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See detailLong-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial.
Kahan, Andre; Uebelhart, Daniel; De Vathaire, Florent et al

in Arthritis and Rheumatism (2009), 60(2), 524-33

OBJECTIVE: To assess the long-term effects of chondroitins 4 and 6 sulfate (CS) on the radiographic progression of, and symptom changes associated with, knee osteoarthritis (OA). METHODS: We performed an ... [more ▼]

OBJECTIVE: To assess the long-term effects of chondroitins 4 and 6 sulfate (CS) on the radiographic progression of, and symptom changes associated with, knee osteoarthritis (OA). METHODS: We performed an international, randomized, double-blind, placebo-controlled trial in which 622 patients with knee OA were randomly assigned to receive either 800 mg CS (n = 309 patients) or placebo (n = 313 patients) once daily for 2 years. Radiographs of the target knee, using the Lyon schuss view, were obtained at the time of enrollment and at 12, 18, and 24 months. The minimum joint space width (JSW) of the medial compartment of the tibiofemoral joint was assessed by digital image analysis. The primary outcome was the loss in minimum JSW over 2 years. RESULTS: The intent-to-treat analysis demonstrated a significant reduction (P < 0.0001) in minimum JSW loss in the CS group (mean +/- SEM -0.07 +/- 0.03 mm) as compared with the placebo group (-0.31 +/- 0.04 mm). The percentage of patients with radiographic progression > or =0.25 mm was significantly reduced in the CS group compared with the placebo group (28% versus 41% [P < 0.0005]; relative risk reduction 33% [95% confidence interval 16-46%]). The number of patients needed to treat was 8 (95% confidence interval 5-17). Pain improved significantly faster in the CS group than in the placebo group (P < 0.01). There were no differences in safety between groups. CONCLUSION: The long-term combined structure-modifying and symptom-modifying effects of CS suggest that it could be a disease-modifying agent in patients with knee OA. [less ▲]

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See detailZoledronic acid and risedronate in the prevention and treatment of glucocorticoid-induced osteoporosis (HORIZON): a multicentre, double-blind, double-dummy, randomised controlled trial.
Reid, David M; Devogelaer, Jean-Pierre; Saag, Kenneth et al

in Lancet (2009), 373(9671), 1253-63

BACKGROUND: Persistent use of glucocorticoid drugs is associated with bone loss and increased fracture risk. Concurrent oral bisphosphonates increase bone mineral density and reduce frequency of vertebral ... [more ▼]

BACKGROUND: Persistent use of glucocorticoid drugs is associated with bone loss and increased fracture risk. Concurrent oral bisphosphonates increase bone mineral density and reduce frequency of vertebral fractures, but are associated with poor compliance and adherence. We aimed to assess whether one intravenous infusion of zoledronic acid was non-inferior to daily oral risedronate for prevention and treatment of glucocorticoid-induced osteoporosis. METHODS: This 1-year randomised, double-blind, double-dummy, non-inferiority study of 54 centres in 12 European countries, Australia, Hong Kong, Israel, and the USA, tested the effectiveness of 5 mg intravenous infusion of zoledronic acid versus 5 mg oral risedronate for prevention and treatment of glucocorticoid-induced osteoporosis. 833 patients were randomised 1:1 to receive zoledronic acid (n=416) or risedronate (n=417). Patients were stratified by sex, and allocated to prevention or treatment subgroups dependent on duration of glucocorticoid use immediately preceding the study. The treatment subgroup consisted of those treated for more than 3 months (272 patients on zoledronic acid and 273 on risedronate), and the prevention subgroup of those treated for less than 3 months (144 patients on each drug). 62 patients did not complete the study because of adverse events, withdrawal of consent, loss to follow-up, death, misrandomisation, or protocol deviation. The primary endpoint was percentage change from baseline in lumbar spine bone mineral density. Drug efficacy was assessed on a modified intention-to-treat basis and safety was assessed on an intention-to-treat basis. This trial is registered with ClinicalTrials.gov, number NCT00100620. FINDINGS: Zoledronic acid was non-inferior and superior to risedronate for increase of lumbar spine bone mineral density in both the treatment (least-squares mean 4.06% [SE 0.28] vs 2.71% [SE 0.28], mean difference 1.36% [95% CI 0.67-2.05], p=0.0001) and prevention (2.60% [0.45] vs 0.64% [0.46], 1.96% [1.04-2.88], p<0.0001) subgroups at 12 months. Adverse events were more frequent in patients given zoledronic acid than in those on risedronate, largely as a result of transient symptoms during the first 3 days after infusion. Serious adverse events were worsening rheumatoid arthritis for the treatment subgroup and pyrexia for the prevention subgroup. INTERPRETATION: A single 5 mg intravenous infusion of zoledronic acid is non-inferior, possibly more effective, and more acceptable to patients than is 5 mg of oral risedronate daily for prevention and treatment of bone loss that is associated with glucocorticoid use. [less ▲]

