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See detailEffets de l'inoculation mycorhizienne du substrat sur la croissance et la résistance au stress hydrique de cinq espèces fixatrices de dunes : Acacia raddiana Savi ; Acacia nilotica (L.) Willd. Ex Del. var. adansonii ; Acacia senegal (L.) Willd ; Prosopis chilensis Stunz. et Bauhinia rufescens Lam..
Laminou Manzo, Ousmane; Ibrahim, D.; Campanella, Bruno ULg et al

in Geo-Eco-Trop (2009), 33

Effects of the addition of an indigenous mycorrhizal complex, coming from soils of Gouré and of Glomus intraradices in a non sterile culture substrate were assessed on five woody species, among which 3 ... [more ▼]

Effects of the addition of an indigenous mycorrhizal complex, coming from soils of Gouré and of Glomus intraradices in a non sterile culture substrate were assessed on five woody species, among which 3 acacias (A. nilotica, A. raddiana, A. senegal), Bauhinia rufescens and Prosopis chilensis, in a tree nursery and on a sand dune of Gouré. In the nursery, species underwent a water stress by interrupting the watering during six days. Foliar hydration has been determined in order to evaluate the respective effects of the mycorrhizal inoculation for water loss limitation. Mycorrhizal root colonization has been determined as well as plant height and total biomass. In a field experiment, inoculated and non inoculated species have been planted on a mechanically prefixed sand dune portion in order to evaluate the effects of mycorrhizal inoculations on growth in the field. Results in nursery showed that (i) the non sterile soil would contain some endogenous AMF (arbuscular mycorrhizal fungi) as infectious as those in soils with mycorrhizal additions; (ii) addition of Glomus intraradices would be efficient to stimulate total biomass and (iii) natural mycorhization would be as efficient as both mycorrhizal addition for growth stimulation and water loss limitation by transpiration. Results on site confirm the comparable effectiveness of the natural mycorhization and mycorrhizal additions. Although the addition of G. intraradices appears to be slightly superior by some aspects on some species, the observed effects do not justify preferring it, when compared to indigenous composite inoculum or to natural mycorhization in this zone. [less ▲]

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See detailMatrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?
Garbacki, Nancy ULg; Di Valentin, Emmanuel ULg; Piette, Jacques ULg et al

in Pulmonary Pharmacology & Therapeutics (2009), 22(4), 267-278

Among the large matrix metalloproteinases (MMPs) family, MMP-12, also referred to as macrophage elastase, plays a significant role in chronic pulmonary pathologies characterized by an intense tissue ... [more ▼]

Among the large matrix metalloproteinases (MMPs) family, MMP-12, also referred to as macrophage elastase, plays a significant role in chronic pulmonary pathologies characterized by an intense tissue remodeling such as asthma and COPD. This review will summarize knowledge about MMP-12 structure, functions and mechanisms of activation and regulation, including potential MMP-12 modulation by microRNA. As MMP-12 is involved in many tissue remodeling diseases, efforts have been made to develop specific synthetic inhibitors. However, at this time, very few chemical inhibitors have proved to be efficient and specific to a particular MMP. The relevance of silencing MMP-12 by RNA interference is highlighted. The specificity of this approach using siRNA or shRNA and the strategies to deliver these molecules in the lung are discussed. [less ▲]

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See detailMachine Perfusion or cold storage in deceased-donor kidney transplantation
Moers, C.; Smits, J.; Maathuis, M. H. et al

in New England Journal of Medicine [=NEJM] (2009), 360

BACKGROUND Static cold storage is generally used to preserve kidney allografts from deceased donors. Hypothermic machine perfusion may improve outcomes after transplantation, but few sufficiently powered ... [more ▼]

