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See detailNumerical study to identify the material parameters of a damage model
Schwartz, Renée ULg; Castagne, Sylvie; Habraken, Anne ULg

in Computer Methods in Materials Science (2007), 7(2), 237-242

In the continuous casting (CC) process, transversal cracks happen. This type of macroscopic damage is due to the process loading in the bending and unbending area of the CC line. In order to study this ... [more ▼]

In the continuous casting (CC) process, transversal cracks happen. This type of macroscopic damage is due to the process loading in the bending and unbending area of the CC line. In order to study this damage, a 2D model was developed. It simulates the intergranular crack at the mesoscopic level. Already validated for a microalloyed steel with C level < 0.1 wt%, this model must be extended to peritectic and stainless steels. The first step is to identify the model parameters for these grades. The type and the quantity of hot tensile tests required to identify a single set of parameters for the damage law must be determined. So, simulations of hot tensile tests of notched samples are needed. The computed stress and strain histories are applied on the representative mesoscopic cell and the moment of rupture is determined in function of the input parameters. Thanks to inverse modelling, the parameters of the damage law are adapted in order to get one single set of parameters with only two different geometries of notch. [less ▲]

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See detailRésumé CEDH, 10 octobre 2006, Pessino c/ France
Delnoy, Michel ULg

in Aménagement - Environnement (2007), 2

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See detailValidation of a new finite element for incremental forming simulation using a dynamic explicit approach
Henrard, Christophe ULg; Bouffioux, Chantal ULg; Duchene, Laurent ULg et al

in Key Engineering Materials [=KEM] (2007), 344

A new method for modeling the contact between the tool and the metal sheet for the incremental forming process was developed based on a dynamic explicit time integration scheme. The main advantage of this ... [more ▼]

A new method for modeling the contact between the tool and the metal sheet for the incremental forming process was developed based on a dynamic explicit time integration scheme. The main advantage of this method is that it uses the actual contact location instead of fixed positions, e.g. integration or nodal points. The purpose of this article is to compare the efficiency of the new method, as far as accuracy and computation time are concerned, with finite element simulations using a classic static implicit approach. In addition, a sensitivity analysis of the mesh density will show that bigger elements can be used with the new method compared to those used in classic simulations. [less ▲]

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See detailConsidering the effects of localised fires in the numerical analysis of a building structure
Franssen, Jean-Marc ULg; Pintea, Dan; Dotreppe, Jean-Claude ULg

in Fire Safety Journal (2007), 42(6-7, SEP-OCT), 473-481

The methodologies that are used for analysing the fire behaviour of a structure that is subjected to a uniform thermal situation cannot be applied when the fire is localised. The concept of "zoning" can ... [more ▼]

The methodologies that are used for analysing the fire behaviour of a structure that is subjected to a uniform thermal situation cannot be applied when the fire is localised. The concept of "zoning" can be applied: the structure is divided into several zones in which the situation is approximated as uniform. It is shown here that this division can lead to spurious forces in the structure. The structural code of the first author has been adapted in order to accommodate a continuous spatial variation of the fire environment. A series of uncoupled 2D thermal analyses is performed along the length of the beam finite elements and a series of ID thermal analyses is performed across the thickness of the shell finite elements. After a discussion of the concept and the particularities dictated by the continuous thermal environment, the methodology utilised is explained and is shown in an example consisting of a composite steel concrete car park subjected to a localised fire of the type given in Eurocode 1. (C) 2007 Elsevier Ltd. All rights reserved. [less ▲]

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See detailParametric conditional mean and variance testing with censored data
Heuchenne, Cédric ULg; González Manteiga, Wenceslao; Sánchez Sellero, Cesar

in H. Skiadas, Christos (Ed.) Recent Advances in Applied Stochastic Models and Data Analysis. (2007)

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See detailSperm quality and cryopreservation in Perca fluviatilis
Linhart, Ottomar; Alavi Hadi, S. M.; Rodina, M. et al

Conference (2007)

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See detailBelgium : Characteristics of International Administration in Crisis Area
Candela Soriano, Mercedes; Brunet, Sébastien ULg

in Korhonen, Outi (Ed.) International Administration of Crisis Area : Nine National Approaches (2007)

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See detailRespiratory distress syndrome in full-term newborn calves
Rollin, Frédéric ULg; Danlois, Fabien; Aliaoui, Hamani et al

Conference (2007)

