References of "2009"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailRevisiting the role of zooplankton in pelagic ecosystems
Hecq, Jean-Henri ULg; Goffart, Anne ULg

in Journal of Marine Systems (2009), 78

Preface of the 38th International Liège Colloquium on Ocean Dynamics (Liège, Belgium, 8–12 May 2006) : Revisiting the role of zooplankton in pelagic ecosystems. Issue of JMS edited by Jean-Henri Hecq and ... [more ▼]

Preface of the 38th International Liège Colloquium on Ocean Dynamics (Liège, Belgium, 8–12 May 2006) : Revisiting the role of zooplankton in pelagic ecosystems. Issue of JMS edited by Jean-Henri Hecq and Anne Goffart. [less ▲]

Detailed reference viewed: 45 (8 ULg)
Full Text
Peer Reviewed
See detailAn 11 - Year Overview of the belgian donor and transplant statistics bsed on a consecutive yearly data follow-up and comparing two periods : 1997 to 2005 versus 2006 to 2007
Van Gelder, F.; Delbouille, Marie-Hélène ULg; Vandervennet, M. et al

in Transplantation Proceedings (2009), 41

Background. The Belgian Transplant Coordinators Section is responsible for the yearly data follow-up concerning donor and transplantation statistics in Belgium and presents herein a 10-year overview ... [more ▼]

Background. The Belgian Transplant Coordinators Section is responsible for the yearly data follow-up concerning donor and transplantation statistics in Belgium and presents herein a 10-year overview. Methods. The procurement and transplant statistics were compared between 2 periods: Period 1 (P1, 1997–2005) versus Period 2 (P2, 2006–2007). Results. The kidney and liver waiting lists (P1 vs P2) showed an overall decrease for a period of 2 consecutive years in P2; kidney ( 170 patients; 18%), and liver ( 83 patients; 34%). All other waiting lists (heart, lung, pancreas) remained stable. Mean ED further increased (P1 vs P2); 229 (P1) versus 280 (P2, 22.27%). Non–heart-beating donors were significantly ( 288%) more often procured in P2. Mean donor age was 37.9 17.8 years (P1) versus 46.5 19.9 years (P2), and mean organ yield per donor was 3.48 1.7 (P1) versus 3.38 1.8 (P2). Overall transplant activity per million inhabitants increased 21.1%. Conclusion. For 2 consecutive years, the Belgian statistics showed significantly increased donor activity with an impact on waiting list dynamics and transplantation. The mean organ yield per donor was not influenced despite an increased average age and change in reason for death. [less ▲]

Detailed reference viewed: 26 (0 ULg)
Full Text
Peer Reviewed
See detailLes coproduits européens issus du bioéthanol produit au départ de céréales ont une composition chimique variable
Piron, Fabien ULg; Bruyer, Denis; Thewis, André ULg et al

in journées de la recherche avicole (2009)

There is worldwide increasing interest in producing ethanol from grains. Currently, maize is the main grain used in fuel ethanol production (particularly in the USA). However, in Western Europe and Canada ... [more ▼]

There is worldwide increasing interest in producing ethanol from grains. Currently, maize is the main grain used in fuel ethanol production (particularly in the USA). However, in Western Europe and Canada, wheat is the main grain for ethanol plants. Barley, rye, sorghum or combinations of grains are also used. The process of ethanol production from grains generates by-products (distillers’ grains, solubles and/or gluten feed) with potential in livestock feed. Consequently, a better knowledge of chemical composition of these by-products is essential. The aim of the present study was to chemically characterise 14 batches of by-products (mainly from wheat, but also from barley and maize) purchased from some plants in Western Europe. Starch was almost completely removed by ethanol production process. Consequently, crude protein and fibre were concentrated in by-products with regard to grain value. Ratios of by-products to grain (wheat is reference) varied between 1.6 and 3.2 (protein), 1.6 and 2.7 (NDF) and 2.3 and 5.1(ADF). Furthermore, heat treatment used during the production process of dried distillers’ grains could cause destruction of important amounts of some amino acids, especially lysine (Maillard reactions). Ratios of lysine to crude protein varied among batches of byproducts and were particularly poor and unstable for distillers’ grains. In conclusion, chemical composition of European by-products of ethanol fuel produced from grains is variable. It is particularly important for wheat-based distillers’ grains. More information is needed about digestibility and availability of nutriments from these by-products. Particularly, lysine concentration and availability are probably one of the main concerns for nutritive value of by-products of ethanol fuel produced from grains. [less ▲]

