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See detailBiomarker for osteoarthritis and/or other ageing-related diseases, and use thereof
Henrotin, Yves ULg; Gharbi, Myriam; Deberg, Michelle et al

Patent (2009)

The invention relates to the identification of a biomarker whose abundance in bodily fluids is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has applications ... [more ▼]

The invention relates to the identification of a biomarker whose abundance in bodily fluids is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has applications in the diagnosis of osteoarthritis and/or other ageing-related diseases, in determining the prognosis for an individual diagnosed with osteoarthritis and/or other ageing-related diseases, and in monitoring the efficacy of treatment for osteoarthritis and/or other ageing-related diseases. [less ▲]

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See detailGravitationally lensed quasars: light curves, observational constraints, modeling and the Hubble constant.
Chantry, Virginie ULg

Doctoral thesis (2009)

The central topic of this thesis is gravitational lensing, a phenomenon that occurs when light rays from a background source pass near a massive object located on the line of sight and are deflected. It ... [more ▼]

The central topic of this thesis is gravitational lensing, a phenomenon that occurs when light rays from a background source pass near a massive object located on the line of sight and are deflected. It is one of the most wonderful observational fact in favour of the General Theory of Relativity (Einstein, 1916). This phenomenon constitutes a powerful tool to probe different areas in astrophysics, including cosmology, which is our main interest. In particular we study gravitationally lensed quasars. Refsdal (1964) was the first to state that time delays between different lensed images of the same object, if this one is intrisically variable, can lead to the measurement of the Hubble constant H0, which is related the actual expansion rate of the Universe. Up to now, only a few lensed quasars have led to H0 and the precision on it has never reached the one obtained with other methods as the ones based on the Cosmic Distance Ladder. That is why some scientists from around the globe decided to unite their force to measure H0 from about thirty lensed quasars. To reach that goal, these objects are being monitored with some mid-sized ground-based telescopes located in both hemispheres. This thesis is realised in the framework of this collaboration called COSMOGRAIL for COSmological MOnitoring of GRAvItational Lenses. This work focuses on image processing and on several steps mandatory to obtain a measurement of H0 from lensed quasars: the acquisiton of the light curves from which it is possible to extract the time delays and the acquisition of the observational constraints necessary to model the gravitational potential responsible for the observed configura- tion. The central technique of this work is the image deconvolution with the MCS algorithm (Magain, Courbin & Sohy, 1998). The main principle of this algorithm is the non-violation of the sampling theorem in trying to obtain a better resolution in the deconvolved frame instead of an infinite one. The final resolution in the deconvolved frame is chosen by the user and as it is known, every image is decomposed in a contri- bution from the point sources and another one from all the extended structures such as arcs, rings and galaxies. To obtain good light curves from data coming from several telescopes, good reduction procedures are needed. That is why Vuissoz (2008) developed a semi-automated reduc- tion pipeline including deconvolution with the MCS algorithm. In the framework of the i ii Abstract present thesis, we adapt it to one of the telescopes used by the collaboration whose data were never used before, i.e. the Mercator telescope. We also bring some modifications to this pipeline, e.g. concerning the estimation of the error on the magnitudes of the light curves. We apply this revised version of the reduction pipeline to HE 0435-1223, a quadruply imaged quasar with already measured time delays (Kochanek et al., 2006). Another object, the quad WFI J2026-4536, is then investigated: we obtain light curves for each of the four lensed images. Thanks to the CASTLES project (Cfa-Arizona Space Telescope LEns Survey1), many lensed quasars have been observed with the camera 2 of NICMOS (Near Infrared Camera and Multi-Object Spectrometer ) on board the Hubble Space Telescope. With these high resolution images, we can obtain very accurate constraints on the geometry of the lensed systems. But most of the time no star is available in the field of view to obtain a good Point Spread Function (PSF). That is why we develop an iterative strategy combined with the MCS algorithm: we call it ISMCS. This technique allows to use the lensed images themselves to improve the PSFs step by step while simultaneously deconvolving the frame to obtain better estimations of the extended structures in the image. We first test this strategy on a quadruply imaged quasar, the Cloverleaf gravitational lens (H1413+117), and obtain relative positions precise to 1 milliarcsecond (mas). We then apply ISMCS to the quadruply imaged quasar WFI J2033-4723 in order to con- tribute to the estimate of the Hubble constant, as this object was monitored by our team. We then study a sample of seven lensed systems currently monitored by COSMOGRAIL and for which time delays have never been obtained. Here again, we obtain positional constraints with an accuracy of around 1 to 2 mas thanks to the application of ISMCS. We then model these systems with simple mass profiles for the main lens galaxy and obtain an estimation of the values of the time delays. Finally we apply ISMCS to a sample of eleven lensed quasars which already have measured time delays. When the delays have been remeasured by our team, in four cases until now, we also model the potential of the lens with simple mass profiles to estimate H0. 1http://www.cfa.harvard.edu/castles [less ▲]

