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See detailThe impact of concomitant rhinitis on asthma-related quality of life and asthma control.
Vandenplas, O.; Dramaix, M.; Joos, G. et al

in Allergy (2010)

To cite this article: Vandenplas O, Dramaix M, Joos G, Louis R, Michils A, Verleden G, Vincken W, Vints A-M, Herbots E, Bachert C. The impact of concomitant rhinitis on asthma-related quality of life and ... [more ▼]

To cite this article: Vandenplas O, Dramaix M, Joos G, Louis R, Michils A, Verleden G, Vincken W, Vints A-M, Herbots E, Bachert C. The impact of concomitant rhinitis on asthma-related quality of life and asthma control. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02365.x. Abstract Background: Characterizing the interactions between the upper and lower airways is important for the management of asthma. This study aimed at assessing the specific impact of concomitant rhinitis on asthma-related quality of life (QOL) and asthma control. Methods: A cross-sectional, observational survey was conducted among 1173 patients with asthma (aged 12-45) recruited by general practitioners and chest physicians. AR was defined by self-reported rhinitis symptoms and previously documented sensitization to inhalant allergens. The primary outcomes were (1) asthma control assessed by the Asthma Control Questionnaire (ACQ) and (2) asthma-specific QOL evaluated through the Mini Asthma Quality of Life Questionnaire (mAQLQ). Results: AR was present in 73.9% of the population with asthma and nonallergic rhinitis (NAR) in 13.6%. AR and NAR were associated with an increased risk of uncontrolled asthma (i.e. ACQ score > 1.5) with adjusted odds ratios (OR) of 2.00 (95% confidence interval [CI]: 1.35-2.97) and 1.77 (95%CI: 1.09-2.89), respectively. Multivariate linear regression analysis showed that AR and NAR had a modest, although significant, negative impact on the global mAQLQ score (beta coefficient: -0.293, standard error [SE]: 0.063 and beta coefficient: -0.221, SE: 0.080, P < 0.001, respectively), even after adjustment for the level of asthma control and demographic characteristics. Conclusion: This survey provides direct evidence that AR and NAR are associated with an incremental adverse impact on the disease-specific QOL of patients with asthma and the level of asthma control. Further investigations are required to determine whether appropriate treatment of rhinitis would efficiently reduce asthma morbidity. [less ▲]

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See detailDosage par GC/QQQ de huit pesticides organochlorés dans le sérum
Dubois, Nathalie ULg; Elbaz, A.; Charlier, Corinne ULg

in Acta Clinica Belgica (2010), 65(1), 58-64

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See detailPieds et empreintes de pieds dans les cultes isiaques. Pour une meilleure compréhension des documents hispaniques
Puccio, Laetizia ULg

in Melanges de la Casa de Velazquez (2010), 40(2), 137-155

L’étude des cultes isiaques dans la péninsule Ibérique donne à connaître une série de documents qui représentent un pied sous sa forme réelle ou gravé sur des stèles votives. Se pose alors la question de ... [more ▼]

L’étude des cultes isiaques dans la péninsule Ibérique donne à connaître une série de documents qui représentent un pied sous sa forme réelle ou gravé sur des stèles votives. Se pose alors la question de l’origine de ce symbole. Apparenté aux divinités égyptiennes, il est synonyme de richesse et d’abondance dans la religion pharaonique. À partir de la vallée du Nil, les deux modèles se sont diffusés dans le monde méditerranéen et ils ont atteint l’Hispanie au IIe siècle en passant sans doute par le continent africain. Sans aucune référence dans la littérature antique, l’enquête menée autour de ces représentations et de leurs différentes déclinaisons n’autorise pas à leur attribuer une seule signification. Les pieds de Sérapis comme les stèles dédiées à Isis incarnent le plus souvent l’épiphanie divine, mais ils peuvent également être considérés comme de simples témoignages de dévotion. Lorsque les empreintes de pieds correspondent à celles de la déesse et que les stèles sont situées devant l’entrée du temple, elles pourraient faire référence à un rituel d’accueil. [less ▲]

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See detailFormulation des bétons
Courard, Luc ULg

Learning material (2010)

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See detailDiagenèse osseuse et genèse de nodules phosphatés, associés aux sédiments fluvio-lacustres de sites à hominidés miocène (Kenya)
DERICQUEBOURG, P.; PERSON, A.; SEGALEN, L. et al

Poster (2010)

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See detailFrom Non-invasive Site Characterization to Site Amplification: Recent Advances in the Use of Ambient Vibration Measurements.
Bard, P-Y; et al.; Havenith, Hans-Balder ULg

in Geotechnical, Geological and Earthquake Engineering : Earthquake Engineering in Europe (2010)

