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See detailStructural basis for the interaction of lactivicins with serine beta-lactamases.
Brown, Tom Jr; Charlier, Paulette ULg; Herman, Raphaël ULg et al

in Journal of Medicinal Chemistry (2010), 53(15), 5890-4

Lactivicin (LTV) is a natural non-beta-lactam antibiotic that inhibits penicillin-binding proteins and serine beta-lactamases. A crystal structure of a BS3-LTV complex reveals that, as for its reaction ... [more ▼]

Lactivicin (LTV) is a natural non-beta-lactam antibiotic that inhibits penicillin-binding proteins and serine beta-lactamases. A crystal structure of a BS3-LTV complex reveals that, as for its reaction with PBPs, LTV reacts with the nucleophilic serine and that cycloserine and lactone rings of LTV are opened. This structure, together with reported structures of PBP1b with lactivicins, provides a basis for developing improved lactivicin-based gamma-lactam antibiotics. [less ▲]

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See detailControversy about the cardiovascular safety of sibutramine.
Scheen, André ULg

in Drug Safety : An International Journal of Medical Toxicology & Drug Experience (2010), 33(7), 615-8

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See detailModeling of a Magnetic Shunt and an Aluminum Screen Using the Perturbation Finite Element Method
Ferreira da Luz, Mauricio V.; Dular, Patrick ULg; V Sabariego, Ruth ULg et al

in Proceedings of the 14th Biennial IEEE Conference on Electromagnetic Field Computation (CEFC2010) (2010)

In this paper the perturbation technique is developed for modeling of the magnetic shunt and an aluminum screen in large power transformers. The problem is first studied using either a simplified ... [more ▼]

In this paper the perturbation technique is developed for modeling of the magnetic shunt and an aluminum screen in large power transformers. The problem is first studied using either a simplified analytical or a finite element model. A more elaborated model is then defined to take into account its structural details. The calculation of iron losses and of the minimum clearance between bus bars leading current and magnetizable steel parts for a frequency range is performed. The modeling takes into account the eddy currents in magnetic shunt laminations due to the magnetic field in the shunt. [less ▲]

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See detailIdentification des menaces sur la diversité floristique des pelouses calcicoles de Belgique et opportunités pour la restauration : de l'espèce au paysage
Piqueray, Julien ULg

Doctoral thesis (2010)

Current human activities can be responsible either of the loss or promotion of biodiversity at the regional scale. The study of the influence of human activities on patterns of biological diversity is ... [more ▼]

Current human activities can be responsible either of the loss or promotion of biodiversity at the regional scale. The study of the influence of human activities on patterns of biological diversity is therefore of primary importance in order to set up conservation strategies. We studied the influence of human activities on calcareous grassland floristic diversity in Belgium. During the past century, a high fragmentation of this habitat occurred within the study region. There was a delay between the process of fragmentation and the subsequent response in terms of species richness, which created an “extinction debt” in remnant calcareous grasslands. Although fragmentation was the main process involved, we also showed that some new habitat patches were created thanks to human activities during this period. These new habitat patches exhibited a species richness and composition that was found similar to old habitat patches. In the face of fragmentation, restoration programs were launched in the study region. Restored areas exhibited similar soil conditions as compared to reference grasslands. Plant species communities found in the oldest restorations tend to resemble reference grassland communities. However, some differences in species composition persisted after 15 years. It was also shown that some species did not colonize restored sites at all. With this respect, seed and germination microsite availability could be limiting factors for the colonization of restored sites. However, the absence or the lower colonization in restored areas compared to reference grasslands following seed addition and disturbance suggested that habitat quality could be considered as lower in restored habitats. Our results suggest therefore that restoration effort should be maintain in the study site. This effort is not vain as many species are able to colonize newly created sites. Finally, another threat to calcareous grasslands was studied i.e. the naturalization of the ornamental species Cotoneaster horizontalis. The analysis revealed that, although being at an early stage of naturalization, the species had an impact on vegetation structure and composition and on grassland diversity. Trade limitation for this species should be promoted in addition to management. [less ▲]

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See detailDefault network connectivity reflects the level of consciousness in non-communicative brain-damaged patients.
Vanhaudenhuyse, Audrey ULg; Noirhomme, Quentin ULg; Tshibanda, Luaba ULg et al

in Brain : A Journal of Neurology (2010), 133(Pt 1), 161-71

The 'default network' is defined as a set of areas, encompassing posterior-cingulate/precuneus, anterior cingulate/mesiofrontal cortex and temporo-parietal junctions, that show more activity at rest than ... [more ▼]

