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See detailStatistical inverse analysis based on genetic algorithm and principal component analysis: Method and developments using synthetic data
Levasseur, Séverine ULg; Malécot, Yann; Boulon, Marc et al

in International Journal for Numerical and Analytical Methods in Geomechanics (2009), 33(12), 1485-1511

This study concerns the identification of parameters of soil constitutive models from geotechnical measurements by inverse analysis. To deal with the non-uniqueness of the solution, the inverse analysis is ... [more ▼]

This study concerns the identification of parameters of soil constitutive models from geotechnical measurements by inverse analysis. To deal with the non-uniqueness of the solution, the inverse analysis is based on a genetic algorithm (GA) optimization process. For a given uncertainty on the measurements, the GA identifies a set of solutions. A statistical method based on a principal component analysis (PCA) is, then, proposed to evaluate the representativeness of this set. It is shown that this representativeness is controlled by the GA population size for which an optimal value can be defined. The PCA also gives a first-order approximation of the solution set of the inverse problem as an ellipsoid. These developments are first made on a synthetic excavation problem and on a pressuremeter test. Some experimental applications are, then, studied in a companion paper, to show the reliability of the method. [less ▲]

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See detailMatrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?
Garbacki, Nancy ULg; Di Valentin, Emmanuel ULg; Piette, Jacques ULg et al

in Pulmonary Pharmacology & Therapeutics (2009), 22(4), 267-278

Among the large matrix metalloproteinases (MMPs) family, MMP-12, also referred to as macrophage elastase, plays a significant role in chronic pulmonary pathologies characterized by an intense tissue ... [more ▼]

Among the large matrix metalloproteinases (MMPs) family, MMP-12, also referred to as macrophage elastase, plays a significant role in chronic pulmonary pathologies characterized by an intense tissue remodeling such as asthma and COPD. This review will summarize knowledge about MMP-12 structure, functions and mechanisms of activation and regulation, including potential MMP-12 modulation by microRNA. As MMP-12 is involved in many tissue remodeling diseases, efforts have been made to develop specific synthetic inhibitors. However, at this time, very few chemical inhibitors have proved to be efficient and specific to a particular MMP. The relevance of silencing MMP-12 by RNA interference is highlighted. The specificity of this approach using siRNA or shRNA and the strategies to deliver these molecules in the lung are discussed. [less ▲]

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See detailExploring the L1-L2 relationship in the L2 acquisition of prosody
Rasier, Laurent ULg; Hiligsmann, Philippe

Conference (2009)

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See detailValidation of a new pregnancy-associated glycoprotein radioimmunoassay method for the detection of early pregnancy in ewes.
Barbato, Olimpia; Melo de Sousa, Noelita ULg; Debenedetti, A. et al

in Theriogenology (2009), 72

The aim of the current study was to describe the use of a pool of different antisera raised against pregnancy-associated glycoproteins (PAGs; purified from both ovine and caprine placentas) for early ... [more ▼]

The aim of the current study was to describe the use of a pool of different antisera raised against pregnancy-associated glycoproteins (PAGs; purified from both ovine and caprine placentas) for early pregnancy diagnosis in ovine species. Sixty-three pluriparous Sarda ewes (Ovis aries) were synchronized. Blood samples were withdrawn on Days 18, 24, 26, 28, 30, and 50 after mating. These samples were assayed for progesterone (radioimmunoassay [RIA] including an extraction step) and for pregnancy-associated glycoproteins (RIA-706 and RIA-srPool). Progesterone concentrations were under 1.0ng/mL in all nonpregnant Sarda ewes. In pregnant ewes, mean progesterone concentrations ranged from 2.4ng/mL (Day 24, single pregnancies) to 4.4ng/mL (Day 28, multiple pregnancies). During all periods of examination, PAGs remained lower than 0.8ng/mL in nonpregnant ewes. On Day 18 of pregnancy, PAG concentrations could be detected in 26 of 43 (60.5%) and in 41 of 43 (95.3%) pregnant ewes using the RIA-706 and RIA-srPool methods, respectively. From Day 24 to Day 50, using both RIA methods, PAGs could be detected in all pregnant ewes. On Day 24, the best threshold for pregnancy diagnosis was obtained by use of RIA-srPool, maximal concentration in nonpregnant ewes being 0.3ng/mL and minimal concentration in pregnant ewes being 4.8ng/mL. In general, progesterone and PAG concentrations were higher in multiple pregnancies than in single pregnancies. However, because of large individual variations, single pregnancies could not be differentiated from multiple pregnancies [less ▲]

