References of "2009"
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See detailCourse on homogenization techniques within the Finite Element modelling of Electrical Machines
V Sabariego, Ruth ULg

in Fields and material models within the finite element simulation of electrical machines (2009)

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See detailNéphrologie pédiatrique à l'usage du 3°cycle médecine
Battisti, Oreste ULg

Learning material (2009)

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See detailPrimary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case harboring API2/MALT1 gene fusion.
Bisig, Bettina ULg; Copie-Bergman, Christiane; Baia, Maryse et al

in Human Pathology (2009), 40(10), 1504-9

The genetic alterations underlying extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue type are heterogeneous and show variation according to the tumor site. Here, we report a ... [more ▼]

The genetic alterations underlying extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue type are heterogeneous and show variation according to the tumor site. Here, we report a case of mucosa-associated lymphoid tissue lymphoma of the gallbladder with genetic characterization. This lymphoma, diagnosed in a 75-year-old woman who underwent cholecystectomy for suspected acute cholecystitis, presented as diffuse thickening of the gallbladder wall. The morphology was typical of mucosa-associated lymphoid tissue lymphoma, and by immunophenotype, the tumor cells were CD20+ CD5- CD10- CD23- CD43- BCL6- BCL2+ IgM+ IgD- lambda+, with moderate nuclear expression of BCL10. Interphase fluorescence in situ hybridization analysis on paraffin sections, using a fusion probe for API2/MALT1, demonstrated 2 fusion signals in most nuclei, bringing the first documentation of a t(11;18)(q21;q21) in this exceptional primary disease location. [less ▲]

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See detailFacteurs genetiques de l'alcoolo-dependance Revue des principales donnees de la litterature.
Pinto, Emmanuel ULg; Ansseau, Marc ULg

in Encéphale (L') (2009), 35(5), 461-9

INTRODUCTION: Alcohol dependence is a complex and multifactorial disease resulting both from neurobiological mechanisms and environmental factors. It is frequently associated with comorbid psychiatric ... [more ▼]

INTRODUCTION: Alcohol dependence is a complex and multifactorial disease resulting both from neurobiological mechanisms and environmental factors. It is frequently associated with comorbid psychiatric disorders or with specific personality or behavioral features. Although action can be taken on the environment in order to decrease the risk of the illness, current methods used to prevent or to treat this pathology show moderate efficacy: problematic consumption of ethanol in the general population as well as relapse rates under treatment in dependent patients remain indeed very high. LITERATURE FINDINGS: It is therefore of major importance to broaden our knowledge of alcohol dependence and its comorbidities so as to improve both their prevention and treatment. In this perspective, recent progress in the field of neurosciences may contribute to achieve this goal. Precisely, genetics is a promising way benefiting from many advances in genetic epidemiology, cellular and molecular biology, neuroimaging and pharmacology. In parallel with a better understanding of the neurobiology of addictions and associated behaviors, these techniques led to the identification of brain mechanisms in which a genetic variation may influence the individual vulnerability towards alcohol dependence. Moreover, there is growing evidence that alcoholism results from the interaction of genetic and environmental factors influencing both its expression and its course. Given the fact that alcohol-dependence seems highly heritable (50 to 60% of the variance in both men and women), this review assesses the role of some of the genomic regions linked with the disease, as well as the principal variants of candidate genes identified as specifically involved in the predisposition. Polymorphisms of genes influencing alcohol metabolism, GABAergic, dopaminergic and serotonergic neurotransmission seem, indeed, at stake in the development of alcohol-dependence and its related features such as personality, behavior, impulse control or craving. In the future, a better characterization of the links between genotypes and phenotypes will probably increase our ability to treat alcoholic patients. [less ▲]

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See detailDynamic holographic interferometry development for dilatometry measurement of composites under vacuum-thermal conditions
Thizy, Cédric ULg; Barbier, Christian ULg; Tychon, Isabelle ULg et al

in Dirckx, J.; Buytaert, J. (Eds.) Proceedings of the 4th International Conference on Optical Measurement and Techniques for Systems & Structures (OPTIMESS 2009) (2009)

The Centre Spatial de Liège develops since 1993 holographic interferometry techniques and instruments based on photorefractive crystals for high resolution measurement of structures deformation, mainly ... [more ▼]

The Centre Spatial de Liège develops since 1993 holographic interferometry techniques and instruments based on photorefractive crystals for high resolution measurement of structures deformation, mainly for aerospace applications. In this paper we present the early results of development of a holographic technique and facility for deformation and expansion measurement of aerospace composites components. Here the holographic technique consists in using several illumination beams for retrieving different components of the displacement vector. In our case the components and structures to be measured in the future will undergo temperatures excursions up to 150°C typically. Since holographic techniques are sensitive to air turbulences, it is necessary to place the samples in a vacuum chamber. We will present some early examples of measurements with this facility, obtained for temperatures excursions ranged between ambient and 29°C as first steps before going further to higher temperatures excursions. [less ▲]

