References of "2008"
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See detailTâche de Rappel Libre/Rappel Indicé à 16 items (RL/RI-16)
Adam, Stéphane ULg

in Hugonot-Diener, L.; Barbeau, Emmanuel; Michel, Bernard (Eds.) et al GREMOIRE: Tests et échelles de la maladie d'Alzheimer et des syndromes apparentés (2008)

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See detailMultidisciplinary approach to reconstruct the Belgian Frasnian platform - facies, carbon isotopes and magnetic susceptibility
Da Silva, Anne-Christine ULg; Mabille, Cedric; Boulvain, Frédéric ULg

in . SDGG, Heft 58 – Abstract Volume – 26th IAS Regional Meeting/SEPM-CES SEDIMENT 2008 (2008)

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See detailEvaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system.
Bruyère, Olivier ULg; Burlet, Nansa; Delmas, Pierre D et al

in BMC Musculoskeletal Disorders (2008), 9

BACKGROUND: Symptomatic slow-acting drugs (SYSADOA) have been largely studied over the last decade. The objective of this study is to prepare a document providing recommendations for the use of SYSADOA in ... [more ▼]

BACKGROUND: Symptomatic slow-acting drugs (SYSADOA) have been largely studied over the last decade. The objective of this study is to prepare a document providing recommendations for the use of SYSADOA in osteoarthritis (OA). METHODS: The following interventions were taken into consideration: avocado/soybean unsaponifiables, chondroitin sulfate, diacereine, glucosamine sulfate, hyaluronic acid, oral calcitonin, risedronate, strontium ranelate. Recommendations were based on the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. The GRADE system is based on a sequential assessment of the quality of evidence, followed by assessment of the balance between benefits versus downsides and subsequent judgment about the strength of recommendations. RESULTS: Chondroitin sulfate, diacereine, glucosamine sulfate, avocado/soybean unsaponifiables and hyaluronic acid have demonstrated pain reduction and physical function improvement with very low toxicity, with moderate to high quality evidence. Even if pre-clinical data and some preliminary in vivo studies have suggested that oral calcitonin and strontium ranelate could be of potential interest in OA, additional well-designed studies are needed. CONCLUSION: In the benefit/risk ratio, the use of chondroitin sulfate, diacereine, glucosamine sulfate, avocado/soybean unsaponifiables and hyaluronic acid could be of potential interest for the symptomatic management of OA. [less ▲]

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See detailComputational Study Of Colipase Interaction With Lipid Droplets And Bile Salt Micelles
Kerfelec, Brigitte; Allouche, Maya; Colin, Damien et al

in Proteins-Structure Function and Bioinformatics (2008), 73(4), 828-38

Colipase is a key element in the lipase-catalyzed hydrolysis of dietary lipids. Although devoid of enzymatic activity, colipase promotes the pancreatic lipase activity in physiological intestinal ... [more ▼]

Colipase is a key element in the lipase-catalyzed hydrolysis of dietary lipids. Although devoid of enzymatic activity, colipase promotes the pancreatic lipase activity in physiological intestinal conditions by anchoring the enzyme at the surface of lipid droplets. Analysis of structures of NMR colipase models and simulations of their interactions with various lipid aggregates, lipid droplet, and bile salt micelle, were carried out to determine and to map the lipid binding sites on colipase. We show that the micelle and the oil droplet bind to the same side of colipase 3D structure, mainly the hydrophobic fingers. Moreover, it appears that, although colipase has a single direction of interaction with a lipid interface, it does not bind in a specific way but rather oscillates between different positions. Indeed, different NMR models of colipase insert different fragments of sequence in the interface, either simultaneously or independently. This supports the idea that colipase finger plasticity may be crucial to adapt the lipase activity to different lipid aggregates. [less ▲]

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See detailEffect of zoledronic acid (single 5 mg infusion) on lumbar spine bone mineral density versus oral risedronate (5 mg/day) over one year in subgroups of patients receiving glucocorticoid therapy
Roux, C.; Reid, D.; Devogelaer, J. P. et al

in Osteoporosis International (2008), 19(S2), 248-249

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See detailEffect of different treatment protocols on ovulation and pregnancy rate in dairy cattle.
Repasy, A.; Melo de Sousa, Noelita ULg; Beckers, Jean-François ULg et al

in Magyar Allatorvosok Lapja = Hungarian Veterinary Journal (2008), (Suppl II), 314

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See detailSite effects modelling applied to the slope affected by the Suusamyr earthquake (Kyrgyzstan, 1992)
Bourdeau, Céline ULg; Havenith, Hans-Balder ULg

in Engineering Geology (2008), 97

In 1992, a large magnitude earthquake (Ms=7.3) hit the northern part of the Kyrgyz Tien Shan range where it triggered rockslides and many debris slides or flows. One of these mass movements occurred on ... [more ▼]