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See detailCell dynamics and immune response to BLV infection: a unifying model
Florins, Arnaud-Francois ULg; Gillet, Nicolas ULg; Asquith, Becca et al

in Frontiers in Bioscience : A Journal and Virtual Library (2007), 12

Bovine Leukemia virus (BLV) is the natural etiological agent of a lymphoproliferative disease in cattle. BLV can also be transmitted experimentally to a related ruminant species, sheep, in which the ... [more ▼]

Bovine Leukemia virus (BLV) is the natural etiological agent of a lymphoproliferative disease in cattle. BLV can also be transmitted experimentally to a related ruminant species, sheep, in which the pathogenesis is more acute. Although both susceptible species develop a strong anti-viral immune response, the virus persists indefinitely throughout life, apparently at a transcriptionally silent stage, at least in a proportion of infected cells. Soon after infection, these humoral and cytotoxic activities very efficiently abolish the viral replicative cycle, permitting only mitotic expansion of provirus-carrying cells. Short term cultures of these infected cells initially indicated that viral expression protects against spontaneous apoptosis, suggesting that leukemia is a process of accumulation of long-lived cells. This conclusion was recently reconsidered following in vivo dynamic studies based on perfusions of nucleoside (bromodeoxyuridine) or fluorescent protein markers (CFSE). In sheep, the turnover rate of infected cells is increased, suggesting that a permanent clearance process is exerted by the immune system. Lymphocyte trafficking from and to the secondary lymphoid organs is a key component in the maintenance of cell homeostasis. The net outcome of the immune selective pressure is that only cells in which the virus is transcriptionally silenced survive and accumulate, ultimately leading to lymphocytosis. Activation of viral and/or cellular expression in this silent reservoir with deacetylase inhibitors causes the collapse of the proviral loads. In other words, modulation of viral expression appears to be curative in lymphocytic sheep, an approach that might also be efficient in patients infected with the related Human T-lymphotropic virus type 1. In summary, a dynamic interplay between BLV and the host immune response modulates a complex equilibrium between (i) viral expression driving (or) favoring proliferation and (ii) viral silencing preventing apoptosis. As conclusion, we propose a hypothetical model unifying all these mechanisms. [less ▲]

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See detailClinical Protection against Caprine Herpesvirus 1 Genital Infection by Intranasal Administration of a Live Attenuated Glycoprotein E Negative Bovine Herpesvirus 1 Vaccine
Thiry, Julien ULg; Tempesta, M.; Camero, M. et al

in BMC Veterinary Research (2007), 3

BACKGROUND: Caprine herpesvirus 1 (CpHV-1) is responsible of systemic diseases in kids and genital diseases leading to abortions in goats. CpHV-1 is widespread and especially in Mediterranean countries as ... [more ▼]

BACKGROUND: Caprine herpesvirus 1 (CpHV-1) is responsible of systemic diseases in kids and genital diseases leading to abortions in goats. CpHV-1 is widespread and especially in Mediterranean countries as Greece, Italy and Spain. CpHV-1 is antigenically and genetically closely related to bovine herpesvirus 1 (BoHV-1). Taking into account the biological properties shared by these two viruses, we decided in the current study to assess the protection of a live attenuated glycoprotein E (gE) negative BoHV-1 vaccine against a genital CpHV-1 infection in goats. RESULTS: The vaccine was inoculated intranasally twice three weeks apart followed by a subsequent CpHV-1 intravaginal challenge which is the natural route of infection in three goats. To analyse the safety and the efficacy of this marker vaccine, two groups of three goats served as controls: one immunised with a virulent CpHV-1 and one uninoculated until the challenge. Goats were clinically monitored and all sampling procedures were carried out in a blind manner. The vaccine did not induce any undesirable local or systemic reaction and goats did not excrete gE-negative BoHV-1. After challenge, a significant reduction in disease severity was observed in immunised goats. Moreover, goats immunised with either gE-negative BoHV-1 or CpHV-1 exhibited a significant reduction in the length and the peak of viral excretion. Antibodies neutralising both BoHV-1 and CpHV-1 were raised in immunised goats. CONCLUSION: Intranasal application of a live attenuated gE-negative BoHV-1 vaccine is able to afford a clinical protection and a reduction of virus excretion in goats challenged by a CpHV-1 genital infection. [less ▲]

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See detailMise en place d’une session d’interrogations formatives au mois de novembre: impact sur la motivation et les performances ultérieures des étudiants
Mignon, Jacques ULg; Closset, Jean-Louis ULg

in Actes du 24e congrès de l’Association internationale de pédagogie universitaire (AIPU) (2007)

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See detailPeut-on lutter contre l'échec scolaire ? (3e éd.)
Crahay, Marcel ULg

Book published by De Boeck (2007)

