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See detailIntérêt du dosage des sulfamidés hypoglycémiants: de la vérification de la compliance au diagnostic différentiel des hyperinsulinismes
Denooz, Raphael ULg; Charlier, Corinne ULg

in Revue Médicale de Liège (2010), 65(9), 493-497

Plus de cinquante ans après leur mise sur le marché, les sulfamidés hypoglycémiants font toujours partie du traitement de base du diabète non insulinodépendant. A côté de leurs remarquables propriétés ... [more ▼]

Plus de cinquante ans après leur mise sur le marché, les sulfamidés hypoglycémiants font toujours partie du traitement de base du diabète non insulinodépendant. A côté de leurs remarquables propriétés pharmacologiques, ces produits ont, à différentes reprises, été tenus responsables d’hypoglycémies sévères survenant de manière inexpliquée chez des sujets non diabétiques. Ce type d’hypoglycémie, qualifiée de factice, est notamment fréquemment retrouvée dans le syndrome de Munchausen, trouble psychiatrique poussant le malade à mimer une pathologie. Cette hypoglycémie est associée à un hyperinsulinisme endogène simulant une pathologie endocrine très rare, l’insulinome. Nous souhaitons faire connaître aux Cliniciens l’intérêt de la recherche et du dosage sanguin des sulfamidés hypoglycémiants dans le cadre du diagnostic différentiel des hyperinsulinismes. La mise en évidence d’une hypoglycémie induite par ces médicaments constitue un élément intéressant pour orienter le diagnostic et éventuellement éviter une pancréatectomie en cas de forte suspicion d’insulinome. La méthode analytique développée au laboratoire s’appuie sur la chromatographie liquide ultra performante couplée à la spectrométrie de masse tandem (UPLC -MS -MS ). Par cette technique, on peut mettre en évidence dans le sang une dizaine de sulfonylurées et le répaglinide. Elle constituera à l’avenir une méthode de choix face à toute suspicion de mésusage des sulfonylurées. [less ▲]

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See detailHigh Levels of 18F-FDG Uptake in Aortic Aneurysm Wall are Associated with High Wall Stress
Xu, Yun; Borghi, Alexandre; NCHIMI LONGANG, Alain ULg et al

in European Journal of Vascular and Endovascular Surgery (2010), 39

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See detailAnalysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk
Mahachie John, Jestinah ULg; Baurecht, H.; Rodriguez, E. et al

in Allergy (2010), 65(7), 875-882

To cite this article: Mahachie John JM, Baurecht H, Rodriguez E, Naumann A, Wagenpfeil S, Klopp N, Mempel M, Novak N, Bieber T, Wichmann H-E, Ring J, Illig T, Cattaert T, Van Steen K, Weidinger S ... [more ▼]

To cite this article: Mahachie John JM, Baurecht H, Rodriguez E, Naumann A, Wagenpfeil S, Klopp N, Mempel M, Novak N, Bieber T, Wichmann H-E, Ring J, Illig T, Cattaert T, Van Steen K, Weidinger S. Analysis of the high-affinity IgE receptor genes reveals epistatic effects of FCER1A variants on total IgE levels and eczema risk. Allergy 2009; DOI: 10.1111/j.1398-9995.2009.02297.x. Abstract Background: High levels of total and allergen-specific IgE levels are a key feature in allergic diseases. The high-affinity receptor for IgE, which is composed of one alpha (FCER1A), one beta (FCER1B), and two gamma (FCER1G) subunits, represents the central receptor of IgE-induced reactions. In a genome-wide association scan, we recently identified associations between functional FCER1A variants and total serum IgE levels. Previous studies had reported linkage and association of FCER1B variants with IgE and atopic traits. The FCER1G gene has not yet been investigated with regard to atopy. Filaggrin (FLG) is the strongest known risk gene for eczema, in particular the allergic subtype of eczema. Methods: We investigated the association of FCER1A, FCER1B, and FCER1G variants with IgE in a large population-based cohort (n = 4261) and tested for epistatic effects using the model-based multifactor dimensionality reduction (MB-MDR) method. In addition, we investigated a potential interaction between FLG and FCER1A variants in a large collection of eczema cases (n = 1018) and population controls. Results: Three strongly correlated FCER1A polymorphisms were significantly associated with total and specific IgE levels as well as allergic sensitization. No associations were seen for FCER1B and FCER1G. After adjustment for FLG effects, a significant epistatic effect of the FCER1A variants rs10489854 and rs2511211 on eczema risk was detected. Conclusions: These results suggest that FCER1A variants by themselves and in combination influence IgE levels and act synergistically to influence eczema risk. [less ▲]

