Circulating insulin antibodies: influence of continuous subcutaneous or intraperitoneal insulin infusion, and impact on glucose control.
Radermecker, Régis ; ; Scheen, André
in Diabetes/Metabolism Research & Reviews (2009)
The purification of animal insulin preparations and the use of human recombinant insulin have markedly reduced the incidence, but not completely suppressed, the development of anti-insulin antibodies (IAs ... [more ▼]
The purification of animal insulin preparations and the use of human recombinant insulin have markedly reduced the incidence, but not completely suppressed, the development of anti-insulin antibodies (IAs). Advances in technologies concerning the mode of delivery of insulin, i.e. continuous subcutaneous insulin infusion (CSII), continuous peritoneal insulin infusion (CPII) and more recently inhaled insulin administration, appear to significantly increase circulating levels of immunoglobulin G (IgG) anti-IAs in diabetic patients. However, the increase is usually moderate and mostly transient as compared to previous observations with poorly purified animal insulin preparations. The clinical impact of these circulating anti-IAs remains unclear. Nevertheless, several studies have suggested that antibodies could retard insulin action, leading to a worsening of postprandial hyperglycaemia and/or serve as a carrier, thus leading to unexpected hypoglycaemia. CPII may be associated with more marked and sustained increase in IAs levels, possibly related to the use of an unstable insulin and the formation of immunogenic aggregates of insulin. The possible clinical consequences of these high levels of IAs remain to be evaluated because a low-glucose morning syndrome or severe insulin resistance with ketone bodies production have been reported in some cases. In conclusion, even if CSII and CPII may promote the development of circulating IAs, this increase does not lead to immunological insulin resistance, compared to that previously described with animal non-purified insulin preparations, and seems to have only marginal influence on blood glucose control or complications in most diabetic patients. [less ▲]Detailed reference viewed: 49 (8 ULg)
La retraite anticipée des salariés en Belgique
Lefebvre, Mathieu ; Paszukiewicz, Alexis ;
in Revue Economique (2009)
Cet article propose une analyse de la cessation anticipée d’activité des salariés du secteur privé en Belgique. Contrairement aux études précédentes (Pestieau et Stijns  et Dellis et al. [2004 ... [more ▼]
Cet article propose une analyse de la cessation anticipée d’activité des salariés du secteur privé en Belgique. Contrairement aux études précédentes (Pestieau et Stijns  et Dellis et al. ), notre étude se base sur un modèle structurel d’offre de travail. Ceci a l’avantage de pouvoir être utilisé afin de tester l’impact de réformes potentielles visant à augmenter l’activité des plus âgés. Nos résultats montrent qu’il y a une réelle préférence pour le loisir aux âges avancés mais que les incitants au départ anticipé contenus dans les systèmes de sécurité social jouent un rôle. En particulier, l’accès libre à différents régimes de revenus de remplacement à des âges relativement jeunes constitue un frein à la continuation de l’activité. [less ▲]Detailed reference viewed: 202 (20 ULg)
Magnetic susceptibility evolution and sedimentary environments on carbonate platform sediments and atolls, comparison of the Frasnian from Belgium and Alberta, Canada
Da Silva, Anne-Christine ; ; et al
in Sedimentary Geology (2009), 214
Magnetic susceptibility (MS) measurements on carbonate rocks are considered as a proxy for impurities delivered to the carbonate environments. In the absence of strong climatic or tectonic variations ... [more ▼]
Magnetic susceptibility (MS) measurements on carbonate rocks are considered as a proxy for impurities delivered to the carbonate environments. In the absence of strong climatic or tectonic variations, bulk MS values have been linked to sea level variations, because sea-level fall increases clastic supply and therefore increases magnetic mineral deposition. In this paper we explore the relationship between the average magnitude of bulk MS, with shallowing-up sequences and facies evolution in different Devonian carbonate complexes. Similarities and differences between these parameters have been scrutinized in carbonate attached platform and detached platforms (mounds and/or atolls) from Belgium and Canada. In the carbonate attached platforms from Belgium and Canada, the MS patterns are directly related to depositional environment. Mean MS values increase from the most distal towards the most proximal facies and towards the top of the majority of fourth-order shallowing-up sequences. These trends are in agreement with theoretical background (MS increases with regression). In the Belgian detached platform, the average MS pattern generally shows an opposite behaviour of that observed in the attached carbonate platforms. Average MS decreases towards the most proximal facies and towards the top of a majority of the fourth-order shallowing-up sequences. This behaviour can be explained by the influence of sedimentary rate and water agitation during deposition. A high sedimentary rate will dilute the magnetic minerals in the atoll facies and the highwater agitation during deposition may be expected to have prevented the deposition of the magnetic grains. So, the combination of these two effects will result in the observed low values in the atoll crown and lagoonal facies. In the Canadian detached platform, MS is mainly negative. This means that the limestones are very pure. The technique does not appear to be appropriate in these rocks. The variations of average MS behaviour by platform type can imply difficulties in correlating carbonates from different settings. A comparison of time equivalent mound and platform deposits shows that after an important regressive surface, the MS values are increasing for the platform deposits and decreasing for the mound. So MS evolution can be in complete opposition (caused by highly different sedimentary rates) in different depositional settings. The MS signal preserved in carbonate rocks is probably mainly related to 1) varying clastic supplies; 2) varying carbonate accumulation rates (dilution of the magnetic minerals by high carbonate production) and 3) potentially diagenesis. [less ▲]Detailed reference viewed: 117 (8 ULg)
Evaluation de la qualité biologique des masses d’eau naturelles, artificielles et fortement modifiées Indicateurs macrophytes
Sossey Alaoui, Khadija
Report (2009)Detailed reference viewed: 17 (2 ULg)
Perenniporiella chaquenia sp. nov. and further notes on Perenniporiella and its relationships with Perenniporia (poriales, basidiomycota).