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See detailEquity of achievement : A matter of education structures ?
Baye, Ariane ULg; Monseur, Christian ULg

in The Second IEA International Research Conference : Proceedings of the IRC-2006 (2007)

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See detailAn Ageing Burden Indicator
Lefebvre, Mathieu ULg; Perelman, Sergio ULg

in Marin, B.; Zaidi, A. (Eds.) Mainstreaming Ageing. Indicators to Monitor Sustainable Policies (2007)

In this chapter we propose a simple framework to compute a burden indicator to be used in the ageing sustainability debate. Relying on the projections of population as well as on the employment rate and ... [more ▼]

In this chapter we propose a simple framework to compute a burden indicator to be used in the ageing sustainability debate. Relying on the projections of population as well as on the employment rate and the generosity of the systems, it offers the possibility to anticipate the main reforms to be accomplished in order to share the burden of the pay-as-you-go schemes between generations [less ▲]

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See detailA tumormozgások jelentôségének sokszeletes-CT-alapú képfúziós vizsgálata tüdôdaganatos betegek sugárkezelésénél
Kovács, Árpád; Hadjiev, Janaki; LAKOSI, Ferenc ULg et al

in Magyar Onkologia (2007), 51(3), 219-223

The aim of our study was to detect the possible uncertainties arising from tumor movements in the daily routine treatment planning, in extreme breathing conditions. Ten patients with lung cancer were ... [more ▼]

The aim of our study was to detect the possible uncertainties arising from tumor movements in the daily routine treatment planning, in extreme breathing conditions. Ten patients with lung cancer were enrolled into the study. According to tumor location, five patients had peripheral and five had central tumor. After the normal planning CT scan, two more scans were made with the same CT parameters in maximal exhalation and in maximal inhalation. For planning, the normal breathing scans were used with the fusion of the maximal inhalation and maximal exhalation scans. After the fusion in all breathing phases the gross tumor volumes were contoured (GTV1, GTV2, GTV3). Around the GTV1 (normal breathing phase GTV) 3 planning target volumes (PTV) were generated with the margin of 0.5 cm, 1.5 cm and 2.5 cm (PTV1, PTV2, PTV3). Individual plans were generated to all PTVs. All GTV volumes were registered. In all cases volume deviations were registered in different breathing phases (min: 1.5%, max: 35.6%). For GTV coverage comparison the coverage index (CI) was used. In case of extreme breathing conditions, using 0.5 cm margin was sufficient to reach good coverage for central tumors. For peripheral tumors 1.5 cm margin had to be used for the acceptable coverage (CI: 0.85-1.00). In our study, extreme breathing conditions were analyzed. According to our results, CT scans used in the daily routine do not exactly represent the tumor midposition and the true tumor volume. Due to breathing synchronous tumor movements, 0.5 cm margin must be used for planning in central location. In peripheral tumors wider margin should be used. [less ▲]

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See detailPotential Physical And Chemical Barriers To Infection By The Burrowing Nematode Radopholus Similis In Roots Of Susceptible And Resistant Banana (Musa Spp.)
Wuyts, Nathalie; Lognay, Georges ULg; Verscheure, Marjolaine et al

in Plant Pathology (2007), 56(5), 878-890

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See detailOxygen mass transfer in a biphasic medium: Influence on the biotransformation of methyl ricinoleate into γ-decalactone by the yeast Yarrowia lipolytica
Gomes, N.; Aguedo, Mario ULg; Teixeira, J. et al

in Biochemical Engineering Journal (2007), 35(3), 380-386

In this work, an empirical correlation is proposed to describe kLa as a function of operating conditions (agitation and aeration rates) and of oil and surfactant volumetric fractions in a ... [more ▼]

In this work, an empirical correlation is proposed to describe kLa as a function of operating conditions (agitation and aeration rates) and of oil and surfactant volumetric fractions in a biotransformation medium, an oil-in-water dispersion. An interaction effect between the oil and the surfactant effects was found, since oil presence increased kLa in the absence of the surfactant but had an opposite effect when Tween 80 was available in the medium. The biotransformation of methyl ricinoleate (MR) into γ-decalactone (an aroma compound of industrial interest), by the yeast Yarrowia lipolytica, was carried out at different conditions of operation, to evaluate the influence of kLa on the production of the aroma. It was demonstrated that kLa had an influence on the aroma production; however, for the low hydrophobic substrate concentration used (1.08% v/v) and cellular density of 2.0 × 107 cells mL-1, a minimal kLa value of 70 h-1 was necessary to attain the maximal aroma production. © 2007 Elsevier B.V. All rights reserved. [less ▲]

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