References of "2007"
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See detailReactions cutanees indesirables a la chimiotherapie et leurs traitements.
Pierard, Gérald ULg; Paquet, Philippe; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2007), 62(5-6), 457-62

Chemotherapy is an essential component in the multidisciplinary management of many cancers. Skin reactions to chemotherapeutics are rather frequent, and their morbidity may be significant. It is wise to ... [more ▼]

Chemotherapy is an essential component in the multidisciplinary management of many cancers. Skin reactions to chemotherapeutics are rather frequent, and their morbidity may be significant. It is wise to identify them with precision in order to chose the most adequate preventive and therapeutic measures. The dermatopathology assessment is helpful for the diagnostic. [less ▲]

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See detailSleep transforms the cerebral trace of declarative memories
Gais, Steffen; Albouy, Geneviève ULg; Boly, Mélanie ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2007), 104(47), 18778-18783

After encoding, memory traces are initially fragile and have to be reinforced to become permanent. The initial steps of this process occur at a cellular level within minutes or hours. Besides this rapid ... [more ▼]

After encoding, memory traces are initially fragile and have to be reinforced to become permanent. The initial steps of this process occur at a cellular level within minutes or hours. Besides this rapid synaptic consolidation, systems consolidation occurs within a time frame of days to years. For declarative memory, the latter is presumed to rely on an interaction between different brain regions, in particular the hippocampus and the medial prefrontal cortex (mPFC). Specifically, sleep has been proposed to provide a setting that supports such systems consolidation processes, leading to a transfer and perhaps transformation of memories. Using functional MRI, we show that postlearning sleep enhances hippocampal responses during recall of word pairs 48 h after learning, indicating intrahippocampal memory processing during sleep. At the same time, sleep induces a memory-related functional connectivity between the hippocampus and the mPFC. Six months after learning, memories activated the mPFC more strongly when they were encoded before sleep, showing that sleep leads to long-lasting changes in the representation of memories on a systems level. [less ▲]

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See detailContribution à l’étude de faisabilité de séchoirs solaires pour les produits agricoles
Bennamoun, Lyes ULg; Belhamri, Azeddine

in Revue des Energies Renouvelables (2007)

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See detailLa destruction de la couche d'ozone et ses implications en Région wallonne
Mahieu, Emmanuel ULg

Report (2007)

Stratospheric ozone is an important constituent of the Earth's atmosphere since it protects the biosphere from the most harmful ultraviolet radiations emitted by the sun. Some human activiites such as the ... [more ▼]

Stratospheric ozone is an important constituent of the Earth's atmosphere since it protects the biosphere from the most harmful ultraviolet radiations emitted by the sun. Some human activiites such as the use of man-mande chlorofluorocarbons have resulted in major destruction of ozone, in particular in the polar regions of the stratosphere. The Montreal Protocol has been successful in limiting the emissions of ozone depleting substances such as the complete ozone recovery is expected to take place in 2050 over northern mid-latitudes. [less ▲]

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See detailComment j'explore...la piste toxique revisitée des sclérodermies.
Quatresooz, Pascale ULg; Paquet, Philippe ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2007), 62(3), 170-4

The name scleroderma is given to a spectrum of diseases which differ clinically and bear different prognostic risks. The origins of the various forms of the disease are unclear. A toxic influence has been ... [more ▼]

The name scleroderma is given to a spectrum of diseases which differ clinically and bear different prognostic risks. The origins of the various forms of the disease are unclear. A toxic influence has been suggested, particularly for the progressive systemic scleroderma. However, the imputability of the suspected chemicals often remains unsettled. [less ▲]

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See detailModeling the influence of Greenland ice sheet melting on the Atlantic meridional overturning circulation during the next millennia
Driesschaert, E.; Fichefet, T.; Goosse, H. et al

in Geophysical Research Letters (2007), 34(10),

A three-dimensional Earth system model of intermediate complexity including a dynamic ice sheet component has been used to investigate the long-term evolution of the Greenland ice sheet and its effects on ... [more ▼]

A three-dimensional Earth system model of intermediate complexity including a dynamic ice sheet component has been used to investigate the long-term evolution of the Greenland ice sheet and its effects on the Atlantic meridional overturning circulation (AMOC) in response to a range of stabilized anthropogenic forcings. