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See detailMesure du volume de fin d'expiration (VFE) en cours de ventilation contrôlée après chirurgie cardiaque
MARCHAL, Vanessa; SOTTIAUX, Thierry; PUJOL, B et al

in Réanimation (2010), 19(Suppl 1), 180325

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See detailMolecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation.
Yevenes, Gonzalo E; Moraga-Cid, Gustavo; Avila, Ariel et al

in Journal of Biological Chemistry (2010), 285(39), 30203-13

It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure. Thus, the differential ethanol ... [more ▼]

It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure. Thus, the differential ethanol sensitivity of diverse GlyR isoforms and mutants was explained by the presence of specific residues in putative alcohol pockets. Here, we demonstrate that ethanol sensitivity in two ligand-gated ion receptor members, the GlyR adult alpha(1) and embryonic alpha(2) subunits, can be modified through selective mutations that rescued or impaired Gbetagamma modulation. Even though both isoforms were able to physically interact with Gbetagamma, only the alpha(1) GlyR was functionally modulated by Gbetagamma and pharmacological ethanol concentrations. Remarkably, the simultaneous switching of two transmembrane and a single extracellular residue in alpha(2) GlyRs was enough to generate GlyRs modulated by Gbetagamma and low ethanol concentrations. Interestingly, although we found that these TM residues were different to those in the alcohol binding site, the extracellular residue was recently implicated in conformational changes important to generate a pre-open-activated state that precedes ion channel gating. Thus, these results support the idea that the differential ethanol sensitivity of these two GlyR isoforms rests on conformational changes in transmembrane and extracellular residues within the ion channel structure rather than in differences in alcohol binding pockets. Our results describe the molecular basis for the differential ethanol sensitivity of two ligand-gated ion receptor members based on selective Gbetagamma modulation and provide a new mechanistic framework for allosteric modulations of abuse drugs. [less ▲]

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See detailRegain d'intérêt pour la Kétamine
Marchant, Nicolas; Joris, Jean ULg

in Revue Médicale de Liège (2010), 65(1), 29-34

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See detailRegards sur les industries laminaires du Paléolithique moyen en Asie centrale
Flas, Damien ULg; Krivoshapkin, A.; Kolobova, K. et al

Conference (2010)

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See detailEffects of methionine sources in interaction with dietary protein content on performance and oxidative status of broiler chickens
Swennen, Q.; Buyse, Johan; Mercier, Yves et al

Poster (2010)

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See detailContrasting response of European forest and grassland energy exchange to heatwaves
Teuling, A. J.; Seneviratne, S. I.; Stöckli, R. et al

in Nature Geoscience (2010), 3(10), 722-727

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See detailFunctionalization of carbon xerogels for the preparation of Pd/C catalysts by grafting of Pd complex
Diverchy, Chantal; Hermans, Sophie; Job, Nathalie ULg et al

in Studies in Surface Science and Catalysis (2010), 175

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See detailValidation of a method for the quantitation of ghrelin and unacylated ghrelin by HPLC.
Rozet, Eric ULg; Staes, Edith; Ucakar, Bernard et al

in Journal of Pharmaceutical & Biomedical Analysis (2010), 51(3), 633-9

An HPLC/UV method was first optimized for the separation and quantitation of human acylated and unacylated (or des-acyl) ghrelin from aqueous solutions. This method was validated by an original approach ... [more ▼]

An HPLC/UV method was first optimized for the separation and quantitation of human acylated and unacylated (or des-acyl) ghrelin from aqueous solutions. This method was validated by an original approach using accuracy profiles based on tolerance intervals for the total error measurement. The concentration range that achieved adequate accuracy extended from 1.85 to 59.30microM and 1.93 to 61.60microM for acylated and unacylated ghrelin, respectively. Then, optimal temperature, pH and buffer for sample storage were determined. Unacylated ghrelin was found to be stable in all conditions tested. At 37 degrees C acylated ghrelin was stable at pH 4 but unstable at pH 7.4, the main degradation product was unacylated ghrelin. Finally, this validated HPLC/UV method was used to evaluate the binding of acylated and unacylated ghrelin to liposomes. [less ▲]

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See detailLe Comité France-Amérique et l’Alliance française à Montréal
Dozo, Björn-Olav ULg

in Luneau, Marie-Pier; Mellot, Jean-Dominique; Montreuil, Sophie (Eds.) et al Passeurs d'histoire(s). Figures des relations France-Québec en histoire du livre (2010)

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See detailImplications of differents design assumptions in direct displacement-based design of RC frames
Massena, B.; Bento, R.; Degée, Hervé ULg

in Proceedings of the 8th Sismica Conference (2010)

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See detailCritical analysis of the WORLDNET freight flow matrices
Chevalier, Simon; Limbourg, Sabine ULg

E-print/Working paper (2010)

The growing trade between Europe and the rest of the world and the enlargement of the European Union has led the European Commission’s Directorate-General for Energy and Transport to fund Worldnet – ... [more ▼]

The growing trade between Europe and the rest of the world and the enlargement of the European Union has led the European Commission’s Directorate-General for Energy and Transport to fund Worldnet – Worldwide Cargo Flows – within the Framework 6 research project under the Scientific Support to Policies initiative. The main outputs have been an extended freight origin-destination database for the year 2005, extended road and rail networks, and new maritime and air-cargo networks. Moreover, these outputs were developed according to TRANSTOOLS (Tools for TRansport forecasting ANd Scenario testing) specifications. Due to the magnitude of the project and to the consequences that its results could generate in transportation planning at European level, this study assesses the validity of the freight origin-destination matrix. Our analysis indicates multiple problem cases, inconsistencies and aberrations. [less ▲]

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See detailJoe G. Pinelli, dans le no man’s land de la bande dessinée
Paques, Frédéric ULg

in Textyles : Revue des Lettres Belges de Langue Française (2010), 36-37

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See detailDes romanciers "pour la jeunesse" qui ne le restent pas : Circulation des auteurs entre le champ de la littérature de jeunesse et celui de la littérature générale
Delbrassine, Daniel ULg

in Foucault, Jean, Manson, Michel, Pinhas, Luc (Ed.) L'Edition de jeunesse francophone face à la mondialisation (2010)

Etude d'un corpus d'auteurs contemporains pour adolescents. L'évolution de leur bibliographie entre 2000 et 2007 démontre que beaucoup sont devenus des auteurs "mixtes", c'est-à-dire actifs à l'adresse de ... [more ▼]

Etude d'un corpus d'auteurs contemporains pour adolescents. L'évolution de leur bibliographie entre 2000 et 2007 démontre que beaucoup sont devenus des auteurs "mixtes", c'est-à-dire actifs à l'adresse de deux publics distincts (jeunes et adultes). [less ▲]

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See detailDésir de pouvoir et incertain pouvoir du désir
Delhalle, Nancy ULg

in Alternatives théâtrales (2010)

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