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See detailThe inside-out transobturator sling for the surgical treatment of post-radical prostatectomy urinary incontinence: Short term results of a prospective study
Waltregny, David ULg; Leruth, Julie ULg; de Leval, Jean ULg

in European Urology Supplements (2009), 4(8), 336

Introduction and Objective: To prospectively evaluate the short-term safety and efficacy of a new transobturator sling procedure for treating post-radical prostatectomy (RP) stress urinary incontinence ... [more ▼]

Introduction and Objective: To prospectively evaluate the short-term safety and efficacy of a new transobturator sling procedure for treating post-radical prostatectomy (RP) stress urinary incontinence (SUI). Methods: The sling technique uses specific instruments and a polypropylene mesh with 2 arms that are passed inside to outside through the obturator foramens, pulled for compressing the bulbar urethra upward, and tied to each other across the midline. Inclusion criteria were clinically and urodynamically demonstrated SUI, positive bulbar compression test, and signed informed consent. Patients with detrusor overactivity were excluded. Baseline and followup evaluations included uroflowmetry, and continence and quality of life (QoL) questionnaires. Cure was defined by no pad use and improvement by a number of pads/d ≤ 2 and reduced by at least 50%. Complications were recorded. Results: From 04/2006 through 10/2008, 70 consecutive patients who fulfilled inclusion and exclusion criteria underwent the sling procedure using the same operative protocol. As of October 2008, 55 and 35 patients who consecutively underwent the sling procedure were expected to have a minimum followup of 6 months and 1 year, respectively. Preoperatively, 13 (24%), 25 (45%), and 17 (31%) patients were using 2, 3 to 5, and >5 pads/d, respectively. Nine and 6 patients had undergone prior surgery for SUI and/or previous pelvic irradiation, respectively. The sling procedure was preceded by an endoscopic urethrotomy in 5 (9%) patients. No perioperative complication was noted. Seven (13%) patients required suprapubic catheterization; normal voiding resumed in all 7 patients except 1 who underwent urinary diversion for radiation-induced complete anastomotic stricture. Six-month and 1-year minimum followup was available on 51 (93%) and 33 (94%) patients, respectively (Table 1). Of note, at 6 months, among the 17 patients with preoperative severe incontinence (> 5 pads/day), 9 (53%) patients were cured and 6 others (35%) were improved (1 pad/d). Overall, QoL was significantly enhanced and 85% patients were moderately to completely satisfied with the procedure. Preoperative and postoperative max flow rate and postvoid residual values were not statistically different. No sling infection, urethra erosion, persistent pain or neurological complication was observed. No sling was withdrawn or cut. Conclusions: The inside-out transobturator sling procedure appears to be safe and efficient at short term. [less ▲]

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See detailSkizze einer theoretischen Emotion
Cormann, Grégory ULg

in von Wroblewsky, Vincent (Ed.) Lebendiger Sartre (2009)

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See detailA prospective randomized multicenter trial of darbepoetin-alfa and I.V. iron administration after autologous hematopoietic stem cell transplantation.
Beguin, Yves ULg; Maertens, J.; DE PRIJCK, Bernard ULg et al

Poster (2009)

We conducted a multicenter prospective randomized study analyzing the impact of darbepoetin alfa (DA) with or mithout i.v. iron on erythroid recovery after autologous HCT.

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See detailHigh-throughput methodology applied to screening of carbohydrate-based surfactant interfacial properties for colloidal system formulations
Razafindralambo, Hary ULg; Blecker, Christophe ULg; Deroanne et al

Poster (2009)

Carbohydrate-based surfactants (CBS) constitute an attractive class of amphiphilic molecules owing to their structural diversity generating a wide range of properties which could be developed in food and ... [more ▼]

