References of "2007"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailSkin in maturity: the endocrine and neuroendocrine pathways.
Quatresooz, Pascale ULiege; Pierard, Claudine ULiege; Kharfi, Monia et al

in International Journal of Cosmetic Science (2007), 29(1), 1-6

Irrespective of age, most of the skin components are under the physiological control of endocrine and neuroendocrine factors. There is evidence that skin ageing appears complex showing much ... [more ▼]

Irrespective of age, most of the skin components are under the physiological control of endocrine and neuroendocrine factors. There is evidence that skin ageing appears complex showing much interindividual variability. Conceptually, ageing is a single biological process that is influenced and modulated by a series of various internal and exogenous factors. Among them, hormones and neuroendocrine signals play key roles in several ways. Ageing of most endocrine glands will in turn alter the skin biology. In addition, the age-related reduction in the intrinsic neuroendocrine activity of the skin will also alter the ageing rate of this organ. At last, various endocrinopathies will boost or conversely decrease the severity of the signs of cutaneous ageing. [less ▲]

Detailed reference viewed: 48 (10 ULiège)
Full Text
Peer Reviewed
See detailDowngrading skin climacteric aging by hormone replacement therapy.
Quatresooz, Pascale ULiege; Pierard, Gérald ULiege

in Expert Review of Dermatology (2007), 2

Detailed reference viewed: 13 (2 ULiège)
Full Text
Peer Reviewed
See detailGlucocorticoids Modulate Tumor Radiation Response through a Decrease in Tumor Oxygen Consumption
Crokart, Nathalie; JORDAN, Bénédicte; BAUDELET, Christine et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (2007), 15(13), 6305

Purpose: We hypothesized that glucocorticoids may enhance tumor radiosensitivity by increasing tumor oxygenation (pO2) through inhibition of mitochondrial respiration. <br /> <br />Experimental Design ... [more ▼]

Purpose: We hypothesized that glucocorticoids may enhance tumor radiosensitivity by increasing tumor oxygenation (pO2) through inhibition of mitochondrial respiration. <br /> <br />Experimental Design: The effect of three glucocorticoids (hydrocortisone, dexamethasone, and prednisolone) on pO2 was studied in murine TLT liver tumors and FSaII fibrosarcomas. At the time of maximum pO2 (tmax, 30 min after administration), perfusion, oxygen consumption, and radiation sensitivity were studied. Local pO2 measurements were done using electron paramagnetic resonance. The oxygen consumption rate of tumor cells after in vivo glucocorticoid administration was measured using high-frequency electron paramagnetic resonance. Tumor perfusion and permeability measurements were assessed by dynamic contrast-enhanced magnetic resonance imaging. <br /> <br />Results: All glucocorticoids tested caused a rapid increase in pO2. At tmax, tumor perfusion decreased, indicating that the increase in pO2 was not caused by an increase in oxygen supply. Also at tmax, global oxygen consumption decreased. When irradiation (25 Gy) was applied at tmax, the tumor radiosensitivity was enhanced (regrowth delay increased by a factor of 1.7). <br /> <br />Conclusion: These results show the potential usefulness of the administration of glucocorticoids before irradiation. [less ▲]

Detailed reference viewed: 101 (10 ULiège)
Full Text
Peer Reviewed
See detailEffects of age and allergen-induced airway inflammation in cats: Radiographic and cytologic correlation
Kirschvink, Nathalie; Kersnak, Emilie; Leemans, Jérôme ULiege et al

in Veterinary Journal (2007), 174(3), 644-651

Thoracic radiography is an important diagnostic tool for feline respiratory medicine. The aim of this study was (1) to assess agerelated changes of thoracic radiographic views in healthy young cats and (2 ... [more ▼]

