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See detailWithaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity
Kaileh, Mary; Vanden Berghe, Wim; Heyerick, Arne et al

in Journal of Biological Chemistry (2007), 282(7), 4253

The transcription factor NFkappaB plays a critical role in normal and pathophysiological immune responses. Therefore, NFkappaB and the signaling pathways that regulate its activation have become a major ... [more ▼]

The transcription factor NFkappaB plays a critical role in normal and pathophysiological immune responses. Therefore, NFkappaB and the signaling pathways that regulate its activation have become a major focus of drug development programs. Withania somnifera (WS) is a medicinal plant that is widely used in Palestine for the treatment of various inflammatory disorders. In this study we show that the leave extract of WS, as well as its major constituent withaferin A (WA), potently inhibits NFkappaB activation by preventing the tumor necrosis factor-induced activation of IkappaB kinase beta via a thioalkylation-sensitive redox mechanism, whereas other WS-derived steroidal lactones, such as withanolide A and 12-deoxywithastramonolide, are far less effective. To our knowledge, this is the first communication of IkappaB kinase beta inhibition by a plant-derived inhibitor, coinciding with MEK1/ERK-dependent Ser-181 hyperphosphorylation. This prevents IkappaB phosphorylation and degradation, which subsequently blocks NFkappaB translocation, NFkappaB/DNA binding, and gene transcription. Taken together, our results indicate that pure WA or WA-enriched WS extracts can be considered as a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or cancer. [less ▲]

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See detailGlucocorticoids Modulate Tumor Radiation Response through a Decrease in Tumor Oxygen Consumption
Crokart, Nathalie; JORDAN, Bénédicte; BAUDELET, Christine et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (2007), 15(13), 6305

Purpose: We hypothesized that glucocorticoids may enhance tumor radiosensitivity by increasing tumor oxygenation (pO2) through inhibition of mitochondrial respiration. <br /> <br />Experimental Design ... [more ▼]

Purpose: We hypothesized that glucocorticoids may enhance tumor radiosensitivity by increasing tumor oxygenation (pO2) through inhibition of mitochondrial respiration. <br /> <br />Experimental Design: The effect of three glucocorticoids (hydrocortisone, dexamethasone, and prednisolone) on pO2 was studied in murine TLT liver tumors and FSaII fibrosarcomas. At the time of maximum pO2 (tmax, 30 min after administration), perfusion, oxygen consumption, and radiation sensitivity were studied. Local pO2 measurements were done using electron paramagnetic resonance. The oxygen consumption rate of tumor cells after in vivo glucocorticoid administration was measured using high-frequency electron paramagnetic resonance. Tumor perfusion and permeability measurements were assessed by dynamic contrast-enhanced magnetic resonance imaging. <br /> <br />Results: All glucocorticoids tested caused a rapid increase in pO2. At tmax, tumor perfusion decreased, indicating that the increase in pO2 was not caused by an increase in oxygen supply. Also at tmax, global oxygen consumption decreased. When irradiation (25 Gy) was applied at tmax, the tumor radiosensitivity was enhanced (regrowth delay increased by a factor of 1.7). <br /> <br />Conclusion: These results show the potential usefulness of the administration of glucocorticoids before irradiation. [less ▲]

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See detailInfluence of purified dietary fibre on bacterial protein synthesis in the large intestine of pigs, as measured by the gas production technique.
Bindelle, Jérôme ULg; Buldgen, André; Michaux, David et al

in Livestock Science (2007), 109

Microbial fermentation of non-digestible carbohydrates in the pig's large intestine induces a shift of N excretion from urea in urine to bacterial protein in faeces. Experiments were carried out to ... [more ▼]

