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See detailDam-break flow numerical modeling considering structural impacts on buildings
Erpicum, Sébastien ULg; Archambeau, Pierre ULg; Dewals, Benjamin ULg et al

in Proc. 33rd IAHR Congress: Water Engineering for a Sustainable Environment (2009)

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See detailSafety and efficacy of tibolone in breast cancer patients with vasomotor symptoms : a double-blind, randomised non inferiority tria
Kenemans, P.; Bundred, N. J.; Foidart, Jean-Michel ULg et al

in Lancet Oncology (2009), 10(2), 135-46

Background Vasomotor symptoms and bone loss are complications frequently induced by adjuvant treatment for breast cancer. Tibolone prevents both side-effects, but its effect on cancer recurrence is ... [more ▼]

Background Vasomotor symptoms and bone loss are complications frequently induced by adjuvant treatment for breast cancer. Tibolone prevents both side-effects, but its effect on cancer recurrence is unknown. The aim of this study was to show non-inferiority of tibolone to placebo regarding risk of recurrence in breast-cancer patients with climacteric complaints. Methods Between July 11, 2002, and Dec 20, 2004, women surgically treated for a histologically confirmed breast cancer (T1–3N0–2M0) with vasomotor symptoms were randomly assigned to either tibolone 2·5 mg daily or placebo at 245 centres in 31 countries. Randomisation was done by use of a centralised interactive voice response system, stratified by centre, with a block size of four. The primary endpoint was breast-cancer recurrence, including contralateral breast cancer, and was analysed in the intention-to-treat (ITT) and per-protocol populations; the margin for non-inferiority was set as a hazard ratio of 1·278. This study is registered with ClinicalTrials.gov, number NCT00408863. Findings Of the 3148 women randomised, 3098 were included in the ITT analysis (1556 in the tibolone group and 1542 in the placebo group). Mean age at randomisation was 52·7 years (SD 7·3) and mean time since surgery was 2·1 years (SD 1·3). 1792 of 3098 (58%) women were node positive and 2185 of 3098 (71%) were oestrogen-receptor positive. At study entry, 2068 of 3098 (67%) women used tamoxifen and 202 of 3098 (6·5%) women used aromatase inhibitors. The mean daily number of hot flushes was 6·4 (SD 5·1). After a median follow-up of 3·1 years (range 0·01–4·99), 237 of 1556 (15·2%) women on tibolone had a cancer recurrence, compared with 165 of 1542 (10·7%) on placebo (HR 1·40 [95% CI 1·14–1·70]; p=0·001). Results in the per-protocol population were similar (209 of 1254 [16·7%] women in the tibolone group had a recurrence vs 138 of 1213 [11·4%] women in the placebo group; HR 1·44 [95% CI 1·16–1·79]; p=0·0009). Tibolone was not different from placebo with regard to other safety outcomes, such as mortality (72 patients vs 63 patients, respectively), cardiovascular events (14 vs 10, respectively), or gynaecological cancers (10 vs 10, respectively). Vasomotor symptoms and bone-mineral density improved significantly with tibolone, compared with placebo. [less ▲]

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See detailGynaecological uses of a new class of steroids: the selective progesterone receptor modulators
Pintiaux, Axelle ULg; Chabbert-Buffet, N.; Foidart, Jean-Michel ULg

in Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology (2009), 25(2), 67-73

Selective progesterone receptor modulators (SPRM) represent a new class of synthetic steroids, which can interact with the progesterone receptor (PR) and can exert agonist, antagonist or mixed effects on ... [more ▼]

Selective progesterone receptor modulators (SPRM) represent a new class of synthetic steroids, which can interact with the progesterone receptor (PR) and can exert agonist, antagonist or mixed effects on various progesterone target tissues in vivo. This review evaluates the actual and potential usefulness of SPRMs in gynaecology [less ▲]

