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See detailDeletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis.
Docampo Martinez, Elisa ULg; Rabionet, Raquel; Riveira-Munoz, Eva et al

in Arthritis and rheumatism (2010), 62(5), 1246-51

OBJECTIVE: The risk of rheumatoid arthritis (RA) is increased in the offspring of individuals affected with various autoimmune disorders, including psoriasis. Recently, the deletion of 2 genes from the ... [more ▼]

OBJECTIVE: The risk of rheumatoid arthritis (RA) is increased in the offspring of individuals affected with various autoimmune disorders, including psoriasis. Recently, the deletion of 2 genes from the late cornified envelope (LCE) gene cluster, LCE3C and LCE3B, has been associated with psoriasis in several populations. The purpose of this study was to assess whether this polymorphic gene deletion could also be involved in susceptibility to RA. METHODS: We tested for association between the LCE3C_LCE3B copy number variant and a single-nucleotide polymorphism in strong linkage disequilibrium with this variant (rs4112788) and RA in 2 independent case-control data sets (197 and 400 samples from patients with RA, respectively, and 411 and 567 samples from control subjects, respectively), collected at 4 Spanish hospitals. All samples were directly typed for presence of the LCE3C_LCE3B deletion (LCE3C_LCE3B-del) by polymerase chain reaction, and association analysis was performed using the SNPassoc R package. RESULTS: An association of homozygosity for the LCE3C_LCE3B-del and rs4112788 C allele with the risk of RA was observed in the first data set and was replicated in an independent case-control set. A combined analysis showed an overall P value of 0.0012 (odds ratio [OR] 1.45, 95% confidence interval [95% CI] 1.16-1.81) for association of the LCE3C_LCE3B-del. When the analysis was stratified for serologic data, we observed association in anti-cyclic citrullinated peptide (anti-CCP)-positive patients (P = 0.012, OR 1.51 [95% CI 1.09-2.13]) but not in anti-CCP-negative patients. CONCLUSION: We have identified an association between the LCE3C_LCE3B-del and RA, and we have verified a pleiotropic effect of a common genetic risk factor (LCE3C_LCE3B-del) for autoimmune diseases that is involved in both psoriasis and RA. [less ▲]

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See detailMicroRNAs in the tumor endothelium: novel controls on the angioregulatory switchboard
Heusschen, Roy ULg; van Gink, Matthijs; Griffioen, Arjan et al

in Biochimica et Biophysica Acta - Reviews on Cancer (2010), 1805

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See detailCombined PIXE/PIGE and IBIL with external beam applied to the analysis of Merovingian glass beads
Mathis, François ULg; Othmane, G.; Vrielynck, Olivier et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (2010), 268(11-12), 2078-2082

New improvements on our archaeometry line at the cyclotron of the Institute of Nuclear and Atomic Physics and of Spectrometry of the University of Liege have allowed the use of PIXE/PIGE and IBIL in-air ... [more ▼]

New improvements on our archaeometry line at the cyclotron of the Institute of Nuclear and Atomic Physics and of Spectrometry of the University of Liege have allowed the use of PIXE/PIGE and IBIL in-air for the analysis of cultural heritage objects. The extraction is performed through a 100 nm thick Si3N4 window. The detection set-up consists now of two X-ray and one gamma-ray detectors, together with a fiber optic UV-visible spectrometer. This set-up has already been tested for the analysis of modern corundum [1] and is now adapted to the analysis of archaeological artefacts. In this work, we have used it to analyse 216 out of the 5000 Merovingian glass beads that come from the necropolis of Bossut-Gottechain (Belgium), one of the most important ever found in Belgium. The IBA analyses confirmed the typological division of different beads groups through chemical composition that gives us new insights on fabrication techniques of glass matrices and colorants. (C) 2010 Elsevier B.V. All rights reserved. [less ▲]

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See detailWhich rules shape EU's external governance? The patterns of rule selection in foreign and security policies
Barbé, Esther; Costa, Oriol; Herranz-Surrallés, Anna et al

in Lavenex, Sandra; Schimmelfennig, Frank (Eds.) EU External Governance: Projecting EU Rules beyond Membership (2010)

This article addresses a particular aspect of EU external governance: rule selection. Drawing on institutionalist and power-based explanations we put forward an account for the choice of the specific ... [more ▼]

