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See detailIschaemic mitral regurgitation: pathophysiology, outcomes and the conundrum of treatment.
PIERARD, Luc ULg; Carabello, B. A.

in European Heart Journal (2010), 31

Ischaemic mitral regurgitation is a frequent complication of left ventricular global or regional pathological remodelling due to chronic coronary artery disease. It is not a valve disease but represents ... [more ▼]

Ischaemic mitral regurgitation is a frequent complication of left ventricular global or regional pathological remodelling due to chronic coronary artery disease. It is not a valve disease but represents the valvular consequences of increased tethering forces (papillary muscles displacement leading to a more apical position of the leaflets and their coaptation point) and reduced closing forces (reduced contractility, dyssynchrony of the papillary muscles, intra-left ventricular dyssynchrony). Although mitral regurgitation has an unloading effect and reduces impedance, the volume overload begets further left ventricular dilatation, increases ventricular wall stress leading to worsened performance. Ischaemic mitral regurgitation is characteristically dynamic: its severity may vary with haemodynamic conditions. Both the severity of ischaemic mitral regurgitation and its dynamic component worsen prognosis. There are numerous possible treatment modalities, but the management of the individual patient remains difficult. Medical therapy is mandatory; revascularization procedures are frequently not sufficient to reduce mitral regurgitation; the role of combined surgical therapy by mitral valve repair is not yet defined in the absence of large randomized trial. Some patients are good candidates for cardiac resynchronization therapy that may reduce the amount of regurgitation. New therapeutic targets are under investigation. [less ▲]

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See detailBrainstem specific warping improves locus coeruleus functional imaging in humans
Balteau, Evelyne ULg; Schmidt, Christina ULg; Maquet, Pierre ULg et al

in Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society For Magnetic Resonance in Medicine. Scientific Meeting and Exhibition (2010)

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See detailExplicit Solution to the Full Nonlinear Problem for Satellite Formation-keeping
Cho, Hancheol ULg; Udwadia, Firdaus

in Acta Astronautica (2010), 67(3-4), 369-387

This paper presents simple and exact formation-keeping guidance schemes that use a new method that is rooted in some recent advances in analytical dynamics. As a result of this new approach, explicit ... [more ▼]

This paper presents simple and exact formation-keeping guidance schemes that use a new method that is rooted in some recent advances in analytical dynamics. As a result of this new approach, explicit control inputs to exactly maintain a given formation configuration are easily determined using continuous thrust propulsion systems. The complete nonlinear problem is addressed, and no linearizations and/or approximations are made. The approach provides a marked improvement over existing results in that the control forces, which cause geometric formation-keeping constraints to be exactly satisfied for arbitrary reference orbits, are found in closed form. For Keplerian reference orbits, a much simpler and explicit expression for the control needed to exactly satisfy formation-keeping constraints than hereto available is obtained. The paper also includes explicit control results when the follower is inserted into orbit with incorrect initial conditions, as usually happens in practice. The Hill reference frame, which is often more intuitive for formation-keeping, is used in the analysis. While this paper takes an example of a projected circular formation, the methodology that is developed can be applied to any desired configuration or orbital requirements. Extensive computational simulations are performed to demonstrate the ease of implementation, and the numerical accuracy provided by the approach developed herein. [less ▲]

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See detailThe California Verbal Learning Test and other standard clinical neuropsychological tests to predict conversion from mild memory impairment to dementia.
Lekeu, Françoise ULg; Magis, Delphine ULg; Marique, Patricia et al

in Journal of Clinical and Experimental Neuropsychology (2010), 20

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See detailIntroduction
Drouguet, Noémie ULg

in CeROArt : Conservation, Exposition, Restauration d'Objets d'Art (2010), 5

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See detailUveal inflammation in septic newborn foals.
Leiva, M.; Pena, T.; Armengou, L. et al

in Journal of veterinary internal medicine / American College of Veterinary Internal Medicine (2010), 24(2), 391-7

BACKGROUND: Septicemia in humans is described as a leading cause of uveitis, which eventually can induce blindness. HYPOTHESIS/OBJECTIVES: Uveal inflammatory findings could be related to sepsis severity ... [more ▼]

