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See detailSelective osteopontin knockdown exerts anti-tumoral activity in a human glioblastoma model.
Lamour, Virginie ULg; Le Mercier, M.; Lefranc, F. et al

in International Journal of Cancer = Journal International du Cancer (2010), 126

Osteopontin (OPN), a member of the SIBLING (Small Integrin-Binding LIgand N-linked Glycoprotein) family, is overexpressed in human glioblastoma. Higher levels of OPN expression correlate with increased ... [more ▼]

Osteopontin (OPN), a member of the SIBLING (Small Integrin-Binding LIgand N-linked Glycoprotein) family, is overexpressed in human glioblastoma. Higher levels of OPN expression correlate with increased tumor grade and enhanced migratory capacity of tumor cells. Based on these observations, we explored the possibility that knocking down OPN expression in glioblastoma cells could exert an anti-tumoral activity using an avian in vivo glioblastoma model that mimics closely human gliobastoma. Human U87-MG glioma cells transfected with specific anti-OPN small interfering RNAs (siRNAs) were grafted onto the chicken chorio-allantoic membrane (CAM). OPN-deficient U87-MG cells gave rise to tumors that were significantly smaller than tumors formed from untransfected cells (paired t-test, p<0.05). Accordingly, the amount of proliferating cells in OPN-deficient tumors showed a six-fold reduction when compared to control tumors. However, OPN inhibition did not affect significantly tumor-associated angiogenesis. In vitro, OPN-silenced U87-MG and U373-MG cells showed decreased motility and migration. This is the first demonstration that OPN inhibition blocks glioma tumor growth, making this invasion-related protein an attractive target for glioma therapy. (c) 2009 UICC. [less ▲]

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See detailL’édition pour la jeunesse en Belgique francophone : de la nécessité faite vertu à la mondialisation
Habrand, Tanguy ULg

in Pinhas, Luc; Foucault, Jean; Manson, Michel (Eds.) L'édition de jeunesse francophone face à la mondialisation (2010)

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See detailPieds et empreintes de pieds dans les cultes isiaques. Pour une meilleure compréhension des documents hispaniques
Puccio, Laetizia ULg

in Melanges de la Casa de Velazquez (2010), 40(2), 137-155

L’étude des cultes isiaques dans la péninsule Ibérique donne à connaître une série de documents qui représentent un pied sous sa forme réelle ou gravé sur des stèles votives. Se pose alors la question de ... [more ▼]

L’étude des cultes isiaques dans la péninsule Ibérique donne à connaître une série de documents qui représentent un pied sous sa forme réelle ou gravé sur des stèles votives. Se pose alors la question de l’origine de ce symbole. Apparenté aux divinités égyptiennes, il est synonyme de richesse et d’abondance dans la religion pharaonique. À partir de la vallée du Nil, les deux modèles se sont diffusés dans le monde méditerranéen et ils ont atteint l’Hispanie au IIe siècle en passant sans doute par le continent africain. Sans aucune référence dans la littérature antique, l’enquête menée autour de ces représentations et de leurs différentes déclinaisons n’autorise pas à leur attribuer une seule signification. Les pieds de Sérapis comme les stèles dédiées à Isis incarnent le plus souvent l’épiphanie divine, mais ils peuvent également être considérés comme de simples témoignages de dévotion. Lorsque les empreintes de pieds correspondent à celles de la déesse et que les stèles sont situées devant l’entrée du temple, elles pourraient faire référence à un rituel d’accueil. [less ▲]

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See detailDie Römer an Maas und Mosel
Deru, Xavier ULg

Book published by vzabern (2010)

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See detailQuand les tangentes étaient touchantes
Bair, Jacques ULg; Henry, Valérie ULg

in Tangente Sup (2010), 54

Exposé moderne d'un algorithme, initialement trouvé par le belge Sluse (1622-1685), pour déterminer la tangente à une courbe plane.

