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See detailNouvelles courbes de productivité pour le douglas en Région wallonne
Perin, Jérôme ULg; Claessens, Hugues ULg; Hebert, Jacques ULg

in Forêt Wallonne (2009), (98), 22-28

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See detailDes indicateurs du développement professionnel basés sur la conceptualisation de l’action ? Apports d’une expérimentation qualitative sur l’utilisation professionnelle d’un traitement de texte.
Chenu, Florent ULg

in Actes du 21e Colloque de l’Associtation pour le Développement des Méthodologies d'Evaluation en Education : Développement Professionnel et évaluation. Université Catholique de Louvain-la-Neuve, Belgique, Janvier 2009. (2009)

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See detailDevelopment of an animal experimental model to study the effects of levonorgestrel on the human endometrium.
Alvarez Gonzalez, Maria-Luz ULg; Galant, C.; Frankenne, F. et al

in Human Reproduction (2009), 24(3), 697-704

BACKGROUND: This study was designed to develop an animal model to test the response of endometrium to local progestin delivery. METHODS: Proliferative human endometrium was subcutaneously grafted in two ... [more ▼]

BACKGROUND: This study was designed to develop an animal model to test the response of endometrium to local progestin delivery. METHODS: Proliferative human endometrium was subcutaneously grafted in two groups of SCID mice that received, 2 days before, a subcutaneous estradiol (E2) pellet and, for half of them, an additional implant of levonorgestrel (LNG). Mice were sacrificed 1, 2, 3 or 4 weeks after endometrial implantation and grafts were histologically analysed. Proliferation, steroid hormone receptors, blood vessels and stromal decidualization in both groups (E2 and LNG) were immunohistologically evaluated and compared with proliferative endometrium and endometrium from women with an LNG intrauterine device. RESULTS: Grafts presented normal morphological endometrial characteristics. The expression of progesterone receptors was significantly decreased in glands and stroma of the LNG group as compared with the E2 group at all times. A significant decrease was also observed in the stromal expression of estrogen receptor- in the LNG group. At 4 weeks, the mean cross-sectional area of vessels was significantly higher after LNG treatment. CONCLUSIONS: These morphological and immunohistochemical characteristics are similar to those observed in women treated with local LNG. This mouse model might facilitate further investigations needed to understand the mechanisms responsible for the breakthrough bleeding frequently observed in progestin users. [less ▲]

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See detailFrom paradigm dynamics towards landscape ecology ontogenesis
Bogaert, Jan ULg

in Farina, A. (Ed.) Ecology, Cognition and Landscape: Linking Natural and Social Systems. Landscape series 11. (2009)

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See detailCellular source and amount of vascular endothelial growth factor and platelet-derived growth factor in tumors determine response to angiogenesis inhibitors.
Sennino, Barbara; Kuhnert, Frank; Tabruyn, Sébastien ULg et al

in Cancer Research (2009), 69(10), 4527-36

Vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and their receptors are important targets in cancer therapy based on angiogenesis inhibition. However, it is unclear ... [more ▼]

Vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and their receptors are important targets in cancer therapy based on angiogenesis inhibition. However, it is unclear whether inhibition of VEGF and PDGF together is more effective than inhibition of either one alone. Here, we used two contrasting tumor models to compare the effects of inhibiting VEGF or PDGF alone, by adenovirally generated soluble receptors, to the effects of inhibiting both together. In RIP-Tag2 tumors, VEGF and PDGF inhibition together reduced tumor vascularity and abundance of pericytes. However, VEGF inhibition reduced tumor vascularity without decreasing pericyte density, and PDGF inhibition reduced pericytes without reducing tumor vascularity. By contrast, in Lewis lung carcinomas (LLC), inhibition of VEGF or PDGF reduced blood vessels and pericytes to the same extent as did inhibition of both together. Similar results were obtained using tyrosine kinase inhibitors AG-013736 and imatinib. In LLC, VEGF expression was largely restricted to pericytes and PDGF was largely restricted to endothelial cells, but, in RIP-Tag2 tumors, expression of both growth factors was more widespread and significantly greater than in LLC. These findings suggest that inhibition of PDGF in LLC reduced pericytes, and then tumor vessels regressed because pericytes were the main source of VEGF. The vasculature of RIP-Tag2 tumors, in which most VEGF is from tumor cells, was more resistant to PDGF inhibition. The findings emphasize the interdependence of pericytes and endothelial cells in tumors and the importance of tumor phenotype in determining the cellular effects of VEGF and PDGF inhibitors on tumor vessels. [less ▲]

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See detailInfluence de l'apport énergétique et de l'hibernation sur la croissance des tortues terrestres
Diez, Marianne ULg; Justet, Delphine; Detilleux, Johann ULg et al

in 15th FECAVA Eurocongress - Proceedings (2009)

