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See detailAnalysis of the support provided to student-athletes in Wallonia. The case of higher education
Cloes, Marc ULg; Lenzen, Benoit; Polis, Ariane

in Diniz, J. A.; Carreiro da Costa, F.; Onofre, M. (Eds.) Active lifestyles: The impact of education and sport. Proceedings of the AIESEP 2005 World Congress (2007)

In this paper, the first aspect to keep in mind deals with the student-athletes’status. Indeed, the European culture is rather different than the North America’s one. US students, for example, have many ... [more ▼]

In this paper, the first aspect to keep in mind deals with the student-athletes’status. Indeed, the European culture is rather different than the North America’s one. US students, for example, have many advantages to become top athletes. Those who are selected in school, college or university teams are well supported by their institution. The NCCA (National Collegiate Athletic Association) is trying to limit the participation of the freshmen to the university competitions in order to provide them a better teaching context. An overview of the situation of studentathletes in 12 European countries revealed that not all of them have developed a positive climate in favour of their student-athletes. [less ▲]

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See detailHIV-1 protease inhibitors do not interfere with provirus transcription and host cell apoptosis induced by combined treatment TNF-alpha plus TSA
Vandergeeten, Claire ULg; Quivy, Vincent; Moutschen, Michel ULg et al

in Biochemical Pharmacology (2007), 73(11), 1738-1748

HIV-1 latency represents a major hurdle to the complete eradication of the virus from patients under highly active anti-retroviral therapy (HAART) regimens. One solution to this problem would be to ... [more ▼]

HIV-1 latency represents a major hurdle to the complete eradication of the virus from patients under highly active anti-retroviral therapy (HAART) regimens. One solution to this problem would be to eliminate the latently infected cellular reservoirs by forcing gene expression in presence of HAART to prevent spreading of the infection by the newly synthesized viruses. Many studies have reported that a combination of a histone deacetylase inhibitor (HDACi) (i.e. TSA, NaBut, Valproic acid,...) with a pro-inflammatory cytokine (i.e. TNF alpha, IL-1,...) reactivates in a synergistic manner HIV-1 transcription in latently infected cells. The aim of the present study was to determine whether HIV-1 protease inhibitors (PIs) used in HAART (such as Saquinavir, Indinavir, Nelfinavir, Lopinavir, Ritonavir and Amprenavir) could interfere with the potential purge of the cellular reservoirs induced by a combined treatment involving TSA and TNF alpha. We showed, in two HIV-1 latently infected cell lines (ACH-2 and U1) that all PIs efficiently inhibited release of mature viral particles but did neither affect cell apoptosis nor NF-kappa B induction and HIV-1 transcription activation following combined treatment with TNF alpha + TSA. This study is encouraging in the fight against HIV-1 and shows that PIs should be compatible with an inductive adjuvent therapy for latent reservoir reduction/elimination in association with efficient HAART regimens. (c) 2007 Elsevier Inc. All rights reserved. [less ▲]

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See detailLa hausse du lait : que faut-il en penser ?
Burny, Philippe ULg; Froidmont, E.; Turlot, Amélie

Article for general public (2007)

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See detailBacterial protein synthesis in the pig's large intestine varies according to the fermented non-starch polysaccharides.
Bindelle, Jérôme ULg; Leterme, Pascal; Destain, Jean-Pierre ULg et al

in Journal of Animal Science (2007), 85(Suppl. 2), 114-115

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See detailLe projet de valorisation scientifique du Ranch de gibier de Nazinga
Portier, B.; Vermeulen, Cédric ULg; Delvingt, W.

in Delvingt, W.; Vermeulen, Cédric (Eds.) Nazinga (2007)

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See detailEmsian-Givetian stromatactis-coral hydrothermal mud mounds, Tafilalt-Maider, Morocco
Boulvain, Frédéric ULg

in Vennin, E.; Aretz, M.; Boulvain, Frédéric (Eds.) et al Facies from Palaeozoic reefs and bioaccumulations (2007)

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See detailFundamental and practical approaches to increase biocontrol efficacy
Jijakli, Haissam ULg; Ongena, M.; Höfte, M. et al