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See detailTroubles des émotions et de la cognition sociale. Traité de Neuropsychologie de l’enfant.
Catale, Corinne ULg; Willems, Sylvie ULg

in Poncelet, Martine; Majerus, Steve; Van der Linden, Martial (Eds.) Traité de Neuropsychologie de l’enfant (2009)

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See detailDifferential elevation of matrix metalloproteinase expression in women exposed to levonorgestrel-releasing intrauterine system for a short or prolonged period of time
Labied, Soraya ULg; Galant, C.; Nisolle, Michelle ULg et al

in Human Reproduction (2009), 24(1), 113-121

BACKGROUND: The levonorgestrel-releasing intrauterine system (LNG-IUS) is an effective contraceptive and has many non-contraceptive health benefits. However, it is commonly associated with irregular ... [more ▼]

BACKGROUND: The levonorgestrel-releasing intrauterine system (LNG-IUS) is an effective contraceptive and has many non-contraceptive health benefits. However, it is commonly associated with irregular endometrial bleeding. Metalloproteinases contribute to extracellular matrix (ECM) remodelling and regulate bleeding during the menstrual cycle. Enhanced metalloproteinase expression participates in the pathogenesis of breakthrough bleeding. Thus the objective of this study was to compare matrix metalloproteinase (MMP) expression in endometrium during luteal phase and in short-term (1 month) and long-term (> or =6 months) LNG-IUS users. METHODS: MMP expression was analysed by semi-quantitative RT-PCR and immunohistochemistry. Gelatinase activity was determined by gelatin zymography. RESULTS: MMP-1, -2, -3, -7, -9 and -12 mRNAs levels were increased, whereas that of MMP-26 was decreased in the endometrium of LNG-IUS users. MMP-1, -2, -3, -7 and -9 were localized by immunohistochemistry in all biopsies in the short-term group but in only 0-27% in the control group. The incidence of positive immunostaining for MMP-2 and -3 decreased significantly in the long-term compared with short-term LNG-IUS users. MMP-26 was localized in all biopsies from the control group but in only 14 and 25% from the short- and long-term LNG-IUS groups, respectively. In both LNG groups, the numbers of macrophages (the major source of MMP-12) was increased. CONCLUSIONS: MMP-1, active MMP-2, MMP-3, MMP-7, MMP-9 and MMP-12 are more prevalent in the short-term LNG-IUS group, suggesting their important contribution to ECM breakdown and transient bleeding. The decrease in the percentage of women expressing MMP-2 and -3 might contribute to the decreased occurrence of unwanted spotting and bleeding in long-term LNG-IUS users. [less ▲]

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See detailThe post-harvest quality of bananas is determined by pre-harvest factors
de Lapeyre de Bellaire, Luc; Chillet, Marc; Lassois, Ludivine ULg et al

Poster (2009)

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See detailDigimat Material eXpert – From the Material Lab to the Efficient and Optimal Design of Reinforced Plastic Parts
Depouhon, Alexandre ULg; Lepage, Séverine; Assaker, Roger

in Proceedings of EnginSoft International Conference 2009, CAE Technologies for Industry (2009)

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See detailReseña de América Latina en la “literatura mundial”, de Ignacio Sánchez-Prado (ed.)
Willson, Patricia ULg

in Iberoamericana (2009), 9(34), 223-226

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See detailCompte rendu de Heinz-Günther NESSELRATH (Hg.), "Platon. Kritias"
Gavray, Marc-Antoine ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2009), 78

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See detailFactors Affecting Plasma Pregnancy-associated Glycoprotein 1 Concentrations Throughout Gestation in High-producing Dairy Cows.
Serrano, B.; Lopez-Gatius, F.; Santolaria, P. et al

in Reproduction in Domestic Animals (2009), 44(4), 600-605

This study was designed to establish the factors, if any, which could affect plasma pregnancy-associated glycoprotein-1 (PAG-1) expression in a study population of 87 pregnant, high-producing dairy cows ... [more ▼]

