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See detailEarly termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults.
Robe, Pierre ULg; Martin, Didier ULg; Nguyen-Khac, Minh-Tuan ULg et al

in BMC Cancer (2009), 9

BACKGROUND: Sulfasalazine, a NF-kappaB and x(c)-cystine/glutamate antiport inhibitor, has demonstrated a strong antitumoral potential in preclinical models of malignant gliomas. As it presents an ... [more ▼]

BACKGROUND: Sulfasalazine, a NF-kappaB and x(c)-cystine/glutamate antiport inhibitor, has demonstrated a strong antitumoral potential in preclinical models of malignant gliomas. As it presents an excellent safety profile, we initiated a phase 1/2 clinical study of this anti-inflammatory drug for the treatment of recurrent WHO grade 3 and 4 astrocytic gliomas in adults. METHODS: 10 patients with advanced recurrent anaplastic astrocytoma (n = 2) or glioblastoma (n = 8) aged 32-62 years were recruited prior to the planned interim analysis of the study. Subjects were randomly assigned to daily doses of 1.5, 3, 4.5, or 6 grams of oral sulfasalazine, and treated until clinical or radiological evidence of disease progression or the development of serious or unbearable side effects. Primary endpoints were the evaluation of toxicities according to the CTCAE v.3.0, and the observation of radiological tumor responses based on MacDonald criteria. RESULTS: No clinical response was observed. One tumor remained stable for 2 months with sulfasalazine treatment, at the lowest daily dose of the drug. The median progression-free survival was 32 days. Side effects were common, as all patients developed grade 1-3 adverse events (mean: 7.2/patient), four patients developed grade 4 toxicity. Two patients died while on treatment or shortly after its discontinuation. CONCLUSION: Although the proper influence of sulfasalazine treatment on patient outcome was difficult to ascertain in these debilitated patients with a large tumor burden (median KPS = 50), ISRCTN45828668 was terminated after its interim analysis. This study urges to exert cautiousness in future trials of Sulfasalazine for the treatment of malignant gliomas. TRIAL REGISTRATION: Current Controlled Trials ISRCTN45828668. [less ▲]

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See detailThe roles of lipopeptides in the biocontrol activity of Bacillus subtilis
Ongena, MARC ULg; Henry, Guillaume; Thonart, Philippe ULg

in Plant Pathology in the 21st Century, Recent developments in disease management (2009)

Bacillus subtilis species are well-known and extensively-used beneficial rhizobacteria for biocontrol of plant diseases. Their interest arises from their ability to generate a broad array of bioactive ... [more ▼]

Bacillus subtilis species are well-known and extensively-used beneficial rhizobacteria for biocontrol of plant diseases. Their interest arises from their ability to generate a broad array of bioactive metabolites among which three families of cyclic lipopeptides (CLPs). These CLPs display a huge diversity of structures and physico-chemical and biological properties which probably account for an important part of the biocontrol potential of the producing strains. Beside their antimicrobial properties, they are also involved in colonization and motility as well as in the systemic stimulation of immune system of the host plant. We summarize here the current knowledge of CLPs activities and focus on the recent findings in the context of biocontrol [less ▲]

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See detailA decade of improvements in quantification of gene expression and internal standard selection.
Thellin, Olivier ULg; Elmoualij, Benaïssa ULg; Heinen, Ernst ULg et al

in Biotechnology Advances (2009)

Major improvements have been made in mRNA quantification and internal standard selection over the last decade. Our aim in this paper is to present the main developments that are of interest for practical ... [more ▼]

Major improvements have been made in mRNA quantification and internal standard selection over the last decade. Our aim in this paper is to present the main developments that are of interest for practical laboratory work, contrasting the situation as it is now with the one of ten years ago, and presenting some excellent examples of what can be done today. Specifically, we will mainly discuss Real-Time RT-PCR major improvements that have been performed in the following areas: the most commonly used quantification techniques, the mathematical and software tools created to help researchers in their work on internal standard selection, the availability of detection chemistries and technical information and of commercial tools and services. In addition to mRNA quantification, we will also discuss some aspects of non-coding RNA and protein quantification. In addition to technical improvements, the development of international cooperation and the creation of technical databases are likely to represent a major tool for the future in the standardization of gene expression quantification. [less ▲]