Book - IOBC/WPRS publisher (2007)

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See detailFabric transitions from shell accumulations to reefs: an introduction with Palaeozoic examples
Alvaro, J. J.; Aretz, M.; Boulvain, Frédéric ULg et al

in Alvaro, J. J.; Aretz, M.; Boulvain, Frédéric (Eds.) et al Palaeozoic Reefs and Bioaccumulations: Climatic and Evolutionary Controls (2007)

One unresolved conceptual problem in some Palaeozoic sedimentary strata is the boundary between the concepts of ‘shell concentration’ and ‘reef’. In fact, numerous bioclastic strata are transitional ... [more ▼]

One unresolved conceptual problem in some Palaeozoic sedimentary strata is the boundary between the concepts of ‘shell concentration’ and ‘reef’. In fact, numerous bioclastic strata are transitional coquina–reef deposits, because either distinct frame-building skeletons are not commonly preserved in growth position, or skeletal remains are episodically encrusted by ‘stabilizer’ (reef-like) organisms, such as calcareous and problematic algae, encrusting microbes, bryozoans, foraminifers and sponges. The term ‘parabiostrome’, coined by Kershaw, can be used to describe some stratiform bioclastic deposits formed through the growth and destruction, by fair-weather wave and storm wave action, of meadows and carpets bearing frame-building (archaeocyaths, bryozoans, corals, stromatoporoids, etc.) and/or epibenthic, non-frame-building (e.g. pelmatozoan echinoderms, spiculate sponges and many brachiopods) organisms. This paper documents six Palaeozoic examples of stabilized coquinas leading to (pseudo)reef frameworks. Some of them formed by storm processes (generating reef soles, aborted reefs or being part of mounds) on ramps and shelves and were consolidated by either encrusting organisms or early diagenesic processes, whereas others, bioclastic-dominated shoals in barrier shelves, were episodically stabilized by encrusting organisms, indicating distinct episodes in which shoals ceased their lateral migration [less ▲]

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See detailEffect of Annealing Atmosphere on the Galvanizing Behaviour of a Dual-Phase Steel
Khondker, Rubayat; Mertens, Anne ULg; McDermid, Joe R.

in Materials Science & Engineering : A (2007), 463

The influence of annealing atmosphere oxidation potential on the surface condition of an industrial dual-phase steel alloyed with 2 wt% Mn and 0.3 wt% mo has been studied by galvanizing simulation, with ... [more ▼]

The influence of annealing atmosphere oxidation potential on the surface condition of an industrial dual-phase steel alloyed with 2 wt% Mn and 0.3 wt% mo has been studied by galvanizing simulation, with particular attention towards alloying element segregation, the occurrence of selective oxidation of the surfaces immediately prior to hot-dip galvanizing and their effect on reactive wetting and coating adherence. The surface chemistry and morphology prior to dipping have been analyzed in detail, along with their evolution during annealing, and the coating quality and chemistry were characterized and interpreted in relation to the surface condition prior to dipping. [less ▲]

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See detailSound production mechanism in the clownfish Amphiprion clarkii (Amphiprioninae, Pomacentridae)
Colleye, Orphal ULg; Herrel, Anthony; Mauguit, Quentin et al

Poster (2007)

Clownfishes live in social group within sea anemones. They are prolific “singers” that produce a wide variety of sounds, described as “pops” and “chirps”, involved in both reproductive and agonistic ... [more ▼]

Clownfishes live in social group within sea anemones. They are prolific “singers” that produce a wide variety of sounds, described as “pops” and “chirps”, involved in both reproductive and agonistic interactions. Although clownfish sounds were recorded since 1930, the mechanism of sound production has remained unresolved. The sounds used to describe the sonic mechanism were directed towards hetero- and conspecifics that approach their sea anemone host. Sound recordings were synchronized using a high speed video (500 fps) coupled or not with an X-ray system. These systems allowed to quantify the movements of external and internal bones during sound production. Sounds were typically accompanied by rapid (< 30 ms) head movements such as elevation of the skull, lowering of the hyoid bar and the anterior part of the branchial basket, retraction of the pectoral girdle, and finally closing of the mouth. Synchronization of sound pulses with X-ray images indicates that sound is produced when the hyoid apparatus is completely lowered and the mouth closed by a previously unknown mechanism. Dissections of freshly dead specimens reveal an unusual ligament responsible for the rapid mouth closing. This ligament joins the hyoid bar to the internal part of the mandible. Acting as a cord, it forces the mandible to turn around its articulation during the lowering of the anterior part of the branchial basket, forcing the mouth to close. Sounds result from the collision of the jaw teeth, transferring energy to the jaws that are presumably the sound radiator. [less ▲]

