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See detailIn vivo importance of heparan sulfate-binding glycoproteins for murid herpesvirus-4 infection.
Gillet, Laurent ULg; May, Janet S; Stevenson, Philip G

in Journal of General Virology (The) (2009), 90(Pt 3), 602-13

Many herpesviruses bind to heparan sulfate (HS). Murid herpesvirus-4 (MuHV-4) does so via its envelope glycoproteins gp70 and gH/gL. MuHV-4 gp150 further regulates an HS-independent interaction to make ... [more ▼]

Many herpesviruses bind to heparan sulfate (HS). Murid herpesvirus-4 (MuHV-4) does so via its envelope glycoproteins gp70 and gH/gL. MuHV-4 gp150 further regulates an HS-independent interaction to make that HS-dependent too. Cell binding by MuHV-4 virions is consequently strongly HS-dependent. Gp70 and gH/gL show some in vitro redundancy: an antibody-mediated blockade of HS binding by one is well tolerated, whereas a blockade of both severely impairs infection. In order to understand the importance of HS binding for MuHV-4 in vivo, we generated mutants lacking both gL and gp70. As expected, gL(-)gp70(-) MuHV-4 showed very poor cell binding. It infected mice at high dose but not at low dose, indicating defective host entry. But once entry occurred, host colonization, which for MuHV-4 is relatively independent of the infection dose, was remarkably normal. The gL(-)gp70(-) entry deficit was much greater than that of gL(-) or gp70(-) single knockouts. And gp150 disruption, which allows HS-independent cell binding, largely rescued the gL(-)gp70(-) cell binding and host entry deficits. Thus, it appeared that MuHV-4 HS binding is important in vivo, principally for efficient host entry. [less ▲]

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See detailDynamics of the negative thermal expansion in tellurium based liquid alloys
Otjacques, C.; Raty, Jean-Yves ULg; Coulet, M-V et al

in Physical Review Letters (2009), 103(24), 2459014-24590142459014

Negative thermal expansion (NTE) in tellurium based liquid alloys (GeTe 6 and GeTe 12) is analyzed through the atomic vibrational properties. Using neutron inelastic scattering, we show that the ... [more ▼]

Negative thermal expansion (NTE) in tellurium based liquid alloys (GeTe 6 and GeTe 12) is analyzed through the atomic vibrational properties. Using neutron inelastic scattering, we show that the structural evolution resulting in the NTE is due to a gain of vibrational entropy that cancels out the Peierls distortion. In the NTE temperature range, these competing effects give rise to noticeable changes in the vibrational density of states spectra. Additional first principles molecular dynamics simulations emphasize the role of the temperature dependance of the Ge atomic environment in this mechanism. For comparison, we extended our study to Ge 2Sb 2Te 5 and Ge 1Sb 2Te 4 phase-change materials. [less ▲]

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See detailLes matières colorantes au début du Paléolithique supérieur : sources, transformations et fonctions
Salomon, Hélène ULg

Doctoral thesis (2009)

Abstract : Despite an increasing number of studies, colouring materials are still poorly understood among excavation remains. Their attraction lies in their capacity to bring to light diverse and complex ... [more ▼]