Microbial fermentation of non-digestible carbohydrates in the pig's large intestine induces a shift of N excretion from urea in urine to bacterial protein in faeces. Experiments were carried out to measure the mineral N incorporation by the pig intestinal microflora using 5 purified carbohydrates in a gas-test: starch (S), cellulose (C), inulin (I), pectin (P) and xylan (X). Fermentation kinetics was modelled. N source in the buffer solution was replaced by 15N labelled NH4Cl. The bacterial N fixation was determined at mid-fermentation, measuring 15N incorporation into the solid phase of the buffer. The bacterial N fixation was higher (Pb0.001) with I and S (19.9 and 18.1 mg N/g incubated DM), compared to P, C and X (8.7, 5.9 and 5.5 respectively). Inulin and S were fermented also more rapidly, even if I (0.081 h−1) and C (0.074 h−1) showed lower half time fractional rate of degradation than S (0.153 h−1), P (0.133 h−1) and X (0.104 h−1). The insoluble dietary fibre content of the substrates was negatively correlated to bacterial N fixation (r=−0.957, P=0.011). The high crude protein content of P (32.5 mg g−1DM) might explain the lower impact of this substrate on bacterial N fixation, despite its rapid fermentation. Beside the proportion of insoluble fibre, the N content and the rate of fermentation seem to be the major factors influencing bacterial protein synthesis. Further studies including ingredients with variable content of indigestible protein and mean retention time in the pig's intestines are necessary. [less ▲]

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See detailSound production mechanism in the clownfish Amphiprion clarkii (Amphiprioninae, Pomacentridae)
Colleye, Orphal ULg; Herrel, Anthony; Mauguit, Quentin et al

Poster (2007)

Clownfishes live in social group within sea anemones. They are prolific “singers” that produce a wide variety of sounds, described as “pops” and “chirps”, involved in both reproductive and agonistic ... [more ▼]

Clownfishes live in social group within sea anemones. They are prolific “singers” that produce a wide variety of sounds, described as “pops” and “chirps”, involved in both reproductive and agonistic interactions. Although clownfish sounds were recorded since 1930, the mechanism of sound production has remained unresolved. The sounds used to describe the sonic mechanism were directed towards hetero- and conspecifics that approach their sea anemone host. Sound recordings were synchronized using a high speed video (500 fps) coupled or not with an X-ray system. These systems allowed to quantify the movements of external and internal bones during sound production. Sounds were typically accompanied by rapid (< 30 ms) head movements such as elevation of the skull, lowering of the hyoid bar and the anterior part of the branchial basket, retraction of the pectoral girdle, and finally closing of the mouth. Synchronization of sound pulses with X-ray images indicates that sound is produced when the hyoid apparatus is completely lowered and the mouth closed by a previously unknown mechanism. Dissections of freshly dead specimens reveal an unusual ligament responsible for the rapid mouth closing. This ligament joins the hyoid bar to the internal part of the mandible. Acting as a cord, it forces the mandible to turn around its articulation during the lowering of the anterior part of the branchial basket, forcing the mouth to close. Sounds result from the collision of the jaw teeth, transferring energy to the jaws that are presumably the sound radiator. [less ▲]

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See detailSeparate And Combined Disruptions Of Two Exo-Beta-1,3-Glucanase Genes Decrease The Efficiency Of Pichia Anomala (Strain K) Biocontrol Against Botrytis Cinerea On Apple
Friel, D.; Pessoa, Nmg.; Vandenbol, Micheline ULg et al

in Molecular Plant-Microbe Interactions [=MPMI] (2007), 20(4), 371-379

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See detailEffect Of Inoculum And Pepsin-Pancreatin Hydrolysis On Fibre Fermentation Mecasured By The Gas Production Technique In Pigs
Bindelle, Jérôme ULg; Buldgen, André; Boudry, Christelle ULg et al

in Animal Feed Science & Technology (2007), 132(1-2), 111-122

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See detailActualités dans le traitement des pseudarthroses aseptiques
Van Cauwenberge, Henry ULg; Hauzeur, Jean-Philippe ULg; Gillet, Philippe ULg

in Revue Médicale de Liège (2007), 62(5-6), 344-351

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See detailComment on: Long term actuarial survivorship analysis of an interspinous stabilization system (J Senegas et al.)
Gillet, Philippe ULg

in European Spine Journal (2007), 16(8), 1289-1290

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See detailFrasnian coral- stromatoporoid-microbial atolls, Belgium
Boulvain, Frédéric ULg

in Vennin, E.; Aretz, M.; Boulvain, Frédéric (Eds.) et al Facies from Palaeozoic reefs and bioaccumulations (2007)

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See detailEffect Of Bovine Colostrum Supplementation On Cytokine mRNA Expression In Weaned Piglets
Boudry, Christelle ULg; Buldgen, André; Portetelle, Daniel ULg et al

in Livestock Science (2007), 108(1-3), 295-298

The aim of this study was to evaluate the influence of a bovine colostrum supplementation on the immune Th1/Th2 response in weaned piglets. After weaning at 21 days, 21 piglets were fed daily ad libitum ... [more ▼]

