References of "2010"
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See detailGramaccioliite-(Y): paragenesis, chemical, structural, thermal expansion, and compressibility data on a new occurrence from Samos Island, Greece
Theye, Thomas; Hatert, Frédéric ULg; Ockenga, E. et al

in European Journal of Mineralogy (2010), 22

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See detailInfluence Lianol Solapro on sow colostrums production
Wavreille, José; Planchon, Viviane; Renaville, Robert ULg et al

in 21 Inter. Pig Vet Society Congress (2010)

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See detailAssessment of exposure to persistent organochlorine compounds in epidemiological studies on breast cancer : a literature review and perspectives for the CECILE study
Bachelet, D.; Verner, M.-A.; Guihenneuc-Jouyaux, C. et al

in Acta Clinica Belgica (2010), 65(1), 49-57

Breast cancer is the most frequent neoplastic disease in women representing 50,000 new cases each year in France. The well-established risk factors, as those related to the reproductive history, cannot ... [more ▼]

Breast cancer is the most frequent neoplastic disease in women representing 50,000 new cases each year in France. The well-established risk factors, as those related to the reproductive history, cannot account for all cases of breast cancer. Other environmental or lifestyle factors need to be explored in depth. Persistent organochlorine compounds (OCs) have attracted attention because of their endocrine disrupting properties that make them possible risk factors for breast cancer, but most epidemiological studies did not report an association between OC concentrations in blood or adipose tissue and breast cancer risk. In these studies, OC levels were measured in biological samples obtained at the time of cancer diagnosis or only a few years before. In this paper, we review the studies on dichlorodiphenyltrichloroethane (DDT) and polychlorobiphenyl (PCB) exposures in relation to breast cancer. We discuss the relevance of OC biological measurements as lifelong exposure indicators, and we describe a new method for assessing exposure to OCs in epiderniological studies. Most studies were carried out recently and reported OC concentrations that were substantially lower than those reported during the 1960s and 1970s. We make the assumption that these OC levels were not reliable indicators, as they were not measured during etiologically relevant periods in a woman's lifetime, i.e. during the prenatal period, the puberty or the period before a first full-term pregnancy, which are regarded as key periods of vulnerability of mammary gland cells to carcinogens. This may have resulted in non differential exposure misclassification and hence in the absence of an observed association between OC levels and breast cancer in most epidemiological studies. Physiologically-based pharmacokinetic (PBPK) models allow estimating persistent organic pollutant lifetime toxicokinetics profiles retrospec- tively in women, by taking into account individual differences in metabolism and key events that affect OC kinetics such as lactation and weight variations. PBPK models will be applied to the participants of a large French population-based case-control study including 1080 cases and 1055 controls. Exposure misclassification could have prevented from observing an association between exposure to OCs and breast cancer risk. PBPK models could be used as a novel way of assessing exposure to OCs and to investigate the impact of internal exposure at different time windows on breast cancer incidence. [less ▲]

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See detailTreatment of osteoporosis: recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivity.
Musette, P.; Brandi, M. L.; Cacoub, P. et al

in Osteoporosis International (2010), 21

Cutaneous adverse reactions are reported for many treatments including antiosteoporotic agents. This position paper includes an algorithm for their recognition. With early recognition and proper ... [more ▼]

Cutaneous adverse reactions are reported for many treatments including antiosteoporotic agents. This position paper includes an algorithm for their recognition. With early recognition and proper management, including immediate and permanent withdrawal of the culprit agent, accompanied by hospitalization, rehydration, and systemic corticosteroids, if necessary, the prognosis is good. INTRODUCTION: Cutaneous adverse reactions are reported for many therapeutic agents and observed in between 0% and 8% of treated patients depending on the drug. The antiosteoporotic agents are reputed to be safe in terms of cutaneous effects; however, there have been a number of case reports of cutaneous adverse reactions, which merit consideration. This was the subject of a Working Group meeting of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis in April 2009, to focus on the impact of cutaneous adverse reactions and drug-induced hypersensitivity in the management of postmenopausal osteoporosis. We prepared this position paper following these discussions, and include an algorithm for their recognition. METHODS: We reviewed cutaneous adverse reactions observed with antiosteoporotic agents, including information from case reports, regulatory documents, and pharmacovigilance. RESULTS: The cutaneous adverse reactions range from benign reactions including exanthematous or maculopapular eruption (drug rash), photosensitivity, and urticaria to the severe and potentially life-threatening reactions, angioedema, drug rash with eosinophilia and systemic symptoms (DRESS), Stevens Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Review of available evidence shows that cutaneous adverse reactions occur with all commonly used antiosteoporotic agents. Notably, there are reports of SJS and TEN for bisphosphonates, and of DRESS and TEN for strontium ranelate. These severe reactions remain very rare (<1 in 10,000 cases). CONCLUSION: With early recognition and proper management, including immediate and permanent withdrawal of the culprit agent, accompanied by hospitalization and rehydration and systemic corticosteroids if necessary, the prognosis is good. [less ▲]