Detailed reference viewed: 76 (8 ULg)
Full Text
Peer Reviewed
See detailIntegracion Numerica del Problema Viscoplastico
Andia Fages, Susana; Raichman, Silvia; Mirasso, Anibal et al

(2009)

En este trabajo se discute la integración numérica para el modelo viscoplástico de Perzyna, que conduce a una ecuación de consistencia viscoplástica no lineal, de acuerdo a un trabajo previo de Ponthot ... [more ▼]

En este trabajo se discute la integración numérica para el modelo viscoplástico de Perzyna, que conduce a una ecuación de consistencia viscoplástica no lineal, de acuerdo a un trabajo previo de Ponthot. Esta ecuación no lineal se resuelve mediante elMétodo de Newton Raphson y el algoritmo resultante se implementa en MATLAB. Los resultados obtenidos con el programa desarrollado ajustan muy bien con soluciones cerradas disponibles en la literatura para algunos casos particulares. En este trabajo además se propone una solución cerrada para el caso de sensitividad viscosa lineal (m=1) y exponente de endurecimiento viscoplástico lineal (n=1). Se estudia además la respuesta del algoritmo frente a la variación de diferentes parámetros como el coeficiente de viscosidad. El código obtenido en una etapa posterior del estudio se podrá utilizar para resolver otros problemas de interés y, además, permitirá su implmentación en un código de elementos finitos con capacidades no lineales. [less ▲]

Detailed reference viewed: 62 (3 ULg)
Full Text
Peer Reviewed
See detailDiscrepancies between creatinine-based and cystatin C-based equations in estimating prevalence of stage 3 chronic kidney disease in an elderly population.
Delanaye, Pierre ULg; Cavalier, Etienne ULg; Saint-Remy, Annie ULg et al

in Scandinavian Journal of Clinical & Laboratory Investigation (2009), 69(3), 344-9

Background . The prevalence of stage 3 chronic kidney disease (CKD) is increasing, calculated using the modification of diet in renal disease (MDRD) study equation for estimating glomerular filtration ... [more ▼]

Background . The prevalence of stage 3 chronic kidney disease (CKD) is increasing, calculated using the modification of diet in renal disease (MDRD) study equation for estimating glomerular filtration rate (GFR). Cystatin C-based equations are also being used to estimate GFR. Using creatinine-based and cystatin C-based equations, the aim of our study was to measure the difference in prevalence of stage 3 CKD in a population. Methods . CKD screening is organized in the Province of Liege, Belgium. On a voluntary basis, people aged between 45 and 75 years are invited for screening. GFR is estimated using the MDRD study equation and by the three recent cystatin C-based equations proposed by Levey's group. The Levey 1 equation is based on cystatin C only and the Levey 2 equation on cystatin C corrected for age and sex. The Levey 3 equation combines cystatin C, creatinine, age and sex. Results . The population screened comprised 754 people. Cystatin C is highly correlated with creatinine (r = 0.6196, p<0.0001). Prevalence of stage 3 CKD when GFR is estimated by the MDRD equation study is 17.2 %, which is significantly and much higher than the prevalence obtained when cystatin C-based equations are used. Indeed, prevalence is 2 %, 3.3 % and 5.8 % with the Levey 1, 2 and 3 equations, respectively. Conclusions . The prevalence of stage 3 CKD varies strongly following the method used for estimating GFR, creatinine-based or cystatin C-based equations. Such discrepancies must be confirmed and explained in additional studies using GFR measured with a reference method. [less ▲]

Detailed reference viewed: 43 (4 ULg)
See detailLe Paléolithique supérieur de la Moldavie. Essai de synthèse d'une évolution multi-culturelle
Noiret, Pierre ULg

Book published by Service de Préhistoire de l'Université de Liège (2009)

Les industries lithiques du Paléolithique supérieur en Moldavie sont fondées sur l’exploitation de roches locales et appartiennent principalement à des traditions culturelles connues en Europe ... [more ▼]

