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See detailInertie et observance therapeutiques en tant que facteurs influencant le controle de l'asthme.
Louis, Renaud ULg; Manise, Maïté ULg; Sele, Jocelyne ULg et al

in Revue Médicale de Liège (2010), 65(5-6), 338-42

Asthma is a chronic inflammatory disease which can be most often adequately controlled by current medications as demonstrated by multiple randomised clinical trials. Yet most of the recent surveys ... [more ▼]

Asthma is a chronic inflammatory disease which can be most often adequately controlled by current medications as demonstrated by multiple randomised clinical trials. Yet most of the recent surveys conducted in the real life setting point to an inadequate control in the majority of asthmatics. In addition to factors linked to the hygiene of life, clinician's inertia and patient's lack of adherence to the treatment certainly contribute to poor asthma control. [less ▲]

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See detailAnalysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk
Mahachie John, Jestinah ULg; Baurecht, H.; Rodriguez, E. et al

in Allergy (2010), 65(7), 875-882

To cite this article: Mahachie John JM, Baurecht H, Rodriguez E, Naumann A, Wagenpfeil S, Klopp N, Mempel M, Novak N, Bieber T, Wichmann H-E, Ring J, Illig T, Cattaert T, Van Steen K, Weidinger S ... [more ▼]

To cite this article: Mahachie John JM, Baurecht H, Rodriguez E, Naumann A, Wagenpfeil S, Klopp N, Mempel M, Novak N, Bieber T, Wichmann H-E, Ring J, Illig T, Cattaert T, Van Steen K, Weidinger S. Analysis of the high-affinity IgE receptor genes reveals epistatic effects of FCER1A variants on total IgE levels and eczema risk. Allergy 2009; DOI: 10.1111/j.1398-9995.2009.02297.x. Abstract Background: High levels of total and allergen-specific IgE levels are a key feature in allergic diseases. The high-affinity receptor for IgE, which is composed of one alpha (FCER1A), one beta (FCER1B), and two gamma (FCER1G) subunits, represents the central receptor of IgE-induced reactions. In a genome-wide association scan, we recently identified associations between functional FCER1A variants and total serum IgE levels. Previous studies had reported linkage and association of FCER1B variants with IgE and atopic traits. The FCER1G gene has not yet been investigated with regard to atopy. Filaggrin (FLG) is the strongest known risk gene for eczema, in particular the allergic subtype of eczema. Methods: We investigated the association of FCER1A, FCER1B, and FCER1G variants with IgE in a large population-based cohort (n = 4261) and tested for epistatic effects using the model-based multifactor dimensionality reduction (MB-MDR) method. In addition, we investigated a potential interaction between FLG and FCER1A variants in a large collection of eczema cases (n = 1018) and population controls. Results: Three strongly correlated FCER1A polymorphisms were significantly associated with total and specific IgE levels as well as allergic sensitization. No associations were seen for FCER1B and FCER1G. After adjustment for FLG effects, a significant epistatic effect of the FCER1A variants rs10489854 and rs2511211 on eczema risk was detected. Conclusions: These results suggest that FCER1A variants by themselves and in combination influence IgE levels and act synergistically to influence eczema risk. [less ▲]

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See detailSignspeak--understanding, recognition, and translation of sign languages
Dreuw, Philippe; Forster, Jens; Gweth, Yannick et al

in 4th Workshop on the Representation and Processing of Sign Languages: Corpora and Sign Language Technologies (2010)

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See detailLes donations d'entreprises en region de Bruxelles-capitale
Douny, Raphaël ULg

in Manuel de planification patrimoniale (2010)

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See detailOn a class of micromechanical damage models with initial stresses for geomaterials
Levasseur, Séverine ULg; Collin, Frédéric ULg; Charlier, Robert ULg et al

in Mechanics Research Communications (2010), 37

In this paper, we extend a class of micromechanical damage models by including initial stresses. The proposed approach is based on the solution of the Eshelby inhomogeneous inclusion problem in the ... [more ▼]