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See detailComparing Farmer-to-Farmer Video with Workshops to Train Rural Women in Improved Rice Parboiling in Central Benin
Zossou, Enangnon ULg; Van Mele, Paul; Vodouhe, Davo Simplice et al

in Journal of Agricultural Education & Extension (2009), 15(4), 329-339

This article deals with the comparison of the conventional training based on two day community workshops and farmer-to-farmer video used as methodologies for the dissemination of improved rice parboiling ... [more ▼]

This article deals with the comparison of the conventional training based on two day community workshops and farmer-to-farmer video used as methodologies for the dissemination of improved rice parboiling process in Benin. From November 2007 to May 2008, we interviewed 160 women and 17 women groups who had been exposed to both, one or other of the methodologies. Data were analysed using ANOVA and logistic binomial regressions. Video reached more women (74%) than conventional training (27%). The conventional training was biased by participant selection, stakes in per diem payment and monopoly by the elite class. Video helped to overcome local power structures and reduced conflict at the community level. More than 95% of those who watched the video adopted drying their rice on tarpaulins and removed their shoes before stirring the rice, compared to about 50% of those who received traditional training and did not watch the video. Group use of the improved equipment was significantly higher for those who watched the video (pB0.05). By 2009, the various rice videos had been translated into over 30 African languages by Africa Rice Centre (Africa Rice) partners and involved 500 organizations and over 130,000 farmers. This study helps to give a better understanding of the role that farmer-to-farmer video could play in agricultural extension. This comparative analysis is an opportunity for a better understanding of how farmer-to-farmer video improves farmers’ practices and attitudes in agricultural technology dissemination. [less ▲]

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See detailLa prédation
Sibony, Anne-Lise ULg

Conference (2009, December 09)

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See detailCross-linked pH sensitive polymer micelles for drug delivery systems
Cajot, Sébastien ULg; Jérôme, Christine ULg

Poster (2009, December 08)

Over the last decade, polymer micelles attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. Micelles of amphiphilic block ... [more ▼]

