References of "2010"
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See detailL'étalement urbain coûte cher. Où en est le débat ?
Halleux, Jean-Marie ULiege

in ADEF (Ed.) Repenser le foncier - La ressource foncière au coeur du changement (2010)

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See detailMagma flow and feeder chamber location inferred from magnetic fabrics in jotunitic dykes (Rogaland anorthosite province, SW Norway)
Bolle, Olivier ULiege; Besse, Michal; Diot, Hervé

in Tectonophysics (2010), 493(1-2), 42-57

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See detailChapitre 12. Littérature : entre insularité et activisme
Denis, Benoît ULiege; Klinkenberg, Jean-Marie ULiege

in Delhalle, Nancy; Dubois, Jacques (Eds.) Le tournant des années 1970. Liège en effervescence (2010)

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See detailIMA Commission on New Minerals, Nomenclature and Classification (CNMNC), Newsletter 6
Williams, Pete; Hatert, Frédéric ULiege; Pasero, Marco et al

in Mineralogical Magazine (2010), 74(6), 941-942

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See detailFiche descriptive - Les spirées nord-américaines (Spiraea spp.)
Halford, Mathieu ULiege; Frisson, Gwenn ULiege; Delbart, Emmanuel ULiege et al

Learning material (2010)

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See detailEnsemble smoother for optimizing tidal boundary conditions and wind forcing by assimilation of High-Frequency Radar surface currents measurements of the German Bight
Barth, Alexander ULiege; Alvera Azcarate, Aïda ULiege; Staneva, Joanna et al

Conference (2010)

An ensemble smoother scheme is presented to assimilate HF radar surface currents to improve tidal boundary conditions and wind forcings of a circulation model of the German Bight. To create an ensemble of ... [more ▼]

An ensemble smoother scheme is presented to assimilate HF radar surface currents to improve tidal boundary conditions and wind forcings of a circulation model of the German Bight. To create an ensemble of dynamically realistic tidal boundary conditions, a cost function is formulated which is directly related to the probability of each perturbation. This cost function ensures that the perturbations are spatially smooth and that the structure of the perturbations satisfies approximately the harmonic linearized shallow water equations. Based on those perturbations an ensemble simulation is carried out using the full three-dimensional General Estuarine Ocean Model (GETM). Optimized boundary values are obtained using all observations within the assimilation period using the covariances of the ensemble simulation. The approach acts like a smoother scheme since all observations are taken into account. Since the scheme aims to derive the optimal perturbation, it might be called Ensemble Perturbation Smoother. The final analysis is obtained by rerunning the model using the optimal perturbation to the boundary conditions. The analyzed model solution satisfies thus the model equations exactly and does not suffer from spurious adjustments often observed with sequential assimilation schemes. Model results are also compared to independent tide gage data. The assimilation did also reduce the model error compared to those sea level observations. The same scheme has also been used to correct surface winds. Surface winds are crucial for accurately modeling the marine circulation in coastal waters. The method is validated directly by comparing the analyzed wind speed to in situ measurements and indirectly by assessing the impact of the corrected winds on sea surface temperature (SST) relative to satellite SST. [less ▲]

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See detailMusica, musicos e o voto latino na eleiçao presidencial americana del 2008
Lafleur, Jean-Michel ULiege; Martiniello, Marco ULiege

in Migrações (2010), (7), 229-247

This article seeks to examine the relevance of popular culture and music in particular in the context of post-migratory multicultural societies. More precisely, we aim to demonstrate how music and ... [more ▼]

This article seeks to examine the relevance of popular culture and music in particular in the context of post-migratory multicultural societies. More precisely, we aim to demonstrate how music and musicians contribute – in specific spatial and temporal settings – to the mobilization of some migrant origin populations. The article starts with a conceptual discussion on the role of music for ethnic and migrant groups and on the role of music and musicians in electoral campaigns. Subsequently, we review the case of the 2008 US presidential campaign to show the relevance of minority artists’ productions and the political use that can be made out of it in competitive electoral contexts such as that of the United States. [less ▲]

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See detailThixoextrusion of A357 aluminium alloy
Forn, Antonio; Rassili, Ahmed ULiege; Vaneetveld, Grégory ULiege et al

in Transactions of Nonferrous Metals Society of China (2010)

The aim of this work is to attempt the application of A357 Al-Si-Mg cast alloy in the thixoextrusion process, evaluating the different parameters effect. Thixoextrusion offers several advantages compared ... [more ▼]

The aim of this work is to attempt the application of A357 Al-Si-Mg cast alloy in the thixoextrusion process, evaluating the different parameters effect. Thixoextrusion offers several advantages compared to traditional hot-extrusion such as lower pressure, minor friction forces, higher material fluidity, longer tool life, etc. This type of semi-solid process requires high solid fractions (0.5<fs<1). Aluminium alloy A357 is a commercial cast alloy characterized by high strength, ductility and corrosion resistance. It is commonly used for cast production of automotive components and it is also suitable for semi-solid process, due to its ample range of solidification. A357 aluminium alloy has been used as a feedstock for thixoextrusion in order to investigate thixoformability at high solid fraction. Alloys with high solid fraction are less sensitive to temperature drops and allow laminar flow at higher speeds. To know the parameters that improve the mechanical properties of thixoextruded parts, some extrusion tests at constant speeds have been carried out. The results were used as the main criteria for assessing the thixoforming viability of the A357 alloy. [less ▲]

