References of "2007"
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See detail“‘Whit an eedjit!’ / ‘Quén bièsse!’, can Walloon echo Scots?”
Pagnoulle, Christine ULiege

Scientific conference (2007, December 08)

After an amused comment on the different perceptions of varieties in the use of English as expressed on the cover of translated books, the paper focuses on what is involved in the translation of Scots ... [more ▼]

After an amused comment on the different perceptions of varieties in the use of English as expressed on the cover of translated books, the paper focuses on what is involved in the translation of Scots English, contrasting the situation when the text is entirely in Scots (in this case poems I translated for a bilingual anthology) and the self-conscious contrast of Scots and Standard English in Liz Lochhead's play Mary Queen of Scots Got Her Head Chopped Off. As it is a play, so meant to be performed, and as the relation of Scots to English is historically very similar to that of Walloon to French, I argue for the local introduction of Walloon forms, but since Walloon is hardly understood any more (contrary to Scots), the text has to make sure that French doubles up what is said in Walloon. [less ▲]

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See detailL'enfermement des enfants
Mormont, Christian ULiege

Conference given outside the academic context (2007)

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See detailHistone deacetylase 7 silencing alters endothelial cell migration, a key step in angiogenesis
Mottet, Denis ULiege; Bellahcene, Akeila ULiege; Pirotte, Sophie ULiege et al

in Circulation Research (2007), 101(12), 1237-1246

Global inhibition of class I and II histone deacetylases (HDACs) impairs angiogenesis. Herein, we have undertaken the identification of the specific HDAC(s) with activity that is necessary for the ... [more ▼]

Global inhibition of class I and II histone deacetylases (HDACs) impairs angiogenesis. Herein, we have undertaken the identification of the specific HDAC(s) with activity that is necessary for the development of blood vessels. Using small interfering RNAs, we observed that HDAC7 silencing in endothelial cells altered their morphology, their migration, and their capacity to form capillary tube-like structures in vitro but did not affect cell adhesion, proliferation, or apoptosis. Among several factors known to be involved in angiogenesis, platelet-derived growth factor-B (PDGF-B) and its receptor (PDGFR-beta) were the most upregulated genes following HDAC7 silencing. We demonstrated that their increased expression induced by HDAC7 silencing was partially responsible for the inhibition of endothelial cell migration. In addition, we have also shown that treatment of endothelial cells with phorbol 12-myristate 13-acetate resulted in the exportation of HDAC7 out of the nucleus through a protein kinase C/protein kinase D activation pathway and induced, similarly to HDAC7 silencing, an increase in PDGF-B expression, as well as a partial inhibition of endothelial cell migration. Collectively, these data identified HDAC7 as a key modulator of endothelial cell migration and hence angiogenesis, at least in part, by regulating PDGF-B/PDGFR-beta gene expression. Because angiogenesis is required for tumor progression, HDAC7 may represent a rational target for therapeutic intervention against cancer. [less ▲]

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See detailLes apories du matérialisme dialectique
Seba, Jean-Renaud ULiege

Conference (2007, December 07)

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See detailSandostatin LAR acromegaly global advisory board meeting
Beckers, Albert ULiege

Scientific conference (2007, December 07)

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See detailConciliation qualité de vie au travail et qualité de vie en général
Etienne, Anne-Marie ULiege

Conference (2007, December 07)

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See detailSalt, hypertension and the kidneys
Krzesinski, Jean-Marie ULiege

Conference (2007, December 07)

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See detailRisque cardiovasculaires chez les jeunes étudiants
Krzesinski, Jean-Marie ULiege

Conference (2007, December 07)

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See detailA SYSTEMS BIOLOGY APPROACH TARGETING NEUROLOGICAL DISEASE- FROM GENOMICS TO IN SILICO PREDICTIVE MODELS
Vafiadaki, Elizabeth; Depaulis, Antoine; Jackers, Pascale ULiege et al

Poster (2007, December 07)

VALAPODYN, a European Commission funded research network, is constructing an original system biology approach for the development of multidisciplinary functional genomics related to complex biological ... [more ▼]

