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See detailEstimating the costs of collective treatment of wastewater: the case of Walloon Region (Belgium)
Dogot, Thomas ULg; Xanthoulis, Yanni; Fonder, Nathalie et al

in Water Science & Technology (2010), 62(3), 640-648

This paper contributes to a better understanding of costs for collective wastewater treatment in the Walloon Region (Belgium). Based on a large set of data, unit costs to population equivalents are ... [more ▼]

This paper contributes to a better understanding of costs for collective wastewater treatment in the Walloon Region (Belgium). Based on a large set of data, unit costs to population equivalents are modelled. Considering investment as well as exploitation costs, the model includes not only wastewater treatment plants but also collector and sewage networks in an integrated approach at the technical basin level. Beyond this modelling, each type of process is analyzed independently in order to explore the structure of investment costs and their variation factors. Then, the model was used to forecast the upcoming expenses for 36 areas which are not yet equipped with collective wastewater treatment facilities. In light of these results, strategic choices for decision makers are discussed. [less ▲]

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See detailFast production of highly concentrated reactive [18F] fluoride for aliphatic and aromatic nucleophilic radiolabelling
Aerts, Joël ULg; Voccia, Samuel; Lemaire, Christian ULg et al

in Tetrahedron Letters (2010), 51

The use of a polymeric solid support loaded with a long alkyl chain quaternary ammonium allows the rapid and efficient recovery of cyclotron produced [18F]F- from [18O]water to a low water content organic ... [more ▼]

The use of a polymeric solid support loaded with a long alkyl chain quaternary ammonium allows the rapid and efficient recovery of cyclotron produced [18F]F- from [18O]water to a low water content organic solution compatible with fast nucleophilic labelling of most precursors for PET radiopharmaceuticals in high yield. [less ▲]

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See detailBuilding the quality into pellet manufacturing environment - feasibility study and validation of an in-line quantitative near infrared (NIR) method
Mantanus, Jérôme ULg; Ziemons, Eric ULg; Rozet, Eric ULg et al

in Talanta (2010), 83

The present study focuses on the implementation of an in-line quantitative near infrared (NIR) spectroscopic method for determining the active content of pharmaceutical pellets. The first aim was to non ... [more ▼]

The present study focuses on the implementation of an in-line quantitative near infrared (NIR) spectroscopic method for determining the active content of pharmaceutical pellets. The first aim was to non-invasively interface a dispersive NIR spectrometer with four realistic particle streams existing in the pellets manufacturing environment. Regardless of the particle stream characteristics investigated, NIR together with principal component analysis (PCA) was able to classify the samples according to their active content. Further, one of these particle stream interfaces was non-invasively investigated with a FT-NIR spectrometer. A predictive model based on Partial Least Squares (PLS) regression was able to determine the active content of pharmaceutical pellets. The NIR method was finally validated with an external validation set for an API concentration range from 80 to 120 % of the targeted active content. The prediction error of 0.9 % (root mean standard error of prediction, RMSEP) was low, indicating the accuracy of the NIR method. The accuracy profile on the validation results, an innovative approach based on tolerance intervals, demonstrated the actual and future performance of the in-line NIR method. Accordingly, the present approach paves the way for real-time release-based quality system. [less ▲]

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See detailL’édition pour la jeunesse en Belgique francophone : de la nécessité faite vertu à la mondialisation
Habrand, Tanguy ULg

in Pinhas, Luc; Foucault, Jean; Manson, Michel (Eds.) L'édition de jeunesse francophone face à la mondialisation (2010)

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See detailIntérêt d'une prise en charge multidisciplinaire ambulatoire semi-intensive dans la lombalgie chronique
Demoulin, Christophe ULg; Grosdent, Stéphanie ULg; capron, Lucile et al

in Revue du Rhumatisme (2010), 77

Objectifs. – Cette étude souhaite apprécier l’efficacité d’un programme pluridisciplinaire ambulatoire semi-intensif, élaboré en fonction des exigences des organismes mutualistes belges et destiné aux ... [more ▼]

