References of "2009"
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See detailTe Visioscan driven ULEV and SELS methods
QUATRESOOZ, Pascale ULg; PIERARD, Gérald ULg

in Handbook of cosmetic science and technology (2009)

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See detailInformation du patient lombalgique : de la recherche à la pratique
Marty, Marc; Henrotin, Yves ULg

in Revue du Rhumatisme (2009), 76

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See detailLes cas cliniques, une vision panachee de la medecine: de la simple anecdote a l'enseignement pratique.
Lefebvre, Pierre ULg; Scheen, André ULg

in Revue Médicale de Liège (2009), 64(7-8), 357

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See detailAcid-base status and hemodynamic stability during propofol and sevoflurane-based anesthesia in patients undergoing uncomplicated intracranial surgery.
Bonhomme, Vincent ULg; Demoitie, Jeannick ULg; Schaub, Isabelle ULg et al

in Journal of Neurosurgical Anesthesiology (2009), 21(2), 112-9

Propofol anesthesia may induce metabolic disturbances and sevoflurane anesthesia arterial hypotension. This study compares both techniques regarding acid-base and hemodynamic status during intracranial ... [more ▼]

Propofol anesthesia may induce metabolic disturbances and sevoflurane anesthesia arterial hypotension. This study compares both techniques regarding acid-base and hemodynamic status during intracranial surgery. Sixty-one patients were randomized into 2 groups according to anesthesia maintenance, a propofol group (n=30), and a sevoflurane group (n=31). The anesthesia protocol including rocuronium and remifentanil infusion was otherwise similar in both groups. Arterial blood samples were drawn every 2 hours during the procedure and upon arrival in the intensive care unit to assess acid-base status. The number of hypotensive and hypertensive events served to assess hemodynamic stability. Metabolic acidosis was more frequent during propofol than sevoflurane anesthesia (7 out of 29 and 1 out of 31, P=0.02). Its severity was linearly correlated with lactate concentration (R=0.32), total dose of propofol (R=0.2), and length of procedure (R=0.28). Hyperlactacidemia was also observed during sevoflurane anesthesia, but without acidosis. Hypertension occurred more frequently during propofol than sevoflurane anesthesia (13 out of 30 vs. 1 out of 31, P<0.001), particularly in patients with a past medical history of hypertension. Higher remifentanil infusion rates reduced the risk of hypertension. Conversely, sevoflurane anesthesia favored arterial hypotension (22 out of 31 vs. 12 out of 30, P=0.015). Preoperative morning administration of antihypertensive medications to patients with a history of arterial hypertension was associated with a low probability of hypertensive events, at the cost of more frequent hypotension. In conclusion, propofol anesthesia for intracranial surgery is more frequently associated with lactic acidosis and hypertension; sevoflurane anesthesia may favor arterial hypotension. [less ▲]

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See detailBIOLOGIE MOLECULAIRE APPLIQUEE A L’HOMME
Noël, Agnès ULg

Learning material (2009)

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See detailPolitologie africaine: quelle spécificité pour l'avenir?
Kabamba, Bob ULg

in Revue de la Faculté de Droit de l'Université de Liège (2009)

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See detailPartager des corpus et leurs analyses à l'heure du Web 2.0
Bénel, Aurélien; Lejeune, Christophe ULg

in Degrés : Revue de Synthèses à Orientation Sémiologique (2009), 36-37(136-137), 1-20

En se focalisant sur les documents, l'interprétation et l'intersubjectivité, les technologies du Web 2.0 présentent de surprenantes analogies avec l'herméneutique philosophique, théorie de l ... [more ▼]

En se focalisant sur les documents, l'interprétation et l'intersubjectivité, les technologies du Web 2.0 présentent de surprenantes analogies avec l'herméneutique philosophique, théorie de l'interprétation des textes. L'herméneutique philosophique fut obtenue par généralisation de l'herméneutique biblique par Dilthey au XIXe siècle pour être choisie comme alternative au positivisme dans la fondation de l'épistémologie et des méthodes des sciences de l'homme et de la société. Le présent article tente de montrer en quoi les technologies du Web 2.0 semblent plus adaptées aux besoins des sciences de l'homme et de la société que l'informatique traditionnelle, historiquement liée au positivisme logique. Des illustrations sont fournies en archéologie et en sociologie, deux disciplines qui furent des précurseurs dans l'utilisation de la mécanographie et des ordinateurs. [less ▲]

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See detailEtude hydrologique et hydrodynamique du bassin versant de la Berwinne
Archambeau, Pierre ULg; Khuat Duy, Bruno; Pirotton, Michel ULg

Report (2009)

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See detailAntibiotic prescribing in dental practice in Belgium.
Mainjot, Amélie ULg; D'Hoore, W.; Van Heusden, Alain ULg et al

in International Endodontic Journal (2009), 42(12), 1112-7

AIM: To assess the types and frequency of antibiotic prescriptions by Belgian dentists, the indications for antibiotic prescription, and dentists' knowledge about recommended practice in antibiotic use ... [more ▼]

