References of "2010"
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See detailAladdin nulling instrument
Barillot, Marc; Coudé Du Foresto, Vincent; Surdej, Jean ULg et al

in Spinoglio, L.; Epchtein, N. (Eds.) 3rd ARENA Conference: An Astronomical Observatory at CONCORDIA (Dome C, Antarctica) (2010)

The ALADDIN project aims at detecting warm dust populations around nearby main sequence stars. In order to achieve the significantly improved sensitivity with respect to existing instruments, the ... [more ▼]

The ALADDIN project aims at detecting warm dust populations around nearby main sequence stars. In order to achieve the significantly improved sensitivity with respect to existing instruments, the architecture of the system is focused and optimised for the mission: ALADDIN implements the nulling interferometry technique at the focal plane of a 2-telescope interferometer mounted on a rotating structural beam. Concerning the beam combining nulling instrument, the ALADDIN design is inherited from a Definition Study of the VLTI/GENIE instrument. In this paper, we demonstrate how the ALADDIN instrument preliminary definition can be made simpler and more representative of a space instrument than GENIE thanks to both the outstanding atmospheric properties of Dome C and the dedicated architecture of the system. Finally, we discuss the compatibility of the instrument with the Antarctic environment and constraints, and underline the experimental and industrial know-how learnt from the MAII and PERSEE nulling breadboards in which our Team is also involved. [less ▲]

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See detailStructure and properties of a complex of alpha-synuclein and a single-domain camelid antibody.
De Genst, Erwin J; Guilliams, Tim; Wellens, Joke et al

in Journal of Molecular Biology (2010), 402(2), 326-43

The aggregation of the intrinsically disordered protein alpha-synuclein to form fibrillar amyloid structures is intimately associated with a variety of neurological disorders, most notably Parkinson's ... [more ▼]

The aggregation of the intrinsically disordered protein alpha-synuclein to form fibrillar amyloid structures is intimately associated with a variety of neurological disorders, most notably Parkinson's disease. The molecular mechanism of alpha-synuclein aggregation and toxicity is not yet understood in any detail, not least because of the paucity of structural probes through which to study the behavior of such a disordered system. Here, we describe an investigation involving a single-domain camelid antibody, NbSyn2, selected by phage display techniques to bind to alpha-synuclein, including the exploration of its effects on the in vitro aggregation of the protein under a variety of conditions. We show using isothermal calorimetric methods that NbSyn2 binds specifically to monomeric alpha-synuclein with nanomolar affinity and by means of NMR spectroscopy that it interacts with the four C-terminal residues of the protein. This latter finding is confirmed by the determination of a crystal structure of NbSyn2 bound to a peptide encompassing the nine C-terminal residues of alpha-synuclein. The NbSyn2:alpha-synuclein interaction is mediated mainly by side-chain interactions while water molecules cross-link the main-chain atoms of alpha-synuclein to atoms of NbSyn2, a feature we believe could be important in intrinsically disordered protein interactions more generally. The aggregation behavior of alpha-synuclein at physiological pH, including the morphology of the resulting fibrillar structures, is remarkably unaffected by the presence of NbSyn2 and indeed we show that NbSyn2 binds strongly to the aggregated as well as to the soluble forms of alpha-synuclein. These results give strong support to the conjecture that the C-terminal region of the protein is not directly involved in the mechanism of aggregation and suggest that binding of NbSyn2 could be a useful probe for the identification of alpha-synuclein aggregation in vitro and possibly in vivo. [less ▲]

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See detailCompte-rendu de l'ouvrage de Jens SCHNEIDER, Auf der Suche nach dem verlorenen Reich
Close, Florence ULg

in Francia-Recensio (2010), (3),

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See detailMagnetocaloric effect in nano- and polycrystalline manganites La0.5Ca0.5MnO3
Pekala, Marek; Drozd, Vadym; Fagnard, Jean-François ULg et al

in Journal of Alloys & Compounds (2010), 507

Structure, magnetic and magnetocaloric properties of poly- and nanocrystalline La0.5Ca0.5MnO3 manganites prepared by the citrate sol–gel method are studied in a broad temperature range. The Arrott plots ... [more ▼]

