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See detailDétection du cancer de la vessie à partir d'échantillons d'urine
Thomas, Alexandre ULg; Renard, Isabelle; Waltregny, David ULg

in Revue Médicale de Liège (2009), 64

Bladder cancer mainly affects patients aged 50 years or more and requires close and repeated surveillance. Flexible cystoscopy associated with urinary cytology are the currently recommended diagnostic and ... [more ▼]

Bladder cancer mainly affects patients aged 50 years or more and requires close and repeated surveillance. Flexible cystoscopy associated with urinary cytology are the currently recommended diagnostic and follow-up methods. Because medical imaging techniques remain rather unsatisfying for bladder carcinoma detection, research efforts have focused on urinary markers of the disease. Various approaches were tested with results generally too unconsistant to replace cystoscopy. Recently, the department of Urology at the University of Liège together with the Biotechnology Company OncoMethylome Sciences have been interested in testing whether the detection of hypermethylated genes in voided urine samples would be of value for the detection of bladder cancer. The method is based on the Methylation-Specific PCR technology (MSP). This approach has the theoretical advantage of being non invasive, reproducible and based on DNA, whose stability, in urine, is higher than that of proteins. The results of a large prospective study, recently publised in European Urology, have shown that the identification by MSP of 2 methylated genes, TWIST1 and NID2, in voided urine samples, is a sensitive (+/- 90%) and specific (+/- 93%) test for the detection of bladder cancer. The test is largely more sensitive than cytology while both techniques have similar specificity. Based on these promising results, we are currently evaluating this novel, non invasive MSP approach for the follow-up of patients with non-muscle invasive bladder cancer. [less ▲]

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See detailLe diagnostic précoce des cancers de la peau est primordial
PIERARD, Gérald ULg; ANDRE, J.; BROCHEZ, L. et al

Book published by bioderma (2009)

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See detailEditorial : Les invasions biologiques ... appréhender la démesure
Vanderhoeven, Sonia ULg; Branquart, Etienne; Mahy, Grégory ULg

in Parcs & Réserves (2009), 3

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See detailClose-packed array of gold nanoparticles and Sum Frequency Generation spectroscopy in total internal reflection: A platform for studying biomolecules and biosensors
Tourillon, Gérard; Dreesen, Laurent ULg; Volcke, Cédric et al

in Journal of Materials Science (2009), 44(24), 6805-6810

An approach is introduced for studying the adsorption and recognition mechanisms of biomolecules, without using any markers. We show for the first time, that the Sum Frequency Generation spectroscopy ... [more ▼]

An approach is introduced for studying the adsorption and recognition mechanisms of biomolecules, without using any markers. We show for the first time, that the Sum Frequency Generation spectroscopy performed in the Total Internal Reflection (TIR-SFG) geometry, combined with a regular close-packed array of gold nanoparticles allows to probe with a high sensitivity the changes in conformation and orientation induced by the recognition process of avidin by biocytin. This approach represents a new platform with potential use in biosensors, diagnostics and bioactive layers. [less ▲]

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See detailEvaluation of the endorcine disrupting chemicals contamination in the North Sea porpoise population using in vitro assays
Didimo Imazaki, Pedro Henrique ULg; Brose, François ULg; Van Der Heiden, Edwige ULg et al

Poster (2009)

During the last decades, the production endocrine disrupting chemicals reached such levels that they are now spread all over nature. They are known to be very slowly degraded, decreasing the environmental ... [more ▼]

