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See detailKATP channel openers: tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1 -dioxides
Lebrun, P.; Becker, B.; Morel, N. et al

in Biochemical Pharmacology (2008), 75

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See detailTemps de travail et horaires atypiques : Impact sur le conflit travail-famille et le bien-être.
Hansez, Isabelle ULg; Etienne, Anne-Marie ULg; Breuer, Lara

in Balikdjiian, A.; Salengros, P.; Lemoine, C. (Eds.) et al Analyse du travail, technologie et psychologie de la consommation. Actes du 14ème congrès de Psychologie du Travail et des Organisations de Langue Française. (2008)

L’étude présentée propose d’examiner, parmi 184 travailleurs luxembourgeois, le lien entre le temps de travail, y compris les horaires atypiques, l’interaction vie privée-vie professionnelle et le bien ... [more ▼]

L’étude présentée propose d’examiner, parmi 184 travailleurs luxembourgeois, le lien entre le temps de travail, y compris les horaires atypiques, l’interaction vie privée-vie professionnelle et le bien-être au travail. Les résultats principaux relèvent un effet significatif (négatif) du travail de week-end, du travail de nuit et des horaires compressés sur l’influence négative travail-famille. Un effet significatif (négatif) de l’horaire compressé sur l’influence positive travail-famille est aussi mis en évidence. Enfin, le temps partiel serait lié à un niveau de stress plus faible et une influence négative du travail sur la famille plus faible. Cette dernière jouerait par ailleurs un rôle de modérateur partiel entre le temps de travail et le stress négatif. [less ▲]

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See detailSynthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators
Khelili, S.; Florence, Xavier ULg; Bouhadja, M. et al

in Bioorganic & Medicinal Chemistry (2008), 16

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See detailPCDD, PCDF AND PCB DETERMINATION IN DOLPHINS REVEALS A WORLD HOTSPOT FOR PCBS IN GUANABARA BAY, BRAZIL
Dorneles, Paulo; Lailson-Brito, José; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2008), 70

The main objective of the present study was to determine the current concentrations of PCDDs, PCDFs and PCBs in dolphins from a region of high industrialization and urbanization in the Southern Hemisphere ... [more ▼]

The main objective of the present study was to determine the current concentrations of PCDDs, PCDFs and PCBs in dolphins from a region of high industrialization and urbanization in the Southern Hemisphere. Since most of these compounds biomagnify in food chains and changes in ratios of stable isotopes of nitrogen (15N/14N) have been used to elucidate trophic relationships 7, measurements of these isotopes have been carried out in marine tucuxi dolphins and their prey in Guanabara Bay. Stable isotopes were measured, firstly, to quantitatively assess the trophic level of the dolphin, and, secondly, to provide information for future human risk assessment investigations related to fish consumption [less ▲]

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See detailEtude de l'écologie des communautés macrophytiques en vue de fournir des indicateurs paléo-environnementaux pour les lacs-cratères d'Afrique de l'Est
Lebrun, Julie ULg; Mahy, Grégory ULg

in Anne Bonis (Ed.) Actualité de la recherche en écologie des communautés végétales. Actes du quatrième Colloque ECOVEG: Rennes, 12-14 mars 2008 (2008)

This research is part of an integrated paleoecological project which aims at coupling reconstructions of past vegetation and water-quality changes with climate variability. Crater-lakes from East Africa ... [more ▼]

This research is part of an integrated paleoecological project which aims at coupling reconstructions of past vegetation and water-quality changes with climate variability. Crater-lakes from East Africa are favourable to the conservation of proxy indicators such as plant macrofossils used to reconstruct the lake ecosystem. The study of modern macrophytic communities in relationship with present environmental parameters was the first step of this research. Eventually, it will allow us to select species with high proxy-indicator value. Phytosociologic and environmental data were collected in 18 crater-lakes in South-western Uganda. In each relevé, species abundance and habitat conditions were described. Environmental parameters were used to develop a lake typology. A cluster analysis identified 6 aquatic and semi-aquatic communities and the indicator species were highlighted. The CA ordination emphasized the importance of geography, physico-chemistry and trophic level in the community structure. Temperature, pH, sediment type, depth and slope were the most correlated parameters to floristic variation in the CCA ordination. These preliminary results give some trends about the ecology of macrophytes communities. A complete dataset and the study of species ecological range will allow us to go further in the ecological significations of macrofossils. [less ▲]

