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See detailIdentification of the Slow-Flow Dynamics of Transonic Aeroelastic Response from Time-Series Data
Lee, Y. S.; Vakakis, Alexander F.; McFarland, D. M. et al

in 45th Technical Meeting of the Society of Engineering Science, Urbana Champaign, 2008 (2008)

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See detailThe acidic tumor microenvironment promotes the reconversion of nitrite into nitric oxide: towards a new and safe radiosensitizing strategy
Frérart, Françoise; Sonveau, Pierre; Rath, Géraldine et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (2008), 14(9), 2768-2774

PURPOSE: The biological status of nitrite recently evolved from an inactive end product of nitric oxide catabolism to the largest intravascular and tissue storage of nitric oxide (NO). Although low ... [more ▼]

PURPOSE: The biological status of nitrite recently evolved from an inactive end product of nitric oxide catabolism to the largest intravascular and tissue storage of nitric oxide (NO). Although low partial O(2) pressure favors enzymatic reconversion of nitrite into NO, low pH supports a nonenzymatic pathway. Because hypoxia and acidity are characteristics of the tumor microenvironment, we examined whether nitrite injection could preferentially lead to NO production in tumors and influence response to treatments. EXPERIMENTAL DESIGN: The effects of nitrite were evaluated on arteriole vasorelaxation, tumor cell respiration and tumor blood flow, oxygenation, and response to radiotherapy. RESULTS: We first showed that a small drop in pH (-0.6 pH unit) favored the production of bioactive NO from nitrite by documenting a higher cyclic guanosine 3',5'-monophosphate-dependent arteriole vasorelaxation. We then documented that an i.v. bolus injection of nitrite to tumor-bearing mice led to a transient increase in partial O(2) pressure in tumor but not in healthy tissues. Blood flow measurements failed to reveal an effect of nitrite on tumor perfusion, but we found that O(2) consumption by nitrite-exposed tumor cells was decreased at acidic pH. Finally, we showed that low dose of nitrite could sensitize tumors to radiotherapy, leading to a significant growth delay and an increase in mouse survival (versus irradiation alone). CONCLUSIONS: This study identified low pH condition (encountered in many tumors) as an exquisite environment that favors tumor-selective production of NO in response to nitrite systemic injection. This work opens new perspectives for the use of nitrite as a safe and clinically applicable radiosensitizing modality. [less ▲]

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See detailCarbon balance assessment of a Belgian winter wheat crop
Moureaux, Christine ULg; Debacq, Alain ULg; Hoyaux, Julien et al

in Global Change Biology (2008), 14(6), 1353-1366

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See detailComment j'explore... une metastase cutanee. Qui es-tu, d'ou viens-tu?
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Rorive, Andrée ULg et al

in Revue Médicale de Liège (2008), 63(9), 559-63

Cutaneous metastases may accompany up to 3 to 10% of all malignancies. They are usually identified after diagnosing the primary neoplasm. However, their disclosure can be synchronous, or the metastasis ... [more ▼]

Cutaneous metastases may accompany up to 3 to 10% of all malignancies. They are usually identified after diagnosing the primary neoplasm. However, their disclosure can be synchronous, or the metastasis may be the initial finding qualified as "precocious". The identification of the primary neoplasm sometimes proves to be difficult. Gender of the patient, the aspect and distribution of the metastases, as well as the histological and immunohistological examinations help establishing the diagnosis. The prognosis of the metastatic disease is often poor. [less ▲]

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See detailInvestigación y Desarrollo más Innovación
Artige, Lionel ULg; Nicolini, Rosella

Book published by Consejo Económico y Social de España (2008)

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See detailDetection of glucocorticoid bioactivity in bovine urine samples using a reporter gene assay
Connolly, Lisa; Kai, C.; Van Der Heiden, Edwige ULg et al

in Proceedings of the Euroresidue VI Conference (2008)

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See detailMaya blue-green pigments found in Calakmul, Mexico: a study by Raman and UV-visible spectroscopy
Moreno, Renata Garcia; Strivay, David ULg; Gilbert, Bernard ULg

in Journal Of Raman Spectroscopy (2008), 39(8), 1050-1056

After more than two decades of fieldwork in the Maya archaeological site of Calakmul, Mexico, numerous remnants of blue and green pigments have been reported on wall paintings, as well as on funerary ... [more ▼]

After more than two decades of fieldwork in the Maya archaeological site of Calakmul, Mexico, numerous remnants of blue and green pigments have been reported on wall paintings, as well as on funerary paraphernalia, such as masks, miniatures and vases. The importance of these pigments is linked to the sacred values that Maya people associate with blue and green colours since pre-Columbian times. These hues symbolise water, and are therefore associated with fertility and regeneration. This paper aims to perform a survey of the blue and green pigments used in the Early Classic and Late Classic periods in Calakmul (300-850 A.D.), in order to have a better understanding of their chemical composition and origin. Analyses were performed on microsamples using Raman and UV-visible spectroscopies to evaluate the possibilities that these techniques can offer in future in situ researches on Mesoamerican archaeological materials and objects. With these analyses, we have documented a large blue-green chromatic palette, which includes the earliest Blue Maya and Green Maya known to date, as well as malachite, pseudomalachite and an unknown-up-to-now blue-green mineral pigment, veszelyite, used specifically for ritual objects. The results indicate a careful selection of imported products and the mastering of a complex ancient Maya pictorial tradition. Copyright (c) 2008 John Wiley & Sons, Ltd. [less ▲]