BACKGROUND Static cold storage is generally used to preserve kidney allografts from deceased donors. Hypothermic machine perfusion may improve outcomes after transplantation, but few sufficiently powered prospective studies have addressed this possibility. METHODS In this international randomized, controlled trial, we randomly assigned one kidney from 336 consecutive deceased donors to machine perfusion and the other to cold storage. All 672 recipients were followed for 1 year. The primary end point was delayed graft function (requiring dialysis in the first week after transplantation). Secondary end points were the duration of delayed graft function, delayed graft function defined by the rate of the decrease in the serum creatinine level, primary nonfunction, the serum creatinine level and clearance, acute rejection, toxicity of the calcineurin inhibitor, the length of hospital stay, and allograft and patient survival. RESULTS Machine perfusion significantly reduced the risk of delayed graft function. Delayed graft function developed in 70 patients in the machine-perfusion group versus 89 in the cold-storage group (adjusted odds ratio, 0.57; P = 0.01). Machine perfusion also significantly improved the rate of the decrease in the serum creatinine level and reduced the duration of delayed graft function. Machine perfusion was associated with lower serum creatinine levels during the first 2 weeks after transplantation and a reduced risk of graft failure (hazard ratio, 0.52; P = 0.03). One-year allograft survival was superior in the machine-perfusion group (94% vs. 90%, P = 0.04). No significant differences were observed for the other secondary end points. No serious adverse events were directly attributable to machine perfusion. CONCLUSIONS Hypothermic machine perfusion was associated with a reduced risk of delayed graft function and improved graft survival in the first year after transplantation. (Current Controlled Trials number, ISRCTN83876362.) [less ▲]

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See detailForeword
Defourny, Jacques ULg

in Kerlin, Janelle A. (Ed.) Social Enterprise. A Global Comparison (2009)

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See detailTechnologies de l'Information et de la Communication pour l'Éducation et la Formation en contexte scolaire (TIC-EF)
Denis, Brigitte ULg

Learning material (2009)

Le cours comprend les chapitres suivants : 1. Approche systémique de la formation initiale et continue des enseignants aux usages des TICE 2. Analyse d’activités de formation/apprentissage recourant aux ... [more ▼]

Le cours comprend les chapitres suivants : 1. Approche systémique de la formation initiale et continue des enseignants aux usages des TICE 2. Analyse d’activités de formation/apprentissage recourant aux TIC et discussion de leurs apports à l’enseignement 3. Analyse de dispositifs de formation recourant aux TIC sous l’angle de l’innovation 4. Évaluation de la qualité ergonomique et pédagogique de produits multimédias et de sites Web éducatifs 5. Création de scénarios pédagogiques intégrant les TIC 6. Problématiques d’évaluation et leur instrumentation à l’aide des TIC [less ▲]

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See detailBelRAI : recherche-action ayant pour mission préparation de l'implémentation de la démarche RAI en Belgique
Declercq, A; Gosset, Christiane ULg; de Almeida Mello, J et al

Report (2009)

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See detailCriminologie en criminaliteitsbeleid: tussen mensenrechten en doeltreffende criminaliteitsbeheersing
Lauwaert, Katrien ULg; Wolthuis, Annemieke

in Tijdschrift voor Herstelrecht (2009), 9(3), 65-72

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See detailMassive stars and emission-line stars with GAIA
Blomme, Ronny; Frémat, Y.; Lobel, Alex et al

Poster (2009)

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See detailEvidence-based guidelines for the use of biochemical markers of bone turnover in the selection and monitoring of bisphosphonate treatment in osteoporosis: a consensus document of the Belgian Bone Club.
Bergmann, Pierre; Body, Jean-Jacques; Boonen, Steven et al

in International Journal of Clinical Practice (2009), 63(1), 19-26

OBJECTIVES: To review the clinical value of bone turnover markers (BTM), to initiate and/or monitor anti-resorptive treatment for osteoporosis compared with bone mineral density (BMD) and to evaluate ... [more ▼]

