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See detailGrands ou petits attentats ? Mesure de l’impact des réformes orthographiques sur la physionomie des textes
Dister, Anne; Purnelle, Gérald ULg; Beaufort, Richard

in Bolasco, Sergio (Ed.) Proceedings of the JADT 2010, 10th International Conference on the Statistical Analysis of Textual Data, Rome, 9-11 June 2010 (2010)

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See detailAnticipatory Artificial Autopoiesis
Dubois, Daniel ULg; Holmberg, Stig C.

in Trappl, Robert (Ed.) CYBERNETICS AND SYSTEMS 2010 (2010)

In examining relationships between autopoiesis and anticipation in artificial life (Alife) systems it is demonstrated that anticipation may increase efficiency and viability in artificial autopoietic ... [more ▼]

In examining relationships between autopoiesis and anticipation in artificial life (Alife) systems it is demonstrated that anticipation may increase efficiency and viability in artificial autopoietic living systems. This paper, firstly, gives a review of the Varela et al [1974] automata algorithm of an autopoietic living cell. Some problems in this algorithm must be corrected. Secondly, a new and original anticipatory artificial autopoiesis algorithm for automata is presented. In our automata system, the asymmetric membrane of the self-creating living cell plays a central role. The simulation confirms the validity of our algorithm in showing its autopoietic properties. [less ▲]

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See detailL’édition pour la jeunesse en Belgique francophone : de la nécessité faite vertu à la mondialisation
Habrand, Tanguy ULg

in Pinhas, Luc; Foucault, Jean; Manson, Michel (Eds.) L'édition de jeunesse francophone face à la mondialisation (2010)

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See detailCotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning.
Baron, Frédéric ULg; Lechanteur, Chantal ULg; Willems, Evelyne ULg et al

in Biology of Blood & Marrow Transplantation (2010), 16(6), 838-47

Recent studies have suggested that coinfusion of mesenchymal stem cells (MSCs) the day of hematopoietic cell transplantation (HCT) might promote engraftment and prevent graft-versus-host disease (GVHD ... [more ▼]

Recent studies have suggested that coinfusion of mesenchymal stem cells (MSCs) the day of hematopoietic cell transplantation (HCT) might promote engraftment and prevent graft-versus-host disease (GVHD) after myeloablative allogeneic HCT. This prompted us to investigate in a pilot study whether MSC infusion before HCT could allow nonmyeloablative (NMA) HCT (a transplant strategy based nearly exclusively on graft-versus-tumor effects for tumor eradication) from HLA-mismatched donors to be performed safely. Twenty patients with hematologic malignancies were given MSCs from third party unrelated donors 30-120 minutes before peripheral blood stem cells (PBSCs) from HLA-mismatched unrelated donors, after conditioning with 2 Gy total body irradiation (TBI) and fludarabine. The primary endpoint was safety, defined as a 100-day incidence of nonrelapse mortality (NRM) <35%. One patient had primary graft rejection, whereas the remaining 19 patients had sustained engraftment. The 100-day cumulative incidence of grade II-IV acute GVHD (aGVHD) was 35%, whereas 65% of the patients experienced moderate/severe chronic GVHD (cGVHD). One-year NRM (10%), relapse (30%), overall survival (OS) (80%) and progression-free survival (PFS) (60%), and 1-year incidence of death from GVHD or infection with GVHD (10%) were encouraging. These figures compare favorably with those observed in a historic group of 16 patients given HLA-mismatched PBSCs (but no MSCs) after NMA conditioning, which had a 1-year incidence of NRM of 37% (P = .02), a 1-year incidence of relapse of 25% (NS), a 1-year OS and PFS of 44% (P = .02), and 38% (P = .1), respectively, and a 1-year rate of death from GVHD or infection with GVHD of 31% (P = .04). In conclusion, our data suggest that HLA-mismatched NMA HCT with MSC coinfusion appeared to be safe. [less ▲]

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See detailSelective osteopontin knockdown exerts anti-tumoral activity in a human glioblastoma model.
Lamour, Virginie ULg; Le Mercier, M.; Lefranc, F. et al

in International Journal of Cancer = Journal International du Cancer (2010), 126

Osteopontin (OPN), a member of the SIBLING (Small Integrin-Binding LIgand N-linked Glycoprotein) family, is overexpressed in human glioblastoma. Higher levels of OPN expression correlate with increased ... [more ▼]