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See detailSketSha
Leclercq, Pierre ULg; Delfosse, Vincent ULg; Schroyen, Géraldine et al

Software (2010)

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See detailLocal Cooperativity in an Amyloidogenic State of Human Lysozyme Observed at Atomic Resolution.
Dhulesia, A.; Cremades, N.; Kumita, J. R. et al

in Journal of the American Chemical Society (2010)

The partial unfolding of human lysozyme underlies its conversion from the soluble state into amyloid fibrils observed in a fatal hereditary form of systemic amyloidosis. To understand the molecular ... [more ▼]

The partial unfolding of human lysozyme underlies its conversion from the soluble state into amyloid fibrils observed in a fatal hereditary form of systemic amyloidosis. To understand the molecular origins of the disease, it is critical to characterize the structural and physicochemical properties of the amyloidogenic states of the protein. Here we provide a high-resolution view of the unfolding process at low pH for three different lysozyme variants, the wild-type protein and the mutants I56T and I59T, which show variable stabilities and propensities to aggregate in vitro. Using a range of biophysical techniques that includes differential scanning calorimetry and nuclear magnetic resonance spectroscopy, we demonstrate that thermal unfolding under amyloidogenic solution conditions involves a cooperative loss of native tertiary structure, followed by progressive unfolding of a compact, molten globule-like denatured state ensemble as the temperature is increased. The width of the temperature window over which the denatured ensemble progressively unfolds correlates with the relative amyloidogenicity and stability of these variants, and the region of lysozyme that unfolds first maps to that which forms the core of the amyloid fibrils formed under similar conditions. Together, these results present a coherent picture at atomic resolution of the initial events underlying amyloid formation by a globular protein. [less ▲]

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See detailTravaux pratiques en Histologie Humaine, Quadrimestre 4, 5 et 6
Defaweux, Valérie ULg; Mélot, France ULg; Florquin, Sandra ULg et al

Learning material (2010)

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See detailWhat’s in a name: Social vulnerabilities and the refugee controversy in the wake of Hurricane Katrina
Gemenne, François ULg

in Afifi, Tamer; Jäger, Jill (Eds.) Environment, Forced Migration and Social Vulnerability (2010)

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See detailComponent-resolved diagnosis in peanut and hazelnut allergy.
Gadisseur, Romy ULg; Chapelle, Jean-Paul ULg; Cavalier, Etienne ULg et al

in Allergy (2010), 65(Suppl.92), 106

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See detailChronology of the Middle to Upper Palaeolithic Transition in Belgium
Pirson, S.; Haesaerts, P.; Semal, P. et al

Conference (2010)

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See detailComment le texte touche le corps
Vandeninden, Elise ULg

in Etudes Littéraires (2010), (été), 80-88

Le corps est la plupart du temps absent des théories de la réception : on évoque peu sa matérialité (le corps « objet ») ; encore moins son sentir (le corps « sujet ») emprunt de pensée. A cette ... [more ▼]

Le corps est la plupart du temps absent des théories de la réception : on évoque peu sa matérialité (le corps « objet ») ; encore moins son sentir (le corps « sujet ») emprunt de pensée. A cette résistance, correspond sans doute le trouble qu’il sème sur notre appréhension de la lecture comme activité herméneutique. Mais se priver d’interroger le corps revient à manquer la spécificité du rapport entre écrivain et lecteur. Comment se rencontrent-ils dans le texte ? De quelle façon leurs corps se touchent l’un l’autre ? Telles sont les questions que pose leur « hétéro-affection » à partir de laquelle nous proposerons d’envisager la littérature comme modèle de notre « être en commun ». [less ▲]

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See detailOceanic CO2 sink: the contribution of the marine cryosphere
Delille, Bruno ULg; Vancoppenolle, M.; Tilbrook, B. et al

Conference (2010)

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See detailCombined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female Beagle dogs
Noël, Stéphanie; Cambier, Carole; Baert, Kris et al

in Veterinary Journal (2010)

This study investigated the differences in pharmacokinetic, urodynamic and haemodynamic parameters in female Beagle dogs in which blood sampling and urethral pressure profiles were performed over 24 h ... [more ▼]

