Controversy about the cardiovascular safety of sibutramine.
in Drug Safety : An International Journal of Medical Toxicology & Drug Experience (2010), 33(7), 615-8Detailed reference viewed: 48 (2 ULg)
Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup.
; ; et al
in Antimicrobial agents and chemotherapy (2010), 54(7), 3070-1Detailed reference viewed: 9 (0 ULg)
Effect of intravenous infusion of lidocaine on spontaneous recovery from cisatracurium-induced neuromuscular block: Preliminary results: 9AP4--3
HANS, Grégory ; ; et al
in European Journal of Anaesthesiology (2010), 27(47), 149Detailed reference viewed: 7 (2 ULg)
From Non-invasive Site Characterization to Site Amplification: Recent Advances in the Use of Ambient Vibration Measurements.
; ; Havenith, Hans-Balder
in Geotechnical, Geological and Earthquake Engineering : Earthquake Engineering in Europe (2010)Detailed reference viewed: 28 (0 ULg)
Semi-solid metallic alloys modeling for the simulation of thixoforming processes
Koeune, Roxane ; Ponthot, Jean-Philippe
in Vaz Jr., M.; de Souza Neto, E. A.; Munoz-Rojas, P. A. (Eds.) Computational Materials Modeling (2010)Detailed reference viewed: 47 (16 ULg)
Novel peptide inhibiting both TEM-1 beta-lactamase and penicillin-binding proteins.
; ; et al
in The FEBS journal (2010), 277(23), 4965-72
9G4H9, a catalytic antibody displaying beta-lactamase-like activity, has been developed by the anti-idiotypic approach using beta-lactamase as the first antigen. Thus 9G4H9 represents the 'internal image ... [more ▼]
9G4H9, a catalytic antibody displaying beta-lactamase-like activity, has been developed by the anti-idiotypic approach using beta-lactamase as the first antigen. Thus 9G4H9 represents the 'internal image' of beta-lactamase. We selected a cyclic peptide anchored to a bacteriophage M13 library using 9G4H9 as the target. Pep90 is a cyclic heptapeptide enclosed between two cysteine residues. We showed that Pep90 could inhibit both TEM-1 beta-lactamase (K(i) = 333 mum) and several penicillin-binding proteins (IC(5)(0) values ranging from 6-62 mum). We determined that the tryptophan residue of Pep90 is of crucial importance for its inhibitory activity. Using Pep90 as a scaffold, we generated a new class of peptidomimetics that retained inhibitory activity towards TEM-1 beta-lactamase. [less ▲]Detailed reference viewed: 23 (0 ULg)
IRF6 Screening of Syndromic and a priori Non-Syndromic Cleft Lip and Palate Patients: Identification of a New Type of Minor VWS Sign.
; ; et al
in Molecular Syndromology (2010), 1(2), 67-74
Van der Woude syndrome (VWS), caused by dominant IRF6 mutation, is the most common cleft syndrome. In 15% of the patients, lip pits are absent and the phenotype mimics isolated clefts. Therefore, we ... [more ▼]
Van der Woude syndrome (VWS), caused by dominant IRF6 mutation, is the most common cleft syndrome. In 15% of the patients, lip pits are absent and the phenotype mimics isolated clefts. Therefore, we hypothesized that some of the families classified as having non-syndromic inherited cleft lip and palate could have an IRF6 mutation. We screened in total 170 patients with cleft lip with or without cleft palate (CL/P): 75 were syndromic and 95 were a priori part of multiplex non-syndromic families. A mutation was identified in 62.7 and 3.3% of the patients, respectively. In one of the 95 a priori non-syndromic families with an autosomal dominant inheritance (family B), new insights into the family history revealed the presence, at birth, of lower lip pits in two members and the diagnosis was revised as VWS. A novel lower lip sign was observed in one individual in this family. Interestingly, a similar lower lip sign was also observed in one individual from a 2nd family (family A). This consists of 2 nodules below the lower