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See detailNumerical modelling of the hydrogeological and geomechanical behaviour of a large slope movement: The Triesenberg landslide (Liechtenstein).
François, Bertrand ULg; Tacher, Laurent; Bonnard, Christophe et al

in Canadian Geotechnical Journal (2007), 44(7), 840-857

Using advanced hydrogeological and geomechanical finite element modelling, it has been possible to model the mechanical behaviour of a large slope movement, the Triesenberg landslide. This slope is ... [more ▼]

Using advanced hydrogeological and geomechanical finite element modelling, it has been possible to model the mechanical behaviour of a large slope movement, the Triesenberg landslide. This slope is located along the Rhine valley in the Principality of Liechtenstein and covers an area of around 5 km(2), which includes two villages. Pore-water pressure fields calculated by the hydrogeological model were used as input for the geomechanical model. The results obtained through numerical simulation agree fairly well with field measurements of peak velocity, spatial and temporal distribution of velocity, and total displacements. Such results were obtained using a modified Cam-Clay elastoplastic constitutive model for which the required material parameters were obtained through careful geotechnical tests. These finite element models were carried out in two and three dimensions to gradually improve the understanding of the physical phenomena governing the hydrogeological conditions and the movements of the slope. [less ▲]

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See detailL'image du mois. Onychopathie mycopsoriasique.
Franchimont, Claudine ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2007), 62(9), 533

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See detailSepsis is associated with an upregulation of functional beta3 adrenoceptors in the myocardium.
Moniotte, S.; Belge, C.; Sekkali, B. et al

in European Journal of Heart Failure : Journal of the Working Group on Heart Failure of the European Society of Cardiology (2007), 9(12), 1163-71

OBJECTIVE: To analyze the implication of the beta3-adrenoceptor (beta3-AR) pathway in human septic myocardium and a murine model of sepsis, a condition associated with myocardial depression. METHODS AND ... [more ▼]

OBJECTIVE: To analyze the implication of the beta3-adrenoceptor (beta3-AR) pathway in human septic myocardium and a murine model of sepsis, a condition associated with myocardial depression. METHODS AND RESULTS: beta3-AR and eNOS protein abundance were increased (332+/-66.4% and 218+/-39.3; P<0.05) in hearts from septic patients. The effect of BRL37344, a beta3-AR-preferential agonist, was analyzed by videomicroscopy on the contractility of neonatal mouse ventricular myocytes (NMVM) incubated with conditioned medium from LPS-stimulated cultured macrophages (Mc-LPS+ medium). Stimulation of untreated NMVM with BRL37344 dose-dependently decreased the amplitude of contractile shortening (P<0.05). This response was abolished by L-NAME (NOS inhibitor). Incubation in Mc-LPS+ medium potentiated the depressing effect of BRL37344 (P<0.05) as well as of SR58611A (P<0.05) in wild-type myocytes. Importantly, the contractile depression was abrogated in cardiomyocytes from beta3-AR KO mice. CONCLUSIONS: beta3-AR are upregulated during sepsis in the human myocardium and by cytokines in murine cardiomyocytes, where they mediate an increased negative inotropic response to beta3 agonists. Activation of the beta3-AR pathway by catecholamines may contribute to the myocardial dysfunction in sepsis. [less ▲]

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See detailContribution of cyclodextrins in the developement of different pharmaceutical formulations of a nex matrix metalloproteinase inhibitor
Evrard, Brigitte ULg; Bertholet, Pascal; Guéders, Maud ULg et al

in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry (2007), 57(1-4), 303-308

Ro 28-2653 is a new synthetic inhibitor of matrix metalloproteinases. The ability of these enzymes to degrade various components of the extracellular matrix seems to play a major role in tumors ... [more ▼]

Ro 28-2653 is a new synthetic inhibitor of matrix metalloproteinases. The ability of these enzymes to degrade various components of the extracellular matrix seems to play a major role in tumors progression and is potentially effective against bronchial remodeling in asthma and BPCO. Ro 28-2653 is very poorly soluble in water. This low solubility estimated at about 0.56 lg/ml in water at 25 C gives rise to difficulties in pharmaceutical formulation of oral, injectable or <br />nebulizable solutions. The purpose of our study is to prepare and to characterize inclusion complexes between Ro 28-2653 and cyclodextrins and to investigate the biopharmaceutical repercussion of the inclusion of the active substance.The complex formation was investigated by phase solubility studies. 1H-NMR spectroscopy and molecular modeling studies were carried out to elucidate the structure of the inclusion <br />complex between Ro 28-2653 and cyclodextrin. Oral, intravenous and nebulizable solutions of Ro 28-2653 were developed with cyclodextrin. The in vivo studies were performed on healthy sheep for the pharmacokinetic evaluation of the oral and intravenous formulations while the nebulization of the complex solution was studied by using an asthma model in mouse. [less ▲]

