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See detailBelgian Fabry study: prevalence of Fabry disease in a cohort of 1000 young patients with cerebrovascular disease.
Brouns, Raf; Thijs, Vincent; Eyskens, Francois et al

in Stroke (2010), 41(5), 863-8

BACKGROUND AND PURPOSE: Data on the prevalence of Fabry disease in patients with central nervous system pathology are limited and controversial. In this study, we assessed the prevalence of Fabry disease ... [more ▼]

BACKGROUND AND PURPOSE: Data on the prevalence of Fabry disease in patients with central nervous system pathology are limited and controversial. In this study, we assessed the prevalence of Fabry disease in young patients presenting with cerebrovascular disease in Belgium. METHODS: In this national, prospective, multicenter study, we screened for Fabry disease in 1000 patients presenting with ischemic stroke, transient ischemic attack, or intracranial hemorrhage; unexplained white matter lesions; or vertebrobasilar dolichoectasia. In male patients, we measured alpha-galactosidase A (alpha-GAL A) activity in dried blood spots. Female patients were screened for mutations by exonic DNA sequencing of the alpha-GAL A gene. RESULTS: alpha-GAL A activity was deficient in 19 men (3.5%), although all had normal alpha-GAL A gene sequences. Enzymatic deficiency was confirmed on repeat assessment in 2 male patients (0.4%). We identified missense mutations in 8 unrelated female patients (1.8%): Asp313Tyr (n=5), Ala143Thr (n=2), and Ser126Gly (n=1). The pathogenicity of the 2 former missense mutations is controversial. Ser126Gly is a novel mutation that can be linked to late-onset Fabry disease. CONCLUSIONS: alpha-GAL A deficiency may play a role in up to 1% of young patients presenting with cerebrovascular disease. These findings suggest that atypical variants of Fabry disease with late-onset cerebrovascular disease exist, although the clinical relevance is unclear in all cases. [less ▲]

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See detailThe effectiveness of inpatient geriatric evaluation and management units: a systematic review and meta-analysis.
Van Craen, Katleen; Braes, Tom; Wellens, Nathalie et al

in Journal of the American Geriatrics Society (2010), 58(1), 83-92

OBJECTIVES: To examine how geriatric evaluation and management units (GEMUs) are organized and to examine the effectiveness of admission on a GEMU. DESIGN: Systematic review and meta-analysis based on ... [more ▼]

OBJECTIVES: To examine how geriatric evaluation and management units (GEMUs) are organized and to examine the effectiveness of admission on a GEMU. DESIGN: Systematic review and meta-analysis based on literature search of multiple databases and the references lists of all identified articles and by contacting authors. SETTING: GEMUs. PARTICIPANTS: Elderly people admitted to a GEMU. MEASUREMENTS: Quality of the studies was assessed on 10 criteria. The outcome parameters were mortality, institutionalization, functional decline, readmission, and length of stay at different follow-up points. A random-effects meta-analysis was performed using Hedges' gu and variance of relative risk (RR). RESULTS: GEMUs are organized in a heterogeneous way and the included studies gave no thorough description of comprehensive geriatric assessment (CGA). Involvement of a multidisciplinary team was a key element in all GEMUs. The individual trials showed that admission to a GEMU has one or more favorable effects on the outcomes of interest, with two significant effects in the meta-analysis: less functional decline at discharge from the GEMU (RR=0.87, 95% confidence interval (CI)=0.77-0.99; P=.04) and a lower rate of institutionalization 1 year after discharge (RR=0.78, CI=0.66-0.92; P=.003). For the other outcomes in the meta-analysis, a GEMU did not induce significantly different outcomes than usual care. CONCLUSION: This meta-analysis shows a significant effect in favor of the GEMU group on functional decline at discharge and on institutionalization after 1 year. There is heterogeneity between the studies, poor quality of some randomized controlled trials, and shortage of information about CGA. Multidisciplinary CGA offered in a GEMU may add value to the care for frail older persons admitted to the hospital, but the limitations confirm the need for well-designed studies using explicit CGA and more-structured and -coherent assessment instruments such as the Minimum Data Set Resident Assessment Instrument. [less ▲]

