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See detailPyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-kappaB activation.
Mortier, Jeremie; Frederick, Raphael; Ganeff, Corinne et al

in Biochemical Pharmacology (2010), 79(10), 1462-72

In this work, we aimed to build a 3D-model of NIK and to study the binding of pyrazolo[4,3-c]isoquinolines with a view to highlight the structural elements responsible for their inhibitory potency ... [more ▼]

In this work, we aimed to build a 3D-model of NIK and to study the binding of pyrazolo[4,3-c]isoquinolines with a view to highlight the structural elements responsible for their inhibitory potency. However, in the course of this work, we unexpectedly found that the pyrazolo[4,3-c]isoquinolines initially reported as NIK inhibitors were neither inhibitors of this enzyme nor of the alternative NF-kappaB pathway, but were in fact inhibitors of another kinase, the TGF-beta activated kinase 1 (TAK1) which is involved in the classical NF-kappaB pathway. [less ▲]

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See detailPlant-RNA viroid relationship: a complex host pathogen interaction
Parisi, Olivier ULg; Lepoivre, Philippe ULg; Jijakli, Haissam ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2010), 14(3),

Viroids are non encapsidated small RNA plant pathogens unable to produce any protein. They are able to infect dramatically a broad range of plants including herbaceous and tree crops. The ways by which ... [more ▼]

Viroids are non encapsidated small RNA plant pathogens unable to produce any protein. They are able to infect dramatically a broad range of plants including herbaceous and tree crops. The ways by which viroids are able to induce diseases are actually unknown. However, recent studies have shown that viroids are able to regulate the gene expression of their hosts, they can modify the host-protein phosphorylation sensibility and they interact with host-protein implicated RNA trafficking and protein phosphorylation. Moreover during their evolution plants have developed a mechanism able to regulate their gene expression and to degrade exogenous RNAs like viroids: the gene silencing. Unfortunately, this pathway seems, now, also highly implicated in the symptoms development. This review describes studies that are realized since a few years to increase the knowledge about the plant-viroid relationship. [less ▲]

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See detailLes nouveaux défis de l'enseignement du français langue étrangère en Europe
Defays, Jean-Marc ULg

in Dialogues et Cultures (2010), 56

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See detailIdentification of a novel snake peptide displaying high affinity and antagonist behaviour for the alpha2-adrenoreceptors
Rouget, Céline; Quinton, Loïc ULg; Maïga, Arhamatoulaye et al

in British Journal of Pharmacology (2010), 161

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See detailFollicular fluids, immunological fingerprint and infertility
Lédée, N; Munaut, Carine ULg; PERRIER d'HAUTERIVE, Sophie ULg et al

Conference (2010)

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See detailMaternal plasma soluble endoglin at 11-13 weeks's gestation in pre-eclampsia
Foidart, Jean-Michel ULg; Munaut, Carine ULg; Chantraine, Frédéric ULg et al

in Ultrasound in Obstetrics & Gynecology (2010), 35(6), 680-7

Objectives: To examine the performance of screening for preeclampsia (PE) by a combination of maternal factors, soluble endoglin (sEng), pregnancy associated plasma protein A (PAPP-A), placental growth ... [more ▼]

Objectives: To examine the performance of screening for preeclampsia (PE) by a combination of maternal factors, soluble endoglin (sEng), pregnancy associated plasma protein A (PAPP-A), placental growth factor (PlGF) and uterine artery lowest pulsatibility index (L-PI) at 11-13 weeks of gestation. Methods: Uterine artery L-PI, sEng, PAPP-A and PlGF were measured at 11-13 weeks in 90 singleton pregnancies that subsequently developed PE, including 30 that required delivery before 34 weeks (early-PE) and 60 with late-PE, and 180 unaffected controls. Screening performance for PE by maternal factors, sEng, PAPP-A, PlGF and uterine artery L-PI and their combinations was determined. Results: In early-PE, compared to controls, plasma sEng and uterine L-PI were significantly increased and serum PAPP-A and PlGF were decreased. In late-PE, compared to controls, serum PlGF was decreased and uterine L-PI was increased but plasma sEng and serum PAPP-A were not significantly different. In screening for early-PE, the detection rate at a 10% false positive rate was 46.7% for sEng alone and 96.3% for a combination of maternal factors, sEng, PlGF and uterine artery L-PI. Conclusions: Effective screening for early-PE can be provided by a combination of maternal factors, sEng, PlGF and uterine artery L-PI at 11-13 weeks. [less ▲]

