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See detail(1)H, (13)C and (15)N assignments of a camelid nanobody directed against human alpha-synuclein.
Vuchelen, Anneleen; O'Day, Elizabeth; De Genst, Erwin et al

in Biomolecular NMR Assignments (2009), 3(2), 231-3

Nanobodies are single chain antibodies that are uniquely produced in Camelidae, e.g. camels and llamas. They have the desirable features of small sizes (Mw < 14 kDa) and high affinities against antigens ... [more ▼]

Nanobodies are single chain antibodies that are uniquely produced in Camelidae, e.g. camels and llamas. They have the desirable features of small sizes (Mw < 14 kDa) and high affinities against antigens (Kd approximately nM), making them ideal as structural probes for biomedically relevant motifs both in vitro and in vivo. We have previously shown that nanobody binding to amyloidogenic human lysozyme variants can effectively inhibit their aggregation, the process that is at the origin of systemic amyloid disease. Here we report the NMR assignments of a new nanobody, termed NbSyn2, which recognises the C-terminus of the intrinsically disordered protein, human alpha-synuclein (aS), whose aberrant self-association is implicated in Parkinson's disease. [less ▲]

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See detailVariability of major fatty acid contents in Luxembourg dairy cattle
Soyeurt, Hélène ULg; Arnould, Valérie ULg; Dardenne, Pierre et al

in Book of Abstracts of the 60th Annual Meeting of the European Association for Animal Production (2009)

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See detailDetection and quantification of non-linear dynamic behaviour of space structures
Hot, A.; Cogan, S.; Foltete, E. et al

in 11th European Conference on Spacecraft Structures, Materials and Mechanical Testing, Toulouse, 2009 (2009)

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See detailIdentification of equid herpesvirus-5 in respiratory liquids: A retrospective study of 785 samples taken in 2006-2007
Fortier, Guillaume; Pronost, Stéphane; Miszczak, Fabien et al

in Veterinary Journal (2009), 182

During a case control study undertaken in 2006-2007, a screening and consensus polymerase chain reaction (PCR) was performed to evaluate the potential role of equid herpesviruses (EHV) in several ... [more ▼]

During a case control study undertaken in 2006-2007, a screening and consensus polymerase chain reaction (PCR) was performed to evaluate the potential role of equid herpesviruses (EHV) in several occurrences of respiratory disorders in 661 horses. Of 785 bronchoalveolar or tracheal lavage fluid samples submitted for analysis, 20 were positive for EHV-5 DNA by sequential analysis of the consensus PCR product. Nineteen of those samples were confirmed using a specific EHV-5 PCR. No particular changes in cytological profile could be associated with the detection of EHV-5 in contrast to suggestions in previous reports of natural or experimental respiratory viral infections in horses or ponies. This is the first description of EHV-5 isolation in equine respiratory fluids in Europe, but further investigations are needed to determine the potential pathogenic role of this gammaherpesvirus in the horse. [less ▲]

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See detailDesign procedure of a nonlinear vibration absorber using bifurcation analysis: application to a drill-string system
Viguié, Régis ULg; Kerschen, Gaëtan ULg

in Euromech 503, Nonlinear Normal Modes, Dimension Reduction and Localization in Vibrating Systems, Frascati, 2009 (2009)

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See detailBipolarity in Alexis de Tocqueville’s, Karl Marx’s, Friedrich Nietzsche’s, and Michael Oakeshott’s Political Theories
Reuchamps, Min ULg

in Cahiers de Sciences Politiques de l'ULg (2009), (15),

In Democracy in America, Alexis de Tocqueville argues that passions for both equality and liberty constitute the chief attributes of liberal democracy. In the same century, Karl Marx and Friedrich Engels ... [more ▼]

