References of "2010"
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See detailStress Doppler echocardiography in valvular heart diseases: utility and assessment.
O'Connor, Kim; LANCELLOTTI, Patrizio ULg; Pierard, Luc ULg

in Future Cardiology (2010), 6(5), 611-25

This article is a review on the role of stress echocardiography in valvular heart diseases, describing what the validated indications are, how to perform the test and the utility of performing this ... [more ▼]

This article is a review on the role of stress echocardiography in valvular heart diseases, describing what the validated indications are, how to perform the test and the utility of performing this examination. Most valve diseases are characteristically dynamic and this dynamic component is best appreciated by exercise Doppler echocardiography. Dobutamine stress echocardiography is also useful in patients with severe aortic stenosis and left ventricular dysfunction. The main advantage of stress echocardiography is to concomitantly allow the evaluation of symptoms, exercise capacity and the hemodynamic consequences of valve diseases, especially in patients with severe valve diseases who deny symptoms or present equivocal symptoms. It also provides important prognostic information and may help to optimize surgical timing in difficult cases. Whether these data should be integrated in the management of patients needs further validation. [less ▲]

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See detailStrategies pour eviter l'inertie et la non-observance dans les essais cliniques.
Jandrain, Bernard ULg; Ernest, Philippe ULg; Radermecker, Régis ULg et al

in Revue Médicale de Liège (2010), 65(5-6), 246-9

Randomised controlled trials play a key role in evidence-based medicine as far as the assessment of both efficacy and safety of drugs is concerned. Various strategies are used to avoid physician's inertia ... [more ▼]

Randomised controlled trials play a key role in evidence-based medicine as far as the assessment of both efficacy and safety of drugs is concerned. Various strategies are used to avoid physician's inertia and to combat patient's non compliance, two pitfalls that may hinder the demonstration of the therapeutic efficacy of the drug. Clinical inertia may be limited by titration, forced or optional, driven by therapeutic targets, or by the use, if necessary, of rescue medications. Compliance may be verified by "pill count". This simple technique allows to exclude non compliant patients when they are detected during the placebo run-in period before randomisation or not to take into account patients with poor compliance in the final evaluation by using a statistical analysis restricted to individuals who have strictly adhered to the study protocol ("per protocol analysis"). Self-monitoring and patient's empowerment in the treatment also contribute to improve drug compliance. Clinicians may take advantage of these approaches derived from clinical trials to improve their daily practice. [less ▲]

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See detailPortfolio professionnel : Projet personnel :Enseignement de la nutrition en médecine vétérinaire : un projet d'exercices en ligne visant à susciter l'apprentissage pré-clinique et l'autonomie
Diez, Marianne ULg

Learning material (2010)

Portfolio présentant l'enseignement et une innovation pédagogique sous forme de 2 articles

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See detailIdentité et culture en Europe
Jamin, Jérôme ULg

Article for general public (2010)

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See detailStructure and properties of a complex of alpha-synuclein and a single-domain camelid antibody.
De Genst, Erwin J; Guilliams, Tim; Wellens, Joke et al

in Journal of Molecular Biology (2010), 402(2), 326-43

The aggregation of the intrinsically disordered protein alpha-synuclein to form fibrillar amyloid structures is intimately associated with a variety of neurological disorders, most notably Parkinson's ... [more ▼]

The aggregation of the intrinsically disordered protein alpha-synuclein to form fibrillar amyloid structures is intimately associated with a variety of neurological disorders, most notably Parkinson's disease. The molecular mechanism of alpha-synuclein aggregation and toxicity is not yet understood in any detail, not least because of the paucity of structural probes through which to study the behavior of such a disordered system. Here, we describe an investigation involving a single-domain camelid antibody, NbSyn2, selected by phage display techniques to bind to alpha-synuclein, including the exploration of its effects on the in vitro aggregation of the protein under a variety of conditions. We show using isothermal calorimetric methods that NbSyn2 binds specifically to monomeric alpha-synuclein with nanomolar affinity and by means of NMR spectroscopy that it interacts with the four C-terminal residues of the protein. This latter finding is confirmed by the determination of a crystal structure of NbSyn2 bound to a peptide encompassing the nine C-terminal residues of alpha-synuclein. The NbSyn2:alpha-synuclein interaction is mediated mainly by side-chain interactions while water molecules cross-link the main-chain atoms of alpha-synuclein to atoms of NbSyn2, a feature we believe could be important in intrinsically disordered protein interactions more generally. The aggregation behavior of alpha-synuclein at physiological pH, including the morphology of the resulting fibrillar structures, is remarkably unaffected by the presence of NbSyn2 and indeed we show that NbSyn2 binds strongly to the aggregated as well as to the soluble forms of alpha-synuclein. These results give strong support to the conjecture that the C-terminal region of the protein is not directly involved in the mechanism of aggregation and suggest that binding of NbSyn2 could be a useful probe for the identification of alpha-synuclein aggregation in vitro and possibly in vivo. [less ▲]