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See detailEstimation of genetic parameters and genome scan for 15 semen characteristics traits of Holstein bulls.
Druet, Tom ULg; Fritz, S.; Sellem, E. et al

in Journal of Animal Breeding & Genetics (2009), 126(4), 269-77

A QTL detection experiment was performed in French dairy cattle to search for QTL related to male fertility. Ten families, involving a total of 515 bulls, were phenotyped for ejaculated volume and sperm ... [more ▼]

A QTL detection experiment was performed in French dairy cattle to search for QTL related to male fertility. Ten families, involving a total of 515 bulls, were phenotyped for ejaculated volume and sperm concentration, number of spermatozoa, motility, velocity, percentage of motile spermatozoa after thawing and abnormal spermatozoa. A set of 148 microsatellite markers were used to realize a genome scan. First, genetic parameters were estimated for all traits. Semen production traits were found to have moderate heritabilities (from 0.15 to 0.30) while some of the semen quality traits such as motility had high heritabilities (close to 0.60). Genetic correlations among traits showed negative relationships between volume and concentration and between volume and most quality traits such as motility or abnormal sperm while correlations between concentration and these traits were rather favourable. Percentages of abnormal sperm were negatively related to quality traits, especially with motility and velocity of spermatozoa. Three QTL related to abnormal sperm frequencies were significant at p < 0.01. In total, 11 QTL (p < 0.05) were detected. However, the number of QTL detected was within the range of expected false positives. Because of the lack of power to find QTL in this design further analyses are required to confirm these QTL. [less ▲]

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See detailStructural Chemistry and Magnetic Properties of Nd18Li8Fe5-xMxO39 (M = Mn, Co),
Dutton, S. E.; Battle, Peter D.; Grandjean, Fernande ULg et al

in Inorganic Chemistry (2009), 48

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See detailMuscular strength, functional performances and injury risk in professional and junior elite soccer players.
Lehance, Cédric ULg; Binet, J.; Bury, Thierry ULg et al

in Scandinavian Journal of Medicine & Science in Sports (2009), 19(2), 243-51

Muscle strength and anaerobic power of the lower extremities are neuromuscular variables that influence performance in many sports activities, including soccer. Despite frequent contradictions in the ... [more ▼]

Muscle strength and anaerobic power of the lower extremities are neuromuscular variables that influence performance in many sports activities, including soccer. Despite frequent contradictions in the literature, it may be assumed that muscle strength and balance play a key role in targeted acute muscle injuries. The purpose of the present study was to provide and compare pre-season muscular strength and power profiles in professional and junior elite soccer players throughout the developmental years of 15-21. One original aspect of our study was that isokinetic data were considered alongside the past history of injury in these players. Fifty-seven elite and junior elite male soccer players were assigned to three groups: PRO, n=19; U-21, n=20 and U-17, n=18. Players benefited from knee flexor and extensor isokinetic testing consisting of concentric and eccentric exercises. A context of lingering muscle disorder was defined using statistically selected cut-offs. Functional performance was evaluated throughout a squat jump and 10 m sprint. The PRO group ran faster and jumped higher than the U-17 group (P<0.05). No significant difference in isokinetic muscle strength performance was observed between the three groups when considering normalized body mass parameters. Individual isokinetic profiles enabled the identification of 32/57 (56%) subjects presenting lower limb muscular imbalance. Thirty-six out of 57 players were identified as having sustained a previous major lower limb injury. Of these 36 players, 23 still showed significant muscular imbalance (64%). New trends in rational training could focus more on the risk of imbalance and implement antagonist strengthening aimed at injury prevention. Such an intervention would benefit not only athletes recovering from injury, but also uninjured players. An interdisciplinary approach involving trainers, a physical coach, and medical staff would be of interest to consider in implementing a prevention programme. [less ▲]

