References of "2009"
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See detailLes linguistes et leurs graphiques. Introduction
Badir, Sémir ULg

in Cahiers Parisiens = Parisian Notebooks (2009), 5

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See detailLa tutelle sur les marchés publics en Région wallonne
Durviaux, Ann-Lawrence ULg

Conference given outside the academic context (2009)

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See detailGJA1 mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype.
Paznekas, William A; Karczeski, Barbara; Vermeer, Sascha et al

in Human Mutation (2009), 30(5), 724-33

The predominantly autosomal dominant disorder, oculodentodigital dysplasia (ODDD) has high penetrance with intra- and interfamilial phenotypic variability. Abnormalities observed in ODDD affect the eye ... [more ▼]

The predominantly autosomal dominant disorder, oculodentodigital dysplasia (ODDD) has high penetrance with intra- and interfamilial phenotypic variability. Abnormalities observed in ODDD affect the eye, dentition, and digits of the hands and feet. Patients present with a characteristic facial appearance, narrow nose, and hypoplastic alae nasi. Neurological problems, including dysarthria, neurogenic bladder disturbances, spastic paraparesis, ataxia, anterior tibial muscle weakness, and seizures, are known to occur as well as conductive hearing loss, cardiac defects, and anomalies of the skin, hair, and nails. In 2003, our analysis of 17 ODDD families revealed that each had a different mutation within the human gap junction alpha 1 (GJA1) gene which encodes the protein connexin 43 (Cx43). Since then at least 17 publications have identified an additional 26 GJA1 mutations and in this study, we present 28 new cases with 18 novel GJA1 mutations. We include tables summarizing the 62 known GJA1 nucleotide changes leading to Cx43 protein alterations and the phenotypic information available on 177 affected individuals from 54 genotyped families. Mutations resulting in ODDD occur in each of the nine domains of the Cx43 protein, and we review our functional experiments and those in the literature, examining the effects of 13 different Cx43 mutations upon gap junction activity. [less ▲]

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See detailLoss-of-function mutations in ATP6V0A2 impair vesicular trafficking, tropoelastin secretion and cell survival.
Hucthagowder, Vishwanathan; Morava, Eva; Kornak, Uwe et al

in Human Molecular Genetics (2009), 18(12), 2149-65

Autosomal recessive cutis laxa type 2 (ARCL2), a syndrome of growth and developmental delay and redundant, inelastic skin, is caused by mutations in the a2 subunit of the vesicular ATPase H+-pump ... [more ▼]

Autosomal recessive cutis laxa type 2 (ARCL2), a syndrome of growth and developmental delay and redundant, inelastic skin, is caused by mutations in the a2 subunit of the vesicular ATPase H+-pump (ATP6V0A2). The goal of this study was to define the disease mechanisms that lead to connective tissue lesions in ARCL2. In a new cohort of 17 patients, DNA sequencing of ATP6V0A2 detected either homozygous or compound heterozygous mutations. Considerable allelic and phenotypic heterogeneity was observed, with a missense mutation of a moderately conserved residue p.P87L leading to unusually mild disease. Abnormal N- and/or mucin type O-glycosylation was observed in all patients tested. Premature stop codon mutations led to decreased ATP6V0A2 mRNA levels by destabilizing the mutant mRNA via the nonsense-mediated decay pathway. Loss of ATP6V0A2 either by siRNA knockdown or in ARCL2 cells resulted in distended Golgi cisternae, accumulation of abnormal lysosomes and multivesicular bodies. Immunostaining of ARCL2 cells showed the accumulation of tropoelastin (TE) in the Golgi and in large, abnormal intracellular and extracellular aggregates. Pulse-chase studies confirmed impaired secretion and increased intracellular retention of TE, and insoluble elastin assays showed significantly reduced extracellular deposition of mature elastin. Fibrillin-1 microfibril assembly and secreted lysyl oxidase activity were normal in ARCL2 cells. TUNEL staining demonstrated increased rates of apoptosis in ARCL2 cell cultures. We conclude that loss-of-function mutations in ATP6V0A2 lead to TE aggregation in the Golgi, impaired clearance of TE aggregates and increased apoptosis of elastogenic cells. [less ▲]