OBJECTIVES: To review the clinical value of bone turnover markers (BTM), to initiate and/or monitor anti-resorptive treatment for osteoporosis compared with bone mineral density (BMD) and to evaluate suitable BTM and changes in BTM levels for significance of treatment efficiency. METHODOLOGY: Consensus meeting generating guidelines for clinical practice after review and discussion of the randomised controlled trials or meta-analyses on the management of osteoporosis in postmenopausal women. RESULTS: Although the correlation between BMD and BTM is statistically significant, BTM cannot be used as predictive markers of BMD in an individual patient. Both are independent predictors of fracture risk, but BTM can only be used as an additional risk factor in the decision to treat. Current data do not support the use of BTM to select the optimal treatment. However, they can be used to monitor treatment efficiency before BMD changes can be evaluated. Early changes in BTM can be used to measure the clinical efficacy of an anti-resorptive treatment and to reinforce patient compliance. DISCUSSION: Determining a threshold of BTM reflecting an optimal long-term effect is not obvious. The objective should be the return to the premenopausal range and/or a decrease at least equal to the least significant change (30%). Preanalytical and analytical variability of BTM is an important limitation to their use. Serum C-terminal cross-linked telopeptide of type I collagen (CTX), procollagen 1 N terminal extension peptide and bone specific alkaline phosphatase (BSALP) appear to be the most suitable. Conclusion: Consensus regarding the use of BTM resulted in guidelines for clinical practice. BMD determines the indication to treat osteoporosis. BTM reflect treatment efficiency and can be used to motivate patients to persist with their medication. [less ▲]

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See detailThe use of Macronet resins to recover γ-decalactone produced by Rhodotorula aurantiaca from the culture broth
Alchihab, Mohamed ULg; Destain, Jacqueline ULg; Aguedo, Mario ULg et al

Poster (2009)

The objective of this study was to recover the γ-decalactone produced by R. aurantiaca from the culture broth using three Macronet resins (MN-100, MN-102 and MN-202).

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See detailVariability of major fatty acid contents in Luxembourg dairy cattle
Soyeurt, Hélène ULg; Arnould, Valérie ULg; Dardenne, Pierre et al

in Book of Abstracts of the 60th Annual Meeting of the European Association for Animal Production (2009)

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See detailFaciogenital dysplasia protein Fgd1 regulates invadopodia biogenesis and extracellular matrix degradation and is up-regulated in prostate and breast cancer.
Ayala, Inmaculada; Giacchetti, Giada; Caldieri, Giusi et al

in Cancer Research (2009), 69(3), 747-52

Invadopodia are proteolytically active membrane protrusions that extend from the ventral surface of invasive tumoral cells grown on an extracellular matrix (ECM). The core machinery controlling ... [more ▼]

Invadopodia are proteolytically active membrane protrusions that extend from the ventral surface of invasive tumoral cells grown on an extracellular matrix (ECM). The core machinery controlling invadopodia biogenesis is regulated by the Rho GTPase Cdc42. To understand the upstream events regulating invadopodia biogenesis, we investigated the role of Fgd1, a Cdc42-specific guanine nucleotide exchange factor. Loss of Fgd1 causes the rare inherited human developmental disease faciogenital dysplasia. Here, we show that Fgd1 is required for invadopodia biogenesis and ECM degradation in an invasive cell model and functions by modulation of Cdc42 activation. We also find that Fgd1 is expressed in human prostate and breast cancer as opposed to normal tissue and that expression levels matched tumor aggressiveness. Our findings suggest a central role for Fgd1 in the focal degradation of the ECM in vitro and, for the first time, show a connection between Fgd1 and cancer progression, proposing that it might function during tumorigenesis. [less ▲]

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See detailReaching the schools
Nazé, Yaël ULg

Poster (2009)

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See detailEx vivo expansion of hematopoietic progenitor cells is associated with downregulation of alpha4 integrin- and CXCR4-mediated engraftment in NOD/SCID beta2-microglobulin-null mice
Foguenne, Jacques ULg; Di Stefano; Giet, Olivier ULg et al

in Haematologica (2009), 94

Several studies indicate that ex vivo cytokine-supported expansion induces defective hematopoietic stem cell engraftment. We investigated the role of alpha4 integrin, alpha5 integrin and CXCR4 in ... [more ▼]

Several studies indicate that ex vivo cytokine-supported expansion induces defective hematopoietic stem cell engraftment. We investigated the role of alpha4 integrin, alpha5 integrin and CXCR4 in engraftment of unmanipulated and cytokine-treated human cord blood CD34+ cells. [less ▲]

