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See detailTARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas.
Thielen, Caroline ULg; Radermacher, Vincent ULg; Trimeche, Mounir et al

in Leukemia Research (2008), 32(9), 1431-8

The current study attempts to characterize the eosinophilia associated with T-cell lymphomas and to investigate its possible relationship with the secretion of eosinophil-stimulating factors by lymphoma ... [more ▼]

The current study attempts to characterize the eosinophilia associated with T-cell lymphomas and to investigate its possible relationship with the secretion of eosinophil-stimulating factors by lymphoma cells and/or intra-tumoral surrounding cells. Paraffin-embedded specimens from 50 patients diagnosed with peripheral T-cell lymphomas, either unspecified (PTCL-U, n=30) or angioimmunoblastic (AITL, n=20) were morphologically assessed for intra-tumoral eosinophilia and analyzed by immunohistochemistry using specific antibodies directed against TARC, IL-5, RANTES, and eotaxin. The AITL and PTCL-U cases contained a mean of 147+/-41 and 102+/-37 eosinophils per 10 high power fields, respectively. Thirty-two of 47 cases (68%) showed IL-5-positive lymphoma cells while 15/50 (30%) tumors showed variable staining for TARC in scattered non-lymphoid cells with dendritic morphology. TARC and IL-5-positive cases possessed significantly more eosinophils. Our data indicate that IL-5 and TARC expression highly correlate with eosinophilia in T-cell lymphomas, suggesting that these chemokines are involved in the recruitment of eosinophils into the tumors. [less ▲]

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See detailMajor clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the SMART study.
Emery, Sean; Neuhaus, Jacqueline A; Phillips, Andrew N et al

in Journal of Infectious Diseases (2008), 197(8), 1133-44

BACKGROUND: The SMART study randomized 5,472 human immunodeficiency virus (HIV)-infected patients with CD4+ cell counts >350 cells/microL to intermittent antiretroviral therapy (ART; the drug conservation ... [more ▼]

BACKGROUND: The SMART study randomized 5,472 human immunodeficiency virus (HIV)-infected patients with CD4+ cell counts >350 cells/microL to intermittent antiretroviral therapy (ART; the drug conservation [DC] group) versus continuous ART (the viral suppression [VS] group). In the DC group, participants started ART when the CD4+ cell count was <250 cells/microL. Clinical outcomes in participants not receiving ART at entry inform the early use of ART. METHODS: Patients who were either ART naive (n=249) or who had not been receiving ART for >or= 6 months (n=228) were analyzed. The following clinical outcomes were assessed: (i) opportunistic disease (OD) or death from any cause (OD/death); (ii) OD (fatal or nonfatal); (iii) serious non-AIDS events (cardiovascular, renal, and hepatic disease plus non-AIDS-defining cancers) and non-OD deaths; and (iv) the composite of outcomes (ii) and (iii). RESULTS: A total of 477 participants (228 in the DC group and 249 in the VS group) were followed (mean, 18 months). For outcome (iv), 21 and 6 events occurred in the DC (7 in ART-naive participants and 14 in those who had not received ART for >or= 6 months) and VS (2 in ART-naive participants and 4 in those who had not received ART for 6 months) groups, respectively. Hazard ratios for DC vs. VS by outcome category were as follows: outcome (i), 3.47 (95% confidence interval [CI], 1.26-9.56; p=.02); outcome (ii), 3.26 (95% CI, 1.04-10.25; p=.04); outcome (iii), 7.02 (95% CI, 1.57-31.38; p=.01); and outcome (iv), 4.19 (95% CI, 1.69-10.39; p=.002 ). CONCLUSIONS: Initiation of ART at CD4+ cell counts >350 cells/microL compared with <250 cells/microL may reduce both OD and serious non-AIDS events. These findings require validation in a large, randomized clinical trial. [less ▲]

