References of "2010"
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See detailFormulation des bétons
Courard, Luc ULg

Learning material (2010)

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See detailNéerlandais / Presse radio
Yans, Baudoin ULg; Engelen, Nicole ULg; Nachtergaele, Lutgarde

Book published by De Boeck Université (2010)

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See detailCombined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female Beagle dogs
Noël, Stéphanie; Cambier, Carole; Baert, Kris et al

in Veterinary Journal (2010)

This study investigated the differences in pharmacokinetic, urodynamic and haemodynamic parameters in female Beagle dogs in which blood sampling and urethral pressure profiles were performed over 24 h ... [more ▼]

This study investigated the differences in pharmacokinetic, urodynamic and haemodynamic parameters in female Beagle dogs in which blood sampling and urethral pressure profiles were performed over 24 h periods, after single or three times daily (T0-T6h-T12h) administration of phenylpropanolamine (PPA). Maximal concentration (Cmax) was reached 2 h after PPA administration (Tmax). The half-life lasted 4 h and, because of bioaccumulation, three times daily administration induced an increase in Cmax. Compared to the control group, a significant increase in urethral resistance was observed at Tmax after 1 week of once daily administrations. After one week of administering PPA every 6 h during the daytime, but not during the night, and despite higher plasma concentrations, the urethral resistance did not increase at any time, compared to the control group. The increase in mean arterial pressure values was compensated by a decreased heart rate. The clinical efficacy of the temporary increase in urethral resistance following single daily administration of PPA in dogs suffering from urethral sphincter mechanism incompetence (USMI) needs to be further investigated in a randomised clinical trial. [less ▲]

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See detail@u monde, citoyen !
Jadoulle, Jean-Louis ULg

Book published by Didier Hatier (2010)

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See detailOceanic CO2 sink: the contribution of the marine cryosphere
Delille, Bruno ULg; Vancoppenolle, M.; Tilbrook, B. et al

Conference (2010)

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See detailVersican overexpression in human breast cancer lesions: Known and new isoforms for stromal tumor targeting.
Kischel, Philippe ULg; Waltregny, David ULg; Dumont, Bruno ULg et al

in International Journal of Cancer = Journal International du Cancer (2010), 126(3), 640-50

Proteoglycans play a key role in cancer development and progression by participating in the constitution of a specific fertile tumor microenvironment. As they are largely overexpressed in the malignant ... [more ▼]

Proteoglycans play a key role in cancer development and progression by participating in the constitution of a specific fertile tumor microenvironment. As they are largely overexpressed in the malignant stroma, proteoglycans provide a reservoir of potential new targets for anticancer therapies, because they can serve to convey toxic payloads in the close proximity of cancer cells and subsequently destroy them. In this context, versican, a proteoglycan largely overexpressed in several solid cancers, bears the potential to be such an ideal target. As 4 main versican isoforms have been characterized, we sought to determine which isoform could represent the best target in human breast cancer. We used a series of 10 primary breast cancer lesions that were characterized as overexpressing the versican protein, when compared with matched normal breast tissues, using shotgun mass spectrometry and immunohistochemistry experiments. Quantitative polymerase chain reaction and western-blotting experiments were used to evaluate versican isoform expression in breast cancer/normal tissue pairs for which ARN quality was excellent. All known isoforms were significantly overexpressed in the malignant lesions, both at the mRNA and at the protein levels. In the course of this study, we also identified and cloned a new alternatively spliced versican isoform, referred to as V4, which was also found to be upregulated in human breast cancer. This study provides for the first time a comprehensive mRNA and protein analysis of versican isoforms expression in human breast tissues, and offers insights into which therapeutic strategy would be best suited to target versican in human breast cancer lesions. [less ▲]

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See detailThe skin landscape following nonoptical capacitance imaging.
Xhauflaire, Emmanuelle ULg; Pierard, Gérald ULg; Quatresooz, Pascale ULg

in American Journal of Clinical Dermatology (2010), 11(2), 89-94

Skin capacitance is an electrical property measurable at the level of the stratum corneum. Values are related to the moisture content of the tissue. Using the silicon image sensor technology, it has ... [more ▼]

Skin capacitance is an electrical property measurable at the level of the stratum corneum. Values are related to the moisture content of the tissue. Using the silicon image sensor technology, it has recently become possible to measure capacitance at 50 microm intervals on the skin surface. The resulting nonoptical picture corresponds to skin capacitance imaging. This novel tool for dermatologists highlights with precision the hollow skin surface patterns, including dermatoglyphics, the patterns of the shallow skin lines, and wrinkles. The topographic heterogeneity in skin surface hydration is made visible. In addition, the sweat gland and follicular openings are disclosed. Skin disorders induced by surfactants or presenting as hyperkeratotic areas, including some neoplasms, may show typical aspects. It is concluded that skin capacitance imaging brings added value to the clinical assessment performed by dermatologists. [less ▲]

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See detailHydro-mechanical modelling of the Excavation Damaged Zone around an underground excavation at Mont Terri Rock Laboratory
Levasseur, Séverine ULg; Charlier, Robert ULg; Frieg, Bernd et al

in International Journal of Rock Mechanics & Mining Sciences (2010), 47(3), 414-425

A zone with significant irreversible deformations and significant changes in flow and transport properties is expected to be formed in indurated clay around underground excavations. The stress ... [more ▼]

A zone with significant irreversible deformations and significant changes in flow and transport properties is expected to be formed in indurated clay around underground excavations. The stress perturbation around the excavation could lead to a significant increase of the permeability, related to diffuse and/or localized crack propagation in the material. The main objective of the study is to model these processes at large scale in order to assess their impacts on the performance of radioactive waste geological repositories. This paper concerns more particularly the hydro-mechanical modelling of a long term dilatometer experiment performed in Mont Terri Rock Laboratory in Switzerland within the Selfrac Project. The proposed model defines the permeability as a function of the aperture of the cracks that are generated during the excavation. With this model, the permeability tensor becomes anisotropic. Advantages and drawbacks of this approach are described thanks to the results of the Selfrac long term dilatometer experiment. [less ▲]

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See detailL'organométallique au service des extraits naturels
Ramdani, R.; Ghazi, Z.; Fadel, O. et al

Poster (2010)

Le Maroc est considéré parmi les pays méditerranéens les plus riches en ressources naturelles, notamment, les plantes aromatiques et médicinales. La valorisation des extraits naturels passe soit par des ... [more ▼]

Le Maroc est considéré parmi les pays méditerranéens les plus riches en ressources naturelles, notamment, les plantes aromatiques et médicinales. La valorisation des extraits naturels passe soit par des échantillons à l’état brut, soit en les transformant en d’autres structures chimiques nouvelles. [less ▲]

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See detailFlow of magnetized grains in a rotating drum
Lumay, Geoffroy ULg; Vandewalle, Nicolas ULg

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2010)

We have experimentally investigated the influence of a magnetic interaction between the grains on the flow of a granular material in a rotating drum.

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See detailFunctionally active macrophage-derived myeloperoxidase in the skin of drug-induced toxic epidermal necrolysis.
Paquet, Philippe ULg; De Groote, Donat; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2010), 220(3), 201-7

BACKGROUND: Drug-induced toxic epidermal necrolysis (TEN) probably results from a complex and specific immune cell reaction involving lymphocytes and macrophages. OBJECTIVE: To assess the functional role ... [more ▼]

BACKGROUND: Drug-induced toxic epidermal necrolysis (TEN) probably results from a complex and specific immune cell reaction involving lymphocytes and macrophages. OBJECTIVE: To assess the functional role of macrophages in TEN. METHODS: Immunohistochemistry was performed on biopsies from early blisters developed in 9 TEN patients. The amount of extracellular myeloperoxidase (MPO) was measured by ELISA in TEN blister fluid and serum. Controls were blister fluids taken from 9 second-degree burns. In addition, 3-chlorotyrosine (a specific marker of MPO activity) was searched for using liquid mass chromatography both in TEN and burn blister fluids. RESULTS: Immunohistochemistry revealed numerous CD68+ macrophages in 8/9 TEN patients; 5-20% of these cells and rare CD15+ neutrophils exhibited MPO immunoreactivity, while keratinocytes were negative. The amount of MPO was significantly higher in TEN blister fluid than in TEN serum, suggesting macrophage production of MPO in the skin. In addition, MPO was significantly more abundant in TEN blister fluid than in burn blister fluid. 3-Chlorotyrosine was detected in 7/9 TEN blister fluids, but in only 2/9 burn blister fluids. DISCUSSION: MPO produced by macrophages was functionally active in most TEN patients, leading to the production of hypochlorous acid, a potent oxidative compound that alters keratinocytes. [less ▲]

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See detailNiveau de contamination et spéciation des métaux lourds dans l'Oued Fès et l'Oued Sebou.
Bouezmarni, Mohamed ULg; Debbaut, Vincent ULg; Diouri, S. El Edrissi et al

Conference (2010)

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See detailLes masses rétropéritonéales chez l’enfant : à propos d’une tumeur de Wilms et d’un neuroblastome
Malaise, Olivier ULg; Vandenbosch, Kristel ULg; Uyttebroeck, Anna et al

in Revue Médicale de Liège (2010), 65(3), 115-116

Detection of a retroperitoneal mass in children needs a fast and accurate exploration. We present the case- reports of 2 children under the age of 5 years admitted to the University Hospital of Liège, one ... [more ▼]

