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See detailDummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning
Musat, E.; Roelofs, E.; Bar-Deroma, R. et al

in Radiotherapy & Oncology (2010), 95(2), 218-224

Purpose: Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas. Materials and methods: RT plans provided for dummy cases ... [more ▼]

Purpose: Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas. Materials and methods: RT plans provided for dummy cases were evaluated and compared against expert plans. We analysed: (1) tumour and organs-at-risk delineation, (2) geometric and dosimetric characteristics, (3) planning parameters, compliance with dose prescription and Dmax for OAR (4) indices: RTOG conformity index (CI), coverage factor (CF), tissue protection factor (PF); conformity number (CN = PF× CF); dose homogeneity in PTV (U). Results: Forty-one RT plans were evaluated. Only two (5%) centres were requested to repeat CTV-PTV delineations. Three (7%) plans had a significant under-dosage and dose homogeneity in one deviated > 10%. Dose distribution was good with mean values of 1.5, 1, 0.68, and 0.68 (ideal values = 1) for CI, CF, PF, and CN, respectively. CI and CN strongly correlated with PF and they correlated with PTV. Planning with more beams seems to increase PTV Dmin, improving CF. U correlated with PTV Dmax. Conclusion: Preliminary results of the dummy run procedure indicate that most centres conformed to protocol requirements. To quantify plan quality we recommend systematic calculation of U and either CI or CN, both of which measure the amount of irradiated normal brain tissue. © 2010 Elsevier Ireland Ltd. All rights reserved. [less ▲]

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See detailMathematical modelling of cell aggregates for bone tissue engineering using continuum methods
Geris, Liesbet ULg; Clarke, T.; Ashbourn, J.

in Middleton, J.; Jacobs, C.; Walker, B. (Eds.) et al 9th International symposium on Computer Methods in Biomechanics and Biomedical Engineering (2010)

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See detailMaqriziana XI. Al-Maqrīzī et al-Ṣafadī: analyse de la (re)construction d'un récit biographique
Bauden, Frédéric ULg

in Quaderni di Studi Arabi (2010), 4(2009), 99-136

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See detailThe effectiveness of inpatient geriatric evaluation and management units: a systematic review and meta-analysis.
Van Craen, Katleen; Braes, Tom; Wellens, Nathalie et al

in Journal of the American Geriatrics Society (2010), 58(1), 83-92

OBJECTIVES: To examine how geriatric evaluation and management units (GEMUs) are organized and to examine the effectiveness of admission on a GEMU. DESIGN: Systematic review and meta-analysis based on ... [more ▼]

OBJECTIVES: To examine how geriatric evaluation and management units (GEMUs) are organized and to examine the effectiveness of admission on a GEMU. DESIGN: Systematic review and meta-analysis based on literature search of multiple databases and the references lists of all identified articles and by contacting authors. SETTING: GEMUs. PARTICIPANTS: Elderly people admitted to a GEMU. MEASUREMENTS: Quality of the studies was assessed on 10 criteria. The outcome parameters were mortality, institutionalization, functional decline, readmission, and length of stay at different follow-up points. A random-effects meta-analysis was performed using Hedges' gu and variance of relative risk (RR). RESULTS: GEMUs are organized in a heterogeneous way and the included studies gave no thorough description of comprehensive geriatric assessment (CGA). Involvement of a multidisciplinary team was a key element in all GEMUs. The individual trials showed that admission to a GEMU has one or more favorable effects on the outcomes of interest, with two significant effects in the meta-analysis: less functional decline at discharge from the GEMU (RR=0.87, 95% confidence interval (CI)=0.77-0.99; P=.04) and a lower rate of institutionalization 1 year after discharge (RR=0.78, CI=0.66-0.92; P=.003). For the other outcomes in the meta-analysis, a GEMU did not induce significantly different outcomes than usual care. CONCLUSION: This meta-analysis shows a significant effect in favor of the GEMU group on functional decline at discharge and on institutionalization after 1 year. There is heterogeneity between the studies, poor quality of some randomized controlled trials, and shortage of information about CGA. Multidisciplinary CGA offered in a GEMU may add value to the care for frail older persons admitted to the hospital, but the limitations confirm the need for well-designed studies using explicit CGA and more-structured and -coherent assessment instruments such as the Minimum Data Set Resident Assessment Instrument. [less ▲]

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See detailQuantum Spin Transport in Carbon Chains
Zanolli, Zeila ULg; Onida, Giovanni; Charlier, Jean-Christophe

in ACS Nano (2010), 4(9), 5174-5180

First-principles and non-equilibrium Green’s function approaches are used to predict spin-polarized electronic transport in monatomic carbon chains covalently connected to graphene nanoribbons, as ... [more ▼]