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See detailSynthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators.
Francotte, Pierre ULg; De Tullio, Pascal ULg; Podona, Tchao et al

in Bioorganic & Medicinal Chemistry (2008), 16(23), 9948-56

Taking into account structure-activity relationships obtained with our previous series, new diversely substituted 1,2,4-pyridothiadiazine 1,1-dioxides were designed to obtain novel AMPA potentiators. The ... [more ▼]

Taking into account structure-activity relationships obtained with our previous series, new diversely substituted 1,2,4-pyridothiadiazine 1,1-dioxides were designed to obtain novel AMPA potentiators. The aim of this work was focused on the improvement of lipophilicity, which is well known as a critical parameter to obtain in vivo active central nervous system agents. For this purpose, two positions on the pyridine ring were privileged to insert selected groups. Among the synthesized compounds emerged 7-chloro-4-ethyl-3,4-dihydro-2H-pyrido[2,3-e]-[1,2,4]-thiadiazine 1,1-dioxide (12d), which was evaluated in two memory tests in Wistar rats and showed cognition enhancing effects after intraperitoneal injection at doses as low as 0.3mg/kg. [less ▲]

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See detailA One-Phase Thermomechanical Constitutive Model for the Numerical Simulation of Semi-Solid Thixoforming
Koeune, Roxane ULg; Ponthot, Jean-Philippe ULg

in Proceedings of ESAFORM 2008, Conference on material forming (2008)

A thermo mechanical one-phase elasto-visco-plastic constitutive law has been developed in order to model thixoforming processes. The simulation of a simple academic 2D test has revealed the forces and ... [more ▼]

A thermo mechanical one-phase elasto-visco-plastic constitutive law has been developed in order to model thixoforming processes. The simulation of a simple academic 2D test has revealed the forces and weaknesses of the proposed model. [less ▲]

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See detailDifferences and similarities in the sensory and cognitive signatures of voice-hearing, intrusions and thoughts
Moritz, S.; Laroi, Frank ULg

in Schizophrenia Research (2008), 102(1-3), 96-107

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See detailImmune-mediated respiratory and cardiac disease
Clercx, Cécile ULg

in Clinical Immunology of the Dog and Cat”, 2d edition (2008)

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See detailA comparison of triangle and quadrangle finite elements for large strain elastoplastic formulations
KARASEVA, Olga; Stainier, Laurent ULg; Careglio, C. et al

in Proceedings of ACOMEN’2008, Advanced Computational Methods in Engineering (2008)

The paper presents a comparative study of different elastoplastic large strain formulations used in research groups in Mendoza and Li`ege. The comparison is focused on a few academic standardized problems ... [more ▼]

The paper presents a comparative study of different elastoplastic large strain formulations used in research groups in Mendoza and Li`ege. The comparison is focused on a few academic standardized problems, in particular necking of a cylindrical bar in tension. Stress distribution at necking section, as well as load histories are analyzed for all three formulations. Two other test cases consider bending of the so-called ”Greco” beam and upsetting of a cylinder. Numerical results show that all approaches yield very similar results and thus are equally valid. Furthermore, quadratic 6-noded triangles provide a good alternative to bilinear quadrangles, even if sometimes they appear to be more sensitive to big distorsions. [less ▲]

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See detailMECHANICAL PRETREATMENT EFFECT ON CELLULOSE ENZYMATICAL HYDROLYSIS
Jacquet, Nicolas ULg; Paquot, Michel ULg

Poster (2008)

Lignocellulosic materials are very interesting for the production of bioethanol after chemical or enzymatical hydrolysis of cellulose. To optimise production rate and increase the output of these ... [more ▼]

Lignocellulosic materials are very interesting for the production of bioethanol after chemical or enzymatical hydrolysis of cellulose. To optimise production rate and increase the output of these processes, different kinds of pre-treatments (grinding, steam explosion…) are often needed for opening the fibrous structure of the cellulose and increase the specific surface of the materials. The present study is focused on two models of “pure” cellulose (cellulose C200 microtechnik, cellulose FD100 FMC biopolymer) in order to analyse the effects of mechanical pretreatments on the kinetics and yields of hydrolysis. The cristallinity index differentiates the two celluloses. Hydrolysis is realized by a cellulase mix (cellulase Trichoderma reesei C2730, Novozyme; cellobiase Aspergillus niger C6105). Results present the influence of homogenisation pretreatment and analyse differents parameters of this technology. [less ▲]

