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See detailIdéologies et hégémonie : la classe dirigeante au prisme des think tanks
Geuens, Geoffrey ULg

in Quaderni : la Revue de la Communication (2009), 70 ("Think tanks, experts et pouvoirs")(automne), 69-77

This article seeks to rethink the world of think tanks as a sub-space constituting the field of power; growing links of this sub-space with media industry, economy and politics being expressed and ... [more ▼]

This article seeks to rethink the world of think tanks as a sub-space constituting the field of power; growing links of this sub-space with media industry, economy and politics being expressed and consolidated through the seamless movement of certain social agents. These representatives of the financial bourgeoisie have in fact a purely instrumental relation with liberalism, their pragmatism being well accommodated with a social discourse of public regulation. In this perspective, the denunciation of think tanks as a preferred vehicle for liberal ideology ignores the role of think tanks in the construction, reproduction and dissemination of a hegemonic discourse – that of capitalism – which uses both market idolatry and State fetishism. [less ▲]

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See detailImportance of steroid receptor coregulators for neuronal phenotype determination: Modulation of steroid action
Charlier, Thierry ULg

in Trabajos del Instituto Cajal (2009), LXXXII

Steroid receptors such as estrogen receptors alpha and beta and androgen receptors are transcription factors involved in the transcriptional regulation of a large number of target genes. Steroid-dependent ... [more ▼]

Steroid receptors such as estrogen receptors alpha and beta and androgen receptors are transcription factors involved in the transcriptional regulation of a large number of target genes. Steroid-dependent expression in the brain controls a large array of biological processes including spatial cognition, copulatory behavior and neuroprotection. The discovery of a competition, or squelching, between two different nuclear receptors introduced the notion that common cofactors might be involved in the modulation of transcriptional activity of nuclear receptors. These cofactors, which are now known as coactivators, are involved in chromatin remodeling and stabilization of the general transcription machinery. Since the characterization of the steroid receptor coactivator 1 or SRC-1, more than 100 different cofactors have been identified. Although an increasingly large amount of information has been collected about the in vitro function of these coregulatory proteins, relatively little is known regarding their physiological role in vivo, particularly in the brain. Our laboratory and others have demonstrated the importance of SRC-1 in the differentiation and activation of steroid-dependent sexual behaviors and the related neural genes. In Japanese quail, the inhibition of SRC-1 expression by intracerebroventricular antisense injections blocked the activating effects of exogenous testosterone on male sexual behaviors and the steroid-dependent vasotocine expression and increase of the median preoptic area volume defined by Nissl staining as well as by aromatase immunoreactivity. These data therefore strongly suggested that SRC-1 is required to modulate estrogen receptor dependent gene-expression. It is however interesting to note that steroid receptors and SRC-1 are not always colocalized. For example, both glial cells and neurons in the hippocampus express estrogen receptor alpha but SRC-1 is rarely observed in glia. It is therefore possible that estrogen receptor alpha in glial cell require another coactivator or set of coactivators to induce estrogen-dependent gene transcription. It has been suggested very recently that SRC-1 is associated with neuronal differentiation of neural stem cell derived from the ganglionic eminence of mouse embryos. These stem cells differentiating into glial cell (GFAP-positive) did not express SRC-1. The presence of a specific coactivator could therefore determine a specific cell phenotype (neuronal vs glial). Another coactivator, the coactivator-associated arginine methyl transferase 1 or CARM-1 seems to be important to keep progenitor cells in a dividing state. The inhibition of CARM-1 expression leads to neuronal differentiation. Neurogenesis can therefore offers an excellent model to define the spatio-temporal role of different coactivators. It is indeed possible to study a subset of coactivators associated to various stages phenotype determination (proliferation vs. differentiation). The study of neurogenesis in the dentate gyrus of the hippocampus in female adult rats shows that around 40 % of proliferative cells express SRC-1 or CARM-1. Interestingly, 70% of proliferative cells express SRC-1 but only a very few cells (<5%) express CARM-1. We are currently investigating the temporal pattern of expression of these two coactivators during the neurogenesis in the hilus and dentate gyrus. The expression of the coactivators CARM-1 and SRC-1 is analyzed in proliferating and differentiating cells. We expect that proliferating and differentiating cells will differentially express the two coactivators. It seems that the presence of a precise subset of coactivators could help defining the phenotype of the cell by modulating a specific downstream pathway after steroid receptor activation. The very large number of coactivators and their association into preformed complexes potentially allows the determination of hundreds of different phenotypes. The study of the expression of the coactivator and their function in vivo is required to fully understand steroid action and specificity in the brain. [less ▲]