Les industries lithiques du Paléolithique supérieur en Moldavie sont fondées sur l’exploitation de roches locales et appartiennent principalement à des traditions culturelles connues en Europe (l’Aurignacien, le Gravettien, puis l’Épigravettien). Cependant, elles coexistent avec d’autres industries marquées par la présence d’outils aménagés par retouche bifaciale, dans des contextes réputés anciens (plus de 30.000 ans), mais se révélant à l’analyse mal datées et souvent peu homogènes. Ces industries appartiennent à trois ou quatre traditions culturelles supplémentaires, dont les définitions restent vagues. Après avoir fouillé les sites de Mitoc–Malu Galben (Roumanie) et de Cosăuţi (République Moldave) en compagnie de leur responsable (V. Chirica et I.A. Borziac) et avec l’aide de nos collègues de l’Université de Liège (le Prof. Marcel Otte, I. López Bayón et V. Ancion) et de l’Institut royal des Sciences naturelles de Belgique (P. Haesaerts et Fr. Damblon), nous avons entrepris l’étude comparative des données chronologiques, stratigraphiques, fauniques et matérielles (outillages lithiques et osseux, témoins esthétiques) de 21 sites pour la période comprise entre 35.000 et 10.000 ans BP. Nous avons constitué ainsi un corpus d’une cinquantaine d’ensembles archéologiques. Une lecture critique des informations publiées par les fouilleurs a permis une répartition de tous les ensembles étudiés (ou presque) dans un schéma chronostratigraphique régional bien assuré et bien daté, élargi en fin de travail à l’ensemble de l’Europe centrale et orientale. Ces ensembles appartiennent à l’Aurignacien typique (33.000-29.000 BP), au Gravettien (29.500-23.000 BP), à la Culture du Prut (27.000-26.000 BP), à l’Aurignacien tardif (vers 25.000 puis 20.000 BP), à l’Épigravettien ancien (20.000-17.000 BP) puis récent (13.500-11.000 BP). Les vestiges de débitage, les outils domestiques et les armatures liées à la chasse ont été décrits et soumis à une analyse factorielle des. Si l’analyse technologique n’a porté que sur des indications de présence/absence de caractéristiques technologiques, l’analyse typologique a pu être menée sur des données plus complètes (les pourcentages de tous les outils lithiques, dans chaque ensemble étudié), permettant de mettre en évidence les particularités et l’évolution des traditions culturelles étudiées. Les industries lithiques caractérisées par la présence de pièces bifaciales ne semblent désormais plus pouvoir être décrites en tant que plusieurs entités culturelles distinctes ; au contraire, les analyses ont montré leur relative homogénéité technologique et typologique. Il est probable qu’elles représentent une expression culturelle unique, coexistant avec les autres traditions et localisée dans une zone géographique restreinte ; cela justifie l’emploi de la dénomination de « Culture du Prut ». Cette culture est marquée par la production prédominante d’éclats, employés comme supports à l’outillage, et dans une moindre mesure de lames à partir de nucléus peu préparés et encore assez « plats », alors que dans l’Aurignacien et surtout dans le Gravettien les lames sont les supports principaux, obtenus à partir de nucléus volumétriques, bien préparés et entretenus. L’étude des restes fauniques a permis de mettre en évidence des différences marquées entre traditions culturelles : les Aurignaciens ont chassé le cheval et le bison ; les Gravettiens, le cheval et le renne, puis le bison et peut-être le mammouth. C’est après l’hiatus de 23.000-20.000 BP que l’analyse faunique est la plus significative : les Épigravettiens se sont alors véritablement spécialisés dans la chasse au renne ; dans la plupart des sites, les restes de ces animaux atteignent souvent 70 à 80 % de tous les restes identifiables, devant le cheval et  plus rarement  le bison (ou l’aurochs) et le mammouth. En outre, des petits animaux étaient piégés pour leur fourrure (lièvres, renards) et des poissons et des oiseaux complétaient l’alimentation, ainsi sans doute que des aliments végétaux. À cette spécialisation épigravettienne correspond une entité ethnique homogène, entre 20.000 et 17.000 BP. Des sites à fonction limitée existent alors, à côté de grandes installations occupées peut-être plus longtemps mais surtout plus souvent qu’auparavant. Toutes les installations sont saisonnières. Comme dans les traditions culturelles antérieures, les contacts extra-régionaux semblent limités et les roches locales continuent d’être exploitées. Des comparaisons avec l’Europe centrale et orientale ont permis de lier ce Paléolithique supérieur moldave à quelques phénomènes culturels plus larges : l’exploration par les Aurignaciens d’un territoire s’étendant jusqu’au centre de la Plaine russe et jusqu’aux contreforts septentrionaux de l’Oural (dès 33.000 BP), les origines géographiques multiples du Gravettien (vers 30.000 BP), la présence d’industries lithiques non-aurignaciennes et non-gravettiennes (à pièces bifaciales, sans doute autour de 27.000-26.000 BP), la résurgence de traits techniques d’allure « aurignacoïde » (dès 21.000 BP), et le retour massif de la tradition des outils à dos (à partir de 20.000 BP). Ainsi, les données moldaves s’inscrivent-elles logiquement dans une paléo-histoire large, à l’échelle de l’ensemble du continent. [less ▲]

