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See detailSevere skin lesions cause patients with inflammatory bowel disease to discontinue anti-tumor necrosis factor therapy.
Rahier, Jean*-Francois; Buche, Sebastien; Peyrin-Biroulet, Laurent et al

in Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of The American Gastroenterological Association (2010), 8(12), 1048-55

BACKGROUND & AIMS: Psoriasiform and eczematiform lesions are associated with anti-tumor necrosis factor (TNF)-alpha therapies. We assessed clinical characteristics, risk factors, and outcomes of skin ... [more ▼]

BACKGROUND & AIMS: Psoriasiform and eczematiform lesions are associated with anti-tumor necrosis factor (TNF)-alpha therapies. We assessed clinical characteristics, risk factors, and outcomes of skin disease in patients with inflammatory bowel diseases that presented with psoriasiform and eczematiform lesions induced by anti-TNF-alpha agents. METHODS: We studied 85 patients (69 with Crohn's disease, 15 with ulcerative colitis, and 1 with indeterminate colitis; 62 women) with inflammatory skin lesions (62 psoriasiform and 23 eczematiform lesions). RESULTS: Twenty-four patients had a history of inflammatory skin lesions and 15 had a familial history of inflammatory skin disease. Locations of eczematiform lesions varied whereas scalp and flexural varieties were mostly psoriasiform. Skin lesions emerged but inflammatory bowel disease was quiescent in 69 patients following treatment with any type of anti-TNF-alpha agent (60 with infliximab, 20 with adalimumab, and 5 with certolizumab). Topical therapy resulted in partial or total remission in 41 patients. Patients with psoriasiform lesions that were resistant to topical therapy and that changed anti-TNF-alpha therapies once or twice developed recurring lesions. Overall, uncontrolled skin lesions caused 29 patients to stop taking TNF-alpha inhibitors. CONCLUSIONS: Inflammatory skin lesions following therapy with TNF-alpha inhibitors occurred most frequently among women and patients with a personal or familial history of inflammatory skin disease; lesions did not correlate with intestinal disease activity. Recurring and intense skin lesions caused 34% of patients in this study to discontinue use of anti-TNF-alpha agents. [less ▲]

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See detailDo clinical factors help to predict disease course in inflammatory bowel disease?
Louis, Edouard ULg; Belaiche, Jacques ULg; Reenaers, Catherine ULg

in World Journal of Gastroenterology (2010), 16(21), 2600-3

While therapeutic strategies able to change the natural history of the disease are developing, it is of major importance to have available predictive factors for aggressive disease to try and target these ... [more ▼]

While therapeutic strategies able to change the natural history of the disease are developing, it is of major importance to have available predictive factors for aggressive disease to try and target these therapeutic strategies. Clinical predictors have probably been the most broadly studied. In both Crohn's disease (CD) and ulcerative colitis (UC), age at diagnosis, disease location and smoking habit are currently the strongest predictors of disease course. A younger age at onset is associated with more aggressive disease both in CD and UC. Disease location in CD is associated with different types of complications: surgery and recurrence in upper gastrointestinal and proximal small bowel disease; and surgery in distal small bowel disease and peri-anal lesions in rectal disease. In UC, extensive colitis is clearly been associated with more severe disease. Finally, active smoking globally increases disease severity in CD but decreases it in UC. Besides these important factors, others may predispose to some specific disease evolution and complications, and are also reviewed in the present paper. [less ▲]

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See detailModeling of a Magnetic Shunt and an Aluminum Screen Using the Perturbation Finite Element Method
Ferreira da Luz, Mauricio V.; Dular, Patrick ULg; V Sabariego, Ruth ULg et al

in Proceedings of the 14th Biennial IEEE Conference on Electromagnetic Field Computation (CEFC2010) (2010)

In this paper the perturbation technique is developed for modeling of the magnetic shunt and an aluminum screen in large power transformers. The problem is first studied using either a simplified ... [more ▼]

In this paper the perturbation technique is developed for modeling of the magnetic shunt and an aluminum screen in large power transformers. The problem is first studied using either a simplified analytical or a finite element model. A more elaborated model is then defined to take into account its structural details. The calculation of iron losses and of the minimum clearance between bus bars leading current and magnetizable steel parts for a frequency range is performed. The modeling takes into account the eddy currents in magnetic shunt laminations due to the magnetic field in the shunt. [less ▲]

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See detailRedistribution of fibrillarin following treatment of human bladder carcinoma cells with aptatone
Jamison, James; Gilloteaux, Jacques; Perlaky, L et al

Poster (2010)

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See detailFollicular fluids, immunological fingerprint and infertility
Lédée, N; Munaut, Carine ULg; PERRIER d'HAUTERIVE, Sophie ULg et al

Conference (2010)