lip on the external side. In a 3rd multiplex family (family C), a de novo mutation was identified in an a priori non-syndromic CL/P patient. Re-examination after mutation screening revealed the presence of a tiny pit-looking lesion on the inner side of the lower lip leading to a revised diagnosis of VWS. On the basis of this data, we conclude that IRF6 should be screened when any doubt rises about the normality of the lower lip and also if a non-syndromic cleft lip patient (with or without cleft palate) has a family history suggestive of autosomal dominant inheritance. [less ▲]Detailed reference viewed: 27 (1 ULg)
Pieds et empreintes de pieds dans les cultes isiaques. Pour une meilleure compréhension des documents hispaniques
in Melanges de la Casa de Velazquez (2010), 40(2), 137-155
L’étude des cultes isiaques dans la péninsule Ibérique donne à connaître une série de documents qui représentent un pied sous sa forme réelle ou gravé sur des stèles votives. Se pose alors la question de ... [more ▼]
L’étude des cultes isiaques dans la péninsule Ibérique donne à connaître une série de documents qui représentent un pied sous sa forme réelle ou gravé sur des stèles votives. Se pose alors la question de l’origine de ce symbole. Apparenté aux divinités égyptiennes, il est synonyme de richesse et d’abondance dans la religion pharaonique. À partir de la vallée du Nil, les deux modèles se sont diffusés dans le monde méditerranéen et ils ont atteint l’Hispanie au IIe siècle en passant sans doute par le continent africain. Sans aucune référence dans la littérature antique, l’enquête menée autour de ces représentations et de leurs différentes déclinaisons n’autorise pas à leur attribuer une seule signification. Les pieds de Sérapis comme les stèles dédiées à Isis incarnent le plus souvent l’épiphanie divine, mais ils peuvent également être considérés comme de simples témoignages de dévotion. Lorsque les empreintes de pieds correspondent à celles de la déesse et que les stèles sont situées devant l’entrée du temple, elles pourraient faire référence à un rituel d’accueil. [less ▲]Detailed reference viewed: 33 (4 ULg)
Strategies pour eviter l'inertie et la non-observance dans les essais cliniques.
Jandrain, Bernard ; Ernest, Philippe ; Radermecker, Régis et al
in Revue Médicale de Liège (2010), 65(5-6), 246-9
Randomised controlled trials play a key role in evidence-based medicine as far as the assessment of both efficacy and safety of drugs is concerned. Various strategies are used to avoid physician's inertia ... [more ▼]
Randomised controlled trials play a key role in evidence-based medicine as far as the assessment of both efficacy and safety of drugs is concerned. Various strategies are used to avoid physician's inertia and to combat patient's non compliance, two pitfalls that may hinder the demonstration of the therapeutic efficacy of the drug. Clinical inertia may be limited by titration, forced or optional, driven by therapeutic targets, or by the use, if necessary, of rescue medications. Compliance may be verified by "pill count". This simple technique allows to exclude non compliant patients when they are detected during the placebo run-in period before randomisation or not to take into account patients with poor compliance in the final evaluation by using a statistical analysis restricted to individuals who have strictly adhered to the study protocol ("per protocol analysis"). Self-monitoring and patient's empowerment in the treatment also contribute to improve drug compliance. Clinicians may take advantage of these approaches derived from clinical trials to improve their daily practice. [less ▲]Detailed reference viewed: 252 (14 ULg)
Effect of macronutrient ratio of the pre-starter diet on broiler performance and intermediary metabolism.
