References of "2010"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailHepatitis C genotype 4 response rate to pegylated interferon and ribavirin treatment in Belgium is similar to genotype 1
de Galocsy, C.; Kaufman, L.; Tomasovic, S. et al

in Acta Gastro-Enterologica Belgica (2010), 73

Background and aims : Patients with genotype 4 (G4) chronic hepatitis C from the Middle East respond better to treatment than genotype 1 (G1) patients. There are few data on the response rates to ... [more ▼]

Background and aims : Patients with genotype 4 (G4) chronic hepatitis C from the Middle East respond better to treatment than genotype 1 (G1) patients. There are few data on the response rates to treatment of G4 patients living in Western Europe. Many G4 patients in Belgium originate from Central Africa, and their response to treatment seems lower. Methods : We analysed the data from 2 randomized phase III studies conducted in Belgium, BerNar-1 and BerNar-2, comparing the sustained virological response (SVR) to pegylated interferon and ribavirin of 78 G4 patients (34 Caucasians, 44 Blacks) and 477 G1 patients (455 Caucasians, 12 Blacks), and assessing the predictors of SVR. Results : Baseline characteristics of G4 and G1 patients were similar except mainly for race. Complete early virological response (cEVR) was similar in G4 (73.2%) and G1 (68.1%). cEVR was also similar between Black and Caucasian G4 and between Black and Caucasian G1 patients. Partial early virological response was similar for G4 and G1. SVR was similar for G4 (51.3%) and G1 (51.8%). There was a trend for a higher SVR in Caucasians than in Blacks. In multivariate analysis, the only predictors for SVR were the presence of cirrhosis, HCV viral load, age < 40 vs 40 yrs, and treatment status (relapsers vs naïve). Conclusions : G4 patients in Belgium have the same SVR as G1 patients. It is lower than the SVR described in Arab countries, especially for Black G4 patients. (Acta gastro enterol. belg., 2010, 73, 229-234). [less ▲]

Detailed reference viewed: 33 (3 ULg)
Full Text
See detailPierre Alechinsky. Récit d’un itinéraire pictural
Bawin, Julie ULg

in Culture, le Magazine Culturel de l'Université de Liège (2010)

Detailed reference viewed: 29 (3 ULg)
Full Text
Peer Reviewed
See detailDiversity of mechanisms involved in aromatase regulation and estrogen action in the brain
Charlier, Thierry ULg; Cornil, Charlotte ULg; Ball, Gregory et al

in Biochimica et Biophysica Acta - General Subjects (2010)

Background In recent years, the mechanisms through which estrogens modulate neuronal physiology, brain morphology, and behavior have proven to be far more complex than previously thought. For example, a ... [more ▼]

Background In recent years, the mechanisms through which estrogens modulate neuronal physiology, brain morphology, and behavior have proven to be far more complex than previously thought. For example, a second nuclear estrogen receptor has been identified, a new family of coregulatory proteins regulating steroid-dependent gene transcriptions was discovered and, finally, it has become clear that estrogens have surprisingly rapid effects based on their actions on cell membranes, which in turn result in the modulation of intracellular signaling cascades. Scope of review This paper presents a selective review of new findings in this area related to work in our laboratories, focusing on the role of estrogens in the activation of male sexual behavior. Two separate topics are considered. We first discuss functions of the steroid receptor coactivator-1 (SRC-1) that has emerged as a key limiting factor for behavioral effects of estradiol. Knocking-down its expression by antisense oligonucleotides drastically inhibits male-typical sexual behaviors. Secondly, we describe rapid regulations of brain estradiol production by calcium-dependent phosphorylations of the aromatase enzyme, themselves under the control of neurotransmitter activity. These rapid changes in estrogen bioavailability have clear behavioral consequences. Increases or decreases in estradiol concentrations respectively obtained by an acute injection of estradiol itself or of an aromatase inhibitor lead within 15–30 min to parallel changes in sexual behavior frequencies. These new controls of estrogen action offer a vast array of possibilities for discrete local controls of estrogen action. They also represent a formidable challenge for neuroendocrinologists trying to obtain an integrated view of brain function in relation to behavior. [less ▲]

Detailed reference viewed: 55 (5 ULg)
Full Text
Peer Reviewed
See detailA survey of honey bee colony losses in Belgium, fall 2008 to spring 2009
Nguyen, Bach Kim ULg; Mignon, Jacques ULg; Laget, D. et al

Conference (2010)