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See detailSubjective evaluation of the long-term efficacy of speech therapy on dysfunctional dysphonia.
Morsomme, Dominique ULg; Faurichon de la Bardonnie, Marie; Verduyckt, Ingrid et al

in Journal of Voice (2009)

The objective of the study was to measure the subjective long-term effects of vocal therapy (more than 6 months) in 29 patients suffering from dysfunctional dysphonia. Four subjective measurements were ... [more ▼]

The objective of the study was to measure the subjective long-term effects of vocal therapy (more than 6 months) in 29 patients suffering from dysfunctional dysphonia. Four subjective measurements were used: one visual analog scale ranging from 0 (not efficient at all) to 100 (very efficient); one question "Is the speech therapy still efficient?," answered by yes or no; the GRB parameters of the GRBAS scale (evaluated by the patient); and the VHI-10. The results show that 76% of the patients consider that the vocal therapy they received is still efficient. On the vocal quality (G), roughness (R), and breathiness (B) parameters, we observe a high degree of satisfaction on the G parameter (median=77). The scores on the R and B parameters are lower (median R=12, S=5). Roughness is significantly correlated to the Grade (Spearman coefficient r=0.516, P=0.004), whereas breathiness is not (P=0.251, NS). The comparison of the results on the VHI-10 pre and post treatment shows a significant decrease in the grade of perceived handicap (medians 15 vs 11, P=0.017). The correlations between the judgment of the treatment's efficacy and the vocal quality is significant (r=0.623, P<0.001) as well as the correlation between the VHI-10 and the length of the treatment (r=0.416, P=0.035). The conclusion can be made that speech therapy plays an important role in long-term treatment of dysfunctional dysphonias. [less ▲]

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See detailConformités des paysages ruraux et parc naturels wallons : l’exemple du parc naturel de la Vallée de l’Attert
Christians, Charles ULg; Schmitz, Serge ULg

in Van Eetvelde, Veerle; Sevenant, Marjanne; Van de Velde, Lisa (Eds.) Re-Marc-able Landscape, Marc-ante Landschappen (2009)

The landscape of a nature park is not a relic landscape but a living cultural landscape. The paper questions the conformity of the landscape in the regional nature park of the Attert valley. It analyses ... [more ▼]

The landscape of a nature park is not a relic landscape but a living cultural landscape. The paper questions the conformity of the landscape in the regional nature park of the Attert valley. It analyses more specifically (1) the conformity to the natural environment and the economic context, (2) the conformity from a semiotic or cultural point of view, and (3) the recognition and the management of the landscape as heritage. It states that few landscape features are preserved from the past. Nevertheless the landscape of the Attert valley maintains an identity due to old settlements, and the influence of the natural environment. The rural policy of renovation since 1970, together with the regional nature park activities, and the coming landscape Charter are useful tools to manage the landscape. However, these tools experience trouble with restraining the increase of real-estate due to the proximity of the Great Duchy of Luxembourg. [less ▲]

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See detailIntentional patina of metal archaeological artefacts; a non-destructive investigation of Egyptian and Roman museum treasures
Mathis, François ULg; Aucouturier, Marc; Robcis, Dominique et al

Conference (2009)

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See detailLa tutelle sur les marchés publics en Région wallonne
Durviaux, Ann-Lawrence ULg

Conference given outside the academic context (2009)

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See detailEffect of membrane permeability on survival of hemodialysis patients
Locatelli, Francesco; Martin-Malo, Alejandro; Hannedouche, Thierry et al

in Journal of the American Society of Nephrology [=JASN] (2009), 20

The effect of high-flux hemodialysis membranes on patient survival has not been unequivocally determined. In this prospective, randomized clinical trial, we enrolled 738 incident hemodialysis patients ... [more ▼]