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See detailLa démarche scientifique expérimentale en formation initiale d'enseignants du fondamental : analyse d'un module de formation
Hindryckx, Marie-Noëlle ULg

in Cahiers des Sciences de l'Education (Les) (2008), 27/28

Dans le cadre d'une recherche AGERS intitulée: "Pour une formation des futurs instituteurs à une autre didactique des sciences à l'école primaire. Recherche-action pluridisciplinaire visant à la maîtrise ... [more ▼]

Dans le cadre d'une recherche AGERS intitulée: "Pour une formation des futurs instituteurs à une autre didactique des sciences à l'école primaire. Recherche-action pluridisciplinaire visant à la maîtrise de l'enseignement de la démarche scientifique" des modules d'activités ont été construits. Le présent article raconte la mise en oeuvre de ce type d'activités et ses enjeux, en formation initiale des enseignants de première année en maternelle, lors d'ateliers de formation professionnelle (AFP). [less ▲]

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See detailInferior clinical outcome of the CD4+ cell count-guided antiretroviral treatment interruption strategy in the SMART study: role of CD4+ Cell counts and HIV RNA levels during follow-up.
Lundgren, Jens D; Babiker, Abdel; El-Sadr, Wafaa et al

in Journal of Infectious Diseases (2008), 197(8), 1145-55

BACKGROUND AND METHODS: The SMART study compared 2 strategies for using antiretroviral therapy-drug conservation (DC) and viral suppression (VS)-in 5,472 human immunodeficiency virus (HIV)-infected ... [more ▼]

BACKGROUND AND METHODS: The SMART study compared 2 strategies for using antiretroviral therapy-drug conservation (DC) and viral suppression (VS)-in 5,472 human immunodeficiency virus (HIV)-infected patients with CD4+ cell counts >350 cells/microL. Rates and predictors of opportunistic disease or death (OD/death) and the relative risk (RR) in DC versus VS groups according to the latest CD4+ cell count and HIV RNA level are reported. RESULTS: During a mean of 16 months of follow-up, DC patients spent more time with a latest CD4+ cell count <350 cells/microL (for DC vs. VS, 31% vs. 8%) and with a latest HIV RNA level >400 copies/mL (71% vs. 28%) and had a higher rate of OD/death (3.4 vs. 1.3/100 person-years) than VS patients. For periods of follow- up with a CD4+ cell count <350 cells/microL, rates of OD/death were increased but similar in the 2 groups (5.7 vs. 4.6/100 person-years), whereas the rates were higher in DC versus VS patients (2.3 vs. 1.0/100 person-years; RR, 2.3 [95% confidence interval, 1.5-3.4]) for periods with the latest CD4+ cell count >or= 350 cells/microL-an increase explained by the higher HIV RNA levels in the DC group. CONCLUSIONS: The higher risk of OD/death in DC patients was associated with (1) spending more follow-up time with relative immunodeficiency and (2) living longer with uncontrolled HIV replication even at higher CD4+ cell counts. Ongoing HIV replication at a given CD4+ cell count places patients at an excess risk of OD/death. [less ▲]

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See detailStress oxydant et antioxydants: mythes et réalités.
Defraigne, Jean-Olivier ULg; Pincemail, Joël ULg

in Revue Médicale de Liège (2008), 63

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See detailDiscrimination of parasitized aphids by a hoverfly predator: effects on larval performance, foraging, and oviposition behavior
Almohamad, Raki; Verheggen, François ULg; Francis, Frédéric ULg et al

in Entomologia Experimentalis et Applicata (2008), 128(1), 73-80

The choice of oviposition site by female aphidophagous predators is crucial for offspring performance, especially in hoverflies whose newly hatched larvae are unable to move over large distance. Predator ... [more ▼]