First-principles and non-equilibrium Green’s function approaches are used to predict spin-polarized electronic transport in monatomic carbon chains covalently connected to graphene nanoribbons, as recently synthetized experimentally (Jin, C.; et al. Phys. Rev. Lett. 2009, 102, 205501−205504). Quantum electron conductances exhibit narrow resonant states resulting from the simultaneous presence of open conductance channels in the contact region and on the chain atoms. Odd-numbered chains, which acquire metallic or semiconducting character depending on the nature of the edge at the graphene contact, always display a net spin polarization. The combination of electrical and magnetic properties of chains and contacts results in nanodevices with intriguing spintronic properties such as the coexistence of magnetic and semiconducting behaviors. [less ▲]

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See detailMathémagie et au-delà
Rigo, Michel ULg

Learning material (2010)

Nous présentons ici 5 tours de magie ne nécessitant aucune habileté particulière de la part de l'apprenti magicien : des tours de cartes, des tours de divination et le célèbre tour du ``barman aveugle ... [more ▼]

Nous présentons ici 5 tours de magie ne nécessitant aucune habileté particulière de la part de l'apprenti magicien : des tours de cartes, des tours de divination et le célèbre tour du ``barman aveugle avec des gants de boxe''. Contrairement au magicien qui ne dévoile jamais ses secrets, ici, nous expliquons que ces tours reposent sur diverses propriétés et constructions mathématiques. Ces dernières débouchent sur de véritables questions de recherche actuelle en théorie des graphes ou en combinatoire des mots et même sur de possibles applications en robotique et automatisation ! Il y en aura donc pour tous les goûts... et tous les niveaux (suivant l'auditoire, l'exposé sera adapté au niveau des élèves de la 4ième à la 6ième secondaire, voire même aux étudiants universitaires). Ce texte présente donc un matériel qui dépassera souvent (et de loin) le ``spectacle''. [less ▲]

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See detailThe 900-yr sedimentary record of Lago Thompson, Northern Chilean Patagonia
Fagel, Nathalie ULg; Nuttin, L.; Bertrand, S. et al

Poster (2010)

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See detailHeadache: spreading from molecules to patients
Schoenen, Jean ULg; Coppola, G.

in Lancet Neurology (2010), 9

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See detail"Fitness" versus "fatness": impacts cardio-metaboliques respectifs aux differents ages de la vie.
Esser, N.; Paquot, Nicolas ULg; Scheen, André ULg

in Revue Médicale de Liège (2010), 65(4), 199-205

Almost 35% of overweight or obese individuals are free of any metabolic disorder. This may be explained by a favourable fat distribution. However, those individuals also have a higher level of physical ... [more ▼]

Almost 35% of overweight or obese individuals are free of any metabolic disorder. This may be explained by a favourable fat distribution. However, those individuals also have a higher level of physical fitness. Therefore, deleterious cardiometabolic effects of excessive fat mass ("fatness") might be counterbalanced by regular physical activity leading to high cardiorespiratory fitness ("fitness"). The present article first analyzes the various pathophysiological mechanisms explaining why muscular exercise has beneficial effects and second, describes the relationship between "fitness" and "fatness" and their respective cardiometabolic consequences at various ages: adolescents, adults and elderly people. [less ▲]

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See detailStrategies pour eviter l'inertie et la non-observance dans les essais cliniques.
Jandrain, Bernard ULg; Ernest, Philippe ULg; Radermecker, Régis ULg et al

in Revue Médicale de Liège (2010), 65(5-6), 246-9

Randomised controlled trials play a key role in evidence-based medicine as far as the assessment of both efficacy and safety of drugs is concerned. Various strategies are used to avoid physician's inertia ... [more ▼]

Randomised controlled trials play a key role in evidence-based medicine as far as the assessment of both efficacy and safety of drugs is concerned. Various strategies are used to avoid physician's inertia and to combat patient's non compliance, two pitfalls that may hinder the demonstration of the therapeutic efficacy of the drug. Clinical inertia may be limited by titration, forced or optional, driven by therapeutic targets, or by the use, if necessary, of rescue medications. Compliance may be verified by "pill count". This simple technique allows to exclude non compliant patients when they are detected during the placebo run-in period before randomisation or not to take into account patients with poor compliance in the final evaluation by using a statistical analysis restricted to individuals who have strictly adhered to the study protocol ("per protocol analysis"). Self-monitoring and patient's empowerment in the treatment also contribute to improve drug compliance. Clinicians may take advantage of these approaches derived from clinical trials to improve their daily practice. [less ▲]

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See detailFlow of magnetized grains in a rotating drum
Lumay, Geoffroy ULg; Vandewalle, Nicolas ULg

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2010)

We have experimentally investigated the influence of a magnetic interaction between the grains on the flow of a granular material in a rotating drum.