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See detailPre-study and in-study validation of an ultra-high pressure LC method coupled to tandem mass spectrometry for off-line determination of oxytetracycline in nasal secretions of healthy pigs.
Bimazubute, Marcel Aimé ULg; Rozet, Eric ULg; Dizier, Isabelle ULg et al

in Journal of Chromatography. B : Analytical Technologies in the Biomedical & Life Sciences (2009), 877(23), 2349-57

In order to quantify oxytetracycline (OTC) in nasal secretions of healthy pigs after intramuscular injection of OTC at doses of 10, 20 and 40 mg/kg bodyweight, an original method based on ultra-high ... [more ▼]

In order to quantify oxytetracycline (OTC) in nasal secretions of healthy pigs after intramuscular injection of OTC at doses of 10, 20 and 40 mg/kg bodyweight, an original method based on ultra-high pressure liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) was developed and fully validated. Sample preparation consisted in protein precipitation preceded by the addition of a releasing protein reagent. Metacycline (MTC) was used as internal standard. Separation was carried out at 65 degrees C in the gradient elution mode on a short analytical column filled with Acquity BEH C(18) stationary phase. The mobile phase consisted in a mixture of water and acetonitrile containing 1 mM of oxalic acid and 0.1% (v/v) of formic acid. The triple quadrupole mass spectrometer operated in the positive electrospray ionization mode; OTC and MTC were detected using multiple reaction monitoring. The pre-study and in-study validation of this bioanalytical method was performed by applying a novel strategy based on total measurement error and accuracy profiles. The maximum risk of observing future measurements falling outside the acceptance limits during routine as well as the measurements uncertainty were also estimated. [less ▲]

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See detailLes corrélats neuronaux de l’acquisition et de la consolidation en mémoire dans la maladie d’Alzheimer et le trouble de mémoire isolé
Genon, Sarah ULg; Collette, Fabienne ULg; Moulin, Christopher et al

in Revue Neurologique (2009), 165

Introduction : Un déficit en mémoire épisodique est caractéristique dans la maladie d’Alzheimer (AD) et chez les patients âgés présentant une altération cognitive légère (MCI). Cette altération peut ... [more ▼]

Introduction : Un déficit en mémoire épisodique est caractéristique dans la maladie d’Alzheimer (AD) et chez les patients âgés présentant une altération cognitive légère (MCI). Cette altération peut s’expliquer par un déficit d’acquisition et/ou un déficit de consolidation. Toutefois, les modifications cérébrales responsables de ces déficits ne sont pas encore parfaitement élucidées. L’objectif de notre étude était de mettre en relation le profil d’apprentissage déficitaire de ces patients avec leur métabolisme cérébral au repos. Méthode : L’épreuve du California Verbal Learning Test (CVLT) a été administrée à 51 patients AD, 18 patients MCI qui sont restés stables (suivi longitudinal de 18 mois, MCI-S), 16 patients MCI qui ont développé la maladie d’Alzheimer (MCI-C) durant les 18 mois de suivi et 12 participants de contrôle. La mesure d’acquisition est la proportion moyenne de gain à travers les 5 essais d’apprentissage du CVLT. La mesure de consolidation est la proportion totale de pertes à travers ces 5 essais. La mesure du métabolisme cérébral au repos a été effectuée en tomographie par émission de positions (18FDG-TEP). Les mesures de corrélation cognitivo-métabolique ont été réalisées au moyen du logiciel SPM8 (p non-corrigé avec hypothèse a priori <0.001). Résultats : Les groupes AD et MCI-C ont un gain moyen moindre que les groupes MCI-S et contrôles. L’ampleur du gain inter-essais est positivement corrélée à l’activité métabolique au niveau de l’hippocampe postérieur chez les patients AD, à l’activité pariétale inférieure chez les patients MCI-S, et à l’activité frontale postérieure dans le groupe contrôle. Par ailleurs, le groupe AD présente plus de pertes inter-essais que les trois autres groupes. Toutefois, aucune corrélation significative n’apparait entre le total des pertes inter-essais et le métabolisme cérébral. Discussion : Ces données suggèrent que les patients AD, même à un stade très précoce (MCI-C) présentent un déficit d’acquisition de l’information. Ce déficit pourrait être sous-tendu par des perturbations métaboliques dans les réseaux d’apprentissage fronto-pariétaux et hippocampique. Il existe de plus un déficit de consolidation inter-essais spécifique aux patients AD mais ce déficit n’est corrélé à aucune région cérébrale au seuil statistique utilisé. [less ▲]

