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See detailEffect of macronutrient ratio of the pre-starter diet on broiler performance and intermediary metabolism.
Swennen, Q.; Everaert, Nadia ULg; Debonne, M. et al

in Journal of Animal Physiology & Animal Nutrition (2010), 94(3), 375-84

The aim of this study was to investigate the influence of isoenergetic substitution between the three energy delivering macronutrients in pre-starter diets on performance and intermediary nutrient ... [more ▼]

The aim of this study was to investigate the influence of isoenergetic substitution between the three energy delivering macronutrients in pre-starter diets on performance and intermediary nutrient metabolism in broiler chickens. From hatch until 5 days of age, 600 chicks, collected during peak of hatch, were fed one of the three experimental pre-starter diets with isoenergetic (13 MJ metabolisable energy/kg) substitutions between fat (43 vs. 108 g/kg), protein (126 vs. 240 g/kg) and carbohydrates (391 vs. 510 g/kg). After 5 days, commercial grower and finisher diets were provided. Pre-starter composition influenced body weight until slaughter age, although not statistically verifiable. Broilers fed the low protein (LP) pre-starter had the lowest body weight in relation to chickens on the low carbohydrate or low fat pre-starter diet. After hatch, chicks on the LP pre-starter diet were able to use the residual yolk sac more rapidly to fulfil their protein requirement, which is reflected in small intestine and liver development. Also, plasma metabolite levels were influenced mostly by the LP pre-starter, indicating that the main focus for the requirements of newly hatched chicks should be on proteins. Furthermore, optimal nutrition during the first day's post-hatch should take into account the contribution of the yolk. [less ▲]

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See detailL'etude clinique du mois. ACCORD-LIPID et ACCORD-EYE: vers un nouveau positionnement du fenofibrate chez le patient diabetique de type 2.
Scheen, André ULg; Van Gaal, L. F.

in Revue Médicale de Liège (2010), 65(9), 533-9

Fenofibrate has been evaluated in the ACCORD trial, in combination with a statin, to prevent vascular complications in patients with type 2 diabetes. In ACCORD-Lipid, the addition of fenofibrate was not ... [more ▼]

Fenofibrate has been evaluated in the ACCORD trial, in combination with a statin, to prevent vascular complications in patients with type 2 diabetes. In ACCORD-Lipid, the addition of fenofibrate was not able to significantly reduce the incidence of a composite cardiovascular endpoint (no positive effect was also observed with the intensification of blood glucose or blood pressure control in this population). However, an interaction effect was observed according to basal lipid profile, suggesting a better protection by fenofibrate in patients with hypertriglyceridaemia and low HDL cholesterol (so-called atherogenic dyslipidaemia). In ACCORD-Eye, the addition of fenofibrate to a basal statin therapy resulted in a significant reduction of the progression of diabetic retinopathy, in a similar manner as that observed with intensifying blood glucose control (but with a good safety profile and without increasing the risk of hypoglycaemia). These observations, confirming earlier results from FIELD also with this fibrate, open new perspectives for a useful prescription of fenofibrate in patients with type 2 diabetes. [less ▲]

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See detailIncidence of sport injuries in elite young athletes of the Grand-duchy of Luxembourg
Frisch, Anne ULg; Urhausen, A.; Seil et al

in Buys, R.; Buerkers, M.; Daly, D. (Eds.) Programma boek final of the 12th International ACAPS Conference (2010)

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See detailLa motivations des arrêts de la cour d'assises et son contrôle.
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2010), 10/450(36), 1719

Observations sur l'arrêt de la Cour de cassation cassant les arrêts attaqués rendus le 12 février 2010, sous les n° 7 et 8 du répertoire, par la cour d'assises de la province de Namur

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See detailExperimental investigation of the effect of flip bucket splitters on plunge pool geometry
Erpicum, Sébastien ULg; Archambeau, Pierre ULg; Dewals, Benjamin ULg et al

in RWTH - IWW (Ed.) Mitteilungen - 15. Deutsches Talsperrensymposium - Talsperren im Wandel (2010)

