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See detailSir Stirling Moss
Donnay, Jean-Paul ULg

Article for general public (2009)

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See detailCommon variants in the NLRP3 region contribute to Crohn's disease susceptibility.
Villani, Alexandra-Chloé; Lemire, Mathieu; Fortin, Geneviève et al

in Nature Genetics (2009), 41(1), 71-6

We used a candidate gene approach to identify a set of SNPs, located in a predicted regulatory region on chromosome 1q44 downstream of NLRP3 (previously known as CIAS1 and NALP3) that are associated with ... [more ▼]

We used a candidate gene approach to identify a set of SNPs, located in a predicted regulatory region on chromosome 1q44 downstream of NLRP3 (previously known as CIAS1 and NALP3) that are associated with Crohn's disease. The associations were consistently replicated in four sample sets from individuals of European descent. In the combined analysis of all samples (710 father-mother-child trios, 239 cases and 107 controls), these SNPs were strongly associated with risk of Crohn's disease (P(combined) = 3.49 x 10(-9), odds ratio = 1.78, confidence interval = 1.47-2.16 for rs10733113), reaching a level consistent with the stringent significance thresholds imposed by whole-genome association studies. In addition, we observed significant associations between SNPs in the associated regions and NLRP3 expression and IL-1beta production. Mutations in NLRP3 are known to be responsible for three rare autoinflammatory disorders. These results suggest that the NLRP3 region is also implicated in the susceptibility of more common inflammatory diseases such as Crohn's disease. [less ▲]

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See detailSources of phenotypic variation of life history traits in an invasive species, Senecio inaequidens DC. (Asteraceae)
Monty, Arnaud ULg; Mahy, Grégory ULg

Conference (2009)

The importance of different sources of phenotypic variation, namely adaptation, phenotypic plasticity, environmental maternal effects, ploidy level and genetic drift, were estimated in several life ... [more ▼]

The importance of different sources of phenotypic variation, namely adaptation, phenotypic plasticity, environmental maternal effects, ploidy level and genetic drift, were estimated in several life history traits among populations of an invasive plant species within its invasion range. Several common garden experiments were set out, two of which in a reciprocal transplants experiment. The populations considered in this study were located in Belgium, in France and in the native range of the model species. Senecio inaequidens DC. (Asteraceae) is native to Africa. It was introduced in Europe via wool trade in the late 19th century. In the native range, the species occurs at two co-existing cytotypes: diploid and tetraploid. Only tetraploid individuals are reported in Europe. The particular and well-documented invasion history of S. inaequidens makes it an excellent plant model for evolutionary studies. Several life history traits were measured, related to germination, growth and sexual reproduction. The sources of phenotypic variation in those traits were analysed with respect to climatic variation along altitudinal gradients in the invaded areas. The influence of the ploidy level and the range (native vs introduced) on those traits was also analysed. Results showed that diploid and tetraploid populations differed, mainly in winter survival capacity. Along altitudinal gradients, clinal phenotypic differentiations with a genetic basis were observed among populations. However, environmental maternal effects were found to significantly influence phenotypic variation in areas with harsh climatic conditions. Monty A., Mahy G. 2009. Clinal differentiation during invasion: Senecio inaequidens (Asteraceae) along altitudinal gradients in Europe. Oecologia 159:305–315. Monty A., Lebeau J., Meerts P., Mahy G. 2009. An explicit test for the contribution of environmental maternal effects to rapid clinal differentiation in an invasive plant. Journal of Evolutionary Biology22: 917-936 [less ▲]

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See detailCarte hydrogéologique de Wallonie 1/25000 71/5-6 Lamorteau-Ruette, notice explicative.
Bouezmarni, Mohamed ULg; Denne, Pierre; Debbaut, Vincent ULg

Book published by SPW, DGARNE - peer reviewed (2009)

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See detailExploratory approach on a relationship between ration and mastitis prevalence in dairy herds
Froidmont, Eric; Delfosse, C.; Planchon, V. et al

in Rencontres autour des Recherches sur les Ruminants (2009), 16

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See detailIntegral equation methods for the Helmholtz problem with a random impedance condition
Gaignaire, R.; Geuzaine, Christophe ULg

in Proceedings of the 9th International Conference on Mathematical and Numerical Aspects of Waves, Waves 2009 (2009)

