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See detailEvaluation of the contamination of North Sea Porpoises (Phocoena phocoena) by endocrine disrupting chemicals using CG-MS and in vitro assays
Didimo Imazaki, Pedro Henrique ULg; Brose, François ULg; Remacle, Anne-Sophie ULg et al

Poster (2009)

During the last decades, the production of endocrine disrupting chemicals reached such elevated levels that they are now spread all over the environment. Endocrine disrupting chemicals are known to be ... [more ▼]

During the last decades, the production of endocrine disrupting chemicals reached such elevated levels that they are now spread all over the environment. Endocrine disrupting chemicals are known to be very slowly degraded, decreasing the environmental quality and causing ecological risks. Marine mammals inhabiting polluted environments accumulate high quantities of these chemicals, and are good indicators of marine pollution Thirteen major organochloride pollutants (known from literature to contaminate north sea porpoise) were chosen in this study – o,p’-DDD; p,p’-DDD; p,p’-DDE; o,p’-DDT; p,p’-DDT; HCB; α-HCH; β-HCH; γ-HCH; δ-HCH; PCB 138; PCB 153 and PCB 180. The thirteen chemicals were tested individually and in mixtures by the use of report gene expression assays. The MCF7-ERE cells used in the assays were originated from MCF7 human mammary tumor cells transfected with the ERE-luciferase reporter system. Preliminary results suggest that o,p’-DDD; p,p’-DDD; o,p’-DDT; HCB; β-HCH; δ-HCH; PCB 138 and PCB 180 are able to stimulate the luciferase expression of MCF7-ERE cells when they are present individually or in mixtures. No synergism was observed within mixtures. When MCF7-ERE cells were exposed to the chemicals and 17β-oestradiol simultaneously, p,p’-DDE; α-HCH; PCB 138 and PCB 180 could raise the luciferase expression in comparison to the exposition of 17β-oestradiol alone; on the other hand, o,p’-DDD; p,p’-DDT; HCB; β-HCH; γ-HCH and δ-HCH seem to inhibit the luciferase expression at low doses. In the next step, the pollutants will be searched and quantified in the blubber tissue of porpoises by use of gas chromatography-mass spectrometry. The blubber tissue samples will also have their endocrine disrupting effects characterized. This work is ongoing and It is expected a relevant level of these compounds to be found in the samples. Conversely, their endocrine disrupting effects and how they act in agonist, antagonist ways are subject that still needs to be studied. [less ▲]

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See detailImpact of bone marker feedback on adherence to once monthly ibandronate for osteoporosis among Asian postmenopausal women
Kung, Annie Wai-Chee; Rachman, A Ichramsjah; Adam, MF John et al

in International Journal of Rheumatic Diseases (2009), 12

Aim: This study assesses the impact of serum carboxy-terminal collagen crosslinks (CTX) bone marker feedback (BMF) on adherence to ibandronate treatment in Asian postmenopausal women with osteoporosis ... [more ▼]

Aim: This study assesses the impact of serum carboxy-terminal collagen crosslinks (CTX) bone marker feedback (BMF) on adherence to ibandronate treatment in Asian postmenopausal women with osteoporosis. Methods: This was a 12-month (6-monthly phased), randomized, prospective, open-label, multi-center study conducted in 596 (of 628 enrolled) postmenopausal women with osteoporosis (£ 85 years old) who were naı¨ve, lapsed, or current bisphosphonate users. Patients were randomized into two arms: serum CTX BMF at 3 months versus no-BMF. Once-monthly 150 mg ibandronate tablet was administered for 12 months and adherence to therapy was assessed at 6 and 12 months. In addition, patient satisfaction and safety of ibandronate treatment were also assessed. Results: Serum CTX BMF at 3 months showed no impact on adherence. The proportions of adherent patients were comparable in the BMF versus no-BMF arms (92.6% vs. 96.0%, P = 0.16); overall, serum CTX levels were similar for adherent and non-adherent patients. However, BMF patients felt more informed about their osteoporosis (P < 0.001) and more satisfied (P < 0.01) than no-BMF patients. Conclusions: The Asian postmenopausal osteoporosis patients in this study had a high adherence rate to once-monthly ibandronate therapy. Use of serum CTX BMF had no further impact on increasing adherence, but increased treatment satisfaction. [less ▲]

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See detailHistopathological diagnosis of a type vii mucopolysaccharidosis after pregnancy termination.
Delbecque, Katty ULg; Gaillez, Stephanie ULg; Schaaps, Jean-Pierre ULg

in Fetal & Pediatric Pathology (2009), 28(1), 1-8

Type VII mucopolysaccharidosis is a very rare recessive lysosomal storage disease. We diagnosed a type VII MPS in a case of severe fetal hydrops after pregnancy termination at 23 weeks of gestation. The ... [more ▼]

