References of "2009"
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See detailLes contrats commerciaux
Bublot, Jean ULg

in Guide des contrats et lettres types (2009)

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See detailNuclear (scintigraphic) methods and FDG-PET in rheumatoid osteoarthritis
Ribbens, Clio ULg; Hustinx, Roland ULg

in Bruno, Michael A.; Mosher, Timothy J.; Gold, Gary E. (Eds.) Arthritis in Color. Advance Imaging of Arthritis. (2009)

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See detailGestion médicale des myopathies: les premiers gestes
Votion, Dominique ULg; Van Galen, Gaby ULg; Caudron, Isabelle et al

in Pratique Vétérinaire Equine (2009), 41(numero special), 119-126

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See detailClinical, virological, and immunological parameters associated with superinfection of latently with FeHV-1 infected cats
Richter, M.; Schudel, L.; Tobler, K. et al

in Veterinary Microbiology (2009)

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See detailA prospective randomized multicenter trial of darbepoetin-alfa and I.V. iron administration after autologous hematopoietic stem cell transplantation.
Beguin, Yves ULg; Maertens, J.; DE PRIJCK, Bernard ULg et al

Poster (2009)

We conducted a multicenter prospective randomized study analyzing the impact of darbepoetin alfa (DA) with or mithout i.v. iron on erythroid recovery after autologous HCT.

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See detailUn laboratoire d’un nouveau style : sans mur ! sans mur ?
Fallon, Catherine ULg

in Département de sciences politiques de l'Université de Liège (Ed.) Entre les murs. Un collage (2009)

Quand les activités scientifiques se reconfigurent, certains murs tombent mais d’autres surgissent. Implanté au coeur de l'Université de Liège (Belgique) et physiquement intégré au CHU de Liège, le GIGA ... [more ▼]