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See detailDevelopment and Validation of a Markov Microsimulation Model for the Economic Evaluation of Treatments in Osteoporosis.
Hiligsmann, Mickaël ULg; Ethgen, Olivier ULg; Bruyère, Olivier ULg et al

in Value in Health (2009), 12(5), 687-696

ABSTRACT Objective: Markov models are increasingly used in economic evaluations of treatments for osteoporosis. Most of the existing evaluations are cohort-based Markov models missing comprehensive memory ... [more ▼]

ABSTRACT Objective: Markov models are increasingly used in economic evaluations of treatments for osteoporosis. Most of the existing evaluations are cohort-based Markov models missing comprehensive memory management and versatility. In this article, we describe and validate an original Markov microsimulation model to accurately assess the cost-effectiveness of prevention and treatment of osteoporosis. Methods: We developed a Markov microsimulation model with a lifetime horizon and a direct health-care cost perspective. The patient history was recorded and was used in calculations of transition probabilities, utilities, and costs. To test the internal consistency of the model, we carried out an example calculation for alendronate therapy. Then, external consistency was investigated by comparing absolute lifetime risk of fracture estimates with epidemiologic data. Results: For women at age 70 years, with a twofold increase in the fracture risk of the average population, the costs per quality-adjusted life-year gained for alendronate therapy versus no treatment were estimated at Euro 9105 and Euro 15,325, respectively, under full and realistic adherence assumptions. All the sensitivity analyses in terms of model parameters and modeling assumptions were coherent with expected conclusions and absolute lifetime risk of fracture estimates were within the range of previous estimates, which confirmed both internal and external consistency of the model. Conclusion: Microsimulation models present some major advantages over cohort-based models, increasing the reliability of the results and being largely compatible with the existing state of the art, evidence-based literature. The developed model appears to be a valid model for use in economic evaluations in osteoporosis. [less ▲]

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See detailBCOR analysis in patients with OFCD and Lenz microphthalmia syndromes, mental retardation with ocular anomalies, and cardiac laterality defects.
Hilton, Emma; Johnston, Jennifer; Whalen, Sandra et al

in European Journal of Human Genetics (2009), 17(10), 1325-35

Oculofaciocardiodental (OFCD) and Lenz microphthalmia syndromes form part of a spectrum of X-linked microphthalmia disorders characterized by ocular, dental, cardiac and skeletal anomalies and mental ... [more ▼]

Oculofaciocardiodental (OFCD) and Lenz microphthalmia syndromes form part of a spectrum of X-linked microphthalmia disorders characterized by ocular, dental, cardiac and skeletal anomalies and mental retardation. The two syndromes are allelic, caused by mutations in the BCL-6 corepressor gene (BCOR). To extend the series of phenotypes associated with pathogenic mutations in BCOR, we sequenced the BCOR gene in patients with (1) OFCD syndrome, (2) putative X-linked ('Lenz') microphthalmia syndrome, (3) isolated ocular defects and (4) laterality phenotypes. We present a new cohort of females with OFCD syndrome and null mutations in BCOR, supporting the hypothesis that BCOR is the sole molecular cause of this syndrome. We identify for the first time mosaic BCOR mutations in two females with OFCD syndrome and one apparently asymptomatic female. We present a female diagnosed with isolated ocular defects and identify minor features of OFCD syndrome, suggesting that OFCD syndrome may be mild and underdiagnosed. We have sequenced a cohort of males diagnosed with putative X-linked microphthalmia and found a mutation, p.P85L, in a single case, suggesting that BCOR mutations are not a major cause of X-linked microphthalmia in males. The absence of BCOR mutations in a panel of patients with non-specific laterality defects suggests that mutations in BCOR are not a major cause of isolated heart and laterality defects. Phenotypic analysis of OFCD and Lenz microphthalmia syndromes shows that in addition to the standard diagnostic criteria of congenital cataract, microphthalmia and radiculomegaly, patients should be examined for skeletal defects, particularly radioulnar synostosis, and cardiac/laterality defects. [less ▲]