In 1992, a large magnitude earthquake (Ms=7.3) hit the northern part of the Kyrgyz Tien Shan range where it triggered rockslides and many debris slides or flows. One of these mass movements occurred on the Chet–Korumdy ridge located in the Suusamyr Basin. It consists of a multi-rotational debris slump in its upper part that turned into a debris flow in its lower part. Involving arenitic material overlying silty clays, it has a volume of about 0.5 to 1.106 m3, a maximum thickness of 40mand a run-out of 200 m. The field observations and measurements carried out on this slope suggest that local amplification effects could have contributed to the initiation of the seismic failure. To test this hypothesis in the lack of instrumental evidence of local ground-motion recordings, we conducted a sensitivity study of site effects based on a numerical analysis in the visco-elastic domain with a twodimensional finite difference code. Varying the topography and the geology of the investigated slope, topographic site effects are found to be less important than geological site effects which are controlled by the contrast of impedance between the surface materials and the bedrock. The geometry of the low-velocity surface layer has also an influence on site effects, which is often difficult to be distinguished from pure topographic effects. Considering all modelling results, we conclude that site amplifications alone cannot have triggered the Suusamyr landslide during the 1992 earthquake. The static slope stability analyses done in previous studies revealed that the Suusamyr failure neither can have a purely static origin. Even if the water table is very high within the arenite layer, only a minor failure develops in the lower part of the slope. Therefore, we believe that the triggering of the Suusamyr landslide is a consequence of pore pressure build up in areas characterized by significant ground-motion amplifications. [less ▲]

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See detailRenforcement structurel de la capacité de gestion des ressources en eau pour l'agriculture dans le bassin du Kou (Burkina Faso): Rapport Technique 2 (2007-2008)
Wellens, Joost ULg; Tychon, Bernard ULg; Traore, Farid et al

Report (2008)

Le bassin du Kou, situé dans le sud-ouest du Burkina Faso, est depuis quelques décennies le théâtre de différentes formes de conflits liés à toute une série de problèmes que l’on rencontre généralement ... [more ▼]

Le bassin du Kou, situé dans le sud-ouest du Burkina Faso, est depuis quelques décennies le théâtre de différentes formes de conflits liés à toute une série de problèmes que l’on rencontre généralement dans des zones irriguées. Dans le bassin du Kou, les aménagements hydroagricoles recensés couvrent une superficie totale de près de 3.200 ha. Il s’agit pour l’essentiel de périmètres privés formant la ceinture maraîchère, horticole et fruitière de Bobo-Dioulasso et d’un grand périmètre de 1.200 ha réalisé par l’Etat à Bama et spécialisé dans la production du riz. Outre l’abondance en eau liée à la présence de sources importantes, d’une nappe phréatique facilement exploitable, d’un cours d’eau pérenne et un hivernage à caractère sub-humide, la plupart des utilisateurs d’eau se retrouvent régulièrement en pénurie d’eau à cause d’une augmentation de la population et d’une intensification de l’agriculture irriguée. Ceci conduit les gestionnaires du bassin à rechercher des outils de contrôle et de suivi. [less ▲]

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See detailThe inside-out trans-obturator sling: a novel surgical technique for the treatment of male urinary incontinence
de Leval, Jean ULg; Waltregny, David ULg

in European Urology (2008), 54(5), 1051-65

OBJECTIVES: To describe a new sling procedure for treating stress urinary incontinence (SUI) after radical prostatectomy (RP) and prospectively evaluate its short-term safety and efficacy. METHODS: The ... [more ▼]

OBJECTIVES: To describe a new sling procedure for treating stress urinary incontinence (SUI) after radical prostatectomy (RP) and prospectively evaluate its short-term safety and efficacy. METHODS: The sling technique uses specific instruments and a polypropylene mesh with two arms that are passed inside to outside through the obturator foramens, pulled for compressing the bulbar urethra upward, and tied to each other across the midline. Patients with detrusor overactivity were excluded. Baseline and follow-up evaluations included uroflowmetry and continence and quality of life (QoL) questionnaires. Cure was defined by no pad use and improvement by a number of pads/d <or=2 and reduced by at least 50%. Complications were recorded. RESULTS: From April 2006 through February 2007, 20 consecutive patients suffering from post-RP SUI underwent the sling procedure using the same operative protocol. Preoperatively, 3 (15%), 11 (55%), and 6 (25%) patients were using 2, 3-5, and >5pads/d, respectively. The procedure was preceded by an endoscopic urethrotomy in four patients. No perioperative complication was noted; three patients required suprapubic catheterization. At 6 mo, nine (45%) patients were cured and eight others (40%) were improved (1pad/d). QoL was significantly enhanced and 80% of patients were moderately to completely satisfied with the procedure. Preoperative and postoperative maximum flow rate and postvoid residual values were not statistically different. No sling infection, urethra erosion, persistent pain, or neurologic complications were observed. CONCLUSIONS: The inside-out trans-obturator sling procedure appears to be safe and efficient at short term. Further studies are warranted to determine long-term outcome. [less ▲]