Carbohydrate-based surfactants (CBS) constitute an attractive class of amphiphilic molecules owing to their structural diversity generating a wide range of properties which could be developed in food and non-food applications. Based on many functional groups of the carbohydrate part, it is possible to design multiple amphiphilic structures of CBS varying in the hydrophilic head groups (mono-, oligo-, or polysaccharides), hydrophobic tail (mono-, di-, tricatenar) but also in the linker/spacer between them. The main structures of CBS include mono- and bicatenar glycolipids, bolaforms, and gemini. Moreover, CBS compounds can be produced from the most abundant renewable materials allowing large product concept possibilities. Among general properties of surfactants, interfacial properties molecules occupy a fundamental key role for colloidal system formulations since they control most of technological aptitudes required for forming and stabilizing food, cosmetic, agrochemical, detergent, and pharmaceutical products. High-throughput methodology applied to screening of CBS interfacial properties appears crucial for achieving optimum formulations of colloidal systems like foams and emulsions for which small amounts of single or mix surface-active agents are often needed and numerous physical and chemical parameters are involved. This general approach may be applied to any amphiphilic molecules produced from other renewable resources of surface-active compounds like micro-organisms and by direct extraction from vegetable materials. One of the key factors for the development of this methodology is the use of automated instrument systems in laboratory scale which are still lacking in this field compared to those existing in the analytical chemistry and biochemistry areas. [less ▲]

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See detailDetermination of sex and scrapie resistance genotype in preimplantation ovine embryos.
Guignot, F.; Baril, Gerard; Dupont, Francis et al

in Molecular Reproduction and Development (2009), 76(2), 183-190

The aim of this study was to test the accuracy of genotype diagnosis after pre-amplification of DNA extracted from biopsies obtained by microblade cutting of ovine embryos and to evaluate the viability of ... [more ▼]

The aim of this study was to test the accuracy of genotype diagnosis after pre-amplification of DNA extracted from biopsies obtained by microblade cutting of ovine embryos and to evaluate the viability of biopsied embryos after vitrification/warming and transfer to recipients. Sex and PrP genotypes were determined. Sex diagnosis was done by PCR amplification of ZFX/ZFY and SRY sequences after PEP-PCR while PrP genotype determination was performed after specific pre-amplification of specific target including codons 136, 154 and 171. Embryos were collected at Day 7 after oestrus. Blastocysts and expanded blastocysts were biopsied immediately after collection whereas compacted morulae were biopsied after 24 hr of in vitro culture. Eighty-nine biopsied embryos were frozen by vitrification. Fresh and vitrified whole embryos were kept as control. DNA of biopsies was extracted and pre-amplified. Sex diagnosis was efficient for 96.6% of biopsies and PrP genotyping was determined in 95.8% of codons. After embryo transfer, no significant difference was observed in lambing rate between biopsied, vitrified control and fresh embryos (54.5%, 60% and 66.6%, respectively). Embryo survival rate was not different between biopsied and whole vitrified embryos (P = 0.38). At birth, 96.7% of diagnosed sex and 95.4% of predetermined codons were correct. Lamb PrP profiles were in agreement with parental genotype. PEP-PCR coupled with sex diagnosis and nested PCR coupled with PrP genotype predetermination are very accurate techniques to genotype ovine embryo before transfer. These original results allow planning of selection of resistant genotype to scrapie and sex of offspring before transfer of cryopreserved embryo [less ▲]

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See detailPredictors of short-term outcome in brain-injured patients with disorders of consciousness.
Whyte, J.; Gosseries, Olivia ULg; Chervoneva, I. et al

in Progress in Brain Research (2009), 177

OBJECTIVES: To investigate predictors of recovery from the vegetative state (VS) and minimally conscious state (MCS) after brain injury as measured by the widely used Disability Rating Scale (DRS) and to ... [more ▼]

