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See detailFaciogenital dysplasia protein Fgd1 regulates invadopodia biogenesis and extracellular matrix degradation and is up-regulated in prostate and breast cancer.
Ayala, Inmaculada; Giacchetti, Giada; Caldieri, Giusi et al

in Cancer Research (2009), 69(3), 747-52

Invadopodia are proteolytically active membrane protrusions that extend from the ventral surface of invasive tumoral cells grown on an extracellular matrix (ECM). The core machinery controlling ... [more ▼]

Invadopodia are proteolytically active membrane protrusions that extend from the ventral surface of invasive tumoral cells grown on an extracellular matrix (ECM). The core machinery controlling invadopodia biogenesis is regulated by the Rho GTPase Cdc42. To understand the upstream events regulating invadopodia biogenesis, we investigated the role of Fgd1, a Cdc42-specific guanine nucleotide exchange factor. Loss of Fgd1 causes the rare inherited human developmental disease faciogenital dysplasia. Here, we show that Fgd1 is required for invadopodia biogenesis and ECM degradation in an invasive cell model and functions by modulation of Cdc42 activation. We also find that Fgd1 is expressed in human prostate and breast cancer as opposed to normal tissue and that expression levels matched tumor aggressiveness. Our findings suggest a central role for Fgd1 in the focal degradation of the ECM in vitro and, for the first time, show a connection between Fgd1 and cancer progression, proposing that it might function during tumorigenesis. [less ▲]

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See detailTechnologies de l'Information et de la Communication pour l'Éducation et la Formation en contexte scolaire (TIC-EF)
Denis, Brigitte ULg

Learning material (2009)

Le cours comprend les chapitres suivants : 1. Approche systémique de la formation initiale et continue des enseignants aux usages des TICE 2. Analyse d’activités de formation/apprentissage recourant aux ... [more ▼]

Le cours comprend les chapitres suivants : 1. Approche systémique de la formation initiale et continue des enseignants aux usages des TICE 2. Analyse d’activités de formation/apprentissage recourant aux TIC et discussion de leurs apports à l’enseignement 3. Analyse de dispositifs de formation recourant aux TIC sous l’angle de l’innovation 4. Évaluation de la qualité ergonomique et pédagogique de produits multimédias et de sites Web éducatifs 5. Création de scénarios pédagogiques intégrant les TIC 6. Problématiques d’évaluation et leur instrumentation à l’aide des TIC [less ▲]

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See detailCriminologie en criminaliteitsbeleid: tussen mensenrechten en doeltreffende criminaliteitsbeheersing
Lauwaert, Katrien ULg; Wolthuis, Annemieke

in Tijdschrift voor Herstelrecht (2009), 9(3), 65-72

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See detailModeling medium-scale TEC structures observed by Belgian GPS receivers network
Kutiev, Ivan; Marinov, Pencho; Fidanova, Stefka et al

in Advances in Space Research (2009), 43

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See detailSome facts about sleep relevant for Landau-Kleffner syndrome.
Mascetti, Laura ULg; Foret, Ariane ULg; Bonjean, Maxime et al

in Epilepsia (2009), 50 Suppl 7

Our understanding of the neural mechanisms of non-rapid eye movement sleep (NREM) is steadily increasing. Given the intriguing activation of paroxysmal activity during NREM sleep in patients with Landau ... [more ▼]

Our understanding of the neural mechanisms of non-rapid eye movement sleep (NREM) is steadily increasing. Given the intriguing activation of paroxysmal activity during NREM sleep in patients with Landau-Kleffner syndrome (LKS), a thorough characterization of commonalities and differences between the neural correlates of LKS paroxysms and normal sleep oscillations might provide useful information on the neural underpinning of this disorder. Especially, given the suspected role of sleep in brain plasticity, this type of information is needed to assess the link between cognitive deterioration and electroencephalography (EEG) paroxysms during sleep. [less ▲]

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See detailDecentralized reactive power dispatch for a time-varying multi-TSO system
Phulpin, Yannick; Begovic, Miroslav; Petit, Marc et al

in Proceedings of the 42nd Hawaii International Conference on System Sciences (HICSS-42) (2009)

This paper addresses the problem of reactive power dispatch in a power system partitioned into several areas controlled by different transmission system operators. Previous research has shown that nearly ... [more ▼]