Type VII mucopolysaccharidosis is a very rare recessive lysosomal storage disease. We diagnosed a type VII MPS in a case of severe fetal hydrops after pregnancy termination at 23 weeks of gestation. The diagnosis was suspected on histopathological examination by the presence of foam cells in many viscera and foamy placental Hofbauer cells. Enzyme assay on cultured amniotic cells showed a markedly deficient beta-glucuronidase activity, thus confirming the diagnosis. This report shows the importance of a precise necropsy diagnosis in nonimmune hydrops because of putative implications for genetic counseling and prenatal diagnosis in subsequent pregnancies. [less ▲]

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See detailLa fin de la récréation pour l'opérateur historique? Annotation de la décision du Conseil de la concurrence dans l'affaire Belgacom/Scarlet, 7 novembre 2008
Petit, Nicolas ULg; Daems, Ief

in revue de la concurrence belge (2009), (3),

Le Conseil belge de la concurrence a décidé de subordonner l'autorisation de la concentration entre Belgacom et Scarlet à la mise en oeuvre de diverses mesures correctives structurelles et ... [more ▼]

Le Conseil belge de la concurrence a décidé de subordonner l'autorisation de la concentration entre Belgacom et Scarlet à la mise en oeuvre de diverses mesures correctives structurelles et comportementales. [less ▲]

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See detailUnemployment and retirement in a model with age-specific heterogeneity
Lefebvre, Mathieu ULg

E-print/Working paper (2009)

This paper presents a model where young and old workers compete for one type of jobs in the presence of retirement opportunity. Within this framework, we show that increased retirement opportunities (such ... [more ▼]

This paper presents a model where young and old workers compete for one type of jobs in the presence of retirement opportunity. Within this framework, we show that increased retirement opportunities (such as early retirement) has most of the time a depressing impact on the unemployment rate. Indeed the number of vacancies posted by firms is influenced by the probability that an old worker is going into retirement. We show that the degree to which younger workers are influenced by retirement of older workers depends on the relative productivity of young and older workers. It is only when older workers are much more productive than young workers that retirement may benefi t to unemployment. [less ▲]

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See detailUne nouvelle macle de la pyrrhotite sur un échantillon de la mine El ,Potosi, Santa Eulalia, Chihuahua, Mexique
Philippo, Simon; Hatert, Frédéric ULg

in Le règne minéral (2009), 90

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See detailCompression induces the expression of a sclerotic phenotype in human subchondral osteoblasts
Sanchez, Christelle ULg; Gabay, Odile; Pesesse, Laurence ULg et al

in Osteoarthritis and Cartilage (2009), 17(suppl 1), 95

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See detailA discontinuous Galerkin formulation of non-linear Kirchhoff–Love shells
Noels, Ludovic ULg

in International Journal for Numerical Methods in Engineering (2009), 78(3), 296-323

Discontinuous Galerkin (DG) methods provide a means of weakly enforcing the continuity of the unknown-field derivatives and have particular appeal in problems involving high-order derivatives. This ... [more ▼]

Discontinuous Galerkin (DG) methods provide a means of weakly enforcing the continuity of the unknown-field derivatives and have particular appeal in problems involving high-order derivatives. This feature has previously been successfully exploited (Comput. Methods Appl. Mech. Eng. 2008; 197:2901-2929) to develop a formulation of linear Kirchhoff-Love shells considering only the membrane and bending responses. In this proposed one-field method - the displacements are the only unknowns, while the displacement field is continuous, the continuity in the displacement derivative between two elements is weakly enforced by recourse to a DG formulation. It is the purpose of the present paper to extend this formulation to finite deformations and non-linear elastic behaviors. While the initial linear formulation was relying on the direct linear computation of the effective membrane stress and effective bending couple-stress from the displacement field at the mid-surface of the shell, the non-linear formulation considered implies the evaluation of the general stress tensor across the shell thickness, leading to a reformulation of the internal forces of the shell. Nevertheless, since the interface terms resulting from the discontinuous Galerkin method involve only the resultant couple-stress at the edges of the shells, the extension to non-linear deformations is straightforward. [less ▲]

