References of "2009"
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See detailExploring the L1-L2 relationship in the L2 acquisition of prosody
Rasier, Laurent ULg; Hiligsmann, Philippe

Conference (2009)

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See detailA time-dependent multi-scale damage model for rocks based on sub-critical growth of micro-cracks
François, Bertrand ULg; Dascalu, Cristian; Operchalska, Beata

in 1st International Symposium on Computational Geomechanics (ComGeo I) (2009)

The stability of underground cavities, such as the facilities for deep repositories of nuclear wastes, must be evaluated by considering the induced damaged zone due to the excavation phase, related to ... [more ▼]

The stability of underground cavities, such as the facilities for deep repositories of nuclear wastes, must be evaluated by considering the induced damaged zone due to the excavation phase, related to nucleation and growth of micro-cracks in the rock matrix. The evolution of the rock damage is time-dependent mainly because of sub-critical propagation of cracks. This paper presents the modeling of the macroscopic mechanical behavior of quasi-brittle rocks, using a micro-mechanical approach. The model is built in two steps. First, the elastic coefficients are calculated at the micro-scale in finite periodical cells, with respect to the micro-cracks length and their orientation. Then, these effective elastic properties are used in a sub-critical damage law in order to establish the evolution of the damaged zone. This damage law is obtained as a differential equation depending on time. The macroscopic behavior is determined, at each step, by an asymptotic homogenization procedure. The developed model enables to reproduce not only the classical short term stress-strain response of quasi-brittle rocks on complex loading paths (in tension and compression) but also the long-term behavior encountering relaxation and creep effects. In this model, the size of the microscopic cell, corresponding to the distance between two adjacent micro-cracks, is a material parameter that affects the macroscopic response of the material. [less ▲]

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See detailInfluence of source and levels of dietary fiber on in vivo nitrogen excretion pathways in pigs and in vitro fermentation and protein synthesis by fecal bacteria
Bindelle, Jérôme ULg; Buldgen, André; Delacollette, Maud et al

in Journal of Animal Science (2009), 87

The inclusion of dietary fiber (DF) in diets has been suggested as a way to reduce ammonia emission in pig barns because it contributes to a shift in N excretion from urine to feces due to enhanced ... [more ▼]

The inclusion of dietary fiber (DF) in diets has been suggested as a way to reduce ammonia emission in pig barns because it contributes to a shift in N excretion from urine to feces due to enhanced bacterial growth in the intestines. This study compared an in vitro method to measure bacterial protein synthesis during fermentation to in vivo N excretion shift induced by diets differing in DF concentrations and solubility. The first experiment measured the effect of graded concentrations of sugar beet pulp (SBP; 0, 10, 20 and 30%) in corn-soybean meal-based diets on in vivo N excretion partitioning between urine and feces. A second experiment investigated the replacement of SBP, rich in soluble DF, by oat hulls (OH), rich in insoluble DF (20:0; 10.5:10.5; 0:22%, respectively). In parallel, the fermentation characteristics of the dietary carbohydrates not digested in the small intestine was evaluated in an in vitro gas test, based on their incubation with colonic microbiota, using a mineral buffer solution enriched with 15N. The N originating from the buffer solution incorporated into the bacterial proteins (BNI) was measured when half of the final gas volume was produced (T/2: 8.5 to 14.5 h of fermentation) and after 72 h of fermentation. Short-chain fatty acids (SCFA) were determined in the liquid phase. In the first experiment, the inclusion of SBP linearly decreased urinary N excretion from 0.285 to 0.215 g N excreted in urine per g N ingested and urinary-N:fecal–N excretion ratio from 2.171 to 1.177 (P < 0.01). In the second experiment, the substitution of SBP by OH linearly increased urinary-N:fecal–N excretion ratio (P = 0.009). Unlike SCFA production, BNI was greater at T/2 than at 72 h of fermentation. Sugar beet pulp enhanced BNI linearly (P < 0.001): 2.01, 2.06 and 2.35 mg g-1 diet with 10, 20 and 30% SBP, respectively, as compared to 1.51 mg for the control diet. The substitution of SBP by OH decreased BNI (P < 0.01). With the exception of final gas production, all in vitro kinetics characteristics and BNI were correlated to in vivo N excretion parameters and regression equations for the prediction of N excretion pathways from in vitro data were identified. Even if the presence of resistant starch in the diet might alter the composition of the fibrous residue that is fermented, it can be concluded that the in vitro method is a possible useful tool for the formulation of diets reducing the effects of pig production on the environment. [less ▲]

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See detailImproving the seismic robustness of reinforced concrete frames by using locally hybrid steel-concrete columns
Degée, Hervé ULg; Plumier, André ULg

in Proceedings of the STESSA 2009 Conference (2009)

