References of "2011"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailSafety of long-term treatment of HAM/TSP patients with valproic acid
Olindo, Stéphane; Belrose, Gildas; Gillet, Nicolas ULg et al

in Blood (2011), 118(24), 6306-6309

HTLV-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a neurodegenerative disease of the central nervous system induced by Human T lymphotropic virus type 1 (HTLV-1). As a potential ... [more ▼]

HTLV-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a neurodegenerative disease of the central nervous system induced by Human T lymphotropic virus type 1 (HTLV-1). As a potential therapeutic approach, we previously suggested reducing the proviral load (PVL) by modulating lysine deacetylase activity using valproic acid (VPA) and exposing virus-positive cells to the host immune response. We conducted a single-center, two-year open-label trial, with 19 HAM/TSP volunteers treated with oral VPA. PVL, CD38/HLA-DR expression and CD8+ lysis efficiency were not significantly affected by VPA. Mean scores of HAM/TSP disability did not differ between baseline and final visit. Walking Time Test (WTT) increased significantly (>20%) in 3 patients and was in keeping with minor VPA side effects (drowsiness and tremor). WTT improved rapidly after VPA discontinuation. We conclude that long term treatment with VPA is safe in HAM/TSP. [less ▲]

Detailed reference viewed: 15 (8 ULg)
See detailAurores sur les planètes géantes
Bonfond, Bertrand ULg

Scientific conference (2011, December 08)

Depuis les premières détections d'émissions aurorales par les sondes Voyager à la fin des années 70, nos connaissances des aurores de Jupiter et de Saturne ont considérablement progressé. Je présenterai ... [more ▼]

Depuis les premières détections d'émissions aurorales par les sondes Voyager à la fin des années 70, nos connaissances des aurores de Jupiter et de Saturne ont considérablement progressé. Je présenterai ici quelques uns des derniers résultats obtenus à l'aide du télescope spatial Hubble et de la sonde Cassini en orbite autour de Saturne. Ces images acquises dans le domaine ultraviolet révèlent une complexité que l'on commence seulement à appréhender. Assemblées en séquences, elles dévoilent une dynamique surprenante. Flashs, pulsations, expansions, contractions, apparitions, disparitions, fusions, séparations et mouvements relatifs de structures étendues sur des dizaines de milliers de kilomètres ou localisés sur quelques centaines de kilomètres : la diversité des comportements que nous observons est le témoignage de la richesse des processus en œuvre dans les magnétosphères de Jupiter et Saturne. Lunes exotiques, volcans et geysers colossaux, champs magnétiques gigantesques et rotations planétaires rapides sont les ingrédients de ce surprenant laboratoire de physique des plasmas. [less ▲]

Detailed reference viewed: 19 (7 ULg)
Full Text
See detailCaractérisation des coposés volatils des huiles d'olive produites dans des coopératives de la région orientale du Maroc
Tanouti, K.; Serghini-Caid, H.; Sindic, Marianne ULg et al

in 5èmes Journées Internationales d'Etude sur les Lipides - JIEL 2011 : Graisses alimentaires, Lipides marins, Nutrition et Santé (2011, December 08)

Detailed reference viewed: 19 (1 ULg)
Full Text
See detailFormation à la microtomographie
Léonard, Angélique ULg; Toye, Dominique ULg; Plougonven, Erwan ULg

Learning material (2011)

This course is a two-day presentation of the basic workings of X-ray tomography, current local applications of microtomography in the applied chemistry department, typical image analysis tools for ... [more ▼]

This course is a two-day presentation of the basic workings of X-ray tomography, current local applications of microtomography in the applied chemistry department, typical image analysis tools for extracting measurements, and a practical look at a particular piece of equipment, the Skyscan 1172 desktop microtomograph, and its software. The target audience is users of such equipment, with little to no background in X-ray physics, computer science or image analysis. [less ▲]

Detailed reference viewed: 60 (24 ULg)
Full Text
See detailLe trasformazioni della "Peripèteia"
Cigana, Lorenzo ULg

Scientific conference (2011, December 07)

An analysis of the notion of "peripèteia" in Aristotle's Poetics: is it a narratologic, formal category or an interpretative one?

