References of "2010"
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See detailFlow of magnetized grains in a rotating drum
Lumay, Geoffroy ULg; Vandewalle, Nicolas ULg

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2010)

We have experimentally investigated the influence of a magnetic interaction between the grains on the flow of a granular material in a rotating drum.

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See detailExperimental and computational study of the correlation between oxygen tension, cell viability and proliferation in fibrin hydrogels
Demol, J.; Lambrechts, D.; Geris, Liesbet ULg et al

in Proceedings of the 17th conference of the European Society of Biomechanics (2010)

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See detailModified Cap Group Suberoylanilide Hydroxamic Acid Histone Deacetylase Inhibitor Derivatives Reveal Improved Selective Antileukemic Activity
Chanaz, Salmi-Smail; Fabre, Aurélie; Dequiedt, Franck ULg et al

in Journal of Medicinal Chemistry (2010), 53(8)

A series of SAHA cap derivatives was designed and prepared in good-to-excellent yields that varied from 49% to 95%. These derivatives were evaluated for their antiproliferative activity in several human ... [more ▼]

A series of SAHA cap derivatives was designed and prepared in good-to-excellent yields that varied from 49% to 95%. These derivatives were evaluated for their antiproliferative activity in several human cancer cell lines. Antiproliferative activity was observed for concentrations varying from 0.12 to >100 microM, and a molecular modeling approach of selected SAHA derivatives, based on available structural information of human HDAC8 in complex with SAHA, was performed. Strikingly, two compounds displayed up to 10-fold improved antileukemic activity with respect to SAHA; however, these compounds displayed antiproliferative activity similar to SAHA when assayed against solid tumor-derived cell lines. A 10-fold improvement in the leukemic vs peripheral blood mononuclear cell therapeutic ratio, with no evident in vivo toxicity toward blood cells, was also observed. The herein-described compounds and method of synthesis will provide invaluable tools to investigate the molecular mechanism responsible for the reported selectively improved antileukemic activity. [less ▲]

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See detailDummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning
Musat, E.; Roelofs, E.; Bar-Deroma, R. et al

in Radiotherapy & Oncology (2010), 95(2), 218-224

Purpose: Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas. Materials and methods: RT plans provided for dummy cases ... [more ▼]

Purpose: Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas. Materials and methods: RT plans provided for dummy cases were evaluated and compared against expert plans. We analysed: (1) tumour and organs-at-risk delineation, (2) geometric and dosimetric characteristics, (3) planning parameters, compliance with dose prescription and Dmax for OAR (4) indices: RTOG conformity index (CI), coverage factor (CF), tissue protection factor (PF); conformity number (CN = PF× CF); dose homogeneity in PTV (U). Results: Forty-one RT plans were evaluated. Only two (5%) centres were requested to repeat CTV-PTV delineations. Three (7%) plans had a significant under-dosage and dose homogeneity in one deviated > 10%. Dose distribution was good with mean values of 1.5, 1, 0.68, and 0.68 (ideal values = 1) for CI, CF, PF, and CN, respectively. CI and CN strongly correlated with PF and they correlated with PTV. Planning with more beams seems to increase PTV Dmin, improving CF. U correlated with PTV Dmax. Conclusion: Preliminary results of the dummy run procedure indicate that most centres conformed to protocol requirements. To quantify plan quality we recommend systematic calculation of U and either CI or CN, both of which measure the amount of irradiated normal brain tissue. © 2010 Elsevier Ireland Ltd. All rights reserved. [less ▲]

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See detailLa portée critique de l'analyse des idées d'existence et de néant
Caeymaex, Florence ULg

in François, Arnaud (Ed.) L'évolution créatrice de Bergson (2010)

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See detailSéparation de biens
Deguel, François ULg

in Moreau, Pierre (Ed.) Procédures particulières et droit judiciaire de la famille (2010)

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See detailC'est décidé, je bouge !
Henrotin, Yves ULg

Article for general public (2010)

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See detailFoam formation and control in bioreactors
Delvigne, Frank ULg; Lecomte, Jean-Paul

in Michael C. (Ed.) Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology (2010)

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See detailPolymer/carbon nanotube composites for electromagnetic interference réduction
Thomassin, Jean-Michel ULg; Jérôme, Robert ULg; Detrembleur, Christophe ULg et al

in Tjong, S. C.; Mai, Y.-W. (Eds.) Physical properties and applications of polymer nanocomposites (2010)

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See detailHIV-1 V3 envelope deep sequencing for clinical plasma specimens failing in phenotypic tropism assays.
Vandenbroucke, Ina; Van Marck, Herwig; Mostmans, Wendy et al

in AIDS Research and Therapy (2010), 7

ABSTRACT : BACKGROUND : HIV-1 infected patients for whom standard gp160 phenotypic tropism testing failed are currently excluded from co-receptor antagonist treatment. To provide patients with maximal ... [more ▼]

