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See detail"Du Rwanda au Coeur des Ténèbres. Jean-Philippe Stassen illustre Conrad"
Demoulin, Laurent ULg

E-print/Working paper (2010)

Dans sa façon d'illustrer Coeur des ténèbres de Conrad, le dessinateur de bande dessinée Jean-Philippe Stassen interprète de façon très personnelle l'oeuvre du romancier. La bande dessinée se déclare ici ... [more ▼]

Dans sa façon d'illustrer Coeur des ténèbres de Conrad, le dessinateur de bande dessinée Jean-Philippe Stassen interprète de façon très personnelle l'oeuvre du romancier. La bande dessinée se déclare ici aussi légitime que la littérature. [less ▲]

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See detailIII-V Devices for Advanced CMOS
Waldron, Niamh; Nguyen, Ngoc Duy ULg; Lin, Dennis et al

in 217th ECS Meeting (2010)

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See detailSemi-solid metallic alloys modeling for the simulation of thixoforming processes
Koeune, Roxane ULg; Ponthot, Jean-Philippe ULg

in Vaz Jr., M.; de Souza Neto, E. A.; Munoz-Rojas, P. A. (Eds.) Computational Materials Modeling (2010)

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See detailL'administration provisoire
Deguel, François ULg

in Leleu, Yves-Henri (Ed.) Chroniques notariales (2010)

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See detailEvaluation of a set of E. coli reporter strains as physiological tracer for estimating bioreactor hydrodynamic efficiency
Delvigne, Frank ULg; Ingels, Sophie; Thonart, Philippe ULg

in Process Biochemistry (2010), 45(11), 1769-1778

A set of different green fluorescent protein (GFP) Escherichia coli reporter strains have been evaluated in mini- and stirred bioreactors operating in fed-batch mode with different degrees of ... [more ▼]

A set of different green fluorescent protein (GFP) Escherichia coli reporter strains have been evaluated in mini- and stirred bioreactors operating in fed-batch mode with different degrees of perturbations in order to estimate their potential use as process-related stress biosensor. The mini-bioreactor platform comprises a set of parallel shake flasks operating in fed-batch mode. The advantage of this system is its high experimental throughput for the evaluation of the GFP synthesis capacity of our reporter strains. In the case of classical shake flask system, no significant evolution of GFP synthesis have been observed, considering the reduced microbial growth period allowed by the system, whereas in the case of fed-batch operated mini-bioreactors, evolution of GFP synthesis, as well as GFP distribution among the microbial population, has been observed for three preselected strains (prpoS, puspA and posmC::gfp). More interestingly, a binary mode of expression has been observed in the case of the cultures carried out with the reporter strains for which GFP synthesis is under the control of the rpoS promoter which is induced under carbon limitation conditions. However, the generation of controlled glucose perturbations is relatively limited in this system and, in a second step fully automated bioreactor with a sclae-down strategy has been used to correlate the response of a prpoS::gfp strains with extracellular glucose perturbations. In the case of the culture performed in perturbed bioreactor (glucose intermittent feeding or glucose addition at the level of the recycle loop of a two-compartment scale-down bioreactor), the slowdown of the GFP synthesis resulting in the observation of a binary repartition of GFP content among the microbial population, has been observed. This observation led to the conclusion that the prpoS::gfp can be used as a biosensor for the validation of a fed-batch profile in industrial-scale bioreactors. [less ▲]

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See detailLes cultes isiaques à Emporion
Puccio, Laetizia ULg

in Pallas : Revue d'Etudes Antiques (2010), 84

This article presents a new interpretation of the temple M's content placed in the so-called sanctuary of Asklepios in Emporion. The sculptures are related to an inscription of the area and also to a ... [more ▼]

This article presents a new interpretation of the temple M's content placed in the so-called sanctuary of Asklepios in Emporion. The sculptures are related to an inscription of the area and also to a sigilado glass and chandeliers that come from the Roman city. All this proves the presence of an Egyptian worship in Emporion more complex than earlier. [less ▲]

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See detailJean-Philippe Toussaint
Demoulin, Laurent ULg; Piret, Pierre

in Textyles : Revue des Lettres Belges de Langue Française (2010), 38

L'œuvre de Jean-Philippe Toussaint n'a à ce jour donné lieu à aucune publication monographique en français. Textyles a voulu remédier à cette lacune, en mettant en chantier un numéro pionnier et, à ce ... [more ▼]

