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See detailStructure of the archaeal pab87 peptidase reveals a novel self-compartmentalizing protease family.
Delfosse, Vanessa; Girard, Eric; Birck, Catherine et al

in PLoS ONE (2009), 4(3), 4712

Self-compartmentalizing proteases orchestrate protein turnover through an original architecture characterized by a central catalytic chamber. Here we report the first structure of an archaeal member of a ... [more ▼]

Self-compartmentalizing proteases orchestrate protein turnover through an original architecture characterized by a central catalytic chamber. Here we report the first structure of an archaeal member of a new self-compartmentalizing protease family forming a cubic-shaped octamer with D(4) symmetry and referred to as CubicO. We solved the structure of the Pyrococcus abyssi Pab87 protein at 2.2 A resolution using the anomalous signal of the high-phasing-power lanthanide derivative Lu-HPDO3A. A 20 A wide channel runs through this supramolecular assembly of 0.4 MDa, giving access to a 60 A wide central chamber holding the eight active sites. Surprisingly, activity assays revealed that Pab87 degrades specifically d-amino acid containing peptides, which have never been observed in archaea. Genomic context of the Pab87 gene showed that it is surrounded by genes involved in the amino acid/peptide transport or metabolism. We propose that CubicO proteases are involved in the processing of d-peptides from environmental origins. [less ▲]

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See detailSub-Rayleigh quantum imaging using single-photon sources
Thiel, C.; Bastin, Thierry ULg; von Zanthier, J. et al

in Physical Review. A (2009), 80

We propose a technique capable of imaging a distinct physical object with sub-Rayleigh resolution in an ordinary far-field imaging setup using single-photon sources and linear optical tools only. We ... [more ▼]

We propose a technique capable of imaging a distinct physical object with sub-Rayleigh resolution in an ordinary far-field imaging setup using single-photon sources and linear optical tools only. We exemplify our method for the case of a rectangular aperture and two or four single-photon emitters obtaining a resolution enhanced by a factor of 2 or 4, respectively. [less ▲]

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See detailEANA European Astrobiology workhop, Program and abstracts
Javaux, Emmanuelle ULg; Dehant, Véronique; Muller, Christian

Book (2009)

EANA Euroepan Astrobiology workhop, Program and abstracts, Brussels 12-14 oct 2009

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See detailBiomagnification of naturally-produced methoxylated polybrominated diphenyl ethers (MeO-PBDEs) in harbour seals and harbour porpoises from the Southern North Sea
Weijs, Liesbeth; Losada, Sara; Das, Krishna ULg et al

in Environment International (2009), 35

Harbour seals and harbour porpoises are top predator species from the North Sea, have long life spans and hence, are known to accumulate high levels of anthropogenic contaminants. To gain knowledge about ... [more ▼]

Harbour seals and harbour porpoises are top predator species from the North Sea, have long life spans and hence, are known to accumulate high levels of anthropogenic contaminants. To gain knowledge about the behaviour of naturally-produced compounds in these marine mammals, the biomagnification of naturally-produced methoxylated polybrominated diphenyl ethers (MeO-PBDEs) was assessed. The biomagnification of MeO-PBDEs (2'-MeO-BDE 68 and 6-MeO-BDE 47) was lower in harbour seals (all biomagnification factors (BMFs) < 1) compared to the same age-gender groups of the harbour porpoises (all BMFs > 1). This may indicate a better metabolic breakdown of MeO-PBDEs in harbour seals, as was previously suggested for polybrominated diphenyl ethers (PBDEs). In both predators, 6-MeO-BDE 47 had the highest concentrations (range: 45-483 ng/g lw and 2-38 ng/g lw for harbour porpoises and seals, respectively) compared to 2'-MeO-BDE 68 (range: 2-28 ng/g lw and 1-6 ng/g lw for harbour porpoises and seals, respectively). In general, the highest concentrations were found in juveniles, suggesting an increased biotransformation capacity with age or the influence of dilution by growth for both species. Here we show that naturally-produced brominated organic compounds can biomagnify and accumulate in North Sea top predators, although to a lesser extent than anthropogenic lipophilic contaminants, such as polychlorinated biphenyls (PCBs) or PBDEs. [less ▲]

