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See detailVaccinations in patients with immune-mediated inflammatory diseases.
Rahier, Jean-Francois; Moutschen, Michel ULg; Van Gompel, Alfons et al

in Rheumatology (2010), 49(10), 1815-27

Patients with immune-mediated inflammatory diseases (IMID) such as RA, IBD or psoriasis, are at increased risk of infection, partially because of the disease itself, but mostly because of treatment with ... [more ▼]

Patients with immune-mediated inflammatory diseases (IMID) such as RA, IBD or psoriasis, are at increased risk of infection, partially because of the disease itself, but mostly because of treatment with immunomodulatory or immunosuppressive drugs. In spite of their elevated risk for vaccine-preventable disease, vaccination coverage in IMID patients is surprisingly low. This review summarizes current literature data on vaccine safety and efficacy in IMID patients treated with immunosuppressive or immunomodulatory drugs and formulates best-practice recommendations on vaccination in this population. Especially in the current era of biological therapies, including TNF-blocking agents, special consideration should be given to vaccination strategies in IMID patients. Clinical evidence indicates that immunization of IMID patients does not increase clinical or laboratory parameters of disease activity. Live vaccines are contraindicated in immunocompromized individuals, but non-live vaccines can safely be given. Although the reduced quality of the immune response in patients under immunotherapy may have a negative impact on vaccination efficacy in this population, adequate humoral response to vaccination in IMID patients has been demonstrated for hepatitis B, influenza and pneumococcal vaccination. Vaccination status is best checked and updated before the start of immunomodulatory therapy: live vaccines are not contraindicated at that time and inactivated vaccines elicit an optimal immune response in immunocompetent individuals. [less ▲]

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See detailWhat’s in a name: Social vulnerabilities and the refugee controversy in the wake of Hurricane Katrina
Gemenne, François ULg

in Afifi, Tamer; Jäger, Jill (Eds.) Environment, Forced Migration and Social Vulnerability (2010)

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See detailLe droit européen de la concurrence au banc des accusés
Petit, Nicolas ULg

in Revue de la Faculté de Droit de l'Université de Liège (2010), (2),

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See detailLate Holocene environmental changes inferred from diatom, chironomid, and pollen assemblages in an Andean lake in Central Chile, Lake Laja (36°S)
Urrutia, Roberto; Araneda, Alberto; Torres, Laura et al

in Hydrobiologia (2010), 648

A sediment core encompassing the last 2000 years was extracted from Lake Laja, Chile, (36°54′S, 71°05′W) using an Uwitec drilling platform. The sediment was subsampled for loss on ignition, nutrients ... [more ▼]

A sediment core encompassing the last 2000 years was extracted from Lake Laja, Chile, (36°54′S, 71°05′W) using an Uwitec drilling platform. The sediment was subsampled for loss on ignition, nutrients, biogenic silica, and biological proxies (diatoms, chironomids, pollen). The sedimentary profile was characterized by several coarse volcanic layers. Loss on ignition, nutrients, and biogenic silica showed an increasing trend that suggests a recent shift to a higher trophic status. Diatom assemblages also suggested higher nutrient content with increased abundances of Aulacoseira granulata, A. distans, and Asterionella formosa. At the same time, a marked change in the benthic and facultative planktonic taxa may be associated with cooling. This period of change coincides with the European Little Ice Age (LIA). The chironomid profile showed four key zones distinguished largely by changes in the abundance of Tanytarsini, Parachironomus, and Macropelopia. Like diatoms, chironomids also seemed to reflect a shift to higher trophic conditions in the upper part reflected by increasing abundance of taxa such as Tribelos/Phaenopsectra, Cricotopus/Orthocladius, and Ablabesmyia. The most striking feature in the chironomid assemblage is the abundance of Podonominae, Parapsectrocladius, and Limnophyes/Compterosmittia, which could be associated with a cold-dry period between 1500 and 1900 AD in Lake Laja (the period of the European LIA). Pollen assemblages indicated fluctuations in humidity through changes in Nothofagus dombeyi-type, Poaceae, and Ephedra, and we inferred a strong human impact over the last 100 years from the appearance of Plantago and increased levels of Poaceae and Asteraceae subf. Cichorioidae. Finally, the three proxies showed the occurrence of a cold-dry event in Lake Laja (~1550–1900 AD), which roughly coincides with the European LIA. However the data from this research, does not prove neither rejects the existence of the occurrence of the MWP in the central Andes. [less ▲]