The effect of high-flux hemodialysis membranes on patient survival has not been unequivocally determined. In this prospective, randomized clinical trial, we enrolled 738 incident hemodialysis patients, stratified them by serum albumin 4 and 4 g/dl, and assigned them to either low-flux or high-flux membranes. We followed patients for 3 to 7.5 yr. Kaplan-Meier survival analysis showed no significant difference between high-flux and low-flux membranes, and a Cox proportional hazards model concurred. Patients with serum albumin 4 g/dl had significantly higher survival rates in the high-flux group compared with the low-flux group (P 0.032). In addition, a secondary analysis revealed that high-flux membranes may significantly improve survival of patients with diabetes. Among those with serum albumin 4 g/dl, slightly different effects among patients with and without diabetes suggested a potential interaction between diabetes status and low serum albumin in the reduction of risk conferred by high-flux membranes. In summary, we did not detect a significant survival benefit with either high-flux or low-flux membranes in the population overall, but the use of high-flux membranes conferred a significant survival benefit among patients with serum albumin 4 g/dl. The apparent survival benefit among patients who have diabetes and are treated with high-flux membranes requires confirmation given the post hoc nature of our analysis. [less ▲]

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See detailWhen morphology and molecules tell us different stories: a case-in-point with Leptodon corsicus, a new and unique endemic moss species from Corsica
Sotiaux A.; Enroth, J.; Quandt, D. et al

in Journal of Bryology (2009), 31

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See detailZoledronic acid and risedronate in the prevention and treatment of glucocorticoid-induced osteoporosis (HORIZON): a multicentre, double-blind, double-dummy, randomised controlled trial.
Reid, David M; Devogelaer, Jean-Pierre; Saag, Kenneth et al

in Lancet (2009), 373(9671), 1253-63

BACKGROUND: Persistent use of glucocorticoid drugs is associated with bone loss and increased fracture risk. Concurrent oral bisphosphonates increase bone mineral density and reduce frequency of vertebral ... [more ▼]

BACKGROUND: Persistent use of glucocorticoid drugs is associated with bone loss and increased fracture risk. Concurrent oral bisphosphonates increase bone mineral density and reduce frequency of vertebral fractures, but are associated with poor compliance and adherence. We aimed to assess whether one intravenous infusion of zoledronic acid was non-inferior to daily oral risedronate for prevention and treatment of glucocorticoid-induced osteoporosis. METHODS: This 1-year randomised, double-blind, double-dummy, non-inferiority study of 54 centres in 12 European countries, Australia, Hong Kong, Israel, and the USA, tested the effectiveness of 5 mg intravenous infusion of zoledronic acid versus 5 mg oral risedronate for prevention and treatment of glucocorticoid-induced osteoporosis. 833 patients were randomised 1:1 to receive zoledronic acid (n=416) or risedronate (n=417). Patients were stratified by sex, and allocated to prevention or treatment subgroups dependent on duration of glucocorticoid use immediately preceding the study. The treatment subgroup consisted of those treated for more than 3 months (272 patients on zoledronic acid and 273 on risedronate), and the prevention subgroup of those treated for less than 3 months (144 patients on each drug). 62 patients did not complete the study because of adverse events, withdrawal of consent, loss to follow-up, death, misrandomisation, or protocol deviation. The primary endpoint was percentage change from baseline in lumbar spine bone mineral density. Drug efficacy was assessed on a modified intention-to-treat basis and safety was assessed on an intention-to-treat basis. This trial is registered with ClinicalTrials.gov, number NCT00100620. FINDINGS: Zoledronic acid was non-inferior and superior to risedronate for increase of lumbar spine bone mineral density in both the treatment (least-squares mean 4.06% [SE 0.28] vs 2.71% [SE 0.28], mean difference 1.36% [95% CI 0.67-2.05], p=0.0001) and prevention (2.60% [0.45] vs 0.64% [0.46], 1.96% [1.04-2.88], p<0.0001) subgroups at 12 months. Adverse events were more frequent in patients given zoledronic acid than in those on risedronate, largely as a result of transient symptoms during the first 3 days after infusion. Serious adverse events were worsening rheumatoid arthritis for the treatment subgroup and pyrexia for the prevention subgroup. INTERPRETATION: A single 5 mg intravenous infusion of zoledronic acid is non-inferior, possibly more effective, and more acceptable to patients than is 5 mg of oral risedronate daily for prevention and treatment of bone loss that is associated with glucocorticoid use. [less ▲]

