References of "2009"
     in
Bookmark and Share    
Full Text
See detailOptimiser une prise de décision fondée sur la preuve scientifique
Vandeweerd, Jean-Michel ULg; Vandenput, Sandrina ULg

in Point Vétérinaire (2009), 40(298), 37-40

les deux premières étapes de la démarche de la médecine factuelle sont la formulation correcte de la question posée et l'élaboration précise de la requête dans les bases de données bibliographiques

Detailed reference viewed: 50 (13 ULg)
Full Text
Peer Reviewed
See detailCardiovascular Responses to Static Assessments of Trunk Muscles
Demoulin, Christophe ULg; Grosdent, Stéphanie ULg; Bury, Thierry ULg et al

in Journal of Musculoskeletal Pain (2009), 17(4), 378-389

Objectives: To investigate the cardiovascular responses to standard static assessments of strength and endurance of trunk extensor muscles. Methods: Trunk extensor performances of ten healthy men, 48.2±5 ... [more ▼]

Objectives: To investigate the cardiovascular responses to standard static assessments of strength and endurance of trunk extensor muscles. Methods: Trunk extensor performances of ten healthy men, 48.2±5.6 years, and 10 healthy women, 49±5.7 years, were assessed by means of a maximum static strength test [consisting in maximal voluntary contractions [MVC] performed with a specific dynamometer], and two static endurance tests [the Sorensen test, and a 50 percent MVC test]. Heart rate [HR], auscultatory systolic [SBP], and diastolic blood pressure [DBP] were recorded throughout the tests. Results: The MVCs induced significant increases of HR and SBP [mean peak values averaging 90 [female] to 95 [male] beats per minute and 133 [female] to 141 [male] mmHg]. The HR, SBP, and DBP values increased significantly across time throughout both endurance static tests. At the end of these tests, mean HR, SBP, and DBP reached 114 to 122 beats per minute, 172 to 185 mmHg, and 112 to 120 mmHg. Genders differed significantly with regard to holding times [longer in females], but a gender effect was only found on SBP [higher in males]. Heart rate and SBP increases were significantly higher in males than in female subjects. Conclusions: The strength test seems less demanding than expected, though our results need to be confirmed. Standard static endurance tests yield sizeable functional stress on the cardiovascular system. Our study emphasizes the need to exclude subjects with cardiac trouble from such efforts and suggests the relevance of monitoring cardiovascular parameters if tests are performed until exhaustion. [less ▲]

Detailed reference viewed: 110 (28 ULg)
See detailLa tutelle sur les marchés publics en Région wallonne
Durviaux, Ann-Lawrence ULg

Conference given outside the academic context (2009)

Detailed reference viewed: 21 (4 ULg)
Full Text
Peer Reviewed
See detailChaotic bouncing of a droplet on a soap film
Gilet, Tristan ULg; Bush, John, W.M.

in Physical Review Letters (2009), 102

We examine the complex dynamics arising when a water droplet bounces on a horizontal soap film suspended on a vertically oscillating circular frame. A variety of simple and complex periodic bouncing ... [more ▼]

We examine the complex dynamics arising when a water droplet bounces on a horizontal soap film suspended on a vertically oscillating circular frame. A variety of simple and complex periodic bouncing states are observed, in addition to multiperiodicity and period-doubling transitions to chaos. The system is simply and accurately modeled by a single ordinary differential equation, the numerical solution of which captures all the essential features of the observed behavior. Iterative maps and bifurcation diagrams indicate that the system exhibits all the features of a classic low-dimensional chaotic oscillator. [less ▲]

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailLes linguistes et leurs graphiques. Introduction
Badir, Sémir ULg

in Cahiers Parisiens = Parisian Notebooks (2009), 5

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailSubjective evaluation of the long-term efficacy of speech therapy on dysfunctional dysphonia.
Morsomme, Dominique ULg; Faurichon de la Bardonnie, Marie; Verduyckt, Ingrid et al

in Journal of Voice (2009)

The objective of the study was to measure the subjective long-term effects of vocal therapy (more than 6 months) in 29 patients suffering from dysfunctional dysphonia. Four subjective measurements were ... [more ▼]