; ; Castillo Cabello, Gabriel et al
in Mycologia (2009), 101(5), 657-73
Perenniporiella chaquenia sp. nov. is described from Argentina. New records of P. pendula and P. micropora are discussed. A key to Perenniporiella species is presented. Preliminary phylogenetic ... [more ▼]
Perenniporiella chaquenia sp. nov. is described from Argentina. New records of P. pendula and P. micropora are discussed. A key to Perenniporiella species is presented. Preliminary phylogenetic relationships of Perenniporiella are inferred from parsimony and Bayesian analysis of a combined set of DNA sequence data (nuclear ribosomal partial LSU and ITS). It demonstrated that Perenniporiella forms a well resolved monophyletic clade distantly related to Perenniporia s.s. It also clearly showed that within Perenniporia as usually conceived other morphologically homogeneous group of taxa, such as the P. ochroleuca or P. vicina alliances, form well resolved clades, which could be recognized as distinct genera. The differentiation of the hyphal system and the basidiospores morphology are outlined as critical features for the definition of genera in the Perenniporia complex. [less ▲]Detailed reference viewed: 23 (1 ULg)
Dislocation et thématisation en français et en néerlandais - L1 et L2
Scientific conference (2009)Detailed reference viewed: 33 (2 ULg)
Systéme d'évaluation génétique pour les verrats Piétrain en croisement en Wallonie
Dufrasne, Marie ; ; Hammami, Hedi et al
Computer development (2009)Detailed reference viewed: 64 (26 ULg)
Pulse pressure and cardiovascular autonomic neuropathy according to duration of type 1 diabetes.
Philips, Jean-Christophe ; Marchand, Monique ; Scheen, André
in Diabetes/Metabolism Research & Reviews (2009)
BACKGROUND: To evaluate changes in pulse pressure (PP) and markers of cardiovascular autonomic neuropathy (CAN) according to duration of type 1 diabetes mellitus (T1DM). METHODS: This cross-sectional ... [more ▼]
BACKGROUND: To evaluate changes in pulse pressure (PP) and markers of cardiovascular autonomic neuropathy (CAN) according to duration of type 1 diabetes mellitus (T1DM). METHODS: This cross-sectional controlled study evaluated 159 diabetic patients during a 3-min posture test (standing-squatting-standing) with continuous measurement of systolic (SBP), diastolic (DBP) and mean (MBP) blood pressure by a Finapres device. Arterial stiffness was indirectly assessed by PP and the slope of PP as a function of MBP calculated during the whole 3-min test. CAN was assessed by the expiration/inspiration pulse interval ratio (E/I R-R ratio) during deep breathing and by three indices measured during the squatting test. Patients were divided into four groups according to diabetes duration (<10 years, 11-20 years, 21-30 years and > 30 years from group 1 to group 4, respectively) and compared with age-matched non-diabetic subjects. RESULTS: PP progressively increased (p < 0.0001) and PP/MBP decreased (p < 0.0005) according to T1DM duration, whereas these parameters remained almost unchanged in age-matched control subjects. E/I ratio (p < 0.0001) and baroreflex gain (p < 0.0005) progressively decreased with T1DM duration. The parasympathetic index (squatting test vagal ratio-SqTv) significantly increased (p < 0.0001), whereas the sympathetic index (squatting test sympathetic ratio-SqTs) only tended to decrease (p = 0.12) according to diabetes duration. No such changes in CAN indices were observed in the non-diabetic population. CONCLUSIONS: PP increased according to T1DM duration in an age range where PP remained almost stable in controls, in agreement with accelerated arterial stiffening due to chronic hyperglycaemia. The baroreflex gain decreased and other indices of CAN also deteriorated with diabetes duration, more so indices reflecting parasympathetic rather than sympathetic dysfunction. [less ▲]Detailed reference viewed: 42 (3 ULg)
De l'analytique existentiale à la zoologie privative: le problème de la différence anthropologique et l'amorce du "tournant"
in Alter : Revue de Phénoménologie (2009), 17Detailed reference viewed: 29 (7 ULg)
Pharmacokinetics for once- versus twice-daily tacrolimus formulations in de novo kidney transplantation: a randomized, open-label trial.
