References of "2010"
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See detailA hybrid model for the simulation of angiogenesis during bone fracture healing
Geris, Liesbet ULg; Peiffer, Veronique; Gerisch, Alf et al

in Proceedings of the 17th conference of the European Society of Biomechanics (2010)

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See detailStrain-induced ferroelectricity in simple rocksalt binary oxides
Bousquet, Eric ULg; Spaldin, N.; Ghosez, Philippe ULg

in Physical Review Letters (2010), 104

Using first-principles density functional calculations, we show that ferroelectricity can be induced in simple alkaline-earth-metal binary oxides such as barium oxide (BaO) using appropriate epitaxial ... [more ▼]

Using first-principles density functional calculations, we show that ferroelectricity can be induced in simple alkaline-earth-metal binary oxides such as barium oxide (BaO) using appropriate epitaxial strains. Going beyond the fundamental discovery, we highlight that the functional properties (polarization, dielectric constant, and piezoelectric response) of such strained binary oxides are comparable in magnitude to those of typical ferroelectric perovskite oxides, making them of direct interest for applications. Finally, we show that magnetic binary oxides such as EuO, with the same rocksalt structure, behave similarly to the alkaline-earth-metal oxides, suggesting a route to new multiferroics combining ferroelectric and magnetic properties. [less ▲]

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See detailLocal Cooperativity in an Amyloidogenic State of Human Lysozyme Observed at Atomic Resolution.
Dhulesia, A.; Cremades, N.; Kumita, J. R. et al

in Journal of the American Chemical Society (2010)

The partial unfolding of human lysozyme underlies its conversion from the soluble state into amyloid fibrils observed in a fatal hereditary form of systemic amyloidosis. To understand the molecular ... [more ▼]

The partial unfolding of human lysozyme underlies its conversion from the soluble state into amyloid fibrils observed in a fatal hereditary form of systemic amyloidosis. To understand the molecular origins of the disease, it is critical to characterize the structural and physicochemical properties of the amyloidogenic states of the protein. Here we provide a high-resolution view of the unfolding process at low pH for three different lysozyme variants, the wild-type protein and the mutants I56T and I59T, which show variable stabilities and propensities to aggregate in vitro. Using a range of biophysical techniques that includes differential scanning calorimetry and nuclear magnetic resonance spectroscopy, we demonstrate that thermal unfolding under amyloidogenic solution conditions involves a cooperative loss of native tertiary structure, followed by progressive unfolding of a compact, molten globule-like denatured state ensemble as the temperature is increased. The width of the temperature window over which the denatured ensemble progressively unfolds correlates with the relative amyloidogenicity and stability of these variants, and the region of lysozyme that unfolds first maps to that which forms the core of the amyloid fibrils formed under similar conditions. Together, these results present a coherent picture at atomic resolution of the initial events underlying amyloid formation by a globular protein. [less ▲]

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See detailLes nouveaux défis de l'enseignement du français langue étrangère en Europe
Defays, Jean-Marc ULg

in Dialogues et Cultures (2010), 56

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See detailA new type of cubic-stacked layer structure in anthoinite, AlWO3(OH3)
Grey, I.; Madsen, I.; Mills et al

in American Mineralogist (2010), 95

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See detailThe society for Internet-based Scientific Studies : a new platform to promote multicentric studies in the Royal Belgian Society for Surgery
Bertrand, C. L.; Squifflet, Jean-Paul ULg; Gys, T. et al

in Acta Chirurgica Belgica (2010), 110

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See detailDroit de la responsabilité. Le domaine de la voirie
Durviaux, Ann-Lawrence ULg; Kohl, Benoît ULg; Fisse, Damien ULg

in Glansdroff, F.; Henry, P. (Eds.) Droit de la responsabilité. Domaines choisis (2010)

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See detailSelective epitaxial growth of III-V semiconductor heterostructures on Si substrates for logic applications
Nguyen, Ngoc Duy ULg; Wang, Gang; Brammertz, Guy et al

in ECS Transactions (2010), 33

We have deposited III-V alloys on 200 mm Si miscut wafers with an oxide pattern. The selective epitaxial growth (SEG) of GaAs in large windows defined by SiO2 lines on a thick strained-relaxed Ge buffer ... [more ▼]

