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See detailLes points faibles du dispositif "assuétudes"
Vandoorne, Chantal ULg; Cherbonnier, Alain; Taeymans, Bernadette et al

in Cahiers de Prospective Jeunesse (2010), 56

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See detailFibromyalgia and related conditions: Electromyogram profile during isometric muscle contraction
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Dupont, Catherine ULg et al

in Joint Bone Spine (2010), 77

Objectives: To evaluate electromyogram (EMG) profiles in patients with three related conditions: fibromyalgia, chronic fatigue syndrome, and depression. Methods: We studied 44 healthy volunteers, 22 ... [more ▼]

Objectives: To evaluate electromyogram (EMG) profiles in patients with three related conditions: fibromyalgia, chronic fatigue syndrome, and depression. Methods: We studied 44 healthy volunteers, 22 patients with fibromyalgia, 11 patients with chronic fatigue syndrome, and 10 patients admitted for depression. The trapezius electromyogram was recorded during maximally sustained, bilateral, 90◦ abduction of the shoulders. EMG signal frequency and amplitude were measured throughout the test. Results: In the fibromyalgia group, isometric contraction duration was significantly shorter than in the other two patient groups (P < 0.001) and the EMG frequency and amplitude pattern indicated premature discontinuation of the muscle contraction. Findings in the chronic fatigue patients were similar to those in the healthy controls. The patients with depression had a distinctive EMG profile characterized by excessive initial motor-unit recruitment with a shift in the frequency spectrum. Conclusions: Fibromyalgia was associated with a specific EMG pattern indicating premature discontinuation of the muscle contraction. Therefore, maximal voluntary muscle contraction tests may be of limited value for assessing function in fibromyalgia patients. Chronic fatigue syndrome patients had similar EMG findings to those in the healthy controls. The EMG alterations in the patients with depression were consistent with manifestations of psychomotor retardation. [less ▲]

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See detailDiabète, convention et trajet de soins
RADERMECKER, Régis ULg

in Actualités Innovations Médecine (2010), (12), 21-22

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See detailSustained efficacy of occipital nerve stimulation in drug-resistant chronic cluster headache after up to 5 years treatment
Magis, Delphine ULg; Gérardy, Pierre-Yves; Remacle, Jean-Michel et al

in Journal of Headache & Pain (2010), 11(Suppl 1), 15

Background. Drug-resistant chronic cluster headache (drCCH) is a devastating condition for which various invasive procedures have been tempted without any satisfactory effect. Our prospective pilot study ... [more ▼]

Background. Drug-resistant chronic cluster headache (drCCH) is a devastating condition for which various invasive procedures have been tempted without any satisfactory effect. Our prospective pilot study of great occipital nerve stimulation (ONS) in 8 drCCH patients showed encouraging results at 15 months (1). Methods. We recruited 15 patients with drCCH according to the previously published criteria of intractability (2). They were implanted with suboccipital stimulators on the side of their headache. Long-term follow-up was achieved by questionnaires administered during a headache consultation and/or by telephone interviews. Results. One patient had an immediate post operative infection of the material. Mean time with ONS was 28.8 months (range 3-60 months). Nine of the 14 remaining patients were totally pain-free (64%), 2 patients had an improvement in frequency exceeding 90% and one patient a 89% amelioration. Two patients did not respond or described mild improvement. Intensity of residual attacks was not improved by ONS. Four patients (29%) were able to reduce their prophylaxis. Common technical problems were battery depletion (N=8/14, 57%) and material infection (N=3/15, 20%). Recurrent battery replacement (until 2/ year in one patient) is now avoided by the availability of rechargeable batteries. Clinical peculiarities associated with ONS were occurrence of infrequent contralateral attacks (N=5/14, 36%), and/or isolated ispilateral autonomic attacks (N=5/14, 36%). Rapid attack recurrence after stimulator switch off was reported by 7/12 improved patients (58%). Two patients found ONS-related paresthesias unbearable; one had his stimulator removed, the other switched it off though he was objectively ameliorated. Subjectively, nine patients are very satisfied by ONS and one patient moderately satisfied. Conclusions. Our long-term follow-up confirms the efficacy of ONS in drCCH, which remains a safe and well-tolerated technique. The occurrence of contralateral attacks and isolated autonomic attacks in nearly 50% of ONS responders may have therapeutic and pathophysiological implications. [less ▲]