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See detailOxygen consumption of equine articular chondrocytes: Influence of applied oxygen tension and glucose concentration during culture.
Schneider, Nicole ULg; Mouithys-Mickalad, Ange ULg; Lejeune, Jean-Philippe ULg et al

in Cell Biology International (2007), 31

We investigated the oxygen (O2) uptake of equine articular chondrocytes to assess their reactions to anoxia/re-oxygenation. They were cultured under 5% or 21% gas phase O2 and at glucose concentrations of ... [more ▼]

We investigated the oxygen (O2) uptake of equine articular chondrocytes to assess their reactions to anoxia/re-oxygenation. They were cultured under 5% or 21% gas phase O2 and at glucose concentrations of 0, 1.0 or 4.5 g/L in the culture medium (n = 3). Afterwards, the O2 consumption rate of the chondrocytes was monitored (oxymetry) before and after an anoxia period of 25 min. The glucose consumption and lactate release were measured at the end of the re-oxygenation period. The chondrocytes showed a minimal O2 consumption rate, which was hardly changed by anoxia. Independently from the O2 tension, glucose uptake by the cells was about 30% of the available culture medium glucose, thus higher for cells at 4.5 g/L glucose (n = 3). Lactate release was also independent from O2 tension, but lower for cells at 4.5 g/L glucose (n = 3). Our observations indicated that O2 consumption by equine chondrocytes was very low despite a functional mitochondrial respiratory chain, and nearly insensitive to anoxia/re-oxygenation. But the chondrocytes metabolism was modified by an excess of O2 and glucose. [less ▲]

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See detailPratiques de la lecture, de l'écriture et du calcul dans le milieu professionnel et à domicile
Hindryckx, Geneviève ULg; Baye, Ariane ULg; Crepin, Françoise ULg

in Journal de l'alpha (2007), 159(juillet-août), 88-95

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See detailNon-invasive assessment of airway responsiveness in healthy and allergen-sensitised cats by use of barometric whole body plethysmography
Kirschvink, N.; Leemans, Jérôme ULg; Delvaux, François et al

in Veterinary Journal (2007), 173(2), 343-352

This study aimed at determining whether airway responsiveness (AR) tests performed by use of barometric whole body plethysmography (BWBP) were repeatable in cats and to what extent AR was affected by the ... [more ▼]

This study aimed at determining whether airway responsiveness (AR) tests performed by use of barometric whole body plethysmography (BWBP) were repeatable in cats and to what extent AR was affected by the nebulization protocol used, the age of the animals, the inflammatory status of the airways and prior bronchodilator treatment. Repeatability of AR was tested on two occasions in 30 healthy cats. The concentration of carbachol inducing a 300% increase of the enhanced pause (Penh) - an estimator of airflow limitation - was calculated (C-Penh300) and did not differ significantly between the two tests (0.035 +/- 0.017% compared to 0.034 +/- 0.016%) and was significantly and positively correlated. The comparison between rapidly and slowly increasing carbachol concentrations was performed in ten healthy cats and showed a significantly lower C-Penh300 (%) when slowly increasing concentrations were used (0.037 +/- 0.013% compared to 0.039 +/- 10.015%, P < 0.05). A significant age-related increase of C-Penh300 was evidenced by performing AR tests in 15 healthy cats at 12, 18, 24 and 30 months (12 months: 0.026 +/- 0.008%, 18 months: 0.031 +/- 0.009%, 24 months: 0.038 +/- 0.01%, 30 months: 0.043 +/- 0.014%, P < 0.05). C-Penh300 significantly decreased in 12 Ascaris suum-sensitised cats after allergen exposure (0.026 +/- 0.016% compared to 0.033 +/- 0.016%, P < 0.05) and was negatively correlated with the granulocyte percentage of bronchoalveolar lavage fluid (r = -0.36, P < 0.01). Compared with a placebo inhalation, pretreatment with inhaled salbutamol significantly increased C-Penh300 in four healthy cats (0.093 +/- 0.021% compared to 0.036 +/- 0.004%, P < 0.05). This study provides evidence that AR determination by use of BWBP is promising as non-invasive indicator of lower airway inflammation or for monitoring response to bronchodilator treatment. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailEffects of attention on emotional face processing in depression : a functional MRI study
Desseilles, Martin; Maquet, Pierre ULg; Dang Vu, Thien Thanh et al

Poster (2007)

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See detailDe la séparation des pouvoirs à l'espace public démocratique
Herla, Anne ULg

Article for general public (2007)

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See detailManipulation of the vortex motion in nanostructured ferromagnetic/superconductor hybrids
Silhanek, Alejandro ULg; Gillijns, W.; Moshchalkov, V. V. et al

in Applied Physics Letters (2007), 90(18),

The authors investigate the rectified motion of vortices in superconducting films deposited on top of a close-packed array of open in-plane magnetized triangular micromagnets. The dc voltage induced by ... [more ▼]

The authors investigate the rectified motion of vortices in superconducting films deposited on top of a close-packed array of open in-plane magnetized triangular micromagnets. The dc voltage induced by the vortex drift under an ac excitation is recorded for three different magnetic configurations of the triangles. When the magnetic elements are in the as-grown state a rectification signal which reverses sign when the field changes polarity is observed. In contrast to that, when the array of triangles is magnetized the observed rectification effect is independent of the field polarity and can be reverted by reorienting the magnetization of the micromagnets. (C) 2007 American Institute of Physics. [less ▲]

