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See detailIdentification of a novel snake peptide displaying high affinity and antagonist behaviour for the alpha2-adrenoreceptors
Rouget, Céline; Quinton, Loïc ULg; Maïga, Arhamatoulaye et al

in British Journal of Pharmacology (2010), 161

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See detailPourquoi rire ? "Philèbe", 47d–50e
Gavray, Marc-Antoine ULg

in Brisson, Luc; Dillon, John (Eds.) Plato’s Philebus. Selected Papers from the Eighth Symposium Platonicum (2010)

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See detailOperational multipartite entanglement classes for symmetric photonic qubit states
Kiesel, N.; Wieczorek, W.; Krins, Stéphanie ULg et al

Poster (2010)

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See detailA docetaxel-induced rash on a radiotherapy port.
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2010), 11(5), 367-9

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See detailTechnisch rapport TR3 MP0.4 - Case study industriegebouw
Pyl, Lincy; Lansival, Jean-Baptiste; Hanus, François ULg

Report (2010)

Ce rapport décrit le calcul de la résistance au feu d'un hall industriel sous feu naturel et contient trois parties : l'évaluation de la distribution de température dans le compartiment, l'échauffement de ... [more ▼]

Ce rapport décrit le calcul de la résistance au feu d'un hall industriel sous feu naturel et contient trois parties : l'évaluation de la distribution de température dans le compartiment, l'échauffement de la structure et sa stabilité. [less ▲]

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See detailIntroduction : migration and ethnic studies in Europe
Martiniello, Marco ULg; Rath, Jan

in Martiniello, Marco; Rath, Jan (Eds.) Selected Studies in International Migration and Immigrant Incorporation (2010)

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See detailPneumoinie à pseudomonas aeruginosa chez le python indien
Gandar; Szalo; Etienne et al

in Monde Vétérinaire (Le) : European Veterinary Magazine (2010), 107

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See detailDe la norme en classe de français : une problématique soumise aux effets des représentations ?
El Karouni, Salima; Lucchini, Silvia ULg

in Dialogues et Cultures (2010), III(55), 1387-1396

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See detailAllosteric block of KCa2 channels by apamin
Lamy, Cédric ULg; Goodchild, Samuel J; Weatherall, Kate L et al

in Journal of Biological Chemistry (2010)

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See detailHabitability from stars to cells
Javaux, Emmanuelle ULg; Dehant, Véronique

in Astronomy and Astrophysics Review (2010), 18(DOI: 10.1007/s00159-010-0030-4), 1-34

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See detailAnxiety in adult female mice following perinatal exposure to chlorpyrifos.
Braquenier, Jean-Baptiste; Quertemont, Etienne ULg; Tirelli, Ezio ULg et al

in Neurotoxicology & Teratology (2010), 32

Epidemiologic studies suggested a possible link between prenatal exposure to organophosphate insecticides (OP) and long-term mental delay and some behavioral troubles. Experimental studies in rats and ... [more ▼]

Epidemiologic studies suggested a possible link between prenatal exposure to organophosphate insecticides (OP) and long-term mental delay and some behavioral troubles. Experimental studies in rats and mice have confirmed that a relatively short exposure to low doses of OP such as chlorpyrifos (CPF) during specific perinatal periods decreased anxiety-like behaviors. In the present study, we report that chronic perinatal exposure (GD15-PND14) to low doses of CPF leads to an increase (and not a decrease) in anxiety-like behaviors of female mouse offspring. Pregnant or lactating female mice were exposed to CPF (0.2; 1; or 5 mg/kg day) by oral treatment during 18 consecutive days. Following a recovery period of several weeks, the anxiety of adult female offspring was determined using neurobehavioral tests (elevated plus-maze and light/dark box tests). Our results showed that CPF-exposed female offspring were more anxious than controls. In addition, the magnitude of anxiety profile alterations depended on the level of exposure to CPF during gestation and lactation with a maximal effect observed at the 1 mg/kg day dose. Our results confirm that OP exposure during the perinatal period can induce long-term alterations in mouse anxiety-like behaviors and suggest that the routes of administration and the duration of OP exposure during brain development may be factors to consider when studying the development of anxiety. [less ▲]

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See detailIntroduction to the Natural Anticipator and the Artificial Anticipator
Dubois, Daniel ULg

in Dubois, Daniel (Ed.) COMPUTING ANTICIPATORY SYSTEMS (2010)

This short communication deals with the introduction of the concept of anticipator, which is one who anticipates, in the framework of computing anticipatory systems. The definition of anticipation deals ... [more ▼]