AIM: To assess the types and frequency of antibiotic prescriptions by Belgian dentists, the indications for antibiotic prescription, and dentists' knowledge about recommended practice in antibiotic use. METHODOLOGY: In this cross-sectional survey, dental practitioners were asked to record information about all antibiotics prescribed to their patients during a 2-week period. The dental practitioners were also asked to complete a self-administered questionnaire regarding demographic data, prescribing practices, and knowledge about antibiotic use. A random sample of 268 Belgian dentists participated in the survey. RESULTS: During the 2-week period, 24 421 patient encounters were recorded; 1033 patients were prescribed an antibiotic (4.2%). The median number of prescriptions per dentist for the 2 weeks was 3. Broad spectrum antibiotics were most commonly prescribed: 82% of all prescriptions were for amoxycillin, amoxycillin-clavulanic acid and clindamycin. Antibiotics were often prescribed in the absence of fever (92.2%) and without any local treatment (54.2%). The most frequent diagnosis for which antibiotics were prescribed was periapical abscess (51.9%). Antibiotics were prescribed to 63.3% of patients with periapical abscess and 4.3% of patients with pulpitis. Patterns of prescriptions were confirmed by the data from the self-reported practice. CONCLUSIONS: Discrepancies between observed and recommended practice support the need for educational initiatives to promote rational use of antibiotics in dentistry in Belgium. [less ▲]

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See detailDes dépendances qui nous enchainent aux liens qui nous déchainent
Farbos, Julie; Servais, Catherine; Noirfalise, Stéphanie et al

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2009), 11

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See detailFORMULATION OF PEPTIDE-LOADED LIPOSOMES FOR INTRAVENOUS DELIVERY: OPTIMIZATION OF THE ENCAPSULATION EFFICIENCY
Ducat, Emilie ULg; Brion, Michael; Evrard, Brigitte ULg et al

Conference (2009)

Purpose: Print 3G is a peptidic antagonist of oncoprotein involved in breast cancer, containing 25 amino acids. The purpose of this work is to study the peptide encapsulation into PEGylated liposomes ... [more ▼]

Purpose: Print 3G is a peptidic antagonist of oncoprotein involved in breast cancer, containing 25 amino acids. The purpose of this work is to study the peptide encapsulation into PEGylated liposomes composed of SPC:CHOL:mPEG-2000-DSPE (47:47:6). Methods: Loaded unilamellar vesicles were prepared by hydration of lipid film method. Unfortunately, a loss of Print 3G was observed during the different steps of this manufacturing technique giving rise to encapsulation efficiencies (EE) close to 0 %. Thus, the freeze-thawing method was used to enhance the amount of Print 3G encapsulated into blank liposomes prepared using the above procedure. Because many factors may influence the peptide entrapment into the vesicles (number of freeze-thawing cycles (NC), lipid concentration (LC), peptide concentration (PC) and mixing time (MT)), a design of experiment (DOE) was performed (for the screening, a Plackett and Burman plan; for the optimization, a central composite design). EE were calculated in terms of quantity of peptide loaded in liposomes as a function of quantity operated (EEp) or quantity of lipids (EEl). Results: The EE obtained by the freeze-thawing method in standard conditions (Katanasaka, Ida et al., 2008; Maeda, Bharate et al., 2008), amounted to 26.20 ± 7.98 %, n=3 (EEp) and to 0.26 ± 0.074 % (EEl). Among the different considered parameters, the screening permitted to identify two factors having a positive and significant influence on the EE: NC and LC. Concerning the PC and MT, no influence was revealed. For the second part of the DOE, the positive factors were optimized and obtained results revealed a theoretical optimum at 64.75 ± 3.55 % when 11 freeze-thawing cycles were applied (NC) and for the following LC: 36.1 mM SPC, 36.1 mM CHOL and 4mM mPEG-2000-DSPE. The experimental results showed an encapsulation efficiency of 62.68 ± 2.93 %. Photon correlation spectroscopy and freeze-fracture electron microscopy were also realized to examine the liposome integrity, before and after the freeze-thawing cycles. Conclusion: Changing the manufacturing technique permitted a significant encapsulation of Print 3G into liposomes. The DOE led to a significant improvement of encapsulation efficiencies. References: (1) Katanasaka,Y., Ida,T., Asai,T., Maeda,N., Oku,N., 2008. Effective delivery of an angiogenesis inhibitor by neovessel-targeted liposomes. International Journal of Pharmaceutics, 360, 219-224. (2) Maeda,H., Bharate,G.Y., Daruwalla,J., 2008. Polymeric drugs for efficient tumor-targeted drug delivery based on EPR effect. Eur. J Pharm Biopharm. Acknowledgements: This work was supported by the Ministry of the Walloon Region. [less ▲]

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See detailCHARACTERIZATION AND OPTIMIZATION OF PEPTIDE ENCAPSULATION IN PEGYLATED LIPOSOMES
Ducat, Emilie ULg; Brion, Michael; Evrard, Brigitte ULg et al

