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See detailExpertise ZAE II. Identification des localisations optimales des activités économiques
Lambotte, Jean-Marc ULg; Bastin, A.; Lepers, E. et al

Report (2007)

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See detailSur l'erreur résiduelle obtenue en régression linéaire multiple.
Akossou, A. Y. J.; Palm, Rodolphe ULg; Fonton, N. H. et al

Scientific conference (2007)

The residual error is one of the most used criteria for the choice of regression model. The large majority of the criteria for model selection are also functions of the usual variance estimate for a ... [more ▼]

The residual error is one of the most used criteria for the choice of regression model. The large majority of the criteria for model selection are also functions of the usual variance estimate for a regression model, as Akaike criterion information [Akaike, 1973] and Mallows’ criterion [Mallows, 1964]. The effectiveness of these criteria to approach the theoretical model is related to the good estimate of the theoretical residual error of the model. This efficiency is often limited by the sample size used for the estimates. The choice of a invalid model can have bad consequences on the objective of the research in particular on the forecasts, interpretations and the conclusions. We studied by Monte Carlo simulation the effects of the data structure on the quality of the residual error obtained in multiple linear regression. The results showed that the estimator is a good estimator when the model is established without selection of variables, but becomes biased when the model results from a selection of variables. Colinearity between the explanatory variables and the index which measure the importance of the variables in the true model do not have an influence on the quality of the estimator. [less ▲]

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See detailPerineal herpes simplex infection in bedridden geriatric patients.
Nikkels, Arjen ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2007), 8(2), 79-83

BACKGROUND: Herpes simplex virus (HSV) lesions are prone to reactivation and recurrence in response to various local or systemic triggering factors. OBJECTIVE: To study the characteristics of five ... [more ▼]

BACKGROUND: Herpes simplex virus (HSV) lesions are prone to reactivation and recurrence in response to various local or systemic triggering factors. OBJECTIVE: To study the characteristics of five bedridden geriatric patients who presented with herpetic recurrences on the buttocks, gluteal cleft, and perianal region during hospitalization. METHODS: Data were gathered regarding age, gender, reason for hospitalization, localization of lesions, clinical presentation, previous clinical diagnosis and topical treatments, immune status and immunosuppressant drug intake, as well as prior history of labial or genital herpes. A skin biopsy was taken for histologic examination and immunohistochemical viral identification. Viral culture and viral serology were performed and data regarding antiviral therapy were recorded. RESULTS: The five patients (three women, two men) were aged >80 years and hospitalized for either severe drug-induced renal insufficiency (one case), severe pneumonia (two cases), or stroke causing restricted mobility (two cases). Numerous well demarcated, painful ulcerations developed in the perianal region of these patients, and one patient also presented with some vesicular lesions. The lesions had been confused with mycotic and/or bacterial infections for 10-14 days. No inguinal lymphadenopathies were present and there was no fever. None of the patients had a previous history of recurrent labial or genital HSV infections or HIV infection. Histology was suggestive of HSV infection in two of five patients. Immunohistochemistry identified HSV type I (three patients) and HSV type II (two patients) infections. Viral culture with immunofluorescence viral identification revealed HSV type I in one of the four patients in whom a swab for viral culture was taken. Serology revealed past HSV infection. All lesions cured gradually after 10-14 days of intravenous acyclovir (aciclovir) treatment. CONCLUSION: Herpetic lesions of the perineal region represent a rare complication in bedridden geriatric patients in the absence of a previous history of HSV infections at the same site. Common traits of patients with this condition were the presence of numerous ulcerated lesions, prolonged time course, and confinement to bed. The latter probably modifies the skin condition, which triggers viral reactivation and favors cutaneous extension of the infection. Complementary diagnostic methods for viral detection and identification are mandatory. [less ▲]

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See detailFièvre Catarrhale Ovine chez les ruminants. Description clinique des cas vécus dans le Nord de l’Europe durant l’été-automne 2006
Guyot, Hugues ULg; Mauroy, Axel ULg; Thiry, Etienne ULg et al

in Bulletin des GTV (2007)

La fièvre catarrhale ovine (FCO) a été identifiée au Nord de l’Europe le 14 août 2006. L’Allemagne, la Belgique, les Pays-Bas et, dans une moindre mesure, le Grand-Duché de Luxembourg et la France ont été ... [more ▼]

