References of "2007"
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See detailTreatment of small bowel subocclusive Crohn's disease with infliximab: an open pilot study
Louis, Edouard ULiege; Boverie, Jacques ULiege; Dewit, Olivier et al

in Acta Gastro-Enterologica Belgica (2007), 70(1, Jan-Mar), 15-19

Stricturing subocclusive small bowel Crohn's disease (CD) is often an indication for surgery. We embarked on an open label pilot study to assess the safety and efficacy of infliximab in patients with ... [more ▼]

Stricturing subocclusive small bowel Crohn's disease (CD) is often an indication for surgery. We embarked on an open label pilot study to assess the safety and efficacy of infliximab in patients with stricturing subocclusive CD. Patients and methods : A cohort of patients with a documented and symptomatic small bowel stricture caused by CD was studied. Patients had to be refractory to corticosteroids and/or immunosuppressives, and not in need for immediate surgery. The patients were treated by a single infusion of infliximab 5 mg/kg and followed up at w1, w2, w4 and w8. Results : After the 6(th) patients, the study was prematurely discontinued because the predefined safety thresholds of more than 2 surgeries within the first 5 patients was reached. Only two patients completed the 8 weeks study, with a positive response to infliximab and improvement of inflammation confirmed by the CRP and CT scan. Two patients had to be operated early and the last two patients first did well but worsened after one month and were operated 35 and 42 days after infliximab, respectively. No surgical complications occurred in the 4 operated patients. In conclusion, a subset of patients with subocclusive small bowel stricturing CD may benefit from infliximab. [less ▲]

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See detailSedimentology and magnetic susceptibility of the Upper Eifelian - Lower Givetian (Middle Devonian) in southwestern Belgium: insights into carbonate platform initiation
Mabille, Cédric ULiege; Boulvain, Frédéric ULiege

in Alvaro, J. J.; Aretz, M.; Boulvain, Frédéric (Eds.) et al Palaeozoic Reefs and Bioaccumulations: Climatic and Evolutionary Controls (2007)

The major part of the Hanonet Formation is deposited on a mixed siliciclastic– carbonate detrital ramp, whereas the top is dominated by carbonate-rimmed shelf-related sedimentation. The transition ... [more ▼]

The major part of the Hanonet Formation is deposited on a mixed siliciclastic– carbonate detrital ramp, whereas the top is dominated by carbonate-rimmed shelf-related sedimentation. The transition corresponds roughly to the Eifelian–Givetian boundary. This work is based on two stratigraphic sections located in the southern part of the Dinant Synclinorium. Petrographic study leads to the definition of 11 microfacies, which demonstrate important sedimentological differences existing between the sections. A curve showing microfacies evolution is interpreted in terms of changing bathymetry. An environmental model depicts the lateral transition from a multiclinal carbonate ramp (to the east) to a forereef setting (to the west). Magnetic susceptibility was used to establish accurate stratigraphic correlations between the two sections. It also leads to an appreciation of the relative importance of eustatic sea-level change and local sedimentation rate. The combined interpretation of the microfacies curves and the magnetic susceptibility provides a new view of the sedimentary dynamics of the studied sections and, in a more general way, a better understanding of the processes responsible for magnetic susceptibility variations in carbonate rocks. [less ▲]

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See detailLong-term outcome in dogs with sinonasal aspergillosis treated with intranasal infusions of enilconazole
Schuller, S.; Clercx, Cécile ULiege

in Journal of the American Animal Hospital Association (2007)

Long-term outcomes (mean 38+/-17 months) were evaluated in 27 dogs with sinonasal aspergillosis after successful medical treatment using intranasal infusions of 1% or 2% enilconazole (1%, n=15; 2%, n=12 ... [more ▼]

Long-term outcomes (mean 38+/-17 months) were evaluated in 27 dogs with sinonasal aspergillosis after successful medical treatment using intranasal infusions of 1% or 2% enilconazole (1%, n=15; 2%, n=12). Long-term outcomes with both treatment protocols were good, with half of the dogs being asymptomatic throughout the follow-up period. The remaining dogs showed mild clinical signs compatible with chronic rhinitis/sinusitis. These clinical signs were interpreted as chronic lymphoplasmacytic rhinitis/sinusitis and episodes of bacterial rather than fungal infection. Three dogs had confirmed reinfection or relapse 2 to 36 months after clinical resolution [less ▲]