Detailed reference viewed: 11 (2 ULg)
See detailDesign of reversibly disulfide core cross-linked polymer micelles
Cajot, Sébastien ULg; Schol, Daureen ULg; Danhier, F. et al

Poster (2011, December 07)

Detailed reference viewed: 31 (10 ULg)
Full Text
See detailSynthèse, mise en forme et frittage de céramiques thermoélectriques de formulation In2-xGexO3
Combe, Emmanuel ULg

Doctoral thesis (2011)

Ce travail de thèse porte sur l’étude des relations procédé, micro/nanostructures et propriétés thermoélectriques de composés oxydes de formulation In2-xGexO3. Dans ce contexte, des techniques de synthèse ... [more ▼]

Ce travail de thèse porte sur l’étude des relations procédé, micro/nanostructures et propriétés thermoélectriques de composés oxydes de formulation In2-xGexO3. Dans ce contexte, des techniques de synthèse des poudres par chimie douce (procédé citrate), de mise en forme en milieu liquide (coulage en moule poreux) et de frittage non conventionnel des céramiques (frittage micro-ondes) ont été développées. Par comparaison à des procédés d’élaboration classiques, le développement du procédé citrate a permis la préparation de microstructures homogènes permettant d’optimiser les propriétés de transport. La figure de mérite ZT des composés In2-xGexO3 atteint ainsi des valeurs supérieures à 0,3 à 1000 K. Afin de mieux contrôler la densification pendant le frittage, l’utilisation d’une technique de mise en forme par coulage en moule poreux a été expérimentée et des densités après frittage proches de la densité théorique ont pu être obtenues grâce à une mise en ordre optimisée des particules dans les composés crus. Le développement du frittage micro-ondes à ce type de matériau a par ailleurs permis d’obtenir des microstructures très fines (taille de grains inferieure à 500 nm). Un dispositif thermoélectrique (surface de 35 × 40 mm², 56 jambes) de formulations Ca3Co4O9 et In1.994Sn0.006O3 a été également réalisé. Celui-ci délivre une puissance de 480 mW pour un gradient de température de 550 K. Ces différentes études ouvrent des perspectives intéressantes dans l’élaboration de composés et de dispositifs thermoélectriques à base d’éléments oxydes présentant des performances accrues. [less ▲]

Detailed reference viewed: 83 (10 ULg)
Full Text
Peer Reviewed
See detailEffective conservation of an endangered newt species (Triturus cristatus): determinants from local to landscape scales
Denoël, Mathieu ULg; Perez, Amélie; Ficetola, Francesco

Conference (2011, December 07)

Detailed reference viewed: 49 (4 ULg)
Full Text
Peer Reviewed
See detailComment programmer un système neuronal avec un langage et une conscience ?
Dubois, Daniel ULg

in Acta Europeana Systemica (2011, December 07), 1

This communication deals with the question to know if this is possible to program a neural system with a language and a consciousness. There are several levels and categories of language, by example ... [more ▼]

This communication deals with the question to know if this is possible to program a neural system with a language and a consciousness. There are several levels and categories of language, by example, verbal and non-verbal languages, signs language, etc. There are also several levels and categories of consciousness, by example, verbal consciousness, non-verbal selfconsciousness, and absence of consciousness with the a-consciousness. By a systemic approach, we extend the role of the brain to the whole neural ectoderm, including the nervous systems, the brainstem, the brain, and the skin that is the actual envelope of the brain to the environment. This paper will demonstrate that such a neural system can be programmed, on the basis of scientific research in experimental neurosciences and in artificial intelligence, extending de facto all the possibilities of learning of classical neural networks. [less ▲]

Detailed reference viewed: 124 (5 ULg)
Full Text
Peer Reviewed
See detailIntelligence Naturelle et Intelligence Artificielle
Dubois, Daniel ULg

in Acta Europeana Systemica (2011, December 07), 1

This article presents a systemic approach to the concept of natural intelligence with the aim of creating an artificial intelligence. Thus, the natural intelligence, human and nonhuman animals, is a ... [more ▼]