Quand les activités scientifiques se reconfigurent, certains murs tombent mais d’autres surgissent. Implanté au coeur de l'Université de Liège (Belgique) et physiquement intégré au CHU de Liège, le GIGA (Groupe Interdisciplinaire de Génoprotéomique Appliquée) est un grand pôle de recherche et de développement d'activités dans le domaine des biotechnologies. Structure unique en son genre en Belgique, il rassemble dans un grand centre « sans mur » près de 600 chercheurs de 20 nationalités différentes (le Giga serait le 9e centre le plus intéressant pour les post-doc hors USA). Ils relèvent de la Faculté de Médecine, de Sciences, de Sciences appliquées, de Médecine vétérinaire et travaillent au sein d’une trentaine de laboratoires, regroupés autour de 7 axes de recherche pour former le Pôle GIGA-Research. Chaque unité thématique s’est adjointe pour son pilotage, un « advisory board » composé des chercheurs étrangers et belges. Le concept novateur du GIGA (laboratoires ouverts, matériel commun) favorise la pluridisciplinarité et repose sur une étroite coopération entre le monde de la recherche et celui de l'entreprise. Faire tomber les murs organisationnels : entre facultés; entre départements ; entre laboratoires et groupes de recherche. L’organisation matérielle du site a été repensée pour dépasser le concept du laboratoire scientifique dont la structure physique elle-même est placée sous la responsabilité d’un professeur, académique permanent et dont la (dé)croissance ne peut que difficilement suivre la (dé)croissance de la production scientifique de son responsable. Le nouveau concept utilise tout le potentiel de la construction en plateaux : la colonne centrale est dédiée aux équipements, matériels, animaleries, salles stériles, salles de réunions mis en commun ; les laboratoires distribués en périphéries communiquent de façon continue, les cloisons intermédiaires étant réduites au minimum, et l’espace est distribué en fonction des projets des chercheurs permanents et de leurs équipes ; enfin, les bureaux de tous les travailleurs, techniciens, doctorants, chercheurs, académiques sont disposés en bordure de plateau, face au somptueux paysage du Sart Tilman. Tous les aspects techniques ont été pensés de façon modulaire, et le nombre de places de bureau est négocié de façon régulière en fonction des contrats de recherche. Cette organisation matérielle doit favoriser la flexibilité des coopérations et les contacts entre chercheurs et entre disciplines. Un centre de recherche sans mur, permet de multiplier les occasions de fertilisations croisées, si importantes pour les projets les plus innovants, mais aussi d’optimiser l’utilisation du matériel partagé, de rassembler des moyens financiers pour payer des techniciens, de partager de l’expertise rare, voire d’investir ensemble pour de nouvelles ressources décidées au niveau du conseil de gestion. Faire tomber les murs organisationnels : entre laboratoires de recherche et clinique universitaire, pour accélérer le transfert des innovations, « from bench to bed » Le choix stratégique fait il y a 5 ans était de construire un «centre de recherche sans mur » au milieu de l’hôpital universitaire : c’est un choix unique en Belgique, l’alter ego du GIGA (le laboratoire IMI qui regroupe une vingtaine d’équipes de l’ULB) fait au même moment, dans le cadre des mêmes fonds Feder, le choix de quitter Bruxelles et l’hôpital universitaire de l’ULB pour s’installer à Gosselies, participant au choix régional de la création d’un biopôle stratégique dans le Hainaut, à deux pas de l’aéroport international. Ce choix du GIGA de rapprocher la recherche en génomique du monde médical est renforcé par la nomination du doyen de la Faculté de Médecine comme président du GIGA : il s’agit de convaincre les partenaires de l’hôpital de la proximité des approches entre chercheurs scientifiques et cliniciens. La recherche translationnelle (« translational research ») s’intéresse au transfert des idées et applications entre les laboratoires, les groupes et entreprises chargées des tests cliniques, les cliniciens, les patients et la communauté soignante. L’étape suivante sera de s’associer à des spécialistes des sciences humaines, sociologues, psychologues et anthropologues, mais aussi à des politologues capables de participer au développement de protocoles d’essais cliniques internationaux, de nouveaux régimes de contrôles de qualité, de nouveaux modèles de financements, y compris pour les contributions des systèmes publics. Faire tomber les murs institutionnels : entre chercheurs et entrepreneurs, entre laboratoires universitaires et entreprises privées, La seconde phase des travaux d’aménagement a permis de renforcer la coopération avec les entreprises spécialisées en mettant un plateau du bâtiment à leur disposition: la surface disponible est déjà entièrement utilisée par des entreprises, dont certaines, sous forme de spin off, mettent en valeur des connaissances nouvelles produites par des membres du GIGA. Pour accélérer et faciliter le transfert technologique, le GIGA travaille en étroite collaboration avec l’Interface Industrie-Université, qui peut jouer, à la demande des universitaires, un rôle de « boundary organisation » entre le monde de la recherche universitaire et celui de l’entreprise. Enfin, le soutien européen a encore permis de financer une structure pour ouvrir de nouvelles fenêtres dans les murs pour des participants occasionnels, invités à des formations organisées au sein du centre pour des demandeurs d’emplois (avec le Forem), pour des travailleurs du secteur des biotechnologies, pour des étudiants des hautes écoles. Ces fenêtres sont aussi ouvertes vers le futur, autour du développement d’un nouveau secteur économique de la région. Le GiGA a été conçu sur la base d’un postulat fondamental posé par l’équipe qui a soutenu son installation: l’importance des contacts interpersonnels dans le développement des connaissances. Même à l’âge des télécommunications, le savoir traverse les corridors et les rues plus aisément que les continents et les océans . Lors des premières étapes des inventions, les idées se transmettent surtout via des réseaux interpersonnels. Il faut établir des contacts répétés pour arriver à développer un langage commun : dans un secteur encore émergent, la science se développe suivant un nouveau paradigme et les transmissions de connaissance ne peuvent avoir lieu de façon standardisée, vu l’importance de nombreux savoirs tacites. Mais peut-on pour autant parler de la chute des murs ? Les « Trompettes de Jéricho » des innovations technologiques ont-elles réussi à faire tomber toutes les murailles qui enserrent l’université ? De nouvelles murailles pourraient se développer : entre activités scientifiques et académiques, entre société et science. Des Murs entre « Chercheurs » et « Enseignants » ? L’université en Belgique repose sur une catégorie professionnelle d’ « enseignants-chercheurs », jonglant au cours des mois entre les trois missions qui leur sont assignées : enseignement, recherche, service à la collectivité, sans oublier les nombreuses tâches d’administration interne. Ce modèle organisationnel est aujourd’hui fragilisé par l’exigence d’excellence et de compétition internationale qui favorise la spécialisation professionnelle dans le domaine de la recherche et affaiblit le pôle « enseignement » parce que la réputation internationale de l’université dépend davantage de sa recherche que de sa formation. Une université doit choisir son positionnement, entre un centre de recherche d’excellence internationale et ouvert sur le monde mais fermé sur son environnement proche, ou un centre de connaissance inscrit dans un certain territoire et ouvert aux interactions avec la société qui la finance et lui confie ses enfants. Ou choisir un nouveau modèle hybride encore à définir, comme le montrent les projets de réformes aujourd’hui en discussion dans nos universités. Des Murs de protection pour le Savoir ? Avec le développement de la « Société de la Connaissance » il est fait mention plus souvent de la nécessité de protéger les recherches, de limiter certaines publications, de repérer les innovations susceptibles d’un brevet ou d’une valorisation. Les chercheurs admettent subir des nouvelles formes de compétition : mondiales et féroces, intégrant non seulement les canons universitaires mais aussi les armes de l’entreprise grâce aux nouvelles normes en matière de propriété intellectuelle. En effet, les USA ont déjà construit des nouvelles murailles dès 1980, avec le Bayh-Dole Act qui transfère aux universités la propriété intellectuelle des connaissances produites dans le cadre de programmes publics de recherche : ce nouveau cadre légal a pour objectif un transfert plus rapide des connaissances vers des applications industrielles et commerciales, y compris au sein des universités qui doivent valoriser les résultats des travaux financés par les fonds publics La déclinaison wallonne de ce modèle date de 1998 et a été accompagnée d’un effort important des pouvoirs publics pour financer au sein des universités des bureaux de valorisation. Mais ces connaissances doivent être protégées par un brevet, valorisées dans un processus de protection qui met à mal certains principes d’ouverture et de mise en commun de la production scientifique. Les murs anciens semblent tomber pour intégrer de nouveaux modes de production de savoir. Les nouveaux murs qui vont se construire autour de la connaissance pour en garantir l’ appropriabilité, ainsi que les nouvelles structures et modes de financement public qui vont encadrer la production scientifique par les universités relèvent d’un certain choix de société. Qui en seront les architectes ? [less ▲]