L'œuvre de Jean-Philippe Toussaint n'a à ce jour donné lieu à aucune publication monographique en français. Textyles a voulu remédier à cette lacune, en mettant en chantier un numéro pionnier et, à ce titre, résolument ouvert : mettre en perspective les différentes facettes de l’œuvre en multipliant les angles d’approche, tel fut l’objectif qui présida à l’élaboration du présent dossier. Spécialistes des études littéraires, du cinéma et de la photographie s’y côtoient, qui développent des analyses s’attachant à dégager les modes de composition et les principales caractéristiques esthétiques de l’œuvre, à montrer comment elle radiographie les discours contemporains et à la situer dans l’histoire de la littérature. [less ▲]

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See detailCotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning.
Baron, Frédéric ULg; Lechanteur, Chantal ULg; Willems, Evelyne ULg et al

in Biology of Blood & Marrow Transplantation (2010), 16(6), 838-47

Recent studies have suggested that coinfusion of mesenchymal stem cells (MSCs) the day of hematopoietic cell transplantation (HCT) might promote engraftment and prevent graft-versus-host disease (GVHD ... [more ▼]

Recent studies have suggested that coinfusion of mesenchymal stem cells (MSCs) the day of hematopoietic cell transplantation (HCT) might promote engraftment and prevent graft-versus-host disease (GVHD) after myeloablative allogeneic HCT. This prompted us to investigate in a pilot study whether MSC infusion before HCT could allow nonmyeloablative (NMA) HCT (a transplant strategy based nearly exclusively on graft-versus-tumor effects for tumor eradication) from HLA-mismatched donors to be performed safely. Twenty patients with hematologic malignancies were given MSCs from third party unrelated donors 30-120 minutes before peripheral blood stem cells (PBSCs) from HLA-mismatched unrelated donors, after conditioning with 2 Gy total body irradiation (TBI) and fludarabine. The primary endpoint was safety, defined as a 100-day incidence of nonrelapse mortality (NRM) <35%. One patient had primary graft rejection, whereas the remaining 19 patients had sustained engraftment. The 100-day cumulative incidence of grade II-IV acute GVHD (aGVHD) was 35%, whereas 65% of the patients experienced moderate/severe chronic GVHD (cGVHD). One-year NRM (10%), relapse (30%), overall survival (OS) (80%) and progression-free survival (PFS) (60%), and 1-year incidence of death from GVHD or infection with GVHD (10%) were encouraging. These figures compare favorably with those observed in a historic group of 16 patients given HLA-mismatched PBSCs (but no MSCs) after NMA conditioning, which had a 1-year incidence of NRM of 37% (P = .02), a 1-year incidence of relapse of 25% (NS), a 1-year OS and PFS of 44% (P = .02), and 38% (P = .1), respectively, and a 1-year rate of death from GVHD or infection with GVHD of 31% (P = .04). In conclusion, our data suggest that HLA-mismatched NMA HCT with MSC coinfusion appeared to be safe. [less ▲]

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See detailLouvre-Lens : Le Louvre autrement : des coulisses aux expositions
Bodéré, Audrey; Drouguet, Noémie ULg

in CeROArt : Conservation, Exposition, Restauration d'Objets d'Art (2010), 5

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See detailQui dispose des dispositifs de médiation ?
Servais, Christine ULg

in Questions de Communication (2010), 10

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See detailFibrin glue is effective healing perianal fistulas in patients with Crohn's disease.
Grimaud, Jean-Charles; Munoz-Bongrand, Nicolas; Siproudhis, Laurent et al

in Gastroenterology (2010), 138(7), 2275-8122811

BACKGROUND & AIMS: Fibrin glue is a therapeutic for fistulas that activates thrombin to form a fibrin clot, which mechanically seals the fistula tract. We assessed the efficacy and safety of a ... [more ▼]

