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See detailThe nucleolus: structure/function relationship in RNA metabolism.
Hernandez-Verdun, Daniele; Roussel, Pascal; Thiry, Marc ULg et al

in Wiley Interdisciplinary Reviews. RNA (2010), 1(3), 415-31

The nucleolus is the ribosome factory of the cells. This is the nuclear domain where ribosomal RNAs are synthesized, processed, and assembled with ribosomal proteins. Here we describe the classical ... [more ▼]

The nucleolus is the ribosome factory of the cells. This is the nuclear domain where ribosomal RNAs are synthesized, processed, and assembled with ribosomal proteins. Here we describe the classical tripartite organization of the nucleolus in mammals, reflecting ribosomal gene transcription and pre-ribosomal RNA (pre-rRNA) processing efficiency: fibrillar center, dense fibrillar component, and granular component. We review the nucleolar organization across evolution from the bipartite organization in yeast to the tripartite organization in humans. We discuss the basic principles of nucleolar assembly and nucleolar structure/function relationship in RNA metabolism. The control of nucleolar assembly is presented as well as the role of pre-existing machineries and pre-rRNAs inherited from the previous cell cycle. In addition, nucleoli carry many essential extra ribosomal functions and are closely linked to cellular homeostasis and human health. The last part of this review presents recent advances in nucleolar dysfunctions in human pathology such as cancer and virus infections that modify the nucleolar organization. [less ▲]

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See detailA structural study of the lithiophilite-sicklerite series
Hatert, Frédéric ULg

in 26th European Crystallographic Meeting, Abstract book (2010)

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See detailImportance of pigtailed macaques (Macaca nemestrina leonina) in seed dispersal: impact on the ecological balance of the tropical rainforest at Khao Yai National Park, Thailand
Albert, Aurélie ULg; Huynen, Marie-Claude ULg; Savini, Tommaso ULg

Poster (2010)

Today, many countries of South-East Asia know about the alarming state of the forests existing on their territory and all agree that it is essential to save the remaining primary forest but also to enable ... [more ▼]

Today, many countries of South-East Asia know about the alarming state of the forests existing on their territory and all agree that it is essential to save the remaining primary forest but also to enable the regeneration of degraded areas, through natural or artificial reforestation. The conservation of tropical rainforests thus passes by the necessity to better understand the plant-animal interactions, and in particular, the seed dispersal process. While following a troop of pigtailed macaques (Macaca nemestrina leonina) accustomed to Man in Khao Yai National park (2 168 km ²), Thailand, we will bring important data relating to these seed dispersers potentially necessary but unfortunately vulnerable. Indeed, this vulnerable but little known species, seems to be essential to maintain forest diversity by dispersing many plant species, particularly those inaccessible to smaller frugivores. First results already show that they disperse many seed species, of all kind of size, in all forest types, from primary forest to secondary forest, thanks to various handling techniques. They also seem to show an adaptation in their daily travels according to resources availability. The next fieldworks will enable us to bring more precision in these results and their temporal variations and thus to conclude on the potential role of Macaca nemestrina in the tropical rainforest regeneration. [less ▲]

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See detailGenome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.
Anttila, Verneri; Stefansson, Hreinn; Kallela, Mikko et al

in Nature Genetics (2010), 42(10), 869-73

Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular ... [more ▼]

Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular markers for migraine have been convincingly established. We identified the minor allele of rs1835740 on chromosome 8q22.1 to be associated with migraine (P = 5.38 x 10, odds ratio = 1.23, 95% CI 1.150-1.324) in a genome-wide association study of 2,731 migraine cases ascertained from three European headache clinics and 10,747 population-matched controls. The association was replicated in 3,202 cases and 40,062 controls for an overall meta-analysis P value of 1.69 x 10(1)(1) (odds ratio = 1.18, 95% CI 1.127-1.244). rs1835740 is located between MTDH (astrocyte elevated gene 1, also known as AEG-1) and PGCP (encoding plasma glutamate carboxypeptidase). In an expression quantitative trait study in lymphoblastoid cell lines, transcript levels of the MTDH were found to have a significant correlation to rs1835740 (P = 3.96 x 10, permuted threshold for genome-wide significance 7.7 x 10. To our knowledge, our data establish rs1835740 as the first genetic risk factor for migraine. [less ▲]