Thoracic radiography is an important diagnostic tool for feline respiratory medicine. The aim of this study was (1) to assess agerelated changes of thoracic radiographic views in healthy young cats and (2) to test if experimentally-induced bronchial inflammation by inhaling Ascaris suum (AS) allergens leads to radiographic changes after single or repeated exposures. Healthy cats (n = 15-30) aged between 6 and 30 months were evaluated. Eight healthy cats and eight AS-sensitised cats, respectively, inhaled sterile saline or allergen. Radiographs were taken 24 h before, and 6, 24 and 48 h after the challenge. Bronchoalveolar lavage (BAL) was performed after the last radiographic examination. AS-sensitised cats underwent three further allergen challenges at 3-month intervals. The radiographic evaluation was based on a scoring system considering bronchial, interstitial and alveolar patterns. A significant age-related increase in interstitial and total radiographic score was detected in healthy cats older than 18 months and in healthy cats older than 24 months. Whilst saline inhalation did not affect radiographic scores, a single AS challenge induced significant changes of all scores within 6-24 h. A significant positive correlation between radiographic scores and BAL neutrophils and eosinophils was found. Repeated AS challenges did not induce irreversible changes in radiographic scores. (c) 2006 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 25 (4 ULiège)
Full Text
See detailL'imiquimod: sus aux kératoses actiniques et à la cancérogenèse en champ.
Franchimont, Claudine ULiege; Nikkels, Arjen ULiege; Henry, Frédérique ULiege et al

in Dermatologie Actualité (2007), 102

Detailed reference viewed: 29 (4 ULiège)
See detailPsychanalyse et psychothérapie psychanalytique
Naziri, Despina ULiege

Conference (2007)

Detailed reference viewed: 30 (0 ULiège)
Full Text
Peer Reviewed
See detailA semiempirical approach to the intra-phycocyanin and inter-phycocyanin fluorescence resonance energy-transfer pathways in phycobilisomes.
Matamala, Adelio R; Almonacid, Daniel E; Figueroa, Maximiliano ULiege et al

in Journal of Computational Chemistry (2007), 28(7), 1200-7

A semiempirical methodology to model the intra-phycocyanin and inter-phycocyanin fluorescence resonance energy-transfer (FRET) pathways in the rods of the phycobilisomes (PBSs) from Fremyella diplosiphon ... [more ▼]

A semiempirical methodology to model the intra-phycocyanin and inter-phycocyanin fluorescence resonance energy-transfer (FRET) pathways in the rods of the phycobilisomes (PBSs) from Fremyella diplosiphon is presented. Using the Forster formulation of FRET and combining experimental data and PM3 calculation of the dipole moments of the aromatic portions of the chromophores, transfer constants between pairs of chromophores in the phycocyanin (PC) structure were obtained. Protein docking of two PC hexamers was used to predict the optimal distance and axial rotation angle for the staked PCs in the PBSs' rods. Using the distance obtained by the docking process, transfer constants between pairs of chromophores belonging to different PC hexamers were calculated as a function of the angle of rotation. We show that six preferential FRET pathways within the PC hexameric ring and 15 pathways between hexamers exist, with transfer constants consistent with experimental results. Protein docking predicted the quaternary structure for PCs in rods with inter-phycocyanin distance of 55.6 A and rotation angle of 20.5 degrees . The inter-phycocyanin FRET constant between chromophores at positions beta(155) is maximized at the rotation angle predicted by docking revealing the crucial role of this specific inter-phycocyanin channel in defining the complete set of FRET pathways in the system. [less ▲]

Detailed reference viewed: 14 (0 ULiège)
See detailMorphological development of the rat organ of Corti during the prenatal period
Thelen, Nicolas ULiege; Malgrange, B; Thiry, Marc ULiege

Poster (2007)

Detailed reference viewed: 3 (1 ULiège)
Full Text
Peer Reviewed
See detailEndometriosis: from research to clinical practice
Nisolle, Michelle ULiege; Alvarez Gonzalez, Maria-Luz ULiege; Colombo, M. et al

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2007), 162(5-6), 263-72

Endometriosis, defined by the development of endometrial tissue outside the uterus, is a benign disease responsible for infertility and pelvic pain. The diagnosis based on a detailed gynaecological ... [more ▼]