We have deposited III-V alloys on 200 mm Si miscut wafers with an oxide pattern. The selective epitaxial growth (SEG) of GaAs in large windows defined by SiO2 lines on a thick strained-relaxed Ge buffer layer served as a test vehicle which allowed us to demonstrate the integration of a III-V material deposition process step in a Si manufacturing line using an industrial reactor. High quality GaAs layers with high wafer-scale thickness uniformity were achieved. In a subsequent step, SEG of InP was successfully performed on wafers with a 300 nm shallow trench isolation pattern. The seed layer morphology depended on the treatment of the Ge surface and on the growth temperature. The orientation of the trench with respect to the substrate miscut direction had an impact on the quality of the InP filling. Despite of the challenges, such an approach for the integration of III-V materials on Si substrates allowed us to obtain extended-defect-free epitaxial regions suitable for the fabrication of high-performance devices. [less ▲]

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See detailLa fonction guidage en micromécanique
Merken, Patrick; Debongnie, Jean-François ULg

Book published by DEBONGNIE (JEAN-FRANCOIS) (2010)

1) Modelling the stiffness of a circular notch hinge subjected to flexure, torsion or shear : asymptotic values for a vanishing thickness and correction factors for the general case. 2) Flexible membrane ... [more ▼]

1) Modelling the stiffness of a circular notch hinge subjected to flexure, torsion or shear : asymptotic values for a vanishing thickness and correction factors for the general case. 2) Flexible membrane : stiffness for vanishing radius ratio and correction factor for the general case. 3) Conclusion. 4) Appendices, including a summary of useful formulae. [less ▲]

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See detailA survey of honey bee colony losses in Belgium, fall 2008 to spring 2009
Nguyen, Bach Kim ULg; Mignon, Jacques ULg; Laget, D. et al

Conference (2010)

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See detailVersican overexpression in human breast cancer lesions: Known and new isoforms for stromal tumor targeting.
Kischel, Philippe ULg; Waltregny, David ULg; Dumont, Bruno ULg et al

in International Journal of Cancer = Journal International du Cancer (2010), 126(3), 640-50

Proteoglycans play a key role in cancer development and progression by participating in the constitution of a specific fertile tumor microenvironment. As they are largely overexpressed in the malignant ... [more ▼]

Proteoglycans play a key role in cancer development and progression by participating in the constitution of a specific fertile tumor microenvironment. As they are largely overexpressed in the malignant stroma, proteoglycans provide a reservoir of potential new targets for anticancer therapies, because they can serve to convey toxic payloads in the close proximity of cancer cells and subsequently destroy them. In this context, versican, a proteoglycan largely overexpressed in several solid cancers, bears the potential to be such an ideal target. As 4 main versican isoforms have been characterized, we sought to determine which isoform could represent the best target in human breast cancer. We used a series of 10 primary breast cancer lesions that were characterized as overexpressing the versican protein, when compared with matched normal breast tissues, using shotgun mass spectrometry and immunohistochemistry experiments. Quantitative polymerase chain reaction and western-blotting experiments were used to evaluate versican isoform expression in breast cancer/normal tissue pairs for which ARN quality was excellent. All known isoforms were significantly overexpressed in the malignant lesions, both at the mRNA and at the protein levels. In the course of this study, we also identified and cloned a new alternatively spliced versican isoform, referred to as V4, which was also found to be upregulated in human breast cancer. This study provides for the first time a comprehensive mRNA and protein analysis of versican isoforms expression in human breast tissues, and offers insights into which therapeutic strategy would be best suited to target versican in human breast cancer lesions. [less ▲]

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See detailExperimental investigation of the effect of flip bucket splitters on plunge pool geometry
Erpicum, Sébastien ULg; Archambeau, Pierre ULg; Dewals, Benjamin ULg et al

in RWTH - IWW (Ed.) Mitteilungen - 15. Deutsches Talsperrensymposium - Talsperren im Wandel (2010)

Flip buckets are common hydraulic structures aiming at deflecting high velocity flows to a free jet trajectory. Systematic experimental tests have been performed to assess the influence on energy ... [more ▼]

Flip buckets are common hydraulic structures aiming at deflecting high velocity flows to a free jet trajectory. Systematic experimental tests have been performed to assess the influence on energy dissipation and the plunge pool geometry of varied repartitions of splitters along the flip bucket width. In particular, it is shown that some configurations can create more erosion than a continuous channel without flip bucket. [less ▲]