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See detailTowards a European Consumer Construction Law?
Kohl, Benoît ULg

in International Construction Law Review (2010), 27(2), 211-241

If European action is necessary for the unification of liabilities in the European construction industry, it may be wiser to commence Community action by focusing on the specific interests of private ... [more ▼]

If European action is necessary for the unification of liabilities in the European construction industry, it may be wiser to commence Community action by focusing on the specific interests of private consumers rather than seeking to develop a European Code covering all aspects of private construction law. The aim of this paper is to explain my preference for this focused approach and, by comparing the current state of the Law in England and in France, to establish the points of convergence that could constitute the basis of European intervention in that field. I will specifically deal with the differing approaches taken by both countries to identical social problems. In conclusion, I suggest a dual approach to harmonisation in the housing construction sector. After having fixed, in a European legislative instrument, the objectives of the substantive minimal protection that every consumer should be able to enjoy across Europe, Member States should be encouraged to provide self-regulatory bodies – or potentially even one international self-regulatory body at the European level - for the attainment of these objectives. This “co-regulation” mechanism, applied to my comparative study of French and English consumer protection in the housing sector, suggests that very few modifications at a national level in both countries would be required to meet the suggested harmonisation. [less ▲]

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See detailAngiogenic fast-growing melanomas and their micrometastases.
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Paquet, Philippe ULg et al

in European Journal of Dermatology (2010), 20(3), 302-7

Malignant melanoma (MM), particularly its fast-growing type, is prone to interstitial, intravascular and extravascular migratory metastases. There is no information linking their growth fraction, the ... [more ▼]

Malignant melanoma (MM), particularly its fast-growing type, is prone to interstitial, intravascular and extravascular migratory metastases. There is no information linking their growth fraction, the configuration of the MM advancing edge, the extent in vascularity and the propensity to metastatic progression. The objective of this study was to determine the growth fraction, the size of vascularity and the contours of the progression border of 32 fast-growing MM with regard to the presence or absence of a micrometastatic spread inside the skin and overt metastases in the sentinel lymph nodes. In vivo high resolution colorimetry was performed as a clinical estimate of MM vascularity. Euclidean geometry and fractal analysis were used on immunohistochemical sections. The relative microvasculature profile area beneath MM, and the fractal dimension D of the MM frontline were assessed. The MIB/Ki-67 index was determined in MM cells. Value a* of colorimetry was similarly increased in the presence or absence of micro-metastases. No difference in growth fraction was revealed between these neoplasms. Correlations were found between vascularity and angiotropism, and between the micrometastatic process and the sentinel lymph node involvement. By contrast, no correlation was shown between vascularity and the fractal D dimension of the MM advancing edge. In sum, this study establishes a link between the extent of MM growth fraction, vascularity and the presence of dermal and nodal micrometastases in fast-growing MM. [less ▲]

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See detailOutils de dramatisation chez Phylarque
Vanhaegendoren, Koen ULg

in Dialogues d'Histoire Ancienne [DHA] (2010), Suppl. 4.2

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See detailLes enjeux de la conjoncture 1919-1921 en Allemagne (Plaidoyer pour le dépoussierage de nos bibliothèques)
Cavazzini, Andrea ULg; Rampazzo Bazzan, Marco

in Cahiers du GRM (2010), I

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See detailMicrowave-assisted transformations of carbohydrates
Richel, Aurore ULg

Report (2010)

This reports deals with the involvment of microwaves for the conversion of renewable feedstocks, and in particlar for the tranfsormation of monosaccharides and cellulose into high added value materials.

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See detailL'astronomie dans le monde
Manfroid, Jean ULg

Article for general public (2010)

Galaxie cannibale; Archéologie cosmique; Trumpler 14; Etoile vampire; Trou noir errant; Micro-quasar gamma; Métaux intergalactiques; V838 Mon; Supernova particulière; Titan; Mars; Vie martienne ... [more ▼]

Galaxie cannibale; Archéologie cosmique; Trumpler 14; Etoile vampire; Trou noir errant; Micro-quasar gamma; Métaux intergalactiques; V838 Mon; Supernova particulière; Titan; Mars; Vie martienne; Variations des étoiles semblables au Soleil; GJ758B [less ▲]

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See detailHomme de lettres, écrivain, auteur. Déclinaison sociale d'une fonction symbolique
Durand, Pascal ULg

in Luneau, Marie-Pier; Vincent, Josée (Eds.) La Fabrication de l'Auteur (2010)

