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See detailNovel peptide inhibiting both TEM-1 beta-lactamase and penicillin-binding proteins.
Phichith, Denis; Bun, Sylvie; Padiolleau-Lefevre, Severine et al

in The FEBS journal (2010), 277(23), 4965-72

9G4H9, a catalytic antibody displaying beta-lactamase-like activity, has been developed by the anti-idiotypic approach using beta-lactamase as the first antigen. Thus 9G4H9 represents the 'internal image ... [more ▼]

9G4H9, a catalytic antibody displaying beta-lactamase-like activity, has been developed by the anti-idiotypic approach using beta-lactamase as the first antigen. Thus 9G4H9 represents the 'internal image' of beta-lactamase. We selected a cyclic peptide anchored to a bacteriophage M13 library using 9G4H9 as the target. Pep90 is a cyclic heptapeptide enclosed between two cysteine residues. We showed that Pep90 could inhibit both TEM-1 beta-lactamase (K(i) = 333 mum) and several penicillin-binding proteins (IC(5)(0) values ranging from 6-62 mum). We determined that the tryptophan residue of Pep90 is of crucial importance for its inhibitory activity. Using Pep90 as a scaffold, we generated a new class of peptidomimetics that retained inhibitory activity towards TEM-1 beta-lactamase. [less ▲]

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See detailSubspace-based Methods for Machinery Analysis and Monitoring
Nguyen, Viet Ha ULg; Rutten, Christophe ULg; Golinval, Jean-Claude ULg

Conference (2010)

The objective of this presentation is to address the problem of structural damage detection or fault diagnosis in mechanical systems using subspace-based methods. Different methods are reviewed starting ... [more ▼]

The objective of this presentation is to address the problem of structural damage detection or fault diagnosis in mechanical systems using subspace-based methods. Different methods are reviewed starting from Principal Component Analysis (PCA) also known as Proper Orthogonal Decomposition (POD) of time responses. PCA is known as an efficient method for extracting modal features of linear structures from output-only measurements. Those features define a subspace which characterizes the dynamical behavior of the structure. It becomes than possible to detect structural damage by comparing a reference subspace (obtained from the healthy structure) with current subspaces on the basis of the concept of angles between subspaces. Other damage indexes based on statistics may also be used. One of the drawbacks of PCA is the need of several sensors. If the number of sensors is too small, modal identification and/or damage detection may not be performed in good conditions using PCA. An alternative PCA-based method named Null Subspace Analysis (NSA) may then be used. The NSA method generates data by means of block Hankel matrices and is proven to be efficient when the number of available sensors is small or even reduced to one sensor only. However, when damage activates nonlinearity, the detection problem may necessitate methods which are more sensitive to nonlinear behaviors. To this purpose, Kernel Principal Component Analysis (KPCA) is a nonlinear extension of PCA built to authorize features with nonlinear dependence between variables. The method is “flexible” in the sense that different kernel functions may be used to better fit the testing data. Industrial applications are presented to illustrate the proposed methods. [less ▲]

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See detailCambodian peasant’s contribution to rural development: a perspective from Kampong Thom Province
Diepart, Jean-Christophe ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2010), 14(2), 321-340

The paper aims to identify the rationality of peasant communities and their contribution to rural development in Kampong Thom province. To do so, an interdisciplinary analytical framework addresses the ... [more ▼]

The paper aims to identify the rationality of peasant communities and their contribution to rural development in Kampong Thom province. To do so, an interdisciplinary analytical framework addresses the dynamics of land use and land tenure, the strategies of labor force allocation as well as the determinants of land and labor agricultural productivities amongst peasant communities. It rests on details field surveys in two communes located in very distinct agro-ecological settings of Kampong Thom province. A land use change analysis based on time-series aerial photos is conducted with participatory inventories of natural resources. It shows that endogenous management of forest and fisheries resources generate significant incomes and, at the same time, contribute to maintaining biodiversity. The paper analyses how this contribution is challenged by the non-peasant actors involved in massive State land privatization. Aiming to full employment, peasant households enjoy a great flexibility in the way they allocate labor force, especially in line with the age of active labor and the fluctuation of labor opportunity costs. Principally due to an unequal land holding distribution, agricultural income is unfairly distributed but this inequality is actually balanced by the access to common-pool resources of crucial importance for the poorest and by the recourse to non farming activities, which is an important factor of socio-economic differentiation amongst households. The main economic indicators of rice production confirm that peasant households always try to maximize their income in step with the production factor they have in relatively less amount. A land market simulation stresses that, contrarily to theoretical assumptions, land access through sale (and purchase) does not result in a fairer land distribution. Nevertheless, land leases amongst peasant households seem more promising to ensure equitable access to land as they are embedded in collective security mechanisms activated by peasantry. The paper argues that peasant communities in the studied area constitute a solid basis for rural development as they offer a very good articulation between economic efficiency, social justice and environmental sustainability. Finally, recommendations are formulated to properly address peasant contribution to rural development in the new national agrarian policies. [less ▲]