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See detailCorynebacterium-associated skin infections.
Blaise, Géraldine; Nikkels, Arjen ULg; Hermanns-Lê, Trinh ULg et al

in International Journal of Dermatology (2008), 47(9), 884-90

BACKGROUND: Corynebacterium spp. are diphtheroid bacteria responsible for pitted keratolysis, a common plantar infection confined to the thick stratum corneum. AIM: To study a series of demographic ... [more ▼]

BACKGROUND: Corynebacterium spp. are diphtheroid bacteria responsible for pitted keratolysis, a common plantar infection confined to the thick stratum corneum. AIM: To study a series of demographic features of patients suffering from pitted keratolysis, and to present a review of the Corynebacterium-associated infections, including pitted keratolysis, erythrasma, and trichobacteriosis. MATERIALS AND METHODS: A 2-year, two-center, prospective survey assessed the demographics of pitted keratolysis, including age, gender, site of infection, symptoms, patients' complaints, the use of protective and/or occlusive shoes, seasonality of diagnosis, drug intake, associated skin signs (including dyshidrosis, erythrasma, and trichobacteriosis), recurrences, and previous diagnoses and treatments. RESULTS: The mean age of the 53 patients with pitted keratolysis was 24.9 years (range, 10-57 years). The male to female ratio was 7.8:1. The soles of both feet were commonly involved (92.4%). Pressure-bearing areas were the usual sites of infection, ranging from restricted involvement of the toes (12/53, 22.6%) to spreading to the entire plantar surface (15/53, 28.3%). A total of 36 (68%) of the 53 patients complained of hyperhidrosis. An unpleasant smell and pain were noted by 35 (66%) and 25 (47%) of the 53 patients, respectively. Occlusive and protective shoes were worn in 51 (96.2%) and 31 (58.4%) of the 53 cases, respectively. CONCLUSION: Pitted keratolysis commonly affects young male patients wearing protective shoes for professional reasons, inducing a moist and warm environment. Hyperhidrosis, an unpleasant smell, and pain are the main clinical complaints. [less ▲]

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See detailL'exercice du pouvoir depuis la réforme de l'Etat (1970-2007)
Pâques, Michel ULg

in Demoulin, B. (Ed.) Le palais des princes-évêques de Liège (2008)

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See detailShock-like sensations associated with duloxetine discontinuation.
Pitchot, William ULg; Ansseau, Marc ULg

in Annals of Clinical psychiatry : Official Journal of the American Academy of Clinical Psychiatrists (2008), 20(3), 175

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See detailWalking Waters, édition bilingue (recueil de poèmes de Michael Curtis)
Pagnoulle, Christine ULg

Book published by Les Vanneaux (2008)

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See detail1.2 Evolution du cadre législatif et prise en charge des mineurs - Introduction
Gavray, Claire ULg

in Bailleau, Francis (Ed.) Evolution ou rupture ? La justice des mineurs en question (2008)

acts devoted to the evolutions in the European systems of justice of the minors.

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See detailLa biosynthèse des isoprenoides chez les pucerons: une cible potentielle de nouveaux bio-insecticides?
Vandermoten, Sophie ULg; Cusson, Michel; Francis, Frédéric ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2008), 12(4),

Actuellement, le contrôle des pucerons repose en grande partie sur l'utilisation d'insecticides de synthèse. Toutefois, l'effet néfaste de ceux-ci sur l'environnement, ainsi que le développement croissant ... [more ▼]

Actuellement, le contrôle des pucerons repose en grande partie sur l'utilisation d'insecticides de synthèse. Toutefois, l'effet néfaste de ceux-ci sur l'environnement, ainsi que le développement croissant de populations résistantes conduit à rechercher de nouvelles méthodes de lutte. Parmi celles-ci, une des voies actuellement envisagée est la formulation de nouveaux bio-insecticides ciblant et perturbant les fonctions biochimiques de l'insecte. En raison de la haute spécificité des agents utilisés, ces méthodes de contrôle des ravageurs ne présentent généralement que peu de risque pour l'environnement, les espèces non ciblées et la santé humaine. Dans le contexte de la lutte contre les pucerons, la voie de biosynthèse des isoprénoïdes, et plus particulièrement les enzymes de la famille des " short-chain " isoprényle diphosphate synthases, s'avère être une cible intéressante pour le développement de ces nouveaux agents de contrôle. En effet, chez les pucerons, cette voie de biosynthèse est associée à la production des mono- et sesquiterpènes, deux classes d'isoprénoïdes jouant des rôles importants au niveau de la physiologie des pucerons [less ▲]

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