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See detailStructure and properties of a complex of alpha-synuclein and a single-domain camelid antibody.
De Genst, Erwin J; Guilliams, Tim; Wellens, Joke et al

in Journal of Molecular Biology (2010), 402(2), 326-43

The aggregation of the intrinsically disordered protein alpha-synuclein to form fibrillar amyloid structures is intimately associated with a variety of neurological disorders, most notably Parkinson's ... [more ▼]

The aggregation of the intrinsically disordered protein alpha-synuclein to form fibrillar amyloid structures is intimately associated with a variety of neurological disorders, most notably Parkinson's disease. The molecular mechanism of alpha-synuclein aggregation and toxicity is not yet understood in any detail, not least because of the paucity of structural probes through which to study the behavior of such a disordered system. Here, we describe an investigation involving a single-domain camelid antibody, NbSyn2, selected by phage display techniques to bind to alpha-synuclein, including the exploration of its effects on the in vitro aggregation of the protein under a variety of conditions. We show using isothermal calorimetric methods that NbSyn2 binds specifically to monomeric alpha-synuclein with nanomolar affinity and by means of NMR spectroscopy that it interacts with the four C-terminal residues of the protein. This latter finding is confirmed by the determination of a crystal structure of NbSyn2 bound to a peptide encompassing the nine C-terminal residues of alpha-synuclein. The NbSyn2:alpha-synuclein interaction is mediated mainly by side-chain interactions while water molecules cross-link the main-chain atoms of alpha-synuclein to atoms of NbSyn2, a feature we believe could be important in intrinsically disordered protein interactions more generally. The aggregation behavior of alpha-synuclein at physiological pH, including the morphology of the resulting fibrillar structures, is remarkably unaffected by the presence of NbSyn2 and indeed we show that NbSyn2 binds strongly to the aggregated as well as to the soluble forms of alpha-synuclein. These results give strong support to the conjecture that the C-terminal region of the protein is not directly involved in the mechanism of aggregation and suggest that binding of NbSyn2 could be a useful probe for the identification of alpha-synuclein aggregation in vitro and possibly in vivo. [less ▲]

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See detailAxion-like particles and circular polarisation of active galactic nuclei
Payez, Alexandre ULg; Cudell, Jean-René ULg; Hutsemekers, Damien ULg

in Jaeckel, Joerg; Lindner, Axel; Redondo, Javier (Eds.) Proceedings of the 5th Patras Workshop on Axions, WIMPs and WISPs PATRAS 2009 (2010)

The measurements of the linear polarisation of visible light from quasars give strong evidence for large-scale coherent orientations of their polarisation vectors in some regions of the sky. We show that ... [more ▼]

The measurements of the linear polarisation of visible light from quasars give strong evidence for large-scale coherent orientations of their polarisation vectors in some regions of the sky. We show that these observations can be explained by the mixing of the photons with very light pseudoscalar (axion-like) particles in extragalactic magnetic fields during their propagation. We present a new treatment in terms of wave packets and discuss the circular polarisation. [less ▲]

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See detailReduced organ failure with effective glycemic control
PREISER, Jean-Charles ULg; Chase, J. G.; Pretty, C. G. et al

in Intensive Care Medicine (2010), 36(2), 173-173

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See detailOn Vershikian and I-cosy random variables and filtrations
Laurent, Stéphane ULg

in Teoriya Veroyatnostei i ee Primeneniya (2010), 55

We prove that the equivalence between Vershik’s standardness criterion and the I-cosiness criterion for a filtration in discrete, negative time, holds separately for each random variable. This gives a ... [more ▼]

We prove that the equivalence between Vershik’s standardness criterion and the I-cosiness criterion for a filtration in discrete, negative time, holds separately for each random variable. This gives a strengthening and a more direct proof of the global equivalence between these two criteria. We also provide more elementary original propositions on Vershik’s standardness criterion, while emphasizing that similar statements for I-cosiness are sometimes not so obvious. [less ▲]