The choice of oviposition site by female aphidophagous predators is crucial for offspring performance, especially in hoverflies whose newly hatched larvae are unable to move over large distance. Predator and parasitoid interactions within the aphidophagous guild are likely to be very important in influencing the choices made by predatory hoverfly females. In the present study, the foraging and oviposition behavior of the aphidophagous hoverfly Episyrphus balteatus DeGeer (Diptera: Syrphidae) was investigated with respect to the parasitized state of its aphid prey, Acyrthosiphon pisum Harris (Homoptera: Aphididae), that were parasitized by Aphidius ervi Haliday (Hymenoptera: Aphidiidae). We also recorded the number of eggs laid by hoverfly females when subjected to parasitized aphids. Furthermore, we studied the influence of being fed with parasitized aphids on hoverfly larval performance. Hoverfly females did not exhibit any preference for plants infested with unparasitized or aphids parasitized for 7 days. On the other hand, plants infested with mummies or exuvia were less attractive for E. balteatus. These results were correlated with (i) the number of eggs laid by E. balteatus females and (ii) larval performance. Thus, our results demonstrate that E. balteatus behavior is affected by parasitoid presence through their exploitation of aphid colonies. Indeed, hoverfly predators select their prey according to the developmental state of the parasitoid larvae. [less ▲]

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See detailStatistical Analysis of the night weather conditions favouring the epidemic of the brown rust in the Grand-Duchy of Luxemburg.
El Jarroudi, Moussa ULg; Tychon, Bernard ULg; Maraite, H. et al

in Italian Journal of Agronomy [=IJA] = Rivista di Agronomia (2008), 3(3), 611-612

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See detailSubgroup and resistance analyses of raltegravir for resistant HIV-1 infection.
Cooper, David A; Steigbigel, Roy T; Gatell, Jose M et al

in New England Journal of Medicine [=NEJM] (2008), 359(4), 355-65

BACKGROUND: We evaluated the efficacy of raltegravir and the development of viral resistance in two identical trials involving patients who were infected with human immunodeficiency virus type 1 (HIV-1 ... [more ▼]

BACKGROUND: We evaluated the efficacy of raltegravir and the development of viral resistance in two identical trials involving patients who were infected with human immunodeficiency virus type 1 (HIV-1) with triple-class drug resistance and in whom antiretroviral therapy had failed. METHODS: We conducted subgroup analyses of the data from week 48 in both studies according to baseline prognostic factors. Genotyping of the integrase gene was performed in raltegravir recipients who had virologic failure. RESULTS: Virologic responses to raltegravir were consistently superior to responses to placebo, regardless of the baseline values of HIV-1 RNA level; CD4 cell count; genotypic or phenotypic sensitivity score; use or nonuse of darunavir, enfuvirtide, or both in optimized background therapy; or demographic characteristics. Among patients in the two studies combined who were using both enfuvirtide and darunavir for the first time, HIV-1 RNA levels of less than 50 copies per milliliter were achieved in 89% of raltegravir recipients and 68% of placebo recipients. HIV-1 RNA levels of less than 50 copies per milliliter were achieved in 69% and 80% of the raltegravir recipients and in 47% and 57% of the placebo recipients using either darunavir or enfuvirtide for the first time, respectively. At 48 weeks, 105 of the 462 raltegravir recipients (23%) had virologic failure. Genotyping was performed in 94 raltegravir recipients with virologic failure. Integrase mutations known to be associated with phenotypic resistance to raltegravir arose during treatment in 64 patients (68%). Forty-eight of these 64 patients (75%) had two or more resistance-associated mutations. CONCLUSIONS: When combined with an optimized background regimen in both studies, a consistently favorable treatment effect of raltegravir over placebo was shown in clinically relevant subgroups of patients, including those with baseline characteristics that typically predict a poor response to antiretroviral therapy: a high HIV-1 RNA level, low CD4 cell count, and low genotypic or phenotypic sensitivity score. (ClinicalTrials.gov numbers, NCT00293267 and NCT00293254.) [less ▲]

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See detailApplication of mechanoregulatory models to simulate peri-implant tissue formation in an in vivo bone chamber
Geris, Liesbet ULg; Vandamme, Katleen; Naert, Ignace et al

in Journal of Biomechanics (2008), 41(1), 145-154

Several mechanoregulatory tissue differentiation models have been proposed over the last decade. Corroboration of these models by comparison with experimental data is necessary to determine their ... [more ▼]