Detection of a retroperitoneal mass in children needs a fast and accurate exploration. We present the case- reports of 2 children under the age of 5 years admitted to the University Hospital of Liège, one with a Wilms tumor and one with a neuroblastoma. [less ▲]

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See detailDer Wandel nach der Wende. Theodor Storm nach den Ereignissen von 1848-51. Vom verlorenen Glauben an gesellschaftlichen Fortschritt zu der Erarbeitung fortschrittlicher Schreibstrategien
Gerrekens, Louis ULg

in Combes, André; Cozic, Alain; Lapchine, Nadia (Eds.) Tournant et (ré)écritures littéraires (2010)

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See detailMolecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation.
Yevenes, Gonzalo E; Moraga-Cid, Gustavo; Avila, Ariel et al

in Journal of Biological Chemistry (2010), 285(39), 30203-13

It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure. Thus, the differential ethanol ... [more ▼]

It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure. Thus, the differential ethanol sensitivity of diverse GlyR isoforms and mutants was explained by the presence of specific residues in putative alcohol pockets. Here, we demonstrate that ethanol sensitivity in two ligand-gated ion receptor members, the GlyR adult alpha(1) and embryonic alpha(2) subunits, can be modified through selective mutations that rescued or impaired Gbetagamma modulation. Even though both isoforms were able to physically interact with Gbetagamma, only the alpha(1) GlyR was functionally modulated by Gbetagamma and pharmacological ethanol concentrations. Remarkably, the simultaneous switching of two transmembrane and a single extracellular residue in alpha(2) GlyRs was enough to generate GlyRs modulated by Gbetagamma and low ethanol concentrations. Interestingly, although we found that these TM residues were different to those in the alcohol binding site, the extracellular residue was recently implicated in conformational changes important to generate a pre-open-activated state that precedes ion channel gating. Thus, these results support the idea that the differential ethanol sensitivity of these two GlyR isoforms rests on conformational changes in transmembrane and extracellular residues within the ion channel structure rather than in differences in alcohol binding pockets. Our results describe the molecular basis for the differential ethanol sensitivity of two ligand-gated ion receptor members based on selective Gbetagamma modulation and provide a new mechanistic framework for allosteric modulations of abuse drugs. [less ▲]

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See detailInorganic-binding peptides as tools for surface quality control
Vreuls, Christelle ULg; Zocchi, Germaine ULg; Genin, Alexis ULg et al

in Journal of Inorganic Biochemistry (2010)

This paper highlights an innovative application of inorganic-binding peptides as quality control tools for detecting defects on inorganic surfaces of any shape. The approach involves attaching a ... [more ▼]

This paper highlights an innovative application of inorganic-binding peptides as quality control tools for detecting defects on inorganic surfaces of any shape. The approach involves attaching a fluorescent label to an inorganic-binding peptide and exploiting the peptide's high binding specificity to detect, by simple fluorescence microscopy, chemical composition defects of microm size and crystallographic state defects. Proof of concept was demonstrated by monitoring binding of a previously isolated ZnO-binding peptide to galvanized steel substrates. The approach was further validated for TiO(2) coatings and stainless steel, with two new, specific inorganic-binding peptides isolated by phage display. [less ▲]

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See detailCurrent approaches to phylogenomic reconstruction
Baurain, Denis ULg; Philippe, Hervé

in Caetano-Anollés, Gustavo (Ed.) Evolutionary Genomics and Systems Biology (2010)

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See detailA grid for a precise analysis of daily activities
Wojtasik, Vinciane ULg; Olivier, Catherine ULg; Lekeu, Françoise ULg et al

in Neuropsychological Rehabilitation (2010), 20

Assessment of daily living activities is essential in patients with Alzheimer's disease. Most current tools quantitatively assess overall ability but provide little qualitative information on individual ... [more ▼]

Assessment of daily living activities is essential in patients with Alzheimer's disease. Most current tools quantitatively assess overall ability but provide little qualitative information on individual difficulties. Only a few tools allow therapists to evaluate stereotyped activities and record different types of errors. We capitalised on the Kitchen Activity Assessment to design a widely applicable analysis grid that provides both qualitative and quantitative data on activity performance. A cooking activity was videotaped in 15 patients with dementia and assessed according to the different steps in the execution of the task. The evaluations obtained with our grid showed good correlations between raters, between versions of the grid and between sessions. Moreover, the degree of independence obtained with our analysis of the task correlated with the Kitchen Activity Assessment score and with a global score of cognitive functioning. We conclude that assessment of a daily living activity with this analysis grid is reproducible and relatively independent of the therapist, and thus provides quantitative and qualitative information useful for both evaluating and caring for demented patients. [less ▲]

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