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See detailStructural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols
Lienard, Benoit M R; Garau, Gianpiero; Horsfall, Louise et al

in Organic & Biomolecular Chemistry (2008), 6(13), 2282-2294

The development of broad-spectrum metallo-beta-lactamase (MBL) inhibitors is challenging due to structural diversity and differences in metal utilisation by these enzymes. Analysis of structural data ... [more ▼]

The development of broad-spectrum metallo-beta-lactamase (MBL) inhibitors is challenging due to structural diversity and differences in metal utilisation by these enzymes. Analysis of structural data, followed by non-denturing mass spectrometric analyses, identified thiols proposed to inhibit representative MBLs from all three sub-classes: B1, B2 and B3. Solution analyses led to the identification of broad spectrum inhibitors, including potent inhibitors of the CphA MBL (Aeromonas hydrophila). Structural studies revealed that, as observed for other B1 and B3 MBLs, inhibition of the L1 MBL thiols involves metal chelation. Evidence is reported that this is not the case for inhibition of the CphA enzyme by some thiols; the crystal structure of the CphA-Zn-inhibitor complex reveals a binding mode in which the thiol does not interact with the zinc. The structural data enabled the design and the production of further more potent inhibitors. Overall the results suggest that the development of reasonably broad-spectrum MBL inhibitors should be possible. [less ▲]

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See detailDéfinition et mesure de la criminalité liée aux drogues
Born, Michel ULg; De Ruyver, B.; Lemaître, André ULg et al

Book published by Academia Press (2008)

Detailed reference viewed: 93 (20 ULg)
See detailNetworking: Employers' Groups
Dalon, Gelica; Pichault, François ULg

in Gazier, Bernard; Bruggeman, Frédéric (Eds.) Restructuring Work and Employment in Europe. Managing Change in an Era of Globalization (2008)

Studies the conditions under which employers groups can be an alternative solution to layoffs

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See detailPeut-on licencier un travailleur malade ?
Maréchal, Benoît ULg

Article for general public (2008)

This article deals with the possibility for the employer to dismiss a worker on sick leave.

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See detailStrain accommodation by slow slip and dyking in a youthful continental rift, East Africa
Calais, E.; d'Oreye, N.; Albaric, J. et al

in Nature (2008), 456

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See detailBedusted, yet not beheaded: The role of be-’s constructional properties in its conservation
Petré, Peter ULg; Cuyckens, Hubert

in Bergs, Alexander; Diewald, Gabriele (Eds.) Constructions and Language Change: Selected papers from the Workshop on Constructions and Language Change, XVII International Conference on Historical Linguistics (2008)

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See detailEffects of Non-Genetic Factors on Daily Milk Yield of Friesian Cows in Mahwa Station (South Burundi)
Hatungumukama, G.; Leroy, P. L.; Detilleux, Johann ULg

in Revue d'Elévage et de Médecine Vétérinaire des Pays Tropicaux (2008), 61(1), 45-49

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See detailRotation of axes for anisotropic metal in FEM simulations
Duchene, Laurent ULg; Lelotte, Thomas; Flores, Paulo et al

in International Journal of Plasticity (2008), (24), 397427

For the FE simulations relying on elasto-plastic models based on anisotropic yield locus description, it is important for the simulation accuracy to follow a Cartesian reference frame, where the yield ... [more ▼]

For the FE simulations relying on elasto-plastic models based on anisotropic yield locus description, it is important for the simulation accuracy to follow a Cartesian reference frame, where the yield locus is expressed. The classical formulations like the Hill 1948 model keep a constant shape of the yield locus when other texture based yield loci regularly update their shape. However in all these cases, the rotation of the Cartesian reference frame must be known. For simple shear tests performed on steel sheets, experimental displacements provide the actual updated position of initial orthogonal grids. The initial and final texture measurements give information on the average crystals rotation. For Hill constitutive law and texture based models, this paper compares the experimental results with different ways to follow the Cartesian reference frame: the co-rotational method, an original method based on the constant symmetric local velocity gradient and the Mandel spin computed by four different methods. [less ▲]

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See detailLes dispositions de la convention collective de travail: obligatoires ou normatives
Clesse, Jacques ULg

in Les 40 ans de la loi du 5 décembre 1968 sur les conventions collectives de travail (2008)

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See detailThe 18 September 1692 Earthquake in the Belgian Ardenne and its aftershocks
Alexandre, Pierre ULg; Kusman, David; Camelbeeck, Thierry et al

in Fréchet, J.; Meghraoui, M.; Stucchi, M. (Eds.) Historical Seismology. Interdisciplinary Studies of Past and Recent Earthquakes (2008)