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See detailLong-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial.
Kahan, Andre; Uebelhart, Daniel; De Vathaire, Florent et al

in Arthritis and Rheumatism (2009), 60(2), 524-33

OBJECTIVE: To assess the long-term effects of chondroitins 4 and 6 sulfate (CS) on the radiographic progression of, and symptom changes associated with, knee osteoarthritis (OA). METHODS: We performed an ... [more ▼]

OBJECTIVE: To assess the long-term effects of chondroitins 4 and 6 sulfate (CS) on the radiographic progression of, and symptom changes associated with, knee osteoarthritis (OA). METHODS: We performed an international, randomized, double-blind, placebo-controlled trial in which 622 patients with knee OA were randomly assigned to receive either 800 mg CS (n = 309 patients) or placebo (n = 313 patients) once daily for 2 years. Radiographs of the target knee, using the Lyon schuss view, were obtained at the time of enrollment and at 12, 18, and 24 months. The minimum joint space width (JSW) of the medial compartment of the tibiofemoral joint was assessed by digital image analysis. The primary outcome was the loss in minimum JSW over 2 years. RESULTS: The intent-to-treat analysis demonstrated a significant reduction (P < 0.0001) in minimum JSW loss in the CS group (mean +/- SEM -0.07 +/- 0.03 mm) as compared with the placebo group (-0.31 +/- 0.04 mm). The percentage of patients with radiographic progression > or =0.25 mm was significantly reduced in the CS group compared with the placebo group (28% versus 41% [P < 0.0005]; relative risk reduction 33% [95% confidence interval 16-46%]). The number of patients needed to treat was 8 (95% confidence interval 5-17). Pain improved significantly faster in the CS group than in the placebo group (P < 0.01). There were no differences in safety between groups. CONCLUSION: The long-term combined structure-modifying and symptom-modifying effects of CS suggest that it could be a disease-modifying agent in patients with knee OA. [less ▲]

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See detailLe droit administratif: droit dans le mur ?
Durviaux, Ann-Lawrence ULg

in Les murs (2009)

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See detailLe jeu de l'acteur: une nouvelle méthode pour aborder l'affirmation de soi. Résultats d'une première étude portant sur trois groupes et follow-up
Delvaux, Muriel ULg; Sarto, Danielle; Roodthooft, S. et al

in Revue Francophone de Clinique Comportementale et Cognitive (2009)

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See detailOn the use of posture verbs by French-speaking learners of Dutch : a corpus-based study.
Lemmens, Maarten; Perrez, Julien ULg

Conference (2009)

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See detailATRP of Methacrylates Catalysed by Homo- and Heterobimetallic Ruthenium Complexes
Borguet, Yannick ULg; Sauvage, Xavier; Bicchielli, Dario ULg et al

in Matyjaszewski, Krzysztof (Ed.) Controlled/Living Radical Polymerization: Progress in ATRP (2009)

The catalytic activity of a series of ruthenium-based homo- and heterobimetallic complexes was determined by investigating the atom transfer radical polymerisation of methyl methacrylate. The complexes ... [more ▼]

The catalytic activity of a series of ruthenium-based homo- and heterobimetallic complexes was determined by investigating the atom transfer radical polymerisation of methyl methacrylate. The complexes under investigation were [(arene)Ru(µ-Cl)3RuCl(C2H4)-(L)] (L = PCy3 or a N-heterocyclic carbene ligand), [(p-cymene)-Ru(µ-Cl)3RuCl(=C=CHR)(PCy3)] (R = Ph or t-Bu), and [RuCl2-(p-cymene){PCy2(CH2)2(eta5-C5H4)TiX2(eta5-C5H5)}] (X = Cl, F, and OBz). The catalytic activity of a variety of related [(p-cymene)-ClRu(µ-Cl)2Ru(O‚^N)(=CHPh)] complexes (O^N is a Schiff base ligand) is also reported. The results clearly demonstrate that the ligands strongly affect the ability of the resulting ruthenium complexes to favour the occurrence of a well-behaved ATRP. [less ▲]