This article presents a systemic approach to the concept of natural intelligence with the aim of creating an artificial intelligence. Thus, the natural intelligence, human and nonhuman animals, is a function composed of faculties to know and understand. In addition, natural intelligence is inseparable from the structure, namely the organs of the brain and body. The temptation is to equip computer systems with artificial intelligence that should have a function composed of the same faculties as those encompassed in human intelligence. The artificial intelligence must also remain inseparable from the structure, namely the organs of an artificial brain and an artificial body. As a result, the artificial robot is the ideal structure to see the emergence of a strong artificial intelligence. Note that a weak artificial intelligence is developed on computer systems by a simulation program of intelligence. In this paper, neural programmable memories will be presented and simulated [less ▲]

Detailed reference viewed: 114 (5 ULg)
Full Text
See detailEfficiently Approximating Markov Tree Bagging for High-Dimensional Density Estimation
Schnitzler, François ULg

Scientific conference (2011, December 07)

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailChanges in histone H4 acetylation during in vivo versus in vitro maturation of equine oocytes
Franciosi, Federica; Lodde, Valentina; Goudet, Ghylène et al

in Molecular Human Reproduction (2011)

Epigenetic modifications are established during gametogenesis and preimplantation embryonic development. Any disturbance of the normal natural environment during these critical phases could cause ... [more ▼]

Epigenetic modifications are established during gametogenesis and preimplantation embryonic development. Any disturbance of the normal natural environment during these critical phases could cause alterations of the epigenetic signature. Histone acetylation is an important epigenetic modification involved in the regulation of chromatin organization and gene expression. The present study was aimed to determine whether the proper establishment of post-translational histone H4 acetylation at lysine 8 (AcH4K8), 12 (AcH4K12), and 16 (AcH4K16) of equine oocytes is adversely affected during in vitro maturation when compared to in vivo matured oocytes collected from naturally cycling mares not undergoing ovarian hyperstimulation. The acetylation patterns were investigated by means of indirect immunofluorescence staining with specific antibodies directed against the acetylated lysine residues. Our results indicate that the acetylation state of H4 is dependent on the chromatin configuration in immature GV stage oocytes and it changes in a residue-specific manner along with the increase of chromatin condensation. In particular, the levels of AcH4K8 and AcH4K12 increased significantly, while AcH4K16 decreased significantly from the fibrillar to the condensed state of chromatin configuration within the GV. Moreover, during meiosis K8 and K12 were substantially deacetylated without any differences between in vivo and in vitro conditions, while K16 displayed a strong acetylation in oocytes matured in vivo, and in contrast, it was markedly deacetylated following in vitro maturation. Although the functional meaning of residue-specific acetylation during oocyte differentiation and meiotic resumption needs further investigation, our results support the hypothesis that in vitro maturation conditions can adversely affect oocyte ability to regulate the epigenetic reprogramming, critical for successful meiosis and subsequent embryonic development. [less ▲]

Detailed reference viewed: 16 (2 ULg)
Full Text
See detailSaving our soil information, making our soil map more understandable, usable and useful in the digital era: contribution of the Digital Soil Map of Wallonia Project
Legrain, Xavier ULg; Michel, Brieuc ULg; Bock, Laurent ULg et al

Scientific conference (2011, December 07)

Due to greater awareness of the necessity to preserve soil functions from human pressure on the environment, the need for soil information is increasing. Supported by the evolution of technologies these ... [more ▼]