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See detailThe alpha-fetoprotein knock-out mouse model suggests that parental behavior is sexually differentiated under the influence of prenatal estradiol.
Keller, Matthieu; Pawluski, Jodi ULg; Brock, Olivier ULg et al

in Hormones & Behavior (2010)

In rodent species, sexual differentiation of the brain for many reproductive processes depends largely on estradiol. This was recently confirmed again by using the α-fetoprotein knockout (AFP-KO) mouse ... [more ▼]

In rodent species, sexual differentiation of the brain for many reproductive processes depends largely on estradiol. This was recently confirmed again by using the α-fetoprotein knockout (AFP-KO) mouse model, which lacks the protective actions of α-fetoprotein against maternal estradiol and as a result represents a good model to determine the contribution of prenatal estradiol to the sexual differentiation of the brain and behavior. In the present study, we determined whether parental responses are differentiated prenatally under the influence of estradiol. It was found that AFP-KO females showed longer latencies to retrieve pups to the nest and also exhibited lower levels of crouching over the pups in the nest in comparison to WT females. Thus our results suggest that prenatal estradiol defeminizes the parental brain in mice. [less ▲]

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See detailUsefulness and limitation of dobutamine stress echocardiography to predict acute response to cardiac resynchronization therapy.
Sénéchal, Marie; Lancellotti, Patrizio ULg; Garceau, P. et al

in Echocardiography (2010), 27(1), 50-57

Background: It has been hypothesized that a long-term response to cardiac resynchronization therapy (CRT) could correlate with myocardial viability in patients with left ventricular (LV) dysfunction ... [more ▼]

Background: It has been hypothesized that a long-term response to cardiac resynchronization therapy (CRT) could correlate with myocardial viability in patients with left ventricular (LV) dysfunction. Contractile reserve and viability in the region of the pacing lead have not been investigated in regard to acute response after CRT. Methods: Fifty-one consecutive patients with advanced heart failure, LV ejection fraction ≤ 35%, QRS duration > 120 ms, and intraventricular asynchronism ≥ 50 ms were prospectively included. The week before CRT implantation, the presence of viability was evaluated using dobutamine stress echocardiography. Acute responders were defined as a ≥15% increase in LV stroke volume. Results: The average of viable segments was 5.8 ± 1.9 in responders and 3.9 ± 3 in nonresponders (P = 0.03). Viability in the region of the pacing lead had an excellent sensitivity (96%), but a low specificity (56%) to predict acute response to CRT. Mitral regurgitation (MR) was reduced in 21 patients (84%) with acute response. The presence of MR was a poor predictor of response (sensibility 93% and specificity 17%). However, combining the presence of MR and viability in the region of the pacing lead yields a sensibility (89%) and a specificity (70%) to predict acute response to CRT. Conclusion: Myocardial viability is an important factor influencing acute hemodynamic response to CRT. In acute responders, significant MR reduction is frequent. The combined presence of MR and viability in the region of the pacing lead predicts acute response to CRT with the best accuracy. [less ▲]

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See detailFamilles monoparentales: le passage de l'adolescence à l'absence d'un père
Malchair, Alain ULg

in Acta Psychiatrica Belgica (2010), 110(3), 36-42

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See detailLa vitrification et l’utilisation de concentrations élevées en cryoprotecteurs : ceci justifie-t-il la préférence pour la congélation lente ?
Vanderzwalmen, Pierre ULg; Zech, Nicolas; Lejeune, Bernard et al

in Gynécologie Obstétrique & Fertilité (2010), 38(9), 536-40

The use of high levels of cryoprotectants (CPs) in solutions applied to vitrify oocytes or embryos is an argument to still prefer slow freezing procedure. Is it a justified argument? Out of three studies ... [more ▼]

The use of high levels of cryoprotectants (CPs) in solutions applied to vitrify oocytes or embryos is an argument to still prefer slow freezing procedure. Is it a justified argument? Out of three studies using mice zygotes we may assume that (i) the intracellular concentration of CPs is far lower than the one in the vitrification solutions, (ii) the intracellular concentration of CPs in the vitrified zygote is in contrary to the common beliefs even lower than the one observed after a slow freezing procedure, (iii) survival after slow freezing reflects the presence of an intracellular vitrified state in these cells. [less ▲]

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See detailCentralisation et décentralisation en droit wallon de l'urbanisme
Pâques, Michel ULg

in Liber amicorum Robert Andersen (2010)

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See detailExhaled nitric oxide thresholds associated with a sputum eosinophil count >=3% in a cohort of unselected patients with asthma.
Schleich, FLorence ULg; Seidel, Laurence ULg; Sele, Jocelyne ULg et al

in Thorax (2010), 65(12), 1039-1044

Background It has been claimed that exhaled nitric oxide (FeNO) could be regarded as a surrogate marker for sputum eosinophil count in patients with asthma. However, the FeNO threshold value that ... [more ▼]