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See detailThe Photoionization Dynamics of Methyl Iodide (CH3I): a joint Photoelectron and Mass Spectrometric Investigation.
Locht, Robert ULg; Dehareng, Dominique ULg; Hottmann, K. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (2010), 43(10), 105101

The threshold photoelectron (TPES) and the photoionization mass spectrometric (PIMS) study of CH3I in the 8-20 eV photon energy range are presented. The interpretation and assignments are supported by ab ... [more ▼]

The threshold photoelectron (TPES) and the photoionization mass spectrometric (PIMS) study of CH3I in the 8-20 eV photon energy range are presented. The interpretation and assignments are supported by ab initio calculations. The TPES shows many new discrete features in the Jahn-Teller split ground X 2E (2A'-2A”) state of CH3I+. A new continuous band starting at about 11.7 eV is detected. These observations are essentially correlated with autoionizing transitions. This interpretation is supported by constant ion state (CIS) spectroscopy. A large enhancement of the transitions to the A 2A and B 2E ionic states is ascribed to large autoionizing contributions. Based on the present calculations, the weak to very weak bands in the 18.0 eV-23.0 eV photon energy range are mainly assigned to 2a1-1 ionization and to double excitations corresponding essentially to the 2e-2 4a11 and 3a1- 1 2e-1 4a11 configurations. The photoionization mass spectrometric study allowed us to investigate in detail the ionization and dissociation of CH3I+ leading to CH2+, CH3+, I+ and CH2I+ from the threshold up to 20 eV photon energy. The experimental data are compared to ab initio calculated dissociation energies. The threshold of appearance of CH3+, I+ and CH2I+ fragments are concentrated in the 12.2-12.7 eV photon energy range. All three exit channels are correlated with the ground state of CH3I+ via nonadiabatic transitions. All three fragment ions have to appear through predissociation of the ionic X 2E state and autoionizing dissociation from the (2E3/2)6p Rydberg state. This interpretation is strongly supported by the photoabsorption spectrum measured recently in the same photon energy range [1]. At higher energies, beside direct or predissociation of the A 2A1 and B 2E states of CH3I+, autoionization is also suggested to contribute to the fragmentation in all decay channels. [less ▲]

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See detailComparison of three methods for fractionation and enrichment of low molecular weight proteins for SELDI-TOF-MS differential analysis
De Bock, Muriel ULg; De Seny, Dominique ULg; Meuwis, Marie-Alice ULg et al

in Talanta (2010), 82

In most diseases, the clinical need for serum/plasma markers has never been so crucial, not only for diagnosis, but also for the selection of the most efficient therapies, as well as exclusion of ... [more ▼]

In most diseases, the clinical need for serum/plasma markers has never been so crucial, not only for diagnosis, but also for the selection of the most efficient therapies, as well as exclusion of ineffective or toxic treatment. Due to the high sample complexity, prefractionation is essential for exploring the deep proteome and finding specific markers. In this study, three different sample preparation methods (i.e., highly abundant protein precipitation, restricted access materials (RAM) combined with IMAC chromatography and peptide ligand affinity beads) were investigated in order to select the best fractionation step for further differential proteomic experiments focusing on the LMW proteome (MW inferior to 40,000 Da). Indeed, the aim was not to cover the entire plasma/serum proteome, but to enrich potentially interesting tissue leakage proteins. These three methods were evaluated on their reproducibility, on the SELDI-TOF-MS peptide/protein peaks generated after fractionation and on the information supplied. The studied methods appeared to give complementary information and presented good reproducibility (below 20%). Peptide ligand affinity beads were found to provide efficient depletion of HMW proteins and peak enrichment in protein/peptide profiles. [less ▲]

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See detailA hybrid tabu search heuristic for a bilevel competitive facility location model
Kucukaydin, Hande ULg; Aras, Necati; Altinel, I. Kuban

in Blesa, Maria J.; Blum, Christian; Raidl, Günther (Eds.) et al Hybrid metaheuristics: 7th International Workshop, HM 2010, Vienna, Austria, October 2010, Proceedings (2010)