Detailed reference viewed: 223 (7 ULg)
Full Text
Peer Reviewed
See detailCaractérisation paysanne de Hippopotamus amphibius Linné 1758, dans la Réserve de Biosphère de la Mare aux Hippopotames, en zone sud soudanienne du Burkina Faso
Dibloni, O. T.; Coulibaly, N. D.; Guenda, W. et al

in International Journal of Biological and Chemical Sciences (2009), 3(2), 386-397

L’étude de la caractérisation de l’hippopotame par les populations villageoises a visé à inventorier les savoirs endogènes sur l’espèce dans la Réserve de Biosphère de la Mare aux Hippopotames du Burkina ... [more ▼]

L’étude de la caractérisation de l’hippopotame par les populations villageoises a visé à inventorier les savoirs endogènes sur l’espèce dans la Réserve de Biosphère de la Mare aux Hippopotames du Burkina Faso. L’inventaire de ces savoirs a porté sur l’effectif des populations d’hippopotames, la différenciation sexuelle, le régime alimentaire, les valeurs socioéconomiques et culturelles ainsi que les dégâts dus à cette espèce. L’enquête a été conduite dans six villages de l’ethnie Bobo et a concerné un échantillon de 77 personnes. Les personnes enquêtées savent que les hippopotames sont présents dans la réserve et estiment leur effectif à environ 33 individus. A l’aide de critères morphologiques et éthologiques, les villageois opèrent une différenciation sexuelle chez ces animaux. Le régime alimentaire est connu et comprendrait selon eux une quarantaine d’espèces végétales. Outre les valeurs socioéconomiques, culturelles et touristiques que la présence des hippopotames procure, les populations savent aussi que ces animaux participent au maintien de la biodiversité et à la fertilisation de la mare pour la production de poissons. Toutefois, l’espèce serait également à l’origine de la destruction des filets de pêche, de dégâts sur les cultures céréalières et de quelques accidents mortels. [less ▲]

Detailed reference viewed: 90 (15 ULg)
Full Text
See detailSix notices décrivant des ouvrages ayant trait au voyage
Bauden, Frédéric ULg

in Bruyère, Paul; Marchandisse, Alain (Eds.) Florilège du livre en principauté de Liège du IXe au XVIIIe siècle (2009)

Notice 1: De Mandeville, Johannes. Itinerarius a terra Anglie in partes Hyerosolomitanas et in ulteriores transmarinas, editus primo in lingua gallicana a milite suo auctore, anno incarnationis Dni. 1355 ... [more ▼]

