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See detailEvaluation de l'efficacité des cultures intermédiaires pièges à nitrate (CIPAN) en novembre
Vandenberghe, Christophe ULg; Lambert, Richard; Marcoen, Jean Marie ULg

in Vandenberghe, Christophe; Marcoen, Jean Marie (Eds.) Actes de l'Atelier "Nitrate - Eau" 2 au 5 juin 2009. Peyresq, France (2010)

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See detailAdverbes de lieu, deixis et anaphore chez les historiens latins
Longrée, Dominique ULg

in De lingua latina (2010), 3

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See detailFamilles monoparentales: le passage de l'adolescence à l'absence d'un père
Malchair, Alain ULg

in Acta Psychiatrica Belgica (2010), 110(3), 36-42

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See detailTravaux pratiques en Histologie Humaine, Quadrimestre 4, 5 et 6
Defaweux, Valérie ULg; Mélot, France ULg; Florquin, Sandra ULg et al

Learning material (2010)

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See detailCrystal structure of a complex between the Actinomadura R39 DD-peptidase and a peptidoglycan-mimetic boronate inhibitor: interpretation of a transition state analogue in terms of catalytic mechanism.
Dzhekieva, Liudmila; Rocaboy, Mathieu ULg; Kerff, Frédéric ULg et al

in Biochemistry (2010), 49(30), 6411-9

The Actinomadura R39 DD-peptidase is a bacterial low molecular weight class C penicillin-binding protein. It has previously been shown to catalyze hydrolysis and aminolysis of small D-alanyl-D-alanine ... [more ▼]

The Actinomadura R39 DD-peptidase is a bacterial low molecular weight class C penicillin-binding protein. It has previously been shown to catalyze hydrolysis and aminolysis of small D-alanyl-D-alanine terminating peptides, especially those with a side chain that mimics the amino terminus of the stem peptide precursor to the bacterial cell wall. This paper describes the synthesis of (D-alpha-aminopimelylamino)-D-1-ethylboronic acid, designed to be a peptidoglycan-mimetic transition state analogue inhibitor of the R39 DD-peptidase. The boronate was found to be a potent inhibitor of the peptidase with a K(i) value of 32 +/- 6 nM. Since it binds some 30 times more strongly than the analogous peptide substrate, the boronate may well be a transition state analogue. A crystal structure of the inhibitory complex shows the boronate covalently bound to the nucleophilic active site Ser 49. The aminopimelyl side chain is bound into the site previously identified as specific for this moiety. One boronate oxygen is held in the oxyanion hole; the other, occupying the leaving group site of acylation or the nucleophile site of deacylation, appears to be hydrogen-bonded to the hydroxyl group of Ser 298. The Ser 49 oxygen appears to be hydrogen bonded to Lys 52. If it is assumed that this structure does resemble a high-energy tetrahedral intermediate in catalysis, it seems likely that Ser 298 participates as part of a proton transfer chain initiated by Lys 52 or Lys 410 as the primary proton donor/acceptor. The structure, therefore, supports a particular class of mechanism that employs this proton transfer device. [less ▲]

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See detailPotential Clinical and Economic Impact of Nonadherence with Osteoporosis Medications.
Hiligsmann, Mickaël ULg; Rabenda, Véronique ULg; Gathon, Henry-Jean ULg et al

in Calcified Tissue International (2010), 86

This study aims to estimate the potential clinical and economic implications of therapeutic adherence to bisphosphonate therapy. A validated Markov microsimulation model was used to estimate the impact of ... [more ▼]

This study aims to estimate the potential clinical and economic implications of therapeutic adherence to bisphosphonate therapy. A validated Markov microsimulation model was used to estimate the impact of varying adherence to bisphosphonate therapy on outcomes (the number of fractures and the quality-adjusted life-years [QALYs]), health-care costs, and the cost-effectiveness of therapy compared with no treatment. Adherence was divided into persistence and compliance, and multiple scenarios were considered for both concepts. Analyses were performed for women aged 65 years with a bone mineral density T-score of -2.5. Health outcomes and the cost-effectiveness of therapy improved significantly with increasing compliance and/or persistence. In the case of real-world persistence and with a medical possession ratio (MPR; i.e., the number of doses taken divided by the number of doses prescribed) of 100%, the QALY gain and the number of fractures prevented represented only 48 and 42% of the values estimated assuming full persistence, respectively. These proportions fell to 27 and 23% with an MPR value of 80%. The costs per QALY gained, for branded bisphosphonates (and generic alendronate), were estimated at <euro>19,069 (<euro>4,871), <euro>32,278 (<euro>11,985), and <euro>64,052 (<euro>30,181) for MPR values of 100, 80, and 60%, respectively, assuming real-world persistence. These values were <euro>16,997 (<euro>2,215), <euro>24,401 (<euro>6,179), and <euro>51,750 (<euro>20,569), respectively, assuming full persistence. In conclusion, poor compliance and failure to persist with osteoporosis medications results not only in deteriorating health outcomes, but also in a decreased cost-effectiveness of drug therapy. Adherence therefore remains an important challenge for health-care professionals treating osteoporosis. [less ▲]

