References of "2010"
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See detailPierre Alechinsky. Récit d’un itinéraire pictural
Bawin, Julie ULg

in Culture, le Magazine Culturel de l'Université de Liège (2010)

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See detailA survey of honey bee colony losses in Belgium, fall 2008 to spring 2009
Nguyen, Bach Kim ULg; Mignon, Jacques ULg; Laget, D. et al

Conference (2010)

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See detailDiversity of mechanisms involved in aromatase regulation and estrogen action in the brain
Charlier, Thierry ULg; Cornil, Charlotte ULg; Ball, Gregory et al

in Biochimica et Biophysica Acta - General Subjects (2010)

Background In recent years, the mechanisms through which estrogens modulate neuronal physiology, brain morphology, and behavior have proven to be far more complex than previously thought. For example, a ... [more ▼]

Background In recent years, the mechanisms through which estrogens modulate neuronal physiology, brain morphology, and behavior have proven to be far more complex than previously thought. For example, a second nuclear estrogen receptor has been identified, a new family of coregulatory proteins regulating steroid-dependent gene transcriptions was discovered and, finally, it has become clear that estrogens have surprisingly rapid effects based on their actions on cell membranes, which in turn result in the modulation of intracellular signaling cascades. Scope of review This paper presents a selective review of new findings in this area related to work in our laboratories, focusing on the role of estrogens in the activation of male sexual behavior. Two separate topics are considered. We first discuss functions of the steroid receptor coactivator-1 (SRC-1) that has emerged as a key limiting factor for behavioral effects of estradiol. Knocking-down its expression by antisense oligonucleotides drastically inhibits male-typical sexual behaviors. Secondly, we describe rapid regulations of brain estradiol production by calcium-dependent phosphorylations of the aromatase enzyme, themselves under the control of neurotransmitter activity. These rapid changes in estrogen bioavailability have clear behavioral consequences. Increases or decreases in estradiol concentrations respectively obtained by an acute injection of estradiol itself or of an aromatase inhibitor lead within 15–30 min to parallel changes in sexual behavior frequencies. These new controls of estrogen action offer a vast array of possibilities for discrete local controls of estrogen action. They also represent a formidable challenge for neuroendocrinologists trying to obtain an integrated view of brain function in relation to behavior. [less ▲]

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See detailDo clinical factors help to predict disease course in inflammatory bowel disease?
Louis, Edouard ULg; Belaiche, Jacques ULg; Reenaers, Catherine ULg

in World Journal of Gastroenterology (2010), 16(21), 2600-3

While therapeutic strategies able to change the natural history of the disease are developing, it is of major importance to have available predictive factors for aggressive disease to try and target these ... [more ▼]

While therapeutic strategies able to change the natural history of the disease are developing, it is of major importance to have available predictive factors for aggressive disease to try and target these therapeutic strategies. Clinical predictors have probably been the most broadly studied. In both Crohn's disease (CD) and ulcerative colitis (UC), age at diagnosis, disease location and smoking habit are currently the strongest predictors of disease course. A younger age at onset is associated with more aggressive disease both in CD and UC. Disease location in CD is associated with different types of complications: surgery and recurrence in upper gastrointestinal and proximal small bowel disease; and surgery in distal small bowel disease and peri-anal lesions in rectal disease. In UC, extensive colitis is clearly been associated with more severe disease. Finally, active smoking globally increases disease severity in CD but decreases it in UC. Besides these important factors, others may predispose to some specific disease evolution and complications, and are also reviewed in the present paper. [less ▲]

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See detailFollicular fluids, immunological fingerprint and infertility
Lédée, N; Munaut, Carine ULg; PERRIER d'HAUTERIVE, Sophie ULg et al

Conference (2010)

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See detailMaternal plasma soluble endoglin at 11-13 weeks's gestation in pre-eclampsia
Foidart, Jean-Michel ULg; Munaut, Carine ULg; Chantraine, Frédéric ULg et al

in Ultrasound in Obstetrics & Gynecology (2010), 35(6), 680-7

Objectives: To examine the performance of screening for preeclampsia (PE) by a combination of maternal factors, soluble endoglin (sEng), pregnancy associated plasma protein A (PAPP-A), placental growth ... [more ▼]

Objectives: To examine the performance of screening for preeclampsia (PE) by a combination of maternal factors, soluble endoglin (sEng), pregnancy associated plasma protein A (PAPP-A), placental growth factor (PlGF) and uterine artery lowest pulsatibility index (L-PI) at 11-13 weeks of gestation. Methods: Uterine artery L-PI, sEng, PAPP-A and PlGF were measured at 11-13 weeks in 90 singleton pregnancies that subsequently developed PE, including 30 that required delivery before 34 weeks (early-PE) and 60 with late-PE, and 180 unaffected controls. Screening performance for PE by maternal factors, sEng, PAPP-A, PlGF and uterine artery L-PI and their combinations was determined. Results: In early-PE, compared to controls, plasma sEng and uterine L-PI were significantly increased and serum PAPP-A and PlGF were decreased. In late-PE, compared to controls, serum PlGF was decreased and uterine L-PI was increased but plasma sEng and serum PAPP-A were not significantly different. In screening for early-PE, the detection rate at a 10% false positive rate was 46.7% for sEng alone and 96.3% for a combination of maternal factors, sEng, PlGF and uterine artery L-PI. Conclusions: Effective screening for early-PE can be provided by a combination of maternal factors, sEng, PlGF and uterine artery L-PI at 11-13 weeks. [less ▲]