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See detailPertussis in adulthood: report of two cases and review of the literature.
Poirrier, Anne-Lise ULg; Gillard, Noelle ULg; Lefèbvre, Philippe ULg et al

in Laryngoscope (2009), 119(9), 1720-2

Whooping cough is resurgent in the developed world. Systematic vaccination has changed its epidemiology, with the majority of cases now primarily affecting adolescents and adults. A 46-year-old male ... [more ▼]

Whooping cough is resurgent in the developed world. Systematic vaccination has changed its epidemiology, with the majority of cases now primarily affecting adolescents and adults. A 46-year-old male physiotherapist presented with a 1-week history of bothersome cough and respiratory difficulties, and a 51-year-old man was admitted to the emergency department with a 4-week history of increasing cough and dyspnea. Polymerase chain reaction of nasopharyngeal swab were positive for Bordetella pertussis. These cases illustrate pertussis in adulthood. We review the clinical features, the prevalence, the diagnostic tools, and the management of the patients and their relatives to increase awareness of this highly contagious disease. [less ▲]

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See detailPredictors of short-term outcome in brain-injured patients with disorders of consciousness.
Whyte, J.; Gosseries, Olivia ULg; Chervoneva, I. et al

in Progress in Brain Research (2009), 177

OBJECTIVES: To investigate predictors of recovery from the vegetative state (VS) and minimally conscious state (MCS) after brain injury as measured by the widely used Disability Rating Scale (DRS) and to ... [more ▼]