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See detailMechanisms of HTLV-1 persistence and transformation.
Boxus, Mathieu ULg; Willems, Luc ULg

in British Journal of Cancer (2009), 101(9), 1497-501

Adult T-cell leukaemia (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1). HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong immune response. In ... [more ▼]

Adult T-cell leukaemia (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1). HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong immune response. In this review, we summarise these mechanisms and their contribution to T-cell transformation and ATL development. [less ▲]

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See detailGuillain-Barré syndrome following hepatitis E
Loly, Jean-Philippe ULg; Rikir, Estelle ULg; Seivert, Maxime ULg et al

in World Journal of Gastroenterology (2009), 15(13), 1645-1647

Guillain-Barré syndrome (GBS) is often triggered by a preceding bacterial or viral infection. Occasionally, it has been observed in association with acute hepatitis A, B and C, and three cases have been ... [more ▼]

Guillain-Barré syndrome (GBS) is often triggered by a preceding bacterial or viral infection. Occasionally, it has been observed in association with acute hepatitis A, B and C, and three cases have been previously described in India in which GBS was associated with acute hepatitis E. A molecular mimicry mechanism is supposed to be involved in the pathogenesis of GBS triggered by infectious agents, although the nature of the shared epitopes has not been characterized in most instances, including that in the case of hepatotropic viruses. We report a case of GBS following acute hepatitis E in a European individual. The presence of antiganglioside GM2 antibodies in this patient suggested molecular mimicry involving ganglioside GM2 in the pathogenesis of GBS associated with hepatitis E. [less ▲]

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See detailSelf-organized mode-locking effect in superconductor/ferromagnet hybrids
Van de Vondel, J.; Silhanek, Alejandro ULg; Metlushko, V. et al

in Physical Review. B : Condensed Matter (2009), 79(5),

The vortex dynamics in a low-temperature superconductor deposited on top of a rectangular array of micrometer size permalloy triangles is investigated experimentally. The rectangular unit cell is such ... [more ▼]

The vortex dynamics in a low-temperature superconductor deposited on top of a rectangular array of micrometer size permalloy triangles is investigated experimentally. The rectangular unit cell is such that neighboring triangles physically touch each other along one direction. This design stabilizes remanent states which differ from the magnetic vortex state typical of individual noninteracting triangles. Magnetic force microscopy images have revealed that the magnetic landscape of the template can be switched to an ordered configuration after magnetizing the sample with an in-plane field. The ordered phase exhibits a broad flux-flow regime with relatively low critical current and a highly anisotropic response. This behavior is caused by the spontaneous formation of two separated rows of vortices and antivortices along each line of connected triangles. The existence of a clear flux-flow regime at zero external field supports this interpretation. The density of induced vortex-antivortex pairs is directly obtained using a high-frequency measurement technique which allows us to resolve the discrete motion of vortices. Strikingly, the presence of vortex-antivortex rows gives rise to a self-organized synchronized motion of vortices which manifests itself as field independent Shapiro steps in the current-voltage characteristics. [less ▲]

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See detailFonctions et localisation préférentielle des travaux de forge dans les campagnes du Haut-Empire de Narbonnaise : pour une approche paléométallurgique des faits archéologiques
Pagès, Gaspard ULg

in Leveau, Philippe; Raynaud, Claude; Sablayrolles, Robert (Eds.) et al Les formes de l’habitat rural gallo-romain : Terminologies et typologies à l’épreuve des réalités archéologiques, Actes du colloque AGER VIII (2009)

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See detailPsychostatistique descriptive et inférentielle Partim 2 - Exercices
Quertemont, Etienne ULg

Learning material (2009)

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See detailMucosal Gene Expression of Antimicrobial Peptides in Inflammatory Bowel Disease Before and After First Infliximab Treatment
Arijs, I.; De Hertogh, G.; Lemaire, K. et al

in PLoS ONE (2009), 4(11), 7984

Background: Antimicrobial peptides (AMPs) protect the host intestinal mucosa against microorganisms. Abnormal expression of defensins was shown in inflammatory bowel disease (IBD), but it is not clear ... [more ▼]

Background: Antimicrobial peptides (AMPs) protect the host intestinal mucosa against microorganisms. Abnormal expression of defensins was shown in inflammatory bowel disease (IBD), but it is not clear whether this is a primary defect. We investigated the impact of anti-inflammatory therapy with infliximab on the mucosal gene expression of AMPs in IBD. Methodology/Principal Findings: Mucosal gene expression of 81 AMPs was assessed in 61 IBD patients before and 4-6 weeks after their first infliximab infusion and in 12 control patients, using Affymetrix arrays. Quantitative real-time reverse-transcription PCR and immunohistochemistry were used to confirm microarray data. The dysregulation of many AMPs in colonic IBD in comparison with control colons was widely restored by infliximab therapy, and only DEFB1 expression remained significantly decreased after therapy in the colonic mucosa of IBD responders to infliximab. In ileal Crohn's disease (CD), expression of two neuropeptides with antimicrobial activity, PYY and CHGB, was significantly decreased before therapy compared to control ileums, and ileal PYY expression remained significantly decreased after therapy in CD responders. Expression of the downregulated AMPs before and after treatment (DEFB1 and PYY) correlated with villin 1 expression, a gut epithelial cell marker, indicating that the decrease is a consequence of epithelial damage. Conclusions/Significance: Our study shows that the dysregulation of AMPs in IBD mucosa is the consequence of inflammation, but may be responsible for perpetuation of inflammation due to ineffective clearance of microorganisms. [less ▲]

