References of "2008"
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See detailDetection of glucocorticoid bioactivity in bovine urine samples using a reporter gene assay
Connolly, Lisa; Kai, C.; Van Der Heiden, Edwige ULg et al

in Proceedings of the Euroresidue VI Conference (2008)

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See detailPronominale hersemantisering in het Nederlandse genussysteem
De Vos, Lien ULg

Master's dissertation (2008)

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See detailTotal Electron Content monitoring using triple frequency GNSS data: a three-step approach
Spits, Sandrine; Warnant, René ULg

Conference (2008)

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See detailIn Unordnung erstarrt
Schlagheck, Peter ULg; Richter, K.

Article for general public (2008)

Experimente mit kalten Atomen zeigen erstmals direkt die Anderson-Lokalisierung von Materiewellen.

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See detaillocalized modulation of testosterone action: Function of steroid receptor coactivators in the brain
Charlier, Thierry ULg; Balthazart, Jacques ULg

in Ardis, L. I. (Ed.) New research on testosterone (2008)

Testosterone, through its activation of androgen and estrogen receptors, has been shown to play a critical role in brain development and physiology. Recent studies have shown that the activity of these ... [more ▼]

Testosterone, through its activation of androgen and estrogen receptors, has been shown to play a critical role in brain development and physiology. Recent studies have shown that the activity of these receptors can be modulated by the interaction with several proteins and, in particular, that coactivators are required to enhance their transcriptional activity. The steroid receptor coactivator-1, SRC-1 is the best-characterized coactivator and we review here the current knowledge on the distribution, regulation of expression and function of this protein in the brain, focusing mostly on our work in Japanese quail. As expected for a ubiquitous coactivator, SRC-1 is present throughout the brain in both mammalian and avian species but is found in particularly high concentrations in testosterone-sensitive areas such as the preoptic area in rat and Japanese quail and in the song control nuclei in songbirds. Further analysis demonstrates that the expression of SRC-1 is not constitutive but regulated in specific brain areas by the sex, acute stress and testosterone treatment. In addition, the protein concentration appears to fluctuate through the day in some brain regions. These modulations of SRC-1 expression by endogenous (sex) and exogenous (stress) factors could potentially exacerbate at specific times the competition or squelching between different nuclear receptors and therefore decrease the biological response induced by one or another hormonal system. Although the existence of such a phenomenon has not yet been demonstrated in a functionally intact biological system, the effects of SRC-1 antisense treatments clearly strengthen this hypothesis. Indeed, the decrease of SRC-1 expression in the hypothalamus induced by antisense oligonucleotide injections clearly inhibited both estrogen-dependent male sexual behavior and androgen-dependent pre- and post-copulatory displays (strut) in Japanese quail, therefore demonstrating a role of the coactivator in the transcriptional activation induced by both estrogen and androgen receptors. Interestingly, the inhibitory effect on sexual behavior of SRC-1 knock down was not systematically associated with modifications of several histological (definition of median preoptic nucleus [POM] using Nissl staining), immunohistochemical (aromatase and vasotocin cells and fibers in the POM) and biochemical (aromatase enzymatic activity) markers of testosterone action in the brain. This dissociation of the effects of SRC-1 on behavior on the one hand and on aromatase and POM neurochemistry on another hand suggests that other system(s) involved in the activation of male sexual behavior are likely more sensitive to a decrease of SRC-1 expression. In future research, it will be essential to determine the other cofactors involved in specific physiological responses and to define whether these coactivators act synergistically, in parallel or independently in the modulation of the activity of one or several nuclear receptors linked to a particular physiological event. In several biological models, the observed changes in concentration of the circulating hormone and /or its receptors are apparently not sufficient to explain the physiological and behavioral responses observed after testosterone treatment. The discovery of steroid receptor coactivators opens new perspectives in the study of the molecular basis of steroid action at the level of the organism and a complete understanding of the mechanisms of steroid action will not be achieved without a detailed characterization of nuclear receptor cofactors. [less ▲]