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See detailNéerlandais / Presse radio
Yans, Baudoin ULg; Engelen, Nicole ULg; Nachtergaele, Lutgarde

Book published by De Boeck Université (2010)

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See detailThe effectiveness of inpatient geriatric evaluation and management units: a systematic review and meta-analysis.
Van Craen, Katleen; Braes, Tom; Wellens, Nathalie et al

in Journal of the American Geriatrics Society (2010), 58(1), 83-92

OBJECTIVES: To examine how geriatric evaluation and management units (GEMUs) are organized and to examine the effectiveness of admission on a GEMU. DESIGN: Systematic review and meta-analysis based on ... [more ▼]

OBJECTIVES: To examine how geriatric evaluation and management units (GEMUs) are organized and to examine the effectiveness of admission on a GEMU. DESIGN: Systematic review and meta-analysis based on literature search of multiple databases and the references lists of all identified articles and by contacting authors. SETTING: GEMUs. PARTICIPANTS: Elderly people admitted to a GEMU. MEASUREMENTS: Quality of the studies was assessed on 10 criteria. The outcome parameters were mortality, institutionalization, functional decline, readmission, and length of stay at different follow-up points. A random-effects meta-analysis was performed using Hedges' gu and variance of relative risk (RR). RESULTS: GEMUs are organized in a heterogeneous way and the included studies gave no thorough description of comprehensive geriatric assessment (CGA). Involvement of a multidisciplinary team was a key element in all GEMUs. The individual trials showed that admission to a GEMU has one or more favorable effects on the outcomes of interest, with two significant effects in the meta-analysis: less functional decline at discharge from the GEMU (RR=0.87, 95% confidence interval (CI)=0.77-0.99; P=.04) and a lower rate of institutionalization 1 year after discharge (RR=0.78, CI=0.66-0.92; P=.003). For the other outcomes in the meta-analysis, a GEMU did not induce significantly different outcomes than usual care. CONCLUSION: This meta-analysis shows a significant effect in favor of the GEMU group on functional decline at discharge and on institutionalization after 1 year. There is heterogeneity between the studies, poor quality of some randomized controlled trials, and shortage of information about CGA. Multidisciplinary CGA offered in a GEMU may add value to the care for frail older persons admitted to the hospital, but the limitations confirm the need for well-designed studies using explicit CGA and more-structured and -coherent assessment instruments such as the Minimum Data Set Resident Assessment Instrument. [less ▲]

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See detailChimie (3e partie)
Heinrichs, Benoît ULg

Learning material (2010)

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See detailMathémagie et au-delà
Rigo, Michel ULg

Learning material (2010)

Nous présentons ici 5 tours de magie ne nécessitant aucune habileté particulière de la part de l'apprenti magicien : des tours de cartes, des tours de divination et le célèbre tour du ``barman aveugle ... [more ▼]

Nous présentons ici 5 tours de magie ne nécessitant aucune habileté particulière de la part de l'apprenti magicien : des tours de cartes, des tours de divination et le célèbre tour du ``barman aveugle avec des gants de boxe''. Contrairement au magicien qui ne dévoile jamais ses secrets, ici, nous expliquons que ces tours reposent sur diverses propriétés et constructions mathématiques. Ces dernières débouchent sur de véritables questions de recherche actuelle en théorie des graphes ou en combinatoire des mots et même sur de possibles applications en robotique et automatisation ! Il y en aura donc pour tous les goûts... et tous les niveaux (suivant l'auditoire, l'exposé sera adapté au niveau des élèves de la 4ième à la 6ième secondaire, voire même aux étudiants universitaires). Ce texte présente donc un matériel qui dépassera souvent (et de loin) le ``spectacle''. [less ▲]