During the last decades, the production endocrine disrupting chemicals reached such levels that they are now spread all over nature. They are known to be very slowly degraded, decreasing the environmental quality and posing ecological risks. Marine mammals inhabiting polluted environments accumulate high levels of these chemicals, so they can be considered good indicators of marine pollution. Thirteen major organochloride pollutants were chosen to make subject of this study: o,p’-DDD; p,p’-DDD; p,p’-DDE; o,p’-DDT; p,p’-DDT; HCB; α-HCH; β-HCH; γ-HCH; δ-HCH; PCB 138; PCB 153 and PCB 180. All these chemicals will have their endocrine disrupting effects characterized individually and collectively by report gene expression assays. The MCF7-ERE cells used in these assays were produced in the Molecular Biology and Genetic Engineering Laboratory of the University of Liège and are originated from a human mammary carcinoma. They carry a gene expressing the synthesis of luciferase and controlled by oestrogen receptors. Then, the thirteen chemicals will be searched in the blubber tissues of porpoises by the use of gas chromatography-mass spectrometry. The blubber samples will also have their endocrine disrupting effect characterized. For the moment, the estrogenic effects of the HCH isomers were put in evidence. The next steps of this work must be soon accomplished. It is expected a great level of these compounds to be found in the samples. On the other hand, their endocrine disrupting effects and how they act in agonist, antagonist and synergist ways are subject that still needs to be cleared. [less ▲]

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See detailLa guerra dei Sei Giorni: lunedì, il giorno dell’attacco
Cuau, Ives; Ricciardi, Stefania ULg

in Barillari, Simone (Ed.) La guerra a un passo (2009)

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See detailOptimal rail-road container terminal locations on the European network
Limbourg, Sabine ULg; Jourquin, Bart

in Transportation Research. Part E: Logistics and Transportation Review (2009), 45(4), 551-563

The European transport policy has focused on sustainable transport solutions, among which intermodal transport is a key player. However, its efficiency is strongly dependent on the location of the ... [more ▼]

The European transport policy has focused on sustainable transport solutions, among which intermodal transport is a key player. However, its efficiency is strongly dependent on the location of the container terminals. In this paper, a set of estimated potential locations is used as input for an iterative procedure based on the p-hub median problem that takes the variation in trans-shipment costs according to the number of trans-shipped containers into account. The final results are the optimal locations for European transfer terminals embedded in a hub-and-spoke network. [less ▲]

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See detailAttentional and executive functioning following mild traumatic brain injury in children using the Test for Attentional Performance (TAP) battery
Catale, Corinne ULg; Marique, Patrica; Closset, Annette et al

in Journal of Clinical & Experimental Neuropsychology (2009), 31(3), 331-338

The interpretation of the data regarding cognitive outcome in children who have suffered from mild traumatic brain injury (MTBI) remains currently controversial. The aim of the present study is to explore ... [more ▼]

The interpretation of the data regarding cognitive outcome in children who have suffered from mild traumatic brain injury (MTBI) remains currently controversial. The aim of the present study is to explore attentional and executive functioning in 6–12-year-old children who experienced a MTBI. A total of 15 children with MTBI and 15 matched noninjured children participated in the study. Attentional tasks using the Test for Attentional Performance battery were administered one year after the injury. In comparison to the noninjury children, MTBI children performed less accurately on selective attentional and updating tasks. These preliminary findings support the view that MTBI can have an impact on specific attentional functioning in children one year postinjury. [less ▲]

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See detailAdhesion and growth inhibitory effect of chicken egg yolk antibody (IgY) on Salmonella enterica serovars Enteritidis and Typhimurium in vitro.
Chalghoumi, Raja; Thewis, André ULg; Beckers, Yves ULg et al

in Foodborne Pathogens and Disease (2009), 6(5), 593-604

The protective effects of powder preparation of egg yolk immunoglobulin Y (IgY), specific to Salmonella Enteritidis and Salmonella Typhimurium outer membrane proteins (OMP), against these two Salmonella ... [more ▼]