The objective of the study was to measure the subjective long-term effects of vocal therapy (more than 6 months) in 29 patients suffering from dysfunctional dysphonia. Four subjective measurements were used: one visual analog scale ranging from 0 (not efficient at all) to 100 (very efficient); one question "Is the speech therapy still efficient?," answered by yes or no; the GRB parameters of the GRBAS scale (evaluated by the patient); and the VHI-10. The results show that 76% of the patients consider that the vocal therapy they received is still efficient. On the vocal quality (G), roughness (R), and breathiness (B) parameters, we observe a high degree of satisfaction on the G parameter (median=77). The scores on the R and B parameters are lower (median R=12, S=5). Roughness is significantly correlated to the Grade (Spearman coefficient r=0.516, P=0.004), whereas breathiness is not (P=0.251, NS). The comparison of the results on the VHI-10 pre and post treatment shows a significant decrease in the grade of perceived handicap (medians 15 vs 11, P=0.017). The correlations between the judgment of the treatment's efficacy and the vocal quality is significant (r=0.623, P<0.001) as well as the correlation between the VHI-10 and the length of the treatment (r=0.416, P=0.035). The conclusion can be made that speech therapy plays an important role in long-term treatment of dysfunctional dysphonias. [less ▲]

Detailed reference viewed: 46 (6 ULg)
Peer Reviewed
See detailEvaluation of the long-term barrier effect of commercial resorbable guided tissue regenerative membranes : an in vitro study using human gingival fibroblasts
Grenade, Charlotte ULg; Borget, Pascal; Moniotte, Nicolas et al

Poster (2009)

Introduction The first part of the study devoted to guided tissue regenerative membranes was focused on a better understanding of the physicochemical and mechanical properties of commercial materials. The ... [more ▼]

Introduction The first part of the study devoted to guided tissue regenerative membranes was focused on a better understanding of the physicochemical and mechanical properties of commercial materials. The second objective of our study was to develop an in vitro device able to measure the long-term barrier effect of resorbable membranes. After the development of this new device, experiments were realized to characterize the long-term behaviour of commercially membranes with human gingival fibroblasts (HGF). Materials and methods The use of human gingival fibroblastic cells was chosen to get closer to biological conditions. Some gingival explants were removed in young and non-smoking healthy patients. From these explants, fibroblastic cells were isolated and cultivated. These cells will be able to be used between the third and the sixth passage. Resorbable membranes were chosen because they don’t require a second surgical operation. There are made of polyesters or collagen. A system based on inserts was developed in order to follow the degradation of membranes and the migration of cells across the material. The membrane was cut into 8 mm diameter punches and set in the bottom of the system. Once the whole was put together, it is laced into a 12 wells plate culture. First, the plates were put in an incubator at 37°C, during times ranging from 24 hours to several months. The barrier effect was then measured to reflect the gradual increase of permeability of each membrane. For this purpose, HGF were seeded on the different samples. The top of the bottle and the bottom of the well were then filled with culture medium. Non degradable synthetic Bioflex membranes were chosen as control samples which don't let pass cells (porosity : 0,4 µm). After 48 hours of incubation in the presence of cells, pictures of cells on membranes and in the bottom of wells were taken with an optic microscope. Viability tests (MTS) were then realized on membranes to evaluate cells proliferation and in the bottom of wells to measure barrier effect. Finally, the morphology of cells on selected membranes was characterized by Scanning Electron Microscopy. Conclusion Proliferation results correspond to data published by several authors. Furthermore, the barrier effect times found in the present study are similar to barrier effect times demonstrated in in vivo studies and announced by manufacturers. In conclusion, the finalized system is adapted to the analysis of long-term barrier effect of commercial GTR membranes. This system will be tested with synthetic bioresorbable membranes made of copolymers. [less ▲]

Detailed reference viewed: 87 (9 ULg)
Full Text
Peer Reviewed
See detailNonlinear normal modes, Part 1: Useful framework for the structural dynamicist
Kerschen, Gaëtan ULg; Peeters, Maxime ULg; Golinval, Jean-Claude ULg et al

in Mechanical Systems & Signal Processing (2009), 23

The conceptofnonlinearnormalmodes(NNMs)isdiscussedinthepresentpaperandits companion,PartII.BecausethereisvirtuallynoapplicationoftheNNMstolarge-scale engineeringstructures ... [more ▼]

