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See detailDe l’inefficacité des murs
Brunet, Sébastien ULg

Article for general public (2009)

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See detailLa variabilité du facteur de graduation utilisé dans la méthode d’estimation de la dimension fractale des mosaïques paysagères
Bamba, I; Iyongo, L; Imre, A et al

in Annales des Instituts Supérieurs d’Etudes Agronomiques de Bengamisa (2009), 4

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See detailDroits culturels et matières culturelles
Behrendt, Christian ULg

in Verdussen, Marc (Ed.) Les droits culturels et sociaux des plus défavorisés (2009)

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See detailMucosal Gene Expression of Antimicrobial Peptides in Inflammatory Bowel Disease Before and After First Infliximab Treatment
Arijs, I.; De Hertogh, G.; Lemaire, K. et al

in PLoS ONE (2009), 4(11), 7984

Background: Antimicrobial peptides (AMPs) protect the host intestinal mucosa against microorganisms. Abnormal expression of defensins was shown in inflammatory bowel disease (IBD), but it is not clear ... [more ▼]

Background: Antimicrobial peptides (AMPs) protect the host intestinal mucosa against microorganisms. Abnormal expression of defensins was shown in inflammatory bowel disease (IBD), but it is not clear whether this is a primary defect. We investigated the impact of anti-inflammatory therapy with infliximab on the mucosal gene expression of AMPs in IBD. Methodology/Principal Findings: Mucosal gene expression of 81 AMPs was assessed in 61 IBD patients before and 4-6 weeks after their first infliximab infusion and in 12 control patients, using Affymetrix arrays. Quantitative real-time reverse-transcription PCR and immunohistochemistry were used to confirm microarray data. The dysregulation of many AMPs in colonic IBD in comparison with control colons was widely restored by infliximab therapy, and only DEFB1 expression remained significantly decreased after therapy in the colonic mucosa of IBD responders to infliximab. In ileal Crohn's disease (CD), expression of two neuropeptides with antimicrobial activity, PYY and CHGB, was significantly decreased before therapy compared to control ileums, and ileal PYY expression remained significantly decreased after therapy in CD responders. Expression of the downregulated AMPs before and after treatment (DEFB1 and PYY) correlated with villin 1 expression, a gut epithelial cell marker, indicating that the decrease is a consequence of epithelial damage. Conclusions/Significance: Our study shows that the dysregulation of AMPs in IBD mucosa is the consequence of inflammation, but may be responsible for perpetuation of inflammation due to ineffective clearance of microorganisms. [less ▲]

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See detailGJA1 mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype.
Paznekas, William A; Karczeski, Barbara; Vermeer, Sascha et al

in Human Mutation (2009), 30(5), 724-33

The predominantly autosomal dominant disorder, oculodentodigital dysplasia (ODDD) has high penetrance with intra- and interfamilial phenotypic variability. Abnormalities observed in ODDD affect the eye ... [more ▼]

The predominantly autosomal dominant disorder, oculodentodigital dysplasia (ODDD) has high penetrance with intra- and interfamilial phenotypic variability. Abnormalities observed in ODDD affect the eye, dentition, and digits of the hands and feet. Patients present with a characteristic facial appearance, narrow nose, and hypoplastic alae nasi. Neurological problems, including dysarthria, neurogenic bladder disturbances, spastic paraparesis, ataxia, anterior tibial muscle weakness, and seizures, are known to occur as well as conductive hearing loss, cardiac defects, and anomalies of the skin, hair, and nails. In 2003, our analysis of 17 ODDD families revealed that each had a different mutation within the human gap junction alpha 1 (GJA1) gene which encodes the protein connexin 43 (Cx43). Since then at least 17 publications have identified an additional 26 GJA1 mutations and in this study, we present 28 new cases with 18 novel GJA1 mutations. We include tables summarizing the 62 known GJA1 nucleotide changes leading to Cx43 protein alterations and the phenotypic information available on 177 affected individuals from 54 genotyped families. Mutations resulting in ODDD occur in each of the nine domains of the Cx43 protein, and we review our functional experiments and those in the literature, examining the effects of 13 different Cx43 mutations upon gap junction activity. [less ▲]

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See detailLoss-of-function mutations in ATP6V0A2 impair vesicular trafficking, tropoelastin secretion and cell survival.
Hucthagowder, Vishwanathan; Morava, Eva; Kornak, Uwe et al

in Human Molecular Genetics (2009), 18(12), 2149-65

Autosomal recessive cutis laxa type 2 (ARCL2), a syndrome of growth and developmental delay and redundant, inelastic skin, is caused by mutations in the a2 subunit of the vesicular ATPase H+-pump ... [more ▼]

