2B) and four-arm (A2B2) star-shaped copolymers based on biocompatible and biodegradable hydrophobic poly(ε-caprolactone) (PCL) (A arms) and biocompatible and bioeliminable hydrophilic poly ... [more ▼]

Three-arm (A2B) and four-arm (A2B2) star-shaped copolymers based on biocompatible and biodegradable hydrophobic poly(ε-caprolactone) (PCL) (A arms) and biocompatible and bioeliminable hydrophilic poly(ethylene oxide) (PEO) (B arms) were synthesized by the coupling of an ω-azide terminated PEO chains with PCL chain bearing one (A2B) or two (A2B2) alkyne functions at the middle of the chain by the copper mediated azide-alkyne cycloaddition (CuAAC). The amphiphilic behavior of these different stars was confirmed by micellization experiments in water followed by dynamic light scattering and transmission electron microscopy analyses. The efficiency to stabilize PLA nanoparticles was investigated in function of the stars structure. [less ▲]

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See detailIntermediaries, transport costs and interlinked transactions
Lefevre, Mélanie ULg

Conference (2011, December)

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See detailLow-rank optimization for distance matrix completion
Mishra, Bamdev ULg; Meyer, Gilles ULg; Sepulchre, Rodolphe ULg

in Proceedings of the 50th IEEE Conference on Decision and Control (2011, December)

This paper addresses the problem of low-rank distance matrix completion. This problem amounts to recover the missing entries of a distance matrix when the dimension of the data embedding space is possibly ... [more ▼]

This paper addresses the problem of low-rank distance matrix completion. This problem amounts to recover the missing entries of a distance matrix when the dimension of the data embedding space is possibly unknown but small compared to the number of considered data points. The focus is on high-dimensional problems. We recast the considered problem into an optimization problem over the set of low-rank positive semidefinite matrices and propose two efficient algorithms for low-rank distance matrix completion. In addition, we propose a strategy to determine the dimension of the embedding space. The resulting algorithms scale to high-dimensional problems and monotonically converge to a global solution of the problem. Finally, numerical experiments illustrate the good performance of the proposed algorithms on benchmarks. [less ▲]

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See detailLa sémiotique, entre autres / Semiotics, among others
Dondero, Maria Giulia ULg; Provenzano, François ULg; Klinkenberg, Jean-Marie ULg et al

in Signata. Annales des Sémiotiques = Annals of Semiotics (2011), 2

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See detailLotze en Amérique. Le renouveau réaliste en philosophie chez Santayana
Boccaccini, Federico ULg

Conference (2011, December)

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See detailLayering of Size and Type Noun Constructions in English
Brems, Lieselotte ULg

Book published by Mouton de Gruyter - 1st (2011)

On the basis of synchronic and diachronic data analysis, the volume takes a close look at the synchronic layers of binominal size noun and type noun uses (a bunch/a load of X; a sort of X; a Y type of X ... [more ▼]

On the basis of synchronic and diachronic data analysis, the volume takes a close look at the synchronic layers of binominal size noun and type noun uses (a bunch/a load of X; a sort of X; a Y type of X) and reconsiders the framework of grammaticalization in view of issues raised by the phrases under discussion. As a result, a construction grammar-approach to grammaticalization is developed which does justice to the syntagmatic lexical, or collocational, reclustering observed in the data within an eclectic cognitive-functional approach. Prices subject to change. Shipping costs will be added. Current pricing is based [less ▲]

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See detailEffets de la pression partielle en hydrogène sur la production anaérobie de bioH2 par une bactérie chimiotrophe du genre Clostridium dans un nouveau réacteur à cylindre horizontal rotatif.
Beckers, Laurent ULg; Hiligsmann, Serge ULg; Hamilton, Christopher ULg et al

in Récents Progrès en Génie des Procédés (2011, December), 101

Hydrogen is widely considered as the most promising energetic carrier. At an industrial scale, steam reforming of methane is currently the major hydrogen producing process. But it may also be produced ... [more ▼]

Hydrogen is widely considered as the most promising energetic carrier. At an industrial scale, steam reforming of methane is currently the major hydrogen producing process. But it may also be produced from renewable biomass. Indeed, the fermentative production of hydrogen from renewable biomass using anaerobic bacteria could at least partially reduce our dependence on fossil fuel, decrease the carbon dioxide emissions and produce “green” energy. It offers the potential production of usable hydrogen from a variety of renewable resources such as carbohydrates wastes from agriculture or agro-food industries. This technology is based on anaerobic fermentation, called dark fermentation, by chemotrophic bacteria. The investigations carried out at CWBI involve selection and characterization of bacteria strains able to produce biohydrogen efficiently and with a wide range of substrate. The selected strains at the laboratory has been characterised as Clostridium sp. In order to produce hydrogen at high yields and production rates, the biotechnological process needs to be further optimized and efficient bioreactors must be designed. At CWBI, a new reactor called “horizontal rotating cylinder bioreactor” allows the production of biohydrogen from glucose with our Clostridium sp. strain with a high yield and production rate. This reactor, working continuously, has an internal volume of 2.3l but a working volume (liquid phase) of 300ml. Firstly, it enhances the hydrogen production rate by partially fixing the bacteria on the porous cylinder and thus increasing the cell concentration in the bioreactor. Secondly, the rotative cylinder enables efficient gas transfer (mainly hydrogen) from the liquid phase where it is produced by the bacteria. This is an important way to enhance hydrogen production yield by allowing the bacteria metabolism to shift in a fermentation type that produces more hydrogen. This was confirmed by increasing or decreasing the total pressure in the bioreactor and observing the influence of hydrogen production. The liquid to gas hydrogen transfer is possibly an important factor to enhance the biogas production. Our investigation confirmed this by testing different liquid to gas transfer condition in BHP test (batch fermentation in 250ml serum bottles).This was made either by decreasing total and partial pressure or by increasing the mixing state of the media. Our work concludes the importance of providing good liquid to gas transfers in the biohydrogen producing reactors to enhance the hydrogen production and reach higher yields and production rates. [less ▲]

