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See detailCombined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female Beagle dogs
Noël, Stéphanie; Cambier, Carole; Baert, Kris et al

in Veterinary Journal (2010)

This study investigated the differences in pharmacokinetic, urodynamic and haemodynamic parameters in female Beagle dogs in which blood sampling and urethral pressure profiles were performed over 24 h ... [more ▼]

This study investigated the differences in pharmacokinetic, urodynamic and haemodynamic parameters in female Beagle dogs in which blood sampling and urethral pressure profiles were performed over 24 h periods, after single or three times daily (T0-T6h-T12h) administration of phenylpropanolamine (PPA). Maximal concentration (Cmax) was reached 2 h after PPA administration (Tmax). The half-life lasted 4 h and, because of bioaccumulation, three times daily administration induced an increase in Cmax. Compared to the control group, a significant increase in urethral resistance was observed at Tmax after 1 week of once daily administrations. After one week of administering PPA every 6 h during the daytime, but not during the night, and despite higher plasma concentrations, the urethral resistance did not increase at any time, compared to the control group. The increase in mean arterial pressure values was compensated by a decreased heart rate. The clinical efficacy of the temporary increase in urethral resistance following single daily administration of PPA in dogs suffering from urethral sphincter mechanism incompetence (USMI) needs to be further investigated in a randomised clinical trial. [less ▲]

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See detailRecollection and familiarity memory processes in probable Alzheimer's disease: an fMRI study
Genon, Sarah ULg; Salmon, Eric ULg; Collette, Fabienne ULg et al

Scientific conference (2010)

Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during ... [more ▼]

Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during performance of a recognition memory task with the process dissociation procedure. Brain regions associated to recollection were evidenced by contrasting activations for inclusion and exclusion conditions whereas brain regions related to familiarity were explored with the mean effect of the two conditions (at P < .05 corrected). Twelve patients had null recollection estimates (AD-), whereas 16 patients did experience some recollection although significantly less than controls (AD+). In AD+ and controls, recollection activated the posterior cingulate cortex (PCC). In contrast, familiarity estimates were equivalent in the 3 groups and were associated with brain activations around the intraparietal sulcus (IPS). Thus, in AD, impaired recollection is related to damage of the PCC whereas preserved familiarity is supported by the IPS. [less ▲]

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See detailL’adolescent porteur d'une trisomie 21 : processus d’apprentissage et compétences cognitives
Frenkel, Stéphanie ULg; Detraux, Jean-Jacques ULg

in Haelewyck, Marie-Claire; Gascon, Hubert (Eds.) Adolescence et retard mental (2010)

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See detailMaqriziana XI. Al-Maqrīzī et al-Ṣafadī: analyse de la (re)construction d'un récit biographique
Bauden, Frédéric ULg

in Quaderni di Studi Arabi (2010), 4(2009), 99-136

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See detailFlow of magnetized grains in a rotating drum
Lumay, Geoffroy ULg; Vandewalle, Nicolas ULg

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2010)

We have experimentally investigated the influence of a magnetic interaction between the grains on the flow of a granular material in a rotating drum.

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See detailLes méthodes de travail des historiens en Islam
Bauden, Frédéric ULg

Book published by Istituto per l'Oriente C. A. Nallino (2010)

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See detailSketSha
Leclercq, Pierre ULg; Delfosse, Vincent ULg; Schroyen, Géraldine et al

Software (2010)

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See detail"Le droit des biens : une évolution indispensable sans révolution inutile"
Lecocq, Pascale ULg; Vanbrabant, Bernard ULg

in L'avenir de la recherche, Réflexions à l'occasion des leçons inaugurales 2010 (2010)

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See detailMolecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation.
Yevenes, Gonzalo E; Moraga-Cid, Gustavo; Avila, Ariel et al

in Journal of Biological Chemistry (2010), 285(39), 30203-13

It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure. Thus, the differential ethanol ... [more ▼]