In Democracy in America, Alexis de Tocqueville argues that passions for both equality and liberty constitute the chief attributes of liberal democracy. In the same century, Karl Marx and Friedrich Engels –followed by Lenin in the 20th century– contend that history is chiefly characterized by the conflict between those who own the means of productions and those who don’t –those who produce. In Beyond Good and Evil (BGE) and in On the Genealogy of Morals (OGM), Friedrich Nietzsche describes the whole of history as a permanent bipolarity between the strong –committed to the master morality of good vs. bad– and the weak –committed to the slave morality of good vs. evil. Michael Oakeshott, in The Politics of Faith and The Politics of Scepticism, suggests that, since the fifteenth century, modern politics can be characterized by two –logically opposite and yet practically complementary– styles of politics: the politics of faith and the politics of scepticism. Although they disagree on the characterization of the poles themselves, all four philosophers describe politics as a bipolarity: a dynamic between two poles. In this paper, I shall attempt to describe –and then reflect on– the dynamics of bipolarity in these four major works of political theory. Six sets of questions inform the essay. First, was there ever a time in which the political poles identified by the author were either nonexistent or different from the currently predominant or ultimate ones? If so, then why and what were the characteristics of that time? Second, what characterizes the political poles? Are the apparent poles more complicated than what meets the eye upon a first reading? Does the author reveal dimensions, levels, or different incarnations of the poles, or in fact more than two poles? Third, are the characteristics of the poles altered in any way by either political actors, or by way of their confrontation or interaction with one another? If so, how? If not, then why not? Fourth, does the identified bipolarity spontaneously create a political equilibrium or evolve into another, or is intervention required to produce an equilibrium or evolution? Fifth, if the latter, does the author recommend such intervention? Does the author give a normative teaching or assess the identified poles? Sixth, is the bipolarity theory valid? Does it accurately describe politics? The paper opens with the discussion of the first two sets of questions –i.e. the characterization of politics by Tocqueville, Marx, Nietzsche, and Oakeshott. The second section focuses on the intricate dynamics between the poles and on the mediation occurring between them –i.e. the third and fourth sets of questions. The fifth sets of question –i.e. whether the author gives a descriptive or a normative teaching– informs the third section of the paper. In the conclusion, I attempt to offer a personal view to the final question –i.e. the validity of the bipolarity theory offered by the four philosophers– and try to answer it in the Belgian federal context. [less ▲]

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See detailCo-infection with two closely related alphaherpesviruses results in a highly diversified recombination mosaic displaying negative genetic interference
Muylkens, Benoît ULg; Farnir, Frédéric ULg; Meurens, François et al

in Journal of Virology (2009), 83(7), 3127-3137

Phylogenetic studies of the emergence and spread of natural recombinants in herpesviruses infecting humans and animals have been reported recently. However, despite an ever-increasing amount of evidence ... [more ▼]

Phylogenetic studies of the emergence and spread of natural recombinants in herpesviruses infecting humans and animals have been reported recently. However, despite an ever-increasing amount of evidence of recombination in herpesvirus history, the recombination process and the consequences on the genetic diversity of the progeny remain poorly characterized. We addressed this issue by using multiple single-nucleotide polymorphisms (SNPs) differentiating the two subtypes of an alphaherpesvirus, bovine herpesvirus 1 (BoHV-1). Analysis of a large sample of progeny virions obtained in a single growth cycle of coinfected BoHV-1 strains provided a prospective investigation of the recombination dynamics by using SNPs as recombination markers. We found that the simultaneous infection with two closely related herpesviruses results in a highly diversified recombination mosaic. From the analysis of multiple recombinants arising in the progeny, we provide the first evidence of genetic interference influencing the recombination process in herpesviruses. In addition, we report striking differences in the levels of recombination frequency observed along the BoHV-1 genome. With particular emphasis on the genetic structure of a progeny virus population rising in vitro, our data show to which extent recombination participates to the genetic diversification of herpesviruses [less ▲]

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See detailLarge scale experimental study of piano key weirs
Machiels, Olivier ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Proc. 33rd IAHR Congress: Water Engineering for a Sustainable Environment (2009)

Piano Key Weirs (PKW) are a new type of weir, showing very good flood release capacities as well as strong economic and structural benefits. However, lacks of understanding persist about the flow ... [more ▼]

Piano Key Weirs (PKW) are a new type of weir, showing very good flood release capacities as well as strong economic and structural benefits. However, lacks of understanding persist about the flow conditions on such structures. With the goal to fill some of these lacks, a combined experimental and numerical study has been undertaken at the Laboratory of Structures Hydraulics of the University of Liege. This paper presents the goals and the scientific strategy of this research. The first results of experiments being carried out on a large physical model of PKW are also depicted. These experiments lead to characterization of the flow behavior for low heads and enable to highlight the influence of the crest thickness and the outlet slope on the release capacity. [less ▲]