Structure, magnetic and magnetocaloric properties of poly- and nanocrystalline La0.5Ca0.5MnO3 manganites prepared by the citrate sol–gel method are studied in a broad temperature range. The Arrott plots show that the phase transition is of the second order. The cooling efficiency of 93–97 J/kg is found for the poly- and nanocrystalline samples. The relatively weaker magnetocaloric effect in nanocrystalline La0.5Ca0.5MnO3 is spread over temperature range almost three times broader than for the polycrystalline one. Charge ordering effects decay in manganites with grain sizes below 150 nm. [less ▲]

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See detailInfluence of cysteamine on in vitro maturation, in vitro and in vivo fertilization of equine oocytes
Deleuze, Stefan ULg; Dubois, Clotilde; Caillaud, Maud et al

in Reprod Domest Anim (2010), 45(1), 1-7

Contents The effect of cysteamine on in vitro nuclear and cytoplasmic maturation of equine oocytes collected by transvaginal ultrasound guided follicular aspiration was assessed. Oocytes were matured in ... [more ▼]

Contents The effect of cysteamine on in vitro nuclear and cytoplasmic maturation of equine oocytes collected by transvaginal ultrasound guided follicular aspiration was assessed. Oocytes were matured in vitro with (cysteamine group) or without (control group) cysteamine. The nuclear stage after DNA Hoechst staining, penetration rates after two different in vitro fertilization (IVF) techniques (IVF media with ionophore and Hepes buffer with heparin) and the embryo yield following oocyte intra-oviductal transfer were used as a criterion for assessing nuclear and cytoplasmic maturation, respectively. Contrary to the data described in other domestic species, there was no effect of cysteamine on in vitro nuclear maturation, IVF or in vivo embryonic development under our conditions. Ovum pick up yields (52%) and maturation rates (control group: 47% and cysteamine group: 55%) were similar to those previously reported. From 57 oocytes transferred to the oviduct in each group, the number of embryos collected was 10 (17%) in the control group and five in the cysteamine group (9%). Those two percentages were not statistically different (p > 0.05). No effect of IVF technique was seen on the success rate (6%) in each group. [less ▲]

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See detailSémiotique de l'image scientifique
Dondero, Maria Giulia ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (2010), 1

This work aims to establish the state of the art in the area of semiotic research on the role of the image in scientific discourse, a topic which has recently given rise to renewed interest in Francophone ... [more ▼]

This work aims to establish the state of the art in the area of semiotic research on the role of the image in scientific discourse, a topic which has recently given rise to renewed interest in Francophone semiotics. The questions concerning the scientific image open up new perspectives for semiotic studies. The research revisits issues that are fundamental to all semiotic approaches (the concept of reference and the genesis of the plane of expression in visual texts, for example) and also leads to encounters between different semiotic traditions, such as those of Ch. S. Peirce, the Paris School, and the Groupe µ. Four questions appear crucial to the future of semiotics and reappear throughout the article : 1. the relation between the image and the techniques that produce it, which leads to considerations on the status of scientific reference ; 2. the relation between the image and mathematization, which allows us to deal with the question of the diagram and diagrammatic reasoning ; 3. the relation between “the image in the process of being made” in the laboratory and the image selected by scientific literature (“the finished image”) and especially the relation between a research article for specialized journals and works of popularization ; 4. finally, the consideration of the different discursive genres of scientific production leads us to reflections on the relation between popularization and the domain of art. [less ▲]

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See detailLes significations du style graphique: Mon fiston d’Olivier Schrauwen et Faire semblant, c’est mentir de Dominique Goblet
Meesters, Gert ULg

in Textyles : Revue des Lettres Belges de Langue Française (2010), (36-37), 215-233

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See detailIntérêt du dosage des sulfamidés hypoglycémiants: de la vérification de la compliance au diagnostic différentiel des hyperinsulinismes
Denooz, Raphael ULg; Charlier, Corinne ULg

in Revue Médicale de Liège (2010), 65(9), 493-497

Plus de cinquante ans après leur mise sur le marché, les sulfamidés hypoglycémiants font toujours partie du traitement de base du diabète non insulinodépendant. A côté de leurs remarquables propriétés ... [more ▼]