Due to greater awareness of the necessity to preserve soil functions from human pressure on the environment, the need for soil information is increasing. Supported by the evolution of technologies these last decades, great efforts were achieved to provide up-to-date, high resolution, continuous data on soil properties. These efforts are valuable and necessary, but they are often restricted to limited surfaces. Morevover, each of these data reveals partial picture of the soil and doesn’t give an insight into their genesis, organisation and functionality. Therefore the Soil Map of Belgium remains an essential resource. On the other hand, foreign (soil) scientists frequently claim that we (the Belgium country) have a prodigious soil map and implicitly conclude we don’t need any more soil information. More questionable, many users of the now available digital soil maps think they obtained the « Holy Grail » allowing them to extract all the information they need about soil. This is clearly not the case, many currently « wanted » soil parameters being either missing, or displaying insufficient precision. But the wealthy potential of the Soil Map of Belgium in itself is not enough nor always advisedly used. Here are some of the multiple reasons to underline: (i) the map and its legend are complex and few people take/have time to (properly) learn it before use ; (ii) the great number of legend units is confusing for users, lacking tools for organising and stratifying their data ; (iii) the easygoing use (from a GIS point of view) of the legend units, due to their concatenated structure and facilitated by the split structure of the digital map’s attribute table, leads incidiously to a clearcut « symbol by symbol » use of the map, coupled with strict definition of the symbols. Hence a sharp loss of information and comprehension emerging from the whole legend unit or linked to the interpretation of the symbols ; (iv) without the undeniable expert knowledge of the generation who made the map, the current users don’t have in mind the regional nuance, the numerous implicit information lying into the legend, the concepts used during the survey and reflecting state of knowledge on soil formation and their relative importance for agricultural land-use in the 1950s ; (v) the new generation is desperatly short of practice of soil observation in the field ; (vi) a wealth of information is also being lost when the field notes, unpublished reports, minutes of meetings and draft maps are being disregarded, as well as other legacy data associated with the map (booklets, monographs, …). This presentation will show through selected examples how the Digital Soil Map of Wallonia Project contribute to overcome this situation in order to reach this ambitious but feasible objective : a better understanding and use of the Soil Map of Belgium by the maximum of people. [less ▲]

Detailed reference viewed: 25 (4 ULg)
See detailEtude des propriétés physico-chimiques et technofonctionnelles des crèmes végétales en relation avec les conditions de reconstitution
Anihouvi, Prudent Placide ULg

Doctoral thesis (2011)

In this work, an integrated approach was adopted to study vegetal creams in order to have a global understanding of their properties. This approach included: (i) the influence of fat and other ingredients ... [more ▼]

In this work, an integrated approach was adopted to study vegetal creams in order to have a global understanding of their properties. This approach included: (i) the influence of fat and other ingredients of the formulation, particularly a low molecular weight surfactant, Tween 60 (ii) and the manufacturing process implemented for their preparation. The effect of fat was investigated by adopting an original approach that consisted in studying both the thermal and structural behavior of the non-emulsified fat (NEF) and the emulsified fat (EF). This clearly demonstrated the impact of the physicochemical characteristics of fat on the physicochemical and technofunctional properties of creams. It well established that small differences in the composition of fats may have great effects on the technofunctional behavior of creams. The influence of fat on the final properties of creams was mainly marked through the crystallization and melting behaviors of fat, and through the crystalline varieties formed during maturation. The effect of temperature on the stability of creams based on the physical evolution of the fat was also highlighted. The addition of tween 60 to the formulation significantly improved the properties of particle size, rheology, stability and whipping of creams. This improvement was the result of not only synergistic effect of surfactant molecules of buttermilk and tween 60 during emulsification but also desorption of proteins from the drop surfaces and modification of crystallization of the EF. The study of the influence of the process showed that the choice of the emulsification method and operating parameters are important considerations in the reconstitution of creams. It was shown that it was possible to modulate the properties of creams by only modifying the process. [less ▲]

Detailed reference viewed: 56 (11 ULg)
Full Text
Peer Reviewed
See detailTime delays for eleven gravitationally lensed quasars revisited
Eulaers, Eva ULg; Magain, Pierre ULg

in Astronomy and Astrophysics (2011), 536

Aims. We test the robustness of published time delays for 11 lensed quasars by using two techniques to measure time shifts in their light curves. Methods. We chose to use two fundamentally different ... [more ▼]

Aims. We test the robustness of published time delays for 11 lensed quasars by using two techniques to measure time shifts in their light curves. Methods. We chose to use two fundamentally different techniques to determine time delays in gravitationally lensed quasars: a method based on fitting a numerical model and another one derived from the minimum dispersion method introduced by Pelt and collaborators. To analyse our sample in a homogeneous way and avoid bias caused by the choice of the method used, we apply both methods to 11 different lensed systems for which delays have been published: JVAS B0218+357, SBS 0909+523, RX J0911+0551, FBQS J0951+2635, HE 1104-1805, PG 1115+080, JVAS B1422+231, SBS 1520+530, CLASS B1600+434, CLASS B1608+656, and HE 2149-2745 Results. Time delays for three double lenses, JVAS B0218+357, HE 1104-1805, and CLASS B1600+434, as well as the quadruply lensed quasar CLASS B1608+656 are confirmed within the error bars. We correct the delay for SBS 1520+530. For PG 1115+080 and RX J0911+0551, the existence of a second solution on top of the published delay is revealed. The time delays in four systems, SBS 0909+523, FBQS J0951+2635, JVAS B1422+231, and HE 2149-2745 prove to be less reliable than previously claimed. Conclusions. If we wish to derive an estimate of H0 based on time delays in gravitationally lensed quasars, we need to obtain more robust light curves for most of these systems in order to achieve a higher accuracy and robustness on the time delays. [less ▲]