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See detailEffets des routes et des villes sur la forêt dense dans la province orientale de la République Démocratique du Congo
Bamba, I; Yedmel, M S; Bogaert, Jan ULg

in European Journal of Scientific Research (2010), 43(3), 417-429

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See detailProduction of three anti-listerial peptides by Lactobacillus curvatus in MRS broth.
Ghalfi, H.; Benkerroum, N.; Ongena, Marc ULg et al

in Food Research International (2010), (43), 33-39

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See detailSelective epitaxial growth of III-V semiconductor on large-area Si substrate for advanced logic CMOS technologies
Nguyen, Ngoc Duy ULg; Brammertz, Guy; Wang, Gang et al

Conference (2010)

The continued downscaling of the metal-oxide semiconductor (MOS) transistor for sub-22 nm logic circuits with boosted performance will require the introduction of new channel materials with carrier ... [more ▼]

The continued downscaling of the metal-oxide semiconductor (MOS) transistor for sub-22 nm logic circuits with boosted performance will require the introduction of new channel materials with carrier mobility higher than that of Si, such as Ge for pMOS. The use of III-V compounds for nMOS devices poses however additional challenges related to the hetero-epitaxial growth of a polar semiconductor on a non-polar surface. Furthermore, these high-mobility materials have to be fabricated on large-area Si substrates, in the perspective of application in a standard low-cost very-large-scale integration scheme. In this work, we report on the successful growth of GaAs on 200 mm Si wafers by means of metal-organic vapor deposition using a modified Crius Close-Coupled Showerhead system from AIXTRON AG. We used Si (100) wafers with off-axis orientation (6° miscut towards <111>) in order to avoid the formation of anti-phase domains which lead to Ga-Ga and As-As bonds at their boundaries that have strong detrimental effects on the electrical conduction. In our approach, based on Ge virtual substrates with low threading dislocation (TD) density, the lattice mismatch between Si and GaAs is accommodated and, thus, no additional TD is introduced in the deposited III-V film. Our results show that smooth GaAs layers can be epitaxially grown on large-area Si substrates with high wafer-scale thickness uniformity. The excellent quality of the deposited GaAs was confirmed by photoluminescence and electron microscopy. Our process also demonstrates very high selectivity on patterned wafers with SiO2 mask and enabled the fabrication of capacitor structures using an integration process flow very similar to standard high volume Si manufacturing lines. The capacitance-voltage characteristics were similar to the ones obtained on a bulk GaAs substrate, and showed extremely tight within-wafer and wafer-to-wafer distributions as is standard to Si manufacturing. [less ▲]

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See detailCotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning.
Baron, Frédéric ULg; Lechanteur, Chantal ULg; Willems, Evelyne ULg et al

in Biology of Blood & Marrow Transplantation (2010), 16(6), 838-47

Recent studies have suggested that coinfusion of mesenchymal stem cells (MSCs) the day of hematopoietic cell transplantation (HCT) might promote engraftment and prevent graft-versus-host disease (GVHD ... [more ▼]

Recent studies have suggested that coinfusion of mesenchymal stem cells (MSCs) the day of hematopoietic cell transplantation (HCT) might promote engraftment and prevent graft-versus-host disease (GVHD) after myeloablative allogeneic HCT. This prompted us to investigate in a pilot study whether MSC infusion before HCT could allow nonmyeloablative (NMA) HCT (a transplant strategy based nearly exclusively on graft-versus-tumor effects for tumor eradication) from HLA-mismatched donors to be performed safely. Twenty patients with hematologic malignancies were given MSCs from third party unrelated donors 30-120 minutes before peripheral blood stem cells (PBSCs) from HLA-mismatched unrelated donors, after conditioning with 2 Gy total body irradiation (TBI) and fludarabine. The primary endpoint was safety, defined as a 100-day incidence of nonrelapse mortality (NRM) <35%. One patient had primary graft rejection, whereas the remaining 19 patients had sustained engraftment. The 100-day cumulative incidence of grade II-IV acute GVHD (aGVHD) was 35%, whereas 65% of the patients experienced moderate/severe chronic GVHD (cGVHD). One-year NRM (10%), relapse (30%), overall survival (OS) (80%) and progression-free survival (PFS) (60%), and 1-year incidence of death from GVHD or infection with GVHD (10%) were encouraging. These figures compare favorably with those observed in a historic group of 16 patients given HLA-mismatched PBSCs (but no MSCs) after NMA conditioning, which had a 1-year incidence of NRM of 37% (P = .02), a 1-year incidence of relapse of 25% (NS), a 1-year OS and PFS of 44% (P = .02), and 38% (P = .1), respectively, and a 1-year rate of death from GVHD or infection with GVHD of 31% (P = .04). In conclusion, our data suggest that HLA-mismatched NMA HCT with MSC coinfusion appeared to be safe. [less ▲]

