Rapport de la convention de recherche FR00001481 pour TOTAL

Report (2007)

A nested hydrodynamic model of the Cariaco Basin (Venezuela): study of the basin interactions with the Caribbean Sea

Conference (2007)

Contribution of cyclodextrins in the developement of different pharmaceutical formulations of a nex matrix metalloproteinase inhibitor

in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry (2007)

Ro 28-2653 is a new synthetic inhibitor of matrix metalloproteinases. The ability of these enzymes to degrade various components of the extracellular matrix seems to play a major role in tumors ... [more ▼]

Ro 28-2653 is a new synthetic inhibitor of matrix metalloproteinases. The ability of these enzymes to degrade various components of the extracellular matrix seems to play a major role in tumors progression and is potentially effective against bronchial remodeling in asthma and BPCO. Ro 28-2653 is very poorly soluble in water. This low solubility estimated at about 0.56 lg/ml in water at 25 C gives rise to difficulties in pharmaceutical formulation of oral, injectable or nebulizable solutions. The purpose of our study is to prepare and to characterize inclusion complexes between Ro 28-2653 and cyclodextrins and to investigate the biopharmaceutical repercussion of the inclusion of the active substance.The complex formation was investigated by phase solubility studies. 1H-NMR spectroscopy and molecular modeling studies were carried out to elucidate the structure of the inclusion complex between Ro 28-2653 and cyclodextrin. Oral, intravenous and nebulizable solutions of Ro 28-2653 were developed with cyclodextrin. The in vivo studies were performed on healthy sheep for the pharmacokinetic evaluation of the oral and intravenous formulations while the nebulization of the complex solution was studied by using an asthma model in mouse. [less ▲]

A perturbation finite element method for modeling moving conductive and magnetic regions without remeshing

in COMPEL (2007), 26(3), 700-711

Purpose - To develop a sub-domain perturbation technique for efficiently modeling moving systems in magnetodynamics with a magnetic field h-conform finite element (FE) formulation. Design/methodology ... [more ▼]

Purpose - To develop a sub-domain perturbation technique for efficiently modeling moving systems in magnetodynamics with a magnetic field h-conform finite element (FE) formulation. Design/methodology/approach - A reference problem is first solved in a global mesh excluding some moving regions and thus avoiding the inclusion of their meshes. Its solution gives the sources for a sequence of perturbation problems with the supplementary moving magnetic and conductive regions. Each of these sub-problems requires an appropriate proper volume mesh of the associated moving region and its surrounding region, with no need of interconnection. The solutions are transferred from one problem to the other through projections of source fields between meshes. Findings - The consideration of sub-problems and associated sources, in a sequence of perturbation problems, leads to a significant speed-up of the repetitive solutions in analyses of moving systems. A free movement in any direction can be considered with no need of remeshing. Originality/value - When working with the perturbation fields, the volume sources can be limited to the moving regions, what allows for homogeneous perturbation boundary conditions and reduces the computational efforts for projecting and evaluating the sources. The curl-conformity of the unknown magnetic field is preserved during the whole process thanks to the use of edge FEs for both the magnetic field and the intermediate source quantities. The sub-problem approach also gives an easy way to directly express the time derivatives in moving frames. [less ▲]

Chronic Toxicity Of Essential Oils Of 3 Local Aromatic Plants Towards Sitophilus Zeamais Motsch (Coleoptera : Curculionidae)

in African Journal of Agricultural Research (2007), 2(4), 164-167

NP-internal functions and extended uses of the 'type' nouns kind, sort, and type: Towards a comprehensive, corpus-based description

Book published by Rodopi (2007)

Mechanical constitutive framework for thermal effects on unsaturated soils.

in Proceeding of the 10th Int. Symp. on Numerical Models in Geomechanics, NUMOG X (2007)

Research interest in the thermo-mechanical behaviour of unsaturated soils is growing as a result of an increasing number of geomechanical problems involving both thermal and suction effects. The ... [more ▼]

Research interest in the thermo-mechanical behaviour of unsaturated soils is growing as a result of an increasing number of geomechanical problems involving both thermal and suction effects. The underground waste disposal is one such critical problem. Until now, these two environmental loadings have often been considered independently. This paper proposes a new unified thermo-mechanical framework for unsaturated soils based on thermo-hydro-mechanical (THM) experimental evidence on cohesive soils. The Bishop effective stress framework is adopted to represent the stress state in the soil in a unified fashion. This constitutive context based on the evolution of two key parameters (the preconsolidation pressure and the suction air-entry value) makes it possible to represent the main features of the thermo-mechanical behaviour of unsaturated soils. [less ▲]

Body condition and SCFOS supplement influence adipose tissue MRNA abundance

in Proceedings of the 2007 Nestlé Purina Nutrition Forum (2007)

L'article 710bis du Code civil et la suppression partielle des servitudes du fait de l'homme

in Revue de la Faculté de Droit de l'Université de Liège (2007), (2), 282-293

Le cheval en Mésopotamie, des origines à l’époque néo-assyrienne

in Cattelain, Pierre; Bozet, Nathalie (Eds.) Sur la piste du cheval. De la préhistoire à l’antiquité (2007)