Detailed reference viewed: 23 (7 ULg)
See detailModeling the potential for Eurasian Lynx (Lynx lynx) return in lowland Western Europe
Bouyer, Yaëlle ULg; Poncin, Pascal ULg; Beudels-Jamar, Roseline et al

Poster (2011, December 06)

In the last forty years, tolerance of anthropic environment has allowed large carnivores to recolonize and expand their distribution in Western Europe. To assess the full potential and consequences of ... [more ▼]

In the last forty years, tolerance of anthropic environment has allowed large carnivores to recolonize and expand their distribution in Western Europe. To assess the full potential and consequences of this return, habitat use and landscape modeling are particularly useful tools that allow conservationists to come up with reliable prediction, and policy makers to anticipate management planning. The considerable power of dispersal and important space requirements of these species necessitate large-scale modeling, but it is essential to work in parallel at very fine scale, as carnivores’ impact on human societies is mostly felt at local level. Management of large carnivores must therefore be multi-scalar, with different decisions taken at multiple levels. With the return of the Eurasian Lynx (Lynx lynx) to lowland Western Europe, in regions of relatively high human densities, conservation- planning decisions must be knowledge based. Different approaches will be followed to analyze data at finer and larger scales. These include differential distribution and tolerance of lynx to fragmentation and anthropization, influence of landscape on lynx predation and the development of a conceptual model aiming at responding efficiently to conflicts with human populations. Results will permit the development of a lowland Western Europe habitat model, and to propose conservation measures adapted to the return of this emblematic carnivore. Results will permit the development of a lowland Western Europe habitat model, and to propose conservation measures adapted to the return of this emblematic carnivore. [less ▲]

Detailed reference viewed: 40 (2 ULg)
Full Text
See detailSimplified dynamic simulation
Van Cutsem, Thierry ULg; Fabozzi, Davide ULg

Conference (2011, December 06)

These are the slides of an invited presentation at the panel session "Pan European Grid Advanced Simulation and State Estimation (PEGASE)", aimed at disseminating the results of the PEGASE project funded ... [more ▼]

These are the slides of an invited presentation at the panel session "Pan European Grid Advanced Simulation and State Estimation (PEGASE)", aimed at disseminating the results of the PEGASE project funded by European Community’s 7th Framework Programme (grant agreement No. 211407) [less ▲]

Detailed reference viewed: 130 (11 ULg)
See detailNew glucose-responsive polyelectrolyte microcapsules
Alaimo, David ULg; Detrembleur, Christophe ULg; Auzély-Velty, Rachel et al

Poster (2011, December 06)

Diabetes is a disorder of glucose regulation, characterized by an accumulation of glucose in the blood. The breakdown of glucose regulation can be attributed to the pancreas’s inability to secrete insulin ... [more ▼]