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See detailSub-Rayleigh quantum imaging using single-photon sources
Thiel, C.; Bastin, Thierry ULg; von Zanthier, J. et al

in Physical Review. A (2009), 80

We propose a technique capable of imaging a distinct physical object with sub-Rayleigh resolution in an ordinary far-field imaging setup using single-photon sources and linear optical tools only. We ... [more ▼]

We propose a technique capable of imaging a distinct physical object with sub-Rayleigh resolution in an ordinary far-field imaging setup using single-photon sources and linear optical tools only. We exemplify our method for the case of a rectangular aperture and two or four single-photon emitters obtaining a resolution enhanced by a factor of 2 or 4, respectively. [less ▲]

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See detailLe concept de fonction au fil du temps
Bair, Jacques ULg; Henry, Valérie ULg

in Losanges (2009), 5

Vous souhaitons évoquer quelques étapes marquantes dans l'étude du concept de fonction. Nous verrons comment les mathématiciens ont pressenti, puis créé et développé ce concept. Nous dégagerons de ce ... [more ▼]

Vous souhaitons évoquer quelques étapes marquantes dans l'étude du concept de fonction. Nous verrons comment les mathématiciens ont pressenti, puis créé et développé ce concept. Nous dégagerons de ce parcours certaines idées pour l'enseignement. [less ▲]

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See detailContinuous formulation for bottom friction in free surface flows modelling
Machiels, Olivier ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in River Basin Management V (2009)

Bottom friction modelling is an important step in river flows computation with 1D or 2D solvers. It is usually performed using empirical laws established for uniform flow conditions or a modern approach ... [more ▼]

Bottom friction modelling is an important step in river flows computation with 1D or 2D solvers. It is usually performed using empirical laws established for uniform flow conditions or a modern approach based on turbulence analysis. Following the definition of the flow validity field of the main friction laws proposed in the literature, an original continuous formulation has been developed. It is suited to model river flows with a wide range of properties (water depth, discharge, roughness…). The efficiency of this new formulation, theoretically established and numerically adjusted, is demonstrated through various practical applications. [less ▲]

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See detailCushing disease : Pituitary microsurgery on hormonal balance
Stevenaert, Achille ULg; Vroonen, Laurent ULg; Perrin, G. et al

in European Neuroendocrine Association - Workshop : Novel insights in the management of Cushing's syndrome (2009)

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See detailMécanismes de l'anesthésie générale: apport de l'imagerie fonctionnelle
Boveroux, Pierre ULg; Bonhomme, Vincent ULg; Kirsch, Murielle ULg et al

in Revue Médicale de Liège (2009), 64(Synthèse 2009), 36-41

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See detailFondements de gestion financière: manuel et applications
Corhay, Albert ULg; Mbangala, Mapapa ULg

Book published by Les Editions de l'Université de Liège - 4ème édition, revue et corrigée (2009)

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See detailWhen morphology and molecules tell us different stories: a case-in-point with Leptodon corsicus, a new and unique endemic moss species from Corsica
Sotiaux A.; Enroth, J.; Quandt, D. et al

in Journal of Bryology (2009), 31

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See detailSleep and Sleep States: PET activation patterns
Dang Vu, Thien Thanh ULg; Desseilles, Martin ULg; Peigneux, Philippe ULg et al

in Squire, Larry (Ed.) Encyclopedia of Neuroscience (2009)

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See detailLa tutelle sur les marchés publics en Région wallonne
Durviaux, Ann-Lawrence ULg

Conference given outside the academic context (2009)

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See detailApport de la neuro-imagerie fonctionnelle à l'étude de la douleur
Fontaine, Robert ULg; Vanhaudenhuyse, Audrey ULg; Demertzi, Athina ULg et al

in Revue du Rhumatisme (2009), 76

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See detailThe Roof Shape
Hoffsummer, Patrick ULg

in Hoffsummer, Patrick (Ed.) Roof Frames from the 11th to the 19th Century: Typology and Development in Northern France and in Belgium: Analysis of CRMH Documentation (2009)

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See detailMonitoring an Odour in the Environment with an Electronic Nose: Requirements for the Signal Processing
Romain, Anne-Claude ULg; Nicolas, Jacques ULg

in Gutierrez, Agustin; Marco, S. (Eds.) Biologically Inspired Signal Processing for Chemical Sensing (2009)

Artificial olfaction system (the so-called electronic nose) is a very promising tool to monitor the malodour in the field. Usual odour measurement techniques use human olfaction or analytical techniques ... [more ▼]

Artificial olfaction system (the so-called electronic nose) is a very promising tool to monitor the malodour in the field. Usual odour measurement techniques use human olfaction or analytical techniques. The first category represents the real odour perception but is not applicable to measure in continuous bad odours in the field. The second class of techniques gives the composition of the mixture but not the global information representative of the odour perception. The e-nose has the potentialities to combine “the odour perception” and the “monitoring in the field”. However to be able to reach this goal, the signal processing has to be adapted to work in complex environment. We have more than teen years experiments in the measure of environmental malodours in the field and the paper presents the minimal requirements that we consider essential for artificial olfaction system to become successful for this application. [less ▲]