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See detailVariability in carbon exchange of European croplands
Moors, E. J.; Jacobs, C.; Jans, W. et al

in Agriculture, Ecosystems & Environment (2010), 139

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See detailÀ l'Hôtel des Étrangers, repaire d'une bohème zutique
Saint-Amand, Denis ULg

in Brissette, Pascal; Glinoer, Anthony (Eds.) Bohème sans frontière. Production et internationalisation d'une posture. (2010)

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See detailIII-V Devices for Advanced CMOS
Waldron, Niamh; Nguyen, Ngoc Duy ULg; Lin, Dennis et al

in 217th ECS Meeting (2010)

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See detailSemi-solid metallic alloys modeling for the simulation of thixoforming processes
Koeune, Roxane ULg; Ponthot, Jean-Philippe ULg

in Vaz Jr., M.; de Souza Neto, E. A.; Munoz-Rojas, P. A. (Eds.) Computational Materials Modeling (2010)

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See detailLes cultes isiaques à Emporion
Puccio, Laetizia ULg

in Pallas : Revue d'Etudes Antiques (2010), 84

This article presents a new interpretation of the temple M's content placed in the so-called sanctuary of Asklepios in Emporion. The sculptures are related to an inscription of the area and also to a ... [more ▼]

This article presents a new interpretation of the temple M's content placed in the so-called sanctuary of Asklepios in Emporion. The sculptures are related to an inscription of the area and also to a sigilado glass and chandeliers that come from the Roman city. All this proves the presence of an Egyptian worship in Emporion more complex than earlier. [less ▲]

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See detailFirst man in the eastern Finland : an Early Mesolithic inland site with a red-ochre grave in Joensuu Rahakangas
Pesonen, Petro; Hertell, Esa; Nyholm, Mikael et al

Poster (2010)

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See detailCotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning.
Baron, Frédéric ULg; Lechanteur, Chantal ULg; Willems, Evelyne ULg et al

in Biology of Blood & Marrow Transplantation (2010), 16(6), 838-47

Recent studies have suggested that coinfusion of mesenchymal stem cells (MSCs) the day of hematopoietic cell transplantation (HCT) might promote engraftment and prevent graft-versus-host disease (GVHD ... [more ▼]

Recent studies have suggested that coinfusion of mesenchymal stem cells (MSCs) the day of hematopoietic cell transplantation (HCT) might promote engraftment and prevent graft-versus-host disease (GVHD) after myeloablative allogeneic HCT. This prompted us to investigate in a pilot study whether MSC infusion before HCT could allow nonmyeloablative (NMA) HCT (a transplant strategy based nearly exclusively on graft-versus-tumor effects for tumor eradication) from HLA-mismatched donors to be performed safely. Twenty patients with hematologic malignancies were given MSCs from third party unrelated donors 30-120 minutes before peripheral blood stem cells (PBSCs) from HLA-mismatched unrelated donors, after conditioning with 2 Gy total body irradiation (TBI) and fludarabine. The primary endpoint was safety, defined as a 100-day incidence of nonrelapse mortality (NRM) <35%. One patient had primary graft rejection, whereas the remaining 19 patients had sustained engraftment. The 100-day cumulative incidence of grade II-IV acute GVHD (aGVHD) was 35%, whereas 65% of the patients experienced moderate/severe chronic GVHD (cGVHD). One-year NRM (10%), relapse (30%), overall survival (OS) (80%) and progression-free survival (PFS) (60%), and 1-year incidence of death from GVHD or infection with GVHD (10%) were encouraging. These figures compare favorably with those observed in a historic group of 16 patients given HLA-mismatched PBSCs (but no MSCs) after NMA conditioning, which had a 1-year incidence of NRM of 37% (P = .02), a 1-year incidence of relapse of 25% (NS), a 1-year OS and PFS of 44% (P = .02), and 38% (P = .1), respectively, and a 1-year rate of death from GVHD or infection with GVHD of 31% (P = .04). In conclusion, our data suggest that HLA-mismatched NMA HCT with MSC coinfusion appeared to be safe. [less ▲]