Abstract : Despite an increasing number of studies, colouring materials are still poorly understood among excavation remains. Their attraction lies in their capacity to bring to light diverse and complex skills, but also in their intense colouring power and their contrasting colours : red and black, which still possess a symbolic value. These highly symbolic materials may, therefore, highlight the “conceptual” practices of prehistoric men and give access to their symbolic world and thought. In such a particular context as the transition between the Middle and the Upper Palaeolithic, these remains, which are very abundant in most excavations, offer the possibility, through analysis, to get an exceptional insight into the way of life of the last Neanderthals. The Châtelperronian site of the “Grotte du Renne”, in Arcy-sur-Cure (Yonne), is a landmark. It was excavated beween 1949 and 1963 by André Leroi-Gourhan : Numerous colouring materials were discovered there, and Leroi-Gourhan developed theories about their transformation and uses which so far have not been tested, and have remained unchallenged.Since their discovery, the assumption is that those minerals were heated in a controlled way, in order to modify their colour. It is indeed well-known that heat transforms yellow materials (iron hydroxides) in orange, red or purple materials (iron oxides). From this hypothesis originates the theory according to which Neanderthals exploited colouring materials as pigments for symbolic or even aesthetic purposes. But the theory has so far never been proved true. Our study combines several sets of data, obtained from different methods. Physico-chemical and petrological analyses were carried out on the colouring materials. These data were related to their location on the site, in association with exceptionally well preserved “hut” structures. Furthermore, a series of experimentations, aimed to characterize powders obtained via different methods (grinding and crushing on the one hand, abrasion on the other hand). The comparison of all these data enabled us to identify the various technical choices which informed the supply in colouring minerals in all the Châtelperronian levels of the Grotte du Renne. It was thus possible to demonstrate that none of these materials, either red or black, was heated before being used, contrary to what had been assumed so far. The supply in colouring materials was as carefully organised as for other materials (flint, for example) ; they were collected in geological formations occasionally showing on the surface, at more than 10 km from the cave. The exploitation of these geological sites did not vary during the whole Châtelperronian period, and privileged materials which can easily be ground into powder. Part of their supply was ground coarsely in order to cover large surface areas (soils or hides) as preservative or to clean them up. The remaining materials were destined to more meticulous activities, which required a fine, regular, and highly-colouring powder. In this latter case, the Neanderthals of the Grotte du Renne used those products when working on bone materials (bone or mammoth ivory), and used them also for their sheer colour. The set of colouring minerals from the Grotte du Renne reveals Neanderthals’ in-depth knowledge of materials ; they understood perfectly well their properties and qualities, and used them extensively, so that the Châtelperronian site must have been a literally dazzling sight, all red and black. The “chaîne opératoire” which transpires from our analysis shows very sophisticated techniques, and an advanced “technological” knowledge. They are witness to surprising capacities and a highly-evolved pattern of thought. [less ▲]

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See detailImpaired semantic knowledge underlies the reduced verbal short-term storage capacity in Alzheimer's disease.
Peters, Frederic; Majerus, Steve ULg; De Baerdemaeker, Julie et al

in Neuropsychologia (2009), 47(14), 3067-73

A decrease in verbal short-term memory (STM) capacity is consistently observed in patients with Alzheimer's disease (AD). Although this impairment has been mainly attributed to attentional deficits during ... [more ▼]

A decrease in verbal short-term memory (STM) capacity is consistently observed in patients with Alzheimer's disease (AD). Although this impairment has been mainly attributed to attentional deficits during encoding and maintenance, the progressive deterioration of semantic knowledge in early stages of AD may also be an important determinant of poor STM performance. The aim of this study was to examine the influence of semantic knowledge on verbal short-term memory storage capacity in normal aging and in AD by exploring the impact of word imageability on STM performance. Sixteen patients suffering from mild AD, 16 healthy elderly subjects and 16 young subjects performed an immediate serial recall task using word lists containing high or low imageability words. All participant groups recalled more high imageability words than low imageability words, but the effect of word imageability on verbal STM was greater in AD patients than in both the young and the elderly control groups. More precisely, AD patients showed a marked decrease in STM performance when presented with lists of low imageability words, whereas recall of high imageability words was relatively well preserved. Furthermore, AD patients displayed an abnormal proportion of phonological errors in the low imageability condition. Overall, these results indicate that the support of semantic knowledge on STM performance was impaired for lists of low imageability words in AD patients. More generally, these findings suggest that the deterioration of semantic knowledge is partly responsible for the poor verbal short-term storage capacity observed in AD. [less ▲]

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See detailPréface de : La dévalaison des poissons dans la Meuse moyenne belge
Philippart, Jean-Claude ULg; Poncin, Pascal ULg

in Sonny, Damien (Ed.) La dévalaison des poissons dans la Meuse moyenne belge (2009)

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See detailImmigrants and Their Offspring in Europe as Political Subjects
Martiniello, Marco ULg

in Hochschild, Jennifer L.; Mollenkopf, John H. (Eds.) Bringing Outsiders In. Transatlantic Perspectives on Immigrant Political Incorporation (2009)