Objectifs. – Cette étude souhaite apprécier l’efficacité d’un programme pluridisciplinaire ambulatoire semi-intensif, élaboré en fonction des exigences des organismes mutualistes belges et destiné aux patients lombalgiques chroniques. Méthodes. – Parmi 262 patients souffrant de lombalgie chronique non spécifique inclus dans cette étude, 136 (73 femmes et 63hommes présentant des douleurs depuis 11,3 ans en moyenne) ont achevé un programme ambulatoire (36 séances de deux heures) comportant une éducation à l’économie rachidienne, une approche ergonomique et psychologique ainsi que des séances de reconditionnement physique. Trois séances (initiale [séance 1], intermédiaire (séance 18) et finale [séance 36]) évaluent les paramètres d’intensité de la douleur, d’incapacité fonctionnelle, de kinésiophobie, de connaissances cognitives et gestuelles ainsi que les performances physiques (force et endurance des muscles du tronc, mobilité du complexe lombo-pelvi-fémoral, endurance cardiorespiratoire). Résultats. – Tous les paramètres sont significativement améliorés lors de l’évaluation finale : diminution de l’intensité de la douleur (−44 %), des répercussions fonctionnelles (−40 %) et de la kinésiophobie (−11 %), amélioration des connaissances (+59 %) et de la gestuelle vertébrale (+95 %), augmentation de la force des muscles du tronc (+40 % en moyenne), de l’endurance des extenseurs du tronc (+90 %), de la mobilité (+8 %) et de l’endurance cardiorespiratoire (+18 %). Conclusions. – Une prise en charge pluridisciplinaire ambulatoire semi-intensive s’avère bénéfique pour les patients lombalgiques chroniques. Une adaptation des critères d’inclusion et une implication accrue du patient dans sa rééducation contribueraient à améliorer l’observance du programme. [less ▲]

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See detailClinical evidence of benefits of a dietary supplement containing probiotic and carotenoids on ultraviolet-induced skin damage.
Bouilly-Gauthier, D.; Jeannes, C.; Maubert, Y. et al

in British Journal of Dermatology (2010)

Summary Background Lactobacillus johnsonii (La1) has been reported to protect skin immune system homeostasis following ultraviolet (UV) exposure. Objectives To assess the effects of a dietary supplement ... [more ▼]

Summary Background Lactobacillus johnsonii (La1) has been reported to protect skin immune system homeostasis following ultraviolet (UV) exposure. Objectives To assess the effects of a dietary supplement (DS) combining La1 and nutritional doses of carotenoids on early UV-induced skin damage. Methods Three clinical trials (CT1, CT2, CT3) were performed using different UV sources: nonextreme UV with a high UVA irradiance (UV-DL, CT1), extreme simulated solar radiation (UV-SSR, CT2) and natural sunlight (CT3). All three clinical trials were carried out in healthy women over 18 years of age with skin type II-IV. In CT1, early markers of UV-induced skin damage were assessed using histology and immunohistochemistry. In CT2, the minimal erythemal dose (MED) was determined by clinical evaluation and by chromametry. Chromametry was also used to evaluate skin colour. Dermatologists' and subjects' assessments were compiled in CT3. Results A 10-week DS intake prevented the UV-DL-induced decrease in Langerhans cell density and the increase in factor XIIIa+ type I dermal dendrocytes while it reduced dermal inflammatory cells. Clinical and instrumental MED rose by 20% and 19%, respectively, and skin colour was intensified, as shown by the increase in the DeltaE* parameter. The efficacy of DS was confirmed by dermatologists and subjects under real conditions of use. Conclusions Nutritional supplementation combining a specific probiotic (La1) and nutritional doses of carotenoids reduced early UV-induced skin damage caused by simulated or natural sun exposure in a large panel of subjects (n = 139). This latter result might suggest that DS intake could have a beneficial influence on the long-term effects of UV exposure and more specifically on skin photoageing. [less ▲]