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See detailPréface de : La dévalaison des poissons dans la Meuse moyenne belge
Philippart, Jean-Claude ULg; Poncin, Pascal ULg

in Sonny, Damien (Ed.) La dévalaison des poissons dans la Meuse moyenne belge (2009)

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See detailSubjective evaluation of the long-term efficacy of speech therapy on dysfunctional dysphonia.
Morsomme, Dominique ULg; Faurichon de la Bardonnie, Marie; Verduyckt, Ingrid et al

in Journal of Voice (2009)

The objective of the study was to measure the subjective long-term effects of vocal therapy (more than 6 months) in 29 patients suffering from dysfunctional dysphonia. Four subjective measurements were ... [more ▼]

The objective of the study was to measure the subjective long-term effects of vocal therapy (more than 6 months) in 29 patients suffering from dysfunctional dysphonia. Four subjective measurements were used: one visual analog scale ranging from 0 (not efficient at all) to 100 (very efficient); one question "Is the speech therapy still efficient?," answered by yes or no; the GRB parameters of the GRBAS scale (evaluated by the patient); and the VHI-10. The results show that 76% of the patients consider that the vocal therapy they received is still efficient. On the vocal quality (G), roughness (R), and breathiness (B) parameters, we observe a high degree of satisfaction on the G parameter (median=77). The scores on the R and B parameters are lower (median R=12, S=5). Roughness is significantly correlated to the Grade (Spearman coefficient r=0.516, P=0.004), whereas breathiness is not (P=0.251, NS). The comparison of the results on the VHI-10 pre and post treatment shows a significant decrease in the grade of perceived handicap (medians 15 vs 11, P=0.017). The correlations between the judgment of the treatment's efficacy and the vocal quality is significant (r=0.623, P<0.001) as well as the correlation between the VHI-10 and the length of the treatment (r=0.416, P=0.035). The conclusion can be made that speech therapy plays an important role in long-term treatment of dysfunctional dysphonias. [less ▲]

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See detailStructural, Magnetic and Mössbauer Spectral Study of the Electronic Spin-state Transition in {Fe[HC(3-Mepz)2(5-Mepz)]2}(BF4)2
Reger, Daniel; Elgin, J.; Foley, E. et al

in Inorganic Chemistry (2009), 48

The complex {Fe[HC(3-Mepz)2(5-Mepz)]2}(BF4)2 (pz = pyrazolyl ring) has been prepared by the reaction of HC(3-Mepz)2(5-Mepz) with Fe(BF4)2·6H2O. The solid state structures obtained at 294 and 150 K show a ... [more ▼]

The complex {Fe[HC(3-Mepz)2(5-Mepz)]2}(BF4)2 (pz = pyrazolyl ring) has been prepared by the reaction of HC(3-Mepz)2(5-Mepz) with Fe(BF4)2·6H2O. The solid state structures obtained at 294 and 150 K show a distorted iron(II) octahedral N6 coordination environment with the largest deviations arising from the restrictions imposed by the chelate rings. At 294 K the complex is predominately high-spin with Fe–N bond distances averaging 2.14 Å, distances that are somewhat shorter than expected for a purely high-spin iron(II) complex because of the presence of an admixture of ca. 70 (I get 80 from both mag and X-ray, 3/15, where 3 is the subtraction of 2.14 and 2.17 and 15 1.99 and 2.14 and from Figure 3b) percent high-spin and 30 (20) percent low-spin iron(II). At 294 K the twisting of the pyrazolyl rings from the ideal C3v symmetry averages only 2.2o, a much smaller twist than has been observed previously in similar complexes. At 150 K the Fe–N bond distances average 1.99 Å, indicative of an almost fully low-spin iron(II) complex; the twist angle is only 1.3o, as expected for a complex with these Fe–N bond distances. The magnetic properties show that the complex undergoes a gradual change from low-spin iron(II) below 85 K to high-spin iron(II) at 400 K. The 4.2 to 60 K Mössbauer spectra correspond to a fully low-spin iron(II) complex but, upon further warming, the iron(II) begins to undergo spin-state relaxation on the Mössbauer time scale such that, at 155 and 315 K, the complex is 7.5 and 65 percent high-spin in the absence of any adjustment for the differing low-spin and high-spin recoil-free fractions. I would replace the previous sentence with the red. I see no reason to give the % from the Mössbauer in the abstract as it is likely a bit low as discussed in detail – neither the mag data nor X-ray data have the recoil issue. The last sentence in the abstract is the key information. OK The 4.2 to 60 K Mössbauer spectra correspond to a fully low-spin-iron(II) complex but, upon further warming above 85 K the iron(II) begins to undergo spin-state relaxation between the low- and high-spin forms on the Mössbauer time scale. At 155 and 315 K the complex exhibits spin-state relaxation rates of 0.36 and 7.38 MHz, respectively, and an Arrhenius plot of the logarithm of the relaxation rate yields an activation energy of 670 ± 40 cm–1 for the spin-state relaxation. [less ▲]