Osteopontin (OPN), a member of the SIBLING (Small Integrin-Binding LIgand N-linked Glycoprotein) family, is overexpressed in human glioblastoma. Higher levels of OPN expression correlate with increased tumor grade and enhanced migratory capacity of tumor cells. Based on these observations, we explored the possibility that knocking down OPN expression in glioblastoma cells could exert an anti-tumoral activity using an avian in vivo glioblastoma model that mimics closely human gliobastoma. Human U87-MG glioma cells transfected with specific anti-OPN small interfering RNAs (siRNAs) were grafted onto the chicken chorio-allantoic membrane (CAM). OPN-deficient U87-MG cells gave rise to tumors that were significantly smaller than tumors formed from untransfected cells (paired t-test, p<0.05). Accordingly, the amount of proliferating cells in OPN-deficient tumors showed a six-fold reduction when compared to control tumors. However, OPN inhibition did not affect significantly tumor-associated angiogenesis. In vitro, OPN-silenced U87-MG and U373-MG cells showed decreased motility and migration. This is the first demonstration that OPN inhibition blocks glioma tumor growth, making this invasion-related protein an attractive target for glioma therapy. (c) 2009 UICC. [less ▲]

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See detailA survey of honey bee colony losses in Belgium, fall 2008 to spring 2009
Nguyen, Bach Kim ULg; Mignon, Jacques ULg; Laget, D. et al

Conference (2010)

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See detailIII-V Devices for Advanced CMOS
Waldron, Niamh; Nguyen, Ngoc Duy ULg; Lin, Dennis et al

in 217th ECS Meeting (2010)

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See detailVertical distribution of ammonia-oxidizing crenarchaeota and methanogens in the epipelagic waters of Lake Kivu (Rwanda-Democratic Republic of the Congo)
Llirós, M.; Gich, F.; Plasencia, A. et al

in Applied and Environmental Microbiology (2010), 76(20), 6853-6863

Four stratified basins in Lake Kivu (Rwanda-Democratic Republic of theCongo) were sampled in March 2007 to investigate the abundance,distribution, and potential biogeochemical role of planktonic archaea ... [more ▼]

Four stratified basins in Lake Kivu (Rwanda-Democratic Republic of theCongo) were sampled in March 2007 to investigate the abundance,distribution, and potential biogeochemical role of planktonic archaea. We used fluorescence in situ hybridization with catalyzed-reported deposition microscopic counts (CARD-FISH), denaturing gradient gel electrophoresis (DGGE) fingerprinting, and quantitative PCR (qPCR) of signature genes for ammonia-oxidizingarchaea (16S rRNA for marine Crenarchaeota group 1.1a [MCG1] and ammonia monooxygenase subunit A [amoA]). Abundance of archaea ranged from 1 to 4.5% of total DAPI (4'6- diamidino-2-phenylindole) counts with maximal concentrations at theoxic-anoxic transition zone (∼50-m depth). Phylogenetic analysis of the archaeal planktonic community revealed a higher level of richnessof crenarchaeal 16S rRNA gene sequences (21 of the 28 operational taxonomic units [OTUs] identified [75%]) over euryarchaeotal ones (7 OTUs). Sequences affiliated with the kingdom Euryarchaeota were mainly recovered from the anoxic water compartment and mostly grouped into methanogenic lineages (Methanosarcinales and Methanocellales). In turn, crenarchaeal phylotypes were recovered throughout the sampled epipelagic waters (0- to 100-m depth), with clear phylogenetic segregation along the transition from oxic to anoxic water masses. Thus, whereas in the anoxic hypolimnion crenarchaeotal OTUs were mainly assigned to the miscellaneous crenarchaeotic group, the OTUs from the oxic-anoxic transition and above belonged to Crenarchaeota groups 1.1a and 1.1b, two lineages containing most of the ammonia-oxidizing representatives known so far. The concomitant vertical distribution of both nitrite and nitrate maxima and the copy numbers of both MCG1 16S rRNA and amoA genes suggest the potential implication of Crenarchaeota in nitrification processes occurring in the epilimnetic waters of the lake. © 2010, American Society for Microbiology. [less ▲]

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See detailCentral exclusive production: Vector mesons, dijets, Higgs boson
Cudell, Jean-René ULg

(2010)