The conceptofnonlinearnormalmodes(NNMs)isdiscussedinthepresentpaperandits companion,PartII.BecausethereisvirtuallynoapplicationoftheNNMstolarge-scale engineeringstructures,thesepapersareanattempttohighlightseveralaspectsthat mightdrivetheirdevelopmentinthefuture.Specifically,wesupportthat(i)numerical methodsforthecontinuationofperiodicsolutionspavethewayforaneffectiveand practical computationofNNMs,and(ii)time–frequencyanalysisisparticularlysuitable fortheanalysisoftheresultingdynamics.Anotherobjectiveofthepresentpaperisto describe,insimpleterms,andtoillustratethefundamentalpropertiesofNNMs.Thisis achievedtoconvincethestructuraldynamicistnotnecessarilyacquaintedwiththemthat theyareausefulframeworkfortheanalysisofnonlinearvibratingstructures. & 2008ElsevierLtd.Allrightsreserved [less ▲]

Detailed reference viewed: 144 (28 ULg)
Full Text
Peer Reviewed
See detailEdgetic perturbation models of human inherited disorders.
Zhong, Quan; Simonis, Nicolas; Li, Qian*-Ru et al

in Molecular Systems Biology (2009), 5

Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as 'nodes' and 'edges ... [more ▼]

Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as 'nodes' and 'edges', respectively. Better understanding of genotype-to-phenotype relationships in human disease will require modeling of how disease-causing mutations affect systems or interactome properties. Here we investigate how perturbations of interactome networks may differ between complete loss of gene products ('node removal') and interaction-specific or edge-specific ('edgetic') alterations. Global computational analyses of approximately 50,000 known causative mutations in human Mendelian disorders revealed clear separations of mutations probably corresponding to those of node removal versus edgetic perturbations. Experimental characterization of mutant alleles in various disorders identified diverse edgetic interaction profiles of mutant proteins, which correlated with distinct structural properties of disease proteins and disease mechanisms. Edgetic perturbations seem to confer distinct functional consequences from node removal because a large fraction of cases in which a single gene is linked to multiple disorders can be modeled by distinguishing edgetic network perturbations. Edgetic network perturbation models might improve both the understanding of dissemination of disease alleles in human populations and the development of molecular therapeutic strategies. [less ▲]

Detailed reference viewed: 77 (8 ULg)
Full Text
Peer Reviewed
See detailA nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Angus cattle.
Koltes, James E; Mishra, Bishnu P; Kumar, Dinesh et al

in Proceedings of the National Academy of Sciences of the United States of America (2009), 106(46), 19250-5

Historically, dwarfism was the major genetic defect in U.S. beef cattle. Aggressive culling and sire testing were used to minimize its prevalence; however, neither of these practices can eliminate a ... [more ▼]

Historically, dwarfism was the major genetic defect in U.S. beef cattle. Aggressive culling and sire testing were used to minimize its prevalence; however, neither of these practices can eliminate a recessive genetic defect. We assembled a 4-generation pedigree to identify the mutation underlying dwarfism in American Angus cattle. An adaptation of the Elston-Steward algorithm was used to overcome small pedigree size and missing genotypes. The dwarfism locus was fine-mapped to BTA6 between markers AFR227 and BM4311. Four candidate genes were sequenced, revealing a nonsense mutation in exon 15 of cGMP-dependant type II protein kinase (PRKG2). This C/T transition introduced a stop codon (R678X) that truncated 85 C-terminal amino acids, including a large portion of the kinase domain. Of the 75 mutations discovered in this region, only this mutation was 100% concordant with the recessive pattern of inheritance in affected and carrier individuals (log of odds score = 6.63). Previous research has shown that PRKG2 regulates SRY (sex-determining region Y) box 9 (SOX9)-mediated transcription of collagen 2 (COL2). We evaluated the ability of wild-type (WT) or R678X PRKG2 to regulate COL2 expression in cell culture. Real-time PCR results confirmed that COL2 is overexpressed in cells that overexpressed R678X PRKG2 as compared with WT PRKG2. Furthermore, COL2 and COL10 mRNA expression was increased in dwarf cattle compared with unaffected cattle. These experiments indicate that the R678X mutation is functional, resulting in a loss of PRKG2 regulation of COL2 and COL10 mRNA expression. Therefore, we present PRKG2 R678X as a causative mutation for dwarfism cattle. [less ▲]

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailOperational Families of Entanglement Classes for Symmetric N-Qubit States
Bastin, Thierry ULg; Krins, Stéphanie ULg; Mathonet, Pierre ULg et al

in Physical Review Letters (2009), 103

We solve the entanglement classification under stochastic local operations and classical communication (SLOCC) for all multipartite symmetric states in the general N-qubit case. For this purpose, we ... [more ▼]