ABSTRACT : BACKGROUND : HIV-1 infected patients for whom standard gp160 phenotypic tropism testing failed are currently excluded from co-receptor antagonist treatment. To provide patients with maximal treatment options, massively parallel sequencing of the envelope V3 domain, in combination with tropism prediction tools, was evaluated as an alternative tropism determination strategy. Plasma samples from twelve HIV-1 infected individuals with failing phenotyping results were available. The samples were submitted to massive parallel sequencing and to confirmatory recombinant phenotyping using a fraction of the gp120 domain. RESULTS : A cut-off for sequence reads interpretation of 5 to10 times the sequencing error rate (0.2%) was implemented. On average, each sample contained 7 different V3 haplotypes. V3 haplotypes were submitted to tropism prediction algorithms, and 4/14 samples returned with presence of a dual/mixed (D/M) tropic virus, respectively at 3%, 10%, 11%, and 95% of the viral quasispecies. V3 tropism prediction was confirmed by gp120 phenotyping, except for two out of 4 D/M predicted viruses (with 3 and 95%) which were phenotypically R5-tropic. In the first case, the result was discordant due to the limit of detection for the phenotyping technology, while in the latter case the prediction algorithms were not computing the viral tropism correctly. CONCLUSIONS : Although only demonstrated on a limited set of samples, the potential of the combined use of "deep sequencing + prediction algorithms" in cases where routine gp160 phenotype testing cannot be employed was illustrated. While good concordance was observed between gp120 phenotyping and prediction of R5-tropic virus, the results suggest that accurate prediction of X4-tropic virus would require further algorithm development. [less ▲]

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See detailMedicion de arboles y masas forestales
Rondeux, Jacques ULg

Book published by Mundi-Prensa Libros s.a. (2010)

Grandes capitulos : Prologos. Grosor de los arboles. Altura de los arboles. Otras caracteristicas dendrométricas de los arboles. Forma y volumen de los arboles. Masa y biomasa lenosas. Tarifas de ... [more ▼]

Grandes capitulos : Prologos. Grosor de los arboles. Altura de los arboles. Otras caracteristicas dendrométricas de los arboles. Forma y volumen de los arboles. Masa y biomasa lenosas. Tarifas de cubicacion. Caracterizacion de masas forestales. Medicion de masas. Crecimiento de arboles y masas. Estimacion de la productividad forestal. Tablas de produccion. Modelos de crecimiento y de produccion. Inventarios por muestreo. A modo de conclusion. Indice Bibliografico. Indice de temas tratados. [less ▲]

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See detailMicrobial bioprocesses : current state and future prospect
Delvigne, Frank ULg

Scientific conference (2010)

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See detailStrategies pour eviter l'inertie et la non-observance dans les essais cliniques.
Jandrain, Bernard ULg; Ernest, Philippe ULg; Radermecker, Régis ULg et al

in Revue Médicale de Liège (2010), 65(5-6), 246-9

Randomised controlled trials play a key role in evidence-based medicine as far as the assessment of both efficacy and safety of drugs is concerned. Various strategies are used to avoid physician's inertia ... [more ▼]

Randomised controlled trials play a key role in evidence-based medicine as far as the assessment of both efficacy and safety of drugs is concerned. Various strategies are used to avoid physician's inertia and to combat patient's non compliance, two pitfalls that may hinder the demonstration of the therapeutic efficacy of the drug. Clinical inertia may be limited by titration, forced or optional, driven by therapeutic targets, or by the use, if necessary, of rescue medications. Compliance may be verified by "pill count". This simple technique allows to exclude non compliant patients when they are detected during the placebo run-in period before randomisation or not to take into account patients with poor compliance in the final evaluation by using a statistical analysis restricted to individuals who have strictly adhered to the study protocol ("per protocol analysis"). Self-monitoring and patient's empowerment in the treatment also contribute to improve drug compliance. Clinicians may take advantage of these approaches derived from clinical trials to improve their daily practice. [less ▲]

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See detailDesign and production of Ti6Al4V bone scaffolds by selective laser melting
Van Bael, Simon; Kerckhofs, Greet ULg; Moesen, Maarten et al

Conference (2010)

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See detailLe biomimétismeau service du développement durable
Jaminon, Martine ULg; Theyskens, Benoît; Vercheval, Catherine et al

Learning material (2010)

Plaquette de l'expositon " Biomimétisme au service du développement durable" : 16 thèmes

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See detailVers une archéologie du savoir en Islam: la méthode de travail d'al-Maqrīzī, historien du XVe siècle
Bauden, Frédéric ULg

in Comptes-Rendus des Séances de l'Académie des Inscriptions et Belles-Lettres (2010), 2009(Janvier-février), 97-110

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See detailLes vers de terre, ingénieurs du sol
Zirbes, Lara ULg

Learning material (2010)

Detailed reference viewed: 45 (7 ULg)
See detailStructures in Fire. Proceedings of the Sixth International Conference
Kodur, Venkatesh; Franssen, Jean-Marc ULg

Book published by DEStech Publications, Inc (2010)

These proceedings contains 122 papers. The covered topics are: steel structures, concrete structures, composite structures, timber structures, connections and fire safety engineering and practice.

Detailed reference viewed: 64 (1 ULg)
See detail"Le droit des biens : une évolution indispensable sans révolution inutile"
Lecocq, Pascale ULg; Vanbrabant, Bernard ULg

in L'avenir de la recherche, Réflexions à l'occasion des leçons inaugurales 2010 (2010)

Detailed reference viewed: 17 (3 ULg)