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See detail"Metaboliquement obeses" sans exces de poids: un phenotype interpellant.
Beck, Emmanuel ULg; Scheen, André ULg

in Revue Médicale de Liège (2009), 64(1), 14-22

Obesity, especially abdominal obesity, is the main risk factor of metabolic syndrome. However, there are obviously non obese individuals who are metabolically abnormal and therefore exposed to an ... [more ▼]

Obesity, especially abdominal obesity, is the main risk factor of metabolic syndrome. However, there are obviously non obese individuals who are metabolically abnormal and therefore exposed to an increased risk of cardiovascular complications. Unfortunately, those persons fail to be detected because of a falsely reassuring body weight. The present paper aims at better understanding the etiopathogenesis and pathophysiology of this particular phenotype, at evaluating its potential clinical consequences and at describing the main principles of its therapeutic management. [less ▲]

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See detailFunctional analysis of an FLC-LIKE gene in root chicory
Périlleux, Claire ULg; Pieltain, Alexandra ULg; D'Aloia, Maria ULg et al

in Comparative Biochemistry and Physiology. Part A, Physiology (2009), 153A(2/Suppl.), 198-199

Vernalization is known to promote flowering in Arabidopsis thaliana by inhibiting the expression of a strong repressor: FLOWERING LOCUS C (FLC). The recent cloning of an FLC-LIKE gene in sugar beet (Beta ... [more ▼]

Vernalization is known to promote flowering in Arabidopsis thaliana by inhibiting the expression of a strong repressor: FLOWERING LOCUS C (FLC). The recent cloning of an FLC-LIKE gene in sugar beet (Beta vulgaris; BvFL1) and – here – in root chicory (Cichorium intybus; CiFL1) suggests the conservation of FLC biological function during evolution of eudicots. Hence physiological questions that remain difficult to address in Arabidopsis can be studied in other species. We investigated the correlation between CiFL1 expression and plant-age dependent responsiveness to vernalization. We also studied the effect of post-vernalization growing temperature, which can stabilize or erase the vernalized state. [less ▲]

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See detailEditorial : Les invasions biologiques ... appréhender la démesure
Vanderhoeven, Sonia ULg; Branquart, Etienne; Mahy, Grégory ULg

in Parcs & Réserves (2009), 3

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See detailPathologies sociales de la communication
Durand, Pascal ULg

in Questions de Communication (2009), 15

De la communication, souligner non les vertus, mais les vices ; examiner, au titre de ses pathologies - et plus spécialement de ses pathologies sociales -, non les biais dont elle peut faire l'objet, mais ... [more ▼]

De la communication, souligner non les vertus, mais les vices ; examiner, au titre de ses pathologies - et plus spécialement de ses pathologies sociales -, non les biais dont elle peut faire l'objet, mais ceux à la source desquels il arrive qu'elle se trouve ; l'envisager, non comme facteur de prévention ou de résorption de ces pathologies, mais plutôt comme leur éventuel vecteur d'aggravation circulaire, voilà comment pourrait être résumé à grands traits le propos du dossier ouvert dans la présente livraison de Questions de communication. Programme exorbitant : quelques articles réunis pour la cause ne sauraient épuiser ni même baliser avec précision une problématique pouvant aller, de façon très reçue, des phénomènes d'addiction électronique et des syndromes de déréalisation ou d'isolement induits par les technologies du virtuel aux dispositifs de propagande et autres techniques de lissage des différends politiques ou sociaux. Programme qui n'en paraîtra pas moins incongru au regard des conceptions enchantées de la communication et de la doxa qui l'institue non seulement en principe actif de la vie sociale en général, mais encore en ressource de première nécessité et en valeur indiscutable. [less ▲]

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See detailTests fractionnés de la capacité à réagir à des cas complexes en situation scolaire
Leclercq, Dieudonné ULg; Tooth, Alexandra; Delcomminette, Séverine ULg

in UCL (Ed.) Actes du Colloque (2009)

This testing design aims to assess, in a simulated way) a senior high school teacher competence that consists in being confronted with a problematic situation (a case) of school life that resort from ... [more ▼]