VALAPODYN, a European Commission funded research network, is constructing an original system biology approach for the development of multidisciplinary functional genomics related to complex biological processes and cellular networks. The aim is to generate an innovative model on the dynamics of molecular interaction networks (MIN) in relation to cell death and survival for the detection of new therapeutic targets to treat human brain diseases. Proteomic databases are being used along with leading microarray and proteomics platform systems to investigate protein-protein interactions and regulation networks. This will help to identify and validate biological targets in complex intracellular pathways to cure multifactorial diseases. Dynamic modeling specifically addresses the systems biology of complex cellular pathways and transcriptional networks. Novel dynamic models will be validated by testing the selected drug targets on innovative in vivo and in vitro models of CNS pathologies. The first phase involves fundamental genomics research, integrating statistical data analysis with real biological data in order to functionally annotate genes and proteins. Using Affymetrix microarrays, we are evaluating whole genome expression profiles generated from dissected mouse brains following different treatments at various time points. Through the simultaneous analysis of ~40,000 genes, critical pathways and molecular targets implicated in neurodegeneration are being revealed. VALAPODYN develops a dynamic and quantitative analysis method for new therapeutic targets through MIN dynamic models. It will provide a cutting-edge highly accurate in silico tool for identifying novel and effective therapeutic targets in a faster, more efficient and more economical way than it is possible today. (www.valapodyn.eu). dsanoudou@bioacademy.gr [less ▲]

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See detailLiaison autoroutière « CHB » : la Wallonie s’empêtre dans des choix dépassés
Lamarche, Caroline; Leprince, Pierre ULiege; Outers, Jean-Luc et al

Article for general public (2007)

Magnétique, l'affiche mobilisatrice pour la marche « Ensemble pour le climat et la solidarité » de ce 8 décembre à Bruxelles, ces humains nus convergeant vers notre planète à protéger. Superbe symbole qui ... [more ▼]

Magnétique, l'affiche mobilisatrice pour la marche « Ensemble pour le climat et la solidarité » de ce 8 décembre à Bruxelles, ces humains nus convergeant vers notre planète à protéger. Superbe symbole qui ne doit pas nous faire oublier l'avertissement placé en tête d'affiche : « Ça commence ici ». « Ici », on nous le répète, c'est ma maison où je peux fermer le robinet, visser des ampoules économiques, baisser le chauffage, placer du double vitrage. Mais il y a un autre « ici » : notre beau coin d'Europe, nos villes et nos campagnes. Et là, pour Noël, le gouvernement wallon s'apprête à déposer un énorme cadeau dans nos petits souliers. Un truc neuf ? Non, vieux de presque un demi-siècle. Pas trop crade ? De luxe au contraire : 400 millions d'euros. Au moment de la conférence de Bali sur le changement climatique, ça a à voir avec le climat ? Mais oui ! Et c'est… ? Un permis de construire. Des canaux, des voies ferrées, des trams ? Non. Une nouvelle autoroute. [...] [less ▲]

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See detailDarwin: required performance (invited)
Absil, Olivier ULiege

Scientific conference (2007, December 06)

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See detailL’Imaginaire des Pays-Bas dans la littérature française du XIXe siècle
Andringa, Kim ULiege

Doctoral thesis (2007)

The imagination of the Netherlands comes close to a mythoid aggregate. The corpus transmits a superficial and picturesque imagery, based on tourist, pictorial and historical sources. The tourist ... [more ▼]