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See detailCost-utility of long-term strontium ranelate treatment for postmenopausal osteoporotic women.
Hiligsmann, Mickaël ULg; Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2010), 21

The results of this study suggested that long-term treatment with strontium ranelate over 5 years is cost-effective compared to no treatment for postmenopausal osteoporotic women. INTRODUCTION: This study ... [more ▼]

The results of this study suggested that long-term treatment with strontium ranelate over 5 years is cost-effective compared to no treatment for postmenopausal osteoporotic women. INTRODUCTION: This study aims to estimate the cost-effectiveness of long-term strontium ranelate treatment for postmenopausal osteoporotic women. METHODS: A validated Markov microsimulation model with a Belgian healthcare cost perspective was used to assess the cost per quality-adjusted life-year (QALY) of strontium ranelate compared to no treatment, on a basis of calcium/vit D supplementation if needed. Analyses were performed for women aged 70, 75, and 80 years either with a bone mineral density T-score </= -2.5 SD or with prevalent vertebral fractures. The relative risk of fracture during therapy was derived from the Treatment of Peripheral Osteoporosis Study trial over 5 years of treatment. Parameter uncertainty was evaluated using both univariate and probabilistic sensitivity analyses. RESULTS: Strontium ranelate was cost-saving at the age of 80 years in both populations. For women with a T-score </= -2.5 SD, the costs per QALY gained of strontium ranelate were respectively <euro>15,096 and <euro>6,913 at 70 and 75 years of age while these values were <euro>23,426 and <euro>9,698 for women with prevalent vertebral fractures. Sensitivity analyses showed that the results were robust over a wide range of assumptions. CONCLUSION: This study suggested that, compared to no treatment, long-term strontium ranelate treatment is cost-effective for postmenopausal osteoporotic women. [less ▲]

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See detailL'inspecteur Convers et les intégristes
Mouton, Charles ULg

Book published by Persée (2010)

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See detailIII-V Devices for Advanced CMOS
Waldron, Niamh; Nguyen, Ngoc Duy ULg; Lin, Dennis et al

in 217th ECS Meeting (2010)

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See detailMatériaux composites
Courard, Luc ULg

Learning material (2010)

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See detailPenitence, Motherhood and Passion Devotion: Contextualising Anne of Brittany's Prayer Book, Chicago, Newberry Library, MS 83
L'Estrange, Elizabeth ULg

in Brown, Cynthia (Ed.) The Cultural and Political Legacy of Anne de Bretagne: Negotiating Convention in Books and Documents (2010)

Anne of Brittany’s prayer book, conserved in the Newberry Library in Chicago, has been somewhat neglected in discussions of Anne’s manuscripts. This may be because it has been eclipsed by those other, far ... [more ▼]

Anne of Brittany’s prayer book, conserved in the Newberry Library in Chicago, has been somewhat neglected in discussions of Anne’s manuscripts. This may be because it has been eclipsed by those other, far more luxurious and illustrated manuscripts owned by Anne, such as the Grandes Heures. However, the devotional themes of this small book, which dates from Anne’s second marriage, to Louis XII, reveal many of Anne’s interests as duchess of Brittany and queen of France. In particular the inclusion of a series of indulgences, an emphasis on St Anne, St Margaret, and St Louis, and a prayer said for the successful delivery of Clothilde, suggest that the prayer book was designed to articulate Anne’s place in the history of French monarchs, as well as her need to provide an heir for both the duchy of Brittany and the kingdom of France. This article seeks to place the little-known Newberry manuscript and its unusual contents in the context of what we already know of Anne’s devotional interests and the events of her life. Whereas previous scholarship on the manuscript, by Kamerick (Manuscripta, 1995) and L’Estrange (Holy Motherhood, 2008), has focused on the indulgences and childbearing aspects respectively, this article will bring these themes together, suggesting how the manuscript functioned as a whole, articulating a series of Breton and Capetian-Valois devotional legacies that were available to Anne as duchess and queen. Particular attention will be paid to the manuscript’s three miniatures, the illumination of David that opens the manuscript and the Penitential Psalms, and the two illuminations of Christ’s Passion. [less ▲]