Diabetes is a disorder of glucose regulation, characterized by an accumulation of glucose in the blood. The breakdown of glucose regulation can be attributed to the pancreas’s inability to secrete insulin or to the body’s inability to properly use it. The usual treatment for type 1 diabetes consists in multiple subcutaneous insulin injections, daily administered using needles, insulin pen or insulin pump. However, this method doesn’t maintain normoglycemia and can lead to complications such as limb amputation, blindness, and kidney failure. To avoid such abnormal episodes, scientists imagined smart systems which are able to regulate the glucose level by themselves. During the past decades, a large variety of micro- and nanocarriers have been developed in order to improve efficiency, availability and toxicity profiles of drugs. In this field, stimuli-responsive polymer multilayers have attracted great scientific interest because of their potential applications as controlled delivery or release systems, for chemicals and drugs. A category of stimuli-responsive materials is able to sense glucose and respond to it by a modification of their porosity, leading to a release of insulin. The objective of this work was to investigate the formation of glucose responsive hollow microcapsules (5 microns) made of polyelectrolyte copolymers. These copolymers are composed of carbohydrate-sensitive functions, such as boronic acid and diols (PVOH), known for forming reversible covalent ether bond. In presence of carbohydrates such as glucose, the ether bonds will be reversibly broken and, consequently, the porosity of the glucose particles will change. Therefore, polyelectrolyte copolymers were synthesized by control radical polymerization, i.e. reversible addition-fragmentation chain transfer (RAFT, polyboronic acid) and cobalt-mediated radical polymerization (CMRP, PVOH). Using these polyelectrolytes as polyanions and poly(allylamine) (PAH) as a polycation, we undertook the formation of layer-by-layer capsules starting with a template of CaCO3microparticles which can be dissolved with EDTA leading to the formation of hollow microcapsules. Bovin serum albumin isothiocyanate (BSA-FITC) was used to fill the CaCO3microparticles and to determine the porosity of the resulting capsules in function of the glucose concentration. The sugar-dependent porosity is investigated by following the release of encapsulated BSA-FITC by spectro-fluoroscopy. [less ▲]

Detailed reference viewed: 15 (2 ULg)
See detailAnalytical strategies for the detection of counterfeit erectile dysfunction drugs
Sacré, Pierre-Yves ULg

Doctoral thesis (2011)

Since the late eighties, when it was first mentioned, the worldwide phenomenon of pharmaceutical counterfeiting is growing. Belgian customs often encounter presumed counterfeited medical products in ... [more ▼]

Since the late eighties, when it was first mentioned, the worldwide phenomenon of pharmaceutical counterfeiting is growing. Belgian customs often encounter presumed counterfeited medical products in Belgian airports and ports because of their central position in Europe and their importance in the transit of goods. Further and deeper analyses are required to assess the counterfeit character of these goods and to provide a scientific basis for the eventual legal procedure. As reference laboratory for the federal agency for medicines and health products (FAMHP), the Scientific Institute of Public Health (IPH) frequently analyses illegal and counterfeit pharmaceutical preparations. The present research project was started with the objective of evaluating several existing methods and developing new analytical methods to detect counterfeit erectile dysfunction drugs. This thesis is focused on the analysis of illegal samples of phosphodiesterase type 5 inhibitors (PDE5-i) containing drugs because these are the most counterfeited pharmaceutical specialities in Belgium. The research was divided into a spectroscopic and a chromatographic part: Infrared based spectroscopies have already demonstrated their ability to detect counterfeit drugs. The first part of the study evaluates the capacity of each technique (mid-infrared (mid-IR), near-infrared (NIR) and Raman spectroscopy) separately and their combinations to discriminate genuine from illegal tablets. Then, the Classification And Regression Trees (CART) algorithm has been used to classify the different samples following the classification system of the Dutch National Institute for Public Health and the Environment (RIVM). The second spectroscopic approach used Raman microspectroscopy mapping to detect counterfeited Viagra®. This technique allows the detection of different compounds according to their Raman spectrum but also the study of the distribution of a selected ingredient among the core of a tablet. The chromatographic part consists of the development and validation of a new Ultra High Pressure Liquid Chromatography method coupled with a UV diode array detector (UHPLC-DAD) and compatible with mass spectrometry (MS) to detect and quantify the three authorised phosphodiesterase type 5 inhibitors (sildenafil, tadalafil and vardenafil) and five of their analogues in illegal pharmaceutical preparations. This method has been validated between +/- 5% acceptance limits using the total error approach and has been compared to the official Viagra® assay method. The ability of HPLC-UV impurity fingerprints to detect illegal samples and to predict whether a new unknown sample is genuine has also been evaluated. The developed analytical methods may be included in a general approach to detect counterfeit drugs containing PDE5-i. This generic approach may also be used to detect other types of counterfeited drugs but should therefore be adapted for each type of medicine. [less ▲]

Detailed reference viewed: 109 (7 ULg)
See detailL’édition de la Correspondance littéraire de Frédéric-Melchior Grimm
Tilkin, Françoise ULg

Scientific conference (2011, December 06)

Detailed reference viewed: 18 (6 ULg)