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See detailOptimisatin de la fertilisation azotée des cultures légumières industrielles sous irrigation
Fonder, Nathalie; Heens, Benoit; Xanthoulis, Dimitri ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2010), 14(S1), 103-111

Les essais ont été menés sur un projet de quatre ans et ont testé cinq cultures légumières pour optimiser la fertilisation azotée sous irrigation avec des eaux usées. Le site expérimental était localisé ... [more ▼]

Les essais ont été menés sur un projet de quatre ans et ont testé cinq cultures légumières pour optimiser la fertilisation azotée sous irrigation avec des eaux usées. Le site expérimental était localisé dans le périmètre irrigué développé autour de l’usine de production de légumes surgelés, Hesbaye Frost. Dépendant de la rotation effectuée par le fermier, dont une partie du champ était sous expérimentation, quatre cultures légumières ont été testées (épinard, haricot, carotte et fève) ainsi qu’une céréale (froment d’hiver). Suite à la mise en place des essais et aux conditions climatiques, les cultures d’épinard en 1999 et de froment en 2000 n’ont pas testé le facteur irrigation. Les facteurs d’expérimentation étaient trois niveaux de fertilisation azotée différents par rapport à un témoin ne recevant pas d’azote minéral complémentaire et un apport ou non d’eaux usées par irrigation. L’impact de ces facteurs a été mesuré sur les rendements et les reliquats azotés dans le sol après culture. Pour les trois cultures légumières de haricot, carotte et fève qui ont pu être irriguées, les rendements ont toujours été statistiquement supérieurs lorsqu’il y avait un apport d’eau complémentaire par irrigation avec les eaux usées. Le facteur fumure a favorablement amélioré les rendements de l’épinard et du haricot, ainsi que le taux de protéines des céréales. Par contre, les parcelles de carotte et de fève qui n’avaient reçu aucune fumure azotée pendant respectivement trois et quatre années consécutives et qui n’ont pas reçu de fertilisation pour leur culture, n’ont pas donné des rendements statistiquement inférieurs. Le facteur fumure, quel que soit le niveau de fertilisation, n’a pas donné des rendements différents pour ces deux cultures. Les reliquats azotés dans le sol après récolte sont restés acceptables et normaux tant que la fertilisation recommandée n’était pas dépassée ; la fertilisation maximale testée, outrepassant les conseils de fumure raisonnée, a systématiquement laissé des reliquats en azote minéral dans le sol en quantité néfaste pour l’environnement. Ces résidus azotés principalement localisés dans les horizons supérieurs pouvaient être considérés comme récupérables par une culture intermédiaire piège à nitrate (CIPAN), pour autant que cette dernière soit installée dès la fin de l’été, l’automne étant considéré comme trop tardif pour avoir une influence sur la récupération de l’azote. Quel que soit le niveau de fertilisation, les reliquats azotés étaient importants pour la culture de fève par un phénomène de minéralisation en surface, dus aux conditions climatiques et à la charge en azote minéral apporté par les eaux usées utilisées pour l’irrigation. Les reliquats azotés en conditions de non-irrigation sont significativement plus importants que sous irrigation. L’irrigation permet une meilleure solubilisation de l’azote, ce qui facilite son assimilation par la culture en place et réduit les quantités résiduelles dans le sol après récolte. [less ▲]

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See detailOperational multipartite entanglement classes for symmetric photonic qubit states
Kiesel, N.; Wieczorek, W.; Krins, Stéphanie ULg et al

Poster (2010)

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See detailA hybrid model for the simulation of angiogenesis during bone fracture healing
Geris, Liesbet ULg; Peiffer, Veronique; Gerisch, Alf et al

in Proceedings of the 17th conference of the European Society of Biomechanics (2010)