We consider a problem in which a firm or franchise enters a market by locating new facilities where there are existing facilities belonging to a competitor. The firm aims at finding the location and ... [more ▼]

We consider a problem in which a firm or franchise enters a market by locating new facilities where there are existing facilities belonging to a competitor. The firm aims at finding the location and attractiveness of each facility to be opened so as to maximize its profit. The competitor, on the other hand, can react by adjusting the attractiveness of its existing facilities, opening new facilities and/or closing existing ones with the objective of maximizing its own profit. The demand is assumed to be aggregated at certain points in the plane and the facilities of the firm can be located at prespecified candidate sites. We employ Huff's gravity-based rule in modeling the behavior of the customers where the fraction of customers at a demand point that visit a certain facility is proportional to the facility attractiveness and inversely proportional to the distance between the facility site and demand point. We formulate a bilevel mixed-integer nonlinear programming model where the firm entering the market is the leader and the competitor is the follower. In order to find a feasible solution of this model, we develop a hybrid tabu search heuristic which makes use of two exact methods as subroutines: a gradient ascent method and a branch-and-bound algorithm with nonlinear programming relaxation. [less ▲]

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See detailAlterations in mitochondrial respiratory function in response to endurance training and endurance racing
Votion, Dominique ULg; Fraipont, Audrey ULg; Goachet, Anne-Gaëlle et al

in Equine Veterinary Journal. Supplement (2010), 42(38), 268-274

Objectives: To determine effects of training and racing on muscle oxidative phosphorylation (OXPHOS) and electron transport system (ETS) capacities in horses with high-resolution respirometry (HRR).

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See detailMathémagie et au-delà
Rigo, Michel ULg

Learning material (2010)

Nous présentons ici 5 tours de magie ne nécessitant aucune habileté particulière de la part de l'apprenti magicien : des tours de cartes, des tours de divination et le célèbre tour du ``barman aveugle ... [more ▼]

Nous présentons ici 5 tours de magie ne nécessitant aucune habileté particulière de la part de l'apprenti magicien : des tours de cartes, des tours de divination et le célèbre tour du ``barman aveugle avec des gants de boxe''. Contrairement au magicien qui ne dévoile jamais ses secrets, ici, nous expliquons que ces tours reposent sur diverses propriétés et constructions mathématiques. Ces dernières débouchent sur de véritables questions de recherche actuelle en théorie des graphes ou en combinatoire des mots et même sur de possibles applications en robotique et automatisation ! Il y en aura donc pour tous les goûts... et tous les niveaux (suivant l'auditoire, l'exposé sera adapté au niveau des élèves de la 4ième à la 6ième secondaire, voire même aux étudiants universitaires). Ce texte présente donc un matériel qui dépassera souvent (et de loin) le ``spectacle''. [less ▲]

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See detailPour un rapport de recherchede qualité ou Comment (ne pas) saloper son mémoire ou TFE
Leclercq, Dieudonné ULg

Learning material (2010)

Ce document liste, pour la production d'un rapport de recherche ou d'un mémoire - Travail de Fin d'Etudes (TFE) une série d'erreurs à éviter, les illustre et en donne la formulation positive : que faire.

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See detailBe Too Kind to a Woman, She’ll Feel Incompetent: Benevolent Sexism Shifts Self-construal and Autobiographical Memories Toward Incompetence
Dumont, Muriel ULg; Sarlet, Marie ULg; Dardenne, Benoît ULg

in Sex Roles (2010), 62

The present study investigated how benevolent (BS) and hostile sexism (HS) shift women’s self-construal and autobiographical memory. Belgian undergraduates (only women, N=45, mean age=21.8) were ... [more ▼]