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See detailNew Method to Combine Pedigree and Molecular Relationships applied to Brandrood Cattle
Bömcke, Elisabeth ULg; Windig, J. J.; Gengler, Nicolas ULg

in 9th World Congress of Genetics Applied to Livestock Production: Leipzig, Germany (2010)

Relationship coefficients are traditionally based on pedigree data. Today, they are often replaced by coefficients calculated from molecular data, for example, microsatellites-based relationships for bio ... [more ▼]

Relationship coefficients are traditionally based on pedigree data. Today, they are often replaced by coefficients calculated from molecular data, for example, microsatellites-based relationships for bio-diversity studies or genomic relationships for prediction of breeding values. However, in many situations, optimal combination of both sources would be the best solutions; i.e. when population is incompletely genotyped or when pedigree information is sparse. Also even dense markers do not reflect the whole genome. The objective of this study was to applied a new method to calculate a relationship matrix by the combination of molecular and pedigree data on Brandrood cattle. The results showed that combining marker and pedigree information produced more accurate A-matrices what will be useful for future management of the breed genetic variability. [less ▲]

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See detailRecognition and validation of non-formal and informal learning in French-speaking Belgium. Discourse and practices
Peters, Stéphanie ULg; Mahieu, Céline; Salmon, Arnaud et al

in Lifelong Learning in Europe (2010), 15(2), 119-128

The validation of formal and informal learning has been practiced in French-speaking Belgium for several years, via the mechanisms known as Recognition of Non-Formal and Informal Learning (RNF-IFL) and ... [more ▼]

The validation of formal and informal learning has been practiced in French-speaking Belgium for several years, via the mechanisms known as Recognition of Non-Formal and Informal Learning (RNF-IFL) and Accreditation of Prior Experiential Learning (APEL). These credits contribute in the fullest way possible to the political project for the development of society based on knowledge and lifelong learning. Actors involved in the validation process must deal with a more and more fragmented knowledge. Further, the abovementioned mechanisms of validation are related to many questions, involving identity, methodology, and strategic and sociopolitical matters, all of which are touched upon in the present article. [less ▲]

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See detailDroplets sliding on fibres
Gilet, Tristan ULg; Terwagne, Denis ULg; Vandewalle, Nicolas ULg

in European Physical Journal E -- Soft Matter (2010), 31(3), 253

We present the results of a combined experimental and theoretical investigation of oil droplets sliding on fibres. First, both the axisymmetric shape and the motion of a droplet on a vertical fibre are ... [more ▼]

We present the results of a combined experimental and theoretical investigation of oil droplets sliding on fibres. First, both the axisymmetric shape and the motion of a droplet on a vertical fibre are described. The motion is shown to result from a balance between the droplet weight and the viscous stresses. On a long-term range, the droplet loses some mass through coating the fibre, which decreases its velocity. In a second time, we rationalize the behaviour of a droplet that encounters a junction between vertical and horizontal fibres. Depending on its size, the droplet may cross the junction or remain blocked. The transition is well described by an ordinary differential equation equivalent to a damped harmonic oscillator truncated to the neighbourhood of the horizontal fibre. This simple system is the basic element for more complex fiber networks that would be useful in microfluidic applications involving droplets. [less ▲]

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See detailMieux traiter le diabète : combattre l’inertie et améliorer l’adhésion au traitement.
SCHEEN, André ULg; PHILIPS, Jean-Christophe ULg; PAQUOT, Nicolas ULg

in Association belge du diabète (2010), 53

Le diabète est une maladie chronique par excellence. Comme beaucoup d’autres maladies chroniques, le diabète, qu’il soit de type 1 ou plus encore de type 2, est d’origine complexe, combinant l’infl uence ... [more ▼]

Le diabète est une maladie chronique par excellence. Comme beaucoup d’autres maladies chroniques, le diabète, qu’il soit de type 1 ou plus encore de type 2, est d’origine complexe, combinant l’infl uence de facteurs génétiques et environnementaux. Le but du traitement est de corriger au mieux l’hyperglycémie chronique, mais aussi d’autres facteurs de risque (hypertension artérielle, hypercholestérolémie,…), de façon à prévenir la survenue de complications, garantir une bonne qualité de vie et améliorer l’espérance de vie. [less ▲]

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