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See detailGazing at Gawain: Reconsidering Tournaments, Courtly Love, and the Lady Who Looks
L'Estrange, Elizabeth ULg

in Medieval Feminist Forum [= MFF] (2009), 42

Historians have long acknowledged the importance of the female spectator in actual, staged, tournaments, and literary critics have noted her intrinsic role in the tournaments of romance texts.In both ... [more ▼]

Historians have long acknowledged the importance of the female spectator in actual, staged, tournaments, and literary critics have noted her intrinsic role in the tournaments of romance texts.In both cases, she functions as an inspiration to the male knight performing on the field, and as a means of constructing his masculinity.The potential agency of this female spectator who was able to look down on male bodies from a privileged viewing position has, however, been generally overlooked by art historians.This article uses the tournament context, in which women look at men (and vice versa), as a way of moving beyond the binary oppositions such as masculine/feminine, active/passive, that have traditionally structured discussions of gender and the gaze. By looking in particular at the imagery on carved ivory objects made for women, and their relationship to contemporary literature, I will argue for a more nuanced consideration of the ways women were able to look in the Middle Ages. [less ▲]

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See detailNew combinations in the Amblystegiaceae
Vanderpoorten, Alain ULg; Hedenäs, L.

in Journal of Bryology (2009), 31

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See detailFrançois Jacqmin, auteur comique
Robert, Laurent ULg

in Textyles : Revue des Lettres Belges de Langue Française (2009), 35

Cet article propose une analyse de la notion de comique dans l'oeuvre de François Jacqmin. Il montre que l'ironie est le degré de comique que le poète peut atteindre. C'est aussi grâce à l'ironie que le ... [more ▼]

Cet article propose une analyse de la notion de comique dans l'oeuvre de François Jacqmin. Il montre que l'ironie est le degré de comique que le poète peut atteindre. C'est aussi grâce à l'ironie que le poète exprime sa conception du langage et de la poésie. [less ▲]

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See detailGuidelines for an integrated diagnostic approach of chronic lymphoproliferative disorders in the routine laboratory of haematology in Belgium.
Nollet, F.; Bakkus, M.; Meeus, P. et al

in Acta Clinica Belgica (2009), 64(6), 494-504

This paper summarizes the minimal workout of chronic lymphoproliferative disorders in a routine laboratory of haematology as recommended by a team of experienced laboratory supervisors in Belgium, taking ... [more ▼]

This paper summarizes the minimal workout of chronic lymphoproliferative disorders in a routine laboratory of haematology as recommended by a team of experienced laboratory supervisors in Belgium, taking into account the specific organisation of healthcare in Belgium, the innovations in the field of molecular analyses and related reimbursement. The starting point was essentially based upon clinical and/or haematological indications and it is emphasized that conclusions should be drawn in close dialogue with the clinician and experts in cytogenetics and histopathology. Reports made in the laboratory should be based upon an integration of cytomorphological, immunophenotypical and molecular data. These guidelines are not intended to be used as universal 'diagnostic pathways', but should be useful in developing local diagnostic pathways. It is well understood that this consensus, being valid anno 2009, may rapidly change with new technologies being introduced and new targets discovered. [less ▲]

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See detailGodefroid de Huy
George, Philippe ULg

in Dictionnaire d’Histoire de l’art du Moyen Age occidental (2009)

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See detailEvaluation of the long-term barrier effect of commercial resorbable guided tissue regenerative membranes : an in vitro study using human gingival fibroblasts
Grenade, Charlotte ULg; Borget, Pascal; Moniotte, Nicolas et al

Poster (2009)

Introduction The first part of the study devoted to guided tissue regenerative membranes was focused on a better understanding of the physicochemical and mechanical properties of commercial materials. The ... [more ▼]