Detailed reference viewed: 76 (21 ULg)
Full Text
Peer Reviewed
See detailJean-Philippe Toussaint
Demoulin, Laurent ULg; Piret, Pierre

in Textyles : Revue des Lettres Belges de Langue Française (2010), 38

L'œuvre de Jean-Philippe Toussaint n'a à ce jour donné lieu à aucune publication monographique en français. Textyles a voulu remédier à cette lacune, en mettant en chantier un numéro pionnier et, à ce ... [more ▼]

L'œuvre de Jean-Philippe Toussaint n'a à ce jour donné lieu à aucune publication monographique en français. Textyles a voulu remédier à cette lacune, en mettant en chantier un numéro pionnier et, à ce titre, résolument ouvert : mettre en perspective les différentes facettes de l’œuvre en multipliant les angles d’approche, tel fut l’objectif qui présida à l’élaboration du présent dossier. Spécialistes des études littéraires, du cinéma et de la photographie s’y côtoient, qui développent des analyses s’attachant à dégager les modes de composition et les principales caractéristiques esthétiques de l’œuvre, à montrer comment elle radiographie les discours contemporains et à la situer dans l’histoire de la littérature. [less ▲]

Detailed reference viewed: 91 (11 ULg)
Full Text
Peer Reviewed
See detailExperimental investigation of the effect of flip bucket splitters on plunge pool geometry
Erpicum, Sébastien ULg; Archambeau, Pierre ULg; Dewals, Benjamin ULg et al

in RWTH - IWW (Ed.) Mitteilungen - 15. Deutsches Talsperrensymposium - Talsperren im Wandel (2010)

Flip buckets are common hydraulic structures aiming at deflecting high velocity flows to a free jet trajectory. Systematic experimental tests have been performed to assess the influence on energy ... [more ▼]

Flip buckets are common hydraulic structures aiming at deflecting high velocity flows to a free jet trajectory. Systematic experimental tests have been performed to assess the influence on energy dissipation and the plunge pool geometry of varied repartitions of splitters along the flip bucket width. In particular, it is shown that some configurations can create more erosion than a continuous channel without flip bucket. [less ▲]

Detailed reference viewed: 38 (5 ULg)
Full Text
Peer Reviewed
See detailLouvre-Lens : Le Louvre autrement : des coulisses aux expositions
Bodéré, Audrey; Drouguet, Noémie ULg

in CeROArt : Conservation, Exposition, Restauration d'Objets d'Art (2010), 5

Detailed reference viewed: 24 (3 ULg)
Full Text
Peer Reviewed
See detailPyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-kappaB activation.
Mortier, Jeremie; Frederick, Raphael; Ganeff, Corinne et al

in Biochemical Pharmacology (2010), 79(10), 1462-72

In this work, we aimed to build a 3D-model of NIK and to study the binding of pyrazolo[4,3-c]isoquinolines with a view to highlight the structural elements responsible for their inhibitory potency ... [more ▼]

In this work, we aimed to build a 3D-model of NIK and to study the binding of pyrazolo[4,3-c]isoquinolines with a view to highlight the structural elements responsible for their inhibitory potency. However, in the course of this work, we unexpectedly found that the pyrazolo[4,3-c]isoquinolines initially reported as NIK inhibitors were neither inhibitors of this enzyme nor of the alternative NF-kappaB pathway, but were in fact inhibitors of another kinase, the TGF-beta activated kinase 1 (TAK1) which is involved in the classical NF-kappaB pathway. [less ▲]

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailDiverse phenotypic profile of uterine tumors resembling ovarian sex cord tumors: an immunohistochemical study of 12 cases.
de Leval, Laurence ULg; Lim, Gkeok Stzuan Diana; Waltregny, David ULg et al

in American Journal of Surgical Pathology (2010), 34(12), 1749-61

BACKGROUND: Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) are rare neoplasms thought to be of putative endometrial stromal origin and solely composed of sex cord elements. Our study aimed ... [more ▼]

