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See detailDe assimilatie van stem in de tussentaal van Franstalige leerders van het Nederlands
Baelen, Mélanie; Hiligsmann, Philippe; Rasier, Laurent ULg

in N/F (2008), 8

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See detailRobinson Chase F. (ed.), Texts, Documents and Artefacts. Islamic Studies in Honour of D.S. Richards
Bauden, Frédéric ULg

in Bulletin Critique des Annales Islamologiques (2008), 24

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See detailEvolution of the clinical expression of Bluetongue in Belgian cattle during year 2006 vs 2007
Guyot, Hugues ULg; Mauroy, Axel ULg; Rollin, Frédéric ULg et al

Conference (2008)

In August 2006, Belgium notified its first cases of Bluetongue (BT), serotype 8, in cattle and sheep. The disease was also observed at this time in the neighboring countries. The resurgence of BT was ... [more ▼]

In August 2006, Belgium notified its first cases of Bluetongue (BT), serotype 8, in cattle and sheep. The disease was also observed at this time in the neighboring countries. The resurgence of BT was observed in Northern Europe in 2007. The aim of the study was to compare clinical signs of BT observed in 2006 vs 2007 in Belgian cattle. The description of clinical signs was based on the observation of 38 and 39 cows in 2006 and 2007, respectively. BT cases were only included if they were confirmed by one or both laboratory diagnostic tests (competitive ELISA test and/or RT-qPCR). The inventory of clinical signs was made with a standardised clinical form for BT. This form is divided into general, cutaneous, locomotor, digestive, respiratory, neurological and reproductive clinical signs. Case data were summarised to determine changes in clinical presentation of BT between 2006 and 2007. A Fischer’s exact probability test was performed to compare (P<0.05) the frequency of clinical signs between the two years. Regarding general clinical signs, hyperthermia and tiredness were more often observed in 2007, compared to 2006. All clinical signs about skin and annexes were not significantly different between the two years. Locomotor signs such as prostration, incapacity to get up, reluctance to move, lameness and amyotrophy were more frequent in 2007. Loss of appetite, difficulties in grasping feed, salivation and drooling were the digestive signs more often observed in 2007. A purulent nasal discharge was the only respiratory sign more commonly observed in 2007. Apathy, generalised weakness and paresis or paralysis were more often encountered in 2007. The most important changes between the two years concerned reproduction. A higher incidence of abortion, premature calving and stillbirth was observed during 2007 outbreak. The frequency of most of the clinical signs of BT was higher in 2007 in Belgian cattle. Confirmed cases of BT in Belgian cattle were only 296 in 2006 compared to 4187 in 2007. These data do not represent the real situation of BT infection because the farmers do not notify all cases. Nevertheless, it seems that the 2007 outbreak was more severe regarding the number of cases and the frequency of clinical signs. The mild winter and wet 2007 summer might have favored the persistence of the vectors. [less ▲]

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See detailGroup B Streptococcal Disease in the Newborn: Maternal GBS-Screening Methods and Antimicrobial Prophylaxis
Melin, Pierrette ULg

in European Obstetrics and Gynaecology - Touch Briefings (2008), 3

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See detailLes papyrus iatromagiques grecs et la région thébaine
de Haro Sanchez, Magali ULg

in Delattre, Alain (Ed.) « Et maintenant ce ne sont plus que des villages … »: Thèbes et sa région aux époques hellénistique, romaine et byzantine. Actes du colloque tenu à Bruxelles les 2 et 3 décembre 2005 (2008)

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See detailReconstruire la ville sur la ville. Le recyclage et le renouvellement des espaces dégradés
Halleux, Jean-Marie ULg; Lambotte, Jean-Marc ULg

in Territoire(s) Wallon(s) (2008), (2), 7-22

L’article porte sur les mécanismes immobiliers qui favorisent le déclin des villes wallonnes et entravent leur recyclage morphologique. Les recherches qui y sont synthétisées portent tant sur l’action des ... [more ▼]