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See detailMieux comprendre le savoir-agir autonome - Développement et analyse d'usages d'un environnement d'apprentissage destiné aux élèves de 10 à 15 ans
Georges, François ULg

Doctoral thesis (2010)

Analyse du potentiel autonomisant d'un environnement d'apprentissage en ligne destiné aux élèves de 10 à 15 ans

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See detailDeletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis.
Docampo Martinez, Elisa ULg; Rabionet, Raquel; Riveira-Munoz, Eva et al

in Arthritis and rheumatism (2010), 62(5), 1246-51

OBJECTIVE: The risk of rheumatoid arthritis (RA) is increased in the offspring of individuals affected with various autoimmune disorders, including psoriasis. Recently, the deletion of 2 genes from the ... [more ▼]

OBJECTIVE: The risk of rheumatoid arthritis (RA) is increased in the offspring of individuals affected with various autoimmune disorders, including psoriasis. Recently, the deletion of 2 genes from the late cornified envelope (LCE) gene cluster, LCE3C and LCE3B, has been associated with psoriasis in several populations. The purpose of this study was to assess whether this polymorphic gene deletion could also be involved in susceptibility to RA. METHODS: We tested for association between the LCE3C_LCE3B copy number variant and a single-nucleotide polymorphism in strong linkage disequilibrium with this variant (rs4112788) and RA in 2 independent case-control data sets (197 and 400 samples from patients with RA, respectively, and 411 and 567 samples from control subjects, respectively), collected at 4 Spanish hospitals. All samples were directly typed for presence of the LCE3C_LCE3B deletion (LCE3C_LCE3B-del) by polymerase chain reaction, and association analysis was performed using the SNPassoc R package. RESULTS: An association of homozygosity for the LCE3C_LCE3B-del and rs4112788 C allele with the risk of RA was observed in the first data set and was replicated in an independent case-control set. A combined analysis showed an overall P value of 0.0012 (odds ratio [OR] 1.45, 95% confidence interval [95% CI] 1.16-1.81) for association of the LCE3C_LCE3B-del. When the analysis was stratified for serologic data, we observed association in anti-cyclic citrullinated peptide (anti-CCP)-positive patients (P = 0.012, OR 1.51 [95% CI 1.09-2.13]) but not in anti-CCP-negative patients. CONCLUSION: We have identified an association between the LCE3C_LCE3B-del and RA, and we have verified a pleiotropic effect of a common genetic risk factor (LCE3C_LCE3B-del) for autoimmune diseases that is involved in both psoriasis and RA. [less ▲]

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See detailLow-molecular-weight heparin dosage in newborn foals.
Armengou, L.; Monreal, L.; Delgado, M. A. et al

in Journal of veterinary internal medicine / American College of Veterinary Internal Medicine (2010), 24(5), 1190-5

BACKGROUND: Heparin is used in humans as prophylaxis of hypercoagulable states and disseminated intravascular coagulation (DIC). However, babies need a higher heparin dose than do adults. Septic neonate ... [more ▼]

BACKGROUND: Heparin is used in humans as prophylaxis of hypercoagulable states and disseminated intravascular coagulation (DIC). However, babies need a higher heparin dose than do adults. Septic neonate foals are at high risk of hypercoagulable state and DIC, and there is limited objective information about heparin dose for equine neonates. OBJECTIVE: To assess whether neonate foals require higher dosages of low-molecular-weight heparin (LMWH) than adults. ANIMALS: Eighteen healthy and 11 septic neonate foals. METHODS: Experimental and clinical studies. Firstly, healthy foals were randomly distributed in 2 groups, 1 receiving 50 IU/kg SC of dalteparin and the 2nd group receiving 100 IU/kg SC of dalteparin, once daily for 3 days. Blood samples were collected before and 3, 6, 27, and 51 hours after the 1st LMWH administration. Plasma antifactor-Xa activity was measured, together with hemostatic and hematologic parameters used to assess the risk of bleeding. Subsequently, septic foals were treated blindly either with placebo (saline) or 100 IU/kg of dalteparin for 3 days. Plasma antifactor-Xa activity and other hemostatic parameters were determined before and after treatment. RESULTS: Plasma antifactor-Xa activity in healthy foals was below prophylactic activity when using the adult dosage (50 IU/kg), whereas prophylactic activities were achieved when using the double dosage (100 IU/kg). No hemorrhagic events and erythrocyte-related complications were observed with either dosage. In the clinical study, only 4/6 septic foals had plasma antifactor-Xa activity adequate for prophylaxis. CONCLUSIONS AND CLINICAL IMPORTANCE: Equine neonates require higher dosages of LMWH compared with adults to reach prophylactic heparinemia. [less ▲]