Introduction The first part of the study devoted to guided tissue regenerative membranes was focused on a better understanding of the physicochemical and mechanical properties of commercial materials. The second objective of our study was to develop an in vitro device able to measure the long-term barrier effect of resorbable membranes. After the development of this new device, experiments were realized to characterize the long-term behaviour of commercially membranes with human gingival fibroblasts (HGF). Materials and methods The use of human gingival fibroblastic cells was chosen to get closer to biological conditions. Some gingival explants were removed in young and non-smoking healthy patients. From these explants, fibroblastic cells were isolated and cultivated. These cells will be able to be used between the third and the sixth passage. Resorbable membranes were chosen because they don’t require a second surgical operation. There are made of polyesters or collagen. A system based on inserts was developed in order to follow the degradation of membranes and the migration of cells across the material. The membrane was cut into 8 mm diameter punches and set in the bottom of the system. Once the whole was put together, it is laced into a 12 wells plate culture. First, the plates were put in an incubator at 37°C, during times ranging from 24 hours to several months. The barrier effect was then measured to reflect the gradual increase of permeability of each membrane. For this purpose, HGF were seeded on the different samples. The top of the bottle and the bottom of the well were then filled with culture medium. Non degradable synthetic Bioflex membranes were chosen as control samples which don't let pass cells (porosity : 0,4 µm). After 48 hours of incubation in the presence of cells, pictures of cells on membranes and in the bottom of wells were taken with an optic microscope. Viability tests (MTS) were then realized on membranes to evaluate cells proliferation and in the bottom of wells to measure barrier effect. Finally, the morphology of cells on selected membranes was characterized by Scanning Electron Microscopy. Conclusion Proliferation results correspond to data published by several authors. Furthermore, the barrier effect times found in the present study are similar to barrier effect times demonstrated in in vivo studies and announced by manufacturers. In conclusion, the finalized system is adapted to the analysis of long-term barrier effect of commercial GTR membranes. This system will be tested with synthetic bioresorbable membranes made of copolymers. [less ▲]

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See detailCross-reactive T cell responses in HIV CRF01_AE and B'-infected intravenous drug users: implications for superinfection and vaccines.
Promadej-Lanier, Nattawan; Thielen, Caroline ULg; Hu, Dale J et al

in AIDS Research and Human Retroviruses (2009), 25(1), 73-81

Abstract We previously observed limited cross-reactive T cell responses in two HIV-1-superinfected injection drug users (IDUs) before superinfection [Ramos A, et al.: J Virol 2002;76(15):7444-7452]. To ... [more ▼]

Abstract We previously observed limited cross-reactive T cell responses in two HIV-1-superinfected injection drug users (IDUs) before superinfection [Ramos A, et al.: J Virol 2002;76(15):7444-7452]. To elucidate the role of such responses in superinfection we examined cross-reactive T cell responses in IDUs infected with a single HIV-1 subtype. In this study, IFN-gamma ELISPOT assays were performed using recombinant vaccinia constructs and peripheral blood mononuclear cells (PBMCs) from 43 IDUs singly infected with CRF01_AE or B' from the same cohort as the superinfected IDUs. PBMCs were from time points corresponding to pre- (early) or post- (late) superinfection in the superinfected IDUs. We observed that most singly infected IDUs had cross-reactivity in samples from early (84% of CRF01_AE and 78% of B'-infected IDUs) and late (96% of CRF_01AE and 77% of B'-infected IDUs) time points. Frequent homologous reactivity at early (67% of CRF-01AE and 100% of B') and late (84% of CRF01_AE-infected and 100% of B'-infected IDUs) time points was also observed. Cross-reactive responses were predominantly to Pol and were broader and higher in CRF01_AE than in B'-infected IDUs (medians of 825 vs. 90 and 585 vs. 60 spot-forming units/10(6) PBMCs at early and late time points, respectively). Our results show that cross-reactive responses were more prevalent with greater height and breadth in singly infected IDUs than previously observed in corresponding collection time points of superinfected IDU. Thus, low or absent cross-reactivity may have contributed to the previously observed superinfections. These data are relevant for understanding superinfection and improving vaccine design. [less ▲]

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See detailFondements de gestion financière: manuel et applications
Corhay, Albert ULg; Mbangala, Mapapa ULg