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See detailSpatial dynamics of rRNAs within the cell nucleus
Thiry, Marc ULiege; Lamaye, Françoise; Thelen, Nicolas ULiege et al

Poster (2007)

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See detailImmunogenicity of infliximab: how to handle the problem?
Baert, Filip; De Vos, Martine; Louis, Edouard ULiege et al

in Acta Gastro-Enterologica Belgica (2007), 70(2), 163-70

BACKGROUND: The introduction of infliximab has greatly advanced the therapeutic armamentarium of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Although the benefit/risk ... [more ▼]

BACKGROUND: The introduction of infliximab has greatly advanced the therapeutic armamentarium of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Although the benefit/risk ratio for infliximab is positive, of particular concern has been the problem of immunogenicity ascribed to the chimeric properties of the drug. Antibody formation is associated with allergic reactions and loss of response. AIMS AND METHODS: A literature search was undertaken on the magnitude of the problem of immunogenicity and on the clinical consequences. A survey was conducted about the clinical practice and management of acute and delayed allergic reactions to infliximab in different centres in Belgium. For this, a questionnaire was sent to all members of the Belgian IBD research group (n = 38 belonging to 29 centers). RESULTS AND CONCLUSION: Infusion reactions are important immunologic events induced by the presence of a substantial concentration of antibodies against infliximab (ATI) in the serum. Concomitant immunosuppressive treatment may optimize response to infliximab by preventing the formation of antibodies. Steroid administration prior to an infliximab infusion can further reduce the immunogenicity. Probably the most effective strategy to optimize treatment and avoid immunogenicity is maintenance therapy. If infliximab therapy can be discontinued is yet unclear but when treatment goals have been reached, we feel this should be attempted. In the case of relapse, infliximab should be restarted as maintenance long term. Practical guidelines on how to handle the problem of immunogenicity to infliximab are important for clinicians treating patients with IBD. [less ▲]

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See detailL'écrivain et ses doubles. Les Deux Consciences de Camille Lemonnier
Denis, Benoît ULiege

in Textyles : Revue des Lettres Belges de Langue Française (2007), (31), 60-73

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See detailHistone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappa B activation by delaying IkappaBalpha mRNA resynthesis : comparison with tumor necrosis factor alpha
Horion, Julie ULiege; Gloire, Geoffrey ULiege; El Mjiyad, Nadia et al

in Journal of Biological Chemistry (2007), 282(21), 15383

NF-kappaB is a crucial transcription factor tightly regulated by protein interactions and post-translational modifications, like phosphorylation and acetylation. A previous study has shown that ... [more ▼]

NF-kappaB is a crucial transcription factor tightly regulated by protein interactions and post-translational modifications, like phosphorylation and acetylation. A previous study has shown that trichostatin A (TSA), a histone deacetylase inhibitor, potentiates tumor necrosis factor (TNF) alpha-elicited NF-kappaB activation and delays IkappaBalpha cytoplasmic reappearance. Here, we demonstrated that TSA also prolongs NF-kappaB activation when induced by the insulino-mimetic pervanadate (PV), a tyrosine phosphatase inhibitor that initiates an atypical NF-kappaB signaling. This extension is similarly correlated with delayed IkappaBalpha cytoplasmic reappearance. However, whereas TSA causes a prolonged IKK activity when addedtoTNFalpha, it does notwhenaddedtoPV.Instead, quantitative reverse transcriptase-PCR revealed a decrease of ikappabalphamRNAlevel after TSA addition to PV stimulation. This synthesis deficit of the inhibitor could explain the sustained NF-kappaB residence in the nucleus. In vivo analysis by chromatin immunoprecipitation assays uncovered that, forPVinduction but not forTNFalpha, the presence of TSA provokes several impairments on the ikappabalphapromoter: (i) diminution of RNA Pol II recruitment; (ii) reduced acetylation and phosphorylation of histone H3-Lys14 and -Ser10, respectively; (iii) decreased presence of phosphorylated p65-Ser536; and (iv) reduction of IKKalphabinding. The recruitment of these proteins on the icam-1 promoter, another NF-kappaB-regulated gene, is not equally affected, suggesting a promoter specificity of PV with TSA stimulation. Taken together, these data suggest that TSA acts differently depending on the NF-kappaB pathway and the targeted promoter in question. This indicates that one overall histone deacetylase role is to inhibit NF-kappaB activation by molecular mechanisms specific of the stimulus and the promoter. [less ▲]