It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure. Thus, the differential ethanol sensitivity of diverse GlyR isoforms and mutants was explained by the presence of specific residues in putative alcohol pockets. Here, we demonstrate that ethanol sensitivity in two ligand-gated ion receptor members, the GlyR adult alpha(1) and embryonic alpha(2) subunits, can be modified through selective mutations that rescued or impaired Gbetagamma modulation. Even though both isoforms were able to physically interact with Gbetagamma, only the alpha(1) GlyR was functionally modulated by Gbetagamma and pharmacological ethanol concentrations. Remarkably, the simultaneous switching of two transmembrane and a single extracellular residue in alpha(2) GlyRs was enough to generate GlyRs modulated by Gbetagamma and low ethanol concentrations. Interestingly, although we found that these TM residues were different to those in the alcohol binding site, the extracellular residue was recently implicated in conformational changes important to generate a pre-open-activated state that precedes ion channel gating. Thus, these results support the idea that the differential ethanol sensitivity of these two GlyR isoforms rests on conformational changes in transmembrane and extracellular residues within the ion channel structure rather than in differences in alcohol binding pockets. Our results describe the molecular basis for the differential ethanol sensitivity of two ligand-gated ion receptor members based on selective Gbetagamma modulation and provide a new mechanistic framework for allosteric modulations of abuse drugs. [less ▲]

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See detailL'exraction par micro-ondes: un choix de qualité
Ramdani, M.; Ghazi, Z.; Fadel, O. et al

Poster (2010)

Le but de ce travail est de comparer l’extraction faite par chauffage classique (CC) avec celle réalisée sous micro-ondes (MO). Deux modes d’extraction ont été réalisés : - L’hydro-distillation par ... [more ▼]

Le but de ce travail est de comparer l’extraction faite par chauffage classique (CC) avec celle réalisée sous micro-ondes (MO). Deux modes d’extraction ont été réalisés : - L’hydro-distillation par chauffage classique (extraction par entraînement à la vapeur d’un solvant) et, - L’hydro-distillation activée par micro-ondes. Les MO permettent un gain de temps considérable. Par exemple, dans le cas du lavandula dentata : on note une cinétique 3 fois plus rapide, de plus le rendement est nettement supérieur (1% contre 0,6% par chauffage classique). Dans le cas de la plante fraiche, l’extraction est faite en absence de solvant sous MO. Ceci présente un grand intérêt sur le plan économique et environnemental. De plus, la qualité de l’huile extraite présente généralement une meilleure pureté. L’extraction par MO constitue une technique en accord avec la chimie verte. Grâce à ce procédé, on pourra alors réduire d'environ 60 % les besoins en énergie, ce qui diminuera d'autant les émissions de gaz à effet de serre. [less ▲]

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See detailA hybrid model for the simulation of angiogenesis during bone fracture healing
Geris, Liesbet ULg; Peiffer, Veronique; Gerisch, Alf et al

in Proceedings of the 17th conference of the European Society of Biomechanics (2010)

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See detailPieds et empreintes de pieds dans les cultes isiaques. Pour une meilleure compréhension des documents hispaniques
Puccio, Laetizia ULg

in Melanges de la Casa de Velazquez (2010), 40(2), 137-155

L’étude des cultes isiaques dans la péninsule Ibérique donne à connaître une série de documents qui représentent un pied sous sa forme réelle ou gravé sur des stèles votives. Se pose alors la question de ... [more ▼]

L’étude des cultes isiaques dans la péninsule Ibérique donne à connaître une série de documents qui représentent un pied sous sa forme réelle ou gravé sur des stèles votives. Se pose alors la question de l’origine de ce symbole. Apparenté aux divinités égyptiennes, il est synonyme de richesse et d’abondance dans la religion pharaonique. À partir de la vallée du Nil, les deux modèles se sont diffusés dans le monde méditerranéen et ils ont atteint l’Hispanie au IIe siècle en passant sans doute par le continent africain. Sans aucune référence dans la littérature antique, l’enquête menée autour de ces représentations et de leurs différentes déclinaisons n’autorise pas à leur attribuer une seule signification. Les pieds de Sérapis comme les stèles dédiées à Isis incarnent le plus souvent l’épiphanie divine, mais ils peuvent également être considérés comme de simples témoignages de dévotion. Lorsque les empreintes de pieds correspondent à celles de la déesse et que les stèles sont situées devant l’entrée du temple, elles pourraient faire référence à un rituel d’accueil. [less ▲]

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See detailMathematical modelling of cell aggregates for bone tissue engineering using continuum methods
Geris, Liesbet ULg; Clarke, T.; Ashbourn, J.

in Middleton, J.; Jacobs, C.; Walker, B. (Eds.) et al 9th International symposium on Computer Methods in Biomechanics and Biomedical Engineering (2010)

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See detailA grid for a precise analysis of daily activities
Wojtasik, Vinciane ULg; Olivier, Catherine ULg; Lekeu, Françoise ULg et al

in Neuropsychological Rehabilitation (2010), 20

Assessment of daily living activities is essential in patients with Alzheimer's disease. Most current tools quantitatively assess overall ability but provide little qualitative information on individual ... [more ▼]