Book published by Les Editions de l'Université de Liège - 4ème édition, revue et corrigée (2009)

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See detailRelaxation of strained pseudomorphic SixGe1-x layers on He-implanted Si/δ-Si:C/Si(100) substrates
Buca, D.; Minamisawa, R. A.; Trinkaus, H. et al

in Applied Physics Letters (2009), 95

In this letter we present a method to increase the efficiency of SiGe layer relaxation by He+ ion implantation and annealing. Preferential nucleation of He platelets along a 􏰀-impurity layer grown in the ... [more ▼]

In this letter we present a method to increase the efficiency of SiGe layer relaxation by He+ ion implantation and annealing. Preferential nucleation of He platelets along a 􏰀-impurity layer grown in the Si substrate below the SiGe layer results in planar localization and homogenization of dislocation loop sources inducing a more uniform distribution of misfit dislocations. We demonstrate this for a thin Si:C layer grown by reduced pressure chemical vapor deposition. The optimization of the conditions for efficient relaxation and layer quality is studied with respect to the position of the Si:C layer and the process parameters. Relaxation degrees up to 85% are obtained for Si0.77Ge0.23 layers. [less ▲]

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See detailLa tutelle sur les marchés publics en Région wallonne
Durviaux, Ann-Lawrence ULg

Conference given outside the academic context (2009)

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See detailSujets obèses sans anomalies métaboliques
Esser, Nathalie; Scheen, André ULg

in Revue Médicale de Liège (2009), 64(3), 148-157

Obesity, especially abdominal obesity, is the main risk factor of metabolic syndrome. However, there are obviously non obese individuals who are metabolically abnormal and therefore exposed to an ... [more ▼]

Obesity, especially abdominal obesity, is the main risk factor of metabolic syndrome. However, there are obviously non obese individuals who are metabolically abnormal and therefore exposed to an increased risk of cardiovascular complications. Unfortunately, those persons fail to be detected because of a falsely reassuring body weight. The present paper aims at better understanding the etiopathogenesis and pathophysiology of this particular phenotype, at evaluating its potential clinical consequences and at describing the main principles of its therapeutic management. [less ▲]

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See detailFederal public administration reform in Belgium: new public management under deconstruction
Joris, Geoffrey ULg; de Visscher, Christian; Montuelle, Caroline

in actes du colloques de l'AFSP (2009)

Since the 1980s we assist at a co-evolutionary redefinition of social structures that its permanence contributes to legitimate it. In this perspective, the particularities of each modernities are put in ... [more ▼]

Since the 1980s we assist at a co-evolutionary redefinition of social structures that its permanence contributes to legitimate it. In this perspective, the particularities of each modernities are put in an explicit perspective and raise question because they have lost their own evidence.4 While industrial modernity is characterized by a discourse on stability, radical modernity is characterized by an information overload, an hyper-complexity, the emergence of a multidimensional uncertainty reinforced by the mergence of a multidimensional value configuration and social mobility.5 In the field of public administration, all these elements converge towards the need to construct some form of post-bureaucratic or reflexive public civil service structured through flexible and open management instruments [less ▲]

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See detailLa vignette thérapeutique de l'étudiant. La maladie de Parkinson debutante
DELVAUX, Valérie ULg; MOONEN, Gustave ULg; Garraux, Gaëtan ULg

in Revue Médicale de Liège (2009), 64(4), 228-32

We present a discussion on the treatment options in the case of a patient seen at the outpatient abnormal movement clinic for a resting tremor of both hands. Signs and symptoms of the parkinsonian ... [more ▼]

We present a discussion on the treatment options in the case of a patient seen at the outpatient abnormal movement clinic for a resting tremor of both hands. Signs and symptoms of the parkinsonian syndrome are summarized as well as the current treatment options of early Parkinson's disease. [less ▲]

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See detailMathematical modeling of bone regeneration during fracture healing
Geris, Liesbet ULg; Vander Sloten, Hans; Van Oosterwyck, Hans

in proceedings of the National Conference on Theoretical and Applied Mechanics (2009)

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