The 'default network' is defined as a set of areas, encompassing posterior-cingulate/precuneus, anterior cingulate/mesiofrontal cortex and temporo-parietal junctions, that show more activity at rest than during attention-demanding tasks. Recent studies have shown that it is possible to reliably identify this network in the absence of any task, by resting state functional magnetic resonance imaging connectivity analyses in healthy volunteers. However, the functional significance of these spontaneous brain activity fluctuations remains unclear. The aim of this study was to test if the integrity of this resting-state connectivity pattern in the default network would differ in different pathological alterations of consciousness. Fourteen non-communicative brain-damaged patients and 14 healthy controls participated in the study. Connectivity was investigated using probabilistic independent component analysis, and an automated template-matching component selection approach. Connectivity in all default network areas was found to be negatively correlated with the degree of clinical consciousness impairment, ranging from healthy controls and locked-in syndrome to minimally conscious, vegetative then coma patients. Furthermore, precuneus connectivity was found to be significantly stronger in minimally conscious patients as compared with unconscious patients. Locked-in syndrome patient's default network connectivity was not significantly different from controls. Our results show that default network connectivity is decreased in severely brain-damaged patients, in proportion to their degree of consciousness impairment. Future prospective studies in a larger patient population are needed in order to evaluate the prognostic value of the presented methodology. [less ▲]

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See detailAppétence et adhérence des systèmes de réparation : importance de la préparation du support
Courard, Luc ULg

Conference (2010)

La compatibilité – ou appétence - entre un système de réparation et le béton support est définie à partir des propriétés du support et de la couche d’apport – essentiellement dans sa phase non liée – ... [more ▼]

La compatibilité – ou appétence - entre un système de réparation et le béton support est définie à partir des propriétés du support et de la couche d’apport – essentiellement dans sa phase non liée – ainsi que de l’environnement dans lequel le contact est créé. Elle s’exprime habituellement en termes de variations dimensionnelles, de perméabilité et de propriétés chimiques et électrochimiques. Ces propriétés sont évoquées ou développées pour chacun des matériaux mis en présence : rugosité, porosité, cohésion superficielle et eau interstitielle pour le béton ; retrait, fluage, rigidité, absorption capillaire pour les produits de réparation. Trois conditions fondamentales nécessaires et suffisantes au développement de l’adhérence en tant que signe de la compatibilité entre matériaux sont évoquées et illustrées pour le cas particulier de la préparation de surface : sablage, burinage, hydro démolition, marteau-piqueur, … ont un effet spécifique non seulement sur la rugosité, et donc l’accrochage mécanique du système de réparation, mais aussi sur la cohésion de la couche superficielle du béton [less ▲]

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See detailDiscrete Harmonic Oscillator: A Short Compendium of Formulas
Antippa, Adel F.; Dubois, Daniel ULg

in Dubois, Daniel (Ed.) COMPUTING ANTICIPATORY SYSTEMS (2010)

Since 2002, we have, in seven papers, studied the problem of the discrete harmonic oscillator, analytically, numerically, and graphically, and made progress on a number of fronts. We identified the ... [more ▼]

Since 2002, we have, in seven papers, studied the problem of the discrete harmonic oscillator, analytically, numerically, and graphically, and made progress on a number of fronts. We identified the natural frequency of oscillation of the dual incursive oscillators, studied the system bifurcation generated by incursive discretization, and the frequency dependent correlation between the resulting incursive oscillators. We also studied the synchronization of the discretizing time interval with the frequency of oscillation. From this analysis there emerged a nonlinear (or more precisely bilinear) formalism that is perfectly stable at all time scales, and fully conserves the total energy of the system. The formalism is applicable to the discrete harmonic oscillator specifically, and to discrete Hamiltonian systems in general. In retrospect the important themes and crucial steps can more easily be identified, and this is the purpose of this short note. In it we give, in a unified notation, a short compendium of the key formulas. This summary can serve as a guide for navigating through the seven papers, as well as a practical concise manual for using the formalism. [less ▲]

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See detailCassandre, un outil pour construire, confronter et expliciter les interprétations
Lejeune, Christophe ULg

in Beauvais, Martine; Clénet, Jean (Eds.) Actes du 2ème colloque international francophone sur les méthodes qualitatives (2010)