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See detailThe effectiveness of inpatient geriatric evaluation and management units: a systematic review and meta-analysis.
Van Craen, Katleen; Braes, Tom; Wellens, Nathalie et al

in Journal of the American Geriatrics Society (2010), 58(1), 83-92

OBJECTIVES: To examine how geriatric evaluation and management units (GEMUs) are organized and to examine the effectiveness of admission on a GEMU. DESIGN: Systematic review and meta-analysis based on ... [more ▼]

OBJECTIVES: To examine how geriatric evaluation and management units (GEMUs) are organized and to examine the effectiveness of admission on a GEMU. DESIGN: Systematic review and meta-analysis based on literature search of multiple databases and the references lists of all identified articles and by contacting authors. SETTING: GEMUs. PARTICIPANTS: Elderly people admitted to a GEMU. MEASUREMENTS: Quality of the studies was assessed on 10 criteria. The outcome parameters were mortality, institutionalization, functional decline, readmission, and length of stay at different follow-up points. A random-effects meta-analysis was performed using Hedges' gu and variance of relative risk (RR). RESULTS: GEMUs are organized in a heterogeneous way and the included studies gave no thorough description of comprehensive geriatric assessment (CGA). Involvement of a multidisciplinary team was a key element in all GEMUs. The individual trials showed that admission to a GEMU has one or more favorable effects on the outcomes of interest, with two significant effects in the meta-analysis: less functional decline at discharge from the GEMU (RR=0.87, 95% confidence interval (CI)=0.77-0.99; P=.04) and a lower rate of institutionalization 1 year after discharge (RR=0.78, CI=0.66-0.92; P=.003). For the other outcomes in the meta-analysis, a GEMU did not induce significantly different outcomes than usual care. CONCLUSION: This meta-analysis shows a significant effect in favor of the GEMU group on functional decline at discharge and on institutionalization after 1 year. There is heterogeneity between the studies, poor quality of some randomized controlled trials, and shortage of information about CGA. Multidisciplinary CGA offered in a GEMU may add value to the care for frail older persons admitted to the hospital, but the limitations confirm the need for well-designed studies using explicit CGA and more-structured and -coherent assessment instruments such as the Minimum Data Set Resident Assessment Instrument. [less ▲]

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See detailLes deux laïcités
Jacquemain, Marc ULg

Learning material (2010)

Le document synthétise ce qui semble la ligne de fracture majeure au sein de la laïcité franco-belge : opposition entre une conception "républicaine" et une conception "libérale". Les deux peuvent se ... [more ▼]

Le document synthétise ce qui semble la ligne de fracture majeure au sein de la laïcité franco-belge : opposition entre une conception "républicaine" et une conception "libérale". Les deux peuvent se réclamer de la tradition laïque mais la première inclut une forme d'hostilité de principe à la religion qui est étrangère à la seconde. Le document tente de synthétiser les principales conséquences politiques de ces deux conceptions en passant en revue la neutralité des agents de l'Etat, la neutralité des citoyens et des élèves, ainsi que les discriminations indirectes et les accommodements raisonnables. Sur ces quatre points, les deux conceptions de la laïcité conduisent à des positions politiques différentes. Normativement, le document défend la primauté réelle, mais pas inconditionnelle, de la liberté d'expression. [less ▲]

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See detailThe net biome production of full crop rotations in Europe
Kutsch, W. L.; Aubinet, Marc ULg; Buchmann, N. et al

in Agriculture, Ecosystems & Environment (2010), 139

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See detail2-Point correlation function of nanostructured materials via the grey-tone correlation function of electron tomograms: A three-dimensional structural analysis of ordered mesoporous silica
Gommes, Cédric ULg; Friedrich, Heiner; De Jongh, Petra E et al

in Acta Materialia (2010), 58

Electron tomography is a unique technique for imaging the microstructure of materials with a nanometer resolution. The signal to noise ratio of electron tomograms is, however, often too low for a reliable ... [more ▼]

Electron tomography is a unique technique for imaging the microstructure of materials with a nanometer resolution. The signal to noise ratio of electron tomograms is, however, often too low for a reliable segmentation-based image analysis. We derive a general relation between the grey-tone correlation function of the tomograms and the 2-point correlation function of the morphology, which enables to analyze quantitatively the grey-tone correlation function with a morphological model of the material. The methodology is applied to SBA-15 ordered mesoporous silica. The three-dimensional grey-tone correlation function obtained from electron tomography is analyzed in terms of a hexagonal array of Gaussian independent pores. The model enables to relate the morphology obtained from the 2-point correlation function to macroscopic characterization data of the material, notably small-angle X-ray scattering and nitrogen adsorption. [less ▲]