I review the situation of theoretical predictions of central exclusive production, and show that the CDF dijet data can be used to constrain the prediction of central exclusive Higgs boson production. I ... [more ▼]

I review the situation of theoretical predictions of central exclusive production, and show that the CDF dijet data can be used to constrain the prediction of central exclusive Higgs boson production. I also show that central exclusive production might be used as a discovery tool for the odderon. [less ▲]

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See detailLe cycle de Guillaume d’Orange ou les Aliscans rajeunis
Henrard, Nadine ULg

in Cazanave, Caroline; Houssais, Yvon (Eds.) Grands textes du Moyen Âge à l'usage des petits (2010)

Examen d'une douzaine de versions de récritures de la geste de Guillaume d'Orange parues entre 1905 et 1995 et destinées à la jeunesse

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See detailThe nucleolus: structure/function relationship in RNA metabolism.
Hernandez-Verdun, Daniele; Roussel, Pascal; Thiry, Marc ULg et al

in Wiley Interdisciplinary Reviews. RNA (2010), 1(3), 415-31

The nucleolus is the ribosome factory of the cells. This is the nuclear domain where ribosomal RNAs are synthesized, processed, and assembled with ribosomal proteins. Here we describe the classical ... [more ▼]

The nucleolus is the ribosome factory of the cells. This is the nuclear domain where ribosomal RNAs are synthesized, processed, and assembled with ribosomal proteins. Here we describe the classical tripartite organization of the nucleolus in mammals, reflecting ribosomal gene transcription and pre-ribosomal RNA (pre-rRNA) processing efficiency: fibrillar center, dense fibrillar component, and granular component. We review the nucleolar organization across evolution from the bipartite organization in yeast to the tripartite organization in humans. We discuss the basic principles of nucleolar assembly and nucleolar structure/function relationship in RNA metabolism. The control of nucleolar assembly is presented as well as the role of pre-existing machineries and pre-rRNAs inherited from the previous cell cycle. In addition, nucleoli carry many essential extra ribosomal functions and are closely linked to cellular homeostasis and human health. The last part of this review presents recent advances in nucleolar dysfunctions in human pathology such as cancer and virus infections that modify the nucleolar organization. [less ▲]

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See detailA new type of cubic-stacked layer structure in anthoinite, AlWO3(OH3)
Grey, I.; Madsen, I.; Mills et al

in American Mineralogist (2010), 95

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See detailLes nouveaux défis de l'enseignement du français langue étrangère en Europe
Defays, Jean-Marc ULg

in Dialogues et Cultures (2010), 56

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See detailMinorité et tutelle
Deguel, François ULg

in Leleu, Yves-Henri (Ed.) Chroniques notariales (2010)

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See detailOperational multipartite entanglement classes for symmetric photonic qubit states
Kiesel, N.; Wieczorek, W.; Krins, Stéphanie ULg et al

Poster (2010)

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See detailBPCO et inflammation: mise au point d'un groupe d'experts. Les mecanismes de l'inflammation et du remodelage.
Aubier, M.; Marthan, R.; Berger, P. et al

in Revue des Maladies Respiratoires (2010), 27(10), 1254-1266

The present study reviews the literature on inflammation and remodelling mechanisms in chronic obstructive pulmonary disease (COPD). The development of COPD is associated with chronic pulmonary ... [more ▼]

The present study reviews the literature on inflammation and remodelling mechanisms in chronic obstructive pulmonary disease (COPD). The development of COPD is associated with chronic pulmonary inflammation. Immunity (innate or adaptive) plays a role in its onset and continuation. Airways inflammation alters bronchial structure/function relations: increased bronchial wall thickness, increased bronchial smooth muscle tone, seromucosal gland hypersecretion and loss of elastic structures. Circulating markers of pulmonary inflammation indicate its systemic dissemination. Oxidative stress plays a major role in the onset and persistence of tissue abnormalities. The determinants of extra- and intra-cellular redox control are only partially known. Susceptibility genes, antioxidant system insufficiency and reduced levels of anti-age molecules and of histone deacetylation are also involved. The molecular and cellular targets of inflammation and remodelling are numerous and complex. Currently, tools exist to limit inflammation in COPD but not to act on structural remodelling. [less ▲]

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See detailDroits de l'homme et "choc des civilisations"
Delruelle, Edouard ULg

in Revue Trimestrielle des Droits de l'Homme [= RTDH] (2010)

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