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See detailModeling the morphology and mechanical behavior of shape memory polyurethanes based on solid-state NMR and synchrotron SAXS/WAXD
D'Hollander, Stijn; Gommes, Cédric ULg; Mens, Raoul et al

in Journal of Materials Chemistry (2010), 20

A combination of solid-state proton Wide-line Nuclear Magnetic Resonance (NMR) relaxometry and synchrotron Small-angle (SAXS) and Wide-angle (WAXD) X-ray scattering was used to elucidate the microphase ... [more ▼]

A combination of solid-state proton Wide-line Nuclear Magnetic Resonance (NMR) relaxometry and synchrotron Small-angle (SAXS) and Wide-angle (WAXD) X-ray scattering was used to elucidate the microphase morphology of shape memory thermoplastic multi-block polyurethanes based on poly(3-caprolactone), as switching segment and polyurethane based permanent or hard segments (HS). The polyurethanes are produced from the condensation of 1,4-butanediol (BDO) with hexamethylenediisocyanate (HDI). The morphology – induced by the hard-segment crystallization – converts from dispersed randomly placed hard-segment domains into progressively more periodic, but interconnected HS nanophases with increasing HS content. Irrespective of the actual morphology, the SAXS data could be described satisfactorily by using a clipped Gaussian random field (GRF) model. The NMR data demonstrate that the HS domain fraction corresponds to the chemical feed, pointing at a complete phase separation. The material mechanical behavior during repeated deformation cycles can be explained on morphological grounds and involves a spatially heterogeneous plastic deformation of the hard domains. [less ▲]

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See detailBreakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness.
Boveroux, Pierre ULg; Vanhaudenhuyse, Audrey ULg; Bruno, Marie-Aurélie ULg et al

in Anesthesiology (2010), 113(5), 1038-53

BACKGROUND: Mechanisms of anesthesia-induced loss of consciousness remain poorly understood. Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes ... [more ▼]

BACKGROUND: Mechanisms of anesthesia-induced loss of consciousness remain poorly understood. Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation of the level of consciousness. METHODS: Low-frequency spontaneous blood oxygen level-dependent fluctuations were measured in 19 healthy volunteers during wakefulness, mild sedation, deep sedation with clinical unconsciousness, and subsequent recovery of consciousness. RESULTS: Propofol-induced decrease in consciousness linearly correlates with decreased corticocortical and thalamocortical connectivity in frontoparietal networks (i.e., default- and executive-control networks). Furthermore, during propofol-induced unconsciousness, a negative correlation was identified between thalamic and cortical activity in these networks. Finally, negative correlations between default network and lateral frontoparietal cortices activity, present during wakefulness, decreased proportionally to propofol-induced loss of consciousness. In contrast, connectivity was globally preserved in low-level sensory cortices, (i.e., in auditory and visual networks across sedation stages). This was paired with preserved thalamocortical connectivity in these networks. Rather, waning of consciousness was associated with a loss of cross-modal interactions between visual and auditory networks. CONCLUSIONS: Our results shed light on the functional significance of spontaneous brain activity fluctuations observed in functional magnetic resonance imaging. They suggest that propofol-induced unconsciousness could be linked to a breakdown of cerebral temporal architecture that modifies both within- and between-network connectivity and thus prevents communication between low-level sensory and higher-order frontoparietal cortices, thought to be necessary for perception of external stimuli. They emphasize the importance of thalamocortical connectivity in higher-order cognitive brain networks in the genesis of conscious perception. [less ▲]

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See detailElectrospray mass spectrometry of noncovalent complexes between small molecule ligands and nucleic acids
Gabelica, Valérie ULg

in Joseph H., Banoub; Patrick A., Limbach (Eds.) Mass spectrometry of nucleosides and nucleic acids (2010)

CONTENTS 8.1 Introduction 8.1.1 ESI-MS of Noncovalent Complexes 8.1.2 Nucleic Acid Targeting by Small Molecules 8.2 Electrospray Mass Spectrometry of Nucleic Acid Noncovalent Complexes 8.2.1 ... [more ▼]