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See detailDéveloppement durable des races bovines locales menacées
Bay, Elodie

Article for general public (2009)

Le projet EURECA a pour but d'assister la conservation, le développement et l'utilisation des races bovines locales, et ce en se basant sur l'étude de races locales dans 10 pays européens. Ce projet (d ... [more ▼]

Le projet EURECA a pour but d'assister la conservation, le développement et l'utilisation des races bovines locales, et ce en se basant sur l'étude de races locales dans 10 pays européens. Ce projet (d'une durée totale de 3 ans) est coordonné au niveau belge par le Faculté des Sciences Agronomiques de Gembloux. La première phase du projet, présentée dans cet article, a consisté à interroger des éleveurs et des parties prenantes à l'aide d'un formulaire standard, afin de comprendre comment s'intègre les races locales au niveau des différents intervenants. L'étude a porté sur la Pie Rouge Mixte (PRm) et la Blanc Bleu Mixte (BBm). [less ▲]

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See detailGuideline for resuscitation in cardiac arrest after cardiac surgery.
Dunning, Joel; Fabbri, Alessandro; Kolh, Philippe ULg et al

in European Journal of Cardio - Thoracic Surgery (2009), 36(1), 3-28

The Clinical Guidelines Committee of the European Association for Cardio-Thoracic Surgery provides this professional view on resuscitation in cardiac arrest after cardiac surgery. This document was ... [more ▼]

The Clinical Guidelines Committee of the European Association for Cardio-Thoracic Surgery provides this professional view on resuscitation in cardiac arrest after cardiac surgery. This document was created using a multimodal methodology for evidence generation including the extrapolation of existing guidelines from the International Liaison Committee on Resuscitation where possible, our own structured literature reviews on issues particular to cardiac surgery, an international survey on resuscitation hosted by CTSNet and manikin simulations of potential protocols. This protocol differs from existing generic guidelines in a number of areas, the most import of which are the following: successful treatment of cardiac arrest after cardiac surgery is a multi-practitioner activity with six key roles that should be allocated and rehearsed on a regular basis; in ventricular fibrillation, three sequential attempts at defibrillation (where immediately available) should precede external cardiac massage; in asystole or extreme bradycardia, pacing (where immediately available) should precede external cardiac massage; where the above measures fail, and in pulseless electrical activity, early resternotomy is advocated; adrenaline should not be routinely given; protocols for excluding reversible airway and breathing complications and for safe emergency resternotomy are given. This guideline is subject to continuous informal review, and when new evidence becomes available. [less ▲]

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See detailEx vivo expansion of hematopoietic progenitor cells is associated with downregulation of alpha4 integrin- and CXCR4-mediated engraftment in NOD/SCID beta2-microglobulin-null mice
Foguenne, Jacques ULg; Di Stefano; Giet, Olivier ULg et al

in Haematologica (2009), 94

Several studies indicate that ex vivo cytokine-supported expansion induces defective hematopoietic stem cell engraftment. We investigated the role of alpha4 integrin, alpha5 integrin and CXCR4 in ... [more ▼]

Several studies indicate that ex vivo cytokine-supported expansion induces defective hematopoietic stem cell engraftment. We investigated the role of alpha4 integrin, alpha5 integrin and CXCR4 in engraftment of unmanipulated and cytokine-treated human cord blood CD34+ cells. [less ▲]

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See detailFeline herpesvirus infection. ABCD guidelines on prevention and management
Thiry, Etienne ULg; Addie, D.; Belak, B. et al

in Journal of Feline Medicine and Surgery (2009), 11

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See detailProduction des anticorps monoclonaux
Mistretta, Virginie ULg; Cavalier, Etienne ULg; Collette, Julien ULg et al

in Revue Médicale de Liège (2009), 64(5-6), 248-252

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See detailAdhesion and growth inhibitory effect of chicken egg yolk antibody (IgY) on Salmonella enterica serovars Enteritidis and Typhimurium in vitro.
Chalghoumi, Raja; Thewis, André ULg; Beckers, Yves ULg et al

in Foodborne Pathogens and Disease (2009), 6(5), 593-604

The protective effects of powder preparation of egg yolk immunoglobulin Y (IgY), specific to Salmonella Enteritidis and Salmonella Typhimurium outer membrane proteins (OMP), against these two Salmonella ... [more ▼]