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See detailMaternal plasma soluble endoglin at 11-13 weeks's gestation in pre-eclampsia
Foidart, Jean-Michel ULg; Munaut, Carine ULg; Chantraine, Frédéric ULg et al

in Ultrasound in Obstetrics & Gynecology (2010), 35(6), 680-7

Objectives: To examine the performance of screening for preeclampsia (PE) by a combination of maternal factors, soluble endoglin (sEng), pregnancy associated plasma protein A (PAPP-A), placental growth ... [more ▼]

Objectives: To examine the performance of screening for preeclampsia (PE) by a combination of maternal factors, soluble endoglin (sEng), pregnancy associated plasma protein A (PAPP-A), placental growth factor (PlGF) and uterine artery lowest pulsatibility index (L-PI) at 11-13 weeks of gestation. Methods: Uterine artery L-PI, sEng, PAPP-A and PlGF were measured at 11-13 weeks in 90 singleton pregnancies that subsequently developed PE, including 30 that required delivery before 34 weeks (early-PE) and 60 with late-PE, and 180 unaffected controls. Screening performance for PE by maternal factors, sEng, PAPP-A, PlGF and uterine artery L-PI and their combinations was determined. Results: In early-PE, compared to controls, plasma sEng and uterine L-PI were significantly increased and serum PAPP-A and PlGF were decreased. In late-PE, compared to controls, serum PlGF was decreased and uterine L-PI was increased but plasma sEng and serum PAPP-A were not significantly different. In screening for early-PE, the detection rate at a 10% false positive rate was 46.7% for sEng alone and 96.3% for a combination of maternal factors, sEng, PlGF and uterine artery L-PI. Conclusions: Effective screening for early-PE can be provided by a combination of maternal factors, sEng, PlGF and uterine artery L-PI at 11-13 weeks. [less ▲]

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See detailInfluence of veneer thickness on residual stresses in zirconia prostheses.
Mainjot, Amélie ULg; Schajer, Gary; Vanheusden, Alain ULg et al

in Dental Materials (2010)

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See detailDeletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis.
Docampo Martinez, Elisa ULg; Rabionet, Raquel; Riveira-Munoz, Eva et al

in Arthritis and rheumatism (2010), 62(5), 1246-51

OBJECTIVE: The risk of rheumatoid arthritis (RA) is increased in the offspring of individuals affected with various autoimmune disorders, including psoriasis. Recently, the deletion of 2 genes from the ... [more ▼]

OBJECTIVE: The risk of rheumatoid arthritis (RA) is increased in the offspring of individuals affected with various autoimmune disorders, including psoriasis. Recently, the deletion of 2 genes from the late cornified envelope (LCE) gene cluster, LCE3C and LCE3B, has been associated with psoriasis in several populations. The purpose of this study was to assess whether this polymorphic gene deletion could also be involved in susceptibility to RA. METHODS: We tested for association between the LCE3C_LCE3B copy number variant and a single-nucleotide polymorphism in strong linkage disequilibrium with this variant (rs4112788) and RA in 2 independent case-control data sets (197 and 400 samples from patients with RA, respectively, and 411 and 567 samples from control subjects, respectively), collected at 4 Spanish hospitals. All samples were directly typed for presence of the LCE3C_LCE3B deletion (LCE3C_LCE3B-del) by polymerase chain reaction, and association analysis was performed using the SNPassoc R package. RESULTS: An association of homozygosity for the LCE3C_LCE3B-del and rs4112788 C allele with the risk of RA was observed in the first data set and was replicated in an independent case-control set. A combined analysis showed an overall P value of 0.0012 (odds ratio [OR] 1.45, 95% confidence interval [95% CI] 1.16-1.81) for association of the LCE3C_LCE3B-del. When the analysis was stratified for serologic data, we observed association in anti-cyclic citrullinated peptide (anti-CCP)-positive patients (P = 0.012, OR 1.51 [95% CI 1.09-2.13]) but not in anti-CCP-negative patients. CONCLUSION: We have identified an association between the LCE3C_LCE3B-del and RA, and we have verified a pleiotropic effect of a common genetic risk factor (LCE3C_LCE3B-del) for autoimmune diseases that is involved in both psoriasis and RA. [less ▲]

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See detailMicroRNAs in the tumor endothelium: novel controls on the angioregulatory switchboard
Heusschen, Roy ULg; van Gink, Matthijs; Griffioen, Arjan et al

in Biochimica et Biophysica Acta - Reviews on Cancer (2010), 1805

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See detailHet nieuwe echtscheidingsrecht: volgzaam en toch vooruitstrevend
Leleu, Yves-Henri ULg

in Verschelden, G. (Ed.) Echtscheiding (2010)

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See detailWhich rules shape EU's external governance? The patterns of rule selection in foreign and security policies
Barbé, Esther; Costa, Oriol; Herranz-Surrallés, Anna et al

in Lavenex, Sandra; Schimmelfennig, Frank (Eds.) EU External Governance: Projecting EU Rules beyond Membership (2010)

