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See detailA thermo-hydro-mechanical stress-strain framework for modelling the performance of clay barriers in deep geological repositories for radioactive waste
Laloui, Lyesse; François, Bertrand ULg; Nuth, Mathieu et al

in 1st European Conf. on Unsaturated Soils (2008)

Assessing the performance of deep geological repositories for heat-generating radioactive waste requires reliable predictions of the Thermo-Hydro-Mechanical (THM) behaviour of the clay barriers (the ... [more ▼]

Assessing the performance of deep geological repositories for heat-generating radioactive waste requires reliable predictions of the Thermo-Hydro-Mechanical (THM) behaviour of the clay barriers (the buffer material as well as the host rock/clay). This represents an important element of the waste isolation system. In order to provide reasonable assurance that clay barriers will ensure nuclear waste isolation, it is essential to understand their behaviour under a variety of environmental conditions. The phenomena involved are complex, and adequately understanding the constitutive behaviour of clays and modelling their evolution is challenging. The stress-strain material behaviours that need to be understood and modelled include drying and wetting in nonisothermal conditions and heating-cooling in non-saturated conditions. Other aspects should be considered, such as drying induced cracks and the role of the material structure and its multi-porosity. The difficulty of some of these tasks is increased by the fact that some effects are coupled. The fundamental behaviours of clayey materials under the considered THM conditions are first identified and highlighted for deep repository experiments. We then propose a mechanical stress-strain constitutive framework to model the behaviour of clay barriers. This includes aspects such as the thermo-plastic behaviour of saturated and unsaturated materials. In the third part, we show that the proposed framework allows us to experimentally explain observed behaviours and to predict the THM behaviour of clay barriers. [less ▲]

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See detailAn original adaptation of photosynthesis in the marine green alga Ostreococcus.
Cardol, Pierre ULg; Bailleul, Benjamin; Rappaport, Fabrice et al

in Proceedings of the National Academy of Sciences of the United States of America (2008), 105(22), 7881-6

Adaptation of photosynthesis in marine environment has been examined in two strains of the green, picoeukaryote Ostreococcus: OTH95, a surface/high-light strain, and RCC809, a deep-sea/low-light strain ... [more ▼]

Adaptation of photosynthesis in marine environment has been examined in two strains of the green, picoeukaryote Ostreococcus: OTH95, a surface/high-light strain, and RCC809, a deep-sea/low-light strain. Differences between the two strains include changes in the light-harvesting capacity, which is lower in OTH95, and in the photoprotection capacity, which is enhanced in OTH95. Furthermore, RCC809 has a reduced maximum rate of O(2) evolution, which is limited by its decreased photosystem I (PSI) level, a possible adaptation to Fe limitation in the open oceans. This decrease is, however, accompanied by a substantial rerouting of the electron flow to establish an H(2)O-to-H(2)O cycle, involving PSII and a potential plastid plastoquinol terminal oxidase. This pathway bypasses electron transfer through the cytochrome b(6)f complex and allows the pumping of "extra" protons into the thylakoid lumen. By promoting the generation of a large DeltapH, it facilitates ATP synthesis and nonphotochemical quenching when RCC809 cells are exposed to excess excitation energy. We propose that the diversion of electrons to oxygen downstream of PSII, but before PSI, reflects a common and compulsory strategy in marine phytoplankton to bypass the constraints imposed by light and/or nutrient limitation and allow successful colonization of the open-ocean marine environment. [less ▲]

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See detailAtypical myopathy: new insights into the pathophysiology, prevention and management of the condition
Van Galen, Gaby ULg; Serteyn, Didier ULg; Amory, Hélène ULg et al

in Equine Veterinary Education (2008), 20(5), 234-238

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See detailComment je traite... Une acné par isotretinoine.
Pierard, Claudine ULg; Nikkels, Arjen ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2008), 63(3), 115-8

Acne benefits from a series of treatments. The introduction of isotretinoin was a therapeutic breakthrough which considerably improved both the evolution and the prognosis of the disease. Indications of ... [more ▼]

Acne benefits from a series of treatments. The introduction of isotretinoin was a therapeutic breakthrough which considerably improved both the evolution and the prognosis of the disease. Indications of this retinoid kept changing over the past twenty years. New clinical conditions emerged including the management of disease recurrences. The daily dosages must be selected according to the type of acne, the gender of the patient and the pharmaco-economical implications. Teratogenicity must never be neglected as it represents the dreadful adverse event of the drug. A European Directive currently marks out the way to use this retinoid. [less ▲]

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See detailProgressive encephalopathy in a child with cerebral folate deficiency syndrome.
Bonkowsky, Joshua L; RAMAEKERS, Vincent ULg; Quadros, Edward V et al

in Journal of Child Neurology (2008), 23(12), 1460-3

Cerebral folate deficiency syndrome, a recently recognized cause of developmental delay, regression, and seizures, is associated with autoantibodies against folate receptors. A female child with ... [more ▼]