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See detailLong-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial.
Kahan, Andre; Uebelhart, Daniel; De Vathaire, Florent et al

in Arthritis and Rheumatism (2009), 60(2), 524-33

OBJECTIVE: To assess the long-term effects of chondroitins 4 and 6 sulfate (CS) on the radiographic progression of, and symptom changes associated with, knee osteoarthritis (OA). METHODS: We performed an ... [more ▼]

OBJECTIVE: To assess the long-term effects of chondroitins 4 and 6 sulfate (CS) on the radiographic progression of, and symptom changes associated with, knee osteoarthritis (OA). METHODS: We performed an international, randomized, double-blind, placebo-controlled trial in which 622 patients with knee OA were randomly assigned to receive either 800 mg CS (n = 309 patients) or placebo (n = 313 patients) once daily for 2 years. Radiographs of the target knee, using the Lyon schuss view, were obtained at the time of enrollment and at 12, 18, and 24 months. The minimum joint space width (JSW) of the medial compartment of the tibiofemoral joint was assessed by digital image analysis. The primary outcome was the loss in minimum JSW over 2 years. RESULTS: The intent-to-treat analysis demonstrated a significant reduction (P < 0.0001) in minimum JSW loss in the CS group (mean +/- SEM -0.07 +/- 0.03 mm) as compared with the placebo group (-0.31 +/- 0.04 mm). The percentage of patients with radiographic progression > or =0.25 mm was significantly reduced in the CS group compared with the placebo group (28% versus 41% [P < 0.0005]; relative risk reduction 33% [95% confidence interval 16-46%]). The number of patients needed to treat was 8 (95% confidence interval 5-17). Pain improved significantly faster in the CS group than in the placebo group (P < 0.01). There were no differences in safety between groups. CONCLUSION: The long-term combined structure-modifying and symptom-modifying effects of CS suggest that it could be a disease-modifying agent in patients with knee OA. [less ▲]

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See detailHow precisely will the total cross section be measured at the LHC?
Cudell, Jean-René ULg; Selyugin, O. V.

in Physical Review Letters (2009), 102

It is very likely that hadronic scattering will enter a new regime at the LHC, as the black-disk limit is reached. This will lead to a severe change in the t dependence of the real part and of the slope ... [more ▼]

It is very likely that hadronic scattering will enter a new regime at the LHC, as the black-disk limit is reached. This will lead to a severe change in the t dependence of the real part and of the slope of the elastic scattering amplitude, and in turn this may bias the measurement of the total cross section. We examine this issue, and suggest new strategies to test the reliability of the total cross section measurements. [less ▲]

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See detailExercise-induced oxidative stress in overweight adolescent girls: roles of basal insulin resistance and inflammation and oxygen overconsumption.
Youssef, H.; Groussard, C.; Pincemail, Joël ULg et al

in International Journal of Obesity & Related Metabolic Disorders (2009), 33(4), 447-55

HYPOTHESIS: Basal insulin resistance (IR) and inflammation exacerbate post-exercise oxidative stress (OS) in overweight adolescent girls. DESIGN: Cross-sectional study, effect of incremental ergocycle ... [more ▼]

