References of "2010"
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See detailEvaluation et proposition de révision du deuxième Programme de Gestion Durable de l'Azote en agriculture en Région wallonne (Belgique)
Vandenberghe, Christophe ULg; Benoit, Jérémie ULg; Deneufbourg, Mathieu ULg et al

in Marcoen, Jean Marie; Vandenberghe, Christophe (Eds.) Actes de l'Atelier "Nitrate - Eau" 2 au 5 juin 2009. Peyresq, France (2010)

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See detailBrain plasticity related to the consolidation of motor sequence learning and motor adaptation
Debas, K.; Carrier, J.; Orban, Patricia ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2010), 107(41), 17839-44

This study aimed to investigate, through functional MRI (fMRI), the neuronal substrates associated with the consolidation process of two motor skills: motor sequence learning (MSL) and motor adaptation ... [more ▼]

This study aimed to investigate, through functional MRI (fMRI), the neuronal substrates associated with the consolidation process of two motor skills: motor sequence learning (MSL) and motor adaptation (MA). Four groups of young healthy individuals were assigned to either (i) a night/sleep condition, in which they were scanned while practicing a finger sequence learning task or an eight-target adaptation pointing task in the evening (test) and were scanned again 12 h later in the morning (retest) or (ii) a day/awake condition, in which they were scanned on the MSL or the MA tasks in the morning and were rescanned 12 h later in the evening. As expected and consistent with the behavioral results, the functional data revealed increased test-retest changes of activity in the striatum for the night/sleep group compared with the day/awake group in the MSL task. By contrast, the results of the MA task did not show any difference in test-retest activity between the night/sleep and day/awake groups. When the two MA task groups were combined, however, increased test-retest activity was found in lobule VI of the cerebellar cortex. Together, these findings highlight the presence of both functional and structural dissociations reflecting the off-line consolidation processes of MSL and MA. They suggest that MSL consolidation is sleep dependent and reflected by a differential increase of neural activity within the corticostriatal system, whereas MA consolidation necessitates either a period of daytime or sleep and is associated with increased neuronal activity within the corticocerebellar system. [less ▲]

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See detailQuelques histoires du japonisme
Bawin, Julie ULg

in La Lettre des Académies (2010), 20

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See detailMetalub – A Slab Method software for the numerical simulation of mixed lubrication regime. Application to cold rolling
Carretta, Yves ULg; Stephany, Antoine; Legrand, Nicolas et al

in ICTMP 2010 - International Conference on Tribology in Manufacturing processes (2010)

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See detailMatériaux composites
Courard, Luc ULg

Learning material (2010)

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See detailKnock-down of the COX3 and COX17 gene expression of cytochrome c oxidase in the unicellular green alga Chlamydomonas reinhardtii.
Remacle, Claire ULg; Coosemans, Nadine ULg; Jans, Frédéric ULg et al

in Plant Molecular Biology (2010), 74(3), 223-2363

The COX3 gene encodes a core subunit of mitochondrial cytochrome c oxidase (complex IV) whereas the COX17 gene encodes a chaperone delivering copper to the enzyme. Mutants of these two genes were isolated ... [more ▼]

The COX3 gene encodes a core subunit of mitochondrial cytochrome c oxidase (complex IV) whereas the COX17 gene encodes a chaperone delivering copper to the enzyme. Mutants of these two genes were isolated by RNA interference in the microalga Chlamydomonas. The COX3 mRNA was completely lacking in the cox3-RNAi mutant and no activity and assembly of complex IV were detected. The cox17-RNAi mutant presented a reduced level of COX17 mRNA, a reduced activity of the cytochrome c oxidase but no modification of its amount. The cox3-RNAi mutant had only 40% of the wild-type rate of dark respiration which was cyanide-insensitive. The mutant presented a 60% decrease of H(2)O(2) production in the dark compared to wild type, which probably accounts for a reduced electron leakage by respiratory complexes III and IV. In contrast, the cox17-RNAi mutant showed no modification of respiration and of H(2)O(2) production in the dark but a two to threefold increase of H(2)O(2) in the light compared to wild type and the cox3-RNAi mutant. The cox17-RNAi mutant was more sensitive to cadmium than the wild-type and cox3-RNAi strains. This suggested that besides its role in complex IV assembly, Cox17 could have additional functions in the cell such as metal detoxification or Reactive Oxygen Species protection or signaling. Concerning Cox3, its role in Chlamydomonas complex IV is similar to that of other eukaryotes although this subunit is encoded in the nuclear genome in the alga contrary to the situation found in all other organisms. [less ▲]