Notice 1: De Mandeville, Johannes. Itinerarius a terra Anglie in partes Hyerosolomitanas et in ulteriores transmarinas, editus primo in lingua gallicana a milite suo auctore, anno incarnationis Dni. 1355, in civitate Leodiensi, et paulo post eadem civitate translatus in hanc formam latinam. Université de Liège, ms. 354 (ff. 13-55). Copié par Goeswin de Susteren du couvent des Croisiers à Huy en 1458. Université de Liège, ms. Wittert 99 (77 ff.). XVe s. De Mandeville, Jean. Voyage, [Lyon, Nicolas Philippe et Marc Reinhart, avant 1483]. Université de Liège, cote XV C 66. In-fol. (250 x 180 mm). Caractères gothiques. 79 ff. Notice 2: Darmont, Lambert. Il Viaggio de Heirusalem de Messere Lamberto D[a]rmont Huyensis nel quale con ordine da conto de tutte le cose viste et osservate da lui in esso viaggio con piu carte di geographia di diversi paese et col ritracto de più terre pincipali. Ms. en partie autographe (?) du XVIe s. Papier filigrané. 175 ff. plus un en tête et un en queue, 270 x 160 mm., 141 p. avec dessins. Bruxelles, Bibliothèque Royale, ms. 21056. Notice 3: Voyage de la saincte cité de Hiérusalem, jointe la description des citez, villes, ports lieux et autres passages. Ensemble les cérémonies des Turcs, avec l’estat de leur empereur, ordre de sa gendarmerie, finances et succès de ses conquestes, etc. Pièça descrits par Bartélémi Georginitz (sic), Hongrois, pélérin dudit voiage, par un long temps esclave en Turquie. Le tout remis en lumière par M. Lambert Darmont Liégeois. A Liége. Par Léonard Streel Imprimeur juré. Aux dépens de Lambert de la Coste, MDC. In-4°, de 62 ff. non ch. Göttingen, Universitätsbibliothek, 8 ITIN I, 2701 ; Paris, BnF, RES-O2F-982, J-6613 (disparu) et 4-H-486 ; Paris, Mazarine, A. 14298 ; Paris, Arsenal, H. 1043. Notice 4: Des habits, mœurs, cérémonies, façons de faire anciennes et modernes du monde. Traicté non moins utile que délectable. Avec les pourtraicts des habits taillés par jean de Glen. Liégeois. Divisé –en deux parties. Partie première : des principales nations, provinces, régions et villes de l’Europe. A Liege. Chez J. de Glen, demeurant en la rue dite Gerarderie, à l’Escu d’or. 1601. In-8°, de 8 ff. lim., 218 ff. ch. (la pagination est défectueuse : les ff. 129 à 168 sont chiffrés 179 à 218) et 13 ff. de table. Avec 104 fig. sur bois. Débute par une épître adressée à Mathias d’Ans et Jacques Libert, bourgmestres de la cité de Liège, datée du 15 juin 1601. Le dernier f. de la table porte, au verso, l’approbation de Jean Chapeauille, vicaire de Liège, datée du 12 juin 1601. Université de Liège, cote R00203A : ex-libris de Bartholomé Van den Kerckhove, 1775. Un autre exemplaire sous la cote XX.74.17. Un ex. à Bruxelles, Bibliothèque Royale. Trois exemplaires à Paris, dont deux à la BnF (catalogue en ligne), un à l’Institut national d’histoire de l’art (12 Res 186). Notice 5: BOUCHER (le P. Jean). Bouquet sacré, composé des plus belles fleurs de la Terre Saincte, par le R. P. Jean Boucher, mineur observantin. Reveu, corrigé, augmenté, et enrichi par l’Autheur d’un excellent discours de la noblesse sur la creation des chevaliers du Sainct Sepulchre. Imprimé au cloistre de Nostre Dame des Anges, léz Liege, par Sœur Marie de la Conception et dedié a son tres-cher Pere Jean Wirix, Maÿeur de Wonck. L’an 1660. 394 ff. plus un de garde et en queue de volume, 204 x 159 mm., papier au filigrane des armes d’Amsterdam. Marque de propriété sur le f. 1r° : Hinrich Ernst, datée de 1707. La reliure est moderne. Bruxelles, Bibliothèque royale, ms. 5157-61. Notice 6: Histoire d’Ali Baba, et de quarante voleurs exterminés par une Esclave. Conte tiré des mille & une Nuit. A Liège, chez Denis de Boubers, Imprimeur-Libraire à l’Homme-Sauvage, rue du Pont. M.DCC.LXXXII. In-12, de 73 p. avec 2 fig. sur bois (p. 1 [page de titre] : un cavalier, p. 3 : vue bucolique avec village). Porte une inscription sur le premier contreplat : « Inconnu à de Theux ». Sur la première garde, note manuscrite de Victor Chauvin : « Victor Chauvin, 1 juin 1907, 1.55 f. ». Reliure cartonnée recouverte de papier marbré. Ulg, cote Chauvin 3A. [less ▲]