Poster (2009)

Purpose: Print 3G is a peptidic antagonist of oncoprotein involved in breast cancer, containing 25 amino acids. The purpose of this work is to study the peptide encapsulation into PEGylated liposomes. Two ... [more ▼]

Purpose: Print 3G is a peptidic antagonist of oncoprotein involved in breast cancer, containing 25 amino acids. The purpose of this work is to study the peptide encapsulation into PEGylated liposomes. Two formulations composed of SPC:CHOL:mPEG-750-DSPE (47:47:6) or SPC:CHOL:mPEG-2000-DSPE (47:47:6) were investigated. Methods: Unilamellar vesicles containing either mPEG750 or mPEG2000 were prepared by hydration of lipid films method. Unfortunately, a loss of Print 3G was observed during the different steps of this manufacturing technique giving rise to encapsulation efficiencies close to 0 %. Thus, the freeze-thawing method was used to enhance the amount of Print 3G encapsulated into blank liposomes prepared using the above procedure. Because many factors may influence the peptide entrapment into the vesicles (number of freeze-thawing cycles, lipid concentration, peptide concentration, mixing time and liposome composition), a design of experiment was performed (for the screening, a Plackett and Burman plan; for the optimization, a central composite design). Results: The encapsulation efficiencies obtained by the freeze-thawing method in standard conditions, varied between 17.26 ± 0.46 % (n=3) for liposomes containing mPEG750 and 26.20 ± 7.98 % (n=3) for those comprising mPEG2000. Among the different considered factors, the screening permitted to identify two factors having a positive and significant influence on the encapsulation efficiencies: the number of freeze-thawing cycles and the lipid concentration, while the presence of mPEG2000 or mPEG750 had a relatively weak effect on the encapsulation. Concerning the peptide concentration and the mixing time, no influence was revealed. For the second part of the DOE, the positive factors were optimized for the liposomes containing mPEG2000. The obtained results for liposomes containing mPEG2000 revealed a theoretical optimum at 64.75 ± 3.55 % when 11 freeze-thawing cycles were applied and for the following lipid concentrations: 36.1 mM SPC, 36.1 mM CHOL and 4mM mPEG-2000-DSPE. The experimental results showed an encapsulation efficiency of 62.68 ± 2.93 %. Conclusion: Changing the manufacturing technique permitted a significant encapsulation of Print 3G into liposomes. The DOE led to a significant improvement of encapsulation efficiencies for the liposomes containing mPEG2000. Thereafter, an optimization design for liposomes containing mPEG750 will be started. Acknowledgements: This work was supported by the Ministry of the Walloon Region. [less ▲]

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See detailSlope stability analyses in loess deposits in Fergana Valley (Kyrgyzstan)
Mamyrova, Raushan; Bourdeau, Céline; Havenith, Hans-Balder ULg et al

Conference (2009)

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See detailCompte-rendu de l'ouvrage de Laurent BRICAULT (dir.), 'Bibliotheca Isiaca I', Bordeaux, Éditions Ausonius, 2008.
Puccio, Laetizia ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (2009), 22

Ce premier volume de la Bibliotheca Isiaca inaugure une nouvelle collection consacrée aux études isiaques et plus largement aux relations entre l’Égypte et le reste du monde gréco-romain. Sans prétendre à ... [more ▼]

Ce premier volume de la Bibliotheca Isiaca inaugure une nouvelle collection consacrée aux études isiaques et plus largement aux relations entre l’Égypte et le reste du monde gréco-romain. Sans prétendre à l’exhaustivité, son directeur, Laurent Bricault, professeur d’histoire romaine à l’Université de Toulouse II-Le Mirail, y exprime clairement le souhait de réunir toutes les nouveautés dans ce domaine. Mieux encore, face à la multiplication des découvertes et des travaux relatifs au sujet, la série Bibliotheca Isiaca se veut un outil de travail actualisé, scientifique et utile à la fois pour le chercheur, l’enseignant et l’étudiant. [less ▲]

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See detailLa P.E.B. expliquée
Delnoy, Michel ULg

in Delnoy, Michel; Hauglustaine, Jean-Marie; Levaux, Jean-Baptiste (Eds.) La P.E.B. expliquée (2009)

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See detailUncertainty of carbon dioxide fluxes introduced by different high-pass filtering methods
Ibrom, Andreas; Geißler, Simon; Laffineur, Quentin ULg et al

Conference (2009)

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See detailLa sanction des irrégularités procédurales
Georges, Frédéric ULg; de Leval, Georges ULg

in Lecocq, Pascale (Ed.) Chronique de droit à l'usage des juges de paix et de police 2009 (2009)

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See detailAnalyse des modalités d'utilisation d'un distributeur automatique de concentré (DAC) par des truies gestantes logées en groupe dynamique
Wavreille, José; Remience, Virginie; Canart, Bernard et al

in 41èmes Journées de la Recherche porcine (2009)

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