The proposed concept consists in placing a steel profile with limited size inside the reinforced concrete column of the first level of the building. This profile is not considered for the design and is ... [more ▼]

The proposed concept consists in placing a steel profile with limited size inside the reinforced concrete column of the first level of the building. This profile is not considered for the design and is essen-tially assumed to act as a safety belt activated only in case of deficiencies of the concrete under earthquake action, providing thus the requested robustness and limiting the risk of soft-storey mechanisms even in the most unfavorable conditions. Theoretical, experimental and numerical investigations summarized in the pre-sent contribution are aiming at demonstrating the efficiency of the concept. [less ▲]

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See detailStructure of PBP-A from Thermosynechococcus elongatus, a Penicillin-Binding Protein Closely Related to Class A β-Lactamases
Urbach, Carole; Evrard, Christine ULg; Pudzaitis, Vaidas et al

in Journal of Molecular Biology (2009), 386

Molecular evolution has always been a subject of discussions, and researchers are interested in understanding how proteins with similar scaffolds can catalyze different reactions. In the superfamily of ... [more ▼]

Molecular evolution has always been a subject of discussions, and researchers are interested in understanding how proteins with similar scaffolds can catalyze different reactions. In the superfamily of serine penicillin-recognizing enzymes, D-alanyl-D-alanine peptidases and β-lactamases are phylogenetically linked but feature large differences of reactivity towards their respective substrates. In particular, while β-lactamases hydrolyze penicillins very fast, leading to their inactivation, these molecules inhibit D-alanyl-D-alanine peptidases by forming stable covalent penicilloyl enzymes. In cyanobacteria, we have discovered a new family of penicillin-binding proteins (PBPs) presenting all the sequence features of class A β-lactamases but having a six-amino-acid deletion in the conserved Ω-loop and lacking the essential Glu166 known to be involved in the penicillin hydrolysis mechanism. With the aim of evolving a member of this family into a β-lactamase, PBP-A from Thermosynechococcus elongatus has been chosen because of its thermostability. Based on sequence alignments, introduction of a glutamate in position 158 of the shorter Ω-loop afforded an enzyme with a 50-fold increase in the rate of penicillin hydrolysis. The crystal structures of PBP-A in the free and penicilloylated forms at 1.9 Å resolution and of L158E mutant at 1.5 Å resolution were also solved, giving insights in the catalytic mechanism of the proteins. Since all the active-site elements of PBP-A-L158E, including an essential water molecule, are almost perfectly superimposed with those of a class A β-lactamase such as TEM-1, the question why our mutant is still 5 orders of magnitude less active as a penicillinase remains and our results emphasize how far we are from understanding the secrets of enzymes. Based on the few minor differences between the active sites of PBP-A and TEM-1,mutations were introduced in the L158E enzyme, but while activities on D-Ala-D-Ala mimicking substrates were severely impaired, further improvement in penicillinase activity was unsuccessful. [less ▲]

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See detailPregnancy-associated glycoproteins as diagnostic tool in cattle reproduction
Gajewski, Zdzislaw; Pertajitis; Melo de Sousa, Noelita ULg et al

in Schweizer Archiv für Tierheilkunde (2009), 151(12), 577-582

Pregnancy-associated glycoproteins are powerful pregnancy markers in domestic cattle. These proteins are expressed in mono- and binucleate trophoblast cells from the first days of gestation until calving ... [more ▼]

Pregnancy-associated glycoproteins are powerful pregnancy markers in domestic cattle. These proteins are expressed in mono- and binucleate trophoblast cells from the first days of gestation until calving. Different molecules were identified as being expressed at various stages of pregnancy. However, up to date, their functions and activities during pregnancy were not yet established. Specific RIA tests were developed (classic and alternative RIA) and used to measure the concentration of these glycoproteins in blood during gestation and the postpartum period in cattle. In maternal blood, PAGs rise to detectable levels from the 24th-28th days after fertilization. A recent study indicated that PAGs can also be detected in milk samples. However, concentrations in milk are much lower when compared to those of plasma. [less ▲]

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See detailEntre Asclépios et Hippocrate. Etude des cultes guérisseurs et des médecins en Carie
Nissen, Cécile ULg

Book published by CIERGA (2009)

Asclépios et Hippocrate sont tous deux associés à l’art médical dans la Grèce antique. Cependant, l’un appartient au monde des dieux et l’autre est mortel. La distinction est d’importance et reflète ... [more ▼]