Several mechanoregulatory tissue differentiation models have been proposed over the last decade. Corroboration of these models by comparison with experimental data is necessary to determine their predictive power. So far, models have been applied with various success rates to different experimental set-ups investigating mainly secondary fracture heating. In this study, the mechanoregulatory models are applied to simulate the implant osseointegration process in a repeated sampling in vivo bone chamber, placed in a rabbit tibia. This bone chamber provides a mechanically isolated environment to study tissue differentiation around titanium implants loaded in a controlled manner. For the purpose of this study, bone formation around loaded cylindrical and screw-shaped implants was investigated. Histologically, no differences were found between the two implant geometries for the global amount of bone formation in the entire chamber. However, a significantly larger amount of bone-to-implant contact was observed for the screw-shaped implant compared to the cylindrical implant. In the simulations, a larger amount of bone was also predicted to be in contact with the screw-shaped implant. However, other experimental observations could not be predicted. The simulation results showed a distribution of cartilage, fibrous tissue and (im)mature bone, depending on the mechanoregulatory model that was applied. In reality, no cartilage was observed. Adaptations to the differentiation models did not lead to a better correlation between experimentally observed and numerically predicted tissue distribution patterns. The hypothesis that the existing mechanoregulatory models were able to predict the patterns of tissue formation in the in vivo bone chamber could not be fully sustained. (c) 2007 Elsevier Ltd. All rights reserved. [less ▲]

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See detailCavernous hemangiosarcoma in a free-living red deer (Cervus elaphus)
Grégoire, Fabien ULg; Mousset, Bénédicte ULg; Hanrez, David ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2008), 162

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See detailLes tumeurs de la sphere ORL: standards de traitement et nouvelles approches en radiotherapie.
Coucke, Philippe ULg; Piret, Pascal ULg; Werenne, Xavier ULg et al

in Revue Médicale de Liège (2008), 63(3), 141-8

We intend to review the general value of radiotherapy in the management of head and neck cancer. Our aim is to define a treatment protocol which is evidence-based and therefore of use in daily clinical ... [more ▼]

We intend to review the general value of radiotherapy in the management of head and neck cancer. Our aim is to define a treatment protocol which is evidence-based and therefore of use in daily clinical practice. There is general agreement on the efficacy of the concomitant schedules combining radiotherapy and chemotherapy, both in the adjuvant setting as well as in the exclusive non-surgical approach. This however does not preclude further research aiming at optimizing the therapeutic index. As far as neoadjuvant chemotherapy is concerned, applied prior to radical local treatment, there are no conclusive data available which allows us to implement this treatment option in routine clinical practice. This approach deserves further investigations and patients should be entered in well designed prospective randomized trials. [less ▲]

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See detailWhat makes Episyrphus balteatus (Diptera: Syrphidae) oviposit on aphid infested tomato plants?
Verheggen, François ULg; Capella, Quentin ULg; Wathelet, Jean-Paul ULg et al

in Communications in Agricultural and Applied Biological Sciences (2008), 73(3), 371-81

Under attack by insect pests, many plant species change their volatile chemical emissions to attract natural enemies. Most of the tomato (Lycopersicon sp., Solanaceae) varieties are subjected to ... [more ▼]