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See detailAlcool et nid vide. Récit d’un travail thérapeutique avec un couple en crise de transition.
D'Amore, Salvatore ULg

in Cahiers Critiques de Thérapie Familiale et de Pratique des Réseaux (2009), 49(1), 231-254

ecent theoretical and clinical contributions on old age couples with one alcohol-dependent member underline the need for a pragmatic-interactive and semantic-symbolic approach of the issue. In particular ... [more ▼]

ecent theoretical and clinical contributions on old age couples with one alcohol-dependent member underline the need for a pragmatic-interactive and semantic-symbolic approach of the issue. In particular, alcohol dependence should be read in the light of specific developmental tasks, resources and constraints corresponding to old age couples’ lifecycle. This paper proposes the example of a psychotherapeutic work of a couple with one alcohol-dependent member, through the following stages : control of the alcoholic symptom, account of personal and family history, renegotiation/reformulation of the couple’s spaces/times. Thanks to the progressive dissolution of the symptom, the individual, couple and family’s project has been re-launched : an essential point to better the old-aged couple’s quality of life. [less ▲]

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See detailSimplifier les interfaces utilisateurs
Nyssen, Anne-Sophie ULg

Conference (2009)

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See detailEvaluation biologique du stress oxydant : application en routine clinique.
Pincemail, Joël ULg; Le Goff, Caroline ULg; Charlier, Corinne ULg et al

in Nutritions & Endocrinologie (2009), Déc

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See detailApport de la neuro-imagerie fonctionnelle à l'étude de la douleur
Fontaine, Robert ULg; Vanhaudenhuyse, Audrey ULg; Demertzi, Athina ULg et al

in Revue du Rhumatisme (2009), 76

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See detailProduction and toxicity of γ-decalactone and 4-hydroxydecanoic acid from Rhodotorula aurantiaca
Alchihab, Mohamed ULg; Destain, Jacqueline ULg; Aguedo, Mario ULg et al

Poster (2009)

The objective of this study was to compare the production of γ- decalactone in different scales and to study the effects of 4- hydroxydecanoic acid and γ-decalactone on the growth of R. aurantiaca. The ... [more ▼]

The objective of this study was to compare the production of γ- decalactone in different scales and to study the effects of 4- hydroxydecanoic acid and γ-decalactone on the growth of R. aurantiaca. The effect of gum tragacanth on the production of γ-decalactone by R. aurantiaca was evaluated. [less ▲]

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See detailReptile cell cultures for nucleolar studies
Lamaye, Françoise; Thiry, Marc ULg

Poster (2009)

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See detailDe nouveaux enjeux sur l’espace : la délimitation des premières forêts communautaires au Gabon
Vermeulen, Cédric ULg; Schippers, C.; Ndouna, A. A. et al

in International Journal of Biological and Chemical Sciences (2009), 3(5), 1171-1181

Le Gabon s’est doté il y a quelques années d’une nouvelle loi forestière intégrant les populations locales dans la gestion durable des massifs forestiers à travers le concept de « forêts communautaires » ... [more ▼]

Le Gabon s’est doté il y a quelques années d’une nouvelle loi forestière intégrant les populations locales dans la gestion durable des massifs forestiers à travers le concept de « forêts communautaires ». L’une des premières étapes dans la mise en place de ces forêts communautaires est la délimitation de celles-ci. Cet article aborde le cas concret de la délimitation d’une première forêt communautaire dans ce pays, le cas du regroupement de villages de Ebe Messe Melane. La délimitation suit une approche intégrée afin de concilier d’une part les contraintes légales et d’autre part l’occupation de l’espace actuelle par les populations villageoises. Cet exemple permet d’illustrer les différents enjeux que soulève la délimitation des forêts communautaires. Des enjeux spatiaux, financiers ou identitaires qui impliquent les acteurs aux intérêts parfois divergents que sont les communautés villageoises, l’Etat et les opérateurs forestiers privés. [less ▲]

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See detailMicrobial biomass and C and N transformations in forest floors under European beech, sessile oak, Norway spruce and Douglas-fir at four temperate forest sites
Malchair, Sandrine ULg; Carnol, Monique ULg

in Soil Biology & Biochemistry (2009), 41

The purpose of this research was to compare soil chemistry, microbially mediated carbon (C) and nitrogen (N) transformations and microbial biomass in forest floors under European beech (Fagus sylvatica L ... [more ▼]

The purpose of this research was to compare soil chemistry, microbially mediated carbon (C) and nitrogen (N) transformations and microbial biomass in forest floors under European beech (Fagus sylvatica L), sessile oak (Quercus petraea (Mattuschka) Lieblein), Norway spruce (Picea abies (L) Karst) and Douglas-fir (Pseudotsuga menziesii (Mirbel) Franco) at four study sites. We measured soil chemical characteristics, net N mineralization, potential and relative nitrification, basal respiration, microbial and metabolic quotient and microbial biomass C and N under monoculture stands at all sites (one mixed stand). Tree species affected soil chemistry, microbial activities and biomass. but these effects 'varied between sites. Our results indicated that the effect of tree species on net N mineralization was likely to be mediated through their effect on soil microbial biomass, reflecting their influence on organic matter content and carbon availability. Differences in potential nitrification and relative nitrification might be related to the presence of ground vegetation through its influence on soil NH4 and labile C availability. Our findings highlight the need to study the effects of tree species on microbial activities at several sites to elucidate complex N cycle interactions between tree species, ground vegetation, soil characteristics and microbial processes. (C) 2009 Elsevier Ltd. All rights reserved. [less ▲]