CONTENTS 8.1 Introduction 8.1.1 ESI-MS of Noncovalent Complexes 8.1.2 Nucleic Acid Targeting by Small Molecules 8.2 Electrospray Mass Spectrometry of Nucleic Acid Noncovalent Complexes 8.2.1 Stoichiometries: Number of Strands and Detection of Nucleic Acid Higher-Order Structures 8.2.2 Stoichiometries: Number of Bound Ligands 8.2.3 Role of Cations in Nucleic Acid Structure and Ligand Binding 8.2.4 Determination of Equilibrium Binding Constants 8.2.5 Are the Relative Intensities Proportional to the Abundances in Solution? 8.3 Characterizing Noncovalent Ligand Binding by MS/MS of the Complexes 8.3.1 Overview of Dissociation Pathways 8.3.2 How Observed Pathways Depend on Instrumental Parameters 8.3.3 How Observed Pathways Depend on Ligand Binding 8.3.4 Probing the Energetics of Ligand-DNA Interactions 8.3.5 Determining the Ligand Binding Mode 8.3.6 Determining the Ligand Binding Site by MS/MS 8.4 Conclusion and Outlook References [less ▲]

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See detailCentral nervous system: a conductor orchestrating metabolic regulations harmed by both hyperglycaemia and hypoglycaemia.
Scheen, André ULg

in Diabètes & Métabolism (2010), 36S3

Recent evidence suggests that the brain has a key role in the control of energy metabolism, body fat content and glucose metabolism. Neuronal systems, which regulate energy intake, energy expenditure, and ... [more ▼]

Recent evidence suggests that the brain has a key role in the control of energy metabolism, body fat content and glucose metabolism. Neuronal systems, which regulate energy intake, energy expenditure, and endogenous glucose production, sense and respond to input from hormonal and nutrient-related signals that convey information regarding both body energy stores and current energy availability. In response to this input, adaptive changes occur that promote energy homeostasis and the maintenance of blood glucose levels in the normal range. Defects in this control system are implicated in the link between obesity and type 2 diabetes mellitus. The central nervous system may be considered the conductor of an orchestra involving many peripheral organs involved in these homeostatic processes. However, the brain is mainly a glucose-dependent organ, which can be damaged by both hypoglycaemia and hyperglycaemia. Hypoglycaemia unawareness is a major problem in clinical practice and is associated with an increased risk of coma. Stroke is another acute complication associated with diabetes mellitus, especially in elderly people, and the control of glucose level in this emergency situation remains challenging. The prognosis of stroke is worse in diabetic patients and both its prevention and management in at-risk patients should be improved. Finally, chronic diabetic encephalopathies, which may lead to cognitive dysfunction and even dementia, are also recognized. They may result from recurrent hypoglycaemia and/or from chronic hyperglycaemia leading to cerebral vascular damage. Functional imaging is of interest for exploring diabetes-associated cerebral abnormalities. Thus, the intimate relationship between the brain and diabetes is increasingly acknowledged in both research and clinical practice. [less ▲]

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See detailSpatial avoidance of invading pastoral cattle by wild ungulates: insights from using point process statistics
Hibert, Fabrice; Calenge, Clément; Hervé, Fritz et al

in Biodiversity & Conservation (2010)

Traditional rangelands in many developing countries are currently being encroached by cultivation, driving some herders to illegally use protected areas for grazing their cattle. Since cattle are an ... [more ▼]

Traditional rangelands in many developing countries are currently being encroached by cultivation, driving some herders to illegally use protected areas for grazing their cattle. Since cattle are an exotic species in these ecosystems, they might have an impact on the local wild herbivore communities, notably through competition. We used point pattern statistics to characterise the spatial relationships between wild ungulate species and cattle herds within a protected area in west Africa undergoing seasonal intrusions by cattle. We predicted that the wild ungulate species that are ecologically and morphologically similar to cattle, in terms of body mass and diet, would be more sensitive to grass depletion by cattle and would be separated from cattle to a larger extent. The spatial distribution of browsing and mixed-feeding antelopes did not seem to be affected much by cattle presence, whereas most grazing species showed spatial separation from cattle. Interestingly, elephants also showed significant separation from cattle herds. We discuss the likely processes that may have contributed to the observed spatial patterns. Thespatial displacement of certain wild species, including megaherbivores, affects the whole community structure and, thus, other components of the ecosystem. [less ▲]