Flip buckets are common hydraulic structures aiming at deflecting high velocity flows to a free jet trajectory. Systematic experimental tests have been performed to assess the influence on energy ... [more ▼]

Flip buckets are common hydraulic structures aiming at deflecting high velocity flows to a free jet trajectory. Systematic experimental tests have been performed to assess the influence on energy dissipation and the plunge pool geometry of varied repartitions of splitters along the flip bucket width. In particular, it is shown that some configurations can create more erosion than a continuous channel without flip bucket. [less ▲]

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See detailComment j’explore ... une masse rétropéritonéale chez l’enfant
Malaise, Olivier ULg; Vandenbosch, Kristel ULg; Uyttebroeck, Anna et al

in Revue Médicale de Liège (2010), 65(3), 156-162

Detection of a retroperitoneal mass in children needs a fast and accurate exploration. Wilms tumor and neuroblastoma, the most frequent, will be presented more in detail including their clinical and ... [more ▼]

Detection of a retroperitoneal mass in children needs a fast and accurate exploration. Wilms tumor and neuroblastoma, the most frequent, will be presented more in detail including their clinical and biological characteristics, their diagnostic tests and their primary therapeutic treatments. [less ▲]

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See detailReduction du risque metabolique associe a l'obesite en modulant l'exposition tissulaire au cortisol.
Iovino, Alessandra ULg; Paquot, Nicolas ULg; Scheen, André ULg

in Revue Médicale Suisse (2010), 6(260), 1608-12

The 11-beta-hydroxysteroid dehydrogenase type 1 (11HSD1) enzyme promotes the local conversion from cortisone to cortisol, especially in the liver and the adipose tissue. It may play a role in the ... [more ▼]

The 11-beta-hydroxysteroid dehydrogenase type 1 (11HSD1) enzyme promotes the local conversion from cortisone to cortisol, especially in the liver and the adipose tissue. It may play a role in the pathophysiology of abdominal obesity and the metabolic syndrome, both showing some similarities with the Cushing syndrome. Considering experimental results obtained in rodents, the inhibition of this enzyme could exert favourable metabolic effects, with significant reductions in plasma glucose, insulin resistance and dyslipidaemia. Synthetic inhibitors of 11HSD1 are currently in development with encouraging preliminary results, first in animals, and more recently in humans. Selective inhibitors of 11HSD1 may represent an innovative approach in the pharmacological management of obesity, metabolic syndrome and type 2 diabetes in a near future. [less ▲]

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See detailBuilding the quality into pellet manufacturing environment - feasibility study and validation of an in-line quantitative near infrared (NIR) method
Mantanus, Jérôme ULg; Ziemons, Eric ULg; Rozet, Eric ULg et al

in Talanta (2010), 83

The present study focuses on the implementation of an in-line quantitative near infrared (NIR) spectroscopic method for determining the active content of pharmaceutical pellets. The first aim was to non ... [more ▼]

The present study focuses on the implementation of an in-line quantitative near infrared (NIR) spectroscopic method for determining the active content of pharmaceutical pellets. The first aim was to non-invasively interface a dispersive NIR spectrometer with four realistic particle streams existing in the pellets manufacturing environment. Regardless of the particle stream characteristics investigated, NIR together with principal component analysis (PCA) was able to classify the samples according to their active content. Further, one of these particle stream interfaces was non-invasively investigated with a FT-NIR spectrometer. A predictive model based on Partial Least Squares (PLS) regression was able to determine the active content of pharmaceutical pellets. The NIR method was finally validated with an external validation set for an API concentration range from 80 to 120 % of the targeted active content. The prediction error of 0.9 % (root mean standard error of prediction, RMSEP) was low, indicating the accuracy of the NIR method. The accuracy profile on the validation results, an innovative approach based on tolerance intervals, demonstrated the actual and future performance of the in-line NIR method. Accordingly, the present approach paves the way for real-time release-based quality system. [less ▲]