; Everaert, Nadia ; et al
in Journal of Animal Physiology & Animal Nutrition (2010), 94(3), 375-84
The aim of this study was to investigate the influence of isoenergetic substitution between the three energy delivering macronutrients in pre-starter diets on performance and intermediary nutrient ... [more ▼]
The aim of this study was to investigate the influence of isoenergetic substitution between the three energy delivering macronutrients in pre-starter diets on performance and intermediary nutrient metabolism in broiler chickens. From hatch until 5 days of age, 600 chicks, collected during peak of hatch, were fed one of the three experimental pre-starter diets with isoenergetic (13 MJ metabolisable energy/kg) substitutions between fat (43 vs. 108 g/kg), protein (126 vs. 240 g/kg) and carbohydrates (391 vs. 510 g/kg). After 5 days, commercial grower and finisher diets were provided. Pre-starter composition influenced body weight until slaughter age, although not statistically verifiable. Broilers fed the low protein (LP) pre-starter had the lowest body weight in relation to chickens on the low carbohydrate or low fat pre-starter diet. After hatch, chicks on the LP pre-starter diet were able to use the residual yolk sac more rapidly to fulfil their protein requirement, which is reflected in small intestine and liver development. Also, plasma metabolite levels were influenced mostly by the LP pre-starter, indicating that the main focus for the requirements of newly hatched chicks should be on proteins. Furthermore, optimal nutrition during the first day's post-hatch should take into account the contribution of the yolk. [less ▲]Detailed reference viewed: 24 (2 ULg)
À l'Hôtel des Étrangers, repaire d'une bohème zutique
in Brissette, Pascal; Glinoer, Anthony (Eds.) Bohème sans frontière. Production et internationalisation d'une posture. (2010)Detailed reference viewed: 83 (8 ULg)
Didaktisches Begleitmaterial zur Inszenierung "Hase und Igel" von rosenfisch figurenspiel
Learning material (2010)Detailed reference viewed: 16 (0 ULg)
Experimental investigation of the effect of flip bucket splitters on plunge pool geometry
Erpicum, Sébastien ; Archambeau, Pierre ; Dewals, Benjamin et al
in RWTH - IWW (Ed.) Mitteilungen - 15. Deutsches Talsperrensymposium - Talsperren im Wandel (2010)
Flip buckets are common hydraulic structures aiming at deflecting high velocity flows to a free jet trajectory. Systematic experimental tests have been performed to assess the influence on energy ... [more ▼]
Flip buckets are common hydraulic structures aiming at deflecting high velocity flows to a free jet trajectory. Systematic experimental tests have been performed to assess the influence on energy dissipation and the plunge pool geometry of varied repartitions of splitters along the flip bucket width. In particular, it is shown that some configurations can create more erosion than a continuous channel without flip bucket. [less ▲]Detailed reference viewed: 37 (5 ULg)
Etude de la filière industrielle des énergirs renouvelables
; Andre, Philippe ; et al
Rapport final du projet Firewal2, réalisé en collaboration avec l'asbl Energy Factor 4Detailed reference viewed: 54 (12 ULg)
First man in the eastern Finland : an Early Mesolithic inland site with a red-ochre grave in Joensuu Rahakangas
; ; et al
Poster (2010)Detailed reference viewed: 65 (0 ULg)
A new type of cubic-stacked layer structure in anthoinite, AlWO3(OH3)
; ; et al
in American Mineralogist (2010), 95Detailed reference viewed: 11 (0 ULg)
La grippe féline ou l'infection du chat par les virus influenza
Thiry, Etienne ;
in Point Vétérinaire (2010), 41(64-68),Detailed reference viewed: 39 (0 ULg)
Revision and validation of the Family Apperception Test: some psychometric properties.
; Stievenart, Marie ; et al
in The Family Journal (2010), 18(3),
The Family Apperception Test (FAT) is a projective assessment procedure based on the family system theory. FAT allows the subjects’ affects and feelings about their family to be assessed. The original ... [more ▼]
The Family Apperception Test (FAT) is a projective assessment procedure based on the family system theory. FAT allows the subjects’ affects and feelings about their family to be assessed. The original version and its French translation removed some of the conceptual and psychometric limitations of previous projective tests and family assessment procedures but several questions remained. The current study proposes several modifications to the conceptual background, administration, coding procedure, and standardization of the FAT, which considerably improve its psychometric properties. Data were collected on 168 typical and clinical children in the French-speaking part of Belgium. The results provide significant evidence for inter- and intra-assessor reliability; the factorial analysis and the internal consistency of the revised version were good; the FAT enabled us to discriminate between typical children and those in the clinical sample. The discussion focuses on the interest and limits of the quantitative coding procedure, based on several categories conceptualized as risk versus protective factors. The FAT is characterized by a complementary approach—both quantitative and qualitative—to the children and their families. [less ▲]Detailed reference viewed: 17 (0 ULg)