Under attack by insect pests, many plant species change their volatile chemical emissions to attract natural enemies. Most of the tomato (Lycopersicon sp., Solanaceae) varieties are subjected to infestation by molluscs and insects, including the generalist aphid Myzus persicae Sulzer (Homoptera, Aphididae). Episyrphus balteatus De Geer (Diptera: Syrphidae) is a generalist aphid predator that was here observed to lay eggs on M. persicae infested tomato but not on non-infested plants. In order to identify the volatile chemicals that guide the foraging and oviposition behaviour of E. balteatus, we collected and identified volatiles released in the headspace of both aphid infested and uninfested tomato plants by SPME-GC-MS. The identified chemicals were subsequently tested by electroantennography (EAG) on E. balteatus. Monoterpenes and sesquiterpenes were identified, the main volatile chemicals being beta-phellandrene, 2-carene, alpha-phellandrene, 3-carene and o-pinene. Electrical depolarizations were observed for each tested monoterpene, with optimal responses ranging from -0.2 to -0.8 mV. Episyrphus balteatus antennae showed dose-response relationships towards all the active chemicals. (E)-beta-farnesene, the main component of the aphid alarm pheromone, was the only active sesquiterpene, and is presumed to act as an oviposition stimulus for E. balteotus. [less ▲]

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See detailLes vaccins contre la FCO protègent-ils le foetus?
Thiry, Etienne ULg

in Point Vétérinaire (2008), 287

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See detailEvaluation du potentiel antioxydant et de la propriété antiproliférative de l’huile essentielle d’armoise blanche du Maroc oriental
Imelouane, B.; Amjamdi, H.; Dubois, J. et al

Poster (2008)

La présente communication est consacrée à l’étude du pouvoir antioxydant de l’huile essentielle de l’armoise blanche. Les résultats obtenus montrent qu’effectivement l’huile essentielle de l’armoise et ... [more ▼]

La présente communication est consacrée à l’étude du pouvoir antioxydant de l’huile essentielle de l’armoise blanche. Les résultats obtenus montrent qu’effectivement l’huile essentielle de l’armoise et riche en antioxydant et inhibe le développement de quelques lignées cellulaires. [less ▲]

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See detailNeural network involved in self-judgment in young and elderly adults
Feyers, Dorothée ULg

Master of advanced studies dissertation (2008)

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See detailSupports visuels réalisés dans le cadre des travaux pratiques de Chimie Analytique (Partie II)
Ziemons, Eric ULg; Lejeune, Robert ULg; Hubert, Philippe ULg

Learning material (2008)

Plusieurs vidéos (étalonnage des pipettes, argentimétrie: méthode de Fajans et argentimétrie: méthode de Mohr) illustrent les manipulations des travaux pratiques de 2ème Baccalauréat en Sciences ... [more ▼]

Plusieurs vidéos (étalonnage des pipettes, argentimétrie: méthode de Fajans et argentimétrie: méthode de Mohr) illustrent les manipulations des travaux pratiques de 2ème Baccalauréat en Sciences pharmaceutiques. [less ▲]

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See detailL’influence de l’anxiété sur l’excitation sexuelle : Vers une théorie cognitive
Kempeneers, Philippe ULg; Barbier, Valérie

in Sexologies (2008), 17(2), 66-75

For ages, anxiety has been pointed out as the main etiological factor for sexual dysfunction. Since Wolpe, Masters & Johnson and Kaplan, the understanding of the influence of stress on sexual reactions ... [more ▼]

For ages, anxiety has been pointed out as the main etiological factor for sexual dysfunction. Since Wolpe, Masters & Johnson and Kaplan, the understanding of the influence of stress on sexual reactions has greatly evolved. This article retraces the milestones of such an evolution. In two decades, the reciprocal inhibitory theory has been replaced by a theory describing more accurately the complex relationship between anxiety and excitation. The combined development of plethysmography and cognitive psychology has greatly contributed to clarify this relationship. Indeed, the relationship between anxiety and sexual arousal appears more complex than originally recognized. Plethysmography directly measures genital vasocongestion at presentation of erotic stimuli and thus permits an objective assessment of sexual arousal in varied circumstances (erotic, anxiety producing, neutral or distracting). In studies using this paradigm, anxiety appears to have a non linear influence on sexual arousal: sometimes it is inhibitory, other times it is facilitative. Articulating the results obtained using plethysmography with the latest development in cognitive sciences, the following hypothesis came to mind: erotophobia could be considered of factor of vulnerability towards cognitive interference. In a sexual situation, erotophobic subjects focus primarily upon danger related information. This could engender a massive irruption of non erotic cues (non relevant task information) in working memory. Therefore, cognitive function available for sexual arousal would be diminished and sexual activity would be impaired. This hypothesis brings light onto the inhibitory effect of anxiety on sexual arousal among dysfunctional subjects. When this cognitive interference is not present, anxiety rather reinforces sexual arousal: either by increasing the focus of attention towards sexual cues or by misinterpreting the physiological reactions induced by the stressful situation as being sexual in origin. [less ▲]

