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See detailRecherche-intervention en développement durable
Stassart, Pierre ULg; Mormont, Marc ULg; Pichault, François ULg et al

in Pichault, François (Ed.) La recherche-intervention peut-elle être socialement responsable ? (2008)

Les questions de développement durable sont non seulemenr complexes, mais le caractère crucial de leurs enjeux suppose en outre, de la part des chercheurs en sciences sociales, une approche renouvelée de ... [more ▼]

Les questions de développement durable sont non seulemenr complexes, mais le caractère crucial de leurs enjeux suppose en outre, de la part des chercheurs en sciences sociales, une approche renouvelée de leurs analyses et de leurs interventions. Cette approche engage des processus « multistakeholders » dont la caractéristique est d'impliquer simultanément des acteurs aux caractéristiques hétérogènes qui sont dans notre cas les acteurs de la filière bovine bio. La proposition de recherche-intervention force les chercheurs à clarifier leur relation à l'objet qu'ils étudient et la qualité de leur travail dépend de la qualité et de la légitimité des traductions successives qu'ils opkrent. Ce travail suppose de prendre au sérieux la construction de nouveaux rapports entre science de la nature, recherche technique et action collective. La question de la responsabilité sociale des chercheurs est ancrée dans cette démarche, elle renvoie à une triple dimension éthique. [less ▲]

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See detailRoman road pollution assessed by elemental and lead isotope geochemistry in East Belgium
Renson, Virginie; Fagel, Nathalie ULg; Mattielli, Nadine et al

in Applied Geochemistry (2008), 23(12), 3253-3266

The ability of inorganic geochemistry to record environmental change and especially human impact has been evidenced by several studies across Europe, especially in peat, where it is possible to record the ... [more ▼]

The ability of inorganic geochemistry to record environmental change and especially human impact has been evidenced by several studies across Europe, especially in peat, where it is possible to record the impact of agriculture, mining and other industries. However, despite the numerous investigations on the impact of ancient human activities such as ore mining and smelting, little attention has been paid to geochemistry as a tool to solve problems of palaeopollution in the surroundings of archaeological sites. This paper presents geochemical evidence of the impact of a possible early Roman road built in SE Belgian peatland. Increased Zn and Pb concentrations suggest that Pb-Zn ores were transported on the road, Lead isotope analyses suggest that these ores are locally derived, being compatible with those found in the nearby Pb-Zn ore deposits from East Belgium. Present results provide direct evidence that East Belgian Pb-Zn ores were already being mined during Roman times, i.e. earlier than previously suspected (i.e. 14th century) and that Zn appears to be relatively immobile here. On a broader scale, it also demonstrates that such an early road already had an impact on the environment in terms of metal pollution. This paper enlarges on the range of possibilities offered by geochemistry in the field of geoarchaeology. (C) 2008 Elsevier Ltd. All rights reserved. [less ▲]

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See detailDirect inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication.
Peixoto, Paul ULg; Liu, Yang; Depauw, Sabine et al

in Nucleic Acids Research (2008), 36(10), 3341-53

The development of small molecules to control gene expression could be the spearhead of future-targeted therapeutic approaches in multiple pathologies. Among heterocyclic dications developed with this aim ... [more ▼]

The development of small molecules to control gene expression could be the spearhead of future-targeted therapeutic approaches in multiple pathologies. Among heterocyclic dications developed with this aim, a phenyl-furan-benzimidazole dication DB293 binds AT-rich sites as a monomer and 5'-ATGA sequence as a stacked dimer, both in the minor groove. Here, we used a protein/DNA array approach to evaluate the ability of DB293 to specifically inhibit transcription factors DNA-binding in a single-step, competitive mode. DB293 inhibits two POU-domain transcription factors Pit-1 and Brn-3 but not IRF-1, despite the presence of an ATGA and AT-rich sites within all three consensus sequences. EMSA, DNase I footprinting and surface-plasmon-resonance experiments determined the precise binding site, affinity and stoichiometry of DB293 interaction to the consensus targets. Binding of DB293 occurred as a cooperative dimer on the ATGA part of Brn-3 site but as two monomers on AT-rich sites of IRF-1 sequence. For Pit-1 site, ATGA or AT-rich mutated sequences identified the contribution of both sites for DB293 recognition. In conclusion, DB293 is a strong inhibitor of two POU-domain transcription factors through a cooperative binding to ATGA. These findings are the first to show that heterocyclic dications can inhibit major groove transcription factors and they open the door to the control of transcription factors activity by those compounds. [less ▲]