Asclépios et Hippocrate sont tous deux associés à l’art médical dans la Grèce antique. Cependant, l’un appartient au monde des dieux et l’autre est mortel. La distinction est d’importance et reflète adéquatement les deux conceptions de la médecine que ces noms portent en eux, l’une généralement qualifiée de « religieuse » et l’autre de « rationnelle ». Ces deux facettes de la médecine antique sont au cœur de la présente étude, qui s’attache à en redéfinir la portée et la complémentarité. Centrée sur la Carie, une région d’Asie Mineure qui a livré une documentation abondante, l’analyse aborde les cultes guérisseurs patronnés par Asclépios, mais aussi par Pluton et Coré à Acharaca, Men à Attouda ou encore Hémithéa à Castabos. Quant aux médecins, ils formaient une « école » célèbre à Cnide dès la période classique et à Laodicée du Lycos à l’époque impériale, mais certains d’entre eux pratiquaient de manière indépendante de toute « secte » établie. En embrassant d’un même regard des pratiques dont l’étude est souvent éclatée dans les recherches modernes, ce livre offre une vision nuancée des interactions qui existaient entre cultes guérisseurs et pratique médicale, rendant à la médecine antique l’unité qui était la sienne. [less ▲]

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See detailLocal-Level Monitoring in Decentralized Forest Management: Exploring the Spaces for Community Participation
Tol, Sokchea; Srey, Marona; Diepart, Jean-Christophe ULg

in Beaupre, Pauline; Taylor, Janet; Carson, Toby (Eds.) Emerging Trends, Challenges and Innovations Community Based Natural Resource Management (CBNRM) in Cambodia (2009)

This paper explores a participatory monitoring process initiated in Kampong Thom province with 3 Community Forestry (CF) sites where CF development was facilitated by Forestry Administration (FA) staff ... [more ▼]

This paper explores a participatory monitoring process initiated in Kampong Thom province with 3 Community Forestry (CF) sites where CF development was facilitated by Forestry Administration (FA) staff and externally supported by German Technical Support-Rural Development Programme (GTZ-RDP).The paper details the methodology used and the key outputs produced during the process, it highlights the four main principles of the principle, criteria, and indicator Monitoring and Evaluation (M&E) which are: (1) that forest health is maintained, (2) public well-being is improved, (3) community well-being is assured, and (4) external support is effective. The results show that in all three CF, the land integrity and the forest resource itself was improved between the baseline and follow-up surveys. Despite the positive results, many of the challenges and limitations were acknowledged including the difficulty in capturing all different points of view and opinions when there are such a large number of people involved and consulted as well as how this can lead to a slowdown within the whole process and is very expensive. The paper concludes suggesting that a local level monitoring system can help to build local capacity, improve decision-making, reduce conflict between local forest dependents and responsible authorities as well as empower local community members, especially marginalized groups. [less ▲]

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See detailAssessment of modelling uncertainties in long-term climate and sea level change projections "Aster"
Fichefet, T.; Loutre, M.-F.; Goosse, H. et al

Report (2009)

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See detailVariétés linguistiques en concorde et en conflit : wallon et français en Wallonie
Boutier, Marie-Guy ULg

in Travaux de linguistique : revue internationale de linguistique Française (2009), 59

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See detailAire and Foxp3 expression in a particular microenvironment for T-cell differentiation
Hansenne, Isabelle; Louis, Céline; Martens, Henri ULg et al

in Neuroimmunomodulation (2009), 16

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See detailOrigin and early evolution of life
Javaux, Emmanuelle ULg

Conference (2009)

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See detail"Metaboliquement obeses" sans exces de poids: un phenotype interpellant.
Beck, Emmanuel ULg; Scheen, André ULg

in Revue Médicale de Liège (2009), 64(1), 14-22

Obesity, especially abdominal obesity, is the main risk factor of metabolic syndrome. However, there are obviously non obese individuals who are metabolically abnormal and therefore exposed to an ... [more ▼]

Obesity, especially abdominal obesity, is the main risk factor of metabolic syndrome. However, there are obviously non obese individuals who are metabolically abnormal and therefore exposed to an increased risk of cardiovascular complications. Unfortunately, those persons fail to be detected because of a falsely reassuring body weight. The present paper aims at better understanding the etiopathogenesis and pathophysiology of this particular phenotype, at evaluating its potential clinical consequences and at describing the main principles of its therapeutic management. [less ▲]

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See detailLa médecine générale doit contribuer à l'amélioration continue de la qualité des soins et y intégrer la promotion de la santé
Vanmeerbeek, Marc ULg

in Presse Médicale (La) (2009)

Quality of care in general practice is mainly based on effectiveness of clinical and inter-personal care, and access to care. Assessment has to focus on structures and processes, more than on outcomes ... [more ▼]