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See detailDosage par GC/QQQ de huit pesticides organochlorés dans le sérum
Dubois, Nathalie ULg; Elbaz, A.; Charlier, Corinne ULg

in Acta Clinica Belgica (2010), 65(1), 58-64

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See detailLe droit européen de la concurrence au banc des accusés
Petit, Nicolas ULg

in Revue de la Faculté de Droit de l'Université de Liège (2010), (2),

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See detailAll-DNA finite-state automata with finite memory
Wang, Z. G.; Elbaz, J.; Remacle, Françoise ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2010), 107(51), 21996-22001

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See detailA robust heuristic for the optimal selection of a portfolio of stocks
Schyns, Michael ULg

in International Journal of Operational Research (2010), 9(3), 258-271

This paper introduces a new optimization heuristic for the robustification of critical inputs under consideration in many problems. It is shown that it allows to improve significantly the quality and the ... [more ▼]

This paper introduces a new optimization heuristic for the robustification of critical inputs under consideration in many problems. It is shown that it allows to improve significantly the quality and the stability of the results for two classical financial problems, i.e. the Markowitz' portfolio selection problem and the computation of the financial beta. Focus here is on the robust Minimum Covariance Determinant (MCD) estimator which can easily be substituted to the classical estimators of location and scatter. By definition, the computation of this estimator gives rise to a combinatorial optimization problem. We present a new heuristic, called 'RelaxMCD', which is based on a relaxation of the problem to the continuous space. The utility of this approach and the performance of our heuristic, with respect to other competitors, are illustrated through extensive simulations. [less ▲]

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See detailCharacteristics of Saturn’s FUV airglow from limb-viewing spectra obtained with Cassini-UVIS
Gustin, Jacques ULg; Stewart, Ian; Gérard, Jean-Claude ULg et al

in Icarus: International Journal of Solar System Studies (2010), 210

This study reports the analysis of far ultraviolet (FUV) limb spectra of the airglow of Saturn in the 1150–1850 Å spectral window, obtained with the Ultraviolet Imaging Spectrograph (UVIS) onboard Cassini ... [more ▼]

This study reports the analysis of far ultraviolet (FUV) limb spectra of the airglow of Saturn in the 1150–1850 Å spectral window, obtained with the Ultraviolet Imaging Spectrograph (UVIS) onboard Cassini, spanning altitudes from 1200 to 4000 km. The FUV limb emission consists of three main contributions: (1) H Ly-a peaking at 1100 km with a brightness of 0.8 kilo-Rayleighs (kR), (2) reflected sunlight longward of 1550 Å which maximizes at 950 km with 16.5 kR and (3) H2 bands in the 1150–1650 Å bandwidth, peaking at 1050 km reaching a maximum of 3.9 kR. A vertical profile of the local H2 volume emission rate has been derived using the hydrocarbon density profiles from a model of the Saturn equatorial atmosphere. It is well matched by a Chapman function, characterized by a maximum value of 3.5 photons cm-3 s-1 in the 800–1650 Å UV bandwidth, peaking at 1020 km. Comparisons between the observed spectra and a first-order synthetic airglow H2 model in the 1150–1650 Å bandwidth show that the spectral shape of the H2 bands is accounted for by solar fluorescence and photoelectron excitation. The best fits are obtained with a combination of H2 fluorescence lines and 20 eV electron impact spectra, the latter contributing 68% of the total H2 airglow emission. [less ▲]

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See detailTechnique d’extraction et activité antibactérienne des huiles essentielles
Benchat, N.; Amhamdi, H.; Wathelet, Jean-Paul ULg et al

Poster (2010)