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See detailQui dispose des dispositifs de médiation ?
Servais, Christine ULg

in Questions de Communication (2010), 10

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See detailCotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning.
Baron, Frédéric ULg; Lechanteur, Chantal ULg; Willems, Evelyne ULg et al

in Biology of Blood & Marrow Transplantation (2010), 16(6), 838-47

Recent studies have suggested that coinfusion of mesenchymal stem cells (MSCs) the day of hematopoietic cell transplantation (HCT) might promote engraftment and prevent graft-versus-host disease (GVHD ... [more ▼]

Recent studies have suggested that coinfusion of mesenchymal stem cells (MSCs) the day of hematopoietic cell transplantation (HCT) might promote engraftment and prevent graft-versus-host disease (GVHD) after myeloablative allogeneic HCT. This prompted us to investigate in a pilot study whether MSC infusion before HCT could allow nonmyeloablative (NMA) HCT (a transplant strategy based nearly exclusively on graft-versus-tumor effects for tumor eradication) from HLA-mismatched donors to be performed safely. Twenty patients with hematologic malignancies were given MSCs from third party unrelated donors 30-120 minutes before peripheral blood stem cells (PBSCs) from HLA-mismatched unrelated donors, after conditioning with 2 Gy total body irradiation (TBI) and fludarabine. The primary endpoint was safety, defined as a 100-day incidence of nonrelapse mortality (NRM) <35%. One patient had primary graft rejection, whereas the remaining 19 patients had sustained engraftment. The 100-day cumulative incidence of grade II-IV acute GVHD (aGVHD) was 35%, whereas 65% of the patients experienced moderate/severe chronic GVHD (cGVHD). One-year NRM (10%), relapse (30%), overall survival (OS) (80%) and progression-free survival (PFS) (60%), and 1-year incidence of death from GVHD or infection with GVHD (10%) were encouraging. These figures compare favorably with those observed in a historic group of 16 patients given HLA-mismatched PBSCs (but no MSCs) after NMA conditioning, which had a 1-year incidence of NRM of 37% (P = .02), a 1-year incidence of relapse of 25% (NS), a 1-year OS and PFS of 44% (P = .02), and 38% (P = .1), respectively, and a 1-year rate of death from GVHD or infection with GVHD of 31% (P = .04). In conclusion, our data suggest that HLA-mismatched NMA HCT with MSC coinfusion appeared to be safe. [less ▲]

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See detailFibromyalgia and related conditions: Electromyogram profile during isometric muscle contraction
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Dupont, Catherine ULg et al

in Joint Bone Spine (2010), 77

Objectives: To evaluate electromyogram (EMG) profiles in patients with three related conditions: fibromyalgia, chronic fatigue syndrome, and depression. Methods: We studied 44 healthy volunteers, 22 ... [more ▼]

Objectives: To evaluate electromyogram (EMG) profiles in patients with three related conditions: fibromyalgia, chronic fatigue syndrome, and depression. Methods: We studied 44 healthy volunteers, 22 patients with fibromyalgia, 11 patients with chronic fatigue syndrome, and 10 patients admitted for depression. The trapezius electromyogram was recorded during maximally sustained, bilateral, 90◦ abduction of the shoulders. EMG signal frequency and amplitude were measured throughout the test. Results: In the fibromyalgia group, isometric contraction duration was significantly shorter than in the other two patient groups (P < 0.001) and the EMG frequency and amplitude pattern indicated premature discontinuation of the muscle contraction. Findings in the chronic fatigue patients were similar to those in the healthy controls. The patients with depression had a distinctive EMG profile characterized by excessive initial motor-unit recruitment with a shift in the frequency spectrum. Conclusions: Fibromyalgia was associated with a specific EMG pattern indicating premature discontinuation of the muscle contraction. Therefore, maximal voluntary muscle contraction tests may be of limited value for assessing function in fibromyalgia patients. Chronic fatigue syndrome patients had similar EMG findings to those in the healthy controls. The EMG alterations in the patients with depression were consistent with manifestations of psychomotor retardation. [less ▲]

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See detailWord usage in scientific writing.
Van Damme, Hendrik ULg

in Acta Chirurgica Belgica (2010), 110(2), 137

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