Over the last decade, polymer micelles attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. Micelles of amphiphilic block copolymers are supramolecular core-shell type assemblies of tens of nanometers in diameter. In principle, the micelles core is usually constructed with biodegradable hydrophobic polymers such as aliphatic polyesters, e.g. poly(ɛ-caprolactone) (PCL), which serves as a reservoir for the incorporation of various lipophilic drugs. Water soluble poly(ethylene oxide) (PEO) is most frequently used to build the micelle corona because it is very efficient in preventing protein adsorption at surfaces and in stabilizing the micelles in the blood compartment, giving rise to particles invisible to the body defence system (so-called stealthy or long circulating particles). The tumour targeting of a cytotoxic agent refers to the passive accumulation of polymer nanocarriers to solid tumours (EPR effect) followed by active internalization in tumor cells. The internalization of the drug is required for cell death because most cytotoxic drugs act intracellularly. Accordingly, polymer micelles are usually modified by specific ligands. No-specific ligands can be used if their exposition is modulated by the pH decrease typical of tumour tissues. The release of the drug is ruled by diffusion and degradation of the biodegradable polymer used as reservoir. Even if micelles get a high stability in aqueous media thanks to their low critical micellar concentration, the dissociation of micelles is not always preserved when they are injected in the blood compartment. The cross-linking of the core of micelles by disulfide bridges will provide the stability of micelles after the administration and will release the drugs intracellularly by enzymatic breaking of disulfide bridges. This work consists in the development of new macromolecular architectures for the targeting of tumour cells. pH sensitive copolymers able to micellize so as non-specific ligand like biotin is exposed on their surface in response to pH decrease typical for tumour tissues will be synthesized by the incorporation of pH-sensitive linkers, e.g. imine benzoïc linkers. In addition, the core of these new micelles will be cross-linked by disulfide bridges to prevent dissociation around healthy cells and trigger the drug release inside tumour cells. [less ▲]

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See detailRetroconversion of a Complex Etymological Dictionary
Renders, Pascale ULg; Briquet, Cyril

Scientific conference (2009, December 08)

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See detailInnovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material
De Backer, Benjamin ULg; Debrus, Benjamin ULg; Lebrun, Pierre ULg et al

in Journal of Chromatography. B : Analytical Technologies in the Biomedical & Life Sciences (2009), 877(32), 4115-4124

GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms of cannabinoids are decarboxylated into their ... [more ▼]

GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms of cannabinoids are decarboxylated into their neutral counterparts. Conversely, HPLC permits the determination of the original composition of plant cannabinoids by direct analysis. Several HPLC methods have been described in the literature, but most of them failed to separate efficiently all the cannabinoids or were not validated according to general guidelines. By use of an innovative methodology for modelling chromatographic responses, a simple and accurate HPLC/DAD method was developed for the quantification of major neutral and acidic cannabinoids present in cannabis plant material: Δ9-tetrahydrocannabinol (THC), THC-acid (THCA), cannabidiol (CBD), CBD-acid (CBDA), cannabigerol (CBG), CBG-acid (CBGA) and cannabinol (CBN). Δ8-tetrahydrocannabinol (∆8-THC) was determined qualitatively. Following the practice of design of experiments, predictive multilinear models were developed and used in order to find optimal chromatographic analytical conditions. The method was validated following an approach using accuracy profiles based on β-expectation tolerance intervals for the total error measurement, and assessing the measurements uncertainty. This analytical method can be used for diverse applications, e.g. plant phenotype determination, evaluation of psychoactive potency and control of material quality. [less ▲]

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See detailContrer les effets du manque de lumière : La luminothérapie
Blain, Pascal ULg

Conference given outside the academic context (2009)

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See detailThe Emerging Role of Exercise Testing and Stress Echocardiography in Valvular Heart Disease
Picano, Eugenio; Pibarot, Philippe; Lancellotti, Patrizio ULg et al

in Journal of the American College of Cardiology (2009), 54(24), 2251-60

Exercise testing has an established role in the evaluation of patients with valvular heart disease and can aid clinical decision making. Because symptoms may develop slowly and indolently in chronic valve ... [more ▼]

Exercise testing has an established role in the evaluation of patients with valvular heart disease and can aid clinical decision making. Because symptoms may develop slowly and indolently in chronic valve diseases and are often not recognized by patients and their physicians, the symptomatic, blood pressure, and electrocardiographic responses to exercise can help identify patients who would benefit from early valve repair or replacement. In addition, stress echocardiography has emerged as an important component of stress testing in patients with valvular heart disease, with relevant established and potential applications. Stress echocardiography has the advantages of its wide availability, low cost, and versatility for the assessment of disease severity. The versatile applications of stress echocardiography can be tailored to the individual patient with aortic or mitral valve disease, both before and after valve replacement or repair. Hence, exercise-induced changes in valve hemodynamics, ventricular function, and pulmonary artery pressure, together with exercise capacity and symptomatic responses to exercise, provide the clinician with diagnostic and prognostic information that can contribute to subsequent clinical decisions. Nevertheless, there is a lack of convincing evidence that the results of stress echocardiography lead to clinical decisions that result in better outcomes, and therefore large-scale prospective randomized studies focusing on patient outcomes are needed in the future. [less ▲]