La fièvre catarrhale ovine (FCO) a été identifiée au Nord de l’Europe le 14 août 2006. L’Allemagne, la Belgique, les Pays-Bas et, dans une moindre mesure, le Grand-Duché de Luxembourg et la France ont été affectés. Le sérotype 8 du virus de la FCO (exotique) a rapidement été identifié ainsi qu’un vecteur, Culicoides dewulfi, une espèce indigène du Nord de l’Europe. La maladie s’est rapidement développée et au 1er février 2007, on recensait 2137 foyers de FCO, toutes espèces de ruminants confondues. Globalement, la maladie a affecté davantage les bovins (54 %) que les ovins (46 %). Les signes cliniques le plus fréquemment observés chez les bovins étaient des lésions sur le museau et la cavité buccale (ulcérations/croûtes), de la salivation et des boiteries chez des animaux adultes. La morbidité et la mortalité animales étaient respectivement de maximum 5 % et 1 %. Les principaux signes cliniques rencontrés chez le mouton étaient également des lésions sur le museau et la cavité buccale (ulcérations/croûtes), de l’amaigrissement et des boiteries. La morbidité et la mortalité animales étaient respectivement de maximum 12 % et 6 %. Les signes cliniques n’étant pas pathognomoniques et le diagnostic différentiel relativement vaste, seul un examen de laboratoire permet de poser un diagnostic de certitude. [less ▲]

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See detailIntegrated approach for assessing climate change impacts on a regional chalky aquifer in Belgium
Goderniaux, Pascal ULg; Brouyère, Serge ULg; Dassargues, Alain ULg

in Changes in water resource systems: methodologies to maintain water security and ensure integrated management (2007)

An integrated hydrological model was developed in order to study the potential effects of climate change on groundwater resources. This model considers most hydrological processes in a physically ... [more ▼]

An integrated hydrological model was developed in order to study the potential effects of climate change on groundwater resources. This model considers most hydrological processes in a physically consistent way. More particularly, groundwater flows are modelled using a spatially distributed finite element approach. The river-aquifer interactions are explicitly taken into account in the model, as well as the spatial heterogeneity of the chalk geology characteristics. After a detailed calibration on the last 30 years and validation on recent periods, quantitative interpretations can be drawn from the ground¬water model results. Considering IPCC climate change scenarios, it appears that, on a multi-annual basis, most tested scenarios predict a decreasing trend in groundwater levels in the Geer Basin. These first results indicate that groundwater deficits may be expected in the future in Belgium. Moreover, at this stage of the study, this trend is computed for a very “optimistic” scenario, neglecting all other pressure changes on the groundwater resources (i.e. no change in land use and in pumping conditions). [less ▲]

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See detailCarte hydrogéologique de Wallonie 1/25000. 65/7-8, Limerlé-Langler.
Bouezmarni, Mohamed ULg; Denne, Pierre; Debbaut, Vincent ULg

Cartographic material (2007)

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See detailL’emploi de celeriter chez César : un cas d’étude du contexte des mots fréquents dans une œuvre
Denooz, Joseph ULg

in Denooz, Joseph; Dortu, Véronique; Steinmetz, Rudy (Eds.) Mosaïque, Mélanges offerts à Pierre Somville (2007)

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See detailOver (p)reparatiewetten
Leleu, Yves-Henri ULg

in Tijdschrift voor Privaatrecht (2007), liv. 2

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See detailA therapeutic strategy for treatment of the bovine respiratory disease complex: The rationale for the combination of a nonsteroidal anti-inflammatory drug with an antibiotic
Lekeux, Pierre ULg

in Cattle Practice (2007), 15(Part 2), 115-119

The bovine respiratory disease complex (BRDC) can be caused by a number of factors involving the animal, its environment, and the presence of infectious agents. The syndrome can be classified into four ... [more ▼]

The bovine respiratory disease complex (BRDC) can be caused by a number of factors involving the animal, its environment, and the presence of infectious agents. The syndrome can be classified into four grades: Grade 1, subclinical disease; Grade 2, compensated clinical disease; Grade 3, noncompensated clinical disease; and Grade 4, irreversible clinical disease, which threatens the animal's survival. The predisposition of cattle, especially beef calves, to respiratory problems is related to their lack of functional pulmonary hardiness. Selection of breeds that demonstrate adequate pulmonary function and sufficient ventilatory reserve may help in the control of BRDC, but this approach is difficult to implement and slow to produce results. Prophylactic measures, including vaccination programmes and modifying management practices to reduce stress, also have a place in prevention of BRDC. A therapeutic strategy to minimise the economic impact of BRDC includes the use of appropriate antibacterial therapy, modulation of the pulmonary inflammatory reaction, and correction of mechanical disorders. Most cattle affected by BRDC are classified as Grade 3. In these cases, irreversible damage to the lung can only be avoided by simultaneous control of bacterial infection and local inflammation. The basic therapeutic strategy described in this article involves the combination of an antibiotic, such as florfenicol, to act against the relevant pathogens and a nonsteroidal anti-inflammatory drug (NSAID), such as flunixin, to act against the deleterious effects of inflammation [less ▲]