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See detailExposer la ville, un défi interdisciplinaire
Postula, Jean-Louis ULg

in Gob, André; Drouguet, Noémie (Eds.) La muséologie : Histoire, Développements, enjeux actuels (2010)

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See detailImmunoglobulines intraveineuses et maladie hémolytique allo-immune du nouveau-né.
Senterre, Thibault ULg; Viellevoye, Renaud ULg; Rigo, Jacques ULg

in Archives de Pédiatrie (2010), 17(3), 299-300

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See detailBovine herpesvirus 4 ORF73 is dispensable for viral growth in vitro but is essential for viral persistence in vivo.
Thirion, M.; Machiels, Bénédicte ULg; Farnir, Frédéric ULg et al

in Journal of General Virology (The) (2010), 91(10), 2574-84

ORF73 orthologues encoded by different rhadinoviruses have been studied extensively. These studies revealed that the ORF73 expression product (pORF73) is a multifunctional protein essential for latency ... [more ▼]

ORF73 orthologues encoded by different rhadinoviruses have been studied extensively. These studies revealed that the ORF73 expression product (pORF73) is a multifunctional protein essential for latency that enables episome tethering to mitotic chromosomes and modulates cellular pathways implicated in growth and survival of latently infected cells. Comparison of pORF73 orthologues encoded by rhadinoviruses reveals important variations in amino acid sequence length and composition. Bovine herpesvirus 4 (BoHV-4) encodes by far the shortest ORF73 orthologue with a size equivalent to only 22% of the largest orthologues. The present study focused on determining if BoHV 4 ORF73 is a bona fide gene and investigating whether it is essential for latency as established for larger ORF73 orthologues. Our results demonstrate that BoHV-4 ORF73 is transcribed as immediate-early bicistronic mRNA together with ORF71. Using a BoHV-4 bacterial artificial chromosome clone, we produced a strain deleted for ORF73 and a revertant strain. Deletion of BoHV-4 ORF73 did not affect the capacity of the virus to replicate in vitro, but it prevented latent infection in vivo using a rabbit model. Interestingly, the strain deleted for ORF73 induced an anti-BoHV-4 humoral immune response comparable to that elicited by wild-type and revertant recombinants. Together, these results demonstrate that despite its relatively small size, BoHV-4 ORF73 is a functional homologue of larger rhadinovirus ORF73 orthologues, and highlight the potential of ORF73 deletion for the development of BoHV-4 as a vector in vaccinology. [less ▲]

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See detailInfini actuel, infini potentiel
Bair, Jacques ULg; Henry, Valérie ULg

in Cohen, Gilles (Ed.) Mathématiques et philosophie (2010)

The classical analysis presents potentially the fundamental concepts (as limits, continuity, series, ...) of the calculus, while the non standard analysis gives an actual approach oh the same concepts.

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See detailInformation-Theoretic Inference of Gene Networks Using Backward Elimination.
Meyer, Patrick ULg; Marbach, Daniel; Roy, Sushmita et al

in BIOCOMP'10 (2010)

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See detailGenome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.
Anttila, Verneri; Stefansson, Hreinn; Kallela, Mikko et al

in Nature Genetics (2010), 42(10), 869-73

Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular ... [more ▼]

Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular markers for migraine have been convincingly established. We identified the minor allele of rs1835740 on chromosome 8q22.1 to be associated with migraine (P = 5.38 x 10, odds ratio = 1.23, 95% CI 1.150-1.324) in a genome-wide association study of 2,731 migraine cases ascertained from three European headache clinics and 10,747 population-matched controls. The association was replicated in 3,202 cases and 40,062 controls for an overall meta-analysis P value of 1.69 x 10(1)(1) (odds ratio = 1.18, 95% CI 1.127-1.244). rs1835740 is located between MTDH (astrocyte elevated gene 1, also known as AEG-1) and PGCP (encoding plasma glutamate carboxypeptidase). In an expression quantitative trait study in lymphoblastoid cell lines, transcript levels of the MTDH were found to have a significant correlation to rs1835740 (P = 3.96 x 10, permuted threshold for genome-wide significance 7.7 x 10. To our knowledge, our data establish rs1835740 as the first genetic risk factor for migraine. [less ▲]

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See detailPolymer/carbon nanotube composites for electromagnetic interference réduction
Thomassin, Jean-Michel ULg; Jérôme, Robert ULg; Detrembleur, Christophe ULg et al

in Tjong, S. C.; Mai, Y.-W. (Eds.) Physical properties and applications of polymer nanocomposites (2010)

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See detailOccurrence of equine coital exanthema in mares from an embryo transfer center
Barrandeguy, Maria; Perkins, Julio; Mac Donough, Jorge et al

in Journal of Equine Veterinary Science (2010), 30

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See detailBruit respiratoire et intolérance à l'effort: quel est votre diagnostic?
Van Erck, Emmanuelle ULg; Busoni, Valeria ULg

in Pratique Vétérinaire Equine (2010), 42(166), 57-60

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See detailPerformance monitoring of an industrial boiler: classification of relevant variables with Random Forests
Sainlez, Matthieu ULg; Heyen, Georges ULg

in Pierucci, Sauro; Ferraris, Guido Buzzi (Eds.) 20th European Symposium on Computer Aided Process Engineering – ESCAPE20 (2010)

A data mining methodology, the random forests, is applied to analyze pollutant emission from the recovery boiler of a Kraft pulping process. Starting from a large database of raw process data, the goal is ... [more ▼]

A data mining methodology, the random forests, is applied to analyze pollutant emission from the recovery boiler of a Kraft pulping process. Starting from a large database of raw process data, the goal is to identify the input variables that explain the most output variations. [less ▲]

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See detailEvolution of anatomical complexity, including an early type of cambium, in Psilophyton-grade plants.
Strullu-Derrien, Marie-Christine; Gensel, Patricia G.; Gerrienne, Philippe ULg

Conference (2010)

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See detailLate Tournaisian (Carboniferous) brachiopods from Mouydir (Central Sahara, Algeria)
Mottequin, Bernard ULg; Legrand-Blain, Marie

in Geological Journal (2010), 45

A small-sized brachiopod fauna, representing an orthid, rhynchonellid and spiriferid community which lived in a low-energy environment, is reported from the lower part of the Argiles de Teguentour and was ... [more ▼]

A small-sized brachiopod fauna, representing an orthid, rhynchonellid and spiriferid community which lived in a low-energy environment, is reported from the lower part of the Argiles de Teguentour and was collected around Oued Tamertasset (or Temertasset) and Oued Habadra in north-western Mouydir (Algerian Sahara). Associated goniatites indicate an early Late Tournaisian age (Pericyclus–Progoniatites assemblage). Thirteen brachiopod species belonging to 12 genera and 5 orders (Productida, Orthida, Rhynchonellida, Athyridida and Spiriferida) are described. Mouydirhynchus is proposed as a new rhynchonellid genus and the species Rhipidomella prolifica, Mouydirhynchus quietus and Eomartiniopsis mouydirensis are new. The other described taxa are the following: Chonetipustula? sp., strophalosioid gen. et sp. indet., Schizophoria sp., trigonirhynchiid gen. indet. sp. A, trigonirhynchiid gen. indet. sp. B, Hemiplethorhynchus? sp., Coveenia? sp., Crurithyris cf. fissa, Punctothyris? sp., and elythid gen. et sp. indet. [less ▲]

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