This short communication deals with the introduction of the concept of anticipator, which is one who anticipates, in the framework of computing anticipatory systems. The definition of anticipation deals with the concept of program. Indeed, the word program, comes from “pro-gram” meaning "to write before" by anticipation, and means a plan for the programming of a mechanism, or a sequence of coded instructions that can be inserted into a mechanism, or a sequence of coded instructions, as genes or behavioural responses, that is part of an organism. Any natural or artificial programs are thus related to anticipatory rewriting systems, as shown in this paper. All the cells in the body, and the neurons in the brain, are programmed by the anticipatory genetic code, DNA, in a low-level language with four signs. The programs in computers are also computing anticipatory systems. It will be shown, at one hand, that the genetic code DNA is a natural anticipator. As demonstrated by Nobel laureate McClintock [8], genomes are programmed. The fundamental program deals with the DNA genetic code. The properties of the DNA consist in self-replication and self-modification. The self-replicating process leads to reproduction of the species, while the self-modifying process leads to new species or evolution and adaptation in existing ones. The genetic code DNA keeps its instructions in memory in the DNA coding molecule. The genetic code DNA is a rewriting system, from DNA coding to DNA template molecule. The DNA template molecule is a rewriting system to the Messenger RNA molecule. The information is not destroyed during the execution of the rewriting program. On the other hand, it will be demonstrated that Turing machine is an artificial anticipator. The Turing machine is a rewriting system. The head reads and writes, modifying the content of the tape. The information is destroyed during the execution of the program. This is an irreversible process. The input data are lost. [less ▲]

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See detailDistribution of temperature in steel and composite beams and joints under natural fire
Hanus, François; Franssen, Jean-Marc ULg

in Cahier Scientifique - Revue Technique Luxembourgeoise (2010), 2

The present article describes the existing methods and recommendations for the evaluation of temperature profiles in steel beams and joints covered by a concrete slab. Then, modifications and improvements ... [more ▼]

The present article describes the existing methods and recommendations for the evaluation of temperature profiles in steel beams and joints covered by a concrete slab. Then, modifications and improvements to the existing methods are proposed in order to predict more accurately temperatures at the level of the top flange of the beam by accounting for heat fluxes between the steel elements and the concrete slab. The two methods presented in this article differ by the degree of simplicity, the field of applicability and the accuracy of the predicted results. Comparisons with numerical simulations performed in the finite element program SAFIR have been described for the validation of these new methods. It is assumed in these numerical models that the contact between the steel profile and the concrete slab is perfect. The “original” Lumped Capacity Method gives globally good predictions of temperature in steel and composite beams and joints but does not integrate heat fl uxes between the steel elements and the concrete slab. This leads to an over-estimation of temperature in the steel elements during the heating phase and to an under-estimation of temperature during the cooling phase. In order to take these fluxes into consideration in the evaluation of the top flange temperature, it is suggested in the first proposed method to integrate a part of the concrete slab into the heated surface or volume considered in the Lumped Capacitance Method. The Composite Section Method correctly predicts temperature at the level of the top flange under ISO fire or during the heating phase of parametrical fire curves but a delay is observed between these analytical results and those obtained from numerical simulations performed in SAFIR software. In a second method, called Heat Exchange Method, it is proposed to calculate separately the heat fluxes between, on one side, the top flange and, on the other side, the gases of the compartment, the rest of the steel section and the concrete slab. The temperatures given by this latter method are in very good agreement with those obtained from FE models. The use of this method is really less fastidious than the use of FE models, especially for joints, but is limited to a certain type of fire curves (parametrical fire curves defined in the Annex A of the EN 1991-1-2). Finally, a bilinear temperature profi le has been proposed to interpolate the analytically-calculated temperatures at the level of the top and bottom flanges on the total height. This procedure is simple and shows a good agreement with the numerical results in 2-D beam sections and 3-D joint zones during the heating and cooling phases of parametric fire curves. [less ▲]

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See detailDans le scriptorium de Jean-Philippe Toussaint
Demoulin, Laurent ULg

in Textyles : Revue des Lettres Belges de Langue Française (2010), 38

Il s'agit de l'étude de quelques pages de brouillon des romans de Jean-Philippe Toussaint L'Appareil-Photo et La Vérité sur Marie

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See detailStructure-based design of selective high-affinity telomeric quadruplex-binding ligands
Lombardo, Caterina M.; Martínez, Iria S.; Haider, Shozeb et al

in Chemical Communications (2010), 46

A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting ... [more ▼]