This paper addresses the problem of reactive power dispatch in a power system partitioned into several areas controlled by different transmission system operators. Previous research has shown that nearly optimal performance could be achieved in a time-invariant system by using a specific iterative decentralized control scheme with no information exchange. At each iteration of this scheme, every transmission system operator concurrently schedules its own control settings for the next iteration while representing the neighboring areas with external network equivalents. This paper focuses on some parameter tracking techniques to extend the range of application of the decentralized control scheme to time-varying systems, where the time-varying nature of the system is modeled as a succession of steady-state operating conditions with variation of the load demand. Those new techniques are evaluated in the context of IEEE 118 bus system partitioned into three control areas. [less ▲]

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See detailDesign procedure of a nonlinear vibration absorber using bifurcation analysis : application to the drill-string system
Viguié, Régis ULg; Kerschen, Gaëtan ULg

in ASME International Design Engineering Technical Conferences, San Diego, 2009 (2009)

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See detailVariability of major fatty acid contents in Luxembourg dairy cattle
Soyeurt, Hélène ULg; Arnould, Valérie ULg; Dardenne, Pierre et al

in Book of Abstracts of the 60th Annual Meeting of the European Association for Animal Production (2009)

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See detailAnalyse des coûts/bénéfices dans le cadre de la lutte contre Diahotica virgifera Le Conte
Louppe, H.; Burny, Philippe ULg; De Proft, M. et al

Report (2009)

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See detailLarge scale experimental study of piano key weirs
Machiels, Olivier ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Proc. 33rd IAHR Congress: Water Engineering for a Sustainable Environment (2009)

Piano Key Weirs (PKW) are a new type of weir, showing very good flood release capacities as well as strong economic and structural benefits. However, lacks of understanding persist about the flow ... [more ▼]

Piano Key Weirs (PKW) are a new type of weir, showing very good flood release capacities as well as strong economic and structural benefits. However, lacks of understanding persist about the flow conditions on such structures. With the goal to fill some of these lacks, a combined experimental and numerical study has been undertaken at the Laboratory of Structures Hydraulics of the University of Liege. This paper presents the goals and the scientific strategy of this research. The first results of experiments being carried out on a large physical model of PKW are also depicted. These experiments lead to characterization of the flow behavior for low heads and enable to highlight the influence of the crest thickness and the outlet slope on the release capacity. [less ▲]

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See detailBiology of bovine herpesvirus 5
Del Medico Zajac, M. P.; Ladelfa, M. F.; Kotsias, F. et al

in Veterinary Journal (2009)

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See detailFirst-Principles conductance of nanoscale junctions from the polarizability of finite systems
Verstraete, Matthieu ULg; Bokes, Peter; Godby, Rex W

in Journal of Chemical Physics (2009), 130

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See detailDéveloppement durable des races bovines locales menacées
Bay, Elodie

Article for general public (2009)

Le projet EURECA a pour but d'assister la conservation, le développement et l'utilisation des races bovines locales, et ce en se basant sur l'étude de races locales dans 10 pays européens. Ce projet (d ... [more ▼]

Le projet EURECA a pour but d'assister la conservation, le développement et l'utilisation des races bovines locales, et ce en se basant sur l'étude de races locales dans 10 pays européens. Ce projet (d'une durée totale de 3 ans) est coordonné au niveau belge par le Faculté des Sciences Agronomiques de Gembloux. La première phase du projet, présentée dans cet article, a consisté à interroger des éleveurs et des parties prenantes à l'aide d'un formulaire standard, afin de comprendre comment s'intègre les races locales au niveau des différents intervenants. L'étude a porté sur la Pie Rouge Mixte (PRm) et la Blanc Bleu Mixte (BBm). [less ▲]

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See detailWho's in charge? Nuclear receptor coactivator and corepressor function in brain and behavior.
Tetel, M. J.; Auger, A. P.; Charlier, Thierry ULg

in Frontiers in Neuroendocrinology (2009), 30

Steroid hormones act in brain and throughout the body to regulate a variety of functions, including development, reproduction, stress and behavior. Many of these effects of steroid hormones are mediated ... [more ▼]

Steroid hormones act in brain and throughout the body to regulate a variety of functions, including development, reproduction, stress and behavior. Many of these effects of steroid hormones are mediated by their respective receptors, which are members of the steroid/nuclear receptor superfamily of transcriptional activators. A variety of studies in cell lines reveal that nuclear receptor coregulators are critical in modulating steroid receptor-dependent transcription. Thus, in addition to the availability of the hormone and the expression of its receptor, nuclear receptor coregulators are essential for efficient steroid-dependent transactivation of genes. This review will highlight the importance of nuclear receptor coregulators in modulating steroid-dependent gene expression in brain and the regulation of behavior. [less ▲]