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See detailIs hepatitis E virus zoonotic?
Thiry, Damien ULg

Conference (2011, December)

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See detailRapport d'activité du projet Health CoP 2011
Denis, Brigitte ULg; Snoeck, Céline ULg

Report (2011)

Rapport d'activité en lien avec les actions menées en milieu hospitalier. Création et animation de communautés de pratique supportées par les TIC.

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See detailEN1198-5 training : computation examples
Cerfontaine, Benjamin ULg

Conference given outside the academic context (2011)

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See detailCybercontestation tunisienne
Lecomte, Romain ULg

Article for general public (2011)

Les récents soulèvements arabes ont conduit nombre de journalistes et experts à se focaliser sur le rôle décisif d'Internet dans les mobilisations. Autant les usages contestataires d'Internet dans le ... [more ▼]

Les récents soulèvements arabes ont conduit nombre de journalistes et experts à se focaliser sur le rôle décisif d'Internet dans les mobilisations. Autant les usages contestataires d'Internet dans le monde arabe étaient jusque là largement ignorés, par les médias traditionnels (occidentaux ou non) mais aussi par le monde académique, autant désormais on observe une surenchère sur le rôle révolutionnaire des médias sociaux, souvent agrémentés de titres accrocheurs : « Révolution 2.0. », « Révolution Facebook », « Cyber-révolution »... À partir d'une recherche de doctorat portant sur les usages citoyens et contestataires d'Internet par les Tunisiens, je souhaiterais ici apporter un éclairage plus nuancé sur le rôle d'Internet dans ce petit pays du Maghreb où le « printemps arabe » est né, en prenant en considération à la fois son importance et ses limites. Je commencerai par poser le contexte contraignant dans lequel les internautes tunisiens devaient évoluer sous le régime de Ben Ali. Ensuite, je retracerai l'évolution des usages citoyens et contestataires d'Internet depuis la fin des années 90 jusqu'à aujourd'hui. Enfin, à la lumière de cette courte mais déjà riche histoire, je proposerai quelques éléments d'analyse du rôle d'Internet dans la conjoncture critique de décembre 2010-janvier 2011 en Tunisie. [less ▲]

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See detailMorphological and histological studies of sheep’s brain
Salouci, Moustafa ULg; Engelen, Virginie; Jacqmot, Olivier ULg et al

Poster (2011, December)

Introduction: The study of normal structures of the sheep’s brain is very important to understand pathological changes caused by the bluetongue virus in the fetus’s brain at various stages of the ... [more ▼]

Introduction: The study of normal structures of the sheep’s brain is very important to understand pathological changes caused by the bluetongue virus in the fetus’s brain at various stages of the gestation. Bluetongue is an arthropod-borne viral disease of domestic and wild ruminants. The serotype 8 is responsible for outbreaks in Northern Europe in 2006. This virus causes lesions in the brain of fetuses as hydrancephaly and porencephaly. The aim of this work is to improve knowledge of anatomy and histology of the central nervous system of the sheep. Methods: Seven heads of adult sheep and one from a fetus aged 4,5 months were used. All heads were first opened in the frontal area using bone’s saw and immerged in a formalin solution for 10 days. After a good fixation, the brains were extracted and sectioned. Transversal, frontal and sagittal sections were realized. The sections of two brains were stained with Berlin-blue and treated to be embedded in methylmetacrylate for gross morphology. The different parts of the 6 resting brains were then embedded in paraffin, cut and the histological sections were stained with haematoxylin/eosin, cresyl violet or by use of silver impregnation. Results: Gross morphological examination of the brains embedded in methylmetacrylate showed the detailed anatomy of the different parts. The staining with haematoxylin/eosin permitted to differentiate the grey matter, the different nucleus and the layers of cerebral and cerebellum cortex. The cresyl violet technique permitted to visualize the Nissl bodies and the silver impregnation revealed nerve fibers. In the fetus brain, blood vessels were very numerous in the brainstem, the cerebellum and the cerebrum. The grey matter was less organized and looser. Conclusion: This work establishes an anatomical and histological approach allowing future studies in ovine fetuses with and without brain lesions potentially caused by the bluetongue virus. [less ▲]

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