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See detailCompression tests on a sandy silt at different suction and temperature levels.
François, Bertrand ULiege; Salager, Simon; El Youssouffi, M. Said et al

in ASCE Geotechnical Special Publication 157 (2007)

This paper presents a unified thermo-mechanical experimental study on a remoulded unsaturated sandy silt and brings a contribution to the understanding of the fundamental mechanics of unsaturated soils in ... [more ▼]

This paper presents a unified thermo-mechanical experimental study on a remoulded unsaturated sandy silt and brings a contribution to the understanding of the fundamental mechanics of unsaturated soils in non-isothermal conditions. The experimental program was carried out at four temperatures and four suction levels using two thermo-hydro-mechanical (THM) cells, one isotropic and the other oedometric. The effect of suction and temperature on the compressibility and on the apparent preconsolidation pressure of the soil is addressed. Finally, an analytical expression of the evolution of the apparent preconsolidation pressure with respect to temperature and suction is proposed. [less ▲]

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See detailRetirement age and health expenditures
Cremer, Helmuth; Lozachmeur, Jean-Marie; Pestieau, Pierre ULiege

in Annales d'Economie et de Statistique (2007), (83/84),

We study the design of pension benefits and contributions when an individual’s health status depends on his consumption of health services. Health services can be subsidized and their uniform public ... [more ▼]

We study the design of pension benefits and contributions when an individual’s health status depends on his consumption of health services. Health services can be subsidized and their uniform public provision is also considered. We show that the second-best policy induces early retirement and that health expenditures ought to be subsidized under plausible assumptions. When only linear subsidies are available, the case for uniform public provision of health services appears to be quite strong. [less ▲]

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See detailcompte rendu de Livre des miracles de saint Gilles
George, Philippe ULiege

in Revue d'Histoire Ecclésiastique (2007)

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See detailMedical Imaging in Engineering School
Verly, Jacques ULiege

Scientific conference (2007)

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See detailTagging and redistributive taxation
Boadway, Robin; Pestieau, Pierre ULiege

in Annales d'Economie et de Statistique (2007), (83/84),

We study optimal redistributive taxes when the population can be disaggregated into tagged groups. Under reasonable circumstances, the tax system will be more redistributive in the tagged group with the ... [more ▼]

We study optimal redistributive taxes when the population can be disaggregated into tagged groups. Under reasonable circumstances, the tax system will be more redistributive in the tagged group with the higher proportion of high-ability persons. We extend the analysis to the case where the tag reflects differences in resources required to achieve a given level of utility. The compensation given for needs depends on whether the income tax structure is differentiated by needs groups. [less ▲]

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See detailHIV-1 protease inhibitors do not interfere with provirus transcription and host cell apoptosis induced by combined treatment TNF-alpha plus TSA
Vandergeeten, Claire ULiege; Quivy, Vincent; Moutschen, Michel ULiege et al

in Biochemical Pharmacology (2007), 73(11), 1738-1748

HIV-1 latency represents a major hurdle to the complete eradication of the virus from patients under highly active anti-retroviral therapy (HAART) regimens. One solution to this problem would be to ... [more ▼]

HIV-1 latency represents a major hurdle to the complete eradication of the virus from patients under highly active anti-retroviral therapy (HAART) regimens. One solution to this problem would be to eliminate the latently infected cellular reservoirs by forcing gene expression in presence of HAART to prevent spreading of the infection by the newly synthesized viruses. Many studies have reported that a combination of a histone deacetylase inhibitor (HDACi) (i.e. TSA, NaBut, Valproic acid,...) with a pro-inflammatory cytokine (i.e. TNF alpha, IL-1,...) reactivates in a synergistic manner HIV-1 transcription in latently infected cells. The aim of the present study was to determine whether HIV-1 protease inhibitors (PIs) used in HAART (such as Saquinavir, Indinavir, Nelfinavir, Lopinavir, Ritonavir and Amprenavir) could interfere with the potential purge of the cellular reservoirs induced by a combined treatment involving TSA and TNF alpha. We showed, in two HIV-1 latently infected cell lines (ACH-2 and U1) that all PIs efficiently inhibited release of mature viral particles but did neither affect cell apoptosis nor NF-kappa B induction and HIV-1 transcription activation following combined treatment with TNF alpha + TSA. This study is encouraging in the fight against HIV-1 and shows that PIs should be compatible with an inductive adjuvent therapy for latent reservoir reduction/elimination in association with efficient HAART regimens. (c) 2007 Elsevier Inc. All rights reserved. [less ▲]