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See detailL'atlas de Gérard Mercator
Adam, Renaud ULg; Bracke, Wouter

in Bracke, Wouter; Danckaert, Lisette; De Candt, Caroline (Eds.) et al ormatting Europe : mapping a continent : dix siècles de cartes d'Europe dans les collections de la Bibliothèque royale de Belgique (2007)

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See detailCaractérisation granulo-morphologique en 3D de poudres métalliques par micro-tomographie rayons-x
Gregoire, Max; Pirard, Eric ULg

in Dodds, J. A. (Ed.) Science & Technologie des Poudres - PMF 2007 (2007)

La morphologie des particules est une propriété essentielle pour comprendre et prédire leur rhéologie, leur agglomération, leur compaction et bien d'autres de leurs propriétés physiques. Suite à l ... [more ▼]

La morphologie des particules est une propriété essentielle pour comprendre et prédire leur rhéologie, leur agglomération, leur compaction et bien d'autres de leurs propriétés physiques. Suite à l'apparition de nouvelles techniques d'imagerie en trois dimensions adaptées aux matériaux, il est à présent possible d'étendre les descripteurs de forme existant en deux dimensions à la troisième. Deux échantillons de particules métalliques dont l'étendue granulaire est de 150-250 μm ont été selectionnés. Le choix de ces poudres est un véritable défi car la forme complexe des particules justifie l'élaboration de nouveaux descripteurs de taille et de forme. Cet article présentes les résultats de la caractérisation morphologique en trois dimensions de matériaux granulaires. L'acquisition d'images est pratiquée par microtomographie des rayons X permettant une résolution inférieure à 10 μm. Pour chaque particule, le volume, la surface, l'allongement, l'aplatissement, la convexité et le rayon de la sphère maximale inscrite sont calculés en trois dimensions. Les algorithmes écrits pour mesurer ces propriétés ont été validés sur des particules synthétiques. La réalisation d'une analyse morphologique complète de quelques milliers de particules permet d'appréhender les paramètres de forme de façon statistique. Finalement, les résultats seront confrontés à ceux obtenus par analyse d'image statique (SIA) en 2D. [less ▲]

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See detailA new tripodal ligand system based on the iminophosphorane functional group. Part 1: Synthesis and characterization
Beaufort, Laurence; Delaude, Lionel ULg; Noels, Alfred ULg

in Tetrahedron (2007), 63(30), 7003-7008

Two tripodal alcohols, viz., 1,1,1-tris(hydroxymethyl) ethane and alpha, alpha, alpha-tris(hydroxymethyl) toluene were converted by an efficient multi-step pathway involving azide formation into the ... [more ▼]

Two tripodal alcohols, viz., 1,1,1-tris(hydroxymethyl) ethane and alpha, alpha, alpha-tris(hydroxymethyl) toluene were converted by an efficient multi-step pathway involving azide formation into the corresponding tris(iminophosphorane) scaffolds bearing cyclopentyl (Cp) or phenyl groups on their phosphorus atoms, R-C(CH2-N] PR'(3))(3) (R Me or Ph, R'=Cp or Ph). The synthesis of some representative transition-metal complexes of Cu(I), Cu(II), Ni(II), and Pd(II) bearing these new tridentate ligands is also reported. (C) 2007 Elsevier Ltd. All rights reserved. [less ▲]

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See detailStructure modification in osteoarthritis
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in European Musculoskeletal Review (2007)

For decades, the traditional pharmacological management of osteoarthritis (OA) has been mainly symptomatic, despite a lack of evidence of its influence on the duration of the disease and its progression ... [more ▼]