Detailed reference viewed: 152 (12 ULg)
Full Text
Peer Reviewed
See detailGezelle met valse noten
Steyaert, Kris ULg

in Spiegel der Letteren (2009), 51(3), 410-413

Detailed reference viewed: 37 (8 ULg)
Full Text
Peer Reviewed
See detailLa géographie, ça sert, d'abord, à faire le Monde
Breuer, Christophe ULg

in Bulletin de la Société Géographique de Liège (2009), 52

The geography is directly confronted with the societies’ problems, which it tries to answer by using its particular point of view. Specificities of the discipline generate innovation and at same time pose ... [more ▼]

The geography is directly confronted with the societies’ problems, which it tries to answer by using its particular point of view. Specificities of the discipline generate innovation and at same time pose a permanent epistemological questioning, which makes the orientation of the young geographers particularly complex. [less ▲]

Detailed reference viewed: 105 (23 ULg)
Full Text
Peer Reviewed
See detailResponse of floodplain sedimentation to catchment disturbances in different environments
Notebaert, Bastiaan; Houbrechts, Geoffrey ULg; Verstraeten, Gert et al

Poster (2009)

Holocene floodplain sediments are an important environmental archive, that can be accesed for reconstructing the past landscape dynamics either qualitatively (e.g. palynology) and quantitatively (e.g ... [more ▼]

Holocene floodplain sediments are an important environmental archive, that can be accesed for reconstructing the past landscape dynamics either qualitatively (e.g. palynology) and quantitatively (e.g. sediment budgeting). In this study Holocene alluvial sediment deposition in two contrasting Belgian catchments was quantified and dated: the Lienne (148 km²) in the Ardennes massif and the Dijle (750 km2) in the loess region. These catchments experienced a comparable Holocene climatic variation, but differ in topography and geology with highest relief energy in the Lienne catchment. Land use history also differs with high land use intensities in the Dijle catchment since Roman times, but at least since the Middle Ages there were also large deforestations in the Lienne catchment. Detailed cumulative Holocene sediment deposition was assessed for each catchment using more then 1000 hand augerings. Detailed radiocarbon dating of fluvial deposits was performed in the Dijle catchment, while iron slag was used as a tracer for sediments deposited after 1350 AD in the Lienne catchment. Results show that sediment deposition is much larger in the Dijle catchment (~4.5 Mg ha-1 catchment area) then in the Lienne catchment (~0.2 Mg ha-1 catchment area). Dating results from the Dijle catchment show an increase of sediment deposition in the late Holocene, first starting in the colluvial valleys and later on prograding towards the main valleys. Variations in sedimentation rates can clearly be related to anthropogenous land use pressure, and the majority of the sediments found in colluvial and alluvial valleys were deposited in the last 4000 years, and in many cases even in the last 1000 years. Variations in sediment deposition within the catchment can partially be explained by differences in river valley physical settings (mainly valley slope), while in other cases hill slope sediment delivery (upstream erosion, connectivity between hill slopes and the river system) is the explaining factor. In the Lienne catchment, between 80 and 100% of the sediments present in the main valley were deposited before 1350AD, thus before the main period of forest clearance. On the other hand, about 50% of the Holocene sediment present in a main tributary was deposited after 1537 (local start of iron industry). This difference with the main valley can be explained by a difference in physical settings of the river (valley slope, stream power). These results show that the physical settings of river valleys determine how sensible the river systems are to catchment disturbances. Floodplain deposition is determined by an interplay of hill slope sediment delivery (hill slope erosion and connectivity) and physical settings of the valley itself (valley slope, discharge). As a result, quantification of floodplain deposition alone, cannot be used as a measure for historic soil erosion within a catchment or to determine intensity of human impact on the catchment. [less ▲]