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See detailBulletin de la Commission royale pour la publication des Anciennes Lois et Ordonnances de Belgique
Marchandisse, Alain ULg

Book published by Ministère de la Justice (2008)

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See detailLa neurogenese adulte ou l'histoire d'un dogme qui s'ecroule.
Pirotte, Dorothée ULg; Rogister, Bernard ULg

in Revue Médicale de Liège (2008), 63(5-6), 245-50

The history of sciences is characterized by major discoveries, but also by challenges of theories or dogma previously established and accepted by everybody. One of the recent examples illustrating such a ... [more ▼]

The history of sciences is characterized by major discoveries, but also by challenges of theories or dogma previously established and accepted by everybody. One of the recent examples illustrating such a questioning relates to the demonstration of the persistence of a cerebral neurogenesis in the adult brain, including in human. This adult neurogenesis is however limited, both in space (it concerns only the subventricular zone and the gyrus dentatus in the hippocampus) and the type of newly-formed neurons (interneurones which most of them are GABAergic and present respectively in the olfactive bulb and CA1 area of the hippocampus). Moreover, this neurogenesis does not seem to be recruited after a brain lesion, a situation which explains why functional recovery when it is observed remains a consequence of brain plasticity. We thus legitimately address the question about the physiological role of this adult brain neurogenesis as well as a possible implication in the aetiology of various neurological disorders, like the neurodegenerative diseases or epilepsy, but also in psychiatric diseases like depression. [less ▲]

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See detailTheoretical Understanding of Targeted Energy Transfers for Suppressing Aeroelastic Instabilities in a Nonlinear Aeroelastic Test Apparatus
Lee, Young S.; McFarland, D. Michael; Kerschen, Gaëtan ULg et al

in 45th Technical Meeting of the Society of Engineering Science, Urbana Champaign, 2008 (2008)

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See detailVapor phase doping: an atomic layer deposition approach to n-type doping in classical chemical vapor deposition epitaxy
Takeuchi, Shotaro; Nguyen, Ngoc Duy ULg; Leys, Frederik et al

Conference (2008)

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See detailMaternal transfer of trace elements in leatherback turtles (Dermochelys coriacea) of French Guiana
Guirlet, Elodie ULg; Das, Krishna ULg; Girondot, Marc

in Aquatic Toxicology (2008), 88

In sea turtles, parental investment is limited to the nutrients and energy invested in eggs that will support embryonic development. Leatherback females have the largest clutches with the biggest eggs of ... [more ▼]

In sea turtles, parental investment is limited to the nutrients and energy invested in eggs that will support embryonic development. Leatherback females have the largest clutches with the biggest eggs of the sea turtles and the highest reproductive output in reptiles. The migration between foraging sites and nesting beaches also represents high energy expenditure. The toxicokinetic of pollutants in the tissues is thus expected to vary during those periods but there is a lack of information in reptiles. Concentrations of essential (Copper, Zinc, Selenium) and non-essentials elements (Cadmium, Lead, Mercury) were determined in blood (n = 78) and eggs (n = 76) of 46 free-ranging leatherback females collected in French Guiana. Maternal transfer to eggs and relationships between blood and eggs concentrations during the nesting seasonwere investigated. All trace elementswere detectable in both tissues. Levels of toxic metals were lower than essential elements likely due to the high pelagic nature of leatherbacks that seems to limit exposure to toxic elements. Significant relationships between blood and egg concentrations were observed for Se and Cd. Se could have an important role in embryonic development of leatherback turtles and Cd transfer could be linked to similar carrier proteins as Se. Finally, as multiple clutcheswere sampled from each female, trends in trace elements were investigated along the nesting season. No change was observed in eggs but changeswere recorded in blood concentrations of Cu. Cu level decreased while blood Pb levels increased through the nesting season. The high demand on the body during the breeding season seems to affect blood Cu concentrations. Calcium requirement for egg production with concomitant Pb mobilization could explain the increase in blood Pb concentrations along the nesting season. [less ▲]

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See detailRebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors.
Marminon, Christelle; Anizon, Fabrice; Moreau, Pascale et al

in Molecular Pharmacology (2008), 74(6), 1620-9

Rebeccamycin is an indolocarbazole class inhibitor of topoisomerase I. In the course of structure-activity relationship studies on rebeccamycin derivatives, we have synthesized analogs with the sugar ... [more ▼]