For decades, the traditional pharmacological management of osteoarthritis (OA) has been mainly symptomatic, despite a lack of evidence of its influence on the duration of the disease and its progression. However, in recent years several sets of guidelines, recommendations or points to consider have been issued by regulatory authorities or scientific groups regarding requirements for the registration of drugs to be used in the treatment of OA. The ideal outcomes currently include pain and function assessment for symptom-modifying drugs, and joint-space narrowing (JSN) assessed by plain radiography for structure-modifying compounds. Taking advantage of these more precise recommendations, several chemical entities have been carefully investigated for the management of OA. This article provides a summary of the available evidence demonstrating that some compounds can effectively interfere with the structural progression of the disease. Avocado/Soybean Unsaponifiables The unsaponifiable part of avocado (A) and soybean (S) oils (ASU) mixed in a ratio of 1:2 (A1:S2) has been investigated in the treatment of connective tissues, including in OA, for several years. A pilot randomised, double-blind, placebo-controlled trial with follow-up over two years failed to demonstrate a structural effect of ASU in 163 patients with painful hip OA.1 However, in a post hoc analysis a significant difference was detected in the subgroup with a baseline joint-space width (JSW) smaller than 2.45mm: joint space loss was halved in the treated group (-0.43±0.51mm) compared with the placebo group (-0.86±0.62mm; p=0.01). This finding suggests that ASU may have a structure-modifying effect in patients with severe hip OA. Chondroitine Sulphate Chondroitine sulphate (CS) is a major component of the extra-cellular matrix from many connective tissues, including – but not limited to – cartilage, bone, skin, ligaments and tendons. In the articular cartilage, the high content of CS in the aggrecan plays a major role in creating considerable osmotic swelling pressure, which expands the matrix and places the collagen network under tension. In a pilot double-blind study, JSW measurement on digitalised radiographs of the extended knees was used to compare the effects of CS 800mg/day and a placebo in patients with knee OA.2 There were 23 patients in each group. After one year, JSW was unchanged in the treated group but had decreased by 0.4mm in the placebo group (p<0.005). No significant difference was found for JSW at the narrowest site. The small number of patients for whom end-point values were available (12 in the placebo group and 14 in the CS group) limits the relevance of the results. Another study randomised a total of 120 patients with symptomatic knee OA into two groups receiving either 800mg CS or placebo per day for two periods of three months during one year.3 Radiological progression was assessed as a secondary outcome by automatic measurement of medial femoro-tibial JSW on weight-bearing X-rays of both knees. Radiological progression at month 12 showed significantly decreased JSW in the placebo group, with no change in the CS group. [less ▲]

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See detailLa implantación de la librería alemana en España e Hispanoamérica
Ceballos Viro, Alvaro ULg

in Bauer, Elisabeth; Hertrampf, Marina; Kienberger, Antonia (Eds.) et al Handeln und Verhandeln, Beiträge zum 22. Nachwuchskolloquium der Romanistik (2007)

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See detailPolymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease.
Georges, Michel ULg; Coppieters, Wouter ULg; Charlier, Carole ULg

in Current opinion in genetics & development (2007), 17(3), 166-76

The expression of at least a third of mammalian genes is post-transcriptionally fine-tuned by approximately 1000 microRNAs (miRNAs), assisted by the RNA silencing machinery, comprising tens of components ... [more ▼]

The expression of at least a third of mammalian genes is post-transcriptionally fine-tuned by approximately 1000 microRNAs (miRNAs), assisted by the RNA silencing machinery, comprising tens of components. Polymorphisms and mutations in the corresponding sequence space (machinery, miRNA precursors and target sites) are likely to make a significant contribution to phenotypic variation, including disease susceptibility. Here we review basic miRNA biology in animals, survey the available evidence for DNA sequence polymorphisms affecting miRNA-mediated gene regulation and thus phenotype, and discuss their possible importance in the determination of complex traits. [less ▲]

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See detailStructural basis for the actin-binding function of missing-in-metastasis.
Lee, Sung Haeng; Kerff, Frédéric ULg; Chereau, David et al

in Structure (2007), 15(2), 145-55

The adaptor protein missing-in-metastasis (MIM) contains independent F- and G-actin binding domains, consisting, respectively, of an N-terminal 250 aa IRSp53/MIM homology domain (IMD) and a C-terminal ... [more ▼]

The adaptor protein missing-in-metastasis (MIM) contains independent F- and G-actin binding domains, consisting, respectively, of an N-terminal 250 aa IRSp53/MIM homology domain (IMD) and a C-terminal WASP-homology domain 2 (WH2). We determined the crystal structures of MIM's IMD and that of its WH2 bound to actin. The IMD forms a dimer, with each subunit folded as an antiparallel three-helix bundle. This fold is related to that of the BAR domain. Like the BAR domain, the IMD has been implicated in membrane binding. Yet, comparison of the structures reveals that the membrane binding surfaces of the two domains have opposite curvatures, which may determine the type of curvature of the interacting membrane. The WH2 of MIM is longer than the prototypical WH2, interacting with all four subdomains of actin. We characterize a similar WH2 at the C terminus of IRSp53 and propose that in these two proteins WH2 performs a scaffolding function. [less ▲]

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See detailIntroduction du catalogue de l'exposition Acquisitions des Collections artistiques de l’Université de Liège 1998-2006. Peintures, dessins…
Duchesne, Jean-Patrick ULg

in Catalogue de l'exposition Acquisitions des Collections artistiques de l’Université de Liège 1998-2006. Peintures, dessins… (2007)

Detailed reference viewed: 17 (2 ULg)