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See detailMothflies (Diptera : Psychodidae) in hospitals: A guide to their identification and methods for their control
Verheggen, François ULg; Mignon, Jacques ULg; Louis, Josiane ULg et al

in Acta Clinica Belgica (2008), 63(4), 251-255

Repeated observation of "mothflies" at CHU Brugmann (Horta site hospital in Brussels) is not an isolated incident. Many public buildings have been infested by these Diptera of the Psychodidae Family ... [more ▼]

Repeated observation of "mothflies" at CHU Brugmann (Horta site hospital in Brussels) is not an isolated incident. Many public buildings have been infested by these Diptera of the Psychodidae Family. Although the species currently seen in Belgium is not a danger to human health, any infestation should be swiftly eradicated so as to limit the risks of a massive proliferation, source of hygiene problems and of potential bacterial dissemination. A good knowledge of adult and larval biology allows the potential sites of infestation to be quickly identified. The method to be envisaged to solve the problem will combine different approaches such as removing the risk factors (decomposing organic matter), monitoring egg-laying sites, applying caustic soda-based products and possibly treating with insecticide. [less ▲]

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See detailNotaBene RDF Annotation Tool
Mazziotta, Nicolas ULg

Software (2008)

NotaBene RDF Annotation Tool is a wxPython graphical user interface. Its primary purpose is to ease the use of RDF to manually annotate electronic XML editions of left-to-right-written texts. It allows ... [more ▼]

NotaBene RDF Annotation Tool is a wxPython graphical user interface. Its primary purpose is to ease the use of RDF to manually annotate electronic XML editions of left-to-right-written texts. It allows multiple views of the annotated document. [less ▲]

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See detailL'héritage des études sociales de l'objet dans l'action
Melard, François ULg

in Melard, François (Ed.) Écologisation : Objets et concepts intermédiaires (2008)

Ce chapitre introductif vise à présenter une série de perspectives de recherche associées à l'étude des objets et dispositifs socio-techniques selon leurs modes d'engagement dans l'action : l'objet ... [more ▼]

Ce chapitre introductif vise à présenter une série de perspectives de recherche associées à l'étude des objets et dispositifs socio-techniques selon leurs modes d'engagement dans l'action : l'objet "transparent", l'objet "média" ou encore l'objet "médiateur". [less ▲]

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See detailComment je previens...l'endocardite infectieuse: une meilleure hygiene bucco-dentaire plutot qu'une antibioprophylaxie systematique?
Morimont, P.; Frippiat, F.; LANCELLOTTI, Patrizio ULg et al

in Revue Médicale de Liège (2008), 63(11), 640-2

Prophylaxis for infective endocarditis has been recommended on the basis of the supposed pathophysiology of the disease, although no randomised clinical trial has confirmed its efficacy. Bacteraemia ... [more ▼]

Prophylaxis for infective endocarditis has been recommended on the basis of the supposed pathophysiology of the disease, although no randomised clinical trial has confirmed its efficacy. Bacteraemia resulting from daily activities is much more likely to cause infective endocarditis than bacteraemia associated with invasive medical procedures. As a result, recommendations for antibiotic prophylaxis tend now to be severely restricted. [less ▲]

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See detailAn original adaptation of photosynthesis in the marine green alga Ostreococcus.
Cardol, Pierre ULg; Bailleul, Benjamin; Rappaport, Fabrice et al

in Proceedings of the National Academy of Sciences of the United States of America (2008), 105(22), 7881-6

Adaptation of photosynthesis in marine environment has been examined in two strains of the green, picoeukaryote Ostreococcus: OTH95, a surface/high-light strain, and RCC809, a deep-sea/low-light strain ... [more ▼]