We solve the entanglement classification under stochastic local operations and classical communication (SLOCC) for all multipartite symmetric states in the general N-qubit case. For this purpose, we introduce 2 parameters playing a crucial role, namely, the diversity degree and the degeneracy configuration of a symmetric state. Those parameters give rise to a simple method of identifying operational families of SLOCC entanglement classes of all symmetric N-qubit states, where the number of families grows as the partition function of the number of qubits. [less ▲]

Detailed reference viewed: 43 (8 ULg)
Full Text
Peer Reviewed
See detailComment investiguer la contre-performance d’origine médicale : de la clinique au laboratoire
Richard, Eric; Pitel, P. H.; Fortier, G. et al

in 35ème Journée de la Recherche équine (2009)

Clinical affections of the locomotor and respiratory systems are the two main causes of poor performance in sport horses. Nevertheless, each subclinical affection of any system implicated in the oxygen ... [more ▼]

Clinical affections of the locomotor and respiratory systems are the two main causes of poor performance in sport horses. Nevertheless, each subclinical affection of any system implicated in the oxygen system (respiratory, cardiovascular, blood, muscular and metabolic) may also become a limiting factor concerning the athletic capacities of the horse. A systematic medical examination of the horse, combining ail the clinical and laboratory exams, is thus necessary in order to establish a precise and comprehensive diagnosis regarding the different affections. The objectives of this communication are therefore to present the different methods currently available for the practitioner as well as the techniques recently developed for horses. The complementarity of the different clinical and laboratory exams, as well as the ideal moment for performing each test are clarified in order to accurately determine the different causes of poor performance as well as their functional repercussions [less ▲]

Detailed reference viewed: 88 (6 ULg)
Full Text
Peer Reviewed
See detailStructural, Magnetic and Mössbauer Spectral Study of the Electronic Spin-state Transition in {Fe[HC(3-Mepz)2(5-Mepz)]2}(BF4)2
Reger, Daniel; Elgin, J.; Foley, E. et al

in Inorganic Chemistry (2009), 48

The complex {Fe[HC(3-Mepz)2(5-Mepz)]2}(BF4)2 (pz = pyrazolyl ring) has been prepared by the reaction of HC(3-Mepz)2(5-Mepz) with Fe(BF4)2·6H2O. The solid state structures obtained at 294 and 150 K show a ... [more ▼]

The complex {Fe[HC(3-Mepz)2(5-Mepz)]2}(BF4)2 (pz = pyrazolyl ring) has been prepared by the reaction of HC(3-Mepz)2(5-Mepz) with Fe(BF4)2·6H2O. The solid state structures obtained at 294 and 150 K show a distorted iron(II) octahedral N6 coordination environment with the largest deviations arising from the restrictions imposed by the chelate rings. At 294 K the complex is predominately high-spin with Fe–N bond distances averaging 2.14 Å, distances that are somewhat shorter than expected for a purely high-spin iron(II) complex because of the presence of an admixture of ca. 70 (I get 80 from both mag and X-ray, 3/15, where 3 is the subtraction of 2.14 and 2.17 and 15 1.99 and 2.14 and from Figure 3b) percent high-spin and 30 (20) percent low-spin iron(II). At 294 K the twisting of the pyrazolyl rings from the ideal C3v symmetry averages only 2.2o, a much smaller twist than has been observed previously in similar complexes. At 150 K the Fe–N bond distances average 1.99 Å, indicative of an almost fully low-spin iron(II) complex; the twist angle is only 1.3o, as expected for a complex with these Fe–N bond distances. The magnetic properties show that the complex undergoes a gradual change from low-spin iron(II) below 85 K to high-spin iron(II) at 400 K. The 4.2 to 60 K Mössbauer spectra correspond to a fully low-spin iron(II) complex but, upon further warming, the iron(II) begins to undergo spin-state relaxation on the Mössbauer time scale such that, at 155 and 315 K, the complex is 7.5 and 65 percent high-spin in the absence of any adjustment for the differing low-spin and high-spin recoil-free fractions. I would replace the previous sentence with the red. I see no reason to give the % from the Mössbauer in the abstract as it is likely a bit low as discussed in detail – neither the mag data nor X-ray data have the recoil issue. The last sentence in the abstract is the key information. OK The 4.2 to 60 K Mössbauer spectra correspond to a fully low-spin-iron(II) complex but, upon further warming above 85 K the iron(II) begins to undergo spin-state relaxation between the low- and high-spin forms on the Mössbauer time scale. At 155 and 315 K the complex exhibits spin-state relaxation rates of 0.36 and 7.38 MHz, respectively, and an Arrhenius plot of the logarithm of the relaxation rate yields an activation energy of 670 ± 40 cm–1 for the spin-state relaxation. [less ▲]