L’article porte sur les mécanismes immobiliers qui favorisent le déclin des villes wallonnes et entravent leur recyclage morphologique. Les recherches qui y sont synthétisées portent tant sur l’action des particuliers en matière de réhabilitation et de marché locatif que sur les stratégies des promoteurs immobiliers. Ces stratégies sont appréhendées à travers le sujet des blocages du recyclage, c’est-à-dire les différentes raisons qui poussent les opérateurs immobiliers à orienter leurs investissements vers les périphéries plutôt que vers les tissus urbains. L’article porte également sur une analyse évaluée de mesures visant à soutenir le recyclage des villes wallonnes. Trois sujets y sont particulièrement développés : les aides aux particuliers en vue de réhabiliter le parc locatif, les dispositifs de partenariat susceptibles d’orienter les promoteurs vers le milieu urbain et, enfin, les modalités susceptibles de mieux inscrire l’action publique dans une stratégie à long terme de renouvellement urbain. [less ▲]

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See detailEditorial: dermatophytes and dermatophytoses: a reappraisal for the twenty-first century
Bouchara, J. P.; Mignon, Bernard ULg; Chaturvedi, V.

in Mycopathologia (2008), 166(5-6), 235-237

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See detailAnalytic properties of different unitarization schemes
Selyugin, O. V.; Cudell, Jean-René ULg; Predazzi, E.

in Eur. Phys. J. ST (2008), 162

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See detailAnalytical study of three cystatin C assays and their impact on cystatin C-based GFR-prediction equations.
Delanaye, Pierre ULg; Pieroni, Laurence; Abshoff, Christelle et al

in Clinica Chimica Acta (2008), 398(1-2), 118-24

BACKGROUND: Cystatin C-based equations are used to estimate GFR. However, three cystatin C immunoassays are on the market. Difference in cystatin C assays could have strong consequences on the accuracy ... [more ▼]

BACKGROUND: Cystatin C-based equations are used to estimate GFR. However, three cystatin C immunoassays are on the market. Difference in cystatin C assays could have strong consequences on the accuracy and precision of cystatin C-based equations. We have performed an analytical study of these three assays and studied potential differences between assays on the precision of cystatin C-based equations. METHODS: We have studied imprecision, recovery, linearity and interferences of the three immunoassays (nephelometric assay from Siemens and turbidimetric assays from Dako and Gentian). The impact of differences in cystatin C assays has been studied for the equations published by Levey (Siemens assay) and Grubb (Dako assay). RESULTS: Analytical performance of the Dako assay is slightly less high. For cystatin C values below 2.5 mg/L, no statistical difference is found between results given by the Dako and the Gentian assays. So, both assays can be used in the Grubb equation. Cystatin C results are different with the Siemens assay. The Levey equation, built with the Siemens assay, can only be used with cystatin C values measured with this assay. Using the Dako or Gentian assay results in the Levey equation can lead to differences in estimating GFR up to 6 mL/min/1.73 m2. Differences can reach 9.5 mL/min/1.73 m2 if the Siemens assay is used in the Grubb equation. CONCLUSION: The Siemens and Gentian assays seem analytically more valid than the Dako assay for cystatin C determination. Differences in cystatin C assays can lead to significant differences in cystatin C-based equations. However, these differences seem less important than the differences observed with creatinine and creatinine-based equations. [less ▲]

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See detailRelationships between the orientation and the structural properties of peptides and their membrane interactions.
Lins, Laurence ULg; Decaffmeyer, Marc ULg; Thomas, Annick ULg et al

in Biochimica et biophysica acta (2008), 1778(7-8), 1537-44

Physical properties of membranes, such as fluidity, charge or curvature influence their function. Proteins and peptides can modulate those properties and conversely, the lipids can affect the activity and ... [more ▼]