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See detailStructural, Magnetic and Mössbauer Spectral Study of the Electronic Spin-state Transition in {Fe[HC(3-Mepz)2(5-Mepz)]2}(BF4)2
Reger, Daniel; Elgin, J.; Foley, E. et al

in Inorganic Chemistry (2009), 48

The complex {Fe[HC(3-Mepz)2(5-Mepz)]2}(BF4)2 (pz = pyrazolyl ring) has been prepared by the reaction of HC(3-Mepz)2(5-Mepz) with Fe(BF4)2·6H2O. The solid state structures obtained at 294 and 150 K show a ... [more ▼]

The complex {Fe[HC(3-Mepz)2(5-Mepz)]2}(BF4)2 (pz = pyrazolyl ring) has been prepared by the reaction of HC(3-Mepz)2(5-Mepz) with Fe(BF4)2·6H2O. The solid state structures obtained at 294 and 150 K show a distorted iron(II) octahedral N6 coordination environment with the largest deviations arising from the restrictions imposed by the chelate rings. At 294 K the complex is predominately high-spin with Fe–N bond distances averaging 2.14 Å, distances that are somewhat shorter than expected for a purely high-spin iron(II) complex because of the presence of an admixture of ca. 70 (I get 80 from both mag and X-ray, 3/15, where 3 is the subtraction of 2.14 and 2.17 and 15 1.99 and 2.14 and from Figure 3b) percent high-spin and 30 (20) percent low-spin iron(II). At 294 K the twisting of the pyrazolyl rings from the ideal C3v symmetry averages only 2.2o, a much smaller twist than has been observed previously in similar complexes. At 150 K the Fe–N bond distances average 1.99 Å, indicative of an almost fully low-spin iron(II) complex; the twist angle is only 1.3o, as expected for a complex with these Fe–N bond distances. The magnetic properties show that the complex undergoes a gradual change from low-spin iron(II) below 85 K to high-spin iron(II) at 400 K. The 4.2 to 60 K Mössbauer spectra correspond to a fully low-spin iron(II) complex but, upon further warming, the iron(II) begins to undergo spin-state relaxation on the Mössbauer time scale such that, at 155 and 315 K, the complex is 7.5 and 65 percent high-spin in the absence of any adjustment for the differing low-spin and high-spin recoil-free fractions. I would replace the previous sentence with the red. I see no reason to give the % from the Mössbauer in the abstract as it is likely a bit low as discussed in detail – neither the mag data nor X-ray data have the recoil issue. The last sentence in the abstract is the key information. OK The 4.2 to 60 K Mössbauer spectra correspond to a fully low-spin-iron(II) complex but, upon further warming above 85 K the iron(II) begins to undergo spin-state relaxation between the low- and high-spin forms on the Mössbauer time scale. At 155 and 315 K the complex exhibits spin-state relaxation rates of 0.36 and 7.38 MHz, respectively, and an Arrhenius plot of the logarithm of the relaxation rate yields an activation energy of 670 ± 40 cm–1 for the spin-state relaxation. [less ▲]

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See detailNonlinear Targeted Energy Transfer in Mechanical and Structural Systems I
Vakakis, Alexander F.; Gendelman, O. V.; Bergman, L. A. et al

Book published by Springer (2009)

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See detailEntraînement excentrique des rotateurs d'épaule
Forthomme, Bénédicte ULg; Chague, Lucie ULg; Crielaard, Jean-Michel ULg et al

in Croisier, Jean-Louis; Codine, Philippe (Eds.) Exercice musculaire excentrique (2009)

In this study, we have investigated the influence of the installation on the dynamometer and of the mode of contraction used during a rotator cuff muscle training. 24 subjects were divided into 3 groups ... [more ▼]

In this study, we have investigated the influence of the installation on the dynamometer and of the mode of contraction used during a rotator cuff muscle training. 24 subjects were divided into 3 groups. Two groups of 8 subjects performed a training of the Internal Rotators (IR) in concentric mode (60°/s and 240°/s) and of the External Rotators in eccentric mode (60°/s). The first group was trained at 45° of abduction; the second was trained at 90° of abduction. The third group did not perform any shoulder training. All patients were assessed thanks to the isokinetic device ((3) x 60°/s concentric – (5) x 240°/s concentric – (4) x 60°/s eccentric) before and after training. Only the group trained at 45° of abduction increased the isokinetic maximal peak torque (+ p) in concentric mode during the second isokinetic assessment. No subject showed improvement through the eccentric exercise. They also improved the throw of the ball (+ 8.5 %). Possible feeling of discomfort and signs of subacromial conflict explained that no progression was recorded after training at 90° of abduction. Likewise, the eccentric mode would major the inhibition limiting the strength increase. Even if 90° of abduction seems more specific for assessment, 45° of abduction is more suitable for training. [less ▲]

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