The present study investigated how benevolent (BS) and hostile sexism (HS) shift women’s self-construal and autobiographical memory. Belgian undergraduates (only women, N=45, mean age=21.8) were confronted either by BS, HS or neutral comments in the context of a job interview. After performing a cognitive task, participants reported the intrusive thoughts that came to their mind during the task. Later, autobiographical memory for self-incompetence was assessed. Performance response latencies were slower after BS than HS. Also, BS generated more disturbing mental intrusions related to the idea of being incompetent than HS. Autobiographical memory similarly indicated greater access for incompetence after BS. Although HS was more aggressive in tone, it did not shift women’s self-construal and autobiographical memories toward incompetence. [less ▲]

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See detailThe Optimal Design of the VSI T2 Control Chart
Faraz, Alireza ULg; Kazemzadeh, R. B.; Heuchenne, Cédric ULg et al

in Journal of Iranian Statistical Society (2010), 9(1), 1-19

Recent studies have shown that the variable sampling interval (VSI) scheme helps practitioners detect process shifts more quickly than the classical scheme (FRS). In this paper, the economically and ... [more ▼]

Recent studies have shown that the variable sampling interval (VSI) scheme helps practitioners detect process shifts more quickly than the classical scheme (FRS). In this paper, the economically and statistically optimal design of the VSI T2 control chart for monitoring the process mean vector is investigated. The cost model proposed by Lorenzen and Vance (1986) is minimized through a genetic algorithm (GA) approach. Then the effects of the costs and operating parameters on the optimal design (OD) of the chart parameters and resulting operating loss through a fractional factorial design is systematically studied and finally, based on the ANOVA results, a Meta model to facilitate implementation in industry is proposed to determine the OD of the VSI T2 control chart parameters from the process and cost parameters [less ▲]

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See detailThe protein Nod2: an innate receptor more complex than previously assumed.
Lecat, Aurore ULg; Piette, Jacques ULg; Legrand-Poels, Sylvie ULg

in Biochemical Pharmacology (2010), 80(12), 2021-31

For almost 10 years, Nod2 has been known as a cytosolic innate receptor able to sense peptidoglycan from Gram-positive and -negative bacteria and to trigger RIP2- and NF-kappaB-mediated pro-inflammatory ... [more ▼]

For almost 10 years, Nod2 has been known as a cytosolic innate receptor able to sense peptidoglycan from Gram-positive and -negative bacteria and to trigger RIP2- and NF-kappaB-mediated pro-inflammatory and antibacterial response. Mutations in the gene encoding Nod2 in humans have been associated with Crohn's disease (CD). Mechanisms by which Nod2 variants can lead to CD development are still under investigation. The most admitted hypothesis suggests that the impaired function of Nod2 variants in intestinal epithelial and phagocytic cells results in deficiencies in epithelial-barrier function which subsequently lead to increased bacterial invasion and inflammation at intestinal sites. Very recent results have just reinforced this hypothesis by demonstrating that Nod2 wild-type (unlike Nod2 variants) could mediate autophagy, allowing an efficient bacterial clearance and adaptative immune response. Other recent data have attributed new roles to Nod2. Indeed, Nod2 has been shown to activate antiviral innate immune responses involving IRF3-dependent IFN-beta production after viral ssRNA recognition through a RIP2-independent mechanism requiring the mitochondrial adaptor protein MAVS. Recently, Nod2 has been also shown to be exquisitely tuned to detect mycobacterial infections and mount a protective immunity against these pathogens. [less ▲]

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See detailCytokine expression by Aspergillus fumigatus stimulated peripheral blood mononuclear cells from dogs with sino-nasal aspergillosis.
Vanherberghen, Morgane ULg; Bureau, Fabrice ULg; Peters, I. R. et al

in Proceedings of the 20th Annual Congress of the ECVIM-CA (2010)

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See detailQuand les tangentes étaient touchantes
Bair, Jacques ULg; Henry, Valérie ULg

in Tangente Sup (2010), 54

Exposé moderne d'un algorithme, initialement trouvé par le belge Sluse (1622-1685), pour déterminer la tangente à une courbe plane.