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See detail« Objet et contenu – L’intentionnalité husserlienne face à son héritage psychologiste »
Gyemant, Maria ULg

in Studia Phaenomenologica (2010), Vol. X

This paper aims to show how Husserl’s concept of intentionality detaches itself from the background of a thorough and recurrent argument against psychologism. Noting that, primarily, the concept of ... [more ▼]

This paper aims to show how Husserl’s concept of intentionality detaches itself from the background of a thorough and recurrent argument against psychologism. Noting that, primarily, the concept of intentionality was recovered by Brentano’s psychology, it seemed to us important to show how Husserl’s intentionality, as it is conceived in the Logical investigations, distinguishes itself from the “intentional inexistence” that Brentano describes in his Psychology from an empirical standpoint. Showing what parts of this psychology were rejected and what was maintained in Husserl’s theory should be the first concern of those who intend to study the phenomenological concept of intentionality. [less ▲]

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See detailDistribution et fréquence d’occurrence des plantes vasculaires au Parc National de la Ruvubu, Burundi.
Masharabu, T; Noret, N; Lejoly, J et al

in European Journal of Scientific Research (2010), 43(4), 466-479

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See detailIdentification of a novel snake peptide displaying high affinity and antagonist behaviour for the alpha2-adrenoreceptors
Rouget, Céline; Quinton, Loïc ULg; Maïga, Arhamatoulaye et al

in British Journal of Pharmacology (2010), 161

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See detail2-Point correlation function of nanostructured materials via the grey-tone correlation function of electron tomograms: A three-dimensional structural analysis of ordered mesoporous silica
Gommes, Cédric ULg; Friedrich, Heiner; De Jongh, Petra E et al

in Acta Materialia (2010), 58

Electron tomography is a unique technique for imaging the microstructure of materials with a nanometer resolution. The signal to noise ratio of electron tomograms is, however, often too low for a reliable ... [more ▼]

Electron tomography is a unique technique for imaging the microstructure of materials with a nanometer resolution. The signal to noise ratio of electron tomograms is, however, often too low for a reliable segmentation-based image analysis. We derive a general relation between the grey-tone correlation function of the tomograms and the 2-point correlation function of the morphology, which enables to analyze quantitatively the grey-tone correlation function with a morphological model of the material. The methodology is applied to SBA-15 ordered mesoporous silica. The three-dimensional grey-tone correlation function obtained from electron tomography is analyzed in terms of a hexagonal array of Gaussian independent pores. The model enables to relate the morphology obtained from the 2-point correlation function to macroscopic characterization data of the material, notably small-angle X-ray scattering and nitrogen adsorption. [less ▲]

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See detailLa femme et son domaine dans Lysistrata d'Aristophane
Vandersmissen, Marc ULg

in Etudes Classiques (Namur, Belgium) (2010), 78(2-3), 169-186

Le présent article étudie le vocabulaire lié à la femme dans la comédie d’Aristophane, Lysistrata. Cette recherche basée sur l’étude des mots dans une œuvre dédiée à la femme en contexte politique permet ... [more ▼]

Le présent article étudie le vocabulaire lié à la femme dans la comédie d’Aristophane, Lysistrata. Cette recherche basée sur l’étude des mots dans une œuvre dédiée à la femme en contexte politique permet d’aborder de nombreux aspects de la société grecque féminine du Ve siècle av. J.-C. [less ▲]

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See detailSocial Enterprise in Europe: At the Crossroads of Market, Public Policies and Third Sector
Defourny, Jacques ULg; Nyssens, Marthe

in Policy and Society (2010), 29(3), 231-232

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See detailCarotid Denervation by Adventitial Stripping: A Promising Treatment of Carotid Sinus Syndrome?
Kolh, Philippe ULg

in European Journal of Vascular and Endovascular Surgery (2010), 39(2), 153-154

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See detailAn Oedometer for Studying Combined Effects of Temperature and Suction on Soils
François, Bertrand ULg; Laloui, Lyesse

in Geotechnical Testing Journal (2010), 33(2),

This paper reports the development of an advanced thermo-hydro-mechanical (THM) oedometer in order to characterize the behavior of soils under combined non-isothermal and unsaturated conditions. The ... [more ▼]

