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See detailConfrontation anatomo-clinique. Le cancer cutané a-t-il été éradique?
Arrese Estrada, Jorge ULg; Pierard, Gérald ULg; Ruiz Ballon, M. et al

in Revue Médicale de Liège (2007), 62(9), 582-4

Distinguishing complete removal of a skin cancer and its partial destruction is frequently requested by the clinicians and their patients. The information is awaited from the laboratory, but it is not ... [more ▼]

Distinguishing complete removal of a skin cancer and its partial destruction is frequently requested by the clinicians and their patients. The information is awaited from the laboratory, but it is not always correctly interpreted by the information-seekers. The factors influencing this assessment include the combination of the nature of the antineoplastic therapy, the sampling modality of the area to be examined, and the quality of the dermatopathology procedure. In addition, the possibility of neoplastic regression linked to scarring or, conversely, the existence of a possible field cancerisation should be taken into consideration. [less ▲]

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See detailSequence-optimised E2 constructs from BVDV-1b and BVDV-2 for DNA immunisation in cattle
Couvreur, B.; Letellier, C.; Olivier, Fabrice ULg et al

in Veterinary Research (2007), 38(6, NOV-DEC), 819-834

We report DNA immunisation experiments in cattle using plasmid constructs that encoded glycoprotein E2 from bovine viral diarrhoea virus (BVDV)-1 (E2.1) and BVDV-2 (E2.2). The coding sequences were ... [more ▼]

We report DNA immunisation experiments in cattle using plasmid constructs that encoded glycoprotein E2 from bovine viral diarrhoea virus (BVDV)-1 (E2.1) and BVDV-2 (E2.2). The coding sequences were optimised for efficient expression in mammalian cells. A modified leader peptide sequence from protein gD of BoHV1 was inserted upstream of the E2 coding sequences for efficient membrane export of the proteins. Recombinant E2 were efficiently expressed in COS7 cells and they presented the native viral epitopes as judged by differential recognition by antisera from cattle infected with BVDV-1 or BVDV-2. Inoculation of pooled plasmid DNA in young cattle elicited antibodies capable of neutralising viral strains representing the major circulating BVDV genotypes. [less ▲]

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See detailHuman gene organization driven by the coordination of replication and transcription
Huvet, Maxime; Nicolay, Samuel ULg; Touchon, Marie et al

in Genome Research (2007), 17(9), 1278-1285

In this work, we investigated a large-scale organization of the human genes with respect to putative replication origins. We developed an appropriate multiscale method to analyze the nucleotide ... [more ▼]

In this work, we investigated a large-scale organization of the human genes with respect to putative replication origins. We developed an appropriate multiscale method to analyze the nucleotide compositional skew along the genome and found that in more than one-quarter of the genome, the skew profile presents characteristic patterns consisting of successions of N-shaped structures, designated here N-domains, bordered by putative replication origins. Our analysis of recent experimental timing data confirmed that, in a number of cases, domain borders coincide with replication initiation zones active in the early S phase, whereas the central regions replicate in the late S phase. Around the putative origins, genes are abundant and broadly expressed, and their transcription is co-oriented with replication fork progression. These features weaken progressively with the distance from putative replication origins. At the center of domains, genes are rare and expressed in few tissues. We propose that this specific organization could result from the constraints of accommodating the replication and transcription initiation processes at chromatin level, and reducing head-on collisions between the two machineries. Our findings provide a new model of gene organization in the human genome, which integrates transcription, replication, and chromatin structure as coordinated determinants of genome architecture. [less ▲]

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See detailEléments de bioinformatique v3.0
Peulen, Olivier ULg

Learning material (2007)

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See detailSalt, the kidneys and hypertension
Krzesinski, Jean-Marie ULg; Cohen, E. P.

in Acta Clinica Belgica (2007), 62(5, Sep-Oct), 348-357

The kidneys play a major role in the regulation of the salt balance and thereby regulate blood pressure. Salt sensitivity is acquired or genetically-induced and is noted in about 50% of patients with ... [more ▼]

The kidneys play a major role in the regulation of the salt balance and thereby regulate blood pressure. Salt sensitivity is acquired or genetically-induced and is noted in about 50% of patients with essential hypertension.This property leads to a high cardiovascular risk. In this situation, the benefit of salt restriction is significant, and this dietary change should be associated with a high potassium intake. In patients treated by antihypertensive drugs, salt restriction improves the blood pressure control, which can permit a reduction of the number of drugs required to achieve a normal blood pressure. The recommended maximal salt intake should not exceed 6 grams/day (NaCl). Because most dietary salt comes from processed foods, the help of the food industry is crucial for a long-term compliance with a reduced salt intake, which could yield an additional important benefit in the reduction of cardiovascular risk. [less ▲]

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See detailMultatuli in Frankrijk. Van anarchist tot altermondialist
Andringa, Kim ULg

in Over Multatuli (2007)

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See detailValidating the MODIS LAI product by scaling up LAI measurements at a VALERI Alpine Meadow site, China.
Ma, M; Veroustraete, F; Lu, L et al

in Survey Review (2007), 39

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See detailPriority areas of intraspecific diversity: Larzac, a global hotspot for facultative paedomorphosis in amphibians
Denoël, Mathieu ULg

in Animal Conservation (2007), 10(1), 110-116

Although the designation of biodiversity hotspots is a valuable tool to improve conservation efforts, this is a concept primarily based on species diversity. In consequence, another component of ... [more ▼]