BACKGROUND: Septicemia in humans is described as a leading cause of uveitis, which eventually can induce blindness. HYPOTHESIS/OBJECTIVES: Uveal inflammatory findings could be related to sepsis severity in newborn foals and might be used as an indirect indicator for survival. ANIMALS: Seventy-four septic foals, 54 nonseptic foals, and 42 healthy foals. METHODS: Prospective observational clinical study. A detailed blinded, ophthalmic examination was performed by boarded ophthalmologists on all admitted newborn foals. Foals were grouped as septic (when blood culture resulted positive or the sepsis score was > or =14), nonseptic, and controls. Based on blood culture results, the septic group was subdivided into bacteremic and nonbacteremic foals. RESULTS: Blood culture was performed in 62/74 septic foals, from which 35 (56%) were bacteremic and 27 (44%) were non-bacteremic. Anterior uveitis was diagnosed in a significantly (P < .005) higher number of septic/bacteremic foals (14/35, 40%) than in septic/nonbacteremic foals (5/27, 19%), nonseptic foals (4/54, 7%), and control foals (0%). Anterior chamber fibrin was only observed in 4/14 (29%) septic/bacteremic foals with anterior uveitis. Anterior uveitis was also associated with posterior uveitis in 6/35 (19%) septic/bacteremic foals. The diagnosis of uveitis was related to nonsurvival (P = .001, odds ratio = 6.2, 95% confidence interval = 2.1-18.2). CONCLUSIONS AND CLINICAL IMPORTANCE: Anterior uveitis is highly prevalent in septic newborn foals, especially in those with a positive blood culture, and it should be considered as a survival prognostic factor. [less ▲]

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See detailFunctional interplay between macroH2A and Polycomb Repressive Complexes
Creppe, Catherine ULg; Valero, Vanesa; Di Croce, Luciano et al

Poster (2010)

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See detail2-Point correlation function of nanostructured materials via the grey-tone correlation function of electron tomograms: A three-dimensional structural analysis of ordered mesoporous silica
Gommes, Cédric ULg; Friedrich, Heiner; De Jongh, Petra E et al

in Acta Materialia (2010), 58

Electron tomography is a unique technique for imaging the microstructure of materials with a nanometer resolution. The signal to noise ratio of electron tomograms is, however, often too low for a reliable ... [more ▼]

Electron tomography is a unique technique for imaging the microstructure of materials with a nanometer resolution. The signal to noise ratio of electron tomograms is, however, often too low for a reliable segmentation-based image analysis. We derive a general relation between the grey-tone correlation function of the tomograms and the 2-point correlation function of the morphology, which enables to analyze quantitatively the grey-tone correlation function with a morphological model of the material. The methodology is applied to SBA-15 ordered mesoporous silica. The three-dimensional grey-tone correlation function obtained from electron tomography is analyzed in terms of a hexagonal array of Gaussian independent pores. The model enables to relate the morphology obtained from the 2-point correlation function to macroscopic characterization data of the material, notably small-angle X-ray scattering and nitrogen adsorption. [less ▲]

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See detailIMA Commission on New Minerals, Nomenclature and Classification (CNMNC), Newsletter 5
Williams, Pete; Hatert, Frédéric ULg; Pasero, Marco et al

in Mineralogical Magazine (2010), 74(5), 899-902

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See detailEye gaze and conscious processing in severely brain-injured patients
Chatelle, Camille ULg; Laureys, Steven ULg; Majerus, Steve ULg et al

in Behavioral and Brain Sciences (2010), 33(6), 442-443

Niedenthal et al. discuss the importance of eye gaze in embodied simulation and, more globally, in the processing of emotional visual stimulation (such as facial expression). In this commentary, we ... [more ▼]

Niedenthal et al. discuss the importance of eye gaze in embodied simulation and, more globally, in the processing of emotional visual stimulation (such as facial expression). In this commentary, we illustrate the relationship between oriented eye movements, consciousness, and emotion by using the case of severely brain-injured patients recovering from coma (i.e., vegetative and minimally conscious patients). [less ▲]