The protective effects of powder preparation of egg yolk immunoglobulin Y (IgY), specific to Salmonella Enteritidis and Salmonella Typhimurium outer membrane proteins (OMP), against these two Salmonella sp. serovars were investigated in vitro in two different assays: adhesion-prevention and growth-inhibition. The adhesion-prevention assay was conducted using polarized monolayers of the human intestinal epithelial Caco-2 cell line. First, the conditions of Salmonella adherence to Caco-2 cells were optimized, and interferences of bacteria with the transepithelial electrical resistance (TER) of fully differentiated Caco-2 cell monolayers and the lactate dehydrogenase release upon exposure of the cells to Salmonella were evaluated. Both Salmonella sp. serovars were able to adhere to Caco-2 cells and decreased TER. Results from the adhesion-prevention assay demonstrated that specific IgY reduced the decrease in TER of the infected Caco-2 cell monolayers and blocked the Salmonella sp. adhesion in a concentration-dependent manner (p < 0.05). Nonspecific IgY also exhibited an inhibitory effect on these two parameters, but to a lesser extent than that of the specific IgY (p < 0.05). The protective effect of nonspecific IgY could be attributed to the low-density lipoprotein component of the water-soluble fraction of egg yolks that may not have been eliminated during ultrafiltration. The growth-inhibition assay revealed that specific IgY had an inhibitory effect on the bacterial growth, markedly during the late exponential phase, whereas nonspecific IgY failed to do so. Taken together, these results suggest that the in vitro growth inhibitory effect of specific IgY on Salmonella spp. resulted from the specific binding activity of these IgY to Salmonella sp. OMP. Passive immunization with Salmonella sp. OMP-specific IgY could thus be useful to prevent Salmonella colonization in broiler chickens and the subsequent carcass contamination during processing. [less ▲]

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See detailAssessing the Potential of Zwitterionic NHC•CS2 Adducts for Probing the Stereoelectronic Parameters of N-Heterocyclic Carbenes
Delaude, Lionel ULg; Demonceau, Albert ULg; Wouters, Johan

in European Journal Of Inorganic Chemistry (2009), (13), 1882-1891

Five imidazol(in)ium-2-dithiocarboxylates bearing cyclohexyl, mesityl, or 2,6-diisopropylphenyl substituents on their nitrogen atoms were prepared from the corresponding N-heterocyclic carbenes (NHCs) by ... [more ▼]

Five imidazol(in)ium-2-dithiocarboxylates bearing cyclohexyl, mesityl, or 2,6-diisopropylphenyl substituents on their nitrogen atoms were prepared from the corresponding N-heterocyclic carbenes (NHCs) by reaction with carbon disulfide. They were characterized by IR, UV/Vis, and NMR spectroscopy, and by thermogravimetric analysis. Their molecular structures were determined by X-ray diffraction. For the sake of comparison, tricyclohexylphosphonium dithiocarboxylate was also examined. The data acquired were scrutinized to evaluate their usefulness for assessing the steric and electronic properties of NHC ligands. Because of their outstanding ability to crystallize, the five NHC center dot CS2 betaines were found to be highly suitable for probing the steric influence of nitrogen atom substituents on imidazolylidene-based ligand precursors via XRD analysis, while the corresponding NHC center dot CO2 adducts were deemed more appropriate for evaluating the sigma-donating properties of carbene ligands. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) [less ▲]

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See detailComparative analysis of painting recipes: a new contribution to the study of the texts of the Strasbourg family
Neven, Sylvie ULg

in HERMENS, Erma; TOWNSEND, Joyce (Eds.) Sources and Serendipity. Testimonies of Artists’ Practice (2009)

For many years, the Strasbourg Manuscript was believed to be the oldest German-language source for the study of Northern European painting techniques. Unfortunately, the manuscript was lost in the 1870 ... [more ▼]

For many years, the Strasbourg Manuscript was believed to be the oldest German-language source for the study of Northern European painting techniques. Unfortunately, the manuscript was lost in the 1870 fire at the Strasbourg Library, and the text only survives in a 19th-century transcription made for Eastlake (1847). Studies such as those of Ploss and more recently those of Oltrogge have already highlighted the existence of texts with very similar contents, grouping them under the name of the ‘Strasbourg family’. Since these studies, a clearly defined corpus of manuscripts has been established as belonging to this family. This paper shows the different degrees of connection between the texts and presents some suggestions concerning their compilation process. The possibility of collating different versions of an identical text and cross-checking recipes can also be exploited to learn more about the ways in which recipe books were compiled, and to provide information concerning their use and function. [less ▲]