This study was designed to establish the factors, if any, which could affect plasma pregnancy-associated glycoprotein-1 (PAG-1) expression in a study population of 87 pregnant, high-producing dairy cows. The factors examined were: semen providing breed (Holstein-Friesian vs Limousin), outcome of gestation (male vs female newborn, and singleton vs twin pregnancies), lactation number, milk production at pregnancy diagnosis, plasma progesterone concentration, season of gestation (warm period, March-November vs cool period, December-February), and day of gestation (40, 90, 120, 150, 180 and 210). Pregnancy was diagnosed by transrectal ultrasound on day 40 post-insemination and by palpation per rectum on days 90, 120, 150, 180 and 210. Blood samples were collected from each animal immediately before each pregnancy diagnosis. The relative contributions of the different factors on PAG-1 concentrations were evaluated by GLM repeated measures analysis of variance. No significant effects of the herd, foetal sex, milk production, lactation number and plasma progesterone concentrations were observed. In contrast, twin pregnancy, the use of Limousin semen and conception during the cool period were correlated with significantly increased plasma PAG-1 concentrations throughout gestation. Our data indicate that both cow well-being during early placental development, determined in our conditions by reduced heat stress when conception occurred in the cool season, and crossbreed pregnancies lead to improved PAG-1 production throughout the gestation period. [less ▲]

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See detailOptimization of external poly base sheet resistance in 0.13 µm quasi self-aligned SiGe:C HBTs
You, Suzhen; Van Huylenbroeck, Stefaan; Nguyen, Ngoc Duy ULg et al

in Thin Solid Films (2009), 518(6), 68

This paper investigates the optimization of the external polysilicon base sheet resistance of quasi self-aligned (QSA) SiGe:C HBTs from a 0.13 μm BiCMOS process. Taking advantage of optimized implant ... [more ▼]

This paper investigates the optimization of the external polysilicon base sheet resistance of quasi self-aligned (QSA) SiGe:C HBTs from a 0.13 μm BiCMOS process. Taking advantage of optimized implant conditions to improve the doping of the external base poly, and using an optimized non-selective epitaxy process with improved growth rate ratio of 1.7 between the polycrystalline silicon and monocrystalline silicon of the base, the maximum oscillation frequency fmax reaches 300 GHz. [less ▲]

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See detailImpaired respiration discloses the physiological significance of state transitions in Chlamydomonas.
Cardol, Pierre ULg; Alric, Jean; Girard-Bascou, Jacqueline et al

in Proceedings of the National Academy of Sciences of the United States of America (2009), 106(37), 15979-84

State transitions correspond to a major regulation process for photosynthesis, whereby chlorophyll protein complexes responsible for light harvesting migrate between photosystem II and photosystem I in ... [more ▼]

State transitions correspond to a major regulation process for photosynthesis, whereby chlorophyll protein complexes responsible for light harvesting migrate between photosystem II and photosystem I in response to changes in the redox poise of the intersystem electron carriers. Here we disclose their physiological significance in Chlamydomonas reinhardtii using a genetic approach. Using single and double mutants defective for state transitions and/or mitochondrial respiration, we show that photosynthetic growth, and therefore biomass production, critically depends on state transitions in respiratory-defective conditions. When extra ATP cannot be provided by respiration, enhanced photosystem I turnover elicited by transition to state 2 is required for photosynthetic activity. Concomitant impairment of state transitions and respiration decreases the overall yield of photosynthesis, ultimately leading to reduced fitness. We thus provide experimental evidence that the combined energetic contributions of state transitions and respiration are required for efficient carbon assimilation in this alga. [less ▲]

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See detailQuestions sur le questionnement des pratiques
Van Beveren, Julien ULg

in La Lettre de l'AIRDF (2009), 44

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See detailA risk-based analysis of the AAPS conference report on quantitative bioanalytical methods validation and implementation.
Boulanger, Bruno ULg; Rozet, Eric ULg; Moonen, Francois et al

in Journal of Chromatography. B : Analytical Technologies in the Biomedical & Life Sciences (2009), 877(23), 2235-43