Autosomal recessive cutis laxa type 2 (ARCL2), a syndrome of growth and developmental delay and redundant, inelastic skin, is caused by mutations in the a2 subunit of the vesicular ATPase H+-pump (ATP6V0A2). The goal of this study was to define the disease mechanisms that lead to connective tissue lesions in ARCL2. In a new cohort of 17 patients, DNA sequencing of ATP6V0A2 detected either homozygous or compound heterozygous mutations. Considerable allelic and phenotypic heterogeneity was observed, with a missense mutation of a moderately conserved residue p.P87L leading to unusually mild disease. Abnormal N- and/or mucin type O-glycosylation was observed in all patients tested. Premature stop codon mutations led to decreased ATP6V0A2 mRNA levels by destabilizing the mutant mRNA via the nonsense-mediated decay pathway. Loss of ATP6V0A2 either by siRNA knockdown or in ARCL2 cells resulted in distended Golgi cisternae, accumulation of abnormal lysosomes and multivesicular bodies. Immunostaining of ARCL2 cells showed the accumulation of tropoelastin (TE) in the Golgi and in large, abnormal intracellular and extracellular aggregates. Pulse-chase studies confirmed impaired secretion and increased intracellular retention of TE, and insoluble elastin assays showed significantly reduced extracellular deposition of mature elastin. Fibrillin-1 microfibril assembly and secreted lysyl oxidase activity were normal in ARCL2 cells. TUNEL staining demonstrated increased rates of apoptosis in ARCL2 cell cultures. We conclude that loss-of-function mutations in ATP6V0A2 lead to TE aggregation in the Golgi, impaired clearance of TE aggregates and increased apoptosis of elastogenic cells. [less ▲]

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See detailDynamic holographic interferometry development for dilatometry measurement of composites under vacuum-thermal conditions
Thizy, Cédric ULg; Barbier, Christian ULg; Tychon, Isabelle ULg et al

in Dirckx, J.; Buytaert, J. (Eds.) Proceedings of the 4th International Conference on Optical Measurement and Techniques for Systems & Structures (OPTIMESS 2009) (2009)

The Centre Spatial de Liège develops since 1993 holographic interferometry techniques and instruments based on photorefractive crystals for high resolution measurement of structures deformation, mainly ... [more ▼]

The Centre Spatial de Liège develops since 1993 holographic interferometry techniques and instruments based on photorefractive crystals for high resolution measurement of structures deformation, mainly for aerospace applications. In this paper we present the early results of development of a holographic technique and facility for deformation and expansion measurement of aerospace composites components. Here the holographic technique consists in using several illumination beams for retrieving different components of the displacement vector. In our case the components and structures to be measured in the future will undergo temperatures excursions up to 150°C typically. Since holographic techniques are sensitive to air turbulences, it is necessary to place the samples in a vacuum chamber. We will present some early examples of measurements with this facility, obtained for temperatures excursions ranged between ambient and 29°C as first steps before going further to higher temperatures excursions. [less ▲]

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See detailContamination du marsouin commun (Phocoena phocoena) de la Mer du Nord par des perturbateurs endocriniens persistants
Didimo Imazaki, Pedro Henrique ULg

Master's dissertation (2009)

Endocrine disrupters are molecules able to interfere with the endocrine system and are largely spread in the environment. The evaluation of the estrogenic activity of some of these substances by reporter ... [more ▼]

Endocrine disrupters are molecules able to interfere with the endocrine system and are largely spread in the environment. The evaluation of the estrogenic activity of some of these substances by reporter gene assays was the first aim of this paper. The substances chosen are also persistent organic pollutants (POP), which are capable to bioaccumulate in several organisms. Then, the occurrence of these substances was evaluated in the blubber tissue of North Sea harbour porpoises (Phocoena phocoena). Harbour porpoises are good indicators of the environmental contamination and therefore of seafood by POP. These POP were quantified by GC-MS and also by reporter gene assays. For the achievement of these aims, different analytical methods were developed. The following raking is proposed for the studied substances, according to their estrogenic activity: o,p’-DDT > o,p’-DDD > β-HCH > p,p’-DDT > p,p’-DDD > p,p’-DDE > δ-HCH > PCB 138 > γ-HCH > α-HCH > PCB 153 > HCB > PCB 180. None of them presented anti-estrogenic activity. The analysed samples presented high levels of POP, sometimes associated with estrogenic activity, confirming the occurrence of endocrine disruptors in these animals. [less ▲]

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See detailPsychostatistique descriptive et inférentielle Partim 2 - Exercices
Quertemont, Etienne ULg

Learning material (2009)

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See detailMatisse
Lopez, B.; Lagarde, S.; Wolf, S. et al

in Moorwood, 1 (Ed.) Science with the VLT in the ELT Era (2009)

MATISSE is foreseen as a mid-infrared spectro-interferometer combining the beams of up to four UTs/ATs of the Very Large Telescope Interferometer (VLTI). MATISSE will measure closure phase relations and ... [more ▼]