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See detailWhich rules shape EU's external governance? The patterns of rule selection in foreign and security policies
Barbé, Esther; Costa, Oriol; Herranz-Surrallés, Anna et al

in Lavenex, Sandra; Schimmelfennig, Frank (Eds.) EU External Governance: Projecting EU Rules beyond Membership (2010)

This article addresses a particular aspect of EU external governance: rule selection. Drawing on institutionalist and power-based explanations we put forward an account for the choice of the specific ... [more ▼]

This article addresses a particular aspect of EU external governance: rule selection. Drawing on institutionalist and power-based explanations we put forward an account for the choice of the specific rules that guide policy convergence between the EU and third countries. The proposed analytical framework broadens the scope of the studies examining the externalization of EU rules beyond its borders, in that we claim that the EU can promote policy convergence using rules other than the EU's. More specifically, the EU also promotes policy convergence on the basis of international and bilaterally developed rules. These analytical claims for explaining rule selection are checked against empirical data. We compare policy convergence between the EU and four neighbouring countries (Morocco, Ukraine, Georgia, and Russia) in three subfields within foreign and security policy: foreign policy dialogue, control of export of dual-use goods in the context of non-proliferation of weapons of mass destruction, and crisis management. [less ▲]

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See detailL’édition pour la jeunesse en Belgique francophone : de la nécessité faite vertu à la mondialisation
Habrand, Tanguy ULg

in Pinhas, Luc; Foucault, Jean; Manson, Michel (Eds.) L'édition de jeunesse francophone face à la mondialisation (2010)

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See detailIntroduction : migration and ethnic studies in Europe
Martiniello, Marco ULg; Rath, Jan

in Martiniello, Marco; Rath, Jan (Eds.) Selected Studies in International Migration and Immigrant Incorporation (2010)

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See detailLes défis du droit romain et du droit privé comparé
Gerkens, Jean-François ULg

in Gosselin, Antoinette; Langevin, Caroline; Wautelet, Patrick (Eds.) L'avenir de la recherche: Réflexions à l'occasion des leçons inaugurales 2010 (2010)

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See detailLe cycle de Guillaume d’Orange ou les Aliscans rajeunis
Henrard, Nadine ULg

in Cazanave, Caroline; Houssais, Yvon (Eds.) Grands textes du Moyen Âge à l'usage des petits (2010)

Examen d'une douzaine de versions de récritures de la geste de Guillaume d'Orange parues entre 1905 et 1995 et destinées à la jeunesse

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See detailManaging climatic risks for enhanced food security : key information capabilities
Balaghi, Riad; Badjeck, M.-C.; Djaby, Bakary ULg et al

in Procedia Environmental Sciences (2010), 1

Food security is expected to face increasing challenges from climatic risks that are more and more exacerbated by climate change, especially in the developing world. This document lists some of the main ... [more ▼]

Food security is expected to face increasing challenges from climatic risks that are more and more exacerbated by climate change, especially in the developing world. This document lists some of the main capabilities that have been recently developed, especially in the area of operational agroclimatology, for an efficient use of natural resources and a better management of climatic risks. Many countries, including the developing world, now benefit from well-trained staff in the use of climate data, physical and biological information and knowledge to reduce negative climate impacts. A significant volume of data and knowledge about climate–agriculture relationships is now available and used by students, scientists, technicians, agronomists, decision-makers and farmers alike, particularly in the areas of climate characterization, land suitability and agroecological zoning, seasonal climate forecasts, drought early warning systems and operational crop forecasting systems. Climate variability has been extensively modelled, capturing important features of the climate through applied statistical procedures, agroclimatic indices derived from raw climatic data and from remote sensing. Predictions of climate at seasonal to interannual timescales are helping decision-makers in the agricultural sector to deal more effectively with the effects of climate variability. Land suitability and agroclimatic zoning have been used in many countries for agricultural planning, thanks to the availability of new and comprehensive methodologies; developments in climate, soil and remote sensing data collection and analysis; and improved applications in geographic information systems (GIS). Drought early warning systems are available worldwide at both national and international levels. These systems are helping decisionmakers and farmers to take appropriate decisions to adapt to short-term climatic risks. Also, operational crop forecasting systems are now becoming available at the regional and national levels. In some developed countries, several efficient and well tested tools are now available for optimizing on-farm decisions based on the combination of crop simulation models and seasonal forecasts. However, in developing countries few tools have been developed to efficiently manage crops at the farm level to cope with climate variability and climate risks. Climate change impacts on agriculture and food security have been assessed in international studies using specific and efficient methodologies and tools. Adaptation to climate change and variability can also be facilitated through effective planning and implementation of strategies at the political level. The role of technological progress, risk transfer mechanisms and financial instruments and their easy accessibility to rural people are critical elements of climate risk management. [less ▲]

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See detailSignspeak--understanding, recognition, and translation of sign languages
Dreuw, Philippe; Forster, Jens; Gweth, Yannick et al

in 4th Workshop on the Representation and Processing of Sign Languages: Corpora and Sign Language Technologies (2010)

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See detailLes nouveaux défis de l'enseignement du français langue étrangère en Europe
Defays, Jean-Marc ULg

in Dialogues et Cultures (2010), 56

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