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See detail"Un homme vaut deux femmes" : La domesticité au 18e siècle dans une perspective d’histoire du genre
Stevens, Xavier ULg

Scientific conference (2009, December 08)

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See detailDes forêts et campagnes à la ville : les animaux et leurs choix
Strivay, Lucienne ULg; Mougenot, Catherine ULg

Conference (2009, December 07)

Detailed reference viewed: 13 (3 ULg)
See detailJustice et politique dans l’exorde du discours de Lycurgue Contre Léocrate
Vanhaegendoren, Koen ULg

Conference (2009, December 07)

Detailed reference viewed: 18 (2 ULg)
See detailLes Primitifs flamands
Allart, Dominique ULg

Conference given outside the academic context (2009)

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See detailSurveillance en ligne d'une machine tournante par thermographie infrarouge
Leemans, Vincent ULg; Destain, Marie-France ULg

Conference (2009, December 07)

Des mesures par thermographie d'une machine tournante critique (ventilateur) sont réalisées en ligne pour évaluer la température d’organes, comme le moteur et les paliers. En conditions de fonctionnement ... [more ▼]

Des mesures par thermographie d'une machine tournante critique (ventilateur) sont réalisées en ligne pour évaluer la température d’organes, comme le moteur et les paliers. En conditions de fonctionnement normal, les températures montrent des variations importantes, caractérisées par un écart­-type de l’ordre de 5 °C. Elles sont liées aux variations de conditions climatiques et à l'apport de chaleur variable en fonction du processus de fabrication. Un modèle auto­récurrent avec grandeurs d'entrée (ARX) a permis d'éliminer ces variations. Le bruit sur la température corrigée est réduit à un degré Celsius, ce qui permet de mettre en évidence très tôt une dégradation au niveau des paliers principaux. Par contre, dans le cas présent, le moteur subit un encrassement et donc une augmentation de température en cours de fonctionnement qui masque l’existence d’une éventuelle détérioration. [less ▲]

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See detailAbstract Numeration Systems : Recognizability, Decidability, Multidimensional S-Automatic Words, and Real Numbers
Charlier, Emilie ULg

Doctoral thesis (2009)

In this dissertation we study and we solve several questions regarding abstract numeration systems. Each particular problem is the focus of a chapter. The first problem concerns the study of the ... [more ▼]

In this dissertation we study and we solve several questions regarding abstract numeration systems. Each particular problem is the focus of a chapter. The first problem concerns the study of the preservation of recognizability under multiplication by a constant in abstract numeration systems built on polynomial regular languages. The second is a decidability problem, which has been already studied notably by J. Honkala and A. Muchnik and which is studied here for two new cases: the linear positional numeration systems and the abstract numeration systems. Next, we focus on the extension to the multidimensional setting of a result of A. Maes and M. Rigo regarding S-automatic infinite words. Finally, we propose a formalism to represent real numbers in the general framework of abstract numeration systems built on languages that are not necessarily regular. We end by a list of open questions in the continuation of the present work. [less ▲]

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See detailSynthesis of glucose-responsive hollow capsules
Alaimo, David ULg; Detrembleur, Christophe ULg; Auzély-Velty, Rachel et al

Poster (2009, December 07)

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See detailMutation politiques et socioéconomiques latino-américaines
Santander, Sébastian ULg

Conference given outside the academic context (2009)

Detailed reference viewed: 10 (0 ULg)