Cerebral folate deficiency syndrome, a recently recognized cause of developmental delay, regression, and seizures, is associated with autoantibodies against folate receptors. A female child with developmental delay and a history of seizures who presented with seizures and unexplained coma is reported. Extensive testing to evaluate the patient's coma and subsequent developmental regression were unrevealing until the results of her cerebrospinal fluid neurotransmitter analysis returned. These showed low levels of methyltetrahydrofolate, the active metabolite of folate in the cerebrospinal fluid; subsequently, elevated titers of autoantibodies against folate receptors were found. Despite treatment with folinic acid, she developed intractable epilepsy and severe developmental delay. [less ▲]

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See detailDer Sturz ins Leere: Die Dämonie von Verlassenheit und Fremde in den Erzählungen Stefan Zweigs
Küpper, Achim ULg

in Birk, Matjaž; Eicher, Thomas (Eds.) Stefan Zweig und das Dämonische (2008)

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See detailThe Early Devonian plants from the Ancenis Basin (Armorican Massif, France): one century later...
Strullu-Derrien, Marie-Christine; Gerrienne, Philippe ULg

Conference (2008)

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See detailRisque à long terme de survenue d'une fracture ostéoporotique en Belgique.
Hiligsmann, Mickaël ULg; Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Revue Médicale de Liège (2008), 63(7-8), 480-487

This work has been realised to estimate the lifetime risk of osteoporotic fracture for Belgian men and women aged 50 and 60 years. Estimates were based on a microsimulation Markov model. They take account ... [more ▼]

This work has been realised to estimate the lifetime risk of osteoporotic fracture for Belgian men and women aged 50 and 60 years. Estimates were based on a microsimulation Markov model. They take account of the incidence of fracture as well as of life expectancy. Several approaches have been taken to model life expectancy. Our estimates also take account of future mortality reductions based on official estimates and secular trends in life expectancy. Lifetime risk of osteoporotic population (bone mineral density below -2.5 T-score) was also estimated. Lifetime risk of hip fracture and any major osteoporotic fracture (hip, clinical vertebral or wrist) were 20.5% and 39% respectively for women aged 60 years. Corresponding values for men were 7.9% and 14.8% and for osteoporotic women 32.3% and 53.4%. Our lifetime risk estimates re-emphasize that osteoporosis is a major public health problem and that its societal burden is likely to increase due to demographic changes. [less ▲]

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See detailEvidence for neo-generation of T cells by the thymus after non-myeloablative conditioning.
Castermans, Emilie ULg; Baron, Frédéric ULg; Willems, Evelyne ULg et al

in Haematologica (2008), 93(2), 240-7

BACKGROUND: Background and objective. We investigated immune recovery in 50 patients given either unmanipulated or CD8-depleted allogeneic peripheral blood stem cells after non-myeloablative conditioning ... [more ▼]

BACKGROUND: Background and objective. We investigated immune recovery in 50 patients given either unmanipulated or CD8-depleted allogeneic peripheral blood stem cells after non-myeloablative conditioning. DESIGN AND METHODS: Fifty patients were randomized to receive either CD8-depleted (n=22) or non-manipulated (n=28) peripheral blood stem cells. The median patients age was 57 (range 36-69) years. The conditioning regimen consisted of 2 Gy total body irradiation with or without added fludarabine. Twenty patients received grafts from related donors, 14 from 10/10 HLA-allele matched unrelated donors, and 16 from HLA-mismatched unrelated donors. Graft-versus-host disease pro-phylaxis consisted of mycophenolate mofetil and cyclosporine. Immune recovery during the first year after hematopoietic cell transplantation was assessed by flow cytometry phenotyping, analyses of the diversity of the TCRBV repertoire, and quantification of signal-joint T-cell receptor excision circles (sjTREC). RESULTS: CD8-depletion of the graft reduced the recovery of CD8(+) T-cell counts in the first 6 months following transplantation (p<0.0001) but had no significant impact on the restoration of other T-cell subsets. Both sjTREC concentration and CD3(+) T-cell counts increased significantly between day 100 and 365 (p=0.010 and p=0.0488, respectively) demonstrating neo-production of T cells by the thymus. Factors associated with high sjTREC concentration 1 year after transplantation included an HLA-matched unrelated donor (p=0.029), a high content of T cells in the graft (p=0.002), and the absence of chronic graft-versus-host disease (p<0.0001). CONCLUSIONS: Our data suggest that while immune recovery is mainly driven by peripheral expansion of the graft-contained mature T cells during the first months after non-myeloablative transplantation, T-cell neo-generation by the thymus plays an important role in long term immune reconstitution in transplanted patients. [less ▲]