Cassandre est un logiciel libre d'analyse de textes, adossé à la plateforme collaborative Hypertopic. Fruit de la convergence épistémologique entre l'analyse qualitative (en sciences humaines) et le Web ... [more ▼]

Cassandre est un logiciel libre d'analyse de textes, adossé à la plateforme collaborative Hypertopic. Fruit de la convergence épistémologique entre l'analyse qualitative (en sciences humaines) et le Web socio-sémantique (en informatique), cet outil accompagne la construction semi-automatique du (des) cadre(s) d'analyse du (des) chercheur(s). Une série de comptes-rendus d'utilisation (tantôt collectifs tantôt isolés, plutôt inductifs ou hypothético-déductifs) attestent des apports de l'outil : génération d'un journal de bord, économie cognitive et temporelle, flexibilité, aide au travail en équipe et multiplication des entrées dans le matériau. Ces usages témoignent également des inévitables limites afférentes à l'usage d'un logiciel dans une approche qualitative. En définitive, on plaide donc pour un recours raisonné à Cassandre, comme à tout autre logiciel. [less ▲]

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See detailA cell based modelling framework for skeletal tissue engineering applications
Geris, Liesbet ULg; Van Liedekerke, Paul; Smeets, Bart et al

in Journal of Biomechanics (2010), 43(5), 887-892

In this study, a cell based lattice free modelling framework is proposed to study cell aggregate behaviour in bone tissue engineering applications. The model encompasses cell-to-cell and cell environment ... [more ▼]

In this study, a cell based lattice free modelling framework is proposed to study cell aggregate behaviour in bone tissue engineering applications. The model encompasses cell-to-cell and cell environment interactions such as adhesion, repulsion and drag forces. Oxygen, nutrients, waste products, growth factors and inhibitors are explicitly represented in the model influencing cellular behaviour. Furthermore, a model for cell metabolism is incorporated representing the basic enzymic reactions of glycolysis and the Krebs cycle. Various types of cell death such as necrosis, apoptosis and anoikis are implemented. Finally, an explicit model of the cell cycle controls the proliferation process, taking into account the presence or absence of various metabolites, sufficient space and mechanical stress. Several examples are presented demonstrating the potential of the modelling framework. The behaviour of a synchronised cell aggregate under ideal circumstances is simulated, clearly showing the different stages of the cell cycle and the resulting growth of the aggregate. Also the difference in aggregate development under ideal (normoxic) and hypoxic conditions is simulated, showing hypoxia induced necrosis mainly in the centre of the aggregate grown under hypoxic conditions. The next step in this research will be the application of this modelling framework to specific experimental set-ups for bone tissue engineering applications. (C) 2009 Elsevier Ltd. All rights reserved. [less ▲]

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See detailEvaluation des programmes de réadaptation psychiatrique proposés dans les centres de réadaptation fonctionnelle: Etude préliminaire
Limam, Sarra; Bianchi, Julien; Blairy, Sylvie ULg

in Revue Francophone de Clinique Comportementale et Cognitive (2010)

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See detailValidation of a two-plate microbiological method for screening antibiotic residues in shrimp tissue
Pham Kim, Dang ULg; Degand, Guy ULg; Danyi, Sophie ULg et al

in Analytica Chimica Acta (2010), 672

Microbiological inhibition screening tests could play an important role to detect residues of antibiotics in the different animal food products, but very few are available for the aquaculture products in ... [more ▼]

Microbiological inhibition screening tests could play an important role to detect residues of antibiotics in the different animal food products, but very few are available for the aquaculture products in general, and for shrimps in particular. A two-plate microbiological method to screen shrimp for residues of the most commonly used antibiotics has been developed and validated according to criteria derived from the European Commission Decision 2002/657/CE. Bacillus subtilis was used as a sensitive strain to target antibiotics. Culture conditions on Petri plates (pH of medium) were selected to enhance the capacity of antibiotic detection. Antibiotic residues were extracted from shrimps using acetonitrile/acetone (70/30, v/v) before application on Petri plates seeded with B. subtilis. The method was validated using spiked blank tissues as well as antibiotic treated shrimps with enrofloxacin and tetracycline, two antibiotics often found to be used in shrimp production. For tetracyclines and (fluoro)quinolones, the detection capability was below the maximum residue limit (MRL), while it was around the MRL for sulfonamides. The specificity of the microbiological screening was 100% in all cases while the sensitivity and accuracy was 100% in almost all cases. The capacity of the method to detect contaminated samples was confirmed on antibiotic treated shrimps, analyzed in parallel with a confirmatory method (Liquid Chromatography coupled to mass spectrometry (LC–MS)). [less ▲]