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See detailcompte rendu de : Florence DUPONT et Emmanuelle VALETTE-CAGNAC Façons de parler grec à Rome
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (2010), 69(3), 884-885

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See detailReanalysis of death risk in long-term follow-up in infliximab patients versus controls
Fidder, H.; Van Steen, Kristel ULg; Van Assche, G. et al

in Gut (2010), 59

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See detailDual approach for an accurate estimation of pull-in voltage
Rochus, Véronique ULg; Lemaire, Etienne ULg; Geuzaine, Christophe ULg

in Proceedings of the IVth European Conference on Computational Mechanics (ECCM 2010) (2010)

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See detailIntestinal mucosal expression of matrix metalloproteinase and ADAM genes in patients with inflammatory bowel disease and the impact of infliximab therapy
Arijs, Ingrid; Quintens, R.; Lemaire, K. et al

in Gastroenterology (2010), 138(5), 677

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See detailImmortal time bias and infliximab-related mortality and malignancy incidence
Fidder, H.; Van Steen, Kristel ULg; Van Assche, G. et al

in Gut (2010), 59

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See detailExhaled nitric oxide thresholds associated with a sputum eosinophil count >=3% in a cohort of unselected patients with asthma.
Schleich, FLorence ULg; Seidel, Laurence ULg; Sele, Jocelyne ULg et al

in Thorax (2010), 65(12), 1039-1044

Background It has been claimed that exhaled nitric oxide (FeNO) could be regarded as a surrogate marker for sputum eosinophil count in patients with asthma. However, the FeNO threshold value that ... [more ▼]

Background It has been claimed that exhaled nitric oxide (FeNO) could be regarded as a surrogate marker for sputum eosinophil count in patients with asthma. However, the FeNO threshold value that identifies a sputum eosinophil count >/=3% in an unselected population of patients with asthma has been poorly studied. Methods This retrospective study was conducted in 295 patients with asthma aged 15-84 years recruited from the asthma clinic of University Hospital of Liege. Receiver-operating characteristic (ROC) curve and logistic regression analysis were used to assess the relationship between sputum eosinophil count and FeNO, taking into account covariates such as inhaled corticosteroids (ICS), smoking, atopy, age and sex. Results Derived from the ROC curve, FeNO >/=41 ppb gave 65% sensitivity and 79% specificity (AUC=0.777, p=0.0001) for identifying a sputum eosinophil count >/=3%. Using logistic regression analysis, a threshold of 42 ppb was found to discriminate between eosinophilic and non-eosinophilic asthma (p<0.0001). Patients receiving high doses of ICS (>/=1000 mug beclometasone) had a significantly lower FeNO threshold (27 ppb) than the rest of the group (48 ppb, p<0.05). Atopy also significantly altered the threshold (49 ppb for atopic vs 30 ppb for non-atopic patients, p<0.05) and there was a trend for a lower threshold in smokers (27 ppb) compared with non-smokers (46 ppb, p=0.066). Age and sex did not affect the relationship between FeNO and sputum eosinophilia. When combining all variables into the logistic model, FeNO (p<0.0001), high-dose ICS (p<0.05) and smoking (p<0.05) were independent predictors of sputum eosinophilia, while there was a trend for atopy (p=0.086). Conclusion FeNO is able to identify a sputum eosinophil count >/=3% with reasonable accuracy and thresholds which vary according to dose of ICS, smoking and atopy. [less ▲]

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See detailDes romanciers "pour la jeunesse" qui ne le restent pas : Circulation des auteurs entre le champ de la littérature de jeunesse et celui de la littérature générale
Delbrassine, Daniel ULg

in Foucault, Jean, Manson, Michel, Pinhas, Luc (Ed.) L'Edition de jeunesse francophone face à la mondialisation (2010)