Endometriosis, defined by the development of endometrial tissue outside the uterus, is a benign disease responsible for infertility and pelvic pain. The diagnosis based on a detailed gynaecological history and a careful clinical examination should be done as early as possible in order to treat patients correctly. Medical treatment is not appropriate in all cases and surgical treatment should be proposed but morbidity is related to the severity of the lesion. Ectopic implantation of endometrial cells needs complex interactions between host tissue and epithelial endometrial cells. The conditions for the development of endometriosis are oestrogeno-dependent growth of endometrial cells, induction of angiogenesis and lymphangiogenesis. Principal cellular and molecular factors of angiogenesis, lymphangiogenesis and fibrosis should be identified in order to develop new therapeutic strategies of endometriosis. [less ▲]

Detailed reference viewed: 55 (10 ULiège)
Full Text
Peer Reviewed
See detailA fully coupled thermo-mechanical model for unsaturated soil
François, Bertrand ULiege; Laloui, Lyesse

in 2nd International Conference on Porous Media and its Applications in Science, Engineering and Industry (2007)

This paper addresses a new, unified thermomechanical constitutive model for unsaturated soils through a coupled study. In the context of elastoplasticity and the critical state theory, the model uses the ... [more ▼]

This paper addresses a new, unified thermomechanical constitutive model for unsaturated soils through a coupled study. In the context of elastoplasticity and the critical state theory, the model uses the concepts of multi-mechanism and bounding surface theory. This advanced constitutive approach involves thermo-plasticity of saturated and unsaturated soils. Bishop’s effective stress framework is adopted to represent the stress state in the soil. This stress is linked to the water retention curve, which is represented by an elasto-plastic model. Attention is focused particularly on the coupling relations inferred from this unified thermo-hydro-mechanical (THM) study. Finally, the theoretical aspects of the paper are supported by comparisons between numerical simulations and experimental results. [less ▲]

Detailed reference viewed: 52 (4 ULiège)
Full Text
Peer Reviewed
See detailNumerical modelling of the hydrogeological and geomechanical behaviour of a large slope movement: The Triesenberg landslide (Liechtenstein).
François, Bertrand ULiege; Tacher, Laurent; Bonnard, Christophe et al

in Canadian Geotechnical Journal (2007), 44(7), 840-857

Using advanced hydrogeological and geomechanical finite element modelling, it has been possible to model the mechanical behaviour of a large slope movement, the Triesenberg landslide. This slope is ... [more ▼]

Using advanced hydrogeological and geomechanical finite element modelling, it has been possible to model the mechanical behaviour of a large slope movement, the Triesenberg landslide. This slope is located along the Rhine valley in the Principality of Liechtenstein and covers an area of around 5 km(2), which includes two villages. Pore-water pressure fields calculated by the hydrogeological model were used as input for the geomechanical model. The results obtained through numerical simulation agree fairly well with field measurements of peak velocity, spatial and temporal distribution of velocity, and total displacements. Such results were obtained using a modified Cam-Clay elastoplastic constitutive model for which the required material parameters were obtained through careful geotechnical tests. These finite element models were carried out in two and three dimensions to gradually improve the understanding of the physical phenomena governing the hydrogeological conditions and the movements of the slope. [less ▲]

Detailed reference viewed: 24 (1 ULiège)
Full Text
Peer Reviewed
See detailL'image du mois. Onychopathie mycopsoriasique.
Franchimont, Claudine ULiege; Arrese Estrada, Jorge ULiege; Quatresooz, Pascale ULiege et al

in Revue Médicale de Liège (2007), 62(9), 533

Detailed reference viewed: 44 (3 ULiège)
Full Text
Peer Reviewed
See detailSepsis is associated with an upregulation of functional beta3 adrenoceptors in the myocardium.
Moniotte, S.; Belge, C.; Sekkali, B. et al

in European Journal of Heart Failure : Journal of the Working Group on Heart Failure of the European Society of Cardiology (2007), 9(12), 1163-71