The 3rd American Association of Pharmaceutical Scientists (AAPS)/Food and Drug Administration (FDA) Bioanalytical workshop in 2006 concluded with several new recommendations regarding the validation of ... [more ▼]

The 3rd American Association of Pharmaceutical Scientists (AAPS)/Food and Drug Administration (FDA) Bioanalytical workshop in 2006 concluded with several new recommendations regarding the validation of bioanalytical methods in a report published in 2007. It was aimed to conciliate or adapt validation principles for small and large molecules and an opportunity to revisit some of the major decision rules related to acceptance criteria given the experience accumulated since 1990. The purpose here is to provide a "risk-based" reading of the recommendations of 3rd AAPS/FDA Bioanalytical Workshop. Five decision rules were compared using simulations: the proposed pre-study FDA and Total Error Rules, the rules based on the beta-Expectation Tolerance and beta-gamma-Content Tolerance Interval and, finally, the 4-6-20 rule for in-study acceptance of runs. The simulation results demonstrated that the beta-Expectation Tolerance Rule controls appropriately the risk. The beta-gamma-Content Tolerance Interval was found to be too conservative, depending on the objective, and to lead to a high rate of rejection of procedures that could be considered as acceptable. On the other side, the FDA and the AAPS/FDA workshop Total Error Rule, combined or not, did not achieve their intended objective. With these rules, the risk is high to deliver results in study that would not meet the targeted acceptance criteria. This can be explained because, first, there is confusion between the quality of a procedure and the fitness of purpose of the results it could produce and, second, between the initial performances of a procedure, for example evaluated during pre-study validation and the quality of the future results. [less ▲]

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See detailLa plume du personnel scientifique. Un agenda de la recherche actuelle - Présentation du numéro
Cornet, Adeline ULg; Reuchamps, Min ULg; Van Aken, Nicolas ULg

in Revue de la Faculté de Droit de l'Université de Liège (2009), 54(4), 455-461

Cette présentation introduit le numéro spécial de la Revue de la Faculté de droit de l’Université de Liège qui réunit, comme son titre l’indique, un ensemble de contributions du « personnel scientifique » ... [more ▼]

Cette présentation introduit le numéro spécial de la Revue de la Faculté de droit de l’Université de Liège qui réunit, comme son titre l’indique, un ensemble de contributions du « personnel scientifique » de la Faculté de Droit et de Science politique – École liégeoise de Criminologie Jean Constant. Sommaire du numéro : Adeline CORNET, Min REUCHAMPS et Nicolas VAN AKEN, La plume du personnel scientifique ? Un agenda de la recherche actuelle Sophie WINTGENS, La politique internationale du Pakistan, un enjeu interne? Nicolas VAN AKEN, Les relations tumultueuses entre l'Emission Trading Scheme et le principe communautaire d'égalité: mariage forcé ou divorce à l'amiable? Vincent SERON, Casier judiciaire et délinquance sexuelle: quelques considérations autour d'un diptyque mémoire-oubli Arianne SALVE, La copropriété d'immeubles ou de groupe d'immeubles bâtis: un tour d'horizon de la réforme Min REUCHAMPS, Le fédéralisme et ses deux sens - négatifs - en Belgique francophone Grégory PIET, Retour en visibilité religions/religieux: analyse de leurs causes et conséquences européennes Geoffroy MATAGNE, Du conflit «révolutionnaire» au conflit «institutionnalisé»: étude des revendications centrifuges en Belgique Evelyne LANGENAKEN, La responsabilité du psychiatre - Piste de réflexion à l'issue du procès de Geneviève Lhermitte Geoffrey GRANDJEAN, Quelques réflexions sur les enjeux mémoriels autour de la répression du négationnisme en Belgique Corinne GERIN, Ambiguïté du stage parental ou chronique d'une mort annoncée Laurent FRANKIGNOUL, La crise bancaire de 2008, de Cleveland à Bruxelles Bertrand FINCOEUR, Jusqu'où va-t-on au nom de l'éthique? - La lutte antidopage dans le cyclisme sur route Teresa ELOLA CALDERON, Quels changements institutionnels le Traité de Lisbonne apporte-t-il à la Politique agricole commune (PAC) Alexandre DEFOSSEZ, L'effet direct horizontal des libertés communautaires et la liberté syndicale Adeline CORNET, Existe-t-il un modèle sexué dans les professions juridiques ? Analyse micro- et macrosociale du barreau et de la magistrature Charlotte BRAILLON, La théorie classique de la coutume et le rôle nouveau de l'opinio juris: Discours de la justice en droit international et en droit interne Adeline CORNET, Min REUCHAMPS et Nicolas VAN AKEN, La plume du personnel scientifique. Un agenda de la recherche actuelle - Epilogue: un numéro spécial et plus que cela [less ▲]