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See detaildinanderie
George, Philippe ULg

in Dictionnaire d’Histoire de l’art du Moyen Age occidental (2009)

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See detailEnergising an exchange network between trainers in health promotion in the long term
Giot, Catherine ULg; Gosselain, Yves; Vanesse, Catherine et al

in Archives of Public Health (2009), 67(Supplement 2), 27-28

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See detailPractical feeding of sugar gliders (Petaurus breviceps)
Guillon, Leslie; Hornick, Jean-Luc ULg; Istasse, Louis ULg et al

in Mussa, P. P.; Nery, J.; Schiavone, A. (Eds.) et al Congress Proceedings 13t h Congress of the ESVCN (2009)

Communication relatant un essai d'alimentation pratique de sugar glider en captivité

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See detailRespiratory inflammation in endurance horses
Van Erck, Emmanuelle ULg; Art, Tatiana ULg

in Tessier, Caroline; Gerber, Vincent (Eds.) Abstract book: 4th World Equine Airways Symposium (WEAS) (2009)

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See detailSciences, technologies et société : Guide pratique en 250 questions
Wautelet, Michel; Duvivier, Damien; Ozer, Pierre ULg

Book published by De Boeck - 3e édition (2009)

Nous vivons incontestablement dans une société où les sciences et les technologies jouent un rôle essentiel. Étant donné le nombre grandissant de questions cruciales, possédant un ou plusieurs aspects ... [more ▼]

Nous vivons incontestablement dans une société où les sciences et les technologies jouent un rôle essentiel. Étant donné le nombre grandissant de questions cruciales, possédant un ou plusieurs aspects technoscientifiques, il est nécessaire que chacun puisse se faire une idée, personnelle, mais justifiée. Mais, entre le spécialiste, le technicien et le citoyen, une étape est généralement manquante. Lorsqu’on essaye d’en savoir plus sur une technologie donnée ou un problème scientifique complexe pour essayer d’effectuer des calculs d’ordres de grandeur, on trouve peu de données utiles. C’est le point de départ de cet ouvrage : associer des connaissances suffisantes de notions fondamentales de sciences à des données techniques afin d’en savoir plus sur une technologie donnée ou un problème scientifique complexe C’est donc au travers de 250 questions et réponses que le lecteur pourra appréhender des thématiques aussi diverses que le bâtiment, l’informatique, les énergies ou encore les transports. Ce livre s’adresse à plusieurs catégories de lecteurs. D’abord, au citoyen désireux de se faire une opinion sur certains thèmes à caractère technoscientifique. Au curieux aussi, qui veut savoir sur quoi reposent différentes technologies, quels sont leurs liens et implications avec la société. Aux enseignants, qui trouveront des données numériques, des formules de base pour illustrer leur cours de sciences. La volonté de cet ouvrage est de démontrer qu’il est possible d’appréhender des problèmes de société majeurs, à partir de notions scientifiques vues dans le secondaire. N’est-ce pas une voie à suivre pour recréer une dynamique nouvelle dans l’enseignement des sciences, et pour montrer aux enseignants et aux jeunes l’utilité des cours de sciences ? Ce livre s’adresse aussi à tous ceux qui ont mission d’informer le public. Ils trouveront ici des données, des raisonnements utiles pour, selon leurs propres sources, réévaluer certains chiffres officiels, analyser certains discours techniques ou politiques à l’aide de faits scientifiques et techniques. La plupart des réponses aux 250 questions qui suivent sont donc accessibles au plus grand nombre, ce qui fait de cet ouvrage un guide pratique à l’usage de tous ! [less ▲]