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See detailWho's in charge? Nuclear receptor coactivator and corepressor function in brain and behavior.
Tetel, M. J.; Auger, A. P.; Charlier, Thierry ULg

in Frontiers in Neuroendocrinology (2009), 30

Steroid hormones act in brain and throughout the body to regulate a variety of functions, including development, reproduction, stress and behavior. Many of these effects of steroid hormones are mediated ... [more ▼]

Steroid hormones act in brain and throughout the body to regulate a variety of functions, including development, reproduction, stress and behavior. Many of these effects of steroid hormones are mediated by their respective receptors, which are members of the steroid/nuclear receptor superfamily of transcriptional activators. A variety of studies in cell lines reveal that nuclear receptor coregulators are critical in modulating steroid receptor-dependent transcription. Thus, in addition to the availability of the hormone and the expression of its receptor, nuclear receptor coregulators are essential for efficient steroid-dependent transactivation of genes. This review will highlight the importance of nuclear receptor coregulators in modulating steroid-dependent gene expression in brain and the regulation of behavior. [less ▲]

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See detailLarge scale experimental study of piano key weirs
Machiels, Olivier ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Proc. 33rd IAHR Congress: Water Engineering for a Sustainable Environment (2009)

Piano Key Weirs (PKW) are a new type of weir, showing very good flood release capacities as well as strong economic and structural benefits. However, lacks of understanding persist about the flow ... [more ▼]

Piano Key Weirs (PKW) are a new type of weir, showing very good flood release capacities as well as strong economic and structural benefits. However, lacks of understanding persist about the flow conditions on such structures. With the goal to fill some of these lacks, a combined experimental and numerical study has been undertaken at the Laboratory of Structures Hydraulics of the University of Liege. This paper presents the goals and the scientific strategy of this research. The first results of experiments being carried out on a large physical model of PKW are also depicted. These experiments lead to characterization of the flow behavior for low heads and enable to highlight the influence of the crest thickness and the outlet slope on the release capacity. [less ▲]

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See detailLes marchés publics par l'analyse de cas : n°1 à 10
Durviaux, Ann-Lawrence ULg; Simar, Renaud ULg

Learning material (2009)

support écrit des travaux pratiques sous forme de casus et de propositions de résolution

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See detailFeline herpesvirus infection. ABCD guidelines on prevention and management
Thiry, Etienne ULg; Addie, D.; Belak, B. et al

in Journal of Feline Medicine and Surgery (2009), 11

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See detailGuideline for resuscitation in cardiac arrest after cardiac surgery.
Dunning, Joel; Fabbri, Alessandro; Kolh, Philippe ULg et al

in European Journal of Cardio - Thoracic Surgery (2009), 36(1), 3-28

The Clinical Guidelines Committee of the European Association for Cardio-Thoracic Surgery provides this professional view on resuscitation in cardiac arrest after cardiac surgery. This document was ... [more ▼]

The Clinical Guidelines Committee of the European Association for Cardio-Thoracic Surgery provides this professional view on resuscitation in cardiac arrest after cardiac surgery. This document was created using a multimodal methodology for evidence generation including the extrapolation of existing guidelines from the International Liaison Committee on Resuscitation where possible, our own structured literature reviews on issues particular to cardiac surgery, an international survey on resuscitation hosted by CTSNet and manikin simulations of potential protocols. This protocol differs from existing generic guidelines in a number of areas, the most import of which are the following: successful treatment of cardiac arrest after cardiac surgery is a multi-practitioner activity with six key roles that should be allocated and rehearsed on a regular basis; in ventricular fibrillation, three sequential attempts at defibrillation (where immediately available) should precede external cardiac massage; in asystole or extreme bradycardia, pacing (where immediately available) should precede external cardiac massage; where the above measures fail, and in pulseless electrical activity, early resternotomy is advocated; adrenaline should not be routinely given; protocols for excluding reversible airway and breathing complications and for safe emergency resternotomy are given. This guideline is subject to continuous informal review, and when new evidence becomes available. [less ▲]

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