Detailed reference viewed: 16 (0 ULg)
Full Text
See detailConcentrations of pregnancy-associated glycoproteins in Water buffaloes females (Bubalus bubalis) during pregnancy and postpartum periods
Barbato, O.; Melo de Sousa, Noelita ULg; Malfatti, A. et al

in O’Leary, M.; Arnett, J. (Eds.) Pregnancy Protein Research (2009)

The concentrations of pregnancy-associated glycoproteins (PAG) were determined in buffalo cows (Bubalus bubalis) using three different radioimmunoassay (RIA) systems (RIA-497, RIA-706, and RIA-708 ... [more ▼]

The concentrations of pregnancy-associated glycoproteins (PAG) were determined in buffalo cows (Bubalus bubalis) using three different radioimmunoassay (RIA) systems (RIA-497, RIA-706, and RIA-708). Samples (10 mL) were collected by jugular venipuncture from Week 0 until Week 28 of pregnancy (9 females), and from parturition until Week 10 postpartum (13 females). During pregnancy, PAG molecules were detectable at Week 6 using the three aforementioned RIA systems (3.9 ± 1.3 ng/mL, 9.7 ± 1.3 ng/mL, and 9.9 ± 0.7 ng/mL for RIA-497, RIA-706, and RIA-708, respectively). These concentrations increased gradually until Week 28, reaching values of 39.6 ± 4.0 ng/mL (RIA-497), 50.5 ± 11.9 ng/mL (RIA-706), and 68.2 ± 20.8 ng/mL (RIA-708). PAG concentrations determined by RIA-497, RIA-706, and RIA-708 were strongly correlated throughout the entire gestation period, RIA-708 giving the higher concentrations. At parturition, the mean concentrations ranged from 34.9 ± 4.0 (RIA-497) to 84.7 ± 10.6 ng/mL (RIA-708). Thereafter, the concentrations decreased steadily, reaching very low levels (< 1.0 ng/mL) at Week 8 postpartum. In conclusion, PAG concentrations measured by the above three RIA systems showed a profile similar to those previously described in bovine species, with higher concentrations being detected by RIA-706 and RIA-708. However, the patterns of PAG concentrations, studied using the three aforementioned PAG-RIA systems, differed around parturition, with very low levels being observed in the female buffaloes [less ▲]

Detailed reference viewed: 94 (4 ULg)
See detailAssessment of modelling uncertainties in long-term climate and sea level change projections "Aster"
Fichefet, T.; Loutre, M.-F.; Goosse, H. et al

Report (2009)

Detailed reference viewed: 18 (4 ULg)
Full Text
See detailDe l’équité dans l’adaptation aux impacts du changement climatique
Gemenne, François ULg

in Cournil, Christel; Colard-Fabregoule, Catherine (Eds.) Changements climatiques et défis du droit (2009)

Detailed reference viewed: 12 (0 ULg)
Full Text
See detailLa jurisprudence de la Cour au prisme de la science économique
Sibony, Anne-Lise ULg

in Mbongo, Pascal; Vauchez, Antoine (Eds.) Dans la fabrique du droit européen : Scènes, acteurs et publics de la Cour de justice des Communautés européennes (2009)

The European Court of justice has long been aware of economists watching its judgements, particularly in the field of European Competition Law. This article considers first what exactly economists are ... [more ▼]

The European Court of justice has long been aware of economists watching its judgements, particularly in the field of European Competition Law. This article considers first what exactly economists are looking at when they read the case law. Then, the typical content of their observation is analysed. Finally, the analysis turns to how the Court takes into account economist's view point on the case law. [less ▲]

Detailed reference viewed: 134 (6 ULg)
Peer Reviewed
See detailL'efficacité de l'ibandronate oral mensuel est maintenue sur 5 ans : l'étude MOBILE extension long terme (ELT)
Chapurlat, R.; Felsenberg, F.; Reginster, Jean-Yves ULg

in Revue du Rhumatisme (2009)

Detailed reference viewed: 8 (2 ULg)
See detailTroubles de la rétention à court terme
Majerus, Steve ULg; Poncelet, Martine ULg

in Poncelet, Martine; Majerus, Steve; Van der Linden, Martial (Eds.) Traité de Neuropsychologie de l'Enfant (2009)

Detailed reference viewed: 69 (12 ULg)