This article addresses a particular aspect of EU external governance: rule selection. Drawing on institutionalist and power-based explanations we put forward an account for the choice of the specific rules that guide policy convergence between the EU and third countries. The proposed analytical framework broadens the scope of the studies examining the externalization of EU rules beyond its borders, in that we claim that the EU can promote policy convergence using rules other than the EU's. More specifically, the EU also promotes policy convergence on the basis of international and bilaterally developed rules. These analytical claims for explaining rule selection are checked against empirical data. We compare policy convergence between the EU and four neighbouring countries (Morocco, Ukraine, Georgia, and Russia) in three subfields within foreign and security policy: foreign policy dialogue, control of export of dual-use goods in the context of non-proliferation of weapons of mass destruction, and crisis management. [less ▲]

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See detailResidence time and exposure time of sinking phytoplankton in the euphotic layer
Delhez, Eric ULg; Deleersnijder, Eric

in Journal of Theoretical Biology (2010), 262

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See detailTreatment and assessment of the CO2-exchange at a complex forest site in Thuringia, Germany
Rebmann, Corinna; Zeri, Marcelo; Lasslop, Gitta et al

in Agricultural and Forest Meteorology (2010), 150(5), 684-691

Eddy covariance measurements were carried out at the Wetzstein site in Thuringia, Germany since December 2001. Soon after the start of the measurements night-time fluxes well above average CO2-fluxes ... [more ▼]

Eddy covariance measurements were carried out at the Wetzstein site in Thuringia, Germany since December 2001. Soon after the start of the measurements night-time fluxes well above average CO2-fluxes measured in temperate forest ecosystems were detected which could not be explained by biological processes but were valid with respect to standard quality criteria. The Wetzstein site is part of the CarboEurope-IP flux-network and the CO2-exchange of this spruce forest is of general ecological interest as the site is typical for central European spruce forest ecosystems at mountainous elevation. Additional investigations were made in order to identify the causes for the large difference between the flux balance and the inventory based NEP. Specific weather patterns and micrometeorological situations were identified during which a decoupling of the flows above and below the canopy leads to additional CO2-effluxes at the tower site which are not part of the net ecosystem exchange (NEE) at night. Rejecting data from these periods and gap-filling thereafter results in yearly sums of NEE, GPP and TER which are in better agreement with the biometric measurements at the tower site and comparable to other spruce forest sites. In this process ecosystem respiration was determined not only from extrapolation of nighttime data but also from flux partitioning based on day-time data using the hyperbolic light response function. It can be shown that flux measurements at this complex site need to be treated in a modified procedure compared to what is generally performed, namely extrapolating ecosystem respiration from night-time data. Using multiple data sources and applying a careful filtering of the data, confidence in the estimates of the carbon balance components increased. [less ▲]

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See detailLes défis du droit romain et du droit privé comparé
Gerkens, Jean-François ULg

in Gosselin, Antoinette; Langevin, Caroline; Wautelet, Patrick (Eds.) L'avenir de la recherche: Réflexions à l'occasion des leçons inaugurales 2010 (2010)

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See detailEnteropathogenic (EPEC), enterohaemorragic (EHEC) and verotoxigenic (VTEC) Escherichia coli in wild cervids
Bardiau, Marjorie ULg; Grégoire, Fabien ULg; Muylaert, Adeline ULg et al

in Journal of Applied Microbiology (2010), 109(6), 2214-2222

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See detailSignspeak--understanding, recognition, and translation of sign languages
Dreuw, Philippe; Forster, Jens; Gweth, Yannick et al

in 4th Workshop on the Representation and Processing of Sign Languages: Corpora and Sign Language Technologies (2010)

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See detailFaire un faux pas face a des syphilides "de deuxieme floraison".
El Hayderi, L.; Pierard, Gérald ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2010), 65(5-6), 420-2

In a recent past, the incidence of syphilis has increased in various geographical regions, particularly in urban areas. In addition, the disease is particularly associated with HIV infection. In secondary ... [more ▼]

In a recent past, the incidence of syphilis has increased in various geographical regions, particularly in urban areas. In addition, the disease is particularly associated with HIV infection. In secondary syphilis, the diagnosis may prove to be particularly difficult to reach because the clinico-pathological resemblance with other skin disorders is commonly high. The risk of diagnostic roaming is associated with therapeutic inertia which is highly prejudiciable to the patient. [less ▲]

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See detailLes nouveaux défis de l'enseignement du français langue étrangère en Europe
Defays, Jean-Marc ULg

in Dialogues et Cultures (2010), 56

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See detailThe umbilical cord matrix is a better source of mesenchymal stem cells (MSC) than the umbilical cord blood.
Zeddou, Mustapha ULg; Briquet, Alexandra ULg; Relic, Biserka ULg et al

in Cell Biology International (2010), 34(7), 693-701

Many studies have drawn attention to the emerging role of MSC (mesenchymal stem cells) as a promising population supporting new clinical concepts in cellular therapy. However, the sources from which these ... [more ▼]