The protective effects of powder preparation of egg yolk immunoglobulin Y (IgY), specific to Salmonella Enteritidis and Salmonella Typhimurium outer membrane proteins (OMP), against these two Salmonella sp. serovars were investigated in vitro in two different assays: adhesion-prevention and growth-inhibition. The adhesion-prevention assay was conducted using polarized monolayers of the human intestinal epithelial Caco-2 cell line. First, the conditions of Salmonella adherence to Caco-2 cells were optimized, and interferences of bacteria with the transepithelial electrical resistance (TER) of fully differentiated Caco-2 cell monolayers and the lactate dehydrogenase release upon exposure of the cells to Salmonella were evaluated. Both Salmonella sp. serovars were able to adhere to Caco-2 cells and decreased TER. Results from the adhesion-prevention assay demonstrated that specific IgY reduced the decrease in TER of the infected Caco-2 cell monolayers and blocked the Salmonella sp. adhesion in a concentration-dependent manner (p < 0.05). Nonspecific IgY also exhibited an inhibitory effect on these two parameters, but to a lesser extent than that of the specific IgY (p < 0.05). The protective effect of nonspecific IgY could be attributed to the low-density lipoprotein component of the water-soluble fraction of egg yolks that may not have been eliminated during ultrafiltration. The growth-inhibition assay revealed that specific IgY had an inhibitory effect on the bacterial growth, markedly during the late exponential phase, whereas nonspecific IgY failed to do so. Taken together, these results suggest that the in vitro growth inhibitory effect of specific IgY on Salmonella spp. resulted from the specific binding activity of these IgY to Salmonella sp. OMP. Passive immunization with Salmonella sp. OMP-specific IgY could thus be useful to prevent Salmonella colonization in broiler chickens and the subsequent carcass contamination during processing. [less ▲]

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See detailDecentralized reactive power dispatch for a time-varying multi-TSO system
Phulpin, Yannick; Begovic, Miroslav; Petit, Marc et al

in Proceedings of the 42nd Hawaii International Conference on System Sciences (HICSS-42) (2009)

This paper addresses the problem of reactive power dispatch in a power system partitioned into several areas controlled by different transmission system operators. Previous research has shown that nearly ... [more ▼]

This paper addresses the problem of reactive power dispatch in a power system partitioned into several areas controlled by different transmission system operators. Previous research has shown that nearly optimal performance could be achieved in a time-invariant system by using a specific iterative decentralized control scheme with no information exchange. At each iteration of this scheme, every transmission system operator concurrently schedules its own control settings for the next iteration while representing the neighboring areas with external network equivalents. This paper focuses on some parameter tracking techniques to extend the range of application of the decentralized control scheme to time-varying systems, where the time-varying nature of the system is modeled as a succession of steady-state operating conditions with variation of the load demand. Those new techniques are evaluated in the context of IEEE 118 bus system partitioned into three control areas. [less ▲]

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See detailExplaining thermal failure in saturated clays
Hueckel, Tomasz; François, Bertrand ULg; Lyesse, Laloui

in Geotechnique (2009), 59(3), 197-212

Failure conditions in soils at elevated temperatures appear to be strongly dependent on the history of the application of stress and temperature. Four cases of such history leading to various modes of ... [more ▼]

Failure conditions in soils at elevated temperatures appear to be strongly dependent on the history of the application of stress and temperature. Four cases of such history leading to various modes of failure are identified and interpreted in terms of thermal Cam-clay models. Particular attention is given to the influence of thermal variability on the coefficient of the critical state, M, or the angle of internal friction. A detailed analysis of the material history offers an explanation of an apparent confusion about whether the soil strength is decreased or increased by temperature. In a companion paper, numerical analysis of the development of axisymmetric thermal and stress fields around a cylindrical heat source suggests that thermal failure may arise in conditions that are far from any mechanically critical situation. [less ▲]

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See detailOperational Determination of Multiqubit Entanglement Classes
Bastin, Thierry ULg

Conference (2009)

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