Detailed reference viewed: 18 (0 ULg)
Full Text
Peer Reviewed
See detailNormalizing speech transcriptions for Natural Language Processing
Dister, Anne; Constant, Matthieu; Purnelle, Gérald ULg

in Proceedings of the 3rd International Conference on Spoken Communication (GSCP'09) (2009)

Detailed reference viewed: 32 (0 ULg)
Full Text
Peer Reviewed
See detailThe dexamethasone-induced inhibition of proliferation, migration and invasion in glioma cell lines is antagonized by macrophage migration inhibitory factor (MIF) and can be enhanced by specific MIF inhibitors.
Piette, Caroline ULg; Deprez, Manuel ULg; Roger, Th et al

in Journal of Biological Chemistry (2009), 284(47), 32483-92

Glioblastomas (GBMs) are the most frequent and malignant brain tumors in adults. Glucocorticoids (GCs) are routinely used in the treatment of GBMs for their capacity to reduce the tumor-associated edema ... [more ▼]

Glioblastomas (GBMs) are the most frequent and malignant brain tumors in adults. Glucocorticoids (GCs) are routinely used in the treatment of GBMs for their capacity to reduce the tumor-associated edema. Few in vitro studies have suggested that GCs inhibit the migration and invasion of GBM cells through the induction of MAPK phosphatase 1 (MKP-1). Macrophage migration inhibitory factor (MIF), an endogenous GC antagonist is up-regulated in GBMs. Recently, MIF has been involved in tumor growth and migration/invasion and specific MIF inhibitors have been developed on their capacity to block its enzymatic tautomerase activity site. In this study, we characterized several glioma cell lines for their MIF production. U373 MG cells were selected for their very low endogenous levels of MIF. We showed that dexamethasone inhibits the migration and invasion of U373 MG cells, through a glucocorticoid receptor (GR)- dependent inhibition of the ERK1/2 MAPK pathway. Oppositely, we found that exogenous MIF increases U373 MG migration and invasion through the stimulation of the ERK1/2 MAP kinase pathway and that this activation is CD74 independent. Finally, we used the Hs 683 glioma cells that are resistant to GCs and produce high levels of endogenous MIF, and showed that the specific MIF inhibitor ISO-1 could restore dexamethasone sensitivity in these cells. Collectively, our results indicate an intricate pathway between MIF expression and GC resistance. They suggest that MIF inhibitors could increase the response of GBMs to corticotherapy. [less ▲]

Detailed reference viewed: 65 (9 ULg)
Full Text
Peer Reviewed
See detailEvaluation of saturation and microcracking of the superficial zone of concrete: new developments
Courard, Luc ULg; Lenaers, Jean-François

in Alexander, M. G.; Beushausen, H.-D.; Dehn, F. (Eds.) et al Concrete Repair, Rehabilitation and Retrofitting II (2009)

Proper surface preparation is essential for the durability of the repaired structure as well as specific saturation level of the concrete. Moreover, the repair material is often blamed for “not sticking” ... [more ▼]

Proper surface preparation is essential for the durability of the repaired structure as well as specific saturation level of the concrete. Moreover, the repair material is often blamed for “not sticking”, but the general source of the trouble lies with the substrate surface conditioning. The extensive research project has been undertaken to develop specifications and performance criteria for surface preparation of concrete substrates, one of the tasks of which was to develop a field test to evaluate the optimum moisture conditioning of the substrate concrete prior to application of repair material. The Autocalm system has been calibrated and compared with destructive and non destructive tests (Schmidt hammer, microscope observations and water absorption) on three types of concrete and two types of surface preparation. In order to evaluate different saturation levels, concrete samples have been stored in more than 12 modes of conservation. [less ▲]

Detailed reference viewed: 64 (8 ULg)
Full Text
Peer Reviewed
See detailBCOR analysis in patients with OFCD and Lenz microphthalmia syndromes, mental retardation with ocular anomalies, and cardiac laterality defects.
Hilton, Emma; Johnston, Jennifer; Whalen, Sandra et al

in European Journal of Human Genetics (2009), 17(10), 1325-35

Oculofaciocardiodental (OFCD) and Lenz microphthalmia syndromes form part of a spectrum of X-linked microphthalmia disorders characterized by ocular, dental, cardiac and skeletal anomalies and mental ... [more ▼]