Many studies have drawn attention to the emerging role of MSC (mesenchymal stem cells) as a promising population supporting new clinical concepts in cellular therapy. However, the sources from which these cells can be isolated are still under discussion. Whereas BM (bone marrow) is presented as the main source of MSC, despite the invasive procedure related to this source, the possibility of isolating sufficient numbers of these cells from UCB (umbilical cord blood) remains controversial. Here, we present the results of experiments aimed at isolating MSC from UCB, BM and UCM (umbilical cord matrix) using different methods of isolation and various culture media that summarize the main procedures and criteria reported in the literature. Whereas isolation of MSC were successful from BM (10:10) and (UCM) (8:8), only one cord blood sample (1:15) gave rise to MSC using various culture media [DMEM (Dulbecco's modified Eagle's medium) +5% platelet lysate, DMEM+10% FBS (fetal bovine serum), DMEM+10% human UCB serum, MSCGM] and different isolation methods [plastic adherence of total MNC (mononuclear cells), CD3+/CD19+/CD14+/CD38+-depleted MNC and CD133+- or LNGFR+-enriched MNC]. MSC from UCM and BM were able to differentiate into adipocytes, osteocytes and hepatocytes. The expansion potential was highest for MSC from UCM. The two cell populations had CD90+/CD73+/CD105+ phenotype with the additional expression of SSEA4 and LNGFR for BM MSC. These results clearly exclude UCB from the list of MSC sources for clinical use and propose instead UCM as a rich, non-invasive and abundant source of MSC. [less ▲]

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See detailOperational multipartite entanglement classes for symmetric photonic qubit states
Kiesel, N.; Wieczorek, W.; Krins, Stéphanie ULg et al

Poster (2010)

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See detailOn a class of micromechanical damage models with initial stresses for geomaterials
Levasseur, Séverine ULg; Collin, Frédéric ULg; Charlier, Robert ULg et al

in Mechanics Research Communications (2010), 37

In this paper, we extend a class of micromechanical damage models by including initial stresses. The proposed approach is based on the solution of the Eshelby inhomogeneous inclusion problem in the ... [more ▼]

In this paper, we extend a class of micromechanical damage models by including initial stresses. The proposed approach is based on the solution of the Eshelby inhomogeneous inclusion problem in the presence of a prestress (in the matrix), adapted for elastic voided media. The closed form expression of the corresponding energy potential is used as the basis of various isotropic damage models corresponding to three standard homogenization schemes. These models are illustrated by considering isotropic tensile loadings with different initial stresses. Finally, still in the isotropic context, we provide an interpretation of the macroscopic damage model formulated by Halm-Dragon (1996) by briefly connecting it to the present study. [less ▲]

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See detailHydro-mechanical modelling of the Excavation Damaged Zone around an underground excavation at Mont Terri Rock Laboratory
Levasseur, Séverine ULg; Charlier, Robert ULg; Frieg, Bernd et al

in International Journal of Rock Mechanics & Mining Sciences (2010), 47(3), 414-425

A zone with significant irreversible deformations and significant changes in flow and transport properties is expected to be formed in indurated clay around underground excavations. The stress ... [more ▼]

A zone with significant irreversible deformations and significant changes in flow and transport properties is expected to be formed in indurated clay around underground excavations. The stress perturbation around the excavation could lead to a significant increase of the permeability, related to diffuse and/or localized crack propagation in the material. The main objective of the study is to model these processes at large scale in order to assess their impacts on the performance of radioactive waste geological repositories. This paper concerns more particularly the hydro-mechanical modelling of a long term dilatometer experiment performed in Mont Terri Rock Laboratory in Switzerland within the Selfrac Project. The proposed model defines the permeability as a function of the aperture of the cracks that are generated during the excavation. With this model, the permeability tensor becomes anisotropic. Advantages and drawbacks of this approach are described thanks to the results of the Selfrac long term dilatometer experiment. [less ▲]

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See detailBrainstem specific warping improves locus coeruleus functional imaging in humans
Balteau, Evelyne ULg; Schmidt, Christina ULg; Maquet, Pierre ULg et al

in Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society For Magnetic Resonance in Medicine. Scientific Meeting and Exhibition (2010)

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