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See detailL’ACTIVATION AU SEIN DES CPAS BELGES En quête de parcours durables et de bonnes pratiques
Nisen, Laurent ULg; Chaoui, Dounia; Raeymaeckers, Peter

Report (2009)

L'étude vise d'abord à analyser le concept d'activation, celui d'activation durable, et leur opérationnalisation. Dans une seconde partie, quantitative, des trajectoires d'activation sont étudiées, sur ... [more ▼]

L'étude vise d'abord à analyser le concept d'activation, celui d'activation durable, et leur opérationnalisation. Dans une seconde partie, quantitative, des trajectoires d'activation sont étudiées, sur base des données de la Banque Carrefour de la Sécurité Sociale, selon la méthode de l'Optimal Matching Analysis. Une dernière partie, qualitative, vise à typologiser les différents CPAS belges selon leurs pratiques d'activation, et d'identifier les meilleures politiques menées par les CPAS. [less ▲]

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See detailGéopolitique du Changement Climatique
Gemenne, François ULg

Book published by Armand Colin (2009)

LE CHANGEMENT CLIMATIQUE EST AUJOURD’HUI DEVENU UN SUJET DE POLITIQUE INTERNATIONALE dont les enjeux dépassent largement la seule question écologique pour englober l’ensemble des équilibres mondiaux, et ... [more ▼]

LE CHANGEMENT CLIMATIQUE EST AUJOURD’HUI DEVENU UN SUJET DE POLITIQUE INTERNATIONALE dont les enjeux dépassent largement la seule question écologique pour englober l’ensemble des équilibres mondiaux, et notamment des rapports Nord-Sud. Le présent ouvrage, solidement référencé et assorti d’une dizaine de cartes en couleurs, examine cette dimension géopolitique du réchauffement global. Quels sont les pays responsables ou réputés tels, quels sont ceux qui en subiront l’impact le plus fortement ? Quels sont les déplacements de populations engagés ou à prévoir ? Les risques pour la sécurité internationale ? L’auteur présente également les différents mécanismes de coopération internationale mis en place, et fait le point sur l’état actuel des négociations. Nous sommes en train d’entrer dans la phase véritablement critique, voire potentiellement dramatique de la question. Ce livre permet à chacun d’en comprendre les clés et les ressorts. [less ▲]

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See detailRadiative lifetimes along even-parity J = 1, 2 Rydberg series of neutral tin
Zhang, W.; You, S.; Sun, C. et al

in European Physical Journal D -- Atoms, Molecules, Clusters & Optical Physics (2009), 55

Using the time-resolved laser-induced fluorescence (LIF) technique in a tin atomic beam, 40 natural radiative lifetimes have been measured for the even-parity J = 1 5pnp (n = 10–13, 15–19) and J = 2 5pnp ... [more ▼]

Using the time-resolved laser-induced fluorescence (LIF) technique in a tin atomic beam, 40 natural radiative lifetimes have been measured for the even-parity J = 1 5pnp (n = 10–13, 15–19) and J = 2 5pnp (n = 10–13, 15–19, 27, 31, 32), 5pnf (n = 4, 5, 9–19, 22, 23) levels along the Rydberg series and for all the 5p8p perturbing levels of neutral tin with energies in the range 52263.8 to 59099.9 cm−1. A two-step laser excitation scheme was used in the experiment. A multiconfigurational relativistic Hartree-Fock (HFR) calculation taking core-polarization effects into account has also been performed for the even-parity states for testing the ability of this approach to correctly predict the radiative properties of tin atom. Through an analysis of the energy levels structure by the multichannel quantum defect theory (MQDT), the channel admixture coefficients have been obtained and used to fit the theoretical lifetimes to the experimental ones in order to predict new values for the levels not measured. A generally good overall agreement between experimental and theoretical MQDT and HFR lifetimes has been achieved except for a few levels. [less ▲]