BACKGROUND: Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) are rare neoplasms thought to be of putative endometrial stromal origin and solely composed of sex cord elements. Our study aimed to delineate the immunophenotype of these tumors and to verify whether their morphology reflects true sex cord-like differentiation. DESIGN: Representative paraffin blocks from 12 UTROSCTs were selected after confirmation of the diagnosis. Cords and/or trabeculae were seen in all tumors, whereas tubules, diffuse areas, and a retiform pattern were present in 9, 6, and 2 cases, respectively. Tumors were stained for sex cord (inhibin, calretinin, WT1, and melan-A), epithelial (KL1 and epithelial membrane antigen), and smooth muscle markers (smooth muscle actin, desmin, smooth muscle myosin heavy chain, h-caldesmon, and histone deacetylase-8), CD10, HMB45, S100, and CD117. Intensity and percentage of staining were recorded. RESULTS: Six out of 12 tumors were positive for sex cord markers (inhibin 3 of 12, calretinin 4 of 12, WT1 4 of 12, and melan-A 3 of 11) with 4 tumors coexpressing more than one marker. Half of the UTROSCTs showed positivity for KL1, with 2 tumors coexpressing epithelial membrane antigen. All but one tumor expressed one or more smooth muscle markers, with smooth muscle actin, desmin and histone deacetylase-8 being most commonly expressed. CD10 was positive in 6 of 12 tumors, CD117 in 4 of 12, and S100 in 2 of 11 tumors, whereas HMB45 was negative in 11 tumors tested. CONCLUSIONS: UTROSCTs have a diverse immunohistochemical profile often coexpressing sex cord, epithelial, and smooth muscle markers. The expression of smooth muscle markers in these tumors does not imply a smooth muscle origin as endometrial and sex cord stromal tumors are not infrequently positive for these markers. Positivity for sex cord markers supports a true sex cord/steroid phenotype. Although the immunohistochemical profile of these tumors overlaps with that of endometrial stromal tumors with sex cord-like differentiation as well as ovarian sex cord stromal tumors, the origin of UTROSCT remains uncertain. [less ▲]

Detailed reference viewed: 27 (0 ULg)
Full Text
See detailVers une approche moins invasive du traitement chirurgical de l'incontinence urinaire féminine: la voie transoburatrice de dedans en dehors (TVT-O)
Waltregny, David ULg; THOMAS, Alexandre ULg; de Leval, Jean ULg

in Andrologic (2010), 6(5), 1-4

Plusieurs essais randomisés et méta-analyses récentes ont montré que la voie transobturatrice est, à moyen terme, aussi efficace et plus sécurisante que la voie rétropubienne pour la mise en place d’une ... [more ▼]

Plusieurs essais randomisés et méta-analyses récentes ont montré que la voie transobturatrice est, à moyen terme, aussi efficace et plus sécurisante que la voie rétropubienne pour la mise en place d’une bandelette sous-urétrale pour traiter l’incontinence urinaire d’effort (IUE) féminine. En effet, la voie transobturatrice est associée à des taux de guérison subjective de l’IUE similaires (± 85-90%) mais à un risque moindre de saignement, de perforation vésicale et de troubles mictionnels postopératoires. La voie transobturatrice de dedans en dehors (‘Tension-free Vaginal Tape - Obturator’, TVT-O) a été développée en 2003 par Jean de Leval dans le but de réduire le risque de perforation de la vessie et de l’urètre tout en minimisant la dissection chirurgicale nécessaire pour insérer la bandelette. A ce jour, plus de 50 études cliniques, incluant 18 essais randomisés et 3 registres nationaux réalisés en France, Autriche et Norvège, ont largement démontré les excellents résultats à moyen terme (2-5 ans de suivi) de la technique TVT-O. Plus récemment, nous avons apporté deux modifications à la procédure TVT-O, à savoir l’utilisation d’une bandelette plus courte, de 12cm de long, insérée sans perforer la membrane obturatrice par les ciseaux ou le guide. Nos travaux anatomiques sur cadavres ont montré que cette bandelette plus courte est ancrée dans les muscles obturateurs et la membrane obturatrice mais évite dans une large mesure les muscles adducteurs. D’un point de vue clinique, nous avons comparé l’approche TVT-O originale à la version modifiée, potentiellement moins invasive, au travers d’un essai clinique prospectif randomisé. Les résultats de cet essai, présentés au congrès conjoint de l’International Continence Society (ICS) et de l’International Urogynecology Association (IUGA) à Toronto, ont montré qu’après suivi minimal d’1 an, les 2 approches génèrent des taux de guérison de l’IUE élevés et des taux de complications postopératoires très faibles, similaires pour les 2 procédures, la procédure modifiée étant néanmoins associée à une incidence et à une sévérité de douleurs de cuisse postopératoires immédiates significativement moindres. [less ▲]

Detailed reference viewed: 33 (4 ULg)
Peer Reviewed
See detailFollicular fluids, immunological fingerprint and infertility
Lédée, N; Munaut, Carine ULg; PERRIER d'HAUTERIVE, Sophie ULg et al

Conference (2010)