The aim of this study was to evaluate the influence of a bovine colostrum supplementation on the immune Th1/Th2 response in weaned piglets. After weaning at 21 days, 21 piglets were fed daily ad libitum with a starter diet supplemented for 3 weeks with 0, 1 or 5 g of bovine colostrum. Growth performances were measured weekly. Spleen and gut-associated lymphoid tissues (GALT) (ileal Peyer’s patch (iPP), jejunum wall (JW) and mesenteric lymph nodes (MLN)) biopsies were collected on each piglet after the 3 weeks treatment and analyzed for their cytokine mRNA expression (IL-2, IL-4, IL-10, IL-12 and IFN) by RT-PCR. Growth performances were not affected by bovine colostrum (P > 0.05). In the colostrum groups, the iPP cells showed higher IL-4, IL-10 and IL-12 cytokine levels (P < 0,05), associated with a decrease of IFN-γ (P < 0,01) and no effect on IL-2 production (P > 0,05). IL-10, IL-2 and IL-12 productions increased (P < 0,05) in MLN, with no effect on IFN-γ and IL-4 levels (P > 0,05). The IL-12 production was also increased (P < 0,01) in JW cells with no modification for the other cytokine. No modification of cytokine production was observed in the spleen (P > 0,05). These results suggest an immunomodulatory effect of bovine colostrum on the GALT which answered by producing, at different levels, both Th1 pro-inflammatory cytokines - IL-2, IFN-γ and IL-12 - and Th2 anti-inflammatory cytokines - IL-4 and IL-10. This bipolarity of the Th1/Th2 response protects the weaned piglets from both allergic (food) as well as infectious (pathogens) diseases. [less ▲]

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See detailNonlinear regression with censored data
Heuchenne, Cédric ULg; Van Keilegom, Ingrid

in Technometrics (2007), 49(1), 34-44

Suppose that the random vector (X, Y) satisfies the regression model Y = m(X) + sigma(X)epsilon, where m(.) = E(Y vertical bar.) belongs to some parametric class (m(theta)(.):theta is an element of Theta ... [more ▼]

Suppose that the random vector (X, Y) satisfies the regression model Y = m(X) + sigma(X)epsilon, where m(.) = E(Y vertical bar.) belongs to some parametric class (m(theta)(.):theta is an element of Theta) of regression functions, sigma(2)(.) = var(Y vertical bar.) is unknown, and e is independent of X. The response Y is subject to random right censoring, and the covariate X is completely observed. A new estimation procedure for the true, unknown parameter vector theta(0) is proposed that extends the classical least squares procedure for nonlinear regression to the case where the response is subject to censoring. The consistency and asymptotic normality of the proposed estimator are established. The estimator is compared through simulations with an estimator proposed by Stute in 1999, and both methods are also applied to a fatigue life dataset of strain-controlled materials. [less ▲]

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See detailPsychanalyse et psychothérapie psychanalytique
Naziri, Despina ULg

Conference (2007)

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See detailSepsis is associated with an upregulation of functional beta3 adrenoceptors in the myocardium.
Moniotte, S.; Belge, C.; Sekkali, B. et al

in European Journal of Heart Failure : Journal of the Working Group on Heart Failure of the European Society of Cardiology (2007), 9(12), 1163-71

OBJECTIVE: To analyze the implication of the beta3-adrenoceptor (beta3-AR) pathway in human septic myocardium and a murine model of sepsis, a condition associated with myocardial depression. METHODS AND ... [more ▼]

OBJECTIVE: To analyze the implication of the beta3-adrenoceptor (beta3-AR) pathway in human septic myocardium and a murine model of sepsis, a condition associated with myocardial depression. METHODS AND RESULTS: beta3-AR and eNOS protein abundance were increased (332+/-66.4% and 218+/-39.3; P<0.05) in hearts from septic patients. The effect of BRL37344, a beta3-AR-preferential agonist, was analyzed by videomicroscopy on the contractility of neonatal mouse ventricular myocytes (NMVM) incubated with conditioned medium from LPS-stimulated cultured macrophages (Mc-LPS+ medium). Stimulation of untreated NMVM with BRL37344 dose-dependently decreased the amplitude of contractile shortening (P<0.05). This response was abolished by L-NAME (NOS inhibitor). Incubation in Mc-LPS+ medium potentiated the depressing effect of BRL37344 (P<0.05) as well as of SR58611A (P<0.05) in wild-type myocytes. Importantly, the contractile depression was abrogated in cardiomyocytes from beta3-AR KO mice. CONCLUSIONS: beta3-AR are upregulated during sepsis in the human myocardium and by cytokines in murine cardiomyocytes, where they mediate an increased negative inotropic response to beta3 agonists. Activation of the beta3-AR pathway by catecholamines may contribute to the myocardial dysfunction in sepsis. [less ▲]