Etude d'un corpus d'auteurs contemporains pour adolescents. L'évolution de leur bibliographie entre 2000 et 2007 démontre que beaucoup sont devenus des auteurs "mixtes", c'est-à-dire actifs à l'adresse de ... [more ▼]

Etude d'un corpus d'auteurs contemporains pour adolescents. L'évolution de leur bibliographie entre 2000 et 2007 démontre que beaucoup sont devenus des auteurs "mixtes", c'est-à-dire actifs à l'adresse de deux publics distincts (jeunes et adultes). [less ▲]

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See detailRadiative lifetime measurements and calculations of odd-parity highly excited levels in Ba I
Zhang, W; Palmeri, P; Quinet, Pascal ULg et al

in Physical Review. A (2010), 82

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See detailDummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning
Musat, E.; Roelofs, E.; Bar-Deroma, R. et al

in Radiotherapy & Oncology (2010), 95(2), 218-224

Purpose: Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas. Materials and methods: RT plans provided for dummy cases ... [more ▼]

Purpose: Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas. Materials and methods: RT plans provided for dummy cases were evaluated and compared against expert plans. We analysed: (1) tumour and organs-at-risk delineation, (2) geometric and dosimetric characteristics, (3) planning parameters, compliance with dose prescription and Dmax for OAR (4) indices: RTOG conformity index (CI), coverage factor (CF), tissue protection factor (PF); conformity number (CN = PF× CF); dose homogeneity in PTV (U). Results: Forty-one RT plans were evaluated. Only two (5%) centres were requested to repeat CTV-PTV delineations. Three (7%) plans had a significant under-dosage and dose homogeneity in one deviated > 10%. Dose distribution was good with mean values of 1.5, 1, 0.68, and 0.68 (ideal values = 1) for CI, CF, PF, and CN, respectively. CI and CN strongly correlated with PF and they correlated with PTV. Planning with more beams seems to increase PTV Dmin, improving CF. U correlated with PTV Dmax. Conclusion: Preliminary results of the dummy run procedure indicate that most centres conformed to protocol requirements. To quantify plan quality we recommend systematic calculation of U and either CI or CN, both of which measure the amount of irradiated normal brain tissue. © 2010 Elsevier Ireland Ltd. All rights reserved. [less ▲]

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See detailVaccinations in patients with immune-mediated inflammatory diseases.
Rahier, Jean-Francois; Moutschen, Michel ULg; Van Gompel, Alfons et al

in Rheumatology (2010), 49(10), 1815-27

Patients with immune-mediated inflammatory diseases (IMID) such as RA, IBD or psoriasis, are at increased risk of infection, partially because of the disease itself, but mostly because of treatment with ... [more ▼]

Patients with immune-mediated inflammatory diseases (IMID) such as RA, IBD or psoriasis, are at increased risk of infection, partially because of the disease itself, but mostly because of treatment with immunomodulatory or immunosuppressive drugs. In spite of their elevated risk for vaccine-preventable disease, vaccination coverage in IMID patients is surprisingly low. This review summarizes current literature data on vaccine safety and efficacy in IMID patients treated with immunosuppressive or immunomodulatory drugs and formulates best-practice recommendations on vaccination in this population. Especially in the current era of biological therapies, including TNF-blocking agents, special consideration should be given to vaccination strategies in IMID patients. Clinical evidence indicates that immunization of IMID patients does not increase clinical or laboratory parameters of disease activity. Live vaccines are contraindicated in immunocompromized individuals, but non-live vaccines can safely be given. Although the reduced quality of the immune response in patients under immunotherapy may have a negative impact on vaccination efficacy in this population, adequate humoral response to vaccination in IMID patients has been demonstrated for hepatitis B, influenza and pneumococcal vaccination. Vaccination status is best checked and updated before the start of immunomodulatory therapy: live vaccines are not contraindicated at that time and inactivated vaccines elicit an optimal immune response in immunocompetent individuals. [less ▲]

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See detailLa portée critique de l'analyse des idées d'existence et de néant
Caeymaex, Florence ULg

in François, Arnaud (Ed.) L'évolution créatrice de Bergson (2010)

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