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See detailTargeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with Paclitaxel
Danhier, Fabienne; Vroman, Benoît; Lecouturier, Nathalie et al

in Journal of Controlled Release (2009), 140(2), 166-173

Paclitaxel (PTX)-loaded PEGylated PLGA-based nanoparticles (NP) have been previously described as more effective in vitro and in vivo than Taxol®. The aim of this study was to test the hypothesis that our ... [more ▼]

Paclitaxel (PTX)-loaded PEGylated PLGA-based nanoparticles (NP) have been previously described as more effective in vitro and in vivo than Taxol®. The aim of this study was to test the hypothesis that our PEGylated PLGA-based nanoparticles grafted with the RGD peptide or RGD-peptidomimetic (RGDp) would target the tumor endothelium and would further enhance the anti-tumor efficacy of PTX. The ligands were grafted on the PEG chain of PCL-b-PEG included in the nanoparticles. We observed in vitro that RGD-grafted nanoparticles were more associated to Human Umbilical Vein Endothelial cells (HUVEC) by binding to αvβ3 integrin than non-targeted nanoparticles. Doxorubicin was also used to confirm the findings observed for PTX. In vivo, we demonstrated the targeting of RGD and RGDp-grafted nanoparticles to tumor vessels as well as the effective retardation of TLT tumor growth and prolonged survival times of mice treated by PTX-loaded RGD-nanoparticles when compared to non-targeted nanoparticles. Hence, the targeting of anti-cancer drug to tumor endothelium by RGD-labeled NP is a promising approach. [less ▲]

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See detailBelgian-Italian connections: decoding signals from planets
Gérard, Jean-Claude ULg

Conference given outside the academic context (2009)

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See detailPlantes d'intérieur : attention aux risques d'allergies
MARCHAL, Alan; NIKKELS, Arjen ULg

in Vers l'Avenir (2009)

Plusieurs dermatologues l'affirment : certaines fleurs et plantes d'intérieur peuvent être à l'origine d'allergies. Le point.

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See detailChina 2009. State of the Art Conference
Martiniello, Marco ULg

Scientific conference (2009, December 03)

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See detailAdding sound to movies: Historical trends and new challenges of 3D cinema
André, Cédric ULg; Embrechts, Jean-Jacques ULg; Verly, Jacques ULg

Conference (2009, December 03)

Very little research has been done so far in producing 3D sound and audio that are consistent with the 3D stereo video being viewed by the spectator. After a review of the currently used techniques for ... [more ▼]

Very little research has been done so far in producing 3D sound and audio that are consistent with the 3D stereo video being viewed by the spectator. After a review of the currently used techniques for theater sound reproduction, this talk presents new challenges of 3D cinema in terms of sound reproduction and analyse which known 3D audio techniques are able to tackle those challenges. [less ▲]

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See detailWorkshop 7 « Recent Trends in Chinese International Migration »,
Martiniello, Marco ULg

Scientific conference (2009, December 03)

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See detailDescribing an emerging disease: A case of thrombocytopenic syndrome of the newborn calf
Theron, Léonard ULg; Vogin, Nathalie; Bayrou, Calixte ULg et al

in Maillard, R.; Navetat, H. (Eds.) European buiatrics forum 2009 (2009, December 03)

Since the last 5 years, a specific hemorrhagic syndrome of unknown etiology was described in young calves. This disease has a low incidence but a very high mortality rate. No etiology has been found yet ... [more ▼]

Since the last 5 years, a specific hemorrhagic syndrome of unknown etiology was described in young calves. This disease has a low incidence but a very high mortality rate. No etiology has been found yet, though many labs have already gathered lots of cases around Europe. For example, more than 200 cases in 170 farms in Germany, 60 cases in 40 farms were described in Gent’s veterinary faculty in Belgium. In France and in the United Kingdom, several cases have been recorded yet, in multiple different locations. As far as we know, the disease concern young calves aging between 10 and 30 days, from different breeds. Most calves present a purpura on multiple sites on skin, gums, eye sclera and ears. Hematology indicates severe anemia, thrombocytopenia, neutropenia with or without leukopenia. Necropsy indicates multiple hemorrhages in serous membranes on every abdominal viscera. Alfort’s veterinary faculty has described acute necrotizing hepatitis on one case in France. Those calves are BVDV and BTV negative both on antigen tests. In Liege’s veterinary faculty one live case was examined, from a modern farm with 160 calvings, and less than 5% of calf mortality per year. The farm had 3 hemorrhagic fatal cases during July 2009, of very quick evolution. From those, 2 were autopsied and diagnosed BVDV negative. The 20 days old calf had hyperthermia in the morning, received oxytetracycline in the farm and began bleeding at noon. As many of the described cases, the calf presented mild depression with hyperthermia and tachypnoea. Skin and ear purpura, gum hematoma, melena, hematuria and hemoglobinuria were noticed. Hematology revealed a severe anemia with decreased hematocrite due to a profound thrombocytopenia (4.79*109/l). Leukocytes formula also shown neutropenia (0.10*109/l) and a monocytosis (1.32*109/l). It resulted in a mild leukopenia (3.59*109/l). We also noticed hypogammaglobulinemia (2.92 g/l and 6.8% of total protein). This calf received an immune-suppressive treatment with a high dose of dexamethasone (0.64mg/kg), and a cover antimicrobial therapy (Enrofloxacine). A good evolution of the symptoms on day 2 was observed. Leukocyte formula had a normal answer to dexamethasone concerning the lymphocytes and neutrophils population. On day 6, blood formula was already stabilized, with increasing hematocrite from 12% on day 3 to 15%. Thrombocytes count has also increased to 58.20*109/l; leukocytes count was also back to normal with normal formula. Flow cytometric measures on the lymphocytes subpopulations indicated a subnormal Gamma-Delta and Natural Killer population, and a high number of apoptotic cells 12 hours after sampling. This syndrome can be linked to idiopathic thrombocytopenia in human newborn both regarding symptomatology and treatment answer. Though this data helps in the understanding of this pathology, it concerns only one animal and needs to be confirmed through further experiment on live cases. [less ▲]