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See detailIm Zeichen des Ödipuskomplexes. Mutterbindung und Vaterhass in Günter Grass’ Autobiographie „Beim Häuten der Zwiebel“ und seinem Roman „Die Blechtrommel“.
Pontzen, Alexandra ULg

in Hagestedt, Lutz (Ed.) Literatur als Lust. Begegnungen zwischen Poesie und Wissenschaft: Festschrift für Thomas Anz zum 60. Geburtstag (2008)

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See detailOn the transferability of concepts and its significance for landscape ecology.
Bogaert, Jan ULg; Barima, Y S S

in JME : Journal of Mediterranean Ecology (2008), 9

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See detailTunisian Table Olive Phenolic Compounds And Their Antioxidant Capacity
Ben Othman, N.; Weber, Dominique ULg; Thonart, Philippe ULg et al

in Journal of Food Science (2008), 73(4),

For the 1st time, 4 olive cultivars, theMeski, Chemlali, Besbessi, and Tounsi, fromthe Tunisian market were investigated to evaluate the phenolic compounds’ contribution in nutritional value of table ... [more ▼]

For the 1st time, 4 olive cultivars, theMeski, Chemlali, Besbessi, and Tounsi, fromthe Tunisian market were investigated to evaluate the phenolic compounds’ contribution in nutritional value of table olives. From the Meski cultivar, we have chosen 4 different samples to evaluate differences within the same cultivar. Basic characteristics and total phenolic content were evaluated in flesh and kernel. The highest value of flesh phenolic content was observed in sample M4 of the Meski cultivar; however, the lowest value was observed in the Besbessi cultivar and they were 1801 and 339 mg GA/100 g dry weight, respectively. Themain simple phenolic compounds identified in flesh extracts are hydroxytyrosol, tyrosol, and vanillic acid. Oleuropein was not detected in any samples. The antioxidant activity of Tunisian olive flesh varies between 212 and 462 μM TEAC/g of dry weight. Antioxidant activity of olives was related to their phenolic content but we found a low correlation between phenolic content and TEAC [less ▲]

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See detailPeinlichkeit und Imagination
Pontzen, Alexandra ULg

in Ziemer, Gesa; Zumsteg, Simon; Huber, Jörg (Eds.) Archipele des Imaginären (2008)

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See detailLigands playing musical chairs with G-quadruplex DNA: A rapid and simple displacement assay for identifying selective G-quadruplex binders
Monchaud, David; Allain, C.; Bertrand, Hélène et al

in Biochimie (2008), 90(8), 1207-1223

We report here the details of G4-FID (G-quadruplex fluorescent intercalator displacement), a simple method aiming at evaluating quadruplex DNA binding affinity and quadruplex- over duplex-DNA selectivity ... [more ▼]

We report here the details of G4-FID (G-quadruplex fluorescent intercalator displacement), a simple method aiming at evaluating quadruplex DNA binding affinity and quadruplex- over duplex-DNA selectivity of putative ligands. This assay is based on the loss of fluorescence upon displacement of thiazole orange from quadruplex and duplex-DNA matrices. The original protocol was tested using various quadruplex and duplex-DNA targets, and with a wide panel of G-quadruplex ligands belonging to different families (i.e. from quinacridines to metalloorganic ligands) likely to display various binding modes. The reliability of the assay is further supported by comparisons with FRET-melting and ESI-MS assays. [less ▲]

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See detailPietätlose Rezeption? – Elfriede Jelineks Umgang mit der Tradition in „Die Kinder der Toten“.
Pontzen, Alexandra ULg

in Müller, Sabine; Theodorsen, Cathrin (Eds.) Elfriede Jelinek – Tradition, Politik und Zitat. (2008)

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See detailUne histoire à plusieurs voix entre le pays soninké (Mali) et la France
Razy, Elodie ULg

in Krauskopff, G. (Ed.) Les faiseurs d’histoires (2008)

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See detailCalculul Constructiilor Metalice la Actiunea Focului
Franssen, Jean-Marc ULg; Zaharia, Raul