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See detailAgonistic sounds in the skunk clownfish (Amphiprion akallopisos) : spectral and temporal basis for fish size assessment and individual recognition
Colleye, Orphal ULg; Frederich, Bruno ULg; Vandewalle, Pierre ULg et al

Poster (2008)

Clownfishes (i.e. Amphiprion akallopisos) are territorial fishes that use sound production to defend their anemone territory. They live in social groups within which there is a size-based dominance ... [more ▼]

Clownfishes (i.e. Amphiprion akallopisos) are territorial fishes that use sound production to defend their anemone territory. They live in social groups within which there is a size-based dominance hierarchy. In such a system, agonistic interactions are usual and play an important role in social organization by maintaining size differences between individuals adjacent in rank. Sounds are known to be used in agonistic interactions; they could therefore be associated with aggressive display within the group hierarchy. In the present study, we compared the sonic characteristics between individuals of different sizes and of different sexual status (non-breeder, male and female). Sound analysis revealed that dominant frequency and pulse length are highly correlated with fish size, and are not related to sex. No information related to size can be extracted from the pulse period, interpulse duration and number of pulses per train. Evidence is provided that dominant frequency and pulse length are morphologically determined signals related to fish size. In that case, smaller individuals produce shorter duration and higher frequency sounds than larger individuals. Both sonic features are signals conveying information related to the size of the emitter. This finding could be of significant importance, and might help to understand one of the mechanisms that carry the clue for individual recognition within the group hierarchy. [less ▲]

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See detailImmunosuppression in Pancreas Transplantation The Euro SPK Trials and Beyond
Malaise, J.; De Roover, Arnaud ULg; Squifflet, Jean-Paul ULg et al

in Acta Chirurgica Belgica (2008), 108

The Immunosuppression in Pancreas Transplantation was historically based on the fact that the pancreas is an extremely immunogenic organ. Quadruple drug therapy with polyclonal or monoclonal antibodies ... [more ▼]

The Immunosuppression in Pancreas Transplantation was historically based on the fact that the pancreas is an extremely immunogenic organ. Quadruple drug therapy with polyclonal or monoclonal antibodies induction was the mainstay therapy since the introduction of Cyclosporine A. In the modern era of Immunosuppression, Mycophenolate Mofetil replaced Azathioprine while Tacrolimus-another potent calcineurin inhibitor-had-and still has-a difficult challenge to replaced Cyclosporine A, due to its potential diabetogenic effect. Thanks to the first two EuroSPK studies which prospectively tried to answer several questions in that field. But, the future challenge will be in understanding the impact of innate immunity and ischemic reperfusion injuries on the long term graft function. Hopefully, new drugs will be available and tested to block unspecific deleterious reactions to attenuate the proinflammatory response. It will be the aim of the third Euro SPK Stud [less ▲]

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See detailHarmonization of strategies for the validation of quantitative analytical procedures: a SFSTP proposal part IV. Examples of application.
Hubert, Philippe ULg; Nguyen-Huu, J.-J.; Boulanger, Bruno ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2008), 48(3), 760-71

A harmonized approach for the validation of analytical methods based on accuracy profile was introduced by a SFSTP commission on the validation of analytical procedure. This fourth and last document aims ... [more ▼]

A harmonized approach for the validation of analytical methods based on accuracy profile was introduced by a SFSTP commission on the validation of analytical procedure. This fourth and last document aims at illustrating this methodology and the statistics used. Therefore the validation of real case methods are proposed such as methods for the quality control of drugs, for the quantitation of impurities in drug substances, for bioanalysis or for the determination of nutriments. Furthermore, different types of analytical methods are used in order to demonstrate the applicability of the proposed approach to a wide range of methods such as liquid chromatography (LC-UV, LC-MS), spectrophotometry or ELISA. [less ▲]

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See detailIntroduction générale
Jacquemain, Marc ULg; Perrin, Nathalie ULg

in Perrin, Nathalie; Jacquemain, Marc (Eds.) Science politique en Belgique francophone : analyser la réalité contemporaine (2008)

The general introduction presents the main themes present in frenchspeaking belgian political science today : methodology, international relations, immigration, citizenship and public involvement, public ... [more ▼]

The general introduction presents the main themes present in frenchspeaking belgian political science today : methodology, international relations, immigration, citizenship and public involvement, public acion, gender. In each of this field a general state of the art is presented. [less ▲]

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See detailEditorial
Fagnant, Annick ULg

in Cahiers des Sciences de l'Education (Les) (2008), 27-28

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See detailPeinlichkeit und Imagination
Pontzen, Alexandra ULg

in Ziemer, Gesa; Zumsteg, Simon; Huber, Jörg (Eds.) Archipele des Imaginären (2008)

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See detailIn Unordnung erstarrt
Schlagheck, Peter ULg; Richter, K.

Article for general public (2008)

Experimente mit kalten Atomen zeigen erstmals direkt die Anderson-Lokalisierung von Materiewellen.

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See detailPietätlose Rezeption? – Elfriede Jelineks Umgang mit der Tradition in „Die Kinder der Toten“.
Pontzen, Alexandra ULg

in Müller, Sabine; Theodorsen, Cathrin (Eds.) Elfriede Jelinek – Tradition, Politik und Zitat. (2008)

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See detailCalculul Constructiilor Metalice la Actiunea Focului
Franssen, Jean-Marc ULg; Zaharia, Raul

Book published by Editura Orizonturi Universitare (2008)

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See detailDes vérités diagnostiques à la réalité
QUATRESOOZ, Pascale ULg; PIERARD, Gérald ULg

Scientific conference (2008)

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