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See detaileCole - Projet d'apprentissage et de remédiation en ligne
Vreeswijk, Valérie ULg; Javaux, Hubert; Reegers, Thésèse et al

Report (2007)

Recherche-développement consacrée à la conception d'un dispositif en ligne susceptible de soutenir l'autonomisation des apprenants dans le déploiement des compétences lire et écrire en français.

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See detailElectrothérapie. Electrostimulation.
Crepon, F.; DOUBRERE, J. F.; Vanderthommen, Marc ULg et al

in Encyclopédie médico-chirurgicale (EMC) (2007)

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See detailInvasion by Fallopia japonica increases topsoil mineral nutrient concentrations
Dassonville, Nicolas; Vanderhoeven, SONIA ULg; Gruber, Wolf et al

in Ecoscience (2007), 14(2), 230-240

Fallopia japonica is one of the most troublesome alien invasive plants across temperate regions, with large negative impacts on plant species diversity. We examined its impacts on topsoil chemistry and ... [more ▼]

Fallopia japonica is one of the most troublesome alien invasive plants across temperate regions, with large negative impacts on plant species diversity. We examined its impacts on topsoil chemistry and nutrient stocks in standing biomass at 6 sites with contrasting resident plant communities in Belgium. Topsoil and biomass were sampled in invaded and closely adjacent uninvaded plots. Standing biomass and mineral nutrient concentrations in soil (ammonium acetate exchangeable cations and P, total C, and N) and plants were determined. Soil under F. japonica generally had higher exchangeable nutrient concentrations (Cu: +45%, K: +34%, Mg: +49%, Mn: +61%, P: +44%, Zn: +75%). Standing biomass was 3- to 13-fold higher depending on site. Despite lower nutrient concentrations in aboveground biomass, invaded stands had 3.2- to 5.4-fold larger nutrient stocks in aboveground biomass compared to the resident vegetation. We conclude that F. japonica enhances nutrient cycling rates and topsoil fertility, probably due to nutrient uplift. The impacts were greatest in sites with low nutrient concentrations in uninvaded plots, suggesting that F. japonica may contribute to soil homogenization in invaded landscapes. [less ▲]

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See detailAspects psychiatriques en matière de syndrome fibromyalgique
Triffaux, Jean-Marc ULg; delpire, m; troisfontaines, b

in Acta Psychiatrica Belgica (2007)

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See detailThermomechanical one-phase modeling of semi-solid thixoforming
Koeune, Roxane ULg; Ponthot, Jean-Philippe ULg

in Int. Conf. on Computational Methods for Coupled Problems in Science and Engineering, COUPLED PROBLEMS 2007 (2007)

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See detailThe report and the command. The case for a relational perspective in the study of human and animal communication
Servais, Véronique ULg

in Intellectica (2007), 2-3(46-47), 85-104

ABSTRACT: The paper examines what it means to adopt a relational perspective in the study of animal and human communication. First it states that the informational view which dominates the study of animal ... [more ▼]

ABSTRACT: The paper examines what it means to adopt a relational perspective in the study of animal and human communication. First it states that the informational view which dominates the study of animal communication leads to cut apart the biological, the cognitive and the social parts of social communication. When it comes to human nonverbal communication, it is difficult then to articulate its biological and the cul¬tural dimensions. Following Ingold I argue that in order to go beyond the “natural pattern vs cultural rules or meaning” conception of human nonverbal communication, we need to rely on a relational view. But what is a relational view in the study of communication? In the final part of the paper, I suggest that social relationships are both subjective and objective entities and, drawing on an original paper by Kaufmann and Clément (2008, in press), I offer a hypothesis on how social communication could operate to objectively and subjectively organize the construction of social relationships. [less ▲]

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