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See detailCritical analysis of several analytical method validation strategies in the framework of the fit for purpose concept.
Rozet, Eric ULg; Bouabidi, A.; Fillet, Marianne ULg et al

in Journal of Chromatography. A (2010), 1217

Analytical method validation is a mandatory step at the end of the development in all analytical laboratories. It is a highly regulated step of the life cycle of a quantitative analytical method. However ... [more ▼]

Analytical method validation is a mandatory step at the end of the development in all analytical laboratories. It is a highly regulated step of the life cycle of a quantitative analytical method. However, even if some documents have been published there is a lack of clear guidance for the methodology to follow to adequately decide when a method can be considered as valid. This situation has led to the availability of several methodological approaches and it is therefore the responsibility of the analyst to choose the best one. The classical decision processes encountered during method validation evaluation are compared, namely the descriptive, difference and equivalence approaches. Furthermore a validation approach using accuracy profile computed by means of beta-expectation tolerance interval and total measurement error is also available. In the present paper all of these different validation approaches were applied to the validation of two analytical methods. The evaluation of the producer and consumer risks by Monte Carlo simulations were also made in order to compare the appropriateness of these various approaches. The classical methodologies give rise to inadequate and contradictory conclusions which do not allow them to answer adequately the objective of method validation, i.e. to give enough guarantees that each of the future results that will be generated by the method during routine use will be close enough to the true value. It is found that the validation methodology which gives the most guarantees with regards to the reliability or adequacy of the decision to consider a method as valid is the one based on the use of the accuracy profile. [less ▲]

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See detailFormulation des bétons
Courard, Luc ULg

Learning material (2010)

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See detailThe impact of concomitant rhinitis on asthma-related quality of life and asthma control.
Vandenplas, O.; Dramaix, M.; Joos, G. et al

in Allergy (2010)

To cite this article: Vandenplas O, Dramaix M, Joos G, Louis R, Michils A, Verleden G, Vincken W, Vints A-M, Herbots E, Bachert C. The impact of concomitant rhinitis on asthma-related quality of life and ... [more ▼]

To cite this article: Vandenplas O, Dramaix M, Joos G, Louis R, Michils A, Verleden G, Vincken W, Vints A-M, Herbots E, Bachert C. The impact of concomitant rhinitis on asthma-related quality of life and asthma control. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02365.x. Abstract Background: Characterizing the interactions between the upper and lower airways is important for the management of asthma. This study aimed at assessing the specific impact of concomitant rhinitis on asthma-related quality of life (QOL) and asthma control. Methods: A cross-sectional, observational survey was conducted among 1173 patients with asthma (aged 12-45) recruited by general practitioners and chest physicians. AR was defined by self-reported rhinitis symptoms and previously documented sensitization to inhalant allergens. The primary outcomes were (1) asthma control assessed by the Asthma Control Questionnaire (ACQ) and (2) asthma-specific QOL evaluated through the Mini Asthma Quality of Life Questionnaire (mAQLQ). Results: AR was present in 73.9% of the population with asthma and nonallergic rhinitis (NAR) in 13.6%. AR and NAR were associated with an increased risk of uncontrolled asthma (i.e. ACQ score > 1.5) with adjusted odds ratios (OR) of 2.00 (95% confidence interval [CI]: 1.35-2.97) and 1.77 (95%CI: 1.09-2.89), respectively. Multivariate linear regression analysis showed that AR and NAR had a modest, although significant, negative impact on the global mAQLQ score (beta coefficient: -0.293, standard error [SE]: 0.063 and beta coefficient: -0.221, SE: 0.080, P < 0.001, respectively), even after adjustment for the level of asthma control and demographic characteristics. Conclusion: This survey provides direct evidence that AR and NAR are associated with an incremental adverse impact on the disease-specific QOL of patients with asthma and the level of asthma control. Further investigations are required to determine whether appropriate treatment of rhinitis would efficiently reduce asthma morbidity. [less ▲]