Book published by Editura Orizonturi Universitare (2008)

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See detailCoherent backscattering of Bose-Einstein condensates in two-dimensional disorder potentials
Hartung, Michael; Wellens, Thomas; Mueller, Cord A et al

in Physical Review Letters (2008), 101(2), 020603

We study quantum transport of an interacting Bose-Einstein condensate in a two-dimensional disorder potential. In the limit of a vanishing atom-atom interaction, a sharp cone in the angle-resolved density ... [more ▼]

We study quantum transport of an interacting Bose-Einstein condensate in a two-dimensional disorder potential. In the limit of a vanishing atom-atom interaction, a sharp cone in the angle-resolved density of the scattered matter wave is observed, arising from constructive interference between amplitudes propagating along reversed scattering paths. Weak interaction transforms this coherent backscattering peak into a pronounced dip, indicating destructive instead of constructive interference. We reproduce this result, obtained from the numerical integration of the Gross-Pitaevskii equation, by a diagrammatic theory of weak localization in the presence of nonlinearity. [less ▲]

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See detailThermo-plasticity of soils at various saturation states: a constitutive model
François, Bertrand ULg; Laloui, Lyesse

in 3rd International Workshop of Young Doctors in Geomechanics (2008)

This paper presents a highly-coupled thermo-plasticity model for unsaturated soils. The effect of temperature on the mechanics of unsaturated soils is briefly addressed. Then the equations of the ... [more ▼]

This paper presents a highly-coupled thermo-plasticity model for unsaturated soils. The effect of temperature on the mechanics of unsaturated soils is briefly addressed. Then the equations of the developed model, so-called ACMEG-TS, are detailed. Finally, the model is validated by the means of comparisons with experiments. This constitutive model constitutes an effective tool for modelling the thermo-hydro-mechanical (THM) behaviour of geomaterials involved in the confinement of nuclear waste disposal. [less ▲]

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See detailSynthesis of novel functional aliphatic polyesters
Schmeits, Stephanie ULg; Riva, Raphaël ULg; Jérôme, Christine ULg et al

in Polymer Preprints (2008), 49(1), 222-223

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See detailL'apparition du quotidien dans l'art
Steinmetz, Rudy ULg

Conference given outside the academic context (2008)

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See detailExpert Evidence before the EC Courts
Barbier de La Serre, Eric; Sibony, Anne-Lise ULg

in Common Market Law Review (2008), 45(4), 941985

The EC courts are regularly asked to rule on complex scientific and technical matters, as illustrated by cases concerning the foot and mouth crisis or conglomerate effects in merger control. In order to ... [more ▼]

The EC courts are regularly asked to rule on complex scientific and technical matters, as illustrated by cases concerning the foot and mouth crisis or conglomerate effects in merger control. In order to apprehend these technical issues, the EC courts may, like any other court, rely on experts who are appointed either by the courts themselves or by the parties. However, the law on the use of expert evidence by the EC courts is unclear on many aspects. The purpose of this article is therefore to set out briefly the law on expert evidence, to explore how the EC courts use it and to assess whether improvements are desirable. Section 2 of this article describes how the EC courts use “neutral” expert evidence (i.e., evidence obtained through an expert’s report commissioned by the court). An analysis of the case law reveals a paradox: while the status of neutral expert evidence is clearly defined by the rules of procedure governing the EC courts, such evidence is rarely used in practice. Section 2 therefore also endeavours to explain why the use of neutral expert evidence remains exceptional. Section 3 focuses on how the EC courts use “partisan” expert evidence (i.e., expert evidence that is voluntarily submitted by the parties). It shows that partisan expert evidence is the mirror image of neutral expert evidence: while its procedural status is unclear, it is widely used before the EC courts. Finally, in Section 4, it is argued that this situation is not wholly satisfactory. It is submitted inter alia that there is no convincing justification for systematic self-restraint over technical issues. Some changes are therefore explored which could be contemplated in order to improve the use of expert evidence by the EC courts. [less ▲]

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