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See detailLe stress oxydant est modifié en fonction du statut clinique chez les trotteurs à l’entraînement
Van Erck, Emmanuelle; Lekeux, Pierre ULg; Kirschvink, N.

in 36èmes Journées AVEF (2008)

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See detailLes myopathies subcliniques constituent-elles une cause d’intolérance à l’effort ?
Van Erck, Emmanuelle; Lekeux, Pierre ULg

in 36èmes Journées AVEF (2008)

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See detailRestoration assessment of calcareous grasslands in Belgium : soil conditions and floristic diversity
Piqueray, Julien ULg; Bottin, Gaëtan; Bisteau, Emmanuelle et al

Conference (2008)

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See detailAnalytical study of three cystatin C assays and their impact on cystatin C-based GFR-prediction equations.
Delanaye, Pierre ULg; Pieroni, Laurence; Abshoff, Christelle et al

in Clinica Chimica Acta (2008), 398(1-2), 118-24

BACKGROUND: Cystatin C-based equations are used to estimate GFR. However, three cystatin C immunoassays are on the market. Difference in cystatin C assays could have strong consequences on the accuracy ... [more ▼]

BACKGROUND: Cystatin C-based equations are used to estimate GFR. However, three cystatin C immunoassays are on the market. Difference in cystatin C assays could have strong consequences on the accuracy and precision of cystatin C-based equations. We have performed an analytical study of these three assays and studied potential differences between assays on the precision of cystatin C-based equations. METHODS: We have studied imprecision, recovery, linearity and interferences of the three immunoassays (nephelometric assay from Siemens and turbidimetric assays from Dako and Gentian). The impact of differences in cystatin C assays has been studied for the equations published by Levey (Siemens assay) and Grubb (Dako assay). RESULTS: Analytical performance of the Dako assay is slightly less high. For cystatin C values below 2.5 mg/L, no statistical difference is found between results given by the Dako and the Gentian assays. So, both assays can be used in the Grubb equation. Cystatin C results are different with the Siemens assay. The Levey equation, built with the Siemens assay, can only be used with cystatin C values measured with this assay. Using the Dako or Gentian assay results in the Levey equation can lead to differences in estimating GFR up to 6 mL/min/1.73 m2. Differences can reach 9.5 mL/min/1.73 m2 if the Siemens assay is used in the Grubb equation. CONCLUSION: The Siemens and Gentian assays seem analytically more valid than the Dako assay for cystatin C determination. Differences in cystatin C assays can lead to significant differences in cystatin C-based equations. However, these differences seem less important than the differences observed with creatinine and creatinine-based equations. [less ▲]

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See detailEnseigner pour diminuer les inégalités : point de vue sur la profession des enseignants et le rôle de la formation
Beckers, Jacqueline ULg; Aelterman, Antonia

in École School+ : Plate-forme pour une école sans exclusion (2008)

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See detailLe projet "Insert'Prof" : Un dispositif d'accompagnement pour les jeunes enseignants favorisant une insertion réussie dans la vie professionnelle
Beckers, Jacqueline ULg; Jardon, Dorothée; Jaspar, Steve ULg et al

in Portelance, Liliane; Mukamurera, Joséphine; Martineau, Stéphane (Eds.) et al L'insertion dans le milieu scolaire : Une phase cruciale du développement professionnel de l'enseignant (2008)

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See detailConceptualiser ses pratiques professionnelles : Un complément à l'appropriation des savoirs de recherche ?
Beckers, Jacqueline ULg

in Perrenoud, Philippe; Altet, Margueritte; Lessard, Claude (Eds.) et al Conflits de savoirs en formation des enseignants : Entre savoirs issus de la recherche et savoirs issus de l'expérience (2008)

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See detailLe droit scolaire
Maréchal, Benoît ULg

Conference (2008)

Seminar on the rights and duties at school and the admninistrative proceedings in case of litigation.

Detailed reference viewed: 103 (0 ULg)
See detailMédecine nucléaire par l'image
Seret, Alain ULg

Book published by Editions de l'Université de Liège (2008)

This book has been primarily written for the technologists and physicians working in nuclear medicine. It would however allow any interested reader to discover this fascinating medical imaging modality ... [more ▼]

This book has been primarily written for the technologists and physicians working in nuclear medicine. It would however allow any interested reader to discover this fascinating medical imaging modality. The book deals with all aspects of diagnostic nuclear medicine with images: scintigraphy and positron emission tomography. The structure of the text is the description of the nuclear procedures from their starting point to their end. Each technical and physical aspect is described on the basis of images and pictures. [less ▲]

Detailed reference viewed: 139 (24 ULg)