In this paper, we extend a class of micromechanical damage models by including initial stresses. The proposed approach is based on the solution of the Eshelby inhomogeneous inclusion problem in the presence of a prestress (in the matrix), adapted for elastic voided media. The closed form expression of the corresponding energy potential is used as the basis of various isotropic damage models corresponding to three standard homogenization schemes. These models are illustrated by considering isotropic tensile loadings with different initial stresses. Finally, still in the isotropic context, we provide an interpretation of the macroscopic damage model formulated by Halm-Dragon (1996) by briefly connecting it to the present study. [less ▲]

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See detailHydro-mechanical modelling of the Excavation Damaged Zone around an underground excavation at Mont Terri Rock Laboratory
Levasseur, Séverine ULg; Charlier, Robert ULg; Frieg, Bernd et al

in International Journal of Rock Mechanics & Mining Sciences (2010), 47(3), 414-425

A zone with significant irreversible deformations and significant changes in flow and transport properties is expected to be formed in indurated clay around underground excavations. The stress ... [more ▼]

A zone with significant irreversible deformations and significant changes in flow and transport properties is expected to be formed in indurated clay around underground excavations. The stress perturbation around the excavation could lead to a significant increase of the permeability, related to diffuse and/or localized crack propagation in the material. The main objective of the study is to model these processes at large scale in order to assess their impacts on the performance of radioactive waste geological repositories. This paper concerns more particularly the hydro-mechanical modelling of a long term dilatometer experiment performed in Mont Terri Rock Laboratory in Switzerland within the Selfrac Project. The proposed model defines the permeability as a function of the aperture of the cracks that are generated during the excavation. With this model, the permeability tensor becomes anisotropic. Advantages and drawbacks of this approach are described thanks to the results of the Selfrac long term dilatometer experiment. [less ▲]

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See detailLes donations d'entreprises en region wallonne
Douny, Raphaël ULg

in Manuel de planification patrimoniale (2010)

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See detailBrainstem specific warping improves locus coeruleus functional imaging in humans
Balteau, Evelyne ULg; Schmidt, Christina ULg; Maquet, Pierre ULg et al

in Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society For Magnetic Resonance in Medicine. Scientific Meeting and Exhibition (2010)

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See detailExplicit Solution to the Full Nonlinear Problem for Satellite Formation-keeping
Cho, Hancheol ULg; Udwadia, Firdaus

in Acta Astronautica (2010), 67(3-4), 369-387

This paper presents simple and exact formation-keeping guidance schemes that use a new method that is rooted in some recent advances in analytical dynamics. As a result of this new approach, explicit ... [more ▼]

This paper presents simple and exact formation-keeping guidance schemes that use a new method that is rooted in some recent advances in analytical dynamics. As a result of this new approach, explicit control inputs to exactly maintain a given formation configuration are easily determined using continuous thrust propulsion systems. The complete nonlinear problem is addressed, and no linearizations and/or approximations are made. The approach provides a marked improvement over existing results in that the control forces, which cause geometric formation-keeping constraints to be exactly satisfied for arbitrary reference orbits, are found in closed form. For Keplerian reference orbits, a much simpler and explicit expression for the control needed to exactly satisfy formation-keeping constraints than hereto available is obtained. The paper also includes explicit control results when the follower is inserted into orbit with incorrect initial conditions, as usually happens in practice. The Hill reference frame, which is often more intuitive for formation-keeping, is used in the analysis. While this paper takes an example of a projected circular formation, the methodology that is developed can be applied to any desired configuration or orbital requirements. Extensive computational simulations are performed to demonstrate the ease of implementation, and the numerical accuracy provided by the approach developed herein. [less ▲]