This study investigated the differences in pharmacokinetic, urodynamic and haemodynamic parameters in female Beagle dogs in which blood sampling and urethral pressure profiles were performed over 24 h periods, after single or three times daily (T0-T6h-T12h) administration of phenylpropanolamine (PPA). Maximal concentration (Cmax) was reached 2 h after PPA administration (Tmax). The half-life lasted 4 h and, because of bioaccumulation, three times daily administration induced an increase in Cmax. Compared to the control group, a significant increase in urethral resistance was observed at Tmax after 1 week of once daily administrations. After one week of administering PPA every 6 h during the daytime, but not during the night, and despite higher plasma concentrations, the urethral resistance did not increase at any time, compared to the control group. The increase in mean arterial pressure values was compensated by a decreased heart rate. The clinical efficacy of the temporary increase in urethral resistance following single daily administration of PPA in dogs suffering from urethral sphincter mechanism incompetence (USMI) needs to be further investigated in a randomised clinical trial. [less ▲]

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See detailVersican overexpression in human breast cancer lesions: Known and new isoforms for stromal tumor targeting.
Kischel, Philippe ULg; Waltregny, David ULg; Dumont, Bruno ULg et al

in International Journal of Cancer = Journal International du Cancer (2010), 126(3), 640-50

Proteoglycans play a key role in cancer development and progression by participating in the constitution of a specific fertile tumor microenvironment. As they are largely overexpressed in the malignant ... [more ▼]

Proteoglycans play a key role in cancer development and progression by participating in the constitution of a specific fertile tumor microenvironment. As they are largely overexpressed in the malignant stroma, proteoglycans provide a reservoir of potential new targets for anticancer therapies, because they can serve to convey toxic payloads in the close proximity of cancer cells and subsequently destroy them. In this context, versican, a proteoglycan largely overexpressed in several solid cancers, bears the potential to be such an ideal target. As 4 main versican isoforms have been characterized, we sought to determine which isoform could represent the best target in human breast cancer. We used a series of 10 primary breast cancer lesions that were characterized as overexpressing the versican protein, when compared with matched normal breast tissues, using shotgun mass spectrometry and immunohistochemistry experiments. Quantitative polymerase chain reaction and western-blotting experiments were used to evaluate versican isoform expression in breast cancer/normal tissue pairs for which ARN quality was excellent. All known isoforms were significantly overexpressed in the malignant lesions, both at the mRNA and at the protein levels. In the course of this study, we also identified and cloned a new alternatively spliced versican isoform, referred to as V4, which was also found to be upregulated in human breast cancer. This study provides for the first time a comprehensive mRNA and protein analysis of versican isoforms expression in human breast tissues, and offers insights into which therapeutic strategy would be best suited to target versican in human breast cancer lesions. [less ▲]

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See detailFibromyalgia and related conditions: Electromyogram profile during isometric muscle contraction
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Dupont, Catherine ULg et al

in Joint Bone Spine (2010), 77

Objectives: To evaluate electromyogram (EMG) profiles in patients with three related conditions: fibromyalgia, chronic fatigue syndrome, and depression. Methods: We studied 44 healthy volunteers, 22 ... [more ▼]

Objectives: To evaluate electromyogram (EMG) profiles in patients with three related conditions: fibromyalgia, chronic fatigue syndrome, and depression. Methods: We studied 44 healthy volunteers, 22 patients with fibromyalgia, 11 patients with chronic fatigue syndrome, and 10 patients admitted for depression. The trapezius electromyogram was recorded during maximally sustained, bilateral, 90◦ abduction of the shoulders. EMG signal frequency and amplitude were measured throughout the test. Results: In the fibromyalgia group, isometric contraction duration was significantly shorter than in the other two patient groups (P < 0.001) and the EMG frequency and amplitude pattern indicated premature discontinuation of the muscle contraction. Findings in the chronic fatigue patients were similar to those in the healthy controls. The patients with depression had a distinctive EMG profile characterized by excessive initial motor-unit recruitment with a shift in the frequency spectrum. Conclusions: Fibromyalgia was associated with a specific EMG pattern indicating premature discontinuation of the muscle contraction. Therefore, maximal voluntary muscle contraction tests may be of limited value for assessing function in fibromyalgia patients. Chronic fatigue syndrome patients had similar EMG findings to those in the healthy controls. The EMG alterations in the patients with depression were consistent with manifestations of psychomotor retardation. [less ▲]

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See detail"Le droit des biens : une évolution indispensable sans révolution inutile"
Lecocq, Pascale ULg; Vanbrabant, Bernard ULg

in L'avenir de la recherche, Réflexions à l'occasion des leçons inaugurales 2010 (2010)

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See detailLes méthodes de travail des historiens en Islam
Bauden, Frédéric ULg

Book published by Istituto per l'Oriente C. A. Nallino (2010)

Detailed reference viewed: 62 (4 ULg)