This testing design aims to assess, in a simulated way) a senior high school teacher competence that consists in being confronted with a problematic situation (a case) of school life that resort from educational psychology. In a first phase, data being insufficient, the teacher can merely elaborate a few explaining hypothesis. In a second phase, having obtained more information, he (she) can choose among a series of hypothesis the most likely one. In a third phase, if the hypothesis is confirmed, the teacher can imagine imagine his / her most appropriate reactions. In order to test simultaneously hundreds of students in the same amphitheatre, a series of sheets (formulas) are distributed, answered and then collected, additional information having ben provided in between two series of sheets. This explains the expression “fractionated”. [less ▲]

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See detailFormes et enjeux du premier Verlaine
Saint-Amand, Denis ULg

in Acta Fabula : Revue des Parutions en Théorie Littéraire (2009)

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See detailSocial Enterprise: the Shaping of a New Concept in a Comparative Regional Perspective
Defourny, Jacques ULg; Nyssens, Marthe

in Defourny, Jacques; Develtere, Patrick; Fonteneau, Bénédicte (Eds.) et al The Worldwide Making of the Social Economy. Innovations and Changes (2009)

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See detailThe main and accessory olfactory systems interact in the control of mate recognition and sexual behavior
Keller, M.; Baum, M. J.; Brock, Olivier ULg et al

in Behavioural Brain Research (2009)

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See detailRing dike system to harness floodwater from the Mekong River for paddy rice cultivation in the Tonle Sap Lake floodplain in Cambodia
Someth, Paradis; Kubo, Narita; Tanji, Hajime et al

in Agricultural Water Management (2009), 96

Located in the floodplain of the Mekong River and the Tonle Sap River, Batheay irrigation system and its reservoir directly receive floodwater from the Mekong. The Batheay reservoir formedby a ring dike ... [more ▼]

Located in the floodplain of the Mekong River and the Tonle Sap River, Batheay irrigation system and its reservoir directly receive floodwater from the Mekong. The Batheay reservoir formedby a ring dike functions as botha reservoir anda paddy field. In thewet season, the ring dike prevents floodwater fromentering the reservoir and rainy season rice is growninside the dike. After harvesting, the gateson the ring dike are openedto receive floodwater. The water is stored inside the dike for cultivating dry season rice outside the dike. In this paper, the irrigation system is studied as a model site for future development of the floodplain of the Tonle Sap Lake of Cambodia. Specifically, this paper is concerned with the study of water balance and analysis of the hydrologic components of the Batheay irrigation system, and the effectiveness of the ring dike system. The study found that floodwater of the Mekong River contributed about 74% to the total inflow to the Batheay reservoir. Contributions to the total water supply of reservoir water, floodwater remaining in the fields, and precipitation were 73, 12, and 15%, respectively. The efficiency of the systemwas found to be 92%. The dike system is expected to be a paradigm for the floodplain of the Tonle Sap Lake. [less ▲]

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See detailEconomie plurielle et régulation publique. Le quasi-marché des titres-services en Belgique
Henry, Arnaud; Nassaut, Stéphane; Defourny, Jacques ULg et al

Book published by Academia Press (2009)

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See detailComparative analysis of painting recipes: a new contribution to the study of the texts of the Strasbourg family
Neven, Sylvie ULg

in HERMENS, Erma; TOWNSEND, Joyce (Eds.) Sources and Serendipity. Testimonies of Artists’ Practice (2009)

For many years, the Strasbourg Manuscript was believed to be the oldest German-language source for the study of Northern European painting techniques. Unfortunately, the manuscript was lost in the 1870 ... [more ▼]

For many years, the Strasbourg Manuscript was believed to be the oldest German-language source for the study of Northern European painting techniques. Unfortunately, the manuscript was lost in the 1870 fire at the Strasbourg Library, and the text only survives in a 19th-century transcription made for Eastlake (1847). Studies such as those of Ploss and more recently those of Oltrogge have already highlighted the existence of texts with very similar contents, grouping them under the name of the ‘Strasbourg family’. Since these studies, a clearly defined corpus of manuscripts has been established as belonging to this family. This paper shows the different degrees of connection between the texts and presents some suggestions concerning their compilation process. The possibility of collating different versions of an identical text and cross-checking recipes can also be exploited to learn more about the ways in which recipe books were compiled, and to provide information concerning their use and function. [less ▲]

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