; Squifflet, Jean-Paul ; et al
in American Journal of Transplantation (2009), 9(11), 2505-13
Tacrolimus, a cornerstone immunosuppressant, is widely available as a twice-daily formulation (Tacrolimus BID). A once-daily prolonged-release formulation (Tacrolimus QD) has been developed that may ... [more ▼]
Tacrolimus, a cornerstone immunosuppressant, is widely available as a twice-daily formulation (Tacrolimus BID). A once-daily prolonged-release formulation (Tacrolimus QD) has been developed that may improve adherence and impart long-lasting graft protection. This study compared the pharmacokinetics (PK) of tacrolimus in de novo kidney transplant patients treated with Tacrolimus QD or Tacrolimus BID. A 6-week, open-label, randomized comparative study was conducted in centers in Europe and Australia. Eligible patients received Tacrolimus QD or Tacrolimus BID. PK profiles were obtained following the first tacrolimus dose (day 1), and twice under steady-state conditions. As secondary objectives, efficacy and safety parameters were also evaluated. Sixty-six patients completed all PK profiles (34 Tacrolimus QD, 32 Tacrolimus BID). Mean AUC(0-24) of tacrolimus on day 1 was approximately 30% lower for Tacrolimus QD than Tacrolimus BID (232 and 361 ng.h/mL, respectively), but was comparable by day 4. There was a good correlation and a similar relationship between AUC(0-24) and C(min) for both formulations. Efficacy and safety data were also comparable over the 6-week period. Tacrolimus QD can be administered once daily in the morning on the basis of the same systemic exposure and therapeutic drug monitoring concept as Tacrolimus BID. [less ▲]Detailed reference viewed: 84 (9 ULg)
Un bouleversement de la procédure pénale en vue : la présence de l’avocat dès l’arrestation judiciaire du suspect ?
in Revue de Jurisprudence de Liège, Mons et Bruxelles (2009)Detailed reference viewed: 78 (12 ULg)
Relations entre les variations de densité minérale osseuse et l'incidence des fractures vertébrales: analyse des 3 dernières années d'un traitement de 8 ans sous ranélate de strontium.
Bruyère, Olivier ; Detilleux, Johann ; et al
in Revue du Rhumatisme (2009), 76Detailed reference viewed: 13 (1 ULg)
Limit analysis of the statistics of quasi-steady non-linear aerodynamic forces for small turbulence intensities
in Probabilistic Engineering Mechanics (2009), 24(4), 552-564
This paper focuses on the estimation of statistical characteristics of a specific quasi-steady wind loading used in buffeting analyses. In this loading, the intrinsic non-linearity of aerodynamic ... [more ▼]
This paper focuses on the estimation of statistical characteristics of a specific quasi-steady wind loading used in buffeting analyses. In this loading, the intrinsic non-linearity of aerodynamic coefficients is considered and approached by a polynomial expression of any a priori chosen degree. As rigorous developments of the statistical moments would result in impractical formulations, we suggest to consider the smallness of the turbulence intensities to construct, by means of a limit analysis, approximate expressions of the raw moments of aerodynamic forces. From these expressions, approximate cumulants and associated dimensionless characteristics, such as skewness and excess coefficients, are derived. The accuracy of the proposed analytical relations is assessed by comparison with Monte Carlo simulations, and the relevance of the sophisticated non-linear loading under consideration is compared to more traditional models. [less ▲]Detailed reference viewed: 117 (13 ULg)
Synthesis of titanium dioxide nanoparticles by reactive DC magnetron sputtering
Dreesen, Laurent ; ; et al
in Thin Solid Films (2009), 518
Nanometer-sized titanium dioxide (TiO2) particles were prepared on carbon substrates by reactive direct-current magnetron sputtering. By performing measurements with high resolution electron microscopes ... [more ▼]
Nanometer-sized titanium dioxide (TiO2) particles were prepared on carbon substrates by reactive direct-current magnetron sputtering. By performing measurements with high resolution electron microscopes, the mean nanoparticle diameter and the coverage fraction of the substrate by the nanoparticles (NPs) were measured at 19 nm and 30%, respectively. Moreover, electron diffraction analysis showed that the TiO2 NPs' crystalline structure on the carbon substrate was a mixture of anatase and rutile. Finally,we provided information on the TiO2 initial growth stage: crystalline NPs were formed after deposition of amorphous nanoparticles on the substrate and heating. [less ▲]Detailed reference viewed: 99 (11 ULg)
The Worldwide Making of the Social Economy. Innovations and Changes
Defourny, Jacques ; ; et al
Book published by Acco (2009)Detailed reference viewed: 108 (10 ULg)
Stability analysis of the evaporation of a binary liquid into an inert gas, considering solute/thermal and gravity/surface tension effects
Machrafi, Hatim ; ; et al
in Proceedings (CD) of the EUROTHERM Seminar Nr. 84 “Thermodynamics of phase changes”, Namur (Belgium), May 24-27, 2009 (2009)Detailed reference viewed: 27 (9 ULg)
Does music education facilitate the perception of prosodic prominence in a foreign language?
Rasier, Laurent ; ;
Conference (2009)Detailed reference viewed: 10 (0 ULg)