OBJECTIVES: To investigate predictors of recovery from the vegetative state (VS) and minimally conscious state (MCS) after brain injury as measured by the widely used Disability Rating Scale (DRS) and to explore differences in rate of recovery and predictors of recovery during inpatient rehabilitation in patients with non-traumatic (NTBI) and traumatic brain injury (TBI). DESIGN: Longitudinal observational cohort design and retrospective comparison study, in which an initial DRS score was collected at the time of study enrollment. Weekly DRS scores were recorded until discharge from the rehabilitation center for both NTBI and TBI patients. SETTING: Seven acute inpatient rehabilitation facilities in the United States and Europe with specialized programs for VS and MCS patients (the Consciousness Consortium). PARTICIPANTS: One hundred sixty-nine patients with a non-traumatic (N=50) and a traumatic (N=119) brain injury who were in the VS or MCS states. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: DRS score at 13 weeks after injury; change in DRS score over 6 weeks post-admission; and time until commands were first followed (for patients who did not show command-following at or within 2 weeks of admission). RESULTS: Both time between injury and enrollment and DRS score at enrollment were significant predictors of DRS score at week 13 post-injury but the main effect of etiology only approached significance. Etiology was however a significant predictor of the amount of recovery observed over the 6 weeks following enrollment. Time between injury and enrollment was also a good predictor of this outcome, but not DRS score at enrollment. For the time until commands were first followed, patients with better DRS scores at enrollment, and those with faster early rates of change recovered command following sooner than those with worse DRS scores or slower initial rates of change. The etiology was not a significant predictor for this last outcome. None of these predictive models explained sufficient variance to allow their use in individual clinical decision making. CONCLUSIONS: Time post-injury and DRS score at enrollment are predictors of early recovery among patients with disorders of consciousness, depending on the outcome measure chosen. Etiology was also a significant predictor in some analyses, with traumatically injured patients recovering more than those with non-traumatic injuries. However, the hypothesized interaction between etiology and time post-injury did not reach significance in any of the analyses suggesting that, within the time frame studied, the decline in prognosis with the passage of time was similar in the two groups. [less ▲]

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See detailGeneration of total angular momentum eigenstates in remote qubits
Maser, A.; Schilling, U.; Bastin, Thierry ULg et al

Conference (2009)

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See detailMCF-7/BOS cells membrane proteome: comparison of two isolation methods using mass spectrometry
Bertrand, Virginie ULg; Massart, Anne-Cécile ULg; De Pauw-Gillet, Marie-Claire ULg et al

Poster (2009)

Membrane proteins (MP) play an important role in biological processes. Isolation and quantification of these MP using classical techniques is often limited due to their poor solubility and relatively low ... [more ▼]

Membrane proteins (MP) play an important role in biological processes. Isolation and quantification of these MP using classical techniques is often limited due to their poor solubility and relatively low abundance. These membrane proteins enclosed markers which could be potential therapeutic targets. These potential therapeutic targets have to be accessible to antibodies and need to be presented in the plasmic membrane. Assays were conducted on MCF-7 / BOS cell line, immortal and easier to cultivate. The goal of this work is to obtain an enriched membrane fraction to facilitate the analysis of the sample and to simplify the complex proteins mixture. To isolate transmembrane proteins, we compared two methods. The first one used different extraction cycles characterized by different buffers to isolate membrane proteins. The second method labelled accessible extracellular domains at the surface of MCF-7 cells with biotin prior to differential centrifugation. The obtained enriched membrane proteome was digested with trypsin and/or Lysyl Endopeptidase. Obtained peptides were separated by 2D-HPLC chromatography and on-line analysed ion trap mass spectrometer, the Esquire HCT. [less ▲]

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See detailEstimation of genetic parameters and genome scan for 15 semen characteristics traits of Holstein bulls.
Druet, Tom ULg; Fritz, S.; Sellem, E. et al

in Journal of Animal Breeding & Genetics (2009), 126(4), 269-77

A QTL detection experiment was performed in French dairy cattle to search for QTL related to male fertility. Ten families, involving a total of 515 bulls, were phenotyped for ejaculated volume and sperm ... [more ▼]