Plus de cinquante ans après leur mise sur le marché, les sulfamidés hypoglycémiants font toujours partie du traitement de base du diabète non insulinodépendant. A côté de leurs remarquables propriétés pharmacologiques, ces produits ont, à différentes reprises, été tenus responsables d’hypoglycémies sévères survenant de manière inexpliquée chez des sujets non diabétiques. Ce type d’hypoglycémie, qualifiée de factice, est notamment fréquemment retrouvée dans le syndrome de Munchausen, trouble psychiatrique poussant le malade à mimer une pathologie. Cette hypoglycémie est associée à un hyperinsulinisme endogène simulant une pathologie endocrine très rare, l’insulinome. Nous souhaitons faire connaître aux Cliniciens l’intérêt de la recherche et du dosage sanguin des sulfamidés hypoglycémiants dans le cadre du diagnostic différentiel des hyperinsulinismes. La mise en évidence d’une hypoglycémie induite par ces médicaments constitue un élément intéressant pour orienter le diagnostic et éventuellement éviter une pancréatectomie en cas de forte suspicion d’insulinome. La méthode analytique développée au laboratoire s’appuie sur la chromatographie liquide ultra performante couplée à la spectrométrie de masse tandem (UPLC -MS -MS ). Par cette technique, on peut mettre en évidence dans le sang une dizaine de sulfonylurées et le répaglinide. Elle constituera à l’avenir une méthode de choix face à toute suspicion de mésusage des sulfonylurées. [less ▲]

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See detailIncreased mitosis in the bleached gastrodermis of the sea anemone A. pallida
Fransolet, David ULg; Roberty, Stéphane ULg; Plumier, Jean-Christophe ULg

Poster (2010)

Today, coral bleaching represents a major concern for marine biologists, especially considering the upsurge of this phenomenon possibly linked to climate change. Bleached corals, deprived of most of their ... [more ▼]

Today, coral bleaching represents a major concern for marine biologists, especially considering the upsurge of this phenomenon possibly linked to climate change. Bleached corals, deprived of most of their energy incomes, may show a partial or total mortality, which ultimately lead to shifts in reef communities. Studies focusing on cellular bleaching mechanisms have shown different ways by which algae may be expelled from gastrodermal host cells. Among those mechanisms, major emphasis has been put on host cell death, most probably due to both apoptosis and necrosis. Recovering gastrodermis is then expected to undergo regeneration process in order to be reinfected by new algae. We describe here this regeneration process in the bleached sea anemone model A. pallida. [less ▲]

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See detailModal testing using nonlinear normal modes: experimental demonstration
Peeters, Maxime ULg; Kerschen, Gaëtan ULg; Golinval, Jean-Claude ULg

in Proceedings of the International Conference on Noise and Vibration Engineering (2010)

Modal testing and analysis is well-established for linear vibrating structures. While the common practice is to assume linear behavior, nonlinearity is a frequent occurrence in engineering applications ... [more ▼]

Modal testing and analysis is well-established for linear vibrating structures. While the common practice is to assume linear behavior, nonlinearity is a frequent occurrence in engineering applications and can drastically alter the behavior of mechanical systems. In this paper, an attempt is made to extend experimental modal analysis methodology to a practical nonlinear analog. In this context, nonlinear normal modes (NNMs) offer a solid theoretical and mathematical tool for interpreting a wide class of nonlinear dynamical phenomena, yet they have a clear and simple conceptual relation to the classical linear normal modes. Based on a nonlinear extension of phase resonance testing (also called force appropriation), the proposed methodology excites the structure to isolate one single NNM during the experiments. Thanks to the invariance principle, the energy dependence of that nonlinear mode (i.e., the NNM modal curves and their frequencies of oscillation) can be extracted from the resulting free decay response using time-frequency analysis. The proposed method is demonstrated using an experimental cantilever beam with a geometrical nonlinearity. [less ▲]

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See detailGenome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.
Anttila, Verneri; Stefansson, Hreinn; Kallela, Mikko et al

in Nature Genetics (2010), 42(10), 869-73

Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular ... [more ▼]

Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular markers for migraine have been convincingly established. We identified the minor allele of rs1835740 on chromosome 8q22.1 to be associated with migraine (P = 5.38 x 10, odds ratio = 1.23, 95% CI 1.150-1.324) in a genome-wide association study of 2,731 migraine cases ascertained from three European headache clinics and 10,747 population-matched controls. The association was replicated in 3,202 cases and 40,062 controls for an overall meta-analysis P value of 1.69 x 10(1)(1) (odds ratio = 1.18, 95% CI 1.127-1.244). rs1835740 is located between MTDH (astrocyte elevated gene 1, also known as AEG-1) and PGCP (encoding plasma glutamate carboxypeptidase). In an expression quantitative trait study in lymphoblastoid cell lines, transcript levels of the MTDH were found to have a significant correlation to rs1835740 (P = 3.96 x 10, permuted threshold for genome-wide significance 7.7 x 10. To our knowledge, our data establish rs1835740 as the first genetic risk factor for migraine. [less ▲]