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See detailDetection and identification of hydrophilic selenium compounds in selenium-rich yeast by size exclusion-microbore normal-phase HPLC with the on-line ICP-MS and electrospray Q-TOF-MS detection
Far, Johann ULg; Preud'homme, Hugues; Lobinski, Ryszard

in Analytica Chimica Acta (2010), 657(2),

Normal-phase HPLC and hydrophilic interaction HPLC (HILIC) were investigated for the separation of selenometabolites in a water extract of Se-rich yeast prior to their detection by ICP-MS and ... [more ▼]

Normal-phase HPLC and hydrophilic interaction HPLC (HILIC) were investigated for the separation of selenometabolites in a water extract of Se-rich yeast prior to their detection by ICP-MS and identification by electrospray MS/MS. The targeted fraction was a low-abundant fraction co-eluting with salt and sulfur analogues in size-exclusion chromatography which has so far been inaccessible to Se speciation studies. The optimization of the separation conditions resulted in the highest separation efficiency when HILIC was used and elution was carried out isocratically with a low concentration ammonium acetate buffer (1 mM ammonium acetate/10mM acetic acid) in 80% acetonitrile. Out of 15 peaks observed with the Se-specific ICP-MS detection 12 was identified by electrospray Q-TOF MS/MS (2,3-dihydroxypropionyl (DHP)-Se-methylselenocysteine [M+H](+): 272, Se-methyl-gamma-glutamyl-selenocysteinylglycine dioxide [M+H](+): 402, gamma-glutanlyl-Se-methylselenocysteine[M+H](+): 313; isomers of gamma-glutamylselenocystathionine [M+H](+): 400; Se-methyl-selenoglutathione [M+H](+): 370, isomers of N-acetylselenocystathionine [M+H](+): 313, 2,3-DHP-selenohomolanthionine [M+H](+): 373, isomers of 2,3-DHP-seienocystathionine[M+H](+): 359,2,3-DHP-selenolanthionine [M+H](+): 345 and selenohomolanthionine [M+H](+): 285). (C) 2009 Elsevier B.V. All rights reserved. [less ▲]

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See detailLes deux laïcités
Jacquemain, Marc ULg

Learning material (2010)

Le document synthétise ce qui semble la ligne de fracture majeure au sein de la laïcité franco-belge : opposition entre une conception "républicaine" et une conception "libérale". Les deux peuvent se ... [more ▼]

Le document synthétise ce qui semble la ligne de fracture majeure au sein de la laïcité franco-belge : opposition entre une conception "républicaine" et une conception "libérale". Les deux peuvent se réclamer de la tradition laïque mais la première inclut une forme d'hostilité de principe à la religion qui est étrangère à la seconde. Le document tente de synthétiser les principales conséquences politiques de ces deux conceptions en passant en revue la neutralité des agents de l'Etat, la neutralité des citoyens et des élèves, ainsi que les discriminations indirectes et les accommodements raisonnables. Sur ces quatre points, les deux conceptions de la laïcité conduisent à des positions politiques différentes. Normativement, le document défend la primauté réelle, mais pas inconditionnelle, de la liberté d'expression. [less ▲]

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See detailThe Nociception Coma Scale to assess nociception in disorders of consciousness
Chatelle, Camille ULg; Schnakers, Caroline; VANHAUDENHUYSE, Audrey ULg et al

Poster (2010)

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See detailEEG-based Brain Computer Interface for Locked-In Patients
Chatelle, Camille ULg; Combaz, Adrien

Scientific conference (2010)

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See detailConsciousness in coma and related states
Chatelle, Camille ULg

Conference (2010)

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See detailLa perception de la douleur chez les patients en éveil de coma
Chatelle, Camille ULg

Conference (2010)

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See detailIdentification of a novel snake peptide displaying high affinity and antagonist behaviour for the alpha2-adrenoreceptors
Rouget, Céline; Quinton, Loïc ULg; Maïga, Arhamatoulaye et al

in British Journal of Pharmacology (2010), 161

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