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See detailThe post-harvest quality of bananas is determined by pre-harvest factors
de Lapeyre de Bellaire, Luc; Chillet, Marc; Lassois, Ludivine ULg et al

Poster (2009)

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See detailRecalling semantic information about personally known faces and voices
Brédart, Serge ULg; Barsics, Catherine ULg; Hanley, Rick

in European Journal of Cognitive Psychology (2009), 21(7), 1013-1021

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See detailProduction of four amyloidogenic variants of human lysozyme as inclusion bodies in Escherichia coli
Dumont, Janice ULg; Menzer, Linda ULg; Scarafone, Natacha ULg et al

Poster (2009)

Six variants of human lysozyme (I56T, F57I, W64R, D67H, F57I/T70N and W112R/T70N) are associated with a hereditary non-neuropathic systemic amyloidosis. This disease involved an extra cellular deposition ... [more ▼]

Six variants of human lysozyme (I56T, F57I, W64R, D67H, F57I/T70N and W112R/T70N) are associated with a hereditary non-neuropathic systemic amyloidosis. This disease involved an extra cellular deposition of amyloid fibrils made of lysozyme variants in a wide range of organs such as liver, spleen and kidneys [1]. The characterisation at the molecular level of two variants, I56T and D67H, has shown that these mutations reduce the stability and more particularly the global cooperativity of the protein. Consequently, under physiologically relevant conditions, these variants can transiently populate a partially unfolded state in which the beta-domain and the C-helix are cooperatively unfolded while the rest of the protein remains native like [1]. The formation of intermolecular interactions between the regions that are unfolded in this intermediate state is likely to be a fundamental trigger of the aggregation process that ultimately leads to the formation and deposition of fibrils in tissues. In order to study the effects of the other amyloidogenic mutations on the properties of lysozyme and thus to get more insight in the mechanism of amyloid formation, it is necessary to produce them in large quantities. The D67H, I56T and F57I variants are currently produced in Aspergillus niger; the expression in this organism is, however, time consuming and the yield is very low. The attempts to use alternative systems such as Pichia pastoris [2], Saccharomyces cerevisiae, and Arabidopsis thaliana have not been conclusive so far. In this work, we have produced the four single-point lysozyme variants as inclusion bodies in Escherichia coli and explored the possibility to refold them. [1] Dumoulin & al., (2006) Acc. Chem. Res., 39, 603 - 610 [2] Kumita & al., (2006) FEBS J., 273, 711-720 [less ▲]

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See detailDes dépendances qui nous enchainent aux liens qui nous déchainent
Farbos, Julie; Servais, Catherine; Noirfalise, Stéphanie et al

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2009), 11

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See detailL’aménagement du territoire et Environnement – Problématiques et impacts
Michel, Quentin ULg

Learning material (2009)

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See detailReseña de América Latina en la “literatura mundial”, de Ignacio Sánchez-Prado (ed.)
Willson, Patricia ULg

in Iberoamericana (2009), 9(34), 223-226

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See detailCompte rendu de Heinz-Günther NESSELRATH (Hg.), "Platon. Kritias"
Gavray, Marc-Antoine ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2009), 78

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See detailLung interstitial macrophages prevent the development of respiratory allergy
Bedoret, D.; Wallemacq, Hugues ULg; Marichal, Thomas ULg et al

in Proceedings of The Keystone Symposia: Allergy and Asthma. Keystone, Colorado, USA (2009)

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See detailFormation littéraire et compétences. Notes pour un débat.
Dumortier, Jean-Louis ULg

E-print/Working paper (2009)

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