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See detailDevelopment of a strategy to study toxicodynamic of pollutants in spawning sea turtles
Dyc, Christelle ULg; Bouquegneau, Jean-Marie ULg; Gillet, Marie-Claire ULg et al

in Proceedings of the 29th Annual Symposium on Sea Turtle Biology and Conservation (2009)

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See detailFrom subspace learning to distance learning: a geometrical optimization approach
Meyer, Gilles ULg; Journée, Michel; Bonnabel, Silvère et al

in Proceedings of the 2009 IEEE Workshop on Statistical Signal Processing (SSP2009) (2009)

In this paper, we adopt a differential-geometry viewpoint to tackle the problem of learning a distance online. As this prob- lem can be cast into the estimation of a fixed-rank positive semidefinite (PSD ... [more ▼]

In this paper, we adopt a differential-geometry viewpoint to tackle the problem of learning a distance online. As this prob- lem can be cast into the estimation of a fixed-rank positive semidefinite (PSD) matrix, we develop algorithms that ex- ploits the rich geometry structure of the set of fixed-rank PSD matrices. We propose a method which separately updates the subspace of the matrix and its projection onto that subspace. A proper weighting of the two iterations enables to continu- ously interpolate between the problem of learning a subspace and learning a distance when the subspace is fixed. [less ▲]

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See detailEmerging Patterns of Depoliticization and Engagement to Inform the Future of Science and Technology Studies: A Case Study in Nanotechnologies
Thoreau, François ULg

Conference (2009)

In this paper, we address the issue of the future of a particular field of research in social science: Science and Technology Studies (STS). Although this is a very young research field, its history is ... [more ▼]

In this paper, we address the issue of the future of a particular field of research in social science: Science and Technology Studies (STS). Although this is a very young research field, its history is already diverse and its evolutions are fastly moving on. Its rapid expansion and its characteristic feature of crossing disciplinary boundaries are making it an interesting case to study, which takes a particular place in the overall history – and future – of social changes. As we shall indicate, STS have an increasing committment for the resolution of sociotechnical controversies. In this paper, we problematise this particular position by underlying the implicit politics of STS research and how they will shape the future of that particular field. Our approach is threefold. First, we give a brief overview of the history of the field and we point out the main evolutions since the developement of the Social Construction of Technology approach (SCOT) in the 1980s that long influenced the field. By doing so, we underline the epistemological critical tradition that gave the field some of its particularities that we address. We show how this tradition brought important insights of “political” nature within the development of the field. Second, our ambition is to highlight new patterns of evolution of the STS field, emphasizing the trends towards both a greater depoliticisation and a more engaged research. By “depoliticisation”, we intend to analyse the dynamics of institutionalisation of the field which adopts resources and tools to legitimate itself among the social scientific community. By “engaged” research, we will explore the evolutions of the STS field as inherently political. The field does have an implicit statement in favor of changing social order and an increasing willingness to actually influence that social change. In that respect, research projects in STS often have underlying politics, as we shall demonstrate. Third, we give a concrete example of these new patterns occuring, relying on the growing importance of nanotechnologies, both in the STS literature and research projects. We consider this case study to be intertwined with the development of STS as a field of research. In that sense, we stress that nanotechnologies happened to be a powerful tool for legitimation for the STS community. Therefore, we — as STS scholars — suggest instrumentalizing the interest we have in nanotechnologies in order to observe the evolutions of our field of research. Then, nanotechnologies will constitute an interesting ground to perform a test that will show depoliticisation and engagement as patterning the STS field. [less ▲]