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See detailGazing at Gawain: Reconsidering Tournaments, Courtly Love, and the Lady Who Looks
L'Estrange, Elizabeth ULg

in Medieval Feminist Forum [= MFF] (2009), 42

Historians have long acknowledged the importance of the female spectator in actual, staged, tournaments, and literary critics have noted her intrinsic role in the tournaments of romance texts.In both ... [more ▼]

Historians have long acknowledged the importance of the female spectator in actual, staged, tournaments, and literary critics have noted her intrinsic role in the tournaments of romance texts.In both cases, she functions as an inspiration to the male knight performing on the field, and as a means of constructing his masculinity.The potential agency of this female spectator who was able to look down on male bodies from a privileged viewing position has, however, been generally overlooked by art historians.This article uses the tournament context, in which women look at men (and vice versa), as a way of moving beyond the binary oppositions such as masculine/feminine, active/passive, that have traditionally structured discussions of gender and the gaze. By looking in particular at the imagery on carved ivory objects made for women, and their relationship to contemporary literature, I will argue for a more nuanced consideration of the ways women were able to look in the Middle Ages. [less ▲]

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See detailFondements de gestion financière: manuel et applications
Corhay, Albert ULg; Mbangala, Mapapa ULg

Book published by Les Editions de l'Université de Liège - 4ème édition, revue et corrigée (2009)

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See detailEntraînement excentrique des rotateurs d'épaule
Forthomme, Bénédicte ULg; Chague, Lucie ULg; Crielaard, Jean-Michel ULg et al

in Croisier, Jean-Louis; Codine, Philippe (Eds.) Exercice musculaire excentrique (2009)

In this study, we have investigated the influence of the installation on the dynamometer and of the mode of contraction used during a rotator cuff muscle training. 24 subjects were divided into 3 groups ... [more ▼]

In this study, we have investigated the influence of the installation on the dynamometer and of the mode of contraction used during a rotator cuff muscle training. 24 subjects were divided into 3 groups. Two groups of 8 subjects performed a training of the Internal Rotators (IR) in concentric mode (60°/s and 240°/s) and of the External Rotators in eccentric mode (60°/s). The first group was trained at 45° of abduction; the second was trained at 90° of abduction. The third group did not perform any shoulder training. All patients were assessed thanks to the isokinetic device ((3) x 60°/s concentric – (5) x 240°/s concentric – (4) x 60°/s eccentric) before and after training. Only the group trained at 45° of abduction increased the isokinetic maximal peak torque (+ p) in concentric mode during the second isokinetic assessment. No subject showed improvement through the eccentric exercise. They also improved the throw of the ball (+ 8.5 %). Possible feeling of discomfort and signs of subacromial conflict explained that no progression was recorded after training at 90° of abduction. Likewise, the eccentric mode would major the inhibition limiting the strength increase. Even if 90° of abduction seems more specific for assessment, 45° of abduction is more suitable for training. [less ▲]

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See detailConcept d'équilibre agonistes / antagonistes de l'épaule
Forthomme, Bénédicte ULg; Crielaard, Jean-Michel ULg; Croisier, Jean-Louis ULg

in Croisier, Jean-Louis; Codine, Philippe (Eds.) Exercice musculaire excentrique (2009)

Besides the concentric classical ratios, the eccentric isokinetic assessment of the muscle shoulder allows us to build some specific ratios. The mixed ratio combines the eccentric maximal contraction of ... [more ▼]

Besides the concentric classical ratios, the eccentric isokinetic assessment of the muscle shoulder allows us to build some specific ratios. The mixed ratio combines the eccentric maximal contraction of the external rotators (ER) and the concentric maximal strength of the internal rotators (IR). The mixed ratio is frequently decreased among overhead athletes. This imbalance could rise to shoulder tendinopathy, but seemed to be linked with field performance. The functional ratio corresponds to the balance between the ER in concentric mode and the IR in eccentric contraction. The unstable shoulder shows a trend to lower functional ratios, highlighting the weakness of the eccentric IR in that pathology. [less ▲]

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See detailNew combinations in the Amblystegiaceae
Vanderpoorten, Alain ULg; Hedenäs, L.