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See detailHematopoietic stem cell transplantation in the treatment strategy of acute leukemia
Baron, Frédéric ULg; Beguin, Yves ULg

in Belgian Journal of Medical Oncology [=BJMO] (2010), 4

This review article discusses the current indications for allogeneic hematopoietic stem cell transplantation in adult patients with acute myeloid or lymphoblastic leukemia

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See detailVersican overexpression in human breast cancer lesions: Known and new isoforms for stromal tumor targeting.
Kischel, Philippe ULg; Waltregny, David ULg; Dumont, Bruno ULg et al

in International Journal of Cancer = Journal International du Cancer (2010), 126(3), 640-50

Proteoglycans play a key role in cancer development and progression by participating in the constitution of a specific fertile tumor microenvironment. As they are largely overexpressed in the malignant ... [more ▼]

Proteoglycans play a key role in cancer development and progression by participating in the constitution of a specific fertile tumor microenvironment. As they are largely overexpressed in the malignant stroma, proteoglycans provide a reservoir of potential new targets for anticancer therapies, because they can serve to convey toxic payloads in the close proximity of cancer cells and subsequently destroy them. In this context, versican, a proteoglycan largely overexpressed in several solid cancers, bears the potential to be such an ideal target. As 4 main versican isoforms have been characterized, we sought to determine which isoform could represent the best target in human breast cancer. We used a series of 10 primary breast cancer lesions that were characterized as overexpressing the versican protein, when compared with matched normal breast tissues, using shotgun mass spectrometry and immunohistochemistry experiments. Quantitative polymerase chain reaction and western-blotting experiments were used to evaluate versican isoform expression in breast cancer/normal tissue pairs for which ARN quality was excellent. All known isoforms were significantly overexpressed in the malignant lesions, both at the mRNA and at the protein levels. In the course of this study, we also identified and cloned a new alternatively spliced versican isoform, referred to as V4, which was also found to be upregulated in human breast cancer. This study provides for the first time a comprehensive mRNA and protein analysis of versican isoforms expression in human breast tissues, and offers insights into which therapeutic strategy would be best suited to target versican in human breast cancer lesions. [less ▲]

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See detailDéveloppement d’un modèle stoechiométrique de la sulfato-réduction par des bactéries sulfato-réductrices en lagunage anaérobie
Harerimana, Casimir ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2010), 14(S2), 577-582

One of the most known disadvantages of the technique of lagoon is the generation of smells, often associated with the presence of hydrogen sulfide (H2S), itself generated by the process of sulfate ... [more ▼]

One of the most known disadvantages of the technique of lagoon is the generation of smells, often associated with the presence of hydrogen sulfide (H2S), itself generated by the process of sulfate-reduction. In this paper, we have built a stoichiometric model of sulfate-reduction by providing balanced equations against the elements, electrons, charge and energy. In our model, sulfate acts as an electron acceptor and organic compounds such as lactate, propionate, butyrate, ethanol and acetate are in turn sources of carbon and electron donors. This model allows to quantify the production of sulfide and predicts the variation of alkalinity during the process of sulfate-reduction. [less ▲]

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See detail"Renonciation à succession" (commentaire de l'article 1185 du Code judiciaire)
Moreau, Pierre ULg

in Les procédures particulières et le droit judiciaire familial, P. Moreau (coord.), in La jurisprudence du Code judiciaire commentée, vol. III, G. de Leval (dir.) (2010)

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See detailLe droit européen de la concurrence au banc des accusés
Petit, Nicolas ULg

in Revue de la Faculté de Droit de l'Université de Liège (2010), (2),

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See detailA new case of consensual decision: collective movement in earthworms
Zirbes, Lara ULg; Deneubourg, Jean-Louis; Brostaux, Yves ULg et al

in Ethology (2010), 115

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See detailNiveau de contamination et spéciation des métaux lourds dans l'Oued Fès et l'Oued Sebou.
Bouezmarni, Mohamed ULg; Debbaut, Vincent ULg; Diouri, S. El Edrissi et al