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See detailInferring bounds on the performance of a control policy from a sample of trajectories
Fonteneau, Raphaël ULg; Murphy, Susan; Wehenkel, Louis ULg et al

in Proceedings of the IEEE International Symposium on Adaptive Dynamic Programming and Reinforcement Learning (ADPRL-09) (2009)

We propose an approach for inferring bounds on the finite-horizon return of a control policy from an off-policy sample of trajectories collecting state transitions, rewards, and control actions. In this ... [more ▼]

We propose an approach for inferring bounds on the finite-horizon return of a control policy from an off-policy sample of trajectories collecting state transitions, rewards, and control actions. In this paper, the dynamics, control policy, and reward function are supposed to be deterministic and Lipschitz continuous. Under these assumptions, a polynomial algorithm, in terms of the sample size and length of the optimization horizon, is derived to compute these bounds, and their tightness is characterized in terms of the sample density. [less ▲]

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See detailRecovery of ionic liquids in tailor-made fuel process
Abels, Christian; Melin, Thomas; Kröckel, Jan et al

Conference (2009)

Extraction and membrane process can be useful for the separation of ionic liquid from impurities. The partition coefficient of model compounds between ionic liquid and organic phase was determined at ... [more ▼]

Extraction and membrane process can be useful for the separation of ionic liquid from impurities. The partition coefficient of model compounds between ionic liquid and organic phase was determined at various conditions. The principal effect of high viscosity on extraction behaviour was estimated with polyethyle glycol in water. Different nanofiltration membranes were screened for the stability towards ionic liquids and for the separation of water from ionic liquids. [less ▲]

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See detailTargeted energy transfer for suppressing aeroelastic instability due to unsteady lift
Lee, Y. S.; Vakakis, Alexander F.; Bergman, L. A. et al

in Targeted energy transfer for suppressing aeroelastic instability due to unsteady lift, Palm Springs, 2009 (2009)

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See detailL'hypnose dans la prise en charge des douleurs chroniques
Zelinka, V.; Faymonville, Marie-Elisabeth ULg; Pitchot, William ULg et al

in Acta Psychiatrica Belgica (2009), 109(3), 21-28

OUR REVIEW OF THE LITERATURE SUGGESTSTHAT HYPNOSIS IS AN USEFUL OPTION lN THE MANAGEMENT OF CHRONIC PAIN.THE EXPLANATIONS FOR ITS EFFECTIVENESS RELIE MAINLY ON THE FINDINGS OF FUNCTIONAL NEUROIMAGING ... [more ▼]

OUR REVIEW OF THE LITERATURE SUGGESTSTHAT HYPNOSIS IS AN USEFUL OPTION lN THE MANAGEMENT OF CHRONIC PAIN.THE EXPLANATIONS FOR ITS EFFECTIVENESS RELIE MAINLY ON THE FINDINGS OF FUNCTIONAL NEUROIMAGING, CLINICAL STUDIES AND EMPIRICAL OBSERVATIONS. THESE DATA SHOWTHAT THROUGH THE DIVERSITY OF ITS EFFECTS, HYPNOSIS CAN MODULATE THE BIO-PSYCHO-SOCIAL DIMENSIONS OF CHRONIC PAIN. THE CHOICE OF THIS THERAPEUTIC TECHNIQUE SHOULD BE GUIDED BY THE ESTIMATE OF ITS USEFULNESS. THE EFFICACY IS ASSESSED ON AN INDIVIDUAL BASIS, TAKING INTO ACCOUNT THE BENEFITS AND LIMITATIONS OF HYPNOSIS FOR EACH PATIENT. [less ▲]

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See detailLe Code des sociétés annoté
Caprasse, Olivier ULg

Book published by La Charte (2009)

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See detailNeed for high-standard translation methodology for the dissemination of guidelines.
Henrotin, Yves ULg

in Osteoarthritis and Cartilage (2009), 17(12), 1536-8

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