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See detailComponent-resolved diagnosis in peanut and hazelnut allergy.
Gadisseur, Romy ULg; Chapelle, Jean-Paul ULg; Cavalier, Etienne ULg et al

in Allergy (2010), 65(Suppl.92), 106

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See detailFluoride PET-CT.
Hustinx, Roland ULg; Beckers, Catherine ULg

in Fanti, Stefano; Farsad, Mohsen; Mansi, Luigi (Eds.) PET-CT Beyond FDG. (2010)

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See detailHearing Preservation in Cochlear Implantation and Drug Treatment.
Barriat, Sébastien ULg; Poirrier, Anne-Lise ULg; Malgrange, Brigitte ULg et al

in Advances in Oto-Rhino-Laryngology (2010), 67

Insertion of an electrode array into the cochlea produces immediate damage to the inner ear, which is responsible for a hearing loss. In addition, a delayed hearing loss can be observed. In order to ... [more ▼]

Insertion of an electrode array into the cochlea produces immediate damage to the inner ear, which is responsible for a hearing loss. In addition, a delayed hearing loss can be observed. In order to maximize hearing preservation after insertion of an electrode and to enhance the performance of the cochlear implant, it has been proposed to deliver pharmacological agents to the inner ear. Molecules can be administered locally to the inner ear through a direct perilymphatic perfusion or through the round window membrane. These modalities of treatment have already been successfully applied to some patients with inner ear diseases. In this paper, we will review some basic aspects of drug delivery to the inner ear to prevent the degeneration of the neurosensory hair cells and auditory neurons, and the actual applicability to humans in order to maintain hearing function after the insertion of electrodes of a cochlear implant. [less ▲]

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See detailTerminologies, informatique et soins primaires. Belgique 1980-2010
Jamoulle, Marc ULg

Report (2010)

La mise en place de systèmes d’information de santé, cohérents et évolutifs, nécessite l’adoption de terminologies de référence dans le domaine de la santé. Nous examinons ici les différentes approches ... [more ▼]

La mise en place de systèmes d’information de santé, cohérents et évolutifs, nécessite l’adoption de terminologies de référence dans le domaine de la santé. Nous examinons ici les différentes approches terminologiques disponibles dans les logiciels belges, l’effort d’une terminologie centralisée connue sous le nom de 3BT, la tendance internationale autour d’un produit anglo-saxon dénommé SNOMED-CT et nous indiquons la voie qui nous parait la plus adéquate pour le développement d’une informatique médicale plus fluide dans les années à venir, condition indispensable pour l’analyse ultérieure de données de morbidité. [less ▲]

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See detailCombined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female Beagle dogs
Noël, Stéphanie; Cambier, Carole; Baert, Kris et al

in Veterinary Journal (2010)

This study investigated the differences in pharmacokinetic, urodynamic and haemodynamic parameters in female Beagle dogs in which blood sampling and urethral pressure profiles were performed over 24 h ... [more ▼]

This study investigated the differences in pharmacokinetic, urodynamic and haemodynamic parameters in female Beagle dogs in which blood sampling and urethral pressure profiles were performed over 24 h periods, after single or three times daily (T0-T6h-T12h) administration of phenylpropanolamine (PPA). Maximal concentration (Cmax) was reached 2 h after PPA administration (Tmax). The half-life lasted 4 h and, because of bioaccumulation, three times daily administration induced an increase in Cmax. Compared to the control group, a significant increase in urethral resistance was observed at Tmax after 1 week of once daily administrations. After one week of administering PPA every 6 h during the daytime, but not during the night, and despite higher plasma concentrations, the urethral resistance did not increase at any time, compared to the control group. The increase in mean arterial pressure values was compensated by a decreased heart rate. The clinical efficacy of the temporary increase in urethral resistance following single daily administration of PPA in dogs suffering from urethral sphincter mechanism incompetence (USMI) needs to be further investigated in a randomised clinical trial. [less ▲]

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