OBJECTIVES: To investigate predictors of recovery from the vegetative state (VS) and minimally conscious state (MCS) after brain injury as measured by the widely used Disability Rating Scale (DRS) and to explore differences in rate of recovery and predictors of recovery during inpatient rehabilitation in patients with non-traumatic (NTBI) and traumatic brain injury (TBI). DESIGN: Longitudinal observational cohort design and retrospective comparison study, in which an initial DRS score was collected at the time of study enrollment. Weekly DRS scores were recorded until discharge from the rehabilitation center for both NTBI and TBI patients. SETTING: Seven acute inpatient rehabilitation facilities in the United States and Europe with specialized programs for VS and MCS patients (the Consciousness Consortium). PARTICIPANTS: One hundred sixty-nine patients with a non-traumatic (N=50) and a traumatic (N=119) brain injury who were in the VS or MCS states. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: DRS score at 13 weeks after injury; change in DRS score over 6 weeks post-admission; and time until commands were first followed (for patients who did not show command-following at or within 2 weeks of admission). RESULTS: Both time between injury and enrollment and DRS score at enrollment were significant predictors of DRS score at week 13 post-injury but the main effect of etiology only approached significance. Etiology was however a significant predictor of the amount of recovery observed over the 6 weeks following enrollment. Time between injury and enrollment was also a good predictor of this outcome, but not DRS score at enrollment. For the time until commands were first followed, patients with better DRS scores at enrollment, and those with faster early rates of change recovered command following sooner than those with worse DRS scores or slower initial rates of change. The etiology was not a significant predictor for this last outcome. None of these predictive models explained sufficient variance to allow their use in individual clinical decision making. CONCLUSIONS: Time post-injury and DRS score at enrollment are predictors of early recovery among patients with disorders of consciousness, depending on the outcome measure chosen. Etiology was also a significant predictor in some analyses, with traumatically injured patients recovering more than those with non-traumatic injuries. However, the hypothesized interaction between etiology and time post-injury did not reach significance in any of the analyses suggesting that, within the time frame studied, the decline in prognosis with the passage of time was similar in the two groups. [less ▲]

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See detailVerslag van de workshop "Compétences terminales / Eindtermen ASO"
Rasier, Laurent ULg; De Valck, Inez

in Hiligsmann, Philippe (Ed.) Met Nederlands aan de slag / Au travail, en néerlandais (2009)

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See detailMapping QTL influencing gastrointestinal nematode burden in Dutch Holstein-Friesian dairy cattle.
Coppieters, Wouter ULg; Mes, Ted H M; Druet, Tom ULg et al

in BMC Genomics (2009), 10

BACKGROUND: Parasitic gastroenteritis caused by nematodes is only second to mastitis in terms of health costs to dairy farmers in developed countries. Sustainable control strategies complementing ... [more ▼]

BACKGROUND: Parasitic gastroenteritis caused by nematodes is only second to mastitis in terms of health costs to dairy farmers in developed countries. Sustainable control strategies complementing anthelmintics are desired, including selective breeding for enhanced resistance. RESULTS AND CONCLUSION: To quantify and characterize the genetic contribution to variation in resistance to gastro-intestinal parasites, we measured the heritability of faecal egg and larval counts in the Dutch Holstein-Friesian dairy cattle population. The heritability of faecal egg counts ranged from 7 to 21% and was generally higher than for larval counts. We performed a whole genome scan in 12 paternal half-daughter groups for a total of 768 cows, corresponding to the approximately 10% most and least infected daughters within each family (selective genotyping). Two genome-wide significant QTL were identified in an across-family analysis, respectively on chromosomes 9 and 19, coinciding with previous findings in orthologous chromosomal regions in sheep. We identified six more suggestive QTL by within-family analysis. An additional 73 informative SNPs were genotyped on chromosome 19 and the ensuing high density map used in a variance component approach to simultaneously exploit linkage and linkage disequilibrium in an initial inconclusive attempt to refine the QTL map position. [less ▲]

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See detailMagnetically controlled superconducting weak links
Van de Vondel, J.; Silhanek, Alejandro ULg; Raes, B. et al

in Applied Physics Letters (2009), 95(3),

We have designed and characterized a magnetic template which can be switched between chains of parallel and antiparallel field distribution by applying an in-plane magnetic field. The parallel field ... [more ▼]

We have designed and characterized a magnetic template which can be switched between chains of parallel and antiparallel field distribution by applying an in-plane magnetic field. The parallel field profile creates highly mobile vortex channels in a superconducting film deposited on top, reproducing the behavior of a weak link as evidenced by the presence of Shapiro steps in the current-voltage characteristics under rf excitation. The Josephson coupling can be fully suppressed by changing the field distribution to the antiparallel state. As a result, a reversible ON/OFF switch for magnetically induced weak links has been demonstrated. [less ▲]

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See detailSelf-organized mode-locking effect in superconductor/ferromagnet hybrids
Van de Vondel, J.; Silhanek, Alejandro ULg; Metlushko, V. et al

in Physical Review. B : Condensed Matter (2009), 79(5),

The vortex dynamics in a low-temperature superconductor deposited on top of a rectangular array of micrometer size permalloy triangles is investigated experimentally. The rectangular unit cell is such ... [more ▼]