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See detailMicro and macro investigation on the hardening of a titanium alloy
Lelotte, Thomas; Rossi, Barbara ULiege; Habraken, Anne ULiege

in 11th World conference on titanium: Ti 2007, Kyoto 3-7 June 2007 (2007)

This paper presents the experimental and numerical tests made on the Titanium based alloy Ti6A14V to identify its yield locus and the hardening behaviour. A bi-axial experimental equipment has been used ... [more ▼]

This paper presents the experimental and numerical tests made on the Titanium based alloy Ti6A14V to identify its yield locus and the hardening behaviour. A bi-axial experimental equipment has been used to perform cyclic shear tests, simple shear tests and successive simple shear tests and plane-strain tests. Coupled with classical tensile tests, these tests enable to identify the yield locus and the hardening model. Teodosiu and Hu’s hardening law and isotropic Swift type hardening and kinematic Armstrong Frederick hardening models have been investigated. [less ▲]

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See detailThe structure at 2 A resolution of Phycocyanin from Gracilaria chilensis and the energy transfer network in a PC-PC complex.
Contreras-Martel, Carlos; Matamala, Adelio; Bruna, Carola et al

in Biophysical Chemistry (2007), 125(2-3), 388-96

Phycocyanin is a phycobiliprotein involved in light harvesting and conduction of light to the reaction centers in cyanobacteria and red algae. The structure of C-phycocyanin from Gracilaria chilensis was ... [more ▼]

Phycocyanin is a phycobiliprotein involved in light harvesting and conduction of light to the reaction centers in cyanobacteria and red algae. The structure of C-phycocyanin from Gracilaria chilensis was solved by X-ray crystallography at 2.0 A resolution in space group P2(1). An interaction model between two PC heterohexamers was built, followed by molecular dynamic refinement. The best model showed an inter-hexamer rotation of 23 degrees . The coordinates of a PC heterohexamer (alphabeta)(6) and of the PC-PC complex were used to perform energy transfer calculations between chromophores pairs using the fluorescence resonance energy transfer approach (FRET). Two main intra PC ((I)beta(3)(82)-->(I)alpha(1)(84)-->(I)alpha(5)(84)-->(I)beta(6)(82) and (I)beta(3)(153)-->(I)beta(5)(153)) and two main inter PC ((I)beta(6)(82)-->(II)beta(3)(82) and (I)beta(5)(153)-->(II)beta(3)(153)) pathways were proposed based on the values of the energy transfer constants calculated for all the chromophore pairs in the hexamer and in the complex. [less ▲]

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See detailSpectroscopic anatomy of a meteor with the very large telescope (ESO)
Jehin, Emmanuel ULiege; Jenniskens, P.; Cabanac, R. A. et al

in Advances in Space Research (2007), 39

A meteor spectrum was recorded serendipitously with the ESO Very Large Telescope during a long exposure in long-slit spectroscopic mode with the instrument FORS1. The -8 magnitude fireball crossed the ... [more ▼]

A meteor spectrum was recorded serendipitously with the ESO Very Large Telescope during a long exposure in long-slit spectroscopic mode with the instrument FORS1. The -8 magnitude fireball crossed the narrow (1 arcsec × 7 arcmin) slit during the observation of a high z supernova in normal service mode operation on May 12, 2002. The spectrum covers the range of 637 1050 nm, where the meteor’s air plasma emissions from N[SUB]2[/SUB], N and O dominate. The meteor trail appears moreover resolved along the slit but we conclude that this is because the meteor at 100 km altitude was out of focus for the VLT. The plasma excitation temperature varies only from about 4300 to 4365 K across the trail, based on the ratio of atomic and molecular nitrogen emissions. This is in agreement with the fact that the trail is not actually spatially resolved. Finally, carbon atom emission is not detected in the relatively unexplored range above 900 nm. [less ▲]

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See detailDetecting consciousness in minimally conscious patients
Vanhaudenhuyse, Audrey ULiege; Schnakers, Caroline ULiege; Boly, Mélanie ULiege et al

in Réanimation (2007), 16

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See detailL’apport de ‘l’enquête pragmatique’ à l’anthropologie du Maghreb. A propos d’une recherche comparative sur le sens de la justice en Tunisie et en France
Nachi, Mohamed ULiege

in BOUKRAA, BEN SALEM et KERROU, Ridha, Lilia et Mohamed (Ed.) Terrains et savoirs actuels de l’anthropologie (2007)

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