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See detailNonrenal disease activity following mycophenolate mofetil or intravenous cyclophosphamide as induction treatment for lupus nephritis: findings in a multicenter, prospective, randomized, open-label, parallel-group clinical trial
Ginzler, Ellen M; Wofsy, David; Isenberg, David et al

in Arthritis and Rheumatism (2010), 62(1), 211-221

OBJECTIVE: To assess the effect of mycophenolate mofetil compared with intravenous pulses of cyclophosphamide on the nonrenal manifestations of lupus nephritis. METHODS: Patients with active lupus ... [more ▼]

OBJECTIVE: To assess the effect of mycophenolate mofetil compared with intravenous pulses of cyclophosphamide on the nonrenal manifestations of lupus nephritis. METHODS: Patients with active lupus nephritis (renal biopsy class III, IV, or V) were recruited for the study (n = 370) and treated with mycophenolate mofetil (target dosage 3 gm/day) or intravenous cyclophosphamide (0.5-1.0 gm/m(2)/month), plus tapered prednisone, for 24 weeks. Nonrenal outcomes were determined using measures of whole body disease activity, including the British Isles Lupus Assessment Group (BILAG) disease activity index, the Safety of Estrogens in Lupus Erythematosus: National Assessment (SELENA) version of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and immunologic variables. RESULTS: Both treatments were effective on whole body disease activity in the systems examined, as indicated by changes in the classic BILAG index. With either treatment, remission was induced, notably in the mucocutaneous, musculoskeletal, cardiovascular/respiratory, and vasculitis systems, and flares were rare, as measured by the SELENA-SLEDAI. Levels of complement C3, C4, and CH50 and titers of anti-double-stranded DNA antibodies were normalized after treatment with either mycophenolate mofetil or intravenous cyclophosphamide. CONCLUSION: In addition to the efficacy of both treatments on the renal system, this analysis showed that remission could also be induced in other systems. There was no clear difference in efficacy between mycophenolate mofetil and intravenous cyclophosphamide in ameliorating either the renal or nonrenal manifestations. Mycophenolate mofetil is, therefore, a suitable alternative to cyclophosphamide for the treatment of renal and nonrenal disease manifestations in patients with biopsy-proven lupus nephritis. [less ▲]

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See detailQuand les tangentes étaient touchantes
Bair, Jacques ULg; Henry, Valérie ULg

in Tangente Sup (2010), 54

Exposé moderne d'un algorithme, initialement trouvé par le belge Sluse (1622-1685), pour déterminer la tangente à une courbe plane.

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See detailHematopoietic stem cell transplantation in the treatment strategy of acute leukemia
Baron, Frédéric ULg; Beguin, Yves ULg

in Belgian Journal of Medical Oncology [=BJMO] (2010), 4

This review article discusses the current indications for allogeneic hematopoietic stem cell transplantation in adult patients with acute myeloid or lymphoblastic leukemia

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See detailEn las montañas de la locura
Lovecraft, Howard Phillips; Willson, Patricia ULg

Book published by Libros del Zorro Rojo (2010)

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See detailMise au point de l’indice composition dans le cadre de l’indicateur phytoplancton - les indices de composition phytoplanctonique en eaux côtières : synthèse bibliographique
Goffart, Anne ULg

Report (2010)

Ce rapport rappelle brièvement pourquoi le phytoplancton est un excellent indicateur de l’état des eaux côtières et synthétise les limites adaptatives des communautés phytoplanctoniques en réponse aux ... [more ▼]

Ce rapport rappelle brièvement pourquoi le phytoplancton est un excellent indicateur de l’état des eaux côtières et synthétise les limites adaptatives des communautés phytoplanctoniques en réponse aux perturbations d’origine anthropique (essentiellement l’enrichissement en sels nutritifs). Il présente ensuite l’indicateur phytoplanctonique idéal et résume l’état des connaissances en matière d’indices de composition et d’indicateurs phytoplanctoniques intégrant la composition. Les méthodes de calcul des indices sont expliquées lorsque les informations disponibles sont suffisamment claires et détaillées. Le rapport se termine par la proposition de pistes à explorer pour la mise au point et la validation d’un indice de composition phytoplanctonique qui soit opérationnel et représentatif de la composition taxonomique d’une masse d’eau côtière et de son évolution temporelle. [less ▲]

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