Adaptation of photosynthesis in marine environment has been examined in two strains of the green, picoeukaryote Ostreococcus: OTH95, a surface/high-light strain, and RCC809, a deep-sea/low-light strain. Differences between the two strains include changes in the light-harvesting capacity, which is lower in OTH95, and in the photoprotection capacity, which is enhanced in OTH95. Furthermore, RCC809 has a reduced maximum rate of O(2) evolution, which is limited by its decreased photosystem I (PSI) level, a possible adaptation to Fe limitation in the open oceans. This decrease is, however, accompanied by a substantial rerouting of the electron flow to establish an H(2)O-to-H(2)O cycle, involving PSII and a potential plastid plastoquinol terminal oxidase. This pathway bypasses electron transfer through the cytochrome b(6)f complex and allows the pumping of "extra" protons into the thylakoid lumen. By promoting the generation of a large DeltapH, it facilitates ATP synthesis and nonphotochemical quenching when RCC809 cells are exposed to excess excitation energy. We propose that the diversion of electrons to oxygen downstream of PSII, but before PSI, reflects a common and compulsory strategy in marine phytoplankton to bypass the constraints imposed by light and/or nutrient limitation and allow successful colonization of the open-ocean marine environment. [less ▲]

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See detailLe point sur le diagnostic de l’aspergillose naso-sinusale chez le chien.
Billen, Frédéric ULg; Clercx, Cécile ULg; Peeters, Dominique ULg

in Annales de Médecine Vétérinaire (2008), 152(2)

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See detailCushing et syndrome métabolique équin
Amory, Hélène ULg

in Proceedings of the 25th Annual Congress of the Belgian Equine Practitioners Society (BEPS) (2008)

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See detailEffects of surgery on ischaemic mitral regurgitation: a prospective multicentre registry (SIMRAM registry).
Lancellotti, Patrizio ULg; Donal, Erwan; Cosyns, Bernard et al

in European Journal of Echocardiography (2008), 9(1), 26-30

AIMS: Functional ischaemic mitral regurgitation (IMR) is common in patients with ischaemic left ventricular dysfunction undergoing coronary artery bypass surgery. Although the presence of IMR negatively ... [more ▼]

AIMS: Functional ischaemic mitral regurgitation (IMR) is common in patients with ischaemic left ventricular dysfunction undergoing coronary artery bypass surgery. Although the presence of IMR negatively affects prognosis, the additional benefit of valve repair is debated, particularly with mild IMR at rest. Exercise echocardiography may help identify a subset of patients at higher risk of cardiovascular events by revealing the dynamic component of IMR. METHODS: A large prospective, multicentre, non-randomized registry is designed to evaluate the effects of surgery on IMR at rest and on its dynamic component at exercise (z). SIMRAM will enrol approximately 550 patients with IMR in up to 17 centres with clinical and exercise follow-up for 1 year. Three sets of outcomes will be prospectively assessed and several hypotheses will be tested including determinants of adverse outcome and progressive left ventricular remodeling, efficacy of treatment and role of ischaemia on the dynamic consequences of IMR. Enrolment began in November 2006 and is expected to end by early 2008. [less ▲]

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See detailSecond-order Plastic-hinge Analysis of 3D Steel Frames including Strain Hardening Effects
Hoang, Van Long ULg; Nguyen, Dang Hung

in Engineering Structures (2008), 30

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See detailBase de données sur les prix artistiques dans l'entre-deux-guerres au Québec
Dozo, Björn-Olav ULg; Lapointe, Olivier

Textual, factual or bibliographical database (2008)

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See detailDébats belges pour une politique migratoire. Mapping des acteurs
Perrin, Nathalie ULg; Stockmans, Pieter

Book published by Fondation Roi Baudouin (2008)

Cette publication propose un inventaire des principaux acteurs qui contribuent ou peuvent contribuer à définir une politique migratoire pour la Belgique ; elle fait aussi le point sur leurs prises de ... [more ▼]