Physical properties of membranes, such as fluidity, charge or curvature influence their function. Proteins and peptides can modulate those properties and conversely, the lipids can affect the activity and/or the structure of the former. Tilted peptides are short hydrophobic protein fragments characterized by an asymmetric distribution of their hydrophobic residues when helical. They were detected in viral fusion proteins and in proteins involved in different biological processes that need membrane destabilization. Those peptides and non lamellar lipids such as PE or PA appear to cooperate in the lipid destabilization process by enhancing the formation of negatively-curved domains. Such highly bent lipidic structures could favour the formation of the viral fusion pore intermediates or that of toroidal pores. Structural flexibility appears as another crucial property for the interaction of peptides with membranes. Computational analysis on another kind of lipid-interacting peptides, i.e. cell penetrating peptides (CPP) suggests that peptides being conformationally polymorphic should be more prone to traverse the bilayer. Future investigations on the structural intrinsic properties of tilted peptides and the influence of CPP on the bilayer organization using the techniques described in this chapter should help to further understand the molecular determinants of the peptide/lipid inter-relationships. [less ▲]

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See detailRelationship between leptin content, metabolic hormones and fat deposition in three beef cattle breeds.
Daix, Marie; Pirotte, Cécile; Bister, Jean-Loup et al

in Veterinary Journal (2008), 177

The aim of the study was to determine if cattle breeds differing in their carcass characteristics also differ in the profiles of their leptin and metabolic hormones. Three breeds, Belgian Blue (BB) (n=12 ... [more ▼]

The aim of the study was to determine if cattle breeds differing in their carcass characteristics also differ in the profiles of their leptin and metabolic hormones. Three breeds, Belgian Blue (BB) (n=12), Limousin (L) (n=12) and Aberdeen Angus (AA) (n=12) with varying ability to deposit fat and protein were compared. Blood, muscle and subcutaneous (SC) adipose tissue were sampled. Animal performance, carcass and meat characteristics were determined as well as plasma leptin concentration, leptin gene expression in SC adipose tissue, leptin-receptor gene expression in SC adipose tissue and plasma concentration of insulin, tri-iodothyronin (T3), thyroxin (T4) and cortisol. The BB bulls showed the lowest values of leptin gene expression (P<0.05). Values of plasma leptin concentration and of leptin-receptor gene expression tended to be lower in BB than in the other breeds. For a similar amount of adipose tissue (after normalisation), BB bulls showed a higher ratio of plasma leptin (P<0.05), whereas normalised leptin gene and leptin-receptor gene expressions did not significantly differ between breeds. Belgian Blue bulls also differed in their metabolic hormone profile, tending to show lower values of insulin, T3 and T4 than the two other breeds. Cortisol levels were significantly lower (P<0.05) in BB than in L and AA animals. [less ▲]

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See detailDendritic cells genetically engineered to express IL-10 induce long-lasting antigen-specific tolerance in experimental asthma.
Henry, E.; Desmet, Christophe ULg; Garze, V. et al

in Journal of Immunology (2008), 181(10), 7230-7242

Dendritic cells (DCs) are professional APCs that have a unique capacity to initiate primary immune responses, including tolerogenic responses. We have genetically engineered bone marrow-derived DCs to ... [more ▼]

Dendritic cells (DCs) are professional APCs that have a unique capacity to initiate primary immune responses, including tolerogenic responses. We have genetically engineered bone marrow-derived DCs to express the immunosuppressive cytokine IL-10 and tested the ability of these cells to control experimental asthma. A single intratracheal injection of OVA-pulsed IL-10-transduced DCs (OVA-IL-10-DCs) to naive mice before OVA sensitization and challenge prevented all of the cardinal features of airway allergy, namely, eosinophilic airway inflammation, airway hyperreactivity, and production of mucus, Ag-specific Igs, and IL-4. OVA-IL-10-DCs also reversed established experimental asthma and had long-lasting and Ag-specific effects. We furthermore showed, by using IL-10-deficient mice, that host IL-10 is required for mediating the immunomodulatory effects of OVA-IL-10-DCs and demonstrated a significant increase in the percentage of OVA-specific CD4(+)CD25(+)Foxp3(+)IL-10(+) regulatory T cells in the mediastinal lymph nodes of OVA-IL-10-DC-injected mice. Finally, adoptive transfer of CD4(+) mediastinal lymph node T cells from mice injected with OVA-IL-10-DCs protected OVA-sensitized recipients from airway eosinophilia upon OVA provocation. Our study describes a promising strategy to induce long-lasting Ag-specific tolerance in airway allergy. [less ▲]