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See detailFrom paradigm dynamics towards landscape ecology ontogenesis
Bogaert, Jan ULg

in Farina, A. (Ed.) Ecology, Cognition and Landscape: Linking Natural and Social Systems. Landscape series 11. (2009)

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See detailRejection of pulse related artefact (PRA) from continuous electroencephalographic (EEG) time series recorded during functional magnetic resonance imaging (fMRI) using constraint independent component analysis (cICA).
Leclercq, Yves ULg; Balteau, Evelyne ULg; Dang Vu, Thien Thanh ULg et al

in NeuroImage (2009), 44(3), 679-91

Rejection of the pulse related artefact (PRA) from electroencephalographic (EEG) time series recorded simultaneously with fMRI data is difficult, particularly during NREM sleep because of the similarities ... [more ▼]

Rejection of the pulse related artefact (PRA) from electroencephalographic (EEG) time series recorded simultaneously with fMRI data is difficult, particularly during NREM sleep because of the similarities between sleep slow waves and PRA, in both temporal and frequency domains and the need to work with non-averaged data. Here we introduce an algorithm based on constrained independent component analysis (cICA) for PRA removal. This method has several advantages: (1) automatic detection of the components corresponding to the PRA; (2) stability of the solution and (3) computational treatability. Using multichannel EEG recordings obtained in a 3 T MR scanner, with and without concomitant fMRI acquisition, we provide evidence for the sensitivity and specificity of the method in rejecting PRA in various sleep and waking conditions. [less ▲]

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See detailAnalysis of perforated magnetic shields for electric power applications
Sergeant, Peter; V Sabariego, Ruth ULg; Crevecoeur, Guillaume et al

in IET Electric Power Applications (2009), 3(2), 123-132

The shielding performance of perforated magnetic shields for electric power applications is described. The shielding of an axisymmetric induction heating device is studied as a function of frequency ... [more ▼]

The shielding performance of perforated magnetic shields for electric power applications is described. The shielding of an axisymmetric induction heating device is studied as a function of frequency, number of perforations and dimensions of the perforations. From the numerical point of view, the perforations cause the numerical model to be 3D. A numerical optimisation is carried out to find the optimal geometry with respect to the shielding factor and the volume of the shield. For the optimisation, two approaches are presented. The first approach is fast and easy-to-implement, but has limited accuracy. It uses a classical 2D axisymmetric model where the perforations are approximated by ‘axisymmetric air gaps’ resulting in a segmented shield. It is shown how to modify the 2D model to obtain results that are similar to the ones of a 3D model. The second approach is more accurate although quite fast, but more difficult to implement. It combines a 3D thin- shell finite element model with the unmodified 2D model in a space mapping optimisation algorithm. The validation of both models is based on experimental work for an unperforated shield and for the optimised perforated shield. [less ▲]

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See detailDroit du travail et de la sécurité sociale
Kefer, Fabienne ULg; Clesse, Jacques ULg

Learning material (2009)

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See detailModelling the early phases of bone regeneration around an endosseous oral implant
Amor, N.; Geris, Liesbet ULg; Vander Sloten, J. et al

in Computer Methods in Biomechanics & Biomedical Engineering (2009), 12(4), 459-468

The objective of this study was to see whether a mathematical model of fracture healing was able to mimic bone formation around an unloaded screw-shaped titanium implant as it is well-believed that both ... [more ▼]

The objective of this study was to see whether a mathematical model of fracture healing was able to mimic bone formation around an unloaded screw-shaped titanium implant as it is well-believed that both processes exhibit many biological similarities. This model describes the spatio-temporal evolution of cellular activities, ranging from mesenchymal stem cell migration, proliferation, differentiation to bone formation, which are initiated and regulated by the growth factors present at the peri-implant site. For the simulations, a finite volume code was used and adequate initial and boundary conditions were applied. Two sets of analyses have been performed, in which either initial and boundary condition or model parameter values were changed with respect to the fracture healing model parameter values. For a number of combinations, the spatio-temporal evolution of bone density was well-predicted. However reducing cell proliferation rate and increasing osteoblast differentiation and osteogenic growth factor synthesis rates, the simulation results were in agreement with the experimental data. [less ▲]

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