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See detailFive years treatment with strontium ranelate reduces vertebral and nonvertebral fractures and increases the number and quality of remaining life-years in women over 80 years of age.
Seeman, Ego; Boonen, Steven; Borgstrom, Frederik et al

in BONE (2010), 46(4), 1038-42

INTRODUCTION: Longevity has resulted in a greater proportion of the population entering a time of life when increasing bone fragility and falls predispose to fractures, particularly nonvertebral fractures ... [more ▼]

INTRODUCTION: Longevity has resulted in a greater proportion of the population entering a time of life when increasing bone fragility and falls predispose to fractures, particularly nonvertebral fractures. Women over 80 years of age constitute 10% of the population but contribute 30% of all fractures and 60% of all nonvertebral fractures. Despite this, few studies have examined antifracture efficacy of treatments in this high-risk group and none has provided evidence for benefits beyond 3 years. MATERIALS AND METHODS: To determine whether strontium ranelate reduces the risk of vertebral and nonvertebral fractures during 5 years, we analyzed a subgroup of 1489 female patients over 80 years of age (mean 83.5+/-3.0 years) with osteoporosis from the SOTI (spinal osteoporosis therapeutic intervention) and TROPOS (treatment of peripheral osteoporosis) studies randomized to strontium ranelate 2 g/d or placebo. All received a supplement of calcium plus vitamin D. RESULTS: By intention to treat, vertebral fracture risk was reduced by 31% (relative risk, RR=0.69; 95% confidence interval, CI 0.52-0.92), nonvertebral fracture risk by 27% (RR=0.73; 95% CI 0.57-0.95), major nonvertebral fracture risk by 33% (RR=0.67; 95% CI 0.50-0.89) and hip fracture risk by 24% (RR=0.76; 95% CI 0.50-1.15, not significant). Treatment was cost-saving as it decreased cost and increased QALYs and life-years. DISCUSSION: Strontium ranelate safely produced a significant reduction in vertebral and nonvertebral fracture risk during 5 years in postmenopausal women over 80 years of age and was cost saving. [less ▲]

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See detailLe droit européen de la concurrence au banc des accusés
Petit, Nicolas ULg

in Revue de la Faculté de Droit de l'Université de Liège (2010), (2),

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See detailEffect of the Lengthening of the Protocol on the Reliability of Muscle Fatigue Indicators
Bosquet, Laurent; Maquet, Didier ULg; Forthomme, Bénédicte ULg et al

in International Journal of Sports Medicine (2010), 31(2), 82-88

The aim of this study was to examine absolute and relative reliability of fatigue measures calculated from peak torque or total work during 20, 30, 40 and 50 reciprocal maximal concentric contractions ... [more ▼]

The aim of this study was to examine absolute and relative reliability of fatigue measures calculated from peak torque or total work during 20, 30, 40 and 50 reciprocal maximal concentric contractions performed on an isokinetic dynamometer at 180 ° · s " 1 . Eighteen moderately active men performed 50 reciprocal maximal concentric contractions on three occasions with one 7 – 10 days recovery between each session. Peak torque and total work were computed for each contraction and subsequently summed to compute cumulated performance after respectively 20, 30, 40 and 50 repetitions. Muscle fatigue was determined after 20, 30, 40 and 50 repetitions by the fatigue index, the percent decrease in performance and the slope. Reliability of average peak torque or average total work was similar and was not a! ected by the lengthening of the protocol, although a learning e! ect was evident for knee flexors. Reliability of fatigue measures calculated from peak torque or total work was similar, improved with the lengthening of the protocol and was better for knee extensors. Measuring average peak torque or average total work and the slope during a protocol involving 30 maximal reciprocal concentric contractions appear to represent a better compromise between reliability and physiological interpretability of the data. [less ▲]

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See detaille bananier: de la plantation à la récolte
De Clerck, Caroline ULg; Lassois, Ludivine ULg

Diverse speeche and writing (2010)

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