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See detailcompte rendu de : Graham ANDERSON, Folktale as a Source of Graeco-Roman Fiction. The Origin of Popular Narrative
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2008), 77

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See detailColossal positive magnetoresistance in a doped nearly magnetic semiconductor
Hu, Rongwei; Thomas, K. J.; Lee, Y. et al

in Physical Review B (2008), 77(8),

We report on a positive colossal magnetoresistance (MR) induced by metallization of FeSb2, a nearly magnetic or "Kondo" semiconductor with 3d ions. We discuss the contribution of orbital MR and quantum ... [more ▼]

We report on a positive colossal magnetoresistance (MR) induced by metallization of FeSb2, a nearly magnetic or "Kondo" semiconductor with 3d ions. We discuss the contribution of orbital MR and quantum interference to the enhanced magnetic field response of electrical resistivity. [less ▲]

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See detailNonmyeloablative Transplantation
Baron, Frédéric ULg; Sandmaier, Brenda

in Hematopoietic Stem Cell Transplantation (2008)

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See detailVector monitoring at Belgian outbreak sites during the bluetongue epidemic of 2006.
De Deken, G.; Madder, M.; Deblauwe, I. et al

in Preventive Veterinary Medicine (2008), 87(1-2), 64-73

In response to the first bluetongue outbreak in Belgium a monitoring programme was started at the end of August 2006 to identify possible vectors transmitting the disease. Black light traps were deployed ... [more ▼]

In response to the first bluetongue outbreak in Belgium a monitoring programme was started at the end of August 2006 to identify possible vectors transmitting the disease. Black light traps were deployed at 36 outbreak sites and captured 1959 Culicoides specimens belonging to 16 different species. Eighty four percent of the biting midges captured belonged to the C. obsoletus complex, among them C. obsoletus s.s., C. dewulfi and C. scoticus, three suspected bluetongue vectors. The Veterinary and Agrochemical Research Centre detected viral RNA in pools of individuals belonging to this complex. Culicoides pulicaris, a potential bluetongue vector in Italy, should yet not be excluded as a possible vector in Belgium as this species was frequently found around outbreak sites, notwithstanding this species is not easily captured with the trapping techniques used during this survey. [less ▲]

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See detailMeasuring the effect of amantadine in chronic anoxic minimally conscious state.
Schnakers, Caroline ULg; Hustinx, Roland ULg; Vandewalle, Gilles ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (2008), 79(2), 225-7

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See detailCarbon and Nitrogen Isotopic Ratios in Comets
Jehin, Emmanuel ULg; Manfroid, Jean ULg; Hutsemekers, Damien ULg et al

in LPI contribution 1405 (2008)

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See detailMicrolensing to probe the quasar structure: spectrophotometry of Q2237+0305 and of J1131-1231
Sluse, Dominique; Eigenbrod, A.; Courbin, F. et al

in Kerins, E.; Mao, S.; Rattenbury, N. (Eds.) et al Proceedings of the Manchester Microlensing Conference: The 12th International Conference and ANGLES Microlensing Workshop. Proceedings of Science, PoS (GMC8)020 (2008)

We present the main results of the first long-term spectrophotometric monitoring of the ``Einstein cross'' Q2237+0305 and of the single-epoch spectra of the lensed quasar J1131-1231. From October 2004 to ... [more ▼]

We present the main results of the first long-term spectrophotometric monitoring of the ``Einstein cross'' Q2237+0305 and of the single-epoch spectra of the lensed quasar J1131-1231. From October 2004 to December 2006, we find that two prominent microlensing events affect images A & B in Q2237+0305 while images C & D remain grossly unaffected by microlensing on a time scale of a few months. Microlensing in A & B goes with chromatic variations of the quasar continuum. We observe stronger micro-amplification in the blue than in the red part of the spectrum, as expected for continuum emission arising from a standard accretion disk. Microlensing induced variations of the CIII] emission are observed both in the integrated line intensity and profile. Finally, we also find that images C & D are about 0.1-0.3 mag redder than images A & B. The spectra of images A-B-C in J1131-1231 reveal that, in April 2003, microlensing was at work in images A and C. We find that microlensing de-amplifies the continuum emission and the Broad Line Region (BLR) in these images. Contrary to the case of Q2237+0305, we do not find evidence for chromatic microlensing of the continuum emission. On the other hand, we observe that the Balmer and MgII broad line profiles are deformed by microlensing. These deformations imply an anti-correlation between the width of the emission line and the size of the corresponding emitting region. Finally, the differential microlensing of the FeII emission suggests that the bulk of FeII is emitted in the outer parts of the BLR while another fraction of FeII is produced in a compact region. [less ▲]

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See detailA Statement on Ethics From the HEART Group.
LANCELLOTTI, Patrizio ULg

in Circulation Research (2008), 102(9), 104-5

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