Assessment of daily living activities is essential in patients with Alzheimer's disease. Most current tools quantitatively assess overall ability but provide little qualitative information on individual difficulties. Only a few tools allow therapists to evaluate stereotyped activities and record different types of errors. We capitalised on the Kitchen Activity Assessment to design a widely applicable analysis grid that provides both qualitative and quantitative data on activity performance. A cooking activity was videotaped in 15 patients with dementia and assessed according to the different steps in the execution of the task. The evaluations obtained with our grid showed good correlations between raters, between versions of the grid and between sessions. Moreover, the degree of independence obtained with our analysis of the task correlated with the Kitchen Activity Assessment score and with a global score of cognitive functioning. We conclude that assessment of a daily living activity with this analysis grid is reproducible and relatively independent of the therapist, and thus provides quantitative and qualitative information useful for both evaluating and caring for demented patients. [less ▲]

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See detailHydro-mechanical modelling of the Excavation Damaged Zone around an underground excavation at Mont Terri Rock Laboratory
Levasseur, Séverine ULg; Charlier, Robert ULg; Frieg, Bernd et al

in International Journal of Rock Mechanics & Mining Sciences (2010), 47(3), 414-425

A zone with significant irreversible deformations and significant changes in flow and transport properties is expected to be formed in indurated clay around underground excavations. The stress ... [more ▼]

A zone with significant irreversible deformations and significant changes in flow and transport properties is expected to be formed in indurated clay around underground excavations. The stress perturbation around the excavation could lead to a significant increase of the permeability, related to diffuse and/or localized crack propagation in the material. The main objective of the study is to model these processes at large scale in order to assess their impacts on the performance of radioactive waste geological repositories. This paper concerns more particularly the hydro-mechanical modelling of a long term dilatometer experiment performed in Mont Terri Rock Laboratory in Switzerland within the Selfrac Project. The proposed model defines the permeability as a function of the aperture of the cracks that are generated during the excavation. With this model, the permeability tensor becomes anisotropic. Advantages and drawbacks of this approach are described thanks to the results of the Selfrac long term dilatometer experiment. [less ▲]

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See detailThe impact of concomitant rhinitis on asthma-related quality of life and asthma control.
Vandenplas, O.; Dramaix, M.; Joos, G. et al

in Allergy (2010)

To cite this article: Vandenplas O, Dramaix M, Joos G, Louis R, Michils A, Verleden G, Vincken W, Vints A-M, Herbots E, Bachert C. The impact of concomitant rhinitis on asthma-related quality of life and ... [more ▼]

To cite this article: Vandenplas O, Dramaix M, Joos G, Louis R, Michils A, Verleden G, Vincken W, Vints A-M, Herbots E, Bachert C. The impact of concomitant rhinitis on asthma-related quality of life and asthma control. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02365.x. Abstract Background: Characterizing the interactions between the upper and lower airways is important for the management of asthma. This study aimed at assessing the specific impact of concomitant rhinitis on asthma-related quality of life (QOL) and asthma control. Methods: A cross-sectional, observational survey was conducted among 1173 patients with asthma (aged 12-45) recruited by general practitioners and chest physicians. AR was defined by self-reported rhinitis symptoms and previously documented sensitization to inhalant allergens. The primary outcomes were (1) asthma control assessed by the Asthma Control Questionnaire (ACQ) and (2) asthma-specific QOL evaluated through the Mini Asthma Quality of Life Questionnaire (mAQLQ). Results: AR was present in 73.9% of the population with asthma and nonallergic rhinitis (NAR) in 13.6%. AR and NAR were associated with an increased risk of uncontrolled asthma (i.e. ACQ score > 1.5) with adjusted odds ratios (OR) of 2.00 (95% confidence interval [CI]: 1.35-2.97) and 1.77 (95%CI: 1.09-2.89), respectively. Multivariate linear regression analysis showed that AR and NAR had a modest, although significant, negative impact on the global mAQLQ score (beta coefficient: -0.293, standard error [SE]: 0.063 and beta coefficient: -0.221, SE: 0.080, P < 0.001, respectively), even after adjustment for the level of asthma control and demographic characteristics. Conclusion: This survey provides direct evidence that AR and NAR are associated with an incremental adverse impact on the disease-specific QOL of patients with asthma and the level of asthma control. Further investigations are required to determine whether appropriate treatment of rhinitis would efficiently reduce asthma morbidity. [less ▲]

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