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See detailMechanical constitutive framework for thermal effects on unsaturated soils.
François, Bertrand ULg; Nuth, Mathieu; Laloui, Lyesse

in Proceeding of the 10th Int. Symp. on Numerical Models in Geomechanics, NUMOG X (2007)

Research interest in the thermo-mechanical behaviour of unsaturated soils is growing as a result of an increasing number of geomechanical problems involving both thermal and suction effects. The ... [more ▼]

Research interest in the thermo-mechanical behaviour of unsaturated soils is growing as a result of an increasing number of geomechanical problems involving both thermal and suction effects. The underground waste disposal is one such critical problem. Until now, these two environmental loadings have often been considered independently. This paper proposes a new unified thermo-mechanical framework for unsaturated soils based on thermo-hydro-mechanical (THM) experimental evidence on cohesive soils. The Bishop effective stress framework is adopted to represent the stress state in the soil in a unified fashion. This constitutive context based on the evolution of two key parameters (the preconsolidation pressure and the suction air-entry value) makes it possible to represent the main features of the thermo-mechanical behaviour of unsaturated soils. [less ▲]

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See detailA perturbation finite element method for modeling moving conductive and magnetic regions without remeshing
Dular, Patrick ULg; V Sabariego, Ruth ULg

in COMPEL (2007), 26(3), 700-711

Purpose - To develop a sub-domain perturbation technique for efficiently modeling moving systems in magnetodynamics with a magnetic field h-conform finite element (FE) formulation. Design/methodology ... [more ▼]

Purpose - To develop a sub-domain perturbation technique for efficiently modeling moving systems in magnetodynamics with a magnetic field h-conform finite element (FE) formulation. Design/methodology/approach - A reference problem is first solved in a global mesh excluding some moving regions and thus avoiding the inclusion of their meshes. Its solution gives the sources for a sequence of perturbation problems with the supplementary moving magnetic and conductive regions. Each of these sub-problems requires an appropriate proper volume mesh of the associated moving region and its surrounding region, with no need of interconnection. The solutions are transferred from one problem to the other through projections of source fields between meshes. Findings - The consideration of sub-problems and associated sources, in a sequence of perturbation problems, leads to a significant speed-up of the repetitive solutions in analyses of moving systems. A free movement in any direction can be considered with no need of remeshing. Originality/value - When working with the perturbation fields, the volume sources can be limited to the moving regions, what allows for homogeneous perturbation boundary conditions and reduces the computational efforts for projecting and evaluating the sources. The curl-conformity of the unknown magnetic field is preserved during the whole process thanks to the use of edge FEs for both the magnetic field and the intermediate source quantities. The sub-problem approach also gives an easy way to directly express the time derivatives in moving frames. [less ▲]

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See detailDigital Imaging
Verly, Jacques ULg

Scientific conference (2007)

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See detailGilles Hayne, le duc de Neuburg et Biagio Marini
Vendrix, Philippe ULg; Corswarem, Emilie ULg; Bianco, Aurelio

in Studi Musicali (2007), XXXVI(2), 363-441

Cet article consiste en l’édition commentée d’une abondante correspondance tenue entre l’un des compositeurs liégeois majeurs du XVIIe siècle, Gilles Hayne et son mécène, le comte palatin du Rhin et duc ... [more ▼]

Cet article consiste en l’édition commentée d’une abondante correspondance tenue entre l’un des compositeurs liégeois majeurs du XVIIe siècle, Gilles Hayne et son mécène, le comte palatin du Rhin et duc de Neubourg, Wolfgang-Wilhelm, figure importante de la vie politique et culturelle du Saint-Empire. Outre ses fonctions de Surintendant de la musique du duc, Hayne s’illustre comme Maître de chapelle du prince-évêque Ferdinand de Bavière, et comme Grand chantre de la collégiale Saint-Jean de Liège. La correspondance jette un éclairage sur le mécénat aristocratique durant les premières décennies du XVIIe siècle dans le Saint-Empire et sur les échanges noués entre Liège et le duché de Neubourg, l’un des rares îlots de relative quiétude en cette période pour la moins troublée. De nombreux artistes bénéficient du mécénat du duc de Neubourg, de van Dyck à Rubens, de Hayne à Biagio Marini, autre personnalité importante de l’Europe musicale mise en évidence par la correspondance. [less ▲]

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See detailMuscle energetics in exercising horses
Votion, Dominique ULg; Navet, Rachel ULg; Lacombe, A. et al

in Equine & Comparative Exercise Physiology (2007), 4

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See detailLocal Second Gradient Models and Damage Mechanics: 1D Post-Localization Studies in Concrete Specimens
Kotronis, Panagiotis; Collin, Frédéric ULg; Bésuelle, Pierre et al

in Exadaktylos, G.; Vardoulakis, Ioannis (Eds.) Bifurcations, Instabilities, Degradation in Geomechanics (2007)

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