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See detailL’apprentissage procédural chez le jeune enfant : présentation d’un nouvel outil d’évaluation
Lejeune, Caroline ULg; Delcourt, Isabelle; Meulemans, Thierry ULg

Poster (2008)

The authors generally agree that procedural learning abilities play an important role in the child development and that they are present early in childhood. However, few studies have been carried out in ... [more ▼]

The authors generally agree that procedural learning abilities play an important role in the child development and that they are present early in childhood. However, few studies have been carried out in this area because of the difficulty to develop tests specifically designed for the evaluation of these capacities in young children. In this study, we presented a new task aimed to evaluate visuo-motor skill learning in the young child. The purpose of the present study was to explore whether procedural learning abilities are present in the same extent in 4-year as 7- and 10-year-old children. Our sample is composed of 60 children divided into 3 age-groups. The task is composed of 5 blocks of 12 trials during which each subject has to use a reversed mouse of a computer in order to “catch” different toys appearing on the screen; 2 blocks of 12 trials was administered after a 15 minutes delay. Our results show an important difference between the groups for the first block; on the other hand, for the next blocks, the results show an absence of age-related difference between participants in our perceptive-motor skill learning task, confirming the idea according to which procedural learning abilities are efficient early in development (the difference observed during the first block being probably due to the intervention of executive mechanisms). [less ▲]

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See detailSite effects modelling applied to the slope affected by the Suusamyr earthquake (Kyrgyzstan, 1992)
Bourdeau, Céline ULg; Havenith, Hans-Balder ULg

in Engineering Geology (2008), 97

In 1992, a large magnitude earthquake (Ms=7.3) hit the northern part of the Kyrgyz Tien Shan range where it triggered rockslides and many debris slides or flows. One of these mass movements occurred on ... [more ▼]

In 1992, a large magnitude earthquake (Ms=7.3) hit the northern part of the Kyrgyz Tien Shan range where it triggered rockslides and many debris slides or flows. One of these mass movements occurred on the Chet–Korumdy ridge located in the Suusamyr Basin. It consists of a multi-rotational debris slump in its upper part that turned into a debris flow in its lower part. Involving arenitic material overlying silty clays, it has a volume of about 0.5 to 1.106 m3, a maximum thickness of 40mand a run-out of 200 m. The field observations and measurements carried out on this slope suggest that local amplification effects could have contributed to the initiation of the seismic failure. To test this hypothesis in the lack of instrumental evidence of local ground-motion recordings, we conducted a sensitivity study of site effects based on a numerical analysis in the visco-elastic domain with a twodimensional finite difference code. Varying the topography and the geology of the investigated slope, topographic site effects are found to be less important than geological site effects which are controlled by the contrast of impedance between the surface materials and the bedrock. The geometry of the low-velocity surface layer has also an influence on site effects, which is often difficult to be distinguished from pure topographic effects. Considering all modelling results, we conclude that site amplifications alone cannot have triggered the Suusamyr landslide during the 1992 earthquake. The static slope stability analyses done in previous studies revealed that the Suusamyr failure neither can have a purely static origin. Even if the water table is very high within the arenite layer, only a minor failure develops in the lower part of the slope. Therefore, we believe that the triggering of the Suusamyr landslide is a consequence of pore pressure build up in areas characterized by significant ground-motion amplifications. [less ▲]

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See detailIndexation du DFG pour la surface corporelle: mythe et réalité.
Delanaye, Pierre ULg

Conference given outside the academic context (2008)

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