OBJECTIVE: To analyze the implication of the beta3-adrenoceptor (beta3-AR) pathway in human septic myocardium and a murine model of sepsis, a condition associated with myocardial depression. METHODS AND ... [more ▼]

OBJECTIVE: To analyze the implication of the beta3-adrenoceptor (beta3-AR) pathway in human septic myocardium and a murine model of sepsis, a condition associated with myocardial depression. METHODS AND RESULTS: beta3-AR and eNOS protein abundance were increased (332+/-66.4% and 218+/-39.3; P<0.05) in hearts from septic patients. The effect of BRL37344, a beta3-AR-preferential agonist, was analyzed by videomicroscopy on the contractility of neonatal mouse ventricular myocytes (NMVM) incubated with conditioned medium from LPS-stimulated cultured macrophages (Mc-LPS+ medium). Stimulation of untreated NMVM with BRL37344 dose-dependently decreased the amplitude of contractile shortening (P<0.05). This response was abolished by L-NAME (NOS inhibitor). Incubation in Mc-LPS+ medium potentiated the depressing effect of BRL37344 (P<0.05) as well as of SR58611A (P<0.05) in wild-type myocytes. Importantly, the contractile depression was abrogated in cardiomyocytes from beta3-AR KO mice. CONCLUSIONS: beta3-AR are upregulated during sepsis in the human myocardium and by cytokines in murine cardiomyocytes, where they mediate an increased negative inotropic response to beta3 agonists. Activation of the beta3-AR pathway by catecholamines may contribute to the myocardial dysfunction in sepsis. [less ▲]

Detailed reference viewed: 10 (1 ULiège)
Full Text
Peer Reviewed
See detailContribution of cyclodextrins in the developement of different pharmaceutical formulations of a nex matrix metalloproteinase inhibitor
Evrard, Brigitte ULiege; Bertholet, Pascal; Guéders, Maud ULiege et al

in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry (2007), 57(1-4), 303-308

Ro 28-2653 is a new synthetic inhibitor of matrix metalloproteinases. The ability of these enzymes to degrade various components of the extracellular matrix seems to play a major role in tumors ... [more ▼]

Ro 28-2653 is a new synthetic inhibitor of matrix metalloproteinases. The ability of these enzymes to degrade various components of the extracellular matrix seems to play a major role in tumors progression and is potentially effective against bronchial remodeling in asthma and BPCO. Ro 28-2653 is very poorly soluble in water. This low solubility estimated at about 0.56 lg/ml in water at 25 C gives rise to difficulties in pharmaceutical formulation of oral, injectable or <br />nebulizable solutions. The purpose of our study is to prepare and to characterize inclusion complexes between Ro 28-2653 and cyclodextrins and to investigate the biopharmaceutical repercussion of the inclusion of the active substance.The complex formation was investigated by phase solubility studies. 1H-NMR spectroscopy and molecular modeling studies were carried out to elucidate the structure of the inclusion <br />complex between Ro 28-2653 and cyclodextrin. Oral, intravenous and nebulizable solutions of Ro 28-2653 were developed with cyclodextrin. The in vivo studies were performed on healthy sheep for the pharmacokinetic evaluation of the oral and intravenous formulations while the nebulization of the complex solution was studied by using an asthma model in mouse. [less ▲]

Detailed reference viewed: 91 (22 ULiège)
Full Text
Peer Reviewed
See detailOxygen consumption of equine articular chondrocytes: Influence of applied oxygen tension and glucose concentration during culture.
Schneider, Nicole ULiege; Mouithys-Mickalad, Ange ULiege; Lejeune, Jean-Philippe ULiege et al

in Cell Biology International (2007), 31

We investigated the oxygen (O2) uptake of equine articular chondrocytes to assess their reactions to anoxia/re-oxygenation. They were cultured under 5% or 21% gas phase O2 and at glucose concentrations of ... [more ▼]