in Journal of Bryology (2009), 31

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See detailComment investiguer la contre-performance d’origine médicale : de la clinique au laboratoire
Richard, Eric; Pitel, P. H.; Fortier, G. et al

in 35ème Journée de la Recherche équine (2009)

Clinical affections of the locomotor and respiratory systems are the two main causes of poor performance in sport horses. Nevertheless, each subclinical affection of any system implicated in the oxygen ... [more ▼]

Clinical affections of the locomotor and respiratory systems are the two main causes of poor performance in sport horses. Nevertheless, each subclinical affection of any system implicated in the oxygen system (respiratory, cardiovascular, blood, muscular and metabolic) may also become a limiting factor concerning the athletic capacities of the horse. A systematic medical examination of the horse, combining ail the clinical and laboratory exams, is thus necessary in order to establish a precise and comprehensive diagnosis regarding the different affections. The objectives of this communication are therefore to present the different methods currently available for the practitioner as well as the techniques recently developed for horses. The complementarity of the different clinical and laboratory exams, as well as the ideal moment for performing each test are clarified in order to accurately determine the different causes of poor performance as well as their functional repercussions [less ▲]

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See detailUse of chips and cassava leaves in finishing guinea (Numida meleagris, L): animal performance, costs of production, Aspect of the carcass and meat quality
Dahouda, M.; Toleba, S. S.; Youssao, A. K. I. et al

in Annales de Médecine Vétérinaire (2009), 153(2), 82-87

The effect of feed containing cassava leafs and peels was assessed on 126 local guinea fowls animal performance, production costs and meat quality over a period of 28 weeks in humid tropical climate of ... [more ▼]

The effect of feed containing cassava leafs and peels was assessed on 126 local guinea fowls animal performance, production costs and meat quality over a period of 28 weeks in humid tropical climate of the South Benin. After 12 weeks of classical feeding, animals were randomly allotted in three groups of 42 for the finishing period: the group 1 received a control diet while, in group 2, 8% and 35 % of cassava leafs and cossets were respectively incorporated, vs. 6 % and 25 % in group 3. At the end of the trial, eighteen guinea fowls per group were slaughtered in order to determine characteristics of the carcass and meat quality. Individual daily feed intake was higher in the control group than in the groups 2 and 3. Animals from control group shown higher growth rate (5.0 g/d) (P<0.05) than in groups 2 and 3. Consequently, feed conversion ratios were similar in the three groups with values of 7.5, 6.7 and 6.9, in groups 1, 2 and 3, respectively. At the end of the trial, animals in control group were heavier than those in groups 2 and 3 (P<0.05). No negative influence of cassava cossets and leaf meals was observed on carcass quality in the experimental diets. Feed costs per kg live weight were reduced by 24.6 and 21.0% in groups 2 and 3, respectively, when compared to control group. Guinea fowl production appears thus more profitable with feed containing cassava leaves and cossets. Consequently, these ingredients could be alternative sources of energy and protein, with emphasis during the finishing period. [less ▲]

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See detailNew karyotypic data for Asian rodents (Rodentia, Muridae) with the first report of B-chromosomes in the genus Mus
Badenhorst, Daleen; Herbreteau, Vincent; Chaval, Yannick et al

in Journal of Zoology (2009), 279(1), 44-56

Karyotypes of 18 rodent species collected in various localities in Thailand were analysed as part of an epidemiological survey of the region using conventional cytogenetic techniques. The aim was to re ... [more ▼]

Karyotypes of 18 rodent species collected in various localities in Thailand were analysed as part of an epidemiological survey of the region using conventional cytogenetic techniques. The aim was to re-assess the reliability of karyotype-based diagnoses of Thai rodents using an updated taxonomic framework. The species examined include Menetes berdmorei (Sciuridae), Mus caroli, Mus cervicolor and Mus cookii, Hapalomys delacouri, Chiropodomys gliroides, as well as several representatives of most of the lineages of the Rattini tribe, that is Rattus exulans, Rattus losea, Rattus tanezumi, Leopoldamys edwardsi, Leopoldamys neilli, Maxomys surifer, Niviventer fulvescens, Berylmys berdmorei, Berylmys bowersi, Bandicota indica and Bandicota savilei (Muridae). The first descriptions of G- and/or C-banding karyotypes are provided for several of these, that is, B. savilei, L. edwardsi, M. surifer, B. berdmorei, B. bowersi, N. fulvescens and H. delacouri. Although largely in agreement with available data, our findings on chromosome morphology differ slightly from those published for L. edwardsi, M. surifer, B. savilei and the two Berylmys species, B. berdmorei and B. bowersi. In addition, we document the novel finding of B-chromosomes in the genera Berylmys, Bandicota and the emblematic Mus. Importantly, few species-specific chromosomal characteristic could be identified within most of the genera investigated in our study and, in contrast to previous claims, the usefulness of karyotypes for diagnosing these Asian murid species appears to be limited. [less ▲]