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See detailQuelques réflexions sur le statut des enfants issus d'une union polygamique
Wautelet, Patrick ULg

in Revue du Droit des Etrangers [= RDE] (2008), 151

In this note some comments are offered on a decision issued by a civil court siting in Charleroi regarding the legal position of children born within a polygamic marriage.

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See detailNicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress.
Rongvaux, Anthony; Galli, Mara; Denanglaire, Sebastien et al

in Journal of Immunology (2008), 181(7), 4685-4695

Nicotinamide phosphoribosyl transferase (Nampt)/pre-B cell colony-enhancing factor (PBEF)/visfatin is a protein displaying multiple functional properties. Originally described as a cytokine-like protein ... [more ▼]

Nicotinamide phosphoribosyl transferase (Nampt)/pre-B cell colony-enhancing factor (PBEF)/visfatin is a protein displaying multiple functional properties. Originally described as a cytokine-like protein able to regulate B cell development, apoptosis, and glucose metabolism, this protein also plays an important role in NAD biosynthesis. To gain insight into its physiological role, we have generated a mouse strain expressing a conditional Nampt allele. Lack of Nampt expression strongly affects development of both T and B lymphocytes. Analysis of hemizygous cells and in vitro cell lines expressing distinct levels of Nampt illustrates the critical role of this protein in regulating intracellular NAD levels. Consequently, a clear relationship was found between intracellular Nampt levels and cell death in response to the genotoxic agent MNNG (N-methyl-N'-nitro-N-nitrosoguanidine), confirming that this enzyme represents a key regulator of cell sensitivity to NAD-consuming stress secondary to poly(ADP-ribose) polymerases overactivation. By using mutant forms of this protein and a well-characterized pharmacological inhibitor (FK866), we unequivocally demonstrate that the ability of the Nampt to regulate cell viability during genotoxic stress requires its enzymatic activity. Collectively, these data demonstrate that Nampt participates in cellular resistance to genotoxic/oxidative stress, and it may confer to cells of the immune system the ability to survive during stressful situations such as inflammation. [less ▲]

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See detailShort-chain fructooligosaccharides influence insulin sensitivity and gene expression of fat tissue in obese dogs.
Respondek, Frederique; Swanson, Kelly S; Belsito, Katherine R et al

in Journal of Nutrition (2008), 138(9), 1712-8

Dietary fibers may modulate insulin resistance and glucose homeostasis in dogs. Their efficacy is, however, dependent on their origin, physical properties, and fermentability in the large bowel. Eight ... [more ▼]