A QTL detection experiment was performed in French dairy cattle to search for QTL related to male fertility. Ten families, involving a total of 515 bulls, were phenotyped for ejaculated volume and sperm concentration, number of spermatozoa, motility, velocity, percentage of motile spermatozoa after thawing and abnormal spermatozoa. A set of 148 microsatellite markers were used to realize a genome scan. First, genetic parameters were estimated for all traits. Semen production traits were found to have moderate heritabilities (from 0.15 to 0.30) while some of the semen quality traits such as motility had high heritabilities (close to 0.60). Genetic correlations among traits showed negative relationships between volume and concentration and between volume and most quality traits such as motility or abnormal sperm while correlations between concentration and these traits were rather favourable. Percentages of abnormal sperm were negatively related to quality traits, especially with motility and velocity of spermatozoa. Three QTL related to abnormal sperm frequencies were significant at p < 0.01. In total, 11 QTL (p < 0.05) were detected. However, the number of QTL detected was within the range of expected false positives. Because of the lack of power to find QTL in this design further analyses are required to confirm these QTL. [less ▲]

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See detailPulmonary embolism in a trauma patient with liver and orthopedic injuries
Legrain, Caroline ULg; Hans, Grégory ULg; Defresne, Aline ULg et al

in Acta Anaesthesiologica Belgica (2009), 60(4), 259-262

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See detailThe inside-out transobturator sling for the surgical treatment of post-radical prostatectomy urinary incontinence: Short term results of a prospective study
Waltregny, David ULg; Leruth, Julie ULg; de Leval, Jean ULg

in European Urology Supplements (2009), 4(8), 336

Introduction and Objective: To prospectively evaluate the short-term safety and efficacy of a new transobturator sling procedure for treating post-radical prostatectomy (RP) stress urinary incontinence ... [more ▼]

Introduction and Objective: To prospectively evaluate the short-term safety and efficacy of a new transobturator sling procedure for treating post-radical prostatectomy (RP) stress urinary incontinence (SUI). Methods: The sling technique uses specific instruments and a polypropylene mesh with 2 arms that are passed inside to outside through the obturator foramens, pulled for compressing the bulbar urethra upward, and tied to each other across the midline. Inclusion criteria were clinically and urodynamically demonstrated SUI, positive bulbar compression test, and signed informed consent. Patients with detrusor overactivity were excluded. Baseline and followup evaluations included uroflowmetry, and continence and quality of life (QoL) questionnaires. Cure was defined by no pad use and improvement by a number of pads/d ≤ 2 and reduced by at least 50%. Complications were recorded. Results: From 04/2006 through 10/2008, 70 consecutive patients who fulfilled inclusion and exclusion criteria underwent the sling procedure using the same operative protocol. As of October 2008, 55 and 35 patients who consecutively underwent the sling procedure were expected to have a minimum followup of 6 months and 1 year, respectively. Preoperatively, 13 (24%), 25 (45%), and 17 (31%) patients were using 2, 3 to 5, and >5 pads/d, respectively. Nine and 6 patients had undergone prior surgery for SUI and/or previous pelvic irradiation, respectively. The sling procedure was preceded by an endoscopic urethrotomy in 5 (9%) patients. No perioperative complication was noted. Seven (13%) patients required suprapubic catheterization; normal voiding resumed in all 7 patients except 1 who underwent urinary diversion for radiation-induced complete anastomotic stricture. Six-month and 1-year minimum followup was available on 51 (93%) and 33 (94%) patients, respectively (Table 1). Of note, at 6 months, among the 17 patients with preoperative severe incontinence (> 5 pads/day), 9 (53%) patients were cured and 6 others (35%) were improved (1 pad/d). Overall, QoL was significantly enhanced and 85% patients were moderately to completely satisfied with the procedure. Preoperative and postoperative max flow rate and postvoid residual values were not statistically different. No sling infection, urethra erosion, persistent pain or neurological complication was observed. No sling was withdrawn or cut. Conclusions: The inside-out transobturator sling procedure appears to be safe and efficient at short term. [less ▲]