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See detailLes cultes isiaques à Emporion
Puccio, Laetizia ULg

in Pallas : Revue d'Etudes Antiques (2010), 84

This article presents a new interpretation of the temple M's content placed in the so-called sanctuary of Asklepios in Emporion. The sculptures are related to an inscription of the area and also to a ... [more ▼]

This article presents a new interpretation of the temple M's content placed in the so-called sanctuary of Asklepios in Emporion. The sculptures are related to an inscription of the area and also to a sigilado glass and chandeliers that come from the Roman city. All this proves the presence of an Egyptian worship in Emporion more complex than earlier. [less ▲]

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See detailIntérêt d'une prise en charge multidisciplinaire ambulatoire semi-intensive dans la lombalgie chronique
Demoulin, Christophe ULg; Grosdent, Stéphanie ULg; capron, Lucile et al

in Revue du Rhumatisme (2010), 77

Objectifs. – Cette étude souhaite apprécier l’efficacité d’un programme pluridisciplinaire ambulatoire semi-intensif, élaboré en fonction des exigences des organismes mutualistes belges et destiné aux ... [more ▼]

Objectifs. – Cette étude souhaite apprécier l’efficacité d’un programme pluridisciplinaire ambulatoire semi-intensif, élaboré en fonction des exigences des organismes mutualistes belges et destiné aux patients lombalgiques chroniques. Méthodes. – Parmi 262 patients souffrant de lombalgie chronique non spécifique inclus dans cette étude, 136 (73 femmes et 63hommes présentant des douleurs depuis 11,3 ans en moyenne) ont achevé un programme ambulatoire (36 séances de deux heures) comportant une éducation à l’économie rachidienne, une approche ergonomique et psychologique ainsi que des séances de reconditionnement physique. Trois séances (initiale [séance 1], intermédiaire (séance 18) et finale [séance 36]) évaluent les paramètres d’intensité de la douleur, d’incapacité fonctionnelle, de kinésiophobie, de connaissances cognitives et gestuelles ainsi que les performances physiques (force et endurance des muscles du tronc, mobilité du complexe lombo-pelvi-fémoral, endurance cardiorespiratoire). Résultats. – Tous les paramètres sont significativement améliorés lors de l’évaluation finale : diminution de l’intensité de la douleur (−44 %), des répercussions fonctionnelles (−40 %) et de la kinésiophobie (−11 %), amélioration des connaissances (+59 %) et de la gestuelle vertébrale (+95 %), augmentation de la force des muscles du tronc (+40 % en moyenne), de l’endurance des extenseurs du tronc (+90 %), de la mobilité (+8 %) et de l’endurance cardiorespiratoire (+18 %). Conclusions. – Une prise en charge pluridisciplinaire ambulatoire semi-intensive s’avère bénéfique pour les patients lombalgiques chroniques. Une adaptation des critères d’inclusion et une implication accrue du patient dans sa rééducation contribueraient à améliorer l’observance du programme. [less ▲]

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See detailMolecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation.
Yevenes, Gonzalo E; Moraga-Cid, Gustavo; Avila, Ariel et al

in Journal of Biological Chemistry (2010), 285(39), 30203-13

It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure. Thus, the differential ethanol ... [more ▼]