The vortex dynamics in a low-temperature superconductor deposited on top of a rectangular array of micrometer size permalloy triangles is investigated experimentally. The rectangular unit cell is such that neighboring triangles physically touch each other along one direction. This design stabilizes remanent states which differ from the magnetic vortex state typical of individual noninteracting triangles. Magnetic force microscopy images have revealed that the magnetic landscape of the template can be switched to an ordered configuration after magnetizing the sample with an in-plane field. The ordered phase exhibits a broad flux-flow regime with relatively low critical current and a highly anisotropic response. This behavior is caused by the spontaneous formation of two separated rows of vortices and antivortices along each line of connected triangles. The existence of a clear flux-flow regime at zero external field supports this interpretation. The density of induced vortex-antivortex pairs is directly obtained using a high-frequency measurement technique which allows us to resolve the discrete motion of vortices. Strikingly, the presence of vortex-antivortex rows gives rise to a self-organized synchronized motion of vortices which manifests itself as field independent Shapiro steps in the current-voltage characteristics. [less ▲]

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See detailLes principales techniques de neuroimagerie fonctionnelle et leur utilité pour l’étude du substrat neuronal du développement cognitif typique et atypique
Majerus, Steve ULg; Metz-Lutz, Marie-Noelle

in Poncelet, Martine; Majerus, Steve; Van der Linden, Martial (Eds.) Traité de Neuropsychologie de l'Enfant (2009)

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See detailDemixing processes in AgPd superlattices
Dumont, Jacques; Verstraete, Matthieu ULg; Wiame, Francis et al

in Journal of Physics : Condensed Matter (2009), 21

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See detailBibliographie
Robert, Laurent ULg; Parent, Sabrina; Purnelle, Gérald ULg

in Demoulin, Laurent; Purnelle, Gérald (Eds.) Textyles n°35: François Jacqmin (2009)

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See detailCarte hydrogéologique de Wallonie, 1/25000. 64/3-4 Libin-Bras, notice explicative.
Bouezmarni, Mohamed ULg; Denne, Pierre; Debbaut, Vincent ULg

Book published by SPW, DGARNE - peer reviewed (2009)

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See detailLes troubles spécifiques du développement du langage.
Majerus, Steve ULg; Zesiger, Pascal

in Poncelet, Martine; Majerus, Steve; Van der Linden, Martial (Eds.) Traité de Neuropsychologie de l'Enfant (2009)

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See detailStructural, Magnetic and Mössbauer Spectral Study of the Electronic Spin-state Transition in {Fe[HC(3-Mepz)2(5-Mepz)]2}(BF4)2
Reger, Daniel; Elgin, J.; Foley, E. et al

in Inorganic Chemistry (2009), 48

The complex {Fe[HC(3-Mepz)2(5-Mepz)]2}(BF4)2 (pz = pyrazolyl ring) has been prepared by the reaction of HC(3-Mepz)2(5-Mepz) with Fe(BF4)2·6H2O. The solid state structures obtained at 294 and 150 K show a ... [more ▼]