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See detailRecognition and validation of non-formal and informal learning in French-speaking Belgium. Discourse and practices
Peters, Stéphanie ULg; Mahieu, Céline; Salmon, Arnaud et al

in Lifelong Learning in Europe (2010), 15(2), 119-128

The validation of formal and informal learning has been practiced in French-speaking Belgium for several years, via the mechanisms known as Recognition of Non-Formal and Informal Learning (RNF-IFL) and ... [more ▼]

The validation of formal and informal learning has been practiced in French-speaking Belgium for several years, via the mechanisms known as Recognition of Non-Formal and Informal Learning (RNF-IFL) and Accreditation of Prior Experiential Learning (APEL). These credits contribute in the fullest way possible to the political project for the development of society based on knowledge and lifelong learning. Actors involved in the validation process must deal with a more and more fragmented knowledge. Further, the abovementioned mechanisms of validation are related to many questions, involving identity, methodology, and strategic and sociopolitical matters, all of which are touched upon in the present article. [less ▲]

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See detailManagement effects on European cropland respiration
Eugster, W.; Moffat, A. M.; Ceschia, E. et al

in Agriculture, Ecosystems & Environment (2010), 139

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See detailThermodynamic analysis of the interaction of surfactin, a bacterial lipopeptide, to lipid vesicles
Deleu, Magali ULg

in 13th International Conference on organized molecular films (2010)

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See detailIII-V Devices for Advanced CMOS
Waldron, Niamh; Nguyen, Ngoc Duy ULg; Lin, Dennis et al

in 217th ECS Meeting (2010)

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See detailExamen de jurisprudence récente en matière de règlement collectif de dettes
Grella, Vanessa ULg; Fry, Ariane

in J. CLESSE et M. DUMONT (Ed.) Actualités de droit social - CUP (2010)

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See detailExperimental investigation of the effect of flip bucket splitters on plunge pool geometry
Erpicum, Sébastien ULg; Archambeau, Pierre ULg; Dewals, Benjamin ULg et al

in Wasserwirtschaft (2010), 4

Flip buckets are common hydraulic structures aiming at deflecting high velocity flows to a free jet trajectory. Systematic experimental tests have been performed to assess the influence on energy ... [more ▼]

Flip buckets are common hydraulic structures aiming at deflecting high velocity flows to a free jet trajectory. Systematic experimental tests have been performed to assess the influence on energy dissipation and the plunge pool geometry of varied repartitions of splitters along the flip bucket width. In particular, it is shown that some configurations can create more erosion than a continuous channel without flip bucket. [less ▲]

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See detailSpatial variability of the Siphonophora along the radial Calvi-Nice (Corsican side)
Collignon, Amandine ULg; Hecq, Jean-Henri ULg; Goffart, Anne ULg

Poster (2010)

The spatial distribution of the Siphonophorae has been examined, in Occidental Mediterranean, along the radial Calvi-Nice, from Calvi up to 30 miles offshore in September 2009. The variation of the ... [more ▼]

The spatial distribution of the Siphonophorae has been examined, in Occidental Mediterranean, along the radial Calvi-Nice, from Calvi up to 30 miles offshore in September 2009. The variation of the abundance of the plankton and of the Siphonophorae was put in relation with the hydrological structures of the Liguro-Provençal front. This structure separates the coastal waters of Atlantic origin from the offshore central Mediterranean waters of deep origin. Globally, the larger abundances of Siphonophorae were present in inshore waters between the front and the coast. Both nectophores (asexual stage) and gonophores and bracts (reproductive stage) of Lensia subtilis occured only in the inshore waters. The nectophores of Chelophyes appendiculata occured at all sampling stations with no significative variation. However, the abundance of the bracts and the gonophores increases when we get closer to the coast. This allows us to hypothesize that the maximum of reproduction is located in waters close to the coast. On the other hand, the larvae abundance of calycophoran siphonophores, in the plankton samples, increase from the coastal waters to the offshore waters with a maximum of abundance at the station located at 25 miles offshore. That contradiction could be explained by plankton net avoidance of small larvae, by current transport or by variable hatching success at the various stations. The larvae of physonect siphonophores are more often found offshore. [less ▲]

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See detailPneumoinie à pseudomonas aeruginosa chez le python indien
Gandar; Szalo; Etienne et al

in Monde Vétérinaire (Le) : European Veterinary Magazine (2010), 107

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See detailMolecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation.
Yevenes, Gonzalo E; Moraga-Cid, Gustavo; Avila, Ariel et al

in Journal of Biological Chemistry (2010), 285(39), 30203-13

It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure. Thus, the differential ethanol ... [more ▼]