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See detailDeletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis.
Docampo Martinez, Elisa ULg; Rabionet, Raquel; Riveira-Munoz, Eva et al

in Arthritis and rheumatism (2010), 62(5), 1246-51

OBJECTIVE: The risk of rheumatoid arthritis (RA) is increased in the offspring of individuals affected with various autoimmune disorders, including psoriasis. Recently, the deletion of 2 genes from the ... [more ▼]

OBJECTIVE: The risk of rheumatoid arthritis (RA) is increased in the offspring of individuals affected with various autoimmune disorders, including psoriasis. Recently, the deletion of 2 genes from the late cornified envelope (LCE) gene cluster, LCE3C and LCE3B, has been associated with psoriasis in several populations. The purpose of this study was to assess whether this polymorphic gene deletion could also be involved in susceptibility to RA. METHODS: We tested for association between the LCE3C_LCE3B copy number variant and a single-nucleotide polymorphism in strong linkage disequilibrium with this variant (rs4112788) and RA in 2 independent case-control data sets (197 and 400 samples from patients with RA, respectively, and 411 and 567 samples from control subjects, respectively), collected at 4 Spanish hospitals. All samples were directly typed for presence of the LCE3C_LCE3B deletion (LCE3C_LCE3B-del) by polymerase chain reaction, and association analysis was performed using the SNPassoc R package. RESULTS: An association of homozygosity for the LCE3C_LCE3B-del and rs4112788 C allele with the risk of RA was observed in the first data set and was replicated in an independent case-control set. A combined analysis showed an overall P value of 0.0012 (odds ratio [OR] 1.45, 95% confidence interval [95% CI] 1.16-1.81) for association of the LCE3C_LCE3B-del. When the analysis was stratified for serologic data, we observed association in anti-cyclic citrullinated peptide (anti-CCP)-positive patients (P = 0.012, OR 1.51 [95% CI 1.09-2.13]) but not in anti-CCP-negative patients. CONCLUSION: We have identified an association between the LCE3C_LCE3B-del and RA, and we have verified a pleiotropic effect of a common genetic risk factor (LCE3C_LCE3B-del) for autoimmune diseases that is involved in both psoriasis and RA. [less ▲]

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See detailThe effect of tumor-associated protein RCAS1 gene silencing on blood pressure and urinary protein excretion in pregnant mouse: a pilot study.
Tskitishvili, Ekaterine ULg; Nakamura, Hitomi; Kinugasa-Taniguchi, Yukiko et al

in American Journal of Obstetrics and Gynecology (2010), 203(4), 3646-36412

OBJECTIVE: The level of tumor-associated receptor-binding cancer antigen that is expressed on SiSo cells (RCAS1) is decreased significantly in preeclamptic pregnancies. We hypothesized that RCAS1 protein ... [more ▼]

OBJECTIVE: The level of tumor-associated receptor-binding cancer antigen that is expressed on SiSo cells (RCAS1) is decreased significantly in preeclamptic pregnancies. We hypothesized that RCAS1 protein gene silencing might affect blood pressure and proteinuria in pregnant mice. STUDY DESIGN: On postcoital day 7.5, pregnant imprinting control region mice were subjected to the transfer of small interfering RNA (siRNA) against RCAS1 protein into the uterine cavity with the use of a hemagglutinating virus Japan envelope. Scramble siRNA was used as a negative control. Blood pressure and urine albumin/creatinine measurements were performed. The effect of the transferred siRNA was examined in uterine samples on postcoital day 8.5 with the use of Western blotting and immunohistochemistry analyses. RESULTS: In the RCAS1 siRNA group, blood pressure significantly raised on postcoital days 9.5, 10.5, 11.5, and 15.5, whereas urine albumin/creatinine ratio was significantly increased on postcoital day 9.5 CONCLUSION: Our results suggest the importance of RCAS1 protein in the pathophysiologic condition of preeclampsia. [less ▲]