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See detailLes marchés publics par l'analyse de cas : n°1 à 10
Durviaux, Ann-Lawrence ULg; Simar, Renaud ULg

Learning material (2009)

support écrit des travaux pratiques sous forme de casus et de propositions de résolution

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See detailEmission line stars in the Milky Way with the GAIA space mission
Martayan, C.; Frémat, Y.; Blomme, R. et al

Poster (2009)

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See detailGuideline for resuscitation in cardiac arrest after cardiac surgery.
Dunning, Joel; Fabbri, Alessandro; Kolh, Philippe ULg et al

in European Journal of Cardio - Thoracic Surgery (2009), 36(1), 3-28

The Clinical Guidelines Committee of the European Association for Cardio-Thoracic Surgery provides this professional view on resuscitation in cardiac arrest after cardiac surgery. This document was ... [more ▼]

The Clinical Guidelines Committee of the European Association for Cardio-Thoracic Surgery provides this professional view on resuscitation in cardiac arrest after cardiac surgery. This document was created using a multimodal methodology for evidence generation including the extrapolation of existing guidelines from the International Liaison Committee on Resuscitation where possible, our own structured literature reviews on issues particular to cardiac surgery, an international survey on resuscitation hosted by CTSNet and manikin simulations of potential protocols. This protocol differs from existing generic guidelines in a number of areas, the most import of which are the following: successful treatment of cardiac arrest after cardiac surgery is a multi-practitioner activity with six key roles that should be allocated and rehearsed on a regular basis; in ventricular fibrillation, three sequential attempts at defibrillation (where immediately available) should precede external cardiac massage; in asystole or extreme bradycardia, pacing (where immediately available) should precede external cardiac massage; where the above measures fail, and in pulseless electrical activity, early resternotomy is advocated; adrenaline should not be routinely given; protocols for excluding reversible airway and breathing complications and for safe emergency resternotomy are given. This guideline is subject to continuous informal review, and when new evidence becomes available. [less ▲]

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See detailEx vivo expansion of hematopoietic progenitor cells is associated with downregulation of alpha4 integrin- and CXCR4-mediated engraftment in NOD/SCID beta2-microglobulin-null mice
Foguenne, Jacques ULg; Di Stefano; Giet, Olivier ULg et al

in Haematologica (2009), 94

Several studies indicate that ex vivo cytokine-supported expansion induces defective hematopoietic stem cell engraftment. We investigated the role of alpha4 integrin, alpha5 integrin and CXCR4 in ... [more ▼]

Several studies indicate that ex vivo cytokine-supported expansion induces defective hematopoietic stem cell engraftment. We investigated the role of alpha4 integrin, alpha5 integrin and CXCR4 in engraftment of unmanipulated and cytokine-treated human cord blood CD34+ cells. [less ▲]

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See detailThe fluid trampoline: droplets bouncing on a soap film
Gilet, Tristan ULg; Bush, John W.M.

in Journal of Fluid Mechanics (2009), 625

We present the results of a combined experimental and theoretical investigation of droplets falling onto a horizontal soap film. Both static and vertically vibrated soap films are considered. In the ... [more ▼]

We present the results of a combined experimental and theoretical investigation of droplets falling onto a horizontal soap film. Both static and vertically vibrated soap films are considered. In the static case, a variety of behaviours were observed, including bouncing, crossing and partial coalescence. A quasi-static description of the soap film shape yields a force–displacement relation that provides excellent agreement with experiment, and allows us to model the film as a nonlinear spring. This approach yields an accurate criterion for the transition between droplet bouncing and crossing. Moreover, it allows us to rationalize the observed constancy of the contact time and scaling for the coefficient of restitution in the bouncing states. On the vibrating film, a variety of bouncing behaviours were observed, including simple and complex periodic states, multi-periodicity and chaos. A simple theoretical model is developed that captures the essential physics of the bouncing process, reproducing all observed bouncing states. The model enables us to rationalize the observed coexistence of multiple periodic bouncing states by considering the dependence of the energy transferred to the droplet on the phase of impact. Quantitative agreement between model and experiment is deduced for simple periodic modes, and qualitative agreement for more complex periodic and chaotic bouncing states. Analytical solutions are deduced in the limit of weak forcing and dissipation, yielding insight into the contact time and periodicity of the bouncing states. [less ▲]

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See detailGeneration of total angular momentum eigenstates in remote qubits
Maser, A.; Schilling, U.; Bastin, Thierry ULg et al

Conference (2009)

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