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See detailAntibody evasion by the N terminus of murid herpesvirus-4 glycoprotein B.
Gillet, Laurent ULg; Stevenson, Philip G

in EMBO Journal (2007), 26(24), 5131-42

Herpesviruses characteristically transmit infection from immune hosts. Although their success in escaping neutralization by pre-formed antibody is indisputable, the underlying molecular mechanisms remain ... [more ▼]

Herpesviruses characteristically transmit infection from immune hosts. Although their success in escaping neutralization by pre-formed antibody is indisputable, the underlying molecular mechanisms remain largely unknown. Glycoprotein B (gB) is the most conserved component of the herpesvirus entry machinery and its N terminus (gB-NT) is a common neutralization target. We used murid herpesvirus-4 to determine how gB-NT contributes to the virus-antibody interaction. Deleting gB-NT had no obvious impact on virus replication, but paradoxically increased virion neutralization by immune sera. This reflected greater antibody access to neutralization epitopes on gH/gL, with which gB was associated. gB-NT itself was variably protected against antibody by O-linked glycans; on virions from epithelial cells it was protected almost completely. gB-NT therefore provides a protective and largely protected cover for a vulnerable part of gH/gL. The conservation of predicted glycosylation sites in other mammalian herpesvirus gB-NTs suggests that this evasion mechanism is widespread. Interestingly, the gB-NT glycans that blocked antibody binding could be targeted for neutralization instead by a lectin, suggesting a means of therapeutic counterattack. [less ▲]

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See detailStem cell transplantation in ALL : a donor versus no donor comparison in the EORTC ALL-4 study
Labar, Boris; Suciu, S.; Muus, P. et al

in Leukemia Research (2007)

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See detailExperimental validation protocol for micro-CT as screening tool for bone tissue engineering scaffolds
Kerckhofs, Greet ULg; Schrooten, Jan; Van Cleynenbreugel, Tim et al

Conference (2007)

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See detailExperimental investigation on the seismic behaviour of north European masonry houses
Degée, Hervé ULg; Denoël, Vincent ULg; Candeias, P. et al

in Proceedings of SISMICA 07, Sismic Congress (2007)

This paper presents the results of shaking table tests performed on two full-scale masonry houses typical from North-European countries. The main objective of the experimental study is to assess the ... [more ▼]

This paper presents the results of shaking table tests performed on two full-scale masonry houses typical from North-European countries. The main objective of the experimental study is to assess the seismic behaviour of such houses for situations of low to moderate seismicity and to investigate the actual effect of some reinforcing details. [less ▲]

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See detailCamelpox virus encodes a schlafen-like protein that affects orthopoxvirus virulence.
Gubser, Caroline; Goodbody, Rory; Ecker, Andrea et al

in Journal of General Virology (The) (2007), 88(Pt 6), 1667-76

Camelpox virus (CMLV) gene 176R encodes a protein with sequence similarity to murine schlafen (m-slfn) proteins. In vivo, short and long members of the m-slfn family inhibited T-cell development, whereas ... [more ▼]