This article addresses a particular aspect of EU external governance: rule selection. Drawing on institutionalist and power-based explanations we put forward an account for the choice of the specific ... [more ▼]

This article addresses a particular aspect of EU external governance: rule selection. Drawing on institutionalist and power-based explanations we put forward an account for the choice of the specific rules that guide policy convergence between the EU and third countries. The proposed analytical framework broadens the scope of the studies examining the externalization of EU rules beyond its borders, in that we claim that the EU can promote policy convergence using rules other than the EU's. More specifically, the EU also promotes policy convergence on the basis of international and bilaterally developed rules. These analytical claims for explaining rule selection are checked against empirical data. We compare policy convergence between the EU and four neighbouring countries (Morocco, Ukraine, Georgia, and Russia) in three subfields within foreign and security policy: foreign policy dialogue, control of export of dual-use goods in the context of non-proliferation of weapons of mass destruction, and crisis management. [less ▲]

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See detailThe umbilical cord matrix is a better source of mesenchymal stem cells (MSC) than the umbilical cord blood.
Zeddou, Mustapha ULg; Briquet, Alexandra ULg; Relic, Biserka ULg et al

in Cell Biology International (2010), 34(7), 693-701

Many studies have drawn attention to the emerging role of MSC (mesenchymal stem cells) as a promising population supporting new clinical concepts in cellular therapy. However, the sources from which these ... [more ▼]

Many studies have drawn attention to the emerging role of MSC (mesenchymal stem cells) as a promising population supporting new clinical concepts in cellular therapy. However, the sources from which these cells can be isolated are still under discussion. Whereas BM (bone marrow) is presented as the main source of MSC, despite the invasive procedure related to this source, the possibility of isolating sufficient numbers of these cells from UCB (umbilical cord blood) remains controversial. Here, we present the results of experiments aimed at isolating MSC from UCB, BM and UCM (umbilical cord matrix) using different methods of isolation and various culture media that summarize the main procedures and criteria reported in the literature. Whereas isolation of MSC were successful from BM (10:10) and (UCM) (8:8), only one cord blood sample (1:15) gave rise to MSC using various culture media [DMEM (Dulbecco's modified Eagle's medium) +5% platelet lysate, DMEM+10% FBS (fetal bovine serum), DMEM+10% human UCB serum, MSCGM] and different isolation methods [plastic adherence of total MNC (mononuclear cells), CD3+/CD19+/CD14+/CD38+-depleted MNC and CD133+- or LNGFR+-enriched MNC]. MSC from UCM and BM were able to differentiate into adipocytes, osteocytes and hepatocytes. The expansion potential was highest for MSC from UCM. The two cell populations had CD90+/CD73+/CD105+ phenotype with the additional expression of SSEA4 and LNGFR for BM MSC. These results clearly exclude UCB from the list of MSC sources for clinical use and propose instead UCM as a rich, non-invasive and abundant source of MSC. [less ▲]

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See detailQuels enseignements tirer des données de délinquance auto-révélées?
Gavray, Claire ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (2010)

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See detailHetero Diels-Alder (HDA) reactions of 1-phosphono-1,3-butadienes with azo and nitroso dienophiles : an entry towards versatile heterocyclic synthons for aminophosphonic compounds
Monbaliu, Jean-Christophe ULg; Villemin, Elise; Elias, Benjamin et al

in Attanasi, Orazio (Ed.) Targets in heterocyclic systems - Chemistry and Properties (2010)

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See detailIMA Commission on New Minerals, Nomenclature and Classification (CNMNC), Newsletter 5
Williams, Pete; Hatert, Frédéric ULg; Pasero, Marco et al

in Mineralogical Magazine (2010), 74(5), 899-902

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See detailSignspeak--understanding, recognition, and translation of sign languages
Dreuw, Philippe; Forster, Jens; Gweth, Yannick et al

in 4th Workshop on the Representation and Processing of Sign Languages: Corpora and Sign Language Technologies (2010)

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See detailIntroduction to Electromechanical Coupling
Rochus, Véronique ULg

in Computer and Experimental Simulations in Engineering and Science [=CESES] (2010), (7),

This paper is dedicated to the physical understanding of electrostatic forces with a one-dimensional reference problem. First a non-dimensional analysis prescribes the kind of assumptions to consider for ... [more ▼]

This paper is dedicated to the physical understanding of electrostatic forces with a one-dimensional reference problem. First a non-dimensional analysis prescribes the kind of assumptions to consider for the electric field model. An analytical study of electro-mechanical coupling is then performed to understand the type of non-linearity added by electrostatic forces, and static and dynamic analysis are used to define new characteristic parameters. To come closer to more realistic problems, cubic mechanical stiffness is added to account for the large displacement hypothesis prescribed for certain types of MEMS and damping effects are studied. [less ▲]

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