Dietary fibers may modulate insulin resistance and glucose homeostasis in dogs. Their efficacy is, however, dependent on their origin, physical properties, and fermentability in the large bowel. Eight healthy Beagle dogs were fed a commercial diet at twice their maintenance requirements until they became obese. They were then maintained in the obese state and used in a cross-over design study to evaluate the effects of short-chain fructooligosaccharide (scFOS) supplementation (1% wt:wt dry matter in the diet). The euglycemic hyperinsulinemic clamp technique was performed before and after fattening and at the end of each 6-wk cross-over period. Fat tissue biopsies were taken in food-deprived and postprandial phases to measure mRNA abundance of genes involved with fatty acid, glucose metabolism, or inflammation. Insulin resistance appeared progressively with fattening and the rate of glucose infusion during euglycemic clamp was lower (P < 0.05) at the end of the fattening period (7.39 mg.kg(-1).min(-1)) than at baseline (21.21 mg.kg(-1).min(-1)). In stable obese dogs, scFOS increased (P < 0.05) the rate of glucose infusion compared with control (7.77 vs. 4.72 mg.kg(-1).min(-1)). Plasma insulin and triglyceride concentrations were greater in obese than in lean dogs but were not altered by scFOS. Whereas mRNA was not affected in food-deprived dogs, scFOS increased uncoupling protein 2 (P = 0.05) and tended to increase carnitine palmitoyl transferase 1 adipose mRNA levels during the postprandial period (P = 0.09). Adding 1% scFOS to the diet of obese dogs decreases insulin resistance and appears to modulate the transcription of genes involved in fatty acid or glucose metabolism. [less ▲]

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See detailDe l'esquisse à la maquette digitale : transformation des représentations graphiques en modèles numériques pour l'ingénierie de conception.
Elsen, Catherine ULg; Leclercq, Pierre ULg

Conference (2008)

Ce projet s’intéresse à la place que tient aujourd’hui l’esquisse et les représentations 3D au sein du processus de conception, et plus particulièrement au sein des phases amont de la création chez les ... [more ▼]

Ce projet s’intéresse à la place que tient aujourd’hui l’esquisse et les représentations 3D au sein du processus de conception, et plus particulièrement au sein des phases amont de la création chez les designers de produit. La question posée est la pertinence de l’esquisse au sein du système global des représentations externes et sa place actuelle dans le monde des possibles offerts par la CAO. La finalité de la recherche est l’objectivation d’un concept IHM pouvant effectivement et efficacement supporter les designers en phase créative. [less ▲]

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See detailEnvahissement des cuvettes par apports éoliens: processus, impacts et moyens de lutte
Ambouta, Karimou J-M; Tychon, Bernard ULg

in Tropicultura (2008), 26

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See detailMeridional reorganizations of marine and terrestrial productivity during Heinrich events,
Menviel, L.; Timmermann, A.; Mouchet, Anne ULg et al

in Paleoceanography (2008), 23

To study the response of the global carbon cycle to a weakening of the Atlantic Meridional Overturning Circulation (AMOC), a series of freshwater perturbation experiments is conducted both under ... [more ▼]

To study the response of the global carbon cycle to a weakening of the Atlantic Meridional Overturning Circulation (AMOC), a series of freshwater perturbation experiments is conducted both under preindustrial and glacial conditions using the earth system model of intermediate complexity LOVECLIM. A shutdown of the AMOC leads to substantial cooling of the North Atlantic, a weak warming of the Southern Hemisphere, intensification of the northeasterly trade winds, and a southward shift of the Intertropical Convergence Zone (ITCZ). Trade wind anomalies change upwelling in the tropical oceans and hence marine productivity. Furthermore, hydrological changes associated with a southward displacement of the ITCZ lead to a reduction of terrestrial carbon stocks mainly in northern Africa and northern South America in agreement with paleoproxy data. In the freshwater perturbation experiments the ocean acts as a sink of CO2, primarily through increased solubility. The net atmospheric CO2 anomaly induced by a shutdown of the AMOC amounts to about +15 ppmv and −10 ppmv for preindustrial and glacial conditions, respectively. This background state dependence can be explained by the fact that the glacial climate is drier and the terrestrial vegetation therefore releases a smaller amount of carbon to the atmosphere. This study demonstrates that the net CO2 response to large-scale ocean circulation changes has significant contributions both from the terrestrial and marine carbon cycle. [less ▲]

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See detailSedimentological Fingerprints of Recent Earthquakes in Lake Sediments: A Case Study on the North Anatolian Fault (NAF), Turkey
Avsar, U.; Boes, X.; Hubert-Ferrari, A. et al

Poster (2008)

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