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See detailThe usefulness of operant conditioning procedures to assess long-lasting deficits following transient focal ischemia in mice.
Ferrara, André ULg; El Bejaoui, Sophie; Seyen, Sandrine ULg et al

in Behavioural Brain Research (2009), 205(2), 525-34

In this study, we examined a number of short and long-term sensorimotor, behavioural and cognitive consequences of an experimental ischemia induced by a 60-min right middle cerebral artery occlusion (MCAO ... [more ▼]

In this study, we examined a number of short and long-term sensorimotor, behavioural and cognitive consequences of an experimental ischemia induced by a 60-min right middle cerebral artery occlusion (MCAO) in 129S2 mice. During 14 days after surgery, a classical sensorimotor assessment was conducted using hanging wire test, negative geotaxis test, grip strength test, accelerated rotarod test and locomotor activity-meter. In order to provide a technique for the assessment of more resistant consequences of ischemia on fine psychomotor control, the peak procedure (a modified version of the operant fixed-interval schedule of reinforcement) was used. This procedure also helped to objectify temporal perception in mice five weeks following surgery. On several sensorimotor tests, ischemic mice showed some degree of impairment which rapidly tended to improve after stroke, a profile of results substantially consistent with previous studies. Five weeks post-surgery, ischemic mice tested with the peak procedure exhibited a moderate but yet significant temporal regulation impairment along with a reduced response rate compared to control mice. The present results suggest that the peak procedure and other derived operant schedules of reinforcement may provide useful and sensitive tools for the long-term assessment of both behavioural and cognitive aspects of the consequences of an experimental ischemia. [less ▲]

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See detailVidéo : la gestion de la reproduction bovine. Deuxième partie.
Hanzen, Christian ULg

Diverse speeche and writing (2009)

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See detailMucosal Gene Expression of Antimicrobial Peptides in Inflammatory Bowel Disease Before and After First Infliximab Treatment
Arijs, I.; De Hertogh, G.; Lemaire, K. et al

in PLoS ONE (2009), 4(11), 7984

Background: Antimicrobial peptides (AMPs) protect the host intestinal mucosa against microorganisms. Abnormal expression of defensins was shown in inflammatory bowel disease (IBD), but it is not clear ... [more ▼]

Background: Antimicrobial peptides (AMPs) protect the host intestinal mucosa against microorganisms. Abnormal expression of defensins was shown in inflammatory bowel disease (IBD), but it is not clear whether this is a primary defect. We investigated the impact of anti-inflammatory therapy with infliximab on the mucosal gene expression of AMPs in IBD. Methodology/Principal Findings: Mucosal gene expression of 81 AMPs was assessed in 61 IBD patients before and 4-6 weeks after their first infliximab infusion and in 12 control patients, using Affymetrix arrays. Quantitative real-time reverse-transcription PCR and immunohistochemistry were used to confirm microarray data. The dysregulation of many AMPs in colonic IBD in comparison with control colons was widely restored by infliximab therapy, and only DEFB1 expression remained significantly decreased after therapy in the colonic mucosa of IBD responders to infliximab. In ileal Crohn's disease (CD), expression of two neuropeptides with antimicrobial activity, PYY and CHGB, was significantly decreased before therapy compared to control ileums, and ileal PYY expression remained significantly decreased after therapy in CD responders. Expression of the downregulated AMPs before and after treatment (DEFB1 and PYY) correlated with villin 1 expression, a gut epithelial cell marker, indicating that the decrease is a consequence of epithelial damage. Conclusions/Significance: Our study shows that the dysregulation of AMPs in IBD mucosa is the consequence of inflammation, but may be responsible for perpetuation of inflammation due to ineffective clearance of microorganisms. [less ▲]