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See detailWhich rules shape EU's external governance? The patterns of rule selection in foreign and security policies
Barbé, Esther; Costa, Oriol; Herranz-Surrallés, Anna et al

in Lavenex, Sandra; Schimmelfennig, Frank (Eds.) EU External Governance: Projecting EU Rules beyond Membership (2010)

This article addresses a particular aspect of EU external governance: rule selection. Drawing on institutionalist and power-based explanations we put forward an account for the choice of the specific ... [more ▼]

This article addresses a particular aspect of EU external governance: rule selection. Drawing on institutionalist and power-based explanations we put forward an account for the choice of the specific rules that guide policy convergence between the EU and third countries. The proposed analytical framework broadens the scope of the studies examining the externalization of EU rules beyond its borders, in that we claim that the EU can promote policy convergence using rules other than the EU's. More specifically, the EU also promotes policy convergence on the basis of international and bilaterally developed rules. These analytical claims for explaining rule selection are checked against empirical data. We compare policy convergence between the EU and four neighbouring countries (Morocco, Ukraine, Georgia, and Russia) in three subfields within foreign and security policy: foreign policy dialogue, control of export of dual-use goods in the context of non-proliferation of weapons of mass destruction, and crisis management. [less ▲]

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See detailIMA Commission on New Minerals, Nomenclature and Classification (CNMNC), Newsletter 5
Williams, Pete; Hatert, Frédéric ULg; Pasero, Marco et al

in Mineralogical Magazine (2010), 74(5), 899-902

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See detailOperational multipartite entanglement classes for symmetric photonic qubit states
Kiesel, N.; Wieczorek, W.; Krins, Stéphanie ULg et al

Poster (2010)

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See detailEffect of an electric field on an intermittent granular flow
Mersch, Eric ULg; Lumay, Geoffroy ULg; Boschini, Frédéric ULg et al

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2010), 81

Granular gravity driven flows of glass beads have been observed in a silo with a flat bottom. A dc high electric field has been applied perpendicularly to the silo to tune the cohesion. The outlet mass flow ... [more ▼]

Granular gravity driven flows of glass beads have been observed in a silo with a flat bottom. A dc high electric field has been applied perpendicularly to the silo to tune the cohesion. The outlet mass flow has been measured. An image subtraction technique has been applied to visualize the flow geometry and a spatiotemporal analysis of the flow dynamics has been performed. The outlet mass flow is independent of voltage, but a transition from funnel flow to rathole flow is observed. This transition is of probabilistic nature and an intermediate situation exists between the funnel and the rathole situations. At a given voltage, two kinds of flow dynamics can occur: a continuous flow or an intermittent flow. The electric field increases the probability to observe an intermittent flow. [less ▲]

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See detailSignspeak--understanding, recognition, and translation of sign languages
Dreuw, Philippe; Forster, Jens; Gweth, Yannick et al

in 4th Workshop on the Representation and Processing of Sign Languages: Corpora and Sign Language Technologies (2010)

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See detailThe net biome production of full crop rotations in Europe
Kutsch, W. L.; Aubinet, Marc ULg; Buchmann, N. et al

in Agriculture, Ecosystems & Environment (2010), 139

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See detailIntroduction to Electromechanical Coupling
Rochus, Véronique ULg

in Computer and Experimental Simulations in Engineering and Science [=CESES] (2010), (7),

This paper is dedicated to the physical understanding of electrostatic forces with a one-dimensional reference problem. First a non-dimensional analysis prescribes the kind of assumptions to consider for ... [more ▼]

This paper is dedicated to the physical understanding of electrostatic forces with a one-dimensional reference problem. First a non-dimensional analysis prescribes the kind of assumptions to consider for the electric field model. An analytical study of electro-mechanical coupling is then performed to understand the type of non-linearity added by electrostatic forces, and static and dynamic analysis are used to define new characteristic parameters. To come closer to more realistic problems, cubic mechanical stiffness is added to account for the large displacement hypothesis prescribed for certain types of MEMS and damping effects are studied. [less ▲]

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