Quality of care in general practice is mainly based on effectiveness of clinical and inter-personal care, and access to care. Assessment has to focus on structures and processes, more than on outcomes. The sets of clinical indicators used in some european countries, though good starting points are still incomplete to encompass the complexity of activity. Assessment of care quality by the public authorities must be acceptable to the doctors who are the object of this assessment; otherwise its conclusions will be rejected. Continuous quality improvement can maintain quality of care at a high level and maintain costs under control. Health has to be managed, and doctors have a collective responsibility towards their patients. The procedures of the quality cycle are applicable in general practice for the development of community-based projects of health promotion, within the network of care. The discipline can find in it a new lease of life and perhaps curb the loss of interest among young doctors. [less ▲]

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See detailRejection of pulse related artefact (PRA) from continuous electroencephalographic (EEG) time series recorded during functional magnetic resonance imaging (fMRI) using constraint independent component analysis (cICA).
Leclercq, Yves ULg; Balteau, Evelyne ULg; Dang Vu, Thien Thanh ULg et al

in NeuroImage (2009), 44(3), 679-91

Rejection of the pulse related artefact (PRA) from electroencephalographic (EEG) time series recorded simultaneously with fMRI data is difficult, particularly during NREM sleep because of the similarities ... [more ▼]

Rejection of the pulse related artefact (PRA) from electroencephalographic (EEG) time series recorded simultaneously with fMRI data is difficult, particularly during NREM sleep because of the similarities between sleep slow waves and PRA, in both temporal and frequency domains and the need to work with non-averaged data. Here we introduce an algorithm based on constrained independent component analysis (cICA) for PRA removal. This method has several advantages: (1) automatic detection of the components corresponding to the PRA; (2) stability of the solution and (3) computational treatability. Using multichannel EEG recordings obtained in a 3 T MR scanner, with and without concomitant fMRI acquisition, we provide evidence for the sensitivity and specificity of the method in rejecting PRA in various sleep and waking conditions. [less ▲]

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See detailL'omalizumab (Xolair) dans le traitement de l'asthme allergique persistant severe.
Schleich, FLorence ULg; Manise, Maïté ULg; Louis, Renaud ULg

in Revue Médicale de Liège (2009), 64(5-6), 313-7

L’asthme est une maladie chronique des voies aériennes. La plupart des asthmatiques ont une inflammation bronchique liée à un processus immunologique faisant intervenir les immunoglobulines E (IgE). En ... [more ▼]

L’asthme est une maladie chronique des voies aériennes. La plupart des asthmatiques ont une inflammation bronchique liée à un processus immunologique faisant intervenir les immunoglobulines E (IgE). En dépit des thérapeutiques existantes, les patients atteints d’asthme sévère ont une qualité de vie sérieusement altérée et présentent un risque élevé d’exacerbations graves pouvant parfois être fatales. L’omalizumab est un anticorps (Ac) monoclonal humanisé dirigé contre les IgE circulantes, interférant ainsi avec une des cascades moléculaires importantes dans la pathogénie de l’asthme. L’omalizumab a montré qu’il était capable d’améliorer la qualité de vie et de réduire la fréquence des exacerbations ainsi que le recours aux corticoïdes inhalés et systémiques. Selon les nouvelles recommandations de l’asthme du GINA 2006, cet agent biologique est indiqué dans l’asthme allergique persistant sévère. [less ▲]

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See detailExtracting a common high frequency signal from Northern Quebec black spruce tree-rings with a Bayesian hierarchical model
Boreux, Jean-Jacques ULg; Naveau, P.; Guin, O. et al

in Climate of the Past (2009), 5

One basic premise of dendroclimatology is that tree rings can be viewed as climate proxies, i.e. rings are assumed to contain some hidden information about past climate. From a statistical perspective ... [more ▼]

One basic premise of dendroclimatology is that tree rings can be viewed as climate proxies, i.e. rings are assumed to contain some hidden information about past climate. From a statistical perspective, this extraction problem can be understood as the search of a hidden variable which represents the common signal within a collection of tree-ring width series. Classical average-based techniques used in dendrochronology have been applied to estimate the mean behavior of this latent variable. Still, depending on tree species, regional factors and statistical methods, a precise quantification of uncertainties associated to the hidden variable distribution is difficult to assess. To model the error propagation throughout the extraction procedure, we propose and study a Bayesian hierarchical model that focuses on extracting an inter-annual high frequency signal. Our method is applied to black spruce (Picea mariana) tree-rings recorded in Northern Quebec and compared to a classical average-based techniques used by dendrochronologists. [less ▲]

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