References of "2007"
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See detailNovel dipyrazoles acting as glutamate modulators
Francotte, Pierre ULg; De Tullio, Pascal ULg; Pirotte, Bernard ULg

in Expert Opinion on Therapeutic Patents (2007), 17(12), 1489-1493

Knowing the potential therapeutic interest of AMPA potentiation, patents have been published for 15 years relating the discovery of novel compounds able to allosterically bind to the AMPA receptors and ... [more ▼]

Knowing the potential therapeutic interest of AMPA potentiation, patents have been published for 15 years relating the discovery of novel compounds able to allosterically bind to the AMPA receptors and leading to a potentiation of the AMPA signals. Besides this classical approach, a new target for the medicinal chemist has been defined due to the recent findings describing the modulation of AMPA receptors by neuronal proteins, and has led to the design of dipyrazole compounds by Aventis. These new dipyrazole derivatives may be considered as `indirect AMPApams', constituting a new pharmacological class. Based on their in vitro activity, it is probable that these compounds could be of therapeutic value for the treatment of cognitive disorders, schizophrenia or depression. [less ▲]

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See detailMercury in the blood of free ranging pinnipeds: levels, sources of variation, toxicocinetic and potential impact using an in vitro model
Das, Krishna ULg; De Pauw-Gillet, Marie-Claire ULg; Habran, Sarah ULg et al

Conference (2007)

Despite 30 years of international regulations, Hg levels in marine mammals have not decreased. Various environmental models even suggest a rise of mercury in the biota during the next decades, linked to ... [more ▼]

Despite 30 years of international regulations, Hg levels in marine mammals have not decreased. Various environmental models even suggest a rise of mercury in the biota during the next decades, linked to climate change. The objective of this study is (1) to assess Hg levels in blood samples of free-ranging pinnipeds, (2) to understand level variation during different periods of life (gestation, lactation, fasting) and potential impact on lymphocytes using a preliminary in vitro model (peripheral blood mononuclear cells, PBMC). Blood samples were collected from harbour seals (Phoca vitulina n= 22) from the North Sea and from elephant seals from the Californian coast (Mirounga angustirostris 12 females and 12 pups). Harbour seal PBMC were isolated, set in medium culture and contaminated with methyl-Hg (1 µM). Biological tests and proteomic assay were realized on control and contaminated PBMC. Hg levels were from the same order of magnitude for the two species despite two different lifestyles and habitats: from 40 to 590 ng.g-1 fw in harbour seal and from 63 to 919 ng.g-1 fw in elephant seal. Hg concentrations in the blood depend upon several factors such as body weight, fasting and lactation duration for mothers and pups. After 21 days of lactation, female elephant seals doubled their blood Hg levels (from 308 to 593 ng.g-1fw) while a decrease is observed for pups. This increase is linked to mobilization from blubber and muscle during fasting associated to lactation. Cell model revealed an in vitro effect of Hg even at low concentration (1µM). Number of PBMC, viability, metabolic activity, DNA and RNA synthesis were reduced in vitro suggesting deleterious effects of Hg in concentrations encountered in free-ranging pinnipeds. Knowing that Hg methylation in the ocean is linked to temperature, one can wonder on Hg levels (and effects) in pinnipeds during the next decades. [less ▲]

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See detailPROTEOMIC ANALYSIS OF WILD TYPE AND LUCIFERASE REPORTER HEPG2 CELLS EXPOSED TO TCDD
Lambert, Damien; Mazzucchelli, Gabriel ULg; De Pauw, Edwin ULg et al

in Organohalogen Compounds (2007), 69

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See detailPrésentation D-STAR - Micro-satellite (Leodium) & station radio-amateur ULg
Halbach, Luc; Verly, Jacques ULg

Scientific conference (2007)

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See detailPolymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease.
Georges, Michel ULg; Coppieters, Wouter ULg; Charlier, Carole ULg

in Current opinion in genetics & development (2007), 17(3), 166-76

The expression of at least a third of mammalian genes is post-transcriptionally fine-tuned by approximately 1000 microRNAs (miRNAs), assisted by the RNA silencing machinery, comprising tens of components ... [more ▼]