A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept [less ▲]

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See detailIsotope coded protein label quantification of serum proteins--comparison with the label-free LC-MS and validation using the MRM approach.
Turtoi, Andrei ULg; Mazzucchelli, Gabriel ULg; De Pauw, Edwin ULg

in Talanta (2010), 80(4), 1487-95

Protein quantification based upon mass spectrometry is gaining ground in diverse applications of biological and clinical relevance. The present article focuses on one of the most complex biological fluids ... [more ▼]

Protein quantification based upon mass spectrometry is gaining ground in diverse applications of biological and clinical relevance. The present article focuses on one of the most complex biological fluids - serum - and provides a novel ICPL based quantification protocol. The results are compared to a label-free (data independent alternate scanning) absolute quantification method. The validation is performed using MRM based protein quantification technique. Regarding the ICPL approach, serum samples used in this study were depleted of high abundant proteins, labeled with ICPL and fractionated according to their respective pI (3-5, 5-7 and 7-12). The samples were further subjected to tryptic digestion followed by treatment with the Glu-C enzyme. The peptides were analyzed on a 2D-nano-LC system using four different concentrations of salt injections (45, 75, 150 and 500 mM ammonium acetate). The LC system was connected on-line with the electrospray ion-trap mass spectrometer. For the label-free quantification the serum samples were depleted and digested with trypsin. A proteome-wide comparison was performed using highly reproducible LC and data independent alternate scanning in conjunction with a high mass accuracy orthogonal time-of-flight mass spectrometer. Selected proteins, found by both methods, were validated using the MRM approach. For this purpose non-depleted tryptically digested serum samples were analyzed by LC coupled with a triple-quadrupole MS. The relative protein quantification using ICPL and mass spectrometry allowed for the detection of approximately 200 proteins, whereas about 2/3 of those contained the ICPL label and could therefore be quantified. Label-free approach used no fractionation, less sample and was able to identify and quantify over 110 proteins. The identified proteins covered generally 3-4 orders of magnitude of protein concentration in human serum. Changes in relative abundance of eight proteins were validated using MRM. This study, for the first time, shows the ability of the relative protein quantification based upon ICPL and 2D-LC-MS/MS to quantify serum biomarkers. It provides two additional label-free approaches that could validate and bring additional value to the label-based results, offering a starting point for comprehensive proteomics studies aiming at revealing biomarkers of clinical relevance. [less ▲]

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See detailEffect of an electric field on an intermittent granular flow
Mersch, Eric ULg; Lumay, Geoffroy ULg; Boschini, Frédéric ULg et al

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2010), 81

Granular gravity driven flows of glass beads have been observed in a silo with a flat bottom. A dc high electric field has been applied perpendicularly to the silo to tune the cohesion. The outlet mass flow ... [more ▼]

Granular gravity driven flows of glass beads have been observed in a silo with a flat bottom. A dc high electric field has been applied perpendicularly to the silo to tune the cohesion. The outlet mass flow has been measured. An image subtraction technique has been applied to visualize the flow geometry and a spatiotemporal analysis of the flow dynamics has been performed. The outlet mass flow is independent of voltage, but a transition from funnel flow to rathole flow is observed. This transition is of probabilistic nature and an intermediate situation exists between the funnel and the rathole situations. At a given voltage, two kinds of flow dynamics can occur: a continuous flow or an intermittent flow. The electric field increases the probability to observe an intermittent flow. [less ▲]

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See detailThe IMA-CNMNC dominant-constituent rule revisited and extended
Hatert, Frédéric ULg; Burke, Ernst

in Elements (2010), 6

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See detailDialogue social et changement institutionnel. Le cas de la mise en oeuvre d'une directive européenne
Orianne, Jean-François ULg

in Droit et société (2010), 75

Cet article prend pour objet la mise en œuvre, en Belgique, d’une directive européenne établissant un cadre général relatif à l’information et à la consultation des travailleurs dans la Communauté ... [more ▼]

Cet article prend pour objet la mise en œuvre, en Belgique, d’une directive européenne établissant un cadre général relatif à l’information et à la consultation des travailleurs dans la Communauté européenne : la directive 2002/14/CE. L’auteur utilise le « modèle des trois i » en sciences politiques pour analyser la mise en œuvre particulièrement laborieuse qui cristallise un processus de changement ou d’apprentissage institutionnel, perceptible en Belgique, à travers la redéfinition des principales institutions du dialogue social. [less ▲]

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