HYPOTHESIS: Basal insulin resistance (IR) and inflammation exacerbate post-exercise oxidative stress (OS) in overweight adolescent girls. DESIGN: Cross-sectional study, effect of incremental ergocycle exercise until exhaustion on OS markers. PARTICIPANTS: Normal-weight (control) (n=17, body mass index (BMI): 20-24.2 kg/m(2)) and overweight adolescent girls (n=29, BMI: 24.1-36.6 kg/m(2)). MEASUREMENTS: Dietary measurement, physical activity assessment (validated questionnaires), fat distribution parameters (by dual-energy X-ray absorptiometry and anthropometry) and maximal oxygen consumption (VO2peak). Blood assays include the following: (1) at fasting state: blood cell count, lipid profile, and IR parameters (leptin/adiponectin ratio (L/A), homeostasis model assessment of IR, insulin/glucose ratio; (2) before exercise: inflammation and OS markers (interleukin-6 (IL-6), C-reactive protein (CRP), myeloperoxidase (MPO), reduced glutathione/oxidized glutathione ratio (GSH/GSSG), 15 F(2)alpha-isoprostanes (F(2)-Isop), lipid hydroperoxides (ROOH), oxidized low-density lipoprotein (ox-LDL)) and antioxidant status (superoxide dismutase (SOD), glutathione peroxidase (GPX), vitamin C, alpha-tocopherol and beta-carotene); and (3) after exercise: inflammation and OS markers. RESULTS: At rest, overweight girls had a deteriorated lipid profile and significantly higher values of IR parameters and inflammation markers, compared with the control girls. These alterations were associated with a moderate rest OS state (lower GSH/GSSG ratio, alpha-tocopherol/total cholesterol (TC) ratio and GPX activity). In absolute values, overweight girls exhibited higher peak power output and oxygen consumption (VO2peak), compared with the control girls. Exercise exacerbated OS only in the overweight group (significant increase in F(2)-Isop, ROOH and MPO). As hypothesized, basal IR and inflammation state were correlated with the post-exercise OS. However, the adjustment of F(2)-Isop, ROOH and MPO variation per exercise VO(2) variation canceled the intergroup differences. CONCLUSION: In overweight adolescent girls, the main factors of OS, after incremental exhaustive exercise, are not the basal IR and inflammation states, but oxygen overconsumption. [less ▲]

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See detailComparison of two immunoassays for oxidized LDL determination
Le Goff, Caroline ULg; Haleng, Jeanine ULg; Denooz, André ULg et al

in Annales de Biologie Clinique (2009), 67(1),

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See detailDroit international et européen des sociétés
Thirion, Nicolas ULg; Gol, Déborah ULg; Pasteger, David ULg et al

Book published by Larcier (2009)

La multiplication et l’internationalisation des transactions commerciales impliquent une plus grande mobilité des entreprises. Filialisations, délocalisations, création de succursales et d’agences, etc ... [more ▼]

La multiplication et l’internationalisation des transactions commerciales impliquent une plus grande mobilité des entreprises. Filialisations, délocalisations, création de succursales et d’agences, etc., tel est désormais le lot commun de la vie économique. Parallèlement aux migrations des personnes physiques, les déplacements de personnes morales suscitent, eux aussi, un vaste travail de réglementation, non plus seulement au niveau des structures étatiques, mais aussi sur un plan international, voire supranational. C’est cette question de la régulation des sociétés dans l’espace transnational qui constitue l’objet du présent ouvrage. Une première partie de l’ouvrage consiste à identifier les premières dispositions adoptées pour tenir compte de ce phénomène économique, à travers l’étude du droit international, aussi bien privé que public. Une seconde partie examine l’ensemble des règles adoptées au plan de la Communauté européenne dans le même domaine. Les auteurs s’attèlent à décomposer cet ensemble selon la source des dispositions en cause : droit primaire, droit dérivé, jurisprudence de la Cour de justice. Cet ouvrage est l'un des rares en langue française à présenter un panorama significatif des normes applicables à la question de la circulation des sociétés au-delà de leurs frontières d’origine et des problèmes qui en résultent. [less ▲]

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