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See detailOperational Risk and Reputation in the Financial Industry
Gillet, Roland; Hübner, Georges ULg; Plunus, Séverine ULg

in Journal of Banking and Finance (2010), 34

By examining stock market reactions to the announcement of operational losses by financial companies, this paper attempts to disentangle operational losses from reputational damage. Our analysis deals ... [more ▼]

By examining stock market reactions to the announcement of operational losses by financial companies, this paper attempts to disentangle operational losses from reputational damage. Our analysis deals with 154 events coming from the FIRST database of OpVantage. Events occurred between 1990 and 2004 in companies belonging to the financial sector and that are listed on the major European and US Stock Exchanges. Results show significant, negative abnormal returns at the announcement date of the loss, along with an increase in the volumes of trade. In cases of internal fraud, the loss in market value is greater that the operational loss amount announced, which is interpreted as a sign of reputational damage. Negative impact is proportionally greater when the loss amount represents a larger share in the company’s net profit. [less ▲]

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See detailComponent-resolved diagnosis in peanut and hazelnut allergy.
Gadisseur, Romy ULg; Chapelle, Jean-Paul ULg; Cavalier, Etienne ULg et al

in Allergy (2010), 65(Suppl.92), 106

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See detailClaude Lévi-Strauss. Notice nécrologique pour L'Année sartrienne
Cormann, Grégory ULg

in Cormann, Grégory (Ed.) L'Année sartrienne, n° 24 (2010)

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See detailCost-effectiveness of strontium ranelate versus risedronate in the treatment of postmenopausal osteoporotic women aged over 75 years.
Hiligsmann, Mickaël ULg; Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Bone (2010), 46(2), 440-6

OBJECTIVE: To estimate the cost-effectiveness of strontium ranelate in the treatment of postmenopausal osteoporotic women aged over 75 years. MATERIALS AND METHODS: A validated Markov microsimulation ... [more ▼]

OBJECTIVE: To estimate the cost-effectiveness of strontium ranelate in the treatment of postmenopausal osteoporotic women aged over 75 years. MATERIALS AND METHODS: A validated Markov microsimulation model with a Belgian payer's perspective estimated the cost per quality-adjusted life-year (QALY) of a 3-year strontium ranelate treatment compared with no treatment and with the bisphosphonate risedronate. Data on the effect of both treatments on fracture risk were taken from the Cochrane Database of Systematic Reviews. Analyses were performed for postmenopausal women aged 75 and 80 years, either with a diagnosis of osteoporosis (i.e. bone mineral density T-score </=-2.5 SD) or with prevalent vertebral fractures (PVF). Parameter uncertainty was evaluated using both one-way and probabilistic sensitivity analyses. RESULTS: Strontium ranelate was dominant (i.e. more effective and less costly) versus risedronate for women with osteoporosis aged over 75 years and for women with PVF aged 80 years. The cost per QALY gained of strontium ranelate compared with risedronate at 75 years of age was euro11,435 for women with PVF. When compared with no treatment, the costs per QALY gained of strontium ranelate were euro15,588 and euro7,708 at 75 and 80 years of age for women with osteoporosis; the equivalent values were euro16,518 and euro6,015 for women with PVF. Probabilistic sensitivity analyses showed that strontium ranelate was generally more cost-effective than risedronate, in the range of 60% in all cases. CONCLUSION: The results of this study suggest that strontium ranelate is a cost-effective strategy, in a Belgian setting, for the treatment of postmenopausal osteoporotic women aged over 75 years. [less ▲]

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See detailAn Extended Shallow-water-like Model Applied to Flows in Environmental and Civil Engineering
Kerger, François ULg; Dewals, Benjamin ULg; Erpicum, Sébastien ULg et al

in Hirsch, Gerhard; Kappel, Bernd (Eds.) Hydraulic Engineering: Structural Applications, Numerical Modeling and Environmental Impacts (2010)

Objective of this text is to rigorously develop a unified mathematical model to simulate a wide range of environmental flows. Particular emphasis is placed on flows relevant in civil and environmental ... [more ▼]

Objective of this text is to rigorously develop a unified mathematical model to simulate a wide range of environmental flows. Particular emphasis is placed on flows relevant in civil and environmental engineering. [less ▲]