It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure. Thus, the differential ethanol sensitivity of diverse GlyR isoforms and mutants was explained by the presence of specific residues in putative alcohol pockets. Here, we demonstrate that ethanol sensitivity in two ligand-gated ion receptor members, the GlyR adult alpha(1) and embryonic alpha(2) subunits, can be modified through selective mutations that rescued or impaired Gbetagamma modulation. Even though both isoforms were able to physically interact with Gbetagamma, only the alpha(1) GlyR was functionally modulated by Gbetagamma and pharmacological ethanol concentrations. Remarkably, the simultaneous switching of two transmembrane and a single extracellular residue in alpha(2) GlyRs was enough to generate GlyRs modulated by Gbetagamma and low ethanol concentrations. Interestingly, although we found that these TM residues were different to those in the alcohol binding site, the extracellular residue was recently implicated in conformational changes important to generate a pre-open-activated state that precedes ion channel gating. Thus, these results support the idea that the differential ethanol sensitivity of these two GlyR isoforms rests on conformational changes in transmembrane and extracellular residues within the ion channel structure rather than in differences in alcohol binding pockets. Our results describe the molecular basis for the differential ethanol sensitivity of two ligand-gated ion receptor members based on selective Gbetagamma modulation and provide a new mechanistic framework for allosteric modulations of abuse drugs. [less ▲]

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See detailHistory effect of light and temperature on monoterpenoid emissions from Fagus sylvatica L.
Demarcke, M.; Schoon, N.; Van Langenhove, H. et al

in Atmospheric Environment (2010), 44(27), 3261-3268

Monoterpenoid emissions from Fagus sylvatica L trees have been measured at light- and temperature-controlled conditions in a growth chamber, using Proton Transfer Reaction Mass Spectrometry (PTR-MS) and ... [more ▼]

Monoterpenoid emissions from Fagus sylvatica L trees have been measured at light- and temperature-controlled conditions in a growth chamber, using Proton Transfer Reaction Mass Spectrometry (PTR-MS) and the dynamic branch enclosure technique. De novo synthesized monoterpenoid Standard Emission Factors, obtained by applying the G97 algorithm (Guenther, 1997), varied between 2 and 32 mu g g(-1)DW h(-1) and showed a strong decline in late August and September, probably due to senescence. The response of monoterpenoid emissions to temperature variations at a constant daily light pattern could be well reproduced with a modified version of the MEGAN algorithm (Guenther et al., 2006), with a typical dependence on the average temperature over the past five days. The diurnal emissions at constant temperature showed a typical hysteretic behaviour, which could also be adequately described with the modified MEGAN algorithm by taking into account a dependence on the average light levels experienced by the trees during the past 10-13 h. The impact of the past light and temperature conditions on the monoterpenoid emissions from E sylvatica L was found to be much stronger than assumed in previous algorithms. Since our experiments were conducted under low light intensity, future studies should aim at confirming and completing the proposed algorithm updates in sunny conditions and natural environments. (C) 2010 Elsevier Ltd. All rights reserved. [less ▲]

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See detailMarker imputation with low-density marker panels in Dutch Holstein cattle.
Zhang, Zhiyan; Druet, Tom ULg

in Journal of Dairy Science (2010), 93(11), 5487-94

The availability of high-density bovine genotyping arrays made implementation of genomic selection possible in dairy cattle. Development of low-density single nucleotide polymorphism (SNP) panels will ... [more ▼]

The availability of high-density bovine genotyping arrays made implementation of genomic selection possible in dairy cattle. Development of low-density single nucleotide polymorphism (SNP) panels will allow the extension of genomic selection to a larger portion of the population. Prediction of ungenotyped markers, called imputation, is a strategy that allows using the same low-density chips for all traits (and for different breeds). In the present study, we evaluated the accuracy of imputation with low-density genotyping arrays in the Dutch Holstein population. Five different sizes of genotyping arrays were tested, from 384 to 6,000 SNP. According to marker density, the overall allelic imputation error rate obtained with the program DAGPHASE, which relies on linkage disequilibrium and linkage, ranged from 11.7 to 2.0%, and that obtained with the program CHROMIBD, which relies on linkage and the set of all genotyped ancestors, ranged from 10.7 to 3.3%. However, imputation efficiency was influenced by the relationship between low-density and high-density genotyped animals. Animals with both parents genotyped had particularly low imputation error rates: <1% with 1,500 SNP or more. In summary, missing marker alleles can be predicted with 3 to 4% errors with approximately 1 SNP/Mb (approximately 3,000 markers). The CHROMIBD program proved more efficient than DAGPHASE only at lower marker densities or when several genotyped ancestors were available. Future studies are required to measure the effect of these imputation error rates on accuracy of genomic selection with low-density SNP panels. [less ▲]

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See detailComics, Trauma, and Cultural Memory(ies) of 9/11
Dony, Christophe ULg; Van Linthout, Caroline ULg

in Goggin, Joyce; Hassler-Forest, Dan (Eds.) The Rise and Reason of Comics and Graphic Literature: Critical Essays on the Form (2010)

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See detailExperimental and theoretical lifetimes and transition probabilities in Sb I
Hartman, H; Nilsson, H; Engström, L et al

in Physical Review. A (2010), 82