Rebeccamycin is an indolocarbazole class inhibitor of topoisomerase I. In the course of structure-activity relationship studies on rebeccamycin derivatives, we have synthesized analogs with the sugar moiety attached to either one or both indole nitrogens. Some analogs, especially those with substitutions at the 6' position of the carbohydrate moiety, exhibit potent inhibitory activity toward checkpoint kinase 1 (Chk1), a kinase that has a major role in the G(2)/M checkpoint in response to DNA damage. Some of these compounds retained a genotoxic activity either through intercalation into the DNA and/or by topoisomerase I-mediated DNA cleavage. We explored the structure-activity relationship between these compounds and their multiple targets. These rebeccamycin derivatives represent a novel class of potential antitumor agents that have a dual effect and might selectively induce the death of cancer cells. [less ▲]

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See detailCulicoides trapping with Rothamsted suction traps before and during the bluetongue epidemic of 2006 in Belgium.
Fassotte, C.; Delecolle, J. C.; Cors, R. et al

in Preventive Veterinary Medicine (2008), 87(1-2), 74-83

The collection of biting midges was taking place some months before the first bluetongue outbreak in Belgium in August 2006. The Walloon Agricultural Research Centre had been monitoring aphid populations ... [more ▼]

The collection of biting midges was taking place some months before the first bluetongue outbreak in Belgium in August 2006. The Walloon Agricultural Research Centre had been monitoring aphid populations at two sites annually in Belgium (Gembloux and Libramont), using two stationary '12-m' Rothamsted suction traps. For the Gembloux trap, collections of insects captured daily from 11 May 2006 onwards were already available at the time of the outbreak. An examination of these samples revealed the presence of Culicoides, some species of which are considered as potential vectors of the bluetongue virus (BTV). The trapping was therefore extended beyond the normal aphid activity period and the Culicoides captured were identified to species level. From 11 May to 31 December 2006, the Gembloux trap caught 664 Culicoides specimens belonging to 19 species comprising known BTV-vectors. The second trap, at Libramont, was reactivated from 12 September to 13 October and caught 97 specimens belonging to nine species, all of which had been found at the Gembloux site. Among the 19 species identified, four were new to Belgian fauna: Culicoides achrayi, C. deltus, C. lupicaris and C. newsteadi. This paper examines the overall phenology and the physiological status of Culicoides in 2006 before and during the bluetongue epidemic. It discusses the potential of the Rothamsted suction trap to monitor Culicoides. [less ▲]

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See detailEvidence of a type 1/type 2 dichotomy in the correlation between quasar optical polarization and host-galaxy/extended emission position angles
Borguet, Benoît ULg; Hutsemekers, Damien ULg; Letawe, Géraldine ULg et al

in Astronomy and Astrophysics (2008), 478

Aims.For Seyfert galaxies, the AGN unification model provides a simple and well-established explanation of the type 1/type 2 dichotomy through orientation-based effects. The generalization of this ... [more ▼]

Aims.For Seyfert galaxies, the AGN unification model provides a simple and well-established explanation of the type 1/type 2 dichotomy through orientation-based effects. The generalization of this unification model to the higher luminosity AGNs that quasars are remains a key question. The recent detection of type 2 radio-quiet quasars seems to support such an extension. We propose a further test of this scenario. Methods: On the basis of a compilation of quasar host-galaxy position angles consisting of previously published data and of new measurements performed using HST Archive images, we investigate the possible existence of a correlation between the linear polarization position angle and the host-galaxy/extended emission position angle of quasars. Results: We find that the orientation of the rest-frame UV/blue extended emission is correlated to the direction of the quasar polarization. For type 1 quasars, the polarization is aligned with the extended UV/blue emission, while these two quantities are perpendicular in type 2 objects. This result is independent of the quasar radio loudness. We interpret this (anti-)alignment effect in terms of scattering in a two-component polar+equatorial model that applies to both type 1 and type 2 objects. Moreover, the orientation of the polarization -and then of the UV/blue scattered light- does not appear correlated to the major axis of the stellar component of the host-galaxy measured from near-IR images. [less ▲]

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See detail‘De exploitatie van intellectuele eigendom via licentieverlening – Capita selecta’
Vanbrabant, Bernard ULg; Van Couter, Yves

in La propriété intellectuelle omniprésente dans l'entreprise (2008)

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See detailLes MRSA et la peau. Nouveaux visages des HAMRSA, des CAMRSA et des PAMRSA.
Devillers, Céline; Pierard-Franchimont, Claudine ULg; Henry, Frédérique ULg et al

in Skin (2008), 11

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