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See detailQingheiite-(Fe2+), Na2Fe2+MgAl(PO4)3, a new phosphate mineral from the Sebastião Cristino pegmatite, Minas Gerais, Brazil
Hatert, Frédéric ULg; Baijot, Maxime ULg; Philippo, Simon et al

in European Journal of Mineralogy (2010), 22

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See detailMesure du volume de fin d'expiration (VFE) en cours de ventilation contrôlée après chirurgie cardiaque
MARCHAL, Vanessa; SOTTIAUX, Thierry; PUJOL, B et al

in Réanimation (2010), 19(Suppl 1), 180325

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See detailSimulation of the formation of methanol from CO2 and H2, in electrocatalytic plasma chemical reactor
Machrafi, Hatim ULg; Cavadias, Simeon; Amouroux, Jacques

(2010)

In order to reduce atmospheric pollution by CO2 (by transport and industrial applications), CO2 can be used as a source, instead of stocking it as a product. The case considered is the reaction between ... [more ▼]

In order to reduce atmospheric pollution by CO2 (by transport and industrial applications), CO2 can be used as a source, instead of stocking it as a product. The case considered is the reaction between CO2 and H2 producing methanol: The reaction for the formation of methanol: CO2 + 3H2  CH3OH + H2O is strongly exothermique with an activation barrier needed to be surpassed and proceeds at high pressure and temperature with the use of a catalyst. The use of a non-thermal plasma namely a Dielectric Barrier Discharge (DBD) can generate energetic electrons which can initiate, excitation reactions (vibrational, electronic), dissociation, formation of radicals and ionization. Thus the activation of reactants (CO2 and H2) by the plasma can dramatically enhance the conversion of CO2. The aim of this work is to simulate this reaction associating electrical discharges and heterogeneous catalysis. The first step of the simulation in this work presents a 1D model in Matlab (Poisson equation, conservation of electrons and ions), obtaining an average electron and ion density. This electron density is then introduced in a gas phase kinetic model for the vibrational excitation and dissociation of H2/CO2 via electron collisions in the discharge region. The adsorption of radicals, produced in the gas phase, in the catalyst, is simulated using the commercial code COMSOL. The parameters studied in this work are the input power of the electrical discharge and the temperature of the catalyst on the conversion rate of CO2. [less ▲]

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See detailIII-V Devices for Advanced CMOS
Waldron, Niamh; Nguyen, Ngoc Duy ULg; Lin, Dennis et al

in 217th ECS Meeting (2010)

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See detailCombined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female Beagle dogs
Noël, Stéphanie; Cambier, Carole; Baert, Kris et al

in Veterinary Journal (2010)

This study investigated the differences in pharmacokinetic, urodynamic and haemodynamic parameters in female Beagle dogs in which blood sampling and urethral pressure profiles were performed over 24 h ... [more ▼]

This study investigated the differences in pharmacokinetic, urodynamic and haemodynamic parameters in female Beagle dogs in which blood sampling and urethral pressure profiles were performed over 24 h periods, after single or three times daily (T0-T6h-T12h) administration of phenylpropanolamine (PPA). Maximal concentration (Cmax) was reached 2 h after PPA administration (Tmax). The half-life lasted 4 h and, because of bioaccumulation, three times daily administration induced an increase in Cmax. Compared to the control group, a significant increase in urethral resistance was observed at Tmax after 1 week of once daily administrations. After one week of administering PPA every 6 h during the daytime, but not during the night, and despite higher plasma concentrations, the urethral resistance did not increase at any time, compared to the control group. The increase in mean arterial pressure values was compensated by a decreased heart rate. The clinical efficacy of the temporary increase in urethral resistance following single daily administration of PPA in dogs suffering from urethral sphincter mechanism incompetence (USMI) needs to be further investigated in a randomised clinical trial. [less ▲]

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See detailMotivational mechanisms at the origin of control task violations : An analytical case study in the pharmaceutical industry
Nyssen, Anne-Sophie ULg; Cote, Virginie

in Ergonomics (2010), 53(9), 1076-1084

The introduction of rules and procedures to guide front-line operators’ behaviour and to decrease the frequency of errors is a growing safety strategy in complex, risk systems. It is thought to be a ... [more ▼]

The introduction of rules and procedures to guide front-line operators’ behaviour and to decrease the frequency of errors is a growing safety strategy in complex, risk systems. It is thought to be a useful way of controlling and standardising human practices and of increasing safety and quality. However, merely developing procedures does not ensure that they are followed. In this study, observation was used to collect information on procedural violations in a pharmaceutical company. Interviews were conducted with the operators and the prescriptors to better understand how and why these violations were occurring. Results showed that a small number of procedures were breached by the majority of operators and that the rules which were violated were the ones associated with a perception of minimum risk. Results suggest the rationality of operators is a response to cognitive and social influences which must be taken into account when designing procedures. [less ▲]

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