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See detailSubchondral bone in osteoarthritis physiopathology: state-of-the art and perspectives.
Henrotin, Yves ULg; Pesesse, Laurence ULg; Sanchez, Christelle ULg

in Bio-medical Materials & Engineering (2009), 19(4-5), 311-6

Osteoarthritis (OA) is the most common form of arthritic disease, and it is a major cause of disability and impaired quality of life in the elderly. A hallmark of the disease is progressive degeneration ... [more ▼]

Osteoarthritis (OA) is the most common form of arthritic disease, and it is a major cause of disability and impaired quality of life in the elderly. A hallmark of the disease is progressive degeneration of articular cartilage and subsequent joint space narrowing. However, OA is a complex disease not limited to cartilage degeneration, but involving also synovial membrane and subchondral bone, thereby presenting alternatives approaches for treatment. In this paper, we propose a short review of the recent advances in the understanding of the role played by subchondral bone in OA. [less ▲]

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See detailLocalization of Nopp140 within mammalian cells during interphase and mitosis.
Thiry, Marc ULg; Cheutin, Thierry; Lamaye, Françoise ULg et al

in Histochemistry & Cell Biology (2009), 132(2), 129-40

We investigated distribution of the nucleolar phosphoprotein Nopp140 within mammalian cells, using immunofluorescence confocal microscopy and immunoelectron microscopy. During interphase, three ... [more ▼]

We investigated distribution of the nucleolar phosphoprotein Nopp140 within mammalian cells, using immunofluorescence confocal microscopy and immunoelectron microscopy. During interphase, three-dimensional image reconstructions of confocal sections revealed that nucleolar labelling appeared as several tiny spheres organized in necklaces. Moreover, after an immunogold labelling procedure, gold particles were detected not only over the dense fibrillar component but also over the fibrillar centres of nucleoli in untreated and actinomycin D-treated cells. Labelling was also consistently present in Cajal bodies. After pulse-chase experiments with BrUTP, colocalization was more prominent after a 10- to 15-min chase than after a 5-min chase. During mitosis, confocal analysis indicated that Nopp140 organization was lost. The protein dispersed between and around the chromosomes in prophase. From prometaphase to telophase, it was also detected in numerous cytoplasmic nucleolus-derived foci. During telophase, it reappeared in the reforming nucleoli of daughter nuclei. This strongly suggests that Nopp140 could be a component implicated in the early steps of pre-rRNA processing. [less ▲]

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See detailIntegrated structure and control design for mechatronic systems with configuration-dependent dynamics
Da Silva, Maíra Martins; Bruls, Olivier ULg; Desmet, Wim et al

in Mechatronics (2009), 44(9), 10161025

This paper considers the optimal design of mechatronic systems with configuration-dependent dynamics. An optimal mechatronic design requires that, among the structural and control parameters, an optimal ... [more ▼]

This paper considers the optimal design of mechatronic systems with configuration-dependent dynamics. An optimal mechatronic design requires that, among the structural and control parameters, an optimal choice has to be made with respect to design specifications in the different domains. Two main challenges are treated in this paper: the non-convex nature of the optimization problem and the difficulty in modeling serial machines with flexible components and their embedded controllers. The optimization problem is treated using the direct design strategy which considers simultaneously structural and control parameters as variables and adopts non-convex optimization algorithms. Linear time-invariant and gain-scheduling PID controllers are addressed. This methodology is exploited for the multi-objective optimization of a pick-and-place assembly robot with a gripper carried by a variable-length flexible beam. The resulting design tradeoffs between system accuracy and control efforts demonstrate the advantage of an integrated design approach for mechatronic systems with configuration-dependent dynamics. 2009 Elsevier Ltd. All rights reserved. [less ▲]

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See detailDoes implicit memory during anaesthesia persist in children?
Lopez, Ursula; Habre, w; Laurencon, M. et al

in British Journal of Anaesthesia (2009), 102(3), 37984

Background. Recent studies suggest that implicit memory (especially perceptual implicit memory) persists during adequate general anaesthesia in adults. Studies in children, however, have failed to ... [more ▼]

Background. Recent studies suggest that implicit memory (especially perceptual implicit memory) persists during adequate general anaesthesia in adults. Studies in children, however, have failed to demonstrate implicit memory during general anaesthesia, possibly because of differences in methodological design. We therefore designed a prospective study with the aim of evaluating implicit memory in children undergoing general anaesthesia, using a perceptual memory test based on the mere exposure effect, previously tested in a control group. Methods. Twelve infrequent neutral words were played 12 times in a random sequence via headphones to 36 children aged 8–12 yr during elective or emergency surgery. The children were not premedicated, and general anaesthesia was maintained with isoflurane. The word presentation started immediately after the surgical incision. Within 36 h after the stimulus presentation, the memory was assessed by using a forced-choice preference judgement task. Time constraint and word deterioration with a low-pass filter were used to prevent the subjects from utilizing intentional retrieval. The implicit memory score was obtained by calculating the proportion of target words preferred, which was compared with the chance level (0.5). Results. The percentage of correct responses given by the children was comparable with the chance level. The memory score was mean (SD) 0.48 (0.16) (95% CI 0.43–0.53). Conclusions. The use of a perceptual implicit memory test based on the mere exposure procedure in children failed to reveal any evidence of implicit memory under general anaesthesia. [less ▲]