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See detailMonitoring an Odour in the Environment with an Electronic Nose: Requirements for the Signal Processing
Romain, Anne-Claude ULg; Nicolas, Jacques ULg

in Gutierrez, Agustin; Marco, S. (Eds.) Biologically Inspired Signal Processing for Chemical Sensing (2009)

Artificial olfaction system (the so-called electronic nose) is a very promising tool to monitor the malodour in the field. Usual odour measurement techniques use human olfaction or analytical techniques ... [more ▼]

Artificial olfaction system (the so-called electronic nose) is a very promising tool to monitor the malodour in the field. Usual odour measurement techniques use human olfaction or analytical techniques. The first category represents the real odour perception but is not applicable to measure in continuous bad odours in the field. The second class of techniques gives the composition of the mixture but not the global information representative of the odour perception. The e-nose has the potentialities to combine “the odour perception” and the “monitoring in the field”. However to be able to reach this goal, the signal processing has to be adapted to work in complex environment. We have more than teen years experiments in the measure of environmental malodours in the field and the paper presents the minimal requirements that we consider essential for artificial olfaction system to become successful for this application. [less ▲]

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See detailAn analysis of the role of cyclin dependant kinase inhibitor 1B (CDKN1B) gene mutations in 86 families with familial isolated pituitary adenomas (FIPA)
Tichomirova, M. A.; Daly, Adrian ULg; Pujol, Julien ULg et al

in The Endocrine Society's 91st Annual Meeting : 10-13 juin 2009, Washington (2009)

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See detailLes linguistes et leurs graphiques. Introduction
Badir, Sémir ULg

in Cahiers Parisiens = Parisian Notebooks (2009), 5

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See detailEvaluation of the long-term barrier effect of commercial resorbable guided tissue regenerative membranes : an in vitro study using human gingival fibroblasts
Grenade, Charlotte ULg; Borget, Pascal; Moniotte, Nicolas et al

Poster (2009)

Introduction The first part of the study devoted to guided tissue regenerative membranes was focused on a better understanding of the physicochemical and mechanical properties of commercial materials. The ... [more ▼]

Introduction The first part of the study devoted to guided tissue regenerative membranes was focused on a better understanding of the physicochemical and mechanical properties of commercial materials. The second objective of our study was to develop an in vitro device able to measure the long-term barrier effect of resorbable membranes. After the development of this new device, experiments were realized to characterize the long-term behaviour of commercially membranes with human gingival fibroblasts (HGF). Materials and methods The use of human gingival fibroblastic cells was chosen to get closer to biological conditions. Some gingival explants were removed in young and non-smoking healthy patients. From these explants, fibroblastic cells were isolated and cultivated. These cells will be able to be used between the third and the sixth passage. Resorbable membranes were chosen because they don’t require a second surgical operation. There are made of polyesters or collagen. A system based on inserts was developed in order to follow the degradation of membranes and the migration of cells across the material. The membrane was cut into 8 mm diameter punches and set in the bottom of the system. Once the whole was put together, it is laced into a 12 wells plate culture. First, the plates were put in an incubator at 37°C, during times ranging from 24 hours to several months. The barrier effect was then measured to reflect the gradual increase of permeability of each membrane. For this purpose, HGF were seeded on the different samples. The top of the bottle and the bottom of the well were then filled with culture medium. Non degradable synthetic Bioflex membranes were chosen as control samples which don't let pass cells (porosity : 0,4 µm). After 48 hours of incubation in the presence of cells, pictures of cells on membranes and in the bottom of wells were taken with an optic microscope. Viability tests (MTS) were then realized on membranes to evaluate cells proliferation and in the bottom of wells to measure barrier effect. Finally, the morphology of cells on selected membranes was characterized by Scanning Electron Microscopy. Conclusion Proliferation results correspond to data published by several authors. Furthermore, the barrier effect times found in the present study are similar to barrier effect times demonstrated in in vivo studies and announced by manufacturers. In conclusion, the finalized system is adapted to the analysis of long-term barrier effect of commercial GTR membranes. This system will be tested with synthetic bioresorbable membranes made of copolymers. [less ▲]