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See detailSerum Profiles of Pregnancy-Associated Glycoprotein, Oestrone Sulphate and Progesterone During Gestation and Some Factors Influencing the Profiles in Ethiopian Borana and Crossbred Cattle.
Lobago, F.; Bekana, M.; Gustafsson, H. et al

in Reproduction in Domestic Animals (2009), 44(4), 685-692

Contents This study presents serum concentrations of pregnancy-associated glycoprotein (PAG), oestrone sulphate (E1-S) and progesterone (P4), and the effects of some dam and foetus-related factors on ... [more ▼]

Contents This study presents serum concentrations of pregnancy-associated glycoprotein (PAG), oestrone sulphate (E1-S) and progesterone (P4), and the effects of some dam and foetus-related factors on these profiles during gestation in Borana and crossbred cattle. The PAG concentrations at 4th week post-conception ranged from 1.5-5.5 and 2.1-4.7 ng/ml in Borana (n = 6) and crossbred (n = 8) cattle, respectively. The mean PAG concentrations increased progressively from 4th to 33rd week of gestation (from 3.3-173 ng/ml for Borana and 4.2-240 ng/ml for crossbred cattle) and reached peak around calving. Breed, parity status, dam body weight, foetal sex and foetal birth weight significantly influenced the PAG concentrations. After delivery, the PAG concentrations declined steadily to 5.7 ng/ml in Borana (n = 7) and 3.9 ng/ml in crossbred (n = 6) cattle 10 weeks post-partum. The serum E1-S concentrations at 17th week of pregnancy ranged from 0.3-2.6 and 0.9-5.7 ng/ml in Borana (n = 8) and crossbred (n = 9) cattle, respectively. The mean E1-S concentrations increased progressively from 17th to 33rd week of gestation (from 1.1-4.6 ng/ml for Borana and 2.7-10.8 ng/ml for crossbred). Breed, parity status, dam body weight and foetal sex significantly influenced E1-S concentrations. The P4 concentrations at 4th week of pregnancy ranged from 3.2-5.1 and 1.7-8.9 ng/ml in Borana (n = 6) and crossbred (n = 8) cattle, respectively. The P4 level remained elevated throughout pregnancy. This study indicated that the serum PAG and P4 concentrations at 4th and E1-S approximately 17th week of pregnancy were above the cut-off value for pregnancy test and the hormonal profiles observed were comparable to the previous reports. Furthermore, the PAG and E1-S profiles were considerably influenced by factors such as breed, weight and parity status of the dam, and foetal sex and foetal birth weight (only PAG). [less ▲]

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See detailcompte rendu de : Christiane INGREMEAU Lactance. Institutions divines. Livre VI
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (2009), (4), 1117-1118

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See detailLa traduction dans l'antiquité
Rochette, Bruno ULg

Article for general public (2009)

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