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See detailSozialkapital und der Neue Geist des Kapitalismus - Die Ideologie des vernetzten Menschen und neue Wege der Ausbeutung
Frère, Bruno ULg

in Neue Soziale Forschungsjournal Bewegungen (2009), 22/3

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See detailA qui l'assureur doit-il payer l'indemnité d'assurance à la suite du vol d'un véhicule en leasing?
Paris, Catherine ULg

in Revue Générale des Assurances et des Responsabilités (2009)

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See detailEvaluations of cognitive, linguistic and mnemonic competencies of people with Down’s syndrome; An integrative conception of mental retardation
Frenkel, Stéphanie ULg

in Journal of Cognitive Education and Psychology (2009), 8(2), 214-215

Thesis summary

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See detailUltrasonic internal defect detection in cheese
Leemans, Vincent ULg; Destain, Marie-France ULg

in Journal of Food Engineering (2009), 90(3), 333-340

Different ultrasonic signals and detection techniques were used and compared to detect internal foreign bodies present in semi-soft cheeses. The signals were a pulse or a chirp and the detection was ... [more ▼]

Different ultrasonic signals and detection techniques were used and compared to detect internal foreign bodies present in semi-soft cheeses. The signals were a pulse or a chirp and the detection was carried out by using either correlation with a reference signal or a wavelet decomposition. The principle of the detection consisted in measuring the time of flight of the transmitted signals and of the echoes, the latter in the absence of foreign body should be the double of the former. The presence of a foreign object affected this pattern in several ways. In order to assess the method, a small plastic cylindrical object of 3 mm in diameter was introduced in one half of the cheese and was tested for detection, the second half being used as reference for the control cheese. The results showed that the two signals and the two detection methods were able to localise the transmitted signals and the echo from the opposite face of the cheese under all circumstances. For the foreign body detection, the correlation method gave superior results, in term of signal to noise ratio as well as in term of error rate, while the two signals gave similar results. The analysis of the mean and standard deviation of the signal to noise ratio of the object echo showed that some samples presented peak values close to those due to the noise. Nevertheless, the object was detected in 90% of the tests. There was no significant effect of temperature on the detection technique. (C) 2008 Elsevier Ltd. All rights reserved. [less ▲]

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See detailShort-term post-dispersal fate of seeds defecated by two small primate species (Saguinus mystax and Saguinus fuscicollis) in the Amazonian forest of Peru
Culot, Laurence ULg; Huynen, Marie-Claude ULg; Gérard, Paul ULg et al

in Journal of Tropical Ecology (2009), 25

Post-dispersal fate of seeds dispersed by large primates is well studied but little is known about this process in small frugivores like tamarins. This study in the Amazonian forest of Peru aimed at ... [more ▼]

Post-dispersal fate of seeds dispersed by large primates is well studied but little is known about this process in small frugivores like tamarins. This study in the Amazonian forest of Peru aimed at investigating if characteristics related to the defecation patterns of tamarins (Saguinus mystax and Saguinus fuscicollis) affected short-term post-dispersal seed fate, through secondary seed dispersal by dung beetles and removal by seed predators. Data on dung beetle activity were based on direct observations of 49 defecations while seed fate was studied using semi-controlled experiments (N = 458 for secondary dispersal and N = 398 for predation). Tamarins produce small defecations with a low number of seeds. Thirty-five per cent of defecations were visited by an average of 1.5 dung beetles that usually transport the faeces as pellets. Twenty-four per cent of seeds were buried by beetles at a mean depth of 3.5 cm. With increasing quantities of faecal matter, the probability of secondary seed dispersal increased but not the depth of burial. Seed predation pressure was low (17.6%) after 4 d and higher in faeces of S. mystax than in faeces of S. fuscicollis. Despite their small size, tamarins could be considered as high-quality seed dispersers, with a potential role for forest regeneration. [less ▲]

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See detailCancers cutanés photo induits en 3D, version spécialiste
PIERARD, Gérald ULg; Andre, J.; Brochez, L. et al

Book (2009)

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