This paper reports the development of an advanced thermo-hydro-mechanical (THM) oedometer in order to characterize the behavior of soils under combined non-isothermal and unsaturated conditions. The simultaneous control of temperature, suction, and stress states within the sample required rigorous calibration. This THM oedometer accommodates samples 80 mm in diameter and 23 mm in height. The applied vertical stresses can reach values of up to 1 MPa, the controlled temperature ranges from 20 to 80°C, and the applied suction is up to 500 kPa. The paper thoroughly discusses the calibration of the device and presents some results of tests performed on sandy silt. [less ▲]

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See detailIron-manganese phosphates with the olivine- and alluaudite-type structures: crystal chemistry and applications
Hatert, Frédéric ULg

in Minerals as Advanced Materials II, Abstract Book (2010)

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See detailCombined PIXE/PIGE and IBIL with external beam applied to the analysis of Merovingian glass beads
Mathis, François ULg; Othmane, G.; Vrielynck, Olivier et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (2010), 268(11-12), 2078-2082

New improvements on our archaeometry line at the cyclotron of the Institute of Nuclear and Atomic Physics and of Spectrometry of the University of Liege have allowed the use of PIXE/PIGE and IBIL in-air ... [more ▼]

New improvements on our archaeometry line at the cyclotron of the Institute of Nuclear and Atomic Physics and of Spectrometry of the University of Liege have allowed the use of PIXE/PIGE and IBIL in-air for the analysis of cultural heritage objects. The extraction is performed through a 100 nm thick Si3N4 window. The detection set-up consists now of two X-ray and one gamma-ray detectors, together with a fiber optic UV-visible spectrometer. This set-up has already been tested for the analysis of modern corundum [1] and is now adapted to the analysis of archaeological artefacts. In this work, we have used it to analyse 216 out of the 5000 Merovingian glass beads that come from the necropolis of Bossut-Gottechain (Belgium), one of the most important ever found in Belgium. The IBA analyses confirmed the typological division of different beads groups through chemical composition that gives us new insights on fabrication techniques of glass matrices and colorants. (C) 2010 Elsevier B.V. All rights reserved. [less ▲]

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See detailPortfolio professionnel : Projet personnel :Enseignement de la nutrition en médecine vétérinaire : un projet d'exercices en ligne visant à susciter l'apprentissage pré-clinique et l'autonomie
Diez, Marianne ULg

Learning material (2010)

Portfolio présentant l'enseignement et une innovation pédagogique sous forme de 2 articles

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See detailA non-destructive testing application solved with A-X geometric eddy-current formulation
Codecasa, Lorenzo; Dular, Patrick ULg; Specogna, Ruben et al

in COMPEL (2010), 29(6), 1606-1615

Purpose – The purpose of this paper is to introduce a perturbation method for the A-X geometric formulation to solve eddy-current problems and apply it to the feasibility design of a non-destructive ... [more ▼]

Purpose – The purpose of this paper is to introduce a perturbation method for the A-X geometric formulation to solve eddy-current problems and apply it to the feasibility design of a non-destructive evaluation device suitable to detect long-longitudinal volumetric flaws in hot steel bars. Design/methodology/approach – The effect of the flaw is accurately and efficiently computed by solving an eddy-current problem over an hexahedral grid which gives directly the perturbation due to the flaw with respect to the unperturbed configuration. Findings – The perturbation method, reducing the cancelation error, produces accurate results also for small variations between the solutions obtained in the perturbed and unperturbed configurations. This is especially required when the tool is used as a forward solver for an inverse problem. The method yields also to a considerable speedup: the mesh used in the perturbed problem can in fact be reduced at a small fraction of the initial mesh, considering only a limited region surrounding the flaw in which the mesh can be refined. Moreover, the full three-dimensional unperturbed problem does not need to be solved, since the source term for computing the perturbation is evaluated by solving a two-dimensional flawless configuration having revolution symmetry. Originality/value – A perturbation method for the A-X geometric formulation to solve eddy-current problems has been introduced. The advantages of the perturbation method for non-destructive testing applications have been described. [less ▲]

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