BACKGROUND & AIMS: Fibrin glue is a therapeutic for fistulas that activates thrombin to form a fibrin clot, which mechanically seals the fistula tract. We assessed the efficacy and safety of a heterologous fibrin glue that was injected into the fistula tracts of patients with Crohn's disease (ClinicalTrials.gov No. NCT00723047). METHODS: This multicenter, open-label, randomized controlled trial included patients with a Crohn's disease activity index < or =250 and fistulas between the anus (or low rectum) and perineum, vulva, or vagina, that drained for more than 2 months. Magnetic resonance imaging or endosonography was performed to assess fistula tracts and the absence of abscesses. Patients were stratified into groups with simple or complex fistulas and randomly assigned to receive fibrin glue injections (n = 36) or only observation (n = 41) after removal of setons. The primary end point was clinical remission at week 8, defined as the absence of draining, perianal pain, or abscesses. At week 8, a fibrin glue injection was offered to patients who were not in remission. RESULTS: Clinical remission was observed in 13 of the 34 patients (38%) of the fibrin glue group compared with 6 of the 37 (16%) in the observation group; these findings demonstrate the benefit of fibrin glue (odds ratio, 3.2; 95% confidence interval: 1.1-9.8; P = .04). The benefit seemed to be greater in patients with simple fistulas. Four patients in the fibrin glue group and 6 in the observation group had adverse events. CONCLUSIONS: Fibrin glue injection is a simple, effective, and well-tolerated therapeutic option for patients with Crohn's disease and perianal fistula tracts. [less ▲]

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See detailEvaluation of bromocriptine in the treatment of acute severe peripartum cardiomyopathy: a proof-of-concept pilot study.
Sliwa, Karen; Blauwet, Lori; Tibazarwa, Kemi et al

in Circulation (2010), 121(13), 1465-73

BACKGROUND: Peripartum cardiomyopathy (PPCM) is a potentially life-threatening heart disease that occurs in previously healthy women. We identified prolactin, mainly its 16-kDa angiostatic and ... [more ▼]

BACKGROUND: Peripartum cardiomyopathy (PPCM) is a potentially life-threatening heart disease that occurs in previously healthy women. We identified prolactin, mainly its 16-kDa angiostatic and proapoptotic form, as a key factor in PPCM pathophysiology. Previous reports suggest that bromocriptine may have beneficial effects in women with acute onset of PPCM. METHODS AND RESULTS: A prospective, single-center, randomized, open-label, proof-of-concept pilot study of women with newly diagnosed PPCM receiving standard care (PPCM-Std; n=10) versus standard care plus bromocriptine for 8 weeks (PPCM-Br, n=10) was conducted. Because mothers receiving bromocriptine could not breast-feed, the 6-month outcome of their children (n=21) was studied as a secondary end point. Blinded clinical, hemodynamic, and echocardiographic assessments were performed at baseline and 6 months after diagnosis. Cardiac magnetic resonance imaging was performed 4 to 6 weeks after diagnosis in PPCM-Br patients. There were no significant differences in baseline characteristics, including serum 16-kDa prolactin levels and cathepsin D activity, between the 2 study groups. PPCM-Br patients displayed greater recovery of left ventricular ejection fraction (27% to 58%; P=0.012) compared with PPCM-Std patients (27% to 36%) at 6 months. One patient in the PPCM-Br group died compared with 4 patients in the PPCM-Std group. Significantly fewer PPCM-Br patients (n=1, 10%) experienced the composite end point of poor outcome defined as death, New York Heart Association functional class III/IV, or left ventricular ejection fraction <35% at 6 months compared with the PPCM-Std patients (n=8, 80%; P=0.006). Cardiac magnetic resonance imaging revealed no intracavitary thrombi. Infants of mothers in both groups showed normal growth and survival. CONCLUSIONS: In this trial, the addition of bromocriptine to standard heart failure therapy appeared to improve left ventricular ejection fraction and a composite clinical outcome in women with acute severe PPCM, although the number of patients studied was small and the results cannot be considered definitive. Larger-scale multicenter and blinded studies are in progress to test this strategy more robustly. [less ▲]

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See detailLes remparts de l'intime: hypothèse sur les non-dits dans le processus de (méta-)révélation chez l'enfant victime d'abus sexuel
Bullens, Quentin ULg

in Psychiatrie de l'Enfant (La) (2010), LIII(2), 431-452

When a child victim of sexual abuse tells us that he has not said everything, it may be tempting to try to pierce the secret, to encourage him to get it off his chest once and for all, as some parents ... [more ▼]