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See detailDémocratie 2.0. Une histoire politique d’Internet
Lejeune, Christophe ULg

Book published by Espace de Libertés (2009)

Les technologies de l'information et de la communication interviennent de plus en plus souvent dans notre vie. Depuis sa conception, tant dans l'euphorie que dans les crises, les configurations socio ... [more ▼]

Les technologies de l'information et de la communication interviennent de plus en plus souvent dans notre vie. Depuis sa conception, tant dans l'euphorie que dans les crises, les configurations socio-techniques successives du réseau Internet ont encouragé la participation et l'autonomie de ses usagers. Depuis 20 ans (déjà), la toile accompagne également la maturation de « communautés virtuelles » ainsi que de mobilisations sociales, comme le mouvement dit « du logiciel libre » qui, se confrontant aux monopoles en tous genres, interpelle nos démocraties sur leurs liens avec la technologie. Cet ouvrage propose une réflexion nuancée sur les influences réciproques du socio-politique et de la technique. Plus qu'à un réquisitoire ou à une mise en garde, il invite à un recours actif, réfléchi et responsable à la technique dans les différentes facettes du vivre ensemble en démocratie. [less ▲]

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See detailTwo-year clinical, angiographic, and intravascular ultrasound follow-up of the XIENCE V everolimus-eluting stent in the treatment of patients with de novo native coronary artery lesions: the SPIRIT II trial.
Claessen, Bimmer E.; Beijk, Marcel A.; Legrand, Victor ULg et al

in Circulation. Cardiovascular interventions (2009), 2(4), 339-47

BACKGROUND: This article reports the 2-year clinical, angiographic, and intravascular ultrasound outcomes of the everolimus-eluting stent (EES) compared with the paclitaxel-eluting stent (PES) in the ... [more ▼]

BACKGROUND: This article reports the 2-year clinical, angiographic, and intravascular ultrasound outcomes of the everolimus-eluting stent (EES) compared with the paclitaxel-eluting stent (PES) in the randomized SPIRIT II trial. METHODS AND RESULTS: This was a prospective, single-blind clinical trial in which a total of 300 patients with de novo native coronary artery lesions were randomized to either EES or PES in a 3:1 fashion. Clinical follow-up was planned at 2 years in all patients. A subset of 152 patients underwent serial angiographic and intravascular ultrasound analyses at 6 months and 2 years. After 2 years, target lesion failure (cardiac death, myocardial infarction, and ischemia-driven target lesion revascularization) rates were 6.6% and 11% in EES and PES, respectively (P=0.31). At 6 months, a significant reduction in angiographic in-stent late loss and percentage volume obstruction measured by intravascular ultrasound was observed in the EES group. However, at 2-year follow-up, a late increased intimal hyperplasia growth after implantation of an EES was observed. There were no significant differences between EES and PES for in-stent late loss (EES, 0.33+/-0.37 mm versus PES, 0.34+/-0.34 mm; P=0.84) and percentage volume obstruction (EES, 5.18+/-6.22% versus PES, 5.80+/-6.31%; P=0.65) at 2 years. The incidence of stent thrombosis was low and comparable in both groups (EES, 0.9%; PES, 1.4%). CONCLUSIONS: Although the previously reported angiographic and clinical superiority of the EES has vanished over time, this report confirms and extends the previously demonstrated noninferiority in terms of in-stent late loss of the EES when compared with the PES up to 2-year follow-up. There were no significant differences between EES and PES in clinical, angiographic and intravascular ultrasound outcomes at 2 years. [less ▲]

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See detailWhen morphology and molecules tell us different stories: a case-in-point with Leptodon corsicus, a new and unique endemic moss species from Corsica
Sotiaux A.; Enroth, J.; Quandt, D. et al

in Journal of Bryology (2009), 31

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