Cette publication propose un inventaire des principaux acteurs qui contribuent ou peuvent contribuer à définir une politique migratoire pour la Belgique ; elle fait aussi le point sur leurs prises de position récentes. Quel est par exemple le point de vue de la FGTB sur une régularisation ? Que pense la FEB d’une nouvelle migration économique ? Que dit le Conseil des Femmes sur l’accueil des primo-arrivants ? Et bien d’autres encore. [less ▲]

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See detailThe hallucinating brain: A review of structural and functional neuroimaging studies of hallucinations
Allen, P.; Laroi, Frank ULg; McGuire, P. K. et al

in Neuroscience & Biobehavioral Reviews (2008), 32(1), 175-191

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See detailDetection of antigenic heterogeneity in feline coronavirus nucleocapsid in feline pyogranulomatous meningoencephalitis.
Poncelet, Luc; Coppens, Angélique; Peeters, Dominique ULg et al

in Veterinary Pathology (2008), 45(2)

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See detailDifferences and similarities in the sensory and cognitive signatures of voice-hearing, intrusions and thoughts
Moritz, S.; Laroi, Frank ULg

in Schizophrenia Research (2008), 102(1-3), 96-107

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See detailAlternative photosynthetic electron flow to oxygen in marine Synechococcus.
Bailey, Shaun; Melis, Anastasios; Mackey, Katherine R M et al

in Biochimica et Biophysica Acta (2008), 1777(3), 269-76

Cyanobacteria dominate the world's oceans where iron is often barely detectable. One manifestation of low iron adaptation in the oligotrophic marine environment is a decrease in levels of iron-rich ... [more ▼]

Cyanobacteria dominate the world's oceans where iron is often barely detectable. One manifestation of low iron adaptation in the oligotrophic marine environment is a decrease in levels of iron-rich photosynthetic components, including the reaction center of photosystem I and the cytochrome b6f complex [R.F. Strzepek and P.J. Harrison, Photosynthetic architecture differs in coastal and oceanic diatoms, Nature 431 (2004) 689-692.]. These thylakoid membrane components have well characterised roles in linear and cyclic photosynthetic electron transport and their low abundance creates potential impediments to photosynthetic function. Here we show that the marine cyanobacterium Synechococcus WH8102 exhibits significant alternative electron flow to O2, a potential adaptation to the low iron environment in oligotrophic oceans. This alternative electron flow appears to extract electrons from the intersystem electron transport chain, prior to photosystem I. Inhibitor studies demonstrate that a propyl gallate-sensitive oxidase mediates this flow of electrons to oxygen, which in turn alleviates excessive photosystem II excitation pressure that can often occur even at relatively low irradiance. These findings are also discussed in the context of satisfying the energetic requirements of the cell when photosystem I abundance is low. [less ▲]

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See detailÉco-éthologie d’une population de vipères péliades (Vipera b. berus L.) dans une région de bocage du sud-ouest de la Belgique
Graitson, Eric ULg

in Bulletin de la Société Herpétologique de France (2008), 128

the preference of adders for different linear elements of the ‘bocage’, a farmland landscape crisscrossed by hedges, was studied during 2.5 years in south-West Belgium. Most individuals occurred in South ... [more ▼]

the preference of adders for different linear elements of the ‘bocage’, a farmland landscape crisscrossed by hedges, was studied during 2.5 years in south-West Belgium. Most individuals occurred in South-facing woody hedges between the autumn and the beginning of spring. During the mating period, by contrast, most individuals tended to shift of habitat and favoured 1 to 2 m wide grassy hedges with a limited shrub cover and a north-south orientation. Mating females especially favoured this latter habitat, probably because of their specific micro-climatic conditions, including a higher insulation. A few individuals, however, remained in the same habitat all year round. The identification of individuals, which was performed on the basis of features including body and head color patterns, but not on individual clipping, proved to be difficult owing to the high density of individuals. Linear elements in the form of grassy hedges, not very space-consuming, can shelter very high densities of snakes. in the context of a sharp decrease of the bocage landscape, the conservation of common European vipers relies on the maintenance of such linear landscape elements as grassy and shrubby hedges, which can be enhanced by the implementation of recent measures aiming at restoring extensive agricultural systems. [less ▲]

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