MATISSE is foreseen as a mid-infrared spectro-interferometer combining the beams of up to four UTs/ATs of the Very Large Telescope Interferometer (VLTI). MATISSE will measure closure phase relations and thus offer an efficient capability for image reconstruction in the L, M and N bands of the mid-infrared domain. [less ▲]

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See detailDiem Werner, Ein arabisches Rechtsgutachten zum Eherecht aus dem 11.-12. Jahrhundert aus der Heidelberger Papyrussammlung.
Bauden, Frédéric ULg

in Bulletin Critique des Annales Islamologiques (2009), 25

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See detailPituitary adenomas in young patients : when should we consider a genetic predisposition ?
Jaffrain-Rea, M. L.; Tichomirova, M.; Daly, A. F. et al

in Expert Review of Endocrinology & Metabolism (2009), 4(6), 529-531

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See detailTwo new foliicolous species of Enterographa (Roccellaceae) from Kenya
Yeshitela, Kumelachew; Fischer, Eberhard; Killmann, Dorothee et al

in Lichenologist (2009), 41

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See detailExploring New Achievements in olefin metathesis catalysts. Part 1 - Highlights on N-heterocyclic carbene ruthenium complexes
Dragutan, Valerian; Dragutan, Ileana; Delaude, Lionel ULg et al

in Chimica Oggi = Chemistry Today (2009), 27(3), 9-12

Most important advances in ruthenium catalysts for olefin metathesis achieved during the last 4 years are briefly reviewed. The first part of the survey focuses on new catalytic precursors endowed with ... [more ▼]

Most important advances in ruthenium catalysts for olefin metathesis achieved during the last 4 years are briefly reviewed. The first part of the survey focuses on new catalytic precursors endowed with inventive N-heterocyclic carbene ligands which have proved highly proficient in a diversity of applications based on metathesis reactions. Part two extends the progress in other types of Ru initiators. [less ▲]

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See detailDesign of treatment strategies for an atrophic nonunion case in fracture healing
Geris, Liesbet ULg; Vander Sloten, Jos; Van Oosterwyck, Hans

in proceedings of the IVth International Conference on Computational Bioengineering (2009)

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See detailUn outil d'aide à la décision pour la gestion des chablis en Région wallonne
Riguelle, Simon ULg; Hebert, Jacques ULg; Jourez, Benoît ULg

in Innovations Agronomiques (2009), (6), 113-123

In order to efficiently manage post-storm damages, we developed a computer software that would be used as a decision support system by the public authorities to make the best decisions as soon as possible ... [more ▼]

In order to efficiently manage post-storm damages, we developed a computer software that would be used as a decision support system by the public authorities to make the best decisions as soon as possible after the storm, as well by showing an overview of the present situation as by comparing efficiency of several prospective simulations. The model was built on the basis of previous windthrow events in Europe and its parameters were defined after a full literature review. The system dynamics approach was used to simulate the complex scheme composed by post-storm management operations (inventory, selling, harvesting, transport and transformation). Thirty parameters can be modified by the operator to simulate the crisis situation. The main entry system is the amount of damage, which can be estimated in a very short time (3 days) by using the regional forest inventory network. The first results showed a great potential to predict evolution of a windthrow crisis and the bottlenecks which have to be solved to improve post-storm management. Of course, a validation in real conditions should confirm tool efficiency and possibility to extend its scale. [less ▲]

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See detailAnalysis of perforated magnetic shields for electric power applications
Sergeant, Peter; V Sabariego, Ruth ULg; Crevecoeur, Guillaume et al

in IET Electric Power Applications (2009), 3(2), 123-132

The shielding performance of perforated magnetic shields for electric power applications is described. The shielding of an axisymmetric induction heating device is studied as a function of frequency ... [more ▼]

The shielding performance of perforated magnetic shields for electric power applications is described. The shielding of an axisymmetric induction heating device is studied as a function of frequency, number of perforations and dimensions of the perforations. From the numerical point of view, the perforations cause the numerical model to be 3D. A numerical optimisation is carried out to find the optimal geometry with respect to the shielding factor and the volume of the shield. For the optimisation, two approaches are presented. The first approach is fast and easy-to-implement, but has limited accuracy. It uses a classical 2D axisymmetric model where the perforations are approximated by ‘axisymmetric air gaps’ resulting in a segmented shield. It is shown how to modify the 2D model to obtain results that are similar to the ones of a 3D model. The second approach is more accurate although quite fast, but more difficult to implement. It combines a 3D thin- shell finite element model with the unmodified 2D model in a space mapping optimisation algorithm. The validation of both models is based on experimental work for an unperforated shield and for the optimised perforated shield. [less ▲]

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