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailMaternal plasma soluble endoglin at 11-13 weeks's gestation in pre-eclampsia
Foidart, Jean-Michel ULg; Munaut, Carine ULg; Chantraine, Frédéric ULg et al

in Ultrasound in Obstetrics & Gynecology (2010), 35(6), 680-7

Objectives: To examine the performance of screening for preeclampsia (PE) by a combination of maternal factors, soluble endoglin (sEng), pregnancy associated plasma protein A (PAPP-A), placental growth ... [more ▼]

Objectives: To examine the performance of screening for preeclampsia (PE) by a combination of maternal factors, soluble endoglin (sEng), pregnancy associated plasma protein A (PAPP-A), placental growth factor (PlGF) and uterine artery lowest pulsatibility index (L-PI) at 11-13 weeks of gestation. Methods: Uterine artery L-PI, sEng, PAPP-A and PlGF were measured at 11-13 weeks in 90 singleton pregnancies that subsequently developed PE, including 30 that required delivery before 34 weeks (early-PE) and 60 with late-PE, and 180 unaffected controls. Screening performance for PE by maternal factors, sEng, PAPP-A, PlGF and uterine artery L-PI and their combinations was determined. Results: In early-PE, compared to controls, plasma sEng and uterine L-PI were significantly increased and serum PAPP-A and PlGF were decreased. In late-PE, compared to controls, serum PlGF was decreased and uterine L-PI was increased but plasma sEng and serum PAPP-A were not significantly different. In screening for early-PE, the detection rate at a 10% false positive rate was 46.7% for sEng alone and 96.3% for a combination of maternal factors, sEng, PlGF and uterine artery L-PI. Conclusions: Effective screening for early-PE can be provided by a combination of maternal factors, sEng, PlGF and uterine artery L-PI at 11-13 weeks. [less ▲]

Detailed reference viewed: 54 (11 ULg)
Full Text
Peer Reviewed
See detailA new type of cubic-stacked layer structure in anthoinite, AlWO3(OH3)
Grey, I.; Madsen, I.; Mills et al

in American Mineralogist (2010), 95

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detailDeletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis.
Docampo Martinez, Elisa ULg; Rabionet, Raquel; Riveira-Munoz, Eva et al

in Arthritis and rheumatism (2010), 62(5), 1246-51

OBJECTIVE: The risk of rheumatoid arthritis (RA) is increased in the offspring of individuals affected with various autoimmune disorders, including psoriasis. Recently, the deletion of 2 genes from the ... [more ▼]

OBJECTIVE: The risk of rheumatoid arthritis (RA) is increased in the offspring of individuals affected with various autoimmune disorders, including psoriasis. Recently, the deletion of 2 genes from the late cornified envelope (LCE) gene cluster, LCE3C and LCE3B, has been associated with psoriasis in several populations. The purpose of this study was to assess whether this polymorphic gene deletion could also be involved in susceptibility to RA. METHODS: We tested for association between the LCE3C_LCE3B copy number variant and a single-nucleotide polymorphism in strong linkage disequilibrium with this variant (rs4112788) and RA in 2 independent case-control data sets (197 and 400 samples from patients with RA, respectively, and 411 and 567 samples from control subjects, respectively), collected at 4 Spanish hospitals. All samples were directly typed for presence of the LCE3C_LCE3B deletion (LCE3C_LCE3B-del) by polymerase chain reaction, and association analysis was performed using the SNPassoc R package. RESULTS: An association of homozygosity for the LCE3C_LCE3B-del and rs4112788 C allele with the risk of RA was observed in the first data set and was replicated in an independent case-control set. A combined analysis showed an overall P value of 0.0012 (odds ratio [OR] 1.45, 95% confidence interval [95% CI] 1.16-1.81) for association of the LCE3C_LCE3B-del. When the analysis was stratified for serologic data, we observed association in anti-cyclic citrullinated peptide (anti-CCP)-positive patients (P = 0.012, OR 1.51 [95% CI 1.09-2.13]) but not in anti-CCP-negative patients. CONCLUSION: We have identified an association between the LCE3C_LCE3B-del and RA, and we have verified a pleiotropic effect of a common genetic risk factor (LCE3C_LCE3B-del) for autoimmune diseases that is involved in both psoriasis and RA. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailMicroRNAs in the tumor endothelium: novel controls on the angioregulatory switchboard
Heusschen, Roy ULg; van Gink, Matthijs; Griffioen, Arjan et al

in Biochimica et Biophysica Acta - Reviews on Cancer (2010), 1805

Detailed reference viewed: 6 (1 ULg)