Although the designation of biodiversity hotspots is a valuable tool to improve conservation efforts, this is a concept primarily based on species diversity. In consequence, another component of biodiversity, adaptive variation, is often ignored in conservation and to my knowledge no attempt has been made to identify hotspots of remarkable intraspecific patterns. My aim was to focus on the process of facultative paedomorphosis (i.e. the retention of larval traits such as gills in adult variants), a rare developmental pathway. One hundred and seventy-four ponds were inventoried in Larzac (France) to determine the distribution and abundance of paedomorphic palmate newts Triturus helveticus (Amphibia, Caudata) and to compare these results with the current distribution of paedomorphs in this and other species. During this study, paedomorphic newts were found in 46 ponds, 32 of which were described here for the first time. Seventy-nine per cent of known paedomorphic populations of this species were found there, whereas this area covers only 0.5% of the distribution area of the species. This represents the highest known density of facultatively paedomorphic populations, all species being considered. Because these populations face a high threat of disappearance, Larzac should be designated as an intraspecific biodiversity hotspot in order to protect adaptive intraspecific variation. Future conservation-oriented work should focus not only on species distributions but also on phenotypically diverse but spatially localized variation. [less ▲]

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See detailPsychoneuroendocrinologie et neurosciences
Scantamburlo, Gabrielle ULg

Learning material (2007)

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See detailEtude d'impact de la MTR en Région wallonne
Delille, Nicolas ULg

Report (2007)

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See detailDroit et activités de l'ingénieur: module de droit social
Clesse, Jacques ULg

Learning material (2007)

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See detailElectrical transport and magnetic properties of Mn3O4-La0.7Ca0.3MnO3 ceramic composites prepared by a one-step spray-drying technique
Vertruyen, Bénédicte ULg; Fagnard, Jean-François ULg; Vanderbemden, Philippe ULg et al

in Journal of the European Ceramic Society (2007), 27(13-15), 3923-3926

La0.7Ca0.3MnO3/Mn3O4 composites can be synthesized in one step by thermal treatment of a spray-dried precursor, instead of mixing pre-synthesized powders. Another advantage of this composite system is ... [more ▼]

La0.7Ca0.3MnO3/Mn3O4 composites can be synthesized in one step by thermal treatment of a spray-dried precursor, instead of mixing pre-synthesized powders. Another advantage of this composite system is that a long sintering step can be used without leading to significant modification of the manganite composition. The percolation threshold is reached at ~ 20 vol% of manganite phase. The 77 K low field magnetoresistance is enhanced to ~ 11 % at 0.15 T when the composition is close to the percolation threshold. (c) 2007 Elsevier Ltd. All rights reserved. [less ▲]

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See detailCompléments et exercices d'application du droit social
Clesse, Jacques ULg

Learning material (2007)

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See detailLe plan de la Domus aux Bucranes et son système décoratif : pavements - parois peintes - stucs - plafonds.
Morard, Thomas ULg

in Perrier, Bertrand (Ed.) Villas, maisons, sanctuaires et tombeaux tardo-républicains. Découvertes et relectures récentes. Colloque internationale en l'honneur d'A. Gallina Zevi. (2007)

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See detailFiltering inertia-gravity waves from the initial conditions of the linear shallow water equations
Barth, Alexander ULg; Beckers, Jean-Marie ULg; Alvera Azcarate, Aïda ULg et al

in Ocean Modelling (2007), 19(3-4), 204-218

A method for filtering inertia-gravity waves from elevation and depth-averaged velocity is described. This filtering scheme is derived from the linear shallow water equations for constant depth and ... [more ▼]

A method for filtering inertia-gravity waves from elevation and depth-averaged velocity is described. This filtering scheme is derived from the linear shallow water equations for constant depth and constant Coriolis frequency. The filtered solution is obtained by retaining only the eigenvectors corresponding to the geostrophic equilibrium and by discarding explicitly the eigenvectors corresponding to the fast moving inertia-gravity waves. An alternative formulation is derived using a variational approach. Both filtering methods are tested numerically for a periodic domain with constant depth and the variational approach is implemented for a closed domain with large topographic variations. The filtering methods significantly reduce the amplitudes of the inertia-gravity waves while preserving the mean flow. The variational method is compared to the Incremental Analysis Update technique and the benefits of the variational filter are presented. (C) 2007 Elsevier Ltd. All rights reserved. [less ▲]

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See detailA Nested Model of the Cariaco Basin: Study of the Hydrography and Interactions with the Open Ocean
Alvera Azcarate, Aïda ULg; Barth, Alexander ULg; Virmani, J. I. et al

Conference (2007)

The circulation of the Cariaco Basin (Venezuela) is modeled using the Regional Ocean Model System (ROMS) nested in the global 1/12 degree Hybrid Coordinate Ocean Model (HYCOM). The objective of this work ... [more ▼]

The circulation of the Cariaco Basin (Venezuela) is modeled using the Regional Ocean Model System (ROMS) nested in the global 1/12 degree Hybrid Coordinate Ocean Model (HYCOM). The objective of this work is to obtain a better understanding of the Cariaco Basin circulation by studying the processes that link the basin with the Caribbean Sea. To our knowledge, this is the first attempt to model the circulation in the Cariaco Basin with a nested high resolution hydrodynamical model. In particular, we examined the interaction of the Cariaco Basin with the large-scale, open-ocean processes, as the westward Caribbean Current and the eastward subsurface counter-current flowing along the South America Caribbean coast. These two current systems connect the Cariaco Basin with the Caribbean Sea waters, and therefore are directly related to the ventilation of the basin. By studying the kinematics and dynamics of the Cariaco Basin we anticipate gaining a better understanding on how the past conditions affected the basin characteristics and hence the geological records obtained from the basin sediments. We will report on several years of observations from the continuous monitoring of currents within the basin, plus analyses of year-long model runs that provide a basin-wide, three-dimensional context for the circulation. [less ▲]

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