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See detailGilles Hayne, Missa pro defunctis/Officium defunctorum/Sequens post missam ad sepeliendum [Manuscrit des cérémonies funèbres en l'honneur de Marie de Médicis], 7 vol., Liège, XVIIe s.
Corswarem, Emilie ULg

in Bruyère, Paul; Marchandisse, Alain (Eds.) Le florilège du livre en principauté de Liège (2009)

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See detailMuscular strength, functional performances and injury risk in professional and junior elite soccer players.
Lehance, Cédric ULg; Binet, J.; Bury, Thierry ULg et al

in Scandinavian Journal of Medicine & Science in Sports (2009), 19(2), 243-51

Muscle strength and anaerobic power of the lower extremities are neuromuscular variables that influence performance in many sports activities, including soccer. Despite frequent contradictions in the ... [more ▼]

Muscle strength and anaerobic power of the lower extremities are neuromuscular variables that influence performance in many sports activities, including soccer. Despite frequent contradictions in the literature, it may be assumed that muscle strength and balance play a key role in targeted acute muscle injuries. The purpose of the present study was to provide and compare pre-season muscular strength and power profiles in professional and junior elite soccer players throughout the developmental years of 15-21. One original aspect of our study was that isokinetic data were considered alongside the past history of injury in these players. Fifty-seven elite and junior elite male soccer players were assigned to three groups: PRO, n=19; U-21, n=20 and U-17, n=18. Players benefited from knee flexor and extensor isokinetic testing consisting of concentric and eccentric exercises. A context of lingering muscle disorder was defined using statistically selected cut-offs. Functional performance was evaluated throughout a squat jump and 10 m sprint. The PRO group ran faster and jumped higher than the U-17 group (P<0.05). No significant difference in isokinetic muscle strength performance was observed between the three groups when considering normalized body mass parameters. Individual isokinetic profiles enabled the identification of 32/57 (56%) subjects presenting lower limb muscular imbalance. Thirty-six out of 57 players were identified as having sustained a previous major lower limb injury. Of these 36 players, 23 still showed significant muscular imbalance (64%). New trends in rational training could focus more on the risk of imbalance and implement antagonist strengthening aimed at injury prevention. Such an intervention would benefit not only athletes recovering from injury, but also uninjured players. An interdisciplinary approach involving trainers, a physical coach, and medical staff would be of interest to consider in implementing a prevention programme. [less ▲]

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See detailSubjective evaluation of the long-term efficacy of speech therapy on dysfunctional dysphonia.
Morsomme, Dominique ULg; Faurichon de la Bardonnie, Marie; Verduyckt, Ingrid et al

in Journal of Voice (2009)

The objective of the study was to measure the subjective long-term effects of vocal therapy (more than 6 months) in 29 patients suffering from dysfunctional dysphonia. Four subjective measurements were ... [more ▼]

The objective of the study was to measure the subjective long-term effects of vocal therapy (more than 6 months) in 29 patients suffering from dysfunctional dysphonia. Four subjective measurements were used: one visual analog scale ranging from 0 (not efficient at all) to 100 (very efficient); one question "Is the speech therapy still efficient?," answered by yes or no; the GRB parameters of the GRBAS scale (evaluated by the patient); and the VHI-10. The results show that 76% of the patients consider that the vocal therapy they received is still efficient. On the vocal quality (G), roughness (R), and breathiness (B) parameters, we observe a high degree of satisfaction on the G parameter (median=77). The scores on the R and B parameters are lower (median R=12, S=5). Roughness is significantly correlated to the Grade (Spearman coefficient r=0.516, P=0.004), whereas breathiness is not (P=0.251, NS). The comparison of the results on the VHI-10 pre and post treatment shows a significant decrease in the grade of perceived handicap (medians 15 vs 11, P=0.017). The correlations between the judgment of the treatment's efficacy and the vocal quality is significant (r=0.623, P<0.001) as well as the correlation between the VHI-10 and the length of the treatment (r=0.416, P=0.035). The conclusion can be made that speech therapy plays an important role in long-term treatment of dysfunctional dysphonias. [less ▲]

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