The complex {Fe[HC(3-Mepz)2(5-Mepz)]2}(BF4)2 (pz = pyrazolyl ring) has been prepared by the reaction of HC(3-Mepz)2(5-Mepz) with Fe(BF4)2·6H2O. The solid state structures obtained at 294 and 150 K show a distorted iron(II) octahedral N6 coordination environment with the largest deviations arising from the restrictions imposed by the chelate rings. At 294 K the complex is predominately high-spin with Fe–N bond distances averaging 2.14 Å, distances that are somewhat shorter than expected for a purely high-spin iron(II) complex because of the presence of an admixture of ca. 70 (I get 80 from both mag and X-ray, 3/15, where 3 is the subtraction of 2.14 and 2.17 and 15 1.99 and 2.14 and from Figure 3b) percent high-spin and 30 (20) percent low-spin iron(II). At 294 K the twisting of the pyrazolyl rings from the ideal C3v symmetry averages only 2.2o, a much smaller twist than has been observed previously in similar complexes. At 150 K the Fe–N bond distances average 1.99 Å, indicative of an almost fully low-spin iron(II) complex; the twist angle is only 1.3o, as expected for a complex with these Fe–N bond distances. The magnetic properties show that the complex undergoes a gradual change from low-spin iron(II) below 85 K to high-spin iron(II) at 400 K. The 4.2 to 60 K Mössbauer spectra correspond to a fully low-spin iron(II) complex but, upon further warming, the iron(II) begins to undergo spin-state relaxation on the Mössbauer time scale such that, at 155 and 315 K, the complex is 7.5 and 65 percent high-spin in the absence of any adjustment for the differing low-spin and high-spin recoil-free fractions. I would replace the previous sentence with the red. I see no reason to give the % from the Mössbauer in the abstract as it is likely a bit low as discussed in detail – neither the mag data nor X-ray data have the recoil issue. The last sentence in the abstract is the key information. OK The 4.2 to 60 K Mössbauer spectra correspond to a fully low-spin-iron(II) complex but, upon further warming above 85 K the iron(II) begins to undergo spin-state relaxation between the low- and high-spin forms on the Mössbauer time scale. At 155 and 315 K the complex exhibits spin-state relaxation rates of 0.36 and 7.38 MHz, respectively, and an Arrhenius plot of the logarithm of the relaxation rate yields an activation energy of 670 ± 40 cm–1 for the spin-state relaxation. [less ▲]

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See detailApproche neuropsychologique du syndrome de Williams : Introduction générale et aspects langagiers.
Majerus, Steve ULg; Poncelet, Martine ULg; Barisnikov, Koviljka et al

in Poncelet, Martine; Majerus, Steve; Van der Linden, Martial (Eds.) Traité de Neuropsychologie de l'Enfant (2009)

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See detailEntraînement excentrique des rotateurs d'épaule
Forthomme, Bénédicte ULg; Chague, Lucie ULg; Crielaard, Jean-Michel ULg et al

in Croisier, Jean-Louis; Codine, Philippe (Eds.) Exercice musculaire excentrique (2009)

In this study, we have investigated the influence of the installation on the dynamometer and of the mode of contraction used during a rotator cuff muscle training. 24 subjects were divided into 3 groups ... [more ▼]

In this study, we have investigated the influence of the installation on the dynamometer and of the mode of contraction used during a rotator cuff muscle training. 24 subjects were divided into 3 groups. Two groups of 8 subjects performed a training of the Internal Rotators (IR) in concentric mode (60°/s and 240°/s) and of the External Rotators in eccentric mode (60°/s). The first group was trained at 45° of abduction; the second was trained at 90° of abduction. The third group did not perform any shoulder training. All patients were assessed thanks to the isokinetic device ((3) x 60°/s concentric – (5) x 240°/s concentric – (4) x 60°/s eccentric) before and after training. Only the group trained at 45° of abduction increased the isokinetic maximal peak torque (+ p) in concentric mode during the second isokinetic assessment. No subject showed improvement through the eccentric exercise. They also improved the throw of the ball (+ 8.5 %). Possible feeling of discomfort and signs of subacromial conflict explained that no progression was recorded after training at 90° of abduction. Likewise, the eccentric mode would major the inhibition limiting the strength increase. Even if 90° of abduction seems more specific for assessment, 45° of abduction is more suitable for training. [less ▲]

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See detailConcept d'équilibre agonistes / antagonistes de l'épaule
Forthomme, Bénédicte ULg; Crielaard, Jean-Michel ULg; Croisier, Jean-Louis ULg

in Croisier, Jean-Louis; Codine, Philippe (Eds.) Exercice musculaire excentrique (2009)

Besides the concentric classical ratios, the eccentric isokinetic assessment of the muscle shoulder allows us to build some specific ratios. The mixed ratio combines the eccentric maximal contraction of ... [more ▼]

Besides the concentric classical ratios, the eccentric isokinetic assessment of the muscle shoulder allows us to build some specific ratios. The mixed ratio combines the eccentric maximal contraction of the external rotators (ER) and the concentric maximal strength of the internal rotators (IR). The mixed ratio is frequently decreased among overhead athletes. This imbalance could rise to shoulder tendinopathy, but seemed to be linked with field performance. The functional ratio corresponds to the balance between the ER in concentric mode and the IR in eccentric contraction. The unstable shoulder shows a trend to lower functional ratios, highlighting the weakness of the eccentric IR in that pathology. [less ▲]

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