The imagination of the Netherlands comes close to a mythoid aggregate. The corpus transmits a superficial and picturesque imagery, based on tourist, pictorial and historical sources. The tourist conventions reinforce its stereotypical and anachronistic nature. The anachronism is also typical of the images borrowed from paintings of the Dutch school and a few art historians. Realism is most appreciated when poetically tinged, as with Rembrandt who reveals the boundary between dream and reality. History provides the authors with heroic or dramatic episodes, as well as with legends expressing national character or the struggle against the waters. At the dawn of the 20th century, the imagination of the Netherlands becomes more introspective. Societal changes and especially the industrialisation put the place of man in question. We have subjected three groups of images to a symbolical analysis. First, the group of miniaturised dwelling places, that express a unfulfilled desire for intimacy and a refuge out of time. Then, a group related to the painting as a mirror. These boundary images of an inaccessible space express the same disappointed desire. The sea images express progressive ideas as well as fear of mechanization at the same time. The illusion of the fantastic and the phantasmagoria make it possible to vanquish the setbacks suffered through the figures of intimacy. Against the industrialisation, against the changes of modern society, as well as against mass tourism, the author will oppose his imaginary experience of the world, and through his description will give a autoreferential image, revealing of his dreams and desires. L’imaginaire des Pays-Bas se rapproche d’un agrégat mythoïde. Le corpus véhicule une imagerie superficielle et pittoresque, construite autour de sources touristiques, picturales et historiques. Les conventions du tourisme en renforcent le caractère stéréotypée et anachronique. L’anachronisme caractérise aussi les images empruntées aux tableaux de l’école hollandaise et à quelques historiens de l’art. Le réalisme est surtout apprécié lorsqu’il est mêlé de poésie, comme chez Rembrandt qui révèle la frontière entre réel et rêve. L’Histoire fournit aux auteurs des épisodes héroïques ou dramatiques, et des légendes traduisant le caractère national ou la lutte contre les eaux. À l’aube du 20e siècle, l’imaginaire des Pays-Bas devient plus introspectif. Les changements sociétaux et surtout l’industrialisation remettent en cause la place de l’homme. Nous avons soumis trois groupes d’images à une analyse symbolique. D’abord celui des habitations miniaturisées, exprimant un désir d’intimité et de refuge hors du temps non satisfait. Le second se rattache à la peinture qui devient miroir. Ces images frontalières d’un espace inaccessible expriment le même désir déçu. Les images marines véhiculent à la fois des idées progressistes et la peur du machinisme. L’illusion du fantastique et de la fantasmagorie permet de surmonter les échecs rencontrés par les figures de l’intimité. À l’industrialisation, aux changements de la société moderne, au tourisme de masse aussi, l’auteur va opposer son expérience imaginaire du monde et à travers sa description, il va donner une image suiréférentielle révélatrice de ses rêves et désirs. [less ▲]

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See detailHistone Deacetylases: Target Enzymes for Cancer Therapy
Mottet, Denis ULiege; Castronovo, Vincenzo ULiege

in Clinical & Experimental Metastasis (2007)

Epigenic regulation of gene transcription has recently been the subject of a fast growing interest particularly in the field of cancer. Enzymatic acetylation and deacetylation of the epsilon-amino groups ... [more ▼]

Epigenic regulation of gene transcription has recently been the subject of a fast growing interest particularly in the field of cancer. Enzymatic acetylation and deacetylation of the epsilon-amino groups of lysine residues from nucleosomal histones, represents major molecular epigenic mechanisms controlling gene expression. Histone deacetylases (HDACs) and histone acetyl transferases (HAT) represent the two families of enzymes in charge of the control of the level of acetylation of the histone tails. By removing the acetyl groups that abrogate the positive charge of the lysine residues that maintain the histone tails attached to DNA, HDACs repress transcription. In mammals, these latter enzymes form three groups of related enzymes based on their sequence homology and are classified as HDACs I, II and III. Global inhibition of the HDACs I and II groups results in cell growth arrest and apoptosis of cancer cells and alters tumor growth in in vivo experimental models. Their surprisingly low general toxicity and their impressive efficiency in preclinical cancer models has led to consider HDAC inhibitors as very promising new anticancer pharmacological agents. In this review, we attempt to give a comprehensive overview of the role and the involvement of HDAC in carcinogenesis as well as the current progress on the development of HDAC general and specific inhibitors as new cancer therapies. [less ▲]

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See detailLa question des langues dans l’Empire Romain : l’enseignement du latin et du grec dans l’Antiquité.
Rochette, Bruno ULiege

Scientific conference (2007, December 05)

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See detailFrom the numerisation of the Soil Map of Wallonia to a real information and management tool
Legrain, Xavier ULiege; Bah, Boubacar Billo ULiege; Veron, Philippe et al

Poster (2007, December 05)

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See detailRegulation of CXCL8/IL-8 by Zonula Occludens-1 during breast tumor-associated epithelial-to-mesenchymal transitions.
Mestdagt, M; Polette, M; Bindels, S et al

Poster (2007, December 05)

Detailed reference viewed: 11 (0 ULiège)