We investigated the oxygen (O2) uptake of equine articular chondrocytes to assess their reactions to anoxia/re-oxygenation. They were cultured under 5% or 21% gas phase O2 and at glucose concentrations of 0, 1.0 or 4.5 g/L in the culture medium (n = 3). Afterwards, the O2 consumption rate of the chondrocytes was monitored (oxymetry) before and after an anoxia period of 25 min. The glucose consumption and lactate release were measured at the end of the re-oxygenation period. The chondrocytes showed a minimal O2 consumption rate, which was hardly changed by anoxia. Independently from the O2 tension, glucose uptake by the cells was about 30% of the available culture medium glucose, thus higher for cells at 4.5 g/L glucose (n = 3). Lactate release was also independent from O2 tension, but lower for cells at 4.5 g/L glucose (n = 3). Our observations indicated that O2 consumption by equine chondrocytes was very low despite a functional mitochondrial respiratory chain, and nearly insensitive to anoxia/re-oxygenation. But the chondrocytes metabolism was modified by an excess of O2 and glucose. [less ▲]

Detailed reference viewed: 100 (19 ULiège)
Full Text
See detailPratiques de la lecture, de l'écriture et du calcul dans le milieu professionnel et à domicile
Hindryckx, Geneviève ULiege; Baye, Ariane ULiege; Crepin, Françoise ULiege

in Journal de l'alpha (2007), 159(juillet-août), 88-95

Detailed reference viewed: 27 (6 ULiège)
Full Text
Peer Reviewed
See detailNon-invasive assessment of airway responsiveness in healthy and allergen-sensitised cats by use of barometric whole body plethysmography
Kirschvink, N.; Leemans, Jérôme ULiege; Delvaux, François et al

in Veterinary Journal (2007), 173(2), 343-352

This study aimed at determining whether airway responsiveness (AR) tests performed by use of barometric whole body plethysmography (BWBP) were repeatable in cats and to what extent AR was affected by the ... [more ▼]

This study aimed at determining whether airway responsiveness (AR) tests performed by use of barometric whole body plethysmography (BWBP) were repeatable in cats and to what extent AR was affected by the nebulization protocol used, the age of the animals, the inflammatory status of the airways and prior bronchodilator treatment. Repeatability of AR was tested on two occasions in 30 healthy cats. The concentration of carbachol inducing a 300% increase of the enhanced pause (Penh) - an estimator of airflow limitation - was calculated (C-Penh300) and did not differ significantly between the two tests (0.035 +/- 0.017% compared to 0.034 +/- 0.016%) and was significantly and positively correlated. The comparison between rapidly and slowly increasing carbachol concentrations was performed in ten healthy cats and showed a significantly lower C-Penh300 (%) when slowly increasing concentrations were used (0.037 +/- 0.013% compared to 0.039 +/- 10.015%, P < 0.05). A significant age-related increase of C-Penh300 was evidenced by performing AR tests in 15 healthy cats at 12, 18, 24 and 30 months (12 months: 0.026 +/- 0.008%, 18 months: 0.031 +/- 0.009%, 24 months: 0.038 +/- 0.01%, 30 months: 0.043 +/- 0.014%, P < 0.05). C-Penh300 significantly decreased in 12 Ascaris suum-sensitised cats after allergen exposure (0.026 +/- 0.016% compared to 0.033 +/- 0.016%, P < 0.05) and was negatively correlated with the granulocyte percentage of bronchoalveolar lavage fluid (r = -0.36, P < 0.01). Compared with a placebo inhalation, pretreatment with inhaled salbutamol significantly increased C-Penh300 in four healthy cats (0.093 +/- 0.021% compared to 0.036 +/- 0.004%, P < 0.05). This study provides evidence that AR determination by use of BWBP is promising as non-invasive indicator of lower airway inflammation or for monitoring response to bronchodilator treatment. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 25 (3 ULiège)