The expression of at least a third of mammalian genes is post-transcriptionally fine-tuned by approximately 1000 microRNAs (miRNAs), assisted by the RNA silencing machinery, comprising tens of components. Polymorphisms and mutations in the corresponding sequence space (machinery, miRNA precursors and target sites) are likely to make a significant contribution to phenotypic variation, including disease susceptibility. Here we review basic miRNA biology in animals, survey the available evidence for DNA sequence polymorphisms affecting miRNA-mediated gene regulation and thus phenotype, and discuss their possible importance in the determination of complex traits. [less ▲]

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See detailTime-domain homogenization of windings in 2-D finite element models
Gyselinck, Johan; V Sabariego, Ruth ULg; Dular, Patrick ULg

in IEEE Transactions on Magnetics (2007), 43(4), 1297-1300

In this paper, the authors propose an original time-domain extension of the frequency-domain homogenization of multiturn windings in finite element (FE) models. For the winding type in hand (e.g., round ... [more ▼]

In this paper, the authors propose an original time-domain extension of the frequency-domain homogenization of multiturn windings in finite element (FE) models. For the winding type in hand (e.g., round conductor with hexagonal packing), an elementary FE model is used for determining dimensionless frequency and time-domain coefficients regarding skin and proximity effect. These coefficients are readily utilized for homogenizing the winding in the FE model of the complete device. The method is successfully applied to an axisymmetric 103-turn inductor. The results agree very well with those obtained by an accurate but very expensive FE model in which all turns are finely discretized. [less ▲]

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See detailPlan stratégique
Pagnoulle, Christine ULg

in Durand, Pascal (Ed.) Les nouveaux mots du pouvoir, Abécédaire critique (2007)

This is but a very limited contribution to a major critical enterprise, a systematic debunking of smokescreen words such as governance, civil society or expertise.

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See detailAn introduction to reliability analysis
Denoël, Vincent ULg

Learning material (2007)

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See detailGRB070429B: VLT observations.
Antonelli, L. A.; Stella, L.; Tagliaferri, G. et al

in GRB Coordinates Network (2007), 6372

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See detailPatterns of diversification in early eukaryotes
Javaux, Emmanuelle ULg

in Steemans, Philippe; Javaux, Emmanuelle (Eds.) Recent advances in palynology (2007)

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See detailSimenon-Hergé, thirties
Denis, Benoît ULg

in Aubert, Nathalie; Fraiture, Pierre-Philippe; Mac Guiness, Patrick (Eds.) From Art Nouveau to Surrealism: Belgian Modernity in the making (2007)

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See detailLes sens de la présentation
Faulx, Daniel ULg; Coffani, Pascal

in Cahiers Internationaux de Psychologie Sociale (2007), 75-76

This structured experience addresses three goals: to allow the participants to introduce themselves to each other; to facilitate interpersonal sharing and, for sessions that specifically focus on ... [more ▼]

This structured experience addresses three goals: to allow the participants to introduce themselves to each other; to facilitate interpersonal sharing and, for sessions that specifically focus on creativity, to allow participants to reflect on the three-way relationship between oneself, a creation produced, and the audience at whom it is aimed. [less ▲]

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See detailLa rencontre des objets
Faulx, Daniel ULg; Delvaux, Sophie; Coffani, Pascal

in Cahiers Internationaux de Psychologie Sociale (2007), 75-76

This structured experience addresses four goals: to allow the participants to introduce themselves to each other; to facilitate interpersonal sharing; for the sessions focusing specifically on ... [more ▼]

This structured experience addresses four goals: to allow the participants to introduce themselves to each other; to facilitate interpersonal sharing; for the sessions focusing specifically on interpersonal relationships, to raise awareness of the different dimensions of interpersonal encounters; and finally, for the sessions focusing specifically on creativity, to foster reflection on the relationship between oneself, others, the work that is produced, and the audience to whom it is addressed. [less ▲]

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