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See detailRapport 3 (comité de thèse)
Zirbes, Lara ULiege

Report (2010)

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See detailEPOCA/EUR-OCEANS data compilation on the biological and biogeochemical responses to ocean acidification
Nisumaa, A.-M.; Pesant, S.; Bellerby, R.G.J. et al

in Earth System Science Data (2010), 2

The uptake of anthropogenic CO2 by the oceans has led to a rise in the oceanic partial pressure of CO2, and to a decrease in pH and carbonate ion concentration. This modification of the marine carbonate ... [more ▼]

The uptake of anthropogenic CO2 by the oceans has led to a rise in the oceanic partial pressure of CO2, and to a decrease in pH and carbonate ion concentration. This modification of the marine carbonate system is referred to as ocean acidification. Numerous papers report the effects of ocean acidification on marine organisms and communities but few have provided details concerning full carbonate chemistry and complementary observations. Additionally, carbonate system variables are often reported in different units, calculated using different sets of dissociation constants and on different pH scales. Hence the direct comparison of experimental results has been problematic and often misleading. The need was identified to (1) gather data on carbonate chemistry, biological and biogeochemical properties, and other ancillary data from published experimental data, (2) transform the information into common framework, and (3) make data freely available. The present paper is the outcome of an effort to integrate ocean carbonate chemistry data from the literature which has been supported by the European Network of Excellence for Ocean Ecosystems Analysis (EUR-OCEANS) and the European Project on Ocean Acidification (EPOCA). A total of 185 papers were identified, 100 contained enough information to readily compute carbonate chemistry variables, and 81 data sets were archived at PANGAEA – The Publishing Network for Geoscientific & Environmental Data. This data compilation is regularly updated as an ongoing mission of EPOCA. Data access: http://doi.pangaea.de/10.1594/PANGAEA.735138 [less ▲]

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See detailA two-scale model for subcritical damage propagation
Dascalu, Cristian; François, Bertrand ULiege; Keita, Oumar

in International Journal of Solids and Structures (2010), 47(3-4), 493-502

The failure behaviour of quasi-brittle materials is often time-dependent. This dependence is due to physical processes taking place at the level of the micro-structure. For a rigorous modeling of the time ... [more ▼]

The failure behaviour of quasi-brittle materials is often time-dependent. This dependence is due to physical processes taking place at the level of the micro-structure. For a rigorous modeling of the time-dependent behaviour of that kind of solids, a two-scale approach is well suited. This paper investigates time-dependent damage which microscopic origin is the subcritical micro-crack growth. We present a two-scale time-dependent damage model completely deduced from small-scale descriptions of subcritical micro-crack propagation, without any macroscopic assumptions. The passage from the micro-scale to the macro-scale is done through an asymptotic homogenization approach. At the micro-scale, the tensile failure due to the subcritical propagation of cracks is the dominant mechanism of creep observed at the macro-scale. We consider microstructures with cracks evolving in different subcritical regimes. We assume a complex propagation law that considers three characteristic regimes of subcritical crack growth, corresponding to different physical processes at the crack tip level. Numerical simulations of constant strain rate, relaxation and creep tests illustrate the ability of the developed model to reproduce different regimes of time-dependent damage response. [less ▲]

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See detailImmunosuppressant combined with infliximab in Crohn's Disease: For 6 months, for 2 years, or forever?
Louis, Edouard ULiege

in Inflammatory Bowel Diseases (2010)

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See detailDo clinical factors help to predict disease course in inflammatory bowel disease?
Louis, Edouard ULiege; Belaiche, Jacques ULiege; Reenaers, Catherine ULiege

in World Journal of Gastroenterology (2010), 16(21), 2600-3

While therapeutic strategies able to change the natural history of the disease are developing, it is of major importance to have available predictive factors for aggressive disease to try and target these ... [more ▼]

While therapeutic strategies able to change the natural history of the disease are developing, it is of major importance to have available predictive factors for aggressive disease to try and target these therapeutic strategies. Clinical predictors have probably been the most broadly studied. In both Crohn's disease (CD) and ulcerative colitis (UC), age at diagnosis, disease location and smoking habit are currently the strongest predictors of disease course. A younger age at onset is associated with more aggressive disease both in CD and UC. Disease location in CD is associated with different types of complications: surgery and recurrence in upper gastrointestinal and proximal small bowel disease; and surgery in distal small bowel disease and peri-anal lesions in rectal disease. In UC, extensive colitis is clearly been associated with more severe disease. Finally, active smoking globally increases disease severity in CD but decreases it in UC. Besides these important factors, others may predispose to some specific disease evolution and complications, and are also reviewed in the present paper. [less ▲]