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See detailNéerlandais / Presse radio
Yans, Baudoin ULg; Engelen, Nicole ULg; Nachtergaele, Lutgarde

Book published by De Boeck Université (2010)

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See detailThe effectiveness of inpatient geriatric evaluation and management units: a systematic review and meta-analysis.
Van Craen, Katleen; Braes, Tom; Wellens, Nathalie et al

in Journal of the American Geriatrics Society (2010), 58(1), 83-92

OBJECTIVES: To examine how geriatric evaluation and management units (GEMUs) are organized and to examine the effectiveness of admission on a GEMU. DESIGN: Systematic review and meta-analysis based on ... [more ▼]

OBJECTIVES: To examine how geriatric evaluation and management units (GEMUs) are organized and to examine the effectiveness of admission on a GEMU. DESIGN: Systematic review and meta-analysis based on literature search of multiple databases and the references lists of all identified articles and by contacting authors. SETTING: GEMUs. PARTICIPANTS: Elderly people admitted to a GEMU. MEASUREMENTS: Quality of the studies was assessed on 10 criteria. The outcome parameters were mortality, institutionalization, functional decline, readmission, and length of stay at different follow-up points. A random-effects meta-analysis was performed using Hedges' gu and variance of relative risk (RR). RESULTS: GEMUs are organized in a heterogeneous way and the included studies gave no thorough description of comprehensive geriatric assessment (CGA). Involvement of a multidisciplinary team was a key element in all GEMUs. The individual trials showed that admission to a GEMU has one or more favorable effects on the outcomes of interest, with two significant effects in the meta-analysis: less functional decline at discharge from the GEMU (RR=0.87, 95% confidence interval (CI)=0.77-0.99; P=.04) and a lower rate of institutionalization 1 year after discharge (RR=0.78, CI=0.66-0.92; P=.003). For the other outcomes in the meta-analysis, a GEMU did not induce significantly different outcomes than usual care. CONCLUSION: This meta-analysis shows a significant effect in favor of the GEMU group on functional decline at discharge and on institutionalization after 1 year. There is heterogeneity between the studies, poor quality of some randomized controlled trials, and shortage of information about CGA. Multidisciplinary CGA offered in a GEMU may add value to the care for frail older persons admitted to the hospital, but the limitations confirm the need for well-designed studies using explicit CGA and more-structured and -coherent assessment instruments such as the Minimum Data Set Resident Assessment Instrument. [less ▲]

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See detailPrésentation
Pieron, Julien ULg

in Bulletin d'Analyse Phénoménologique (2010), 6(2), 1-2

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See detailLe Code des sociétés annoté
Caprasse, Olivier ULg

Book published by La Charte (2010)

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See detailEncéphalocèle orbitaire post-traumatique bilatéral
Racaru, Tudor ULg; Nguyen Khac, Minh-Tuan ULg; Scholtes, Félix ULg et al

in Revue Médicale de Liège (2010), 65

L'encéphalocèle orbitaire aigu traumatique est une entité rare. Selon Pubmed moins de 25 cas ont été raportés. Nous présentons le premier cas d'encéphalocèle post-traumatique bilatéral provoqué par une ... [more ▼]

L'encéphalocèle orbitaire aigu traumatique est une entité rare. Selon Pubmed moins de 25 cas ont été raportés. Nous présentons le premier cas d'encéphalocèle post-traumatique bilatéral provoqué par une fracture enfoncement du toit de l'orbite. Un traitement rapide est nécessaire pour éviter l'hypertension intra-orbitaire qui peut être responsable de lésions dégénératives du nerf optique. La réparation du toit de l'orbite nécessite une reconstruction rigide pour éviter la transmission de variations de la pression intra-crânienne. Dans le cas rapporté, la reconstruction du toit de l'orbite a été effectuée par voie crânienne sous-frontale à l'aide d'un mélange de poudre d'os à la colle biologique soutenu par un treillis en titane fixé avec des vis [less ▲]

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See detailInternational genomic co-operation; Who, what, when, where, why and how?
Cromie, A. R.; Berry, D. P.; Wickham, B. et al

in Interbull Bulletin (2010), 42

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See detailValorisation des déchets et sous-produits industriels en le génie civil
Courard, Luc ULg

Learning material (2010)

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