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See detailMars ultraviolet dayglow variability: SPICAM observations and comparison with airglow model
Cox, Cédric ULg; Gérard, Jean-Claude ULg; Hubert, Benoît ULg et al

in Journal of Geophysical Research. Planets (2010), 115

Dayglow ultraviolet emissions of the CO Cameron bands and the CO[SUB]2[/SUB][SUP]+[/SUP] doublet in the Martian atmosphere have been observed with the Spectroscopy for Investigation of Characteristics of ... [more ▼]

Dayglow ultraviolet emissions of the CO Cameron bands and the CO[SUB]2[/SUB][SUP]+[/SUP] doublet in the Martian atmosphere have been observed with the Spectroscopy for Investigation of Characteristics of the Atmosphere of Mars on board the Mars Express spacecraft. A large amount of limb profiles has been obtained which makes it possible to analyze variability of the brightness as well as of the altitude of the emission peak. Focusing on one specific season (Ls = [90,180] °), we find that the average CO peak brightness is equal to 118 ± 33 kR, with an average peak altitude of 121.1 ± 6.5 km. Similarly, the CO[SUB]2[/SUB][SUP]+[/SUP] emission shows a mean brightness of 21.6 ± 7.2 kR with a peak located at 119.1 ± 7.0 km. We show that the brightness intensity of the airglows is mainly controlled by the solar zenith angle and by solar activity. Moreover, during Martian summer of year 2005, an increase of the airglow peak altitude has been observed between Ls = 120° and 180°. We demonstrate that this variation is due to a change in the thermospheric local CO[SUB]2[/SUB] density, in agreement with observations performed by stellar occultation. Using a Monte Carlo one-dimensional model, we also show that the main features of the emission profiles can be reproduced for the considered set of data. However, we find it necessary to scale the calculated intensities by a fixed factor. [less ▲]

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See detailA survey of honey bee colony losses in Belgium, fall 2008 to spring 2009
Nguyen, Bach Kim ULg; Mignon, Jacques ULg; Laget, D. et al

Conference (2010)

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See detailA hybrid model for the simulation of angiogenesis during bone fracture healing
Geris, Liesbet ULg; Peiffer, Veronique; Gerisch, Alf et al

in Proceedings of the 17th conference of the European Society of Biomechanics (2010)

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See detailApproche multirisque du patient diabetique de type 2: desaccord sur les valeurs cibles suite a l'etude ACCORD.
Scheen, André ULg; Paquot, Nicolas ULg

in Revue Médicale Suisse (2010), 6(260), 1582-7

The ACCORD trial investigated the effects of intensifying the global management of 10,251 type 2 diabetic patients, with established cardiovascular disease or at least two other cardiovascular risk ... [more ▼]

The ACCORD trial investigated the effects of intensifying the global management of 10,251 type 2 diabetic patients, with established cardiovascular disease or at least two other cardiovascular risk factors, on a composite endpoint (non fatal myocardial infarction, stroke and cardiovascular death). The attempt to reduce HbA1c level below 6% was associated with an increased cardiovascular mortality (despite a reduction in non fatal myocardial infarcts); lowering systolic blood pressure below 120 mmHg instead of 140 mmHg did not provide any additional benefit; finally, the control of atherogenic dyslipidaemia, with fenofibrate added to a statin, did not modify the composite endpoint (despite a positive effect in the subgroup of patients with high triglycerides and low HDL cholesterol). These rather disappointing results should be interpreted to provide practical guidelines. [less ▲]

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See detailIII-V Devices for Advanced CMOS
Waldron, Niamh; Nguyen, Ngoc Duy ULg; Lin, Dennis et al

in 217th ECS Meeting (2010)

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See detailLe cycle de Guillaume d’Orange ou les Aliscans rajeunis
Henrard, Nadine ULg

in Cazanave, Caroline; Houssais, Yvon (Eds.) Grands textes du Moyen Âge à l'usage des petits (2010)

Examen d'une douzaine de versions de récritures de la geste de Guillaume d'Orange parues entre 1905 et 1995 et destinées à la jeunesse

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