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See detailTraitement automatique des langues et langues anciennes
Denooz, Joseph ULg; Rosmorduc, Serge

in Traitement automatique des langues (2009), 50

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See detailImidazol(in)ium-2-carboxylates as N-heterocyclic carbene precursors for the synthesis of second generation ruthenium metathesis catalysts
Sauvage, Xavier ULg; Demonceau, Albert ULg; Delaude, Lionel ULg

in Advanced Synthesis & Catalysis (2009), 351(11-12), 2031-2038

Five well-known ruthenium-N-heterocyclic carbene (NHC) catalysts for olefin metathesis and related reactions, including the second generation Grubbs and Hoveyda-Grubbs catalysts, were prepared by ... [more ▼]

Five well-known ruthenium-N-heterocyclic carbene (NHC) catalysts for olefin metathesis and related reactions, including the second generation Grubbs and Hoveyda-Grubbs catalysts, were prepared by phosphane exchange between first generation ruthenium-benzylidene or indenylidene complexes and NHCs generated in situ upon thermolysis of imidazol(in)ium-2-carboxylates. Because N-heterocyclic carbene -carbon dioxide adducts (NHC · CO2) are stable zwitterionic compounds that can be stored and handled with no particular precautions, this procedure is particularly attractive from a practical point of view. Reaction courses were conveniently monitored by 31P NMR spectroscopy and the experimental conditions were carefully adjusted to obtain high yields of pure products within short periods of time. [less ▲]

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See detailDetection and Correction of Outliers for Fatty Acids Contents Measured by Mid-Infrared Spectrometry Using Random Regression Test-Day Models
Soyeurt, Hélène ULg; Dardenne, Pierre; Gengler, Nicolas ULg

in Book of Abstracts of the 60th Annual Meeting of the European Association for Animal Production (2009)

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See detailCritical role of tryptophan 154 for the activity and stability of class D beta-lactamases.
Baurin, Stephane; Vercheval, Lionel ULg; Bouillenne, Fabrice ULg et al

in Biochemistry (2009), 48(47), 11252-63

The catalytic efficiency of the class D beta-lactamase OXA-10 depends critically on an unusual carboxylated lysine as the general base residue for both the enzyme acylation and deacylation steps of ... [more ▼]

The catalytic efficiency of the class D beta-lactamase OXA-10 depends critically on an unusual carboxylated lysine as the general base residue for both the enzyme acylation and deacylation steps of catalysis. Evidence is presented that the interaction between the indole group of Trp154 and the carboxylated lysine is essential for the stability of the posttranslationally modified Lys70. Substitution of Trp154 by Gly, Ala, or Phe yielded noncarboxylated enzymes which displayed poor catalytic efficiencies and reduced stability when compared to the wild-type OXA-10. The W154H mutant was partially carboxylated. In addition, the maximum values of k(cat) and k(cat)/K(M) were shifted toward pH 7, indicating that the carboxylation state of Lys70 is dependent on the protonation level of the histidine. A comparison of the three-dimensional structures of the different proteins also indicated that the Trp154 mutations did not modify the overall structures of OXA-10 but induced an increased flexibility of the Omega-loop in the active site. Finally, the deacylation-impaired W154A mutant was used to determine the structure of the acyl-enzyme complex with benzylpenicillin. These results indicate a role of the Lys70 carboxylation during the deacylation step and emphasize the importance of Trp154 for the ideal positioning of active site residues leading to an optimum activity. [less ▲]

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See detailDirect regeneration of rattan seedlings from apical meristem and axillary bud explants
Kouakou, L. K.; Zoro Bi, I. A.; Kouakou, T. H. et al

in Belgian Journal of Botany (2009), 142(1), 60-67

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