It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure. Thus, the differential ethanol sensitivity of diverse GlyR isoforms and mutants was explained by the presence of specific residues in putative alcohol pockets. Here, we demonstrate that ethanol sensitivity in two ligand-gated ion receptor members, the GlyR adult alpha(1) and embryonic alpha(2) subunits, can be modified through selective mutations that rescued or impaired Gbetagamma modulation. Even though both isoforms were able to physically interact with Gbetagamma, only the alpha(1) GlyR was functionally modulated by Gbetagamma and pharmacological ethanol concentrations. Remarkably, the simultaneous switching of two transmembrane and a single extracellular residue in alpha(2) GlyRs was enough to generate GlyRs modulated by Gbetagamma and low ethanol concentrations. Interestingly, although we found that these TM residues were different to those in the alcohol binding site, the extracellular residue was recently implicated in conformational changes important to generate a pre-open-activated state that precedes ion channel gating. Thus, these results support the idea that the differential ethanol sensitivity of these two GlyR isoforms rests on conformational changes in transmembrane and extracellular residues within the ion channel structure rather than in differences in alcohol binding pockets. Our results describe the molecular basis for the differential ethanol sensitivity of two ligand-gated ion receptor members based on selective Gbetagamma modulation and provide a new mechanistic framework for allosteric modulations of abuse drugs. [less ▲]

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See detailWorking memory load affects chronotype- and time-of-day dependent cerebral activity modulations
Schmidt, Christina ULg; Peigneux, Philippe ULg; Leclercq, Yves ULg et al

in Journal of Sleep Research (2010), 19(Suppl. 2),

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See detailStatistical inverse analysis based on genetic algorithm and principal component analysis: Applications to excavation problems and pressuremeter tests
Levasseur, Séverine ULg; Malécot, Yann; Boulon, Marc et al

in International Journal for Numerical and Analytical Methods in Geomechanics (2010), 34(5), 471-491

This study concerns the identification of constitutive models from geotechnical measurements by inverse analysis. Soil parameters are identified from measured horizontal displacements of sheet pile walls ... [more ▼]

This study concerns the identification of constitutive models from geotechnical measurements by inverse analysis. Soil parameters are identified from measured horizontal displacements of sheet pile walls and from a measured pressuremeter curve. An optimization method based on a genetic algorithm and a principal component analysis, developed and tested on synthetic data in a previous paper, is applied. These applications show that the conclusions deduced from synthetic problems can be extrapolated to real problems. The genetic algorithm is a robust optimization method which is able to deal with the non-uniqueness of the solution in identifying a set of solutions for a given uncertainty on the measurements. This set is then characterized by a principal component analysis (PCA) which gives a fi rst order approximation of the solution as an ellipsoid. When the solution set is not too curved in the research space, this ellipsoid characterizes the soil properties considering the measured data and the tolerate margins for the response of the numerical model. Besides, optimizations from di fferent measurements provide solution sets with a common area in the research space. This intersection gives a more relevant and accurate identification of parameters. Finally, we show that these identified parameters permit to reproduce geotechnical measurements not used in the identification process. [less ▲]

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See detailAgriculture et biodiversité
Hance, Thierri; Demeter, Sébatien; Le Roi, Alain et al

Book published by SPW DGARNE (2010)

Diversité des milieux et des paysages agricoles de Wallonie, réseau écologique.

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See detailCompte rendu de l'ouvrage de Augustin Güntzer, L'histoire de toute ma vie (trad. Monique Debus Kehr)
Donneau, Olivier ULg

in Revue d'Histoire Ecclésiastique (2010), 105(3-4), 885-888

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See detailA robust heuristic for the optimal selection of a portfolio of stocks
Schyns, Michael ULg

in International Journal of Operational Research (2010), 9(3), 258-271

This paper introduces a new optimization heuristic for the robustification of critical inputs under consideration in many problems. It is shown that it allows to improve significantly the quality and the ... [more ▼]

This paper introduces a new optimization heuristic for the robustification of critical inputs under consideration in many problems. It is shown that it allows to improve significantly the quality and the stability of the results for two classical financial problems, i.e. the Markowitz' portfolio selection problem and the computation of the financial beta. Focus here is on the robust Minimum Covariance Determinant (MCD) estimator which can easily be substituted to the classical estimators of location and scatter. By definition, the computation of this estimator gives rise to a combinatorial optimization problem. We present a new heuristic, called 'RelaxMCD', which is based on a relaxation of the problem to the continuous space. The utility of this approach and the performance of our heuristic, with respect to other competitors, are illustrated through extensive simulations. [less ▲]

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