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See detailThe California Verbal Learning Test and other standard clinical neuropsychological tests to predict conversion from mild memory impairment to dementia.
Lekeu, Françoise ULg; Magis, Delphine ULg; Marique, Patricia et al

in Journal of Clinical and Experimental Neuropsychology (2010), 20

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See detailMechanisms for nonrecurrent genomic rearrangements associated with CMT1A or HNPP: rare CNVs as a cause for missing heritability.
Zhang, Feng; Seeman, Pavel; Liu, Pengfei et al

in American Journal of Human Genetics (2010), 86(6), 892-903

Genomic rearrangements involving the peripheral myelin protein gene (PMP22) in human chromosome 17p12 are associated with neuropathy: duplications cause Charcot-Marie-Tooth disease type 1A (CMT1A ... [more ▼]

Genomic rearrangements involving the peripheral myelin protein gene (PMP22) in human chromosome 17p12 are associated with neuropathy: duplications cause Charcot-Marie-Tooth disease type 1A (CMT1A), whereas deletions lead to hereditary neuropathy with liability to pressure palsies (HNPP). Our previous studies showed that >99% of these rearrangements are recurrent and mediated by nonallelic homologous recombination (NAHR). Rare copy number variations (CNVs) generated by nonrecurrent rearrangements also exist in 17p12, but their underlying mechanisms are not well understood. We investigated 21 subjects with rare CNVs associated with CMT1A or HNPP by oligonucleotide-based comparative genomic hybridization microarrays and breakpoint sequence analyses, and we identified 17 unique CNVs, including two genomic deletions, ten genomic duplications, two complex rearrangements, and three small exonic deletions. Each of these CNVs includes either the entire PMP22 gene, or exon(s) only, or ultraconserved potential regulatory sequences upstream of PMP22, further supporting the contention that PMP22 is the critical gene mediating the neuropathy phenotypes associated with 17p12 rearrangements. Breakpoint sequence analysis reveals that, different from the predominant NAHR mechanism in recurrent rearrangement, various molecular mechanisms, including nonhomologous end joining, Alu-Alu-mediated recombination, and replication-based mechanisms (e.g., FoSTeS and/or MMBIR), can generate nonrecurrent 17p12 rearrangements associated with neuropathy. We document a multitude of ways in which gene function can be altered by CNVs. Given the characteristics, including small size, structural complexity, and location outside of coding regions, of selected rare CNVs, their identification remains a challenge for genome analysis. Rare CNVs may potentially represent an important portion of "missing heritability" for human diseases. [less ▲]

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See detailFunctional interplay between macroH2A and Polycomb Repressive Complexes
Creppe, Catherine ULg; Valero, Vanesa; Di Croce, Luciano et al

Poster (2010)

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See detailManagement effects on net ecosystem carbon and GHG budgets at European crop sites
Ceschia, E.; Beziat, P.; Dejoux, J. F. et al

in Agriculture, Ecosystems & Environment (2010), 139

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See detailFilles et garçons face à l'orientation scientifique : stéréotypes en tout genre
Goffin, Christelle ULg; Quittre, Valérie ULg; Lafontaine, Dominique ULg

in Gavray, Claire; Adriaenssens, Alexandra (Eds.) Une fille = un garçon ? Identifier les inégalités de genre à l'école pour mieux les combattre (2010)

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See detailPhysiological constraint in host-plant specialization among specialist and generalist wild bees
Michez, Denis; Vanderplanck, Maryse ULg; Rasmont, Pierre et al

Conference (2010)

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See detailEye gaze and conscious processing in severely brain-injured patients
Chatelle, Camille ULg; Laureys, Steven ULg; Majerus, Steve ULg et al

in Behavioral and Brain Sciences (2010), 33(6), 442-443

Niedenthal et al. discuss the importance of eye gaze in embodied simulation and, more globally, in the processing of emotional visual stimulation (such as facial expression). In this commentary, we ... [more ▼]

Niedenthal et al. discuss the importance of eye gaze in embodied simulation and, more globally, in the processing of emotional visual stimulation (such as facial expression). In this commentary, we illustrate the relationship between oriented eye movements, consciousness, and emotion by using the case of severely brain-injured patients recovering from coma (i.e., vegetative and minimally conscious patients). [less ▲]

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