Background It has been claimed that exhaled nitric oxide (FeNO) could be regarded as a surrogate marker for sputum eosinophil count in patients with asthma. However, the FeNO threshold value that identifies a sputum eosinophil count >/=3% in an unselected population of patients with asthma has been poorly studied. Methods This retrospective study was conducted in 295 patients with asthma aged 15-84 years recruited from the asthma clinic of University Hospital of Liege. Receiver-operating characteristic (ROC) curve and logistic regression analysis were used to assess the relationship between sputum eosinophil count and FeNO, taking into account covariates such as inhaled corticosteroids (ICS), smoking, atopy, age and sex. Results Derived from the ROC curve, FeNO >/=41 ppb gave 65% sensitivity and 79% specificity (AUC=0.777, p=0.0001) for identifying a sputum eosinophil count >/=3%. Using logistic regression analysis, a threshold of 42 ppb was found to discriminate between eosinophilic and non-eosinophilic asthma (p<0.0001). Patients receiving high doses of ICS (>/=1000 mug beclometasone) had a significantly lower FeNO threshold (27 ppb) than the rest of the group (48 ppb, p<0.05). Atopy also significantly altered the threshold (49 ppb for atopic vs 30 ppb for non-atopic patients, p<0.05) and there was a trend for a lower threshold in smokers (27 ppb) compared with non-smokers (46 ppb, p=0.066). Age and sex did not affect the relationship between FeNO and sputum eosinophilia. When combining all variables into the logistic model, FeNO (p<0.0001), high-dose ICS (p<0.05) and smoking (p<0.05) were independent predictors of sputum eosinophilia, while there was a trend for atopy (p=0.086). Conclusion FeNO is able to identify a sputum eosinophil count >/=3% with reasonable accuracy and thresholds which vary according to dose of ICS, smoking and atopy. [less ▲]

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See detailLa vignette thérapeutiqu de l'étudiant Diagnostic différentiel étiologique des oedmes
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2010), 65(11), 655-661

Oedema is a frequent disorder and the easily detectable consequence of an increase of fluid located in the interstitial tissue. It could be localized or generalized and related either to a primary ... [more ▼]

Oedema is a frequent disorder and the easily detectable consequence of an increase of fluid located in the interstitial tissue. It could be localized or generalized and related either to a primary disturbance of hemodynamics at the capillary level, due to a modification of the Starling’s law components with secondary water and saline retention, or to a primary retention of salt and water linked to a kidney abnormality. Generalized forms are pitting oedema, most often painless, white, bilateral and symmetric, distributed at the lower part of the body (localisation according to the gravitation law). They are different in their characteristics from localized oedema or lymphoedema which are tough. We propose a diagnostic approach based on medical history, clinical examination which allows a confident medical diagnosis and so an adapted therapy. [less ▲]

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See detailThe protein Nod2: an innate receptor more complex than previously assumed.
Lecat, Aurore ULg; Piette, Jacques ULg; Legrand-Poels, Sylvie ULg

in Biochemical Pharmacology (2010), 80(12), 2021-31

For almost 10 years, Nod2 has been known as a cytosolic innate receptor able to sense peptidoglycan from Gram-positive and -negative bacteria and to trigger RIP2- and NF-kappaB-mediated pro-inflammatory ... [more ▼]

For almost 10 years, Nod2 has been known as a cytosolic innate receptor able to sense peptidoglycan from Gram-positive and -negative bacteria and to trigger RIP2- and NF-kappaB-mediated pro-inflammatory and antibacterial response. Mutations in the gene encoding Nod2 in humans have been associated with Crohn's disease (CD). Mechanisms by which Nod2 variants can lead to CD development are still under investigation. The most admitted hypothesis suggests that the impaired function of Nod2 variants in intestinal epithelial and phagocytic cells results in deficiencies in epithelial-barrier function which subsequently lead to increased bacterial invasion and inflammation at intestinal sites. Very recent results have just reinforced this hypothesis by demonstrating that Nod2 wild-type (unlike Nod2 variants) could mediate autophagy, allowing an efficient bacterial clearance and adaptative immune response. Other recent data have attributed new roles to Nod2. Indeed, Nod2 has been shown to activate antiviral innate immune responses involving IRF3-dependent IFN-beta production after viral ssRNA recognition through a RIP2-independent mechanism requiring the mitochondrial adaptor protein MAVS. Recently, Nod2 has been also shown to be exquisitely tuned to detect mycobacterial infections and mount a protective immunity against these pathogens. [less ▲]

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