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See detailHDA cycloadditions of 1-diethoxyphosphonyl-1,3-butadiene with nitroso heterodienophiles: a computational investigation
Monbaliu, Jean-Christophe ULg; Dive, Georges ULg; Marchand-Brynaert, Jacqueline et al

in Journal of Molecular Structure : Theochem (2010), 959

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See detailMathematical modelling of cell aggregates for bone tissue engineering using continuum methods
Geris, Liesbet ULg; Clarke, T.; Ashbourn, J.

in Middleton, J.; Jacobs, C.; Walker, B. (Eds.) et al 9th International symposium on Computer Methods in Biomechanics and Biomedical Engineering (2010)

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See detailMathémagie et au-delà
Rigo, Michel ULg

Learning material (2010)

Nous présentons ici 5 tours de magie ne nécessitant aucune habileté particulière de la part de l'apprenti magicien : des tours de cartes, des tours de divination et le célèbre tour du ``barman aveugle ... [more ▼]

Nous présentons ici 5 tours de magie ne nécessitant aucune habileté particulière de la part de l'apprenti magicien : des tours de cartes, des tours de divination et le célèbre tour du ``barman aveugle avec des gants de boxe''. Contrairement au magicien qui ne dévoile jamais ses secrets, ici, nous expliquons que ces tours reposent sur diverses propriétés et constructions mathématiques. Ces dernières débouchent sur de véritables questions de recherche actuelle en théorie des graphes ou en combinatoire des mots et même sur de possibles applications en robotique et automatisation ! Il y en aura donc pour tous les goûts... et tous les niveaux (suivant l'auditoire, l'exposé sera adapté au niveau des élèves de la 4ième à la 6ième secondaire, voire même aux étudiants universitaires). Ce texte présente donc un matériel qui dépassera souvent (et de loin) le ``spectacle''. [less ▲]

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See detailHigh Levels of 18F-FDG Uptake in Aortic Aneurysm Wall are Associated with High Wall Stress
Xu, Yun; Borghi, Alexandre; NCHIMI LONGANG, Alain ULg et al

in European Journal of Vascular and Endovascular Surgery (2010), 39

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See detailNéerlandais / Presse radio
Yans, Baudoin ULg; Engelen, Nicole ULg; Nachtergaele, Lutgarde

Book published by De Boeck Université (2010)

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See detailOperational multipartite entanglement classes for symmetric photonic qubit states
Kiesel, N.; Wieczorek, W.; Krins, Stéphanie ULg et al

Poster (2010)

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See detailThe umbilical cord matrix is a better source of mesenchymal stem cells (MSC) than the umbilical cord blood.
Zeddou, Mustapha ULg; Briquet, Alexandra ULg; Relic, Biserka ULg et al

in Cell Biology International (2010), 34(7), 693-701

Many studies have drawn attention to the emerging role of MSC (mesenchymal stem cells) as a promising population supporting new clinical concepts in cellular therapy. However, the sources from which these ... [more ▼]

Many studies have drawn attention to the emerging role of MSC (mesenchymal stem cells) as a promising population supporting new clinical concepts in cellular therapy. However, the sources from which these cells can be isolated are still under discussion. Whereas BM (bone marrow) is presented as the main source of MSC, despite the invasive procedure related to this source, the possibility of isolating sufficient numbers of these cells from UCB (umbilical cord blood) remains controversial. Here, we present the results of experiments aimed at isolating MSC from UCB, BM and UCM (umbilical cord matrix) using different methods of isolation and various culture media that summarize the main procedures and criteria reported in the literature. Whereas isolation of MSC were successful from BM (10:10) and (UCM) (8:8), only one cord blood sample (1:15) gave rise to MSC using various culture media [DMEM (Dulbecco's modified Eagle's medium) +5% platelet lysate, DMEM+10% FBS (fetal bovine serum), DMEM+10% human UCB serum, MSCGM] and different isolation methods [plastic adherence of total MNC (mononuclear cells), CD3+/CD19+/CD14+/CD38+-depleted MNC and CD133+- or LNGFR+-enriched MNC]. MSC from UCM and BM were able to differentiate into adipocytes, osteocytes and hepatocytes. The expansion potential was highest for MSC from UCM. The two cell populations had CD90+/CD73+/CD105+ phenotype with the additional expression of SSEA4 and LNGFR for BM MSC. These results clearly exclude UCB from the list of MSC sources for clinical use and propose instead UCM as a rich, non-invasive and abundant source of MSC. [less ▲]

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See detailLes nouveaux défis de l'enseignement du français langue étrangère en Europe
Defays, Jean-Marc ULg

in Dialogues et Cultures (2010), 56

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See detailIMA Commission on New Minerals, Nomenclature and Classification (CNMNC), Newsletter 3
Williams, Pete; Hatert, Frédéric ULg; Pasero, Marco et al

in Mineralogical Magazine (2010), 74

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