Oculofaciocardiodental (OFCD) and Lenz microphthalmia syndromes form part of a spectrum of X-linked microphthalmia disorders characterized by ocular, dental, cardiac and skeletal anomalies and mental retardation. The two syndromes are allelic, caused by mutations in the BCL-6 corepressor gene (BCOR). To extend the series of phenotypes associated with pathogenic mutations in BCOR, we sequenced the BCOR gene in patients with (1) OFCD syndrome, (2) putative X-linked ('Lenz') microphthalmia syndrome, (3) isolated ocular defects and (4) laterality phenotypes. We present a new cohort of females with OFCD syndrome and null mutations in BCOR, supporting the hypothesis that BCOR is the sole molecular cause of this syndrome. We identify for the first time mosaic BCOR mutations in two females with OFCD syndrome and one apparently asymptomatic female. We present a female diagnosed with isolated ocular defects and identify minor features of OFCD syndrome, suggesting that OFCD syndrome may be mild and underdiagnosed. We have sequenced a cohort of males diagnosed with putative X-linked microphthalmia and found a mutation, p.P85L, in a single case, suggesting that BCOR mutations are not a major cause of X-linked microphthalmia in males. The absence of BCOR mutations in a panel of patients with non-specific laterality defects suggests that mutations in BCOR are not a major cause of isolated heart and laterality defects. Phenotypic analysis of OFCD and Lenz microphthalmia syndromes shows that in addition to the standard diagnostic criteria of congenital cataract, microphthalmia and radiculomegaly, patients should be examined for skeletal defects, particularly radioulnar synostosis, and cardiac/laterality defects. [less ▲]

Detailed reference viewed: 113 (2 ULg)
Full Text
See detailEU-LAC relations: from interregionalism to selective bilateralism?
Santander, Sébastian ULg

in Franck, Christian; Defraigne, Jean-Christophe; de Monriamé, Virginie (Eds.) The European Union and the Rise of Regionalism : source of Inspiration and Active Promoter (2009)

The EU has been developped an interregional strategy with the Latin American regional integration groups. However, the EU is now trying to have bilateral agreements with individual countries which is ... [more ▼]

The EU has been developped an interregional strategy with the Latin American regional integration groups. However, the EU is now trying to have bilateral agreements with individual countries which is affecting regionalism in Latin America. [less ▲]

Detailed reference viewed: 204 (14 ULg)
Full Text
Peer Reviewed
See detailWind velocity perturbation of soil respiration measurements using closed dynamic chambers
Suleau, Marie ULg; Debacq, Alain ULg; Dehaes, V. et al

in European Journal of Soil Science (2009), 60(4), 515-524

P>Soil respiration measurements performed with closed dynamic chambers are very sensitive to pressure differences inside and outside the chamber: differences as small as 1 Pa can induce errors that are of ... [more ▼]

P>Soil respiration measurements performed with closed dynamic chambers are very sensitive to pressure differences inside and outside the chamber: differences as small as 1 Pa can induce errors that are of the same magnitude as the flux itself. The problem is usually solved by adding a vent to the experimental set-up. However, although this may give acceptable results in most cases, it is not effective at sites that are very exposed to wind. At the CarboEurope-IP agricultural site of Lonzee (Belgium), on bare soil, we used a vent composed of a vertical tube whose upper end was placed between two horizontal plates. Whilst this system worked properly in low-wind conditions, it led to a significant flux over-estimation (up to 300%) under strong wind conditions. We analysed the causes of this error and attributed it to a dynamic pressure effect at the vent, leading to air aspiration from within the chamber. We suggest that this is because the wind at the vent level was not the same as that experienced in the chamber, because of the large vertical wind speed gradient close to the soil. Another vent geometry was then proposed that positioned the vent at the chamber level. This new design was tested on both manual and automatically operated chambers. It was found to be efficient in windy conditions as most of the artificial correlation between soil respiration measurements and wind speed had disappeared. [less ▲]

Detailed reference viewed: 121 (23 ULg)
Full Text
See detailcarnet de pédiatrie en Afrique: Néphrologie
Battisti, Oreste ULg

Learning material (2009)

Detailed reference viewed: 155 (43 ULg)