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See detailMonitoring endocrine profiles for prediction of stillbirth in Holstein-Friesian dairy cattle
Szenci, O.; Bajcsy, A. C.; Bryd, E. et al

Poster (2010)

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See detailAnalyse expérimentale de l'influence des largeurs d'alvéoles sur la débitance des déversoirs en touches de piano
Machiels, Olivier ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Houille Blanche (2010), (2), 22-28

Within the framework of updating the release and storage capacities of existing reservoirs, the use of piano keys weirs (PKW) can be an interesting alternative either to increase the discharge of a free ... [more ▼]

Within the framework of updating the release and storage capacities of existing reservoirs, the use of piano keys weirs (PKW) can be an interesting alternative either to increase the discharge of a free weir without changing the weir layout or the reservoir level, or increase the reservoir level before discharge while keeping the weir layout and the level of safety. In order to help to the understanding of the behavior of this new type of weirs and to characterize their hydraulic potential, the results of an experimental study with for objectives to study the influence of the relative width of the inlets and outlets on the hydrodynamic characteristics of the structure are presented. A process oriented analytical formulation for the evaluation of the discharge coefficient of the PKW tested on scale models is proposed. It is in satisfactory agreement with the experimental results and leads to an objective evaluation of the optimal ratio of the alveoli widths. [less ▲]

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See detailValidation of Hospital Administrative Dataset for adverse event screening.
Verelst, S.; Jacques, Jessica ULg; Van den Heede, K. et al

in Quality & Safety in Health Care (2010)

Objective To assess whether the Belgian Hospital Discharge Dataset (B-HDDS) is a valid source for the detection of adverse events in acute hospitals. Design, setting and participants Retrospective review ... [more ▼]

Objective To assess whether the Belgian Hospital Discharge Dataset (B-HDDS) is a valid source for the detection of adverse events in acute hospitals. Design, setting and participants Retrospective review of 1515 patient records in eight acute Belgian hospitals for the year 2005. Main outcome measures Predictive value of the B-HDDS and medical record reviews and degree of correspondence between the B-HDDS and medical record reviews for five indicators: pressure ulcer, postoperative pulmonary embolism or deep vein thrombosis, postoperative sepsis, ventilator-associated pneumonia and postoperative wound infection. Results Postoperative wound infection received the highest positive predictive value (62.3%), whereas postoperative sepsis and ventilator-associated pneumonia were rated as only 44.2% and 29.9% respectively. Excluding present on admission from the screening substantially decreased the positive predictive value of pressure ulcer from 74.5% to 54.3%, as pressure ulcers present on admission were responsible for more B-HDDS-medical record mismatches than any other indicator. Over half (56.8%) of false-positive cases for postoperative sepsis were due to a lack of specificity of the ICD-9-CM code, whereas in 58.6% of false-positive cases for ventilator-associated pneumonia, clinical criteria appeared to be too stringent. Conclusions The B-HDDS has the potential to accurately detect some but not all adverse events. Adding a code 'present on admission' and improving the ICD-9-CM codes might already partially improve the correspondence between the B-HDDS and the medical record review. [less ▲]

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See detailEffects of face and voice learning on access to semantic information from names.
Barsics, Catherine ULg

in Perception (2010), 39 supplement

Several studies showed that it is more difficult to retrieve semantic information from recognized voices than from recognized faces. However, earlier studies that investigated the recall of biographical ... [more ▼]

Several studies showed that it is more difficult to retrieve semantic information from recognized voices than from recognized faces. However, earlier studies that investigated the recall of biographical information following person recognition used stimuli that were pre-experimentally familiar to the participants, such as famous people’s voices and faces. The present study was designed in order to allow a stricter control of frequency exposure with both types of stimuli (voices and faces) and to ensure the absence of identity cues in the spoken extracts. In the present study, subjects had to associate lexical (i.e., name) and semantic information (i.e., occupation) with faces or voices. Interestingly, when asked later to recall semantic information being cued by the person’s names, participants provided significantly more occupations for the targets that had been previously associated with faces than with voices. Moreover, participants’ performance was not significantly different when names and occupation were associated with voices compared with dog’s faces, whose complexity is similar to that of human faces, but for which we have poorer discrimination abilities. These results and their implications for person recognition models, as well as the potential role of the relative distinctiveness of faces and voices, are discussed. [less ▲]

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