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See detailCOMPUTING ANTICIPATORY SYSTEMS, CASYS'09 - Ninth International Conference, Liège, Belgium, 3-8 August 2009
Dubois, Daniel ULg

Book published by American Institute of Physics (2010)

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See detailPensées sans ordre concernant la notion de 'droit fondamental'
Rosoux, Géraldine ULg

in Liège, Strasbourg, Bruxelles: parcours des droits de l'homme - Liber amicorum Michel Melchior (2010)

This article analyzes how the Belgian constitutional judge contributes to a new concept of "fundamental right".

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See detailAssessment of bovine tuberculosis risk factors based on nationwide molecular epidemiology
Humblet, Marie-France ULg; Gilbert, M.; Govaerts, M. et al

in Journal of Clinical Microbiology (2010)

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See detailWeighing risk factors associated with bee Colony Collapse Disorder by classification and regression tree Analysis
vanEngelsdorp, D.; Speybroeck, N.; Evans, J. et al

in Journal of Economic Entomology (2010)

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See detailLocal Cooperativity in an Amyloidogenic State of Human Lysozyme Observed at Atomic Resolution.
Dhulesia, A.; Cremades, N.; Kumita, J. R. et al

in Journal of the American Chemical Society (2010)

The partial unfolding of human lysozyme underlies its conversion from the soluble state into amyloid fibrils observed in a fatal hereditary form of systemic amyloidosis. To understand the molecular ... [more ▼]

The partial unfolding of human lysozyme underlies its conversion from the soluble state into amyloid fibrils observed in a fatal hereditary form of systemic amyloidosis. To understand the molecular origins of the disease, it is critical to characterize the structural and physicochemical properties of the amyloidogenic states of the protein. Here we provide a high-resolution view of the unfolding process at low pH for three different lysozyme variants, the wild-type protein and the mutants I56T and I59T, which show variable stabilities and propensities to aggregate in vitro. Using a range of biophysical techniques that includes differential scanning calorimetry and nuclear magnetic resonance spectroscopy, we demonstrate that thermal unfolding under amyloidogenic solution conditions involves a cooperative loss of native tertiary structure, followed by progressive unfolding of a compact, molten globule-like denatured state ensemble as the temperature is increased. The width of the temperature window over which the denatured ensemble progressively unfolds correlates with the relative amyloidogenicity and stability of these variants, and the region of lysozyme that unfolds first maps to that which forms the core of the amyloid fibrils formed under similar conditions. Together, these results present a coherent picture at atomic resolution of the initial events underlying amyloid formation by a globular protein. [less ▲]

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See detailTechniques de transformation, transformation des techniques
Dondero, Maria Giulia ULg; Moutat, Audrey

Book published by Presses universitaires de Limoges (PULIM) (2010)

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See detailGenetic evaluation for body condition score in the Walloon region of Belgium
Bastin, Catherine ULg; Gillon, Alain ULg; Massart, Xavier et al

in Interbull Bulletin (2010), 42

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See detailAssociation between frontal EEG asymmetries and emotional intelligence among adults
Mikolajczak, Moïra; Bodarwé, Kerrin; Laloyaux, Olivier et al

in Personality & Individual Differences (2010), 48(2), 177-181

This study aimed at investigating the brain correlates of trait emotional intelligence. Trait emotional intelligence (trait EI) is a constellation of emotion-related traits, capturing the extent to which ... [more ▼]

This study aimed at investigating the brain correlates of trait emotional intelligence. Trait emotional intelligence (trait EI) is a constellation of emotion-related traits, capturing the extent to which people experience, attend to, identify, understand, regulate, and utilize their emotions and those of others. As previous studies have provided converging evidence that frontal asymmetries were one of the determinants of emotion dispositions and behaviors, and as observations on individuals with a high level of emotional intelligence parallel those on people with a left-sided frontal cortical asymmetry in nearly every respect, we hypothesized that the level of emotional intelligence might be associated with differential frontal activation. Results supported the hypothesis: the pattern of resting electroencephalographic (EEG) activation recorded in the frontal areas was significantly associated with emotional intelligence. Individuals with higher trait EI evidence greater resting left frontal activation. [less ▲]

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