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See detailElectrically addressing a molecule-like donor pair in silicon: An atomic scale cyclable full adder logic
YAN, Yonghong; Mol, J. A.; Verduijn, J. et al

in Journal of Physical Chemistry C: Nanomaterials, Interfaces, and Hard Matter (2010), 114

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See detailComment les parents, les enseignants et les cliniciens évaluent les troubles du comportement externalisé du jeune enfant ? Etude de la variabilité des jugements évaluatifs et de son impact sur le développement de l’enfant
Roskam, Isabelle; Stievenart, Marie ULg; Meunier, Jean-Christophe et al

in Pratiques Psychologiques (2010), 16

Cette contribution questionne nos pratiques d’évaluation du comportement chez le jeune enfant. Les données concernant le comportement de 118 enfants ont été collectées par questionnaires et observation ... [more ▼]

Cette contribution questionne nos pratiques d’évaluation du comportement chez le jeune enfant. Les données concernant le comportement de 118 enfants ont été collectées par questionnaires et observation auprès de leurs parents, leurs enseignants et les cliniciens lors du recrutement et après 12 mois. Les résultats indiquent une variabilité importante entre les jugements évaluatifs des différents informateurs et un impact négatif de cette variabilité sur le développement ultérieur de l’enfant. Les résultats plaident en faveur d’une procédure multi-informateurs et multiméthodes dont les implications sont discutées sur le plan clinique. [less ▲]

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See detailRevision and validation of the Family Apperception Test: some psychometric properties.
Roskam, Isabelle; Stievenart, Marie ULg; Deschuyteneer, Laurence et al

in The Family Journal (2010), 18(3),

The Family Apperception Test (FAT) is a projective assessment procedure based on the family system theory. FAT allows the subjects’ affects and feelings about their family to be assessed. The original ... [more ▼]

The Family Apperception Test (FAT) is a projective assessment procedure based on the family system theory. FAT allows the subjects’ affects and feelings about their family to be assessed. The original version and its French translation removed some of the conceptual and psychometric limitations of previous projective tests and family assessment procedures but several questions remained. The current study proposes several modifications to the conceptual background, administration, coding procedure, and standardization of the FAT, which considerably improve its psychometric properties. Data were collected on 168 typical and clinical children in the French-speaking part of Belgium. The results provide significant evidence for inter- and intra-assessor reliability; the factorial analysis and the internal consistency of the revised version were good; the FAT enabled us to discriminate between typical children and those in the clinical sample. The discussion focuses on the interest and limits of the quantitative coding procedure, based on several categories conceptualized as risk versus protective factors. The FAT is characterized by a complementary approach—both quantitative and qualitative—to the children and their families. [less ▲]

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See detailQui dispose des dispositifs de médiation ?
Servais, Christine ULg

in Questions de Communication (2010), 10

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See detailLa percepción de la Presidencia española del Consejo de la UE en la prensa extranjera
Natorski, Michal ULg

in Barbé, Esther (Ed.) Entre la irrelevancia internacional y el aprendizaje institucional: La presidencia española de la UE (2010) (2010)

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See detailEl Partenariado Oriental durante la presidencia española del Consejo de la UE: la gestión eficaz de unos objetivos modesto
Natorski, Michal ULg

in Barbé, Esther (Ed.) Entre la irrelevancia internacional y el aprendizaje institucional: La presidencia española de la UE (2010) (2010)

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See detailPreliminary safety assessment of Yarrowia lipolytica extracellular lipase : results of acute and 28-day repeated dose oral toxicity studies in rats
Turki, Saoussen; Jabloun, Zeineb; Mrabet, Ghada et al

in Food & Chemical Toxicology (2010), 48

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See detailL'image du mois. A propos d'un cas d'hémangiome intramusculaire récidivant
Brüls, Samuel ULg; KURTH, William ULg

in Revue Médicale de Liège (2010), 65(9), 483-5

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