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See detailProspects for Near-infrared Characterisation of Hot Jupiters with the VLTI Spectro-imager (VSI)
Renard, Stéphanie; Absil, Olivier ULg; Berger, Jean-Philippe et al

in Moorwood, A. (Ed.) Science with the VLT in the ELT Era (2009)

Since the discovery of the first exoplanet around 51 Pegasi, the study of planetary systems receives an increasing attention, with the development and test of more and more detection techniques. Among the ... [more ▼]

Since the discovery of the first exoplanet around 51 Pegasi, the study of planetary systems receives an increasing attention, with the development and test of more and more detection techniques. Among the direct detection techniques, interferometry is one of the most promising for the near future. It already provides the required angular resolution, but the dynamic range needs to be improved. The detection and characterisation of extrasolar planets is one of the main science cases of the 2nd generation VLTI Spectro-Imager instrument (VSI). The goal of this work is to study the feasibility of obtaining near-infrared spectra of bright extrasolar giant planets (EGP) with VSI. [less ▲]

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See detailGenetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis.
Villani, Alexandra-Chloé; Lemire, Mathieu; Louis, Edouard ULg et al

in PLoS ONE (2009), 4(9), 7154

BACKGROUND AND AIMS: The familial Mediterranean fever (FMF) gene (MEFV) encodes pyrin, a major regulator of the inflammasome platform controlling caspase-1 activation and IL-1beta processing. Pyrin has ... [more ▼]

BACKGROUND AND AIMS: The familial Mediterranean fever (FMF) gene (MEFV) encodes pyrin, a major regulator of the inflammasome platform controlling caspase-1 activation and IL-1beta processing. Pyrin has been shown to interact with the gene product of NLRP3, NALP3/cryopyrin, also an important active member of the inflammasome. The NLRP3 region was recently reported to be associated with Crohn's disease (CD) susceptibility. We therefore sought to evaluate MEFV as an inflammatory bowel disease (IBD) susceptibility gene. METHODOLOGY AND RESULTS: MEFV colonic mucosal gene expression was significantly increased in experimental colitis mice models (TNBS p<0.0003; DSS p<0.006), in biopsies from CD (p<0.02) and severe ulcerative colitis (UC) patients (p<0.008). Comprehensive genetic screening of the MEFV region in the Belgian exploratory sample set (440 CD trios, 137 UC trios, 239 CD cases, 96 UC cases, and 107 healthy controls) identified SNPs located in the MEFV 5' haplotype block that were significantly associated with UC (rs224217; p = 0.003; A allele frequency: 56% cases, 45% controls), while no CD associations were observed. Sequencing and subsequent genotyping of variants located in this associated haplotype block identified three synonymous variants (D102D/rs224225, G138G/rs224224, A165A/rs224223) and one non-synonymous variant (R202Q/rs224222) located in MEFV exon 2 that were significantly associated with UC (rs224222: p = 0.0005; A allele frequency: 32% in cases, 23% in controls). No consistent associations were observed in additional Canadian (256 CD trios, 91 UC trios) and Scottish (495 UC, 370 controls) sample sets. We note that rs224222 showed marginal association (p = 0.012; G allele frequency: 82% in cases, 70% in controls) in the Canadian sample, but with a different risk allele. None of the NLRP3 common variants were associated with UC in the Belgian-Canadian UC samples and no significant interactions were observed between NLRP3 and MEFV that could explain the observed flip-flop of the rs224222 risk allele. CONCLUSION: The differences in association levels observed between the sample sets may be a consequence of distinct founder effects or of the relative small sample size of the cohorts evaluated in this study. However, the results suggest that common variants in the MEFV region do not contribute to CD and UC susceptibility. [less ▲]

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See detailA few thoughts about representative actions
Sibony, Anne-Lise ULg

in Gheur, Charles; Petit, Nicolas (Eds.) Alternative enforcement techniques in EC Competition law: Settlement, commitments and other novel instruments (2009)

These brief remarks (originally made as a panel member commenting on other speaker's views) touch on two elementary questions regarding representative actions envisaged in the Commission's White Paper on ... [more ▼]

These brief remarks (originally made as a panel member commenting on other speaker's views) touch on two elementary questions regarding representative actions envisaged in the Commission's White Paper on Damages Actions for Breach of the EC antitrust rules. The first question adressed is "who will represent whom?". On this aspect, an analogy is drawn with the proposed directive on access to justice in environmental law matters. The second issue concerns conflicting preferences of consumers and corporate defendants regarding publicity of proceedings in which consumer's claims for damages are adjudicated. [less ▲]

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