Conference (2010)

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See detailMeasuring the importance of competition: a new formulation of the problem
Damgaard, Christian; Fayolle, Adeline ULg

in Journal of Ecology (2010), (98), 1-6

1. Currently, there is a debate among plant ecologists on the concepts of the intensity of competition and the importance of competition, which is central to many issues of modern plant population ecology ... [more ▼]

1. Currently, there is a debate among plant ecologists on the concepts of the intensity of competition and the importance of competition, which is central to many issues of modern plant population ecology and plant community ecology. 2. It is problematic that the current measures of intensity and importance of competition, typically, are reported as dimensionless indices because they hide the fact that both indices are functions of plant density and the level of the environmental gradient. 3. Here, a new formulation of the concepts is suggested, which explicitly highlights the functional dependencies on plant density and the level of the environmental gradient. The new measures are a generalization of the previous indices and correspond to the previous indices in the case of a simple experimental design. 4. The suggested measures of the intensity and importance of competition are exemplified using data from a response surface competition experiment between Agrostis capillaris and Festuca ovina along a herbicide gradient, where the expected clear effect of plant density was demonstrated. 5. Synthesis. As the suggested measures of the intensity and importance of competition explicitly highlight the functional dependencies on plant density and the level of the environmental gradient, we think that they will help to ensure a closer connection between experimental plant ecology and the attempts to model plant populations and communities. [less ▲]

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See detailBelgian IPY Symposium 'The contribution of Belgian research to the achievements of the International Polar Year 2007-9
Dehairs, Frank; Decleir, Hugo; De Broyer, Claude et al

Book published by Universa Press (2010)

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See detailComparison of accuracy of sonography, rectal palpation, and pregnancy-associated glycoproteins tests for pregnancy diagnosis in cows
Gajewski, Z.; Petrajtis, M.; Melo de Sousa, Noelita ULg et al

in Proceedings of the XIth Middle European Buiatrics Congress (2010)

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See detailMathematical modelling of cell aggregates for bone tissue engineering using continuum methods
Geris, Liesbet ULg; Clarke, T.; Ashbourn, J.

in Middleton, J.; Jacobs, C.; Walker, B. (Eds.) et al 9th International symposium on Computer Methods in Biomechanics and Biomedical Engineering (2010)

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See detailLes méthodes de travail des historiens en Islam
Bauden, Frédéric ULg

Book published by Istituto per l'Oriente C. A. Nallino (2010)

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See detailHedge fund return specification with errors-in-variables
Coën, Alain; Hübner, Georges ULg; Desfleurs, Aurélie

in Journal of Derivatives and Hedge Funds (2010), 16(1), 22-52

In linear models for hedge fund returns, errors-in-variables may significantly alter the measurement of factor loadings and the estimation of abnormal performance. The higher moment estimator (HME ... [more ▼]

In linear models for hedge fund returns, errors-in-variables may significantly alter the measurement of factor loadings and the estimation of abnormal performance. The higher moment estimator (HME) introduced by Dagenais and Dagenais (1997) effectively deals with these issues. Results on individual funds show that the HME specification does not uncover systematic performance biases, but can modify estimated alphas in most cases and identifies relative persistence for directional funds in bearish market conditions. Overall, the risk premia calculated with HME remain relatively stable when compared to ordinary least squares specifications. [less ▲]

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See detail"Le droit des biens : une évolution indispensable sans révolution inutile"
Lecocq, Pascale ULg; Vanbrabant, Bernard ULg

in L'avenir de la recherche, Réflexions à l'occasion des leçons inaugurales 2010 (2010)

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See detailSketSha
Leclercq, Pierre ULg; Delfosse, Vincent ULg; Schroyen, Géraldine et al

Software (2010)

Detailed reference viewed: 133 (28 ULg)