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See detailSevere skin lesions cause patients with inflammatory bowel disease to discontinue anti-tumor necrosis factor therapy.
Rahier, Jean*-Francois; Buche, Sebastien; Peyrin-Biroulet, Laurent et al

in Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of The American Gastroenterological Association (2010), 8(12), 1048-55

BACKGROUND & AIMS: Psoriasiform and eczematiform lesions are associated with anti-tumor necrosis factor (TNF)-alpha therapies. We assessed clinical characteristics, risk factors, and outcomes of skin ... [more ▼]

BACKGROUND & AIMS: Psoriasiform and eczematiform lesions are associated with anti-tumor necrosis factor (TNF)-alpha therapies. We assessed clinical characteristics, risk factors, and outcomes of skin disease in patients with inflammatory bowel diseases that presented with psoriasiform and eczematiform lesions induced by anti-TNF-alpha agents. METHODS: We studied 85 patients (69 with Crohn's disease, 15 with ulcerative colitis, and 1 with indeterminate colitis; 62 women) with inflammatory skin lesions (62 psoriasiform and 23 eczematiform lesions). RESULTS: Twenty-four patients had a history of inflammatory skin lesions and 15 had a familial history of inflammatory skin disease. Locations of eczematiform lesions varied whereas scalp and flexural varieties were mostly psoriasiform. Skin lesions emerged but inflammatory bowel disease was quiescent in 69 patients following treatment with any type of anti-TNF-alpha agent (60 with infliximab, 20 with adalimumab, and 5 with certolizumab). Topical therapy resulted in partial or total remission in 41 patients. Patients with psoriasiform lesions that were resistant to topical therapy and that changed anti-TNF-alpha therapies once or twice developed recurring lesions. Overall, uncontrolled skin lesions caused 29 patients to stop taking TNF-alpha inhibitors. CONCLUSIONS: Inflammatory skin lesions following therapy with TNF-alpha inhibitors occurred most frequently among women and patients with a personal or familial history of inflammatory skin disease; lesions did not correlate with intestinal disease activity. Recurring and intense skin lesions caused 34% of patients in this study to discontinue use of anti-TNF-alpha agents. [less ▲]

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See detailPrescribed regimen is effective.
Reginster, Jean-Yves ULiege; Altman, Roy D; Hochberg, Marc C

in BMJ (Clinical Research ed.) (2010), 341

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See detailMorphemes in the mind: Are there graded effects of semantic similarity on morphological processing in children?
Deacon, Hélène; Downing, Jennifer; Gonnerman, Laura et al

Conference (2010)

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See detailPolymer maximum drag reduction: A unique transitional state
Dubief, Yves; White, Christopher M.; Shaqfeh, Eric S. G. et al

in Annual Research Briefs (2010)

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See detailCamelid single-domain antibody fragments as structural probes to study the mechanism of human lysozyme fibrils formation
Dumont, Janice ULiege; Pardon, Els; Menzer, Linda ULiege et al

Poster (2010)

Six variants of human lysozyme (single-point mutations I56T, F57I, W64R, D67H and double mutations F57I/T70N, W112R/T70N) are associated with a hereditary non-neuropathic systemic amyloidosis. These ... [more ▼]

Six variants of human lysozyme (single-point mutations I56T, F57I, W64R, D67H and double mutations F57I/T70N, W112R/T70N) are associated with a hereditary non-neuropathic systemic amyloidosis. These proteins form extracellular amyloid fibrils that deposit in a wide range of tissues and organs such as liver, spleen and kidneys where they cause damages [1]. It was shown that the D67H and I56T mutations cause a loss in stability and more particularly a loss of global cooperativity of protein [1]. Consequently, under physiologically relevant conditions, these variants can transiently populate a partially unfolded state in which the beta-domain and the C-helix are cooperatively unfolded while the rest of the protein remains native like [1]. The formation of intermolecular interactions between the regions that are unfolded in this intermediate state is likely to be a fundamental trigger of the aggregation process that ultimately leads to the formation and deposition of fibrils in tissues. The binding of three variable domain of camelid antibodies – also named nanobodies - (cAb-HuL 6 [2], cAb-HuL 5 and cAb-HuL 22 [3]) raised against the wild type human lysozyme inhibit in vitro the formation of amyloid fibrils by the lysozyme variants. These three nanobodies bind on different regions of lysozyme and act as amyloid fibrils inhibitor through different mechanisms. On one hand, cAb-HuL 6 and cAb-HuL 22 stabilize the native state of the lysozyme variants thus restoring the global cooperativity characteristic of the wild-type protein. On the other, cAb-HuL 5 probably acts by binding soluble prefibrillar aggregates. In the present work, sixteen other nanobodies specific of human lysozyme have been generated. Competition experiments have shown that they bind to five non overlapping epitopes. The effects of the binding of these nanobodies on the stability of the D67H variant of human lysozyme and on its aggregation into amyloid fibrils will be discussed. References [1] Dumoulin et al, (2006) Acc. Chem. Res, 39, 603-610. [2] Dumoulin et al, (2003) Nature, 424, 783-788. [3] Chan et al. (2008) Biochemistry, 47,11041-11054. [less ▲]

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