When a child victim of sexual abuse tells us that he has not said everything, it may be tempting to try to pierce the secret, to encourage him to get it off his chest once and for all, as some parents suggest. However, our wish has been to take the reader toward another perception of these things left unsaid. First of all, by defining several variables which make it possible to evaluate the meta-aspect of such revelations. Then, by interesting ourselves in what this meta-revelation tells us avout the child's state, but also about the state of the therapeutic process in relation to Winnicott's contribution. Finally, thinking about the way in which such a process should be approached so as not to neglect the child's declarations but so as not to risk causing more violence toward what may have been the most precious thing for him at the moment of the torment following his revelation. [less ▲]

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See detailPyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-kappaB activation.
Mortier, Jeremie; Frederick, Raphael; Ganeff, Corinne et al

in Biochemical Pharmacology (2010), 79(10), 1462-72

In this work, we aimed to build a 3D-model of NIK and to study the binding of pyrazolo[4,3-c]isoquinolines with a view to highlight the structural elements responsible for their inhibitory potency ... [more ▼]

In this work, we aimed to build a 3D-model of NIK and to study the binding of pyrazolo[4,3-c]isoquinolines with a view to highlight the structural elements responsible for their inhibitory potency. However, in the course of this work, we unexpectedly found that the pyrazolo[4,3-c]isoquinolines initially reported as NIK inhibitors were neither inhibitors of this enzyme nor of the alternative NF-kappaB pathway, but were in fact inhibitors of another kinase, the TGF-beta activated kinase 1 (TAK1) which is involved in the classical NF-kappaB pathway. [less ▲]

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See detailFollicular fluids, immunological fingerprint and infertility
Lédée, N; Munaut, Carine ULg; PERRIER d'HAUTERIVE, Sophie ULg et al

Conference (2010)

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See detailMaternal plasma soluble endoglin at 11-13 weeks's gestation in pre-eclampsia
Foidart, Jean-Michel ULg; Munaut, Carine ULg; Chantraine, Frédéric ULg et al

in Ultrasound in Obstetrics & Gynecology (2010), 35(6), 680-7

Objectives: To examine the performance of screening for preeclampsia (PE) by a combination of maternal factors, soluble endoglin (sEng), pregnancy associated plasma protein A (PAPP-A), placental growth ... [more ▼]

Objectives: To examine the performance of screening for preeclampsia (PE) by a combination of maternal factors, soluble endoglin (sEng), pregnancy associated plasma protein A (PAPP-A), placental growth factor (PlGF) and uterine artery lowest pulsatibility index (L-PI) at 11-13 weeks of gestation. Methods: Uterine artery L-PI, sEng, PAPP-A and PlGF were measured at 11-13 weeks in 90 singleton pregnancies that subsequently developed PE, including 30 that required delivery before 34 weeks (early-PE) and 60 with late-PE, and 180 unaffected controls. Screening performance for PE by maternal factors, sEng, PAPP-A, PlGF and uterine artery L-PI and their combinations was determined. Results: In early-PE, compared to controls, plasma sEng and uterine L-PI were significantly increased and serum PAPP-A and PlGF were decreased. In late-PE, compared to controls, serum PlGF was decreased and uterine L-PI was increased but plasma sEng and serum PAPP-A were not significantly different. In screening for early-PE, the detection rate at a 10% false positive rate was 46.7% for sEng alone and 96.3% for a combination of maternal factors, sEng, PlGF and uterine artery L-PI. Conclusions: Effective screening for early-PE can be provided by a combination of maternal factors, sEng, PlGF and uterine artery L-PI at 11-13 weeks. [less ▲]

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See detailIntroduction
Drouguet, Noémie ULg

in CeROArt : Conservation, Exposition, Restauration d'Objets d'Art (2010), 5

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See detailExperimental investigation of the effect of flip bucket splitters on plunge pool geometry
Erpicum, Sébastien ULg; Archambeau, Pierre ULg; Dewals, Benjamin ULg et al

in RWTH - IWW (Ed.) Mitteilungen - 15. Deutsches Talsperrensymposium - Talsperren im Wandel (2010)

Flip buckets are common hydraulic structures aiming at deflecting high velocity flows to a free jet trajectory. Systematic experimental tests have been performed to assess the influence on energy ... [more ▼]

Flip buckets are common hydraulic structures aiming at deflecting high velocity flows to a free jet trajectory. Systematic experimental tests have been performed to assess the influence on energy dissipation and the plunge pool geometry of varied repartitions of splitters along the flip bucket width. In particular, it is shown that some configurations can create more erosion than a continuous channel without flip bucket. [less ▲]

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