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See detailPRIX WALLON DE LA QUALITE 2009 : « La Qualité : ombre et lumière »
LEROY, Dominique; DELGAUDINE, Marie ULg

Article for general public (2009)

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See detailLes TFE en didactique des langues et littératures modernes à l'ULg. Vers une "communauté de chercheurs"
Simons, Germain ULg

Diverse speeche and writing (2009)

Depuis 2007, le service de didactique des langues et littératures modernes de l'ULg organise des séances de "mémorants" dans le domaine de la didactique des langues étrangères. Cette communication décrit ... [more ▼]

Depuis 2007, le service de didactique des langues et littératures modernes de l'ULg organise des séances de "mémorants" dans le domaine de la didactique des langues étrangères. Cette communication décrit le dispositif mis en place et propose quelques éléments d'évaluation. [less ▲]

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See detailThierry Martens et Jean de Westphalie
Adam, Renaud ULg

Conference given outside the academic context (2009)

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See detailAnalysing spectral data for the selection of a calibration model
Ziemons, Eric ULg; Moonen, François; Hubert, Philippe ULg

Patent (2009)

The invention relates to a method of analyzing spectral data for the selection of a calibration model relating spectra of a substance to a physical or chemical parameter of the substance over a ... [more ▼]

The invention relates to a method of analyzing spectral data for the selection of a calibration model relating spectra of a substance to a physical or chemical parameter of the substance over a predetermined range of the physical or chemical parameter, comprising the steps of capturing spectral data of the substance with respective values of the physical or chemical parameter over the predetermined range, applying a plurality of calibration models and mathematical pretreatments to the captured spectral data in dependence upon the values of the physical or chemical parameter, calculating tolerance intervals and a reference level for each calibration model, and displaying the tolerance intervals and the reference level over the predetermined range for each calibration model. In this way, a possibility for analyzing spectra data is provided which is useful in spectroscopic applications and makes analytical interpretation and evaluation easier and more accurate. [less ▲]

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See detailChina 2009. State of the Art Conference
Martiniello, Marco ULg

Scientific conference (2009, December 03)

Detailed reference viewed: 5 (0 ULg)
See detailLes conditions générales en droit de la construction
Kohl, Benoît ULg; Salzburger, Romain ULg

Conference (2009, December 03)

Detailed reference viewed: 35 (7 ULg)
See detailTransformed Plant Expressing a Mutansucrase and Synthesizing a Modified Starch
Jacon, Géraldine ULg; Frohberg, Claus; Vincken, Jean-Paul et al

Patent (2009)

The present invention relates to plant cells and plants, which are genetically modified, wherein the genetic modification leads to the expression in plastids of such plant cells and plants of an enzyme ... [more ▼]

The present invention relates to plant cells and plants, which are genetically modified, wherein the genetic modification leads to the expression in plastids of such plant cells and plants of an enzyme having the activity of a mutansucrase. Furthermore, the present invention relates to means and methods for the manufacture of such plant cells and plants. Plant cells and plants of this type synthesise a modified starch. The present invention therefore also relates to the starch synthesised by the plant cells and plants according to the invention as well as to methods for the manufacture of the starch and to the manufacture of starch derivatives of this modified starch. [less ▲]

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See detailMapping baseline soil content in pollutants in urbanized and industrialized areas in the Walloon region: development of a sampling methodology for the Pollusol 2 survey (SPAQuE)
Peirera, Benoit; Schneider, Arnaud; Titeux, Hugues et al

Conference (2009, December 02)

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See detailMapping of soil-sediment systems contaminations around a metal-ore smelter. The example of Cu in Lubumbashi (R.D. Congo)
Mpundu, Michel; Kaya Muyumba, Donato ULg; N'gongo, Michel et al

Conference (2009, December 02)

Detailed reference viewed: 48 (15 ULg)