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See detailMagnetic model refinement via a perturbation finite element method – from 1D to 3D
Dular, Patrick ULg; V Sabariego, Ruth ULg; Krähenbühl, Laurent

in COMPEL (2009), 28(4), 974-988

Purpose – The purpose of this paper is to develop a sub-domain perturbation technique for refining magnetic circuit models with finite element (FE) models of different dimensions. Design/methodology ... [more ▼]

Purpose – The purpose of this paper is to develop a sub-domain perturbation technique for refining magnetic circuit models with finite element (FE) models of different dimensions. Design/methodology/approach – A simplified problem considering ideal flux tubes is first solved, as either a 1D magnetic circuit or a simplified FE problem. Its solution is then corrected via FE perturbation problems considering the actual flux tube geometry and the exterior regions, that allow first 2D and then 3D leakage fluxes. Each of these sub-problems requires an appropriate proper volume mesh, with no need of interconnection. The solutions are transferred from one problem to the other through projections of source fields between meshes. Findings – The developed perturbation FE method allows to split magnetic circuit analyses into subproblems of lower complexity with regard to meshing operations and computational aspects. A natural progression from simple to more elaborate models, from 1D to 3D geometries, is thus possible, while quantifying the gain given by each model refinement and justifying its utility. Originality/value – Approximate problems with ideal flux tubes are accurately corrected when accounting for leakage fluxes via surface sources of perturbations. The constraints involved in the subproblems are carefully defined in the resulting FE formulations, respecting their inherent strong and weak nature. As a result, an efficient and accurate computation of local fields and global quantities, i.e. flux, MMF, reluctance, is obtained. The method is naturally adapted to parameterized analyses on geometrical and material data. [less ▲]

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See detailDevelopment of a strategy to study toxicodynamic of pollutants in spawning sea turtles
Dyc, Christelle ULg; Bouquegneau, Jean-Marie ULg; De Pauw-Gillet, Marie-Claire ULg et al

in Proceedings of the 29th Annual Symposium on Sea Turtle Biology and Conservation (2009)

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See detailPortal on institutional territorial indicators available on internet in Europe
Devillet, Guénaël ULg; Breuer, Christophe ULg; Ostir, K. et al

in territorial-intellingence.eu (2009)

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See detailMuzeologija : Istorija, razvoj i savremeni izazovi
Gob, André ULg; Drouguet, Noémie ULg

Book published by Clio - Prevela s francuskog (trad.) Vesna Injac (2009)

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See detailFrançois Jacqmin, auteur comique
Robert, Laurent ULg

in Textyles : Revue des Lettres Belges de Langue Française (2009), 35

Cet article propose une analyse de la notion de comique dans l'oeuvre de François Jacqmin. Il montre que l'ironie est le degré de comique que le poète peut atteindre. C'est aussi grâce à l'ironie que le ... [more ▼]

Cet article propose une analyse de la notion de comique dans l'oeuvre de François Jacqmin. Il montre que l'ironie est le degré de comique que le poète peut atteindre. C'est aussi grâce à l'ironie que le poète exprime sa conception du langage et de la poésie. [less ▲]

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