Camelpox virus (CMLV) gene 176R encodes a protein with sequence similarity to murine schlafen (m-slfn) proteins. In vivo, short and long members of the m-slfn family inhibited T-cell development, whereas in vitro, only short m-slfns caused arrest of fibroblast growth. CMLV 176 protein (v-slfn) is most closely related to short m-slfns; however, when expressed stably in mammalian cells, v-slfn did not inhibit cell growth. v-slfn is a predominantly cytoplasmic 57 kDa protein that is expressed throughout infection. Several other orthopoxviruses encode v-slfn proteins, but the v-slfn gene is fragmented in all sequenced variola virus and vaccinia virus (VACV) strains. Consistent with this, all 16 VACV strains tested do not express a v-slfn detected by polyclonal serum raised against the CMLV protein. In the absence of a small animal model to study CMLV pathogenesis, the contribution of CMLV v-slfn to orthopoxvirus virulence was studied via its expression in an attenuated strain of VACV. Recombinant viruses expressing wild-type v-slfn or v-slfn tagged at its C terminus with a haemagglutinin (HA) epitope were less virulent than control viruses. However, a virus expressing v-slfn tagged with the HA epitope at its N terminus had similar virulence to controls, implying that the N terminus has an important function. A greater recruitment of lymphocytes into infected lung tissue was observed in the presence of wild-type v-slfn but, interestingly, these cells were less activated. Thus, v-slfn is an orthopoxvirus virulence factor that affects the host immune response to infection. [less ▲]

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See detailLa Balsamine et les Hommes
Monty, Arnaud ULg; Cristofoli, Sara ULg

Learning material (2007)

Les invasions biologiques sont actuellement considérées comme l’une des atteintes majeures à la biodiversité. Néanmoins, elles sont encore souvent mal perçues du grand public. Ce court-métrage s’inscrit ... [more ▼]

Les invasions biologiques sont actuellement considérées comme l’une des atteintes majeures à la biodiversité. Néanmoins, elles sont encore souvent mal perçues du grand public. Ce court-métrage s’inscrit dans ce contexte et présente le cas de la Balsamine géante (Impatiens glandulifera ROYLE), espèce très esthétique, mais aussi particulièrement dommageable pour la flore des berges de cours d’eau, dans son aire d’invasion. La Balsamine fut introduite en Europe il y a plus d’un siècle, depuis les hauts-plateaux indiens et l’Himalaya, pour ses qualités décoratives. Après une phase de latence, elle a commencé à se répandre dans les milieux naturels, favorisée par les perturbations anthropiques et par un engouement des jardiniers pour l’espèce. Actuellement, elle est devenue problématique dans plusieurs vallées belges comme celle de l’Ourthe, l’Amblève ou la semois. Dans ce court-métrage, sous forme de fable, la Balsamine nous conte l’histoire de son invasion, tantôt aidée, tantôt enrayée par l’Homme. Le texte, entièrement original, est basé sur les connaissances les plus actuelles de l’espèce et des mécanismes sous-jacents à l’invasion. L’objectifs des réalisateurs est d’interpeller le spectateur sur la problématique tout en lui suggérant des actions préventives. [less ▲]

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See detailInositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells.
Maréchal, Y.; Pesesse, X.; Jia, Y. et al

in Proceedings of the National Academy of Sciences of the United States of America (2007), 104

The contribution of the B isoform of inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase (or Itpkb) and inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P(4)], its reaction product, to B cell function ... [more ▼]

The contribution of the B isoform of inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase (or Itpkb) and inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P(4)], its reaction product, to B cell function and development remains unknown. Here, we show that mice deficient in Itpkb have defects in B cell survival leading to specific and intrinsic developmental alterations in the B cell lineage and antigen unresponsiveness in vivo. The decreased B cell survival is associated with a decreased phosphorylation of Erk1/2 and increased Bim gene expression. B cell survival, development, and antigen responsiveness are normalized in parallel to reduced expression of Bim in Itpkb(-/-) Bim(+/-) mice. Analysis of the signaling pathway downstream of Itpkb revealed that Ins(1,3,4,5)P(4) regulates subcellular distribution of Rasa3, a Ras GTPase-activating protein acting as an Ins(1,3,4,5)P(4) receptor. Together, our results indicate that Itpkb and Ins(1,3,4,5)P(4) mediate a survival signal in B cells via a Rasa3-Erk signaling pathway controlling proapoptotic Bim gene expression [less ▲]

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See detailNotes de recherche n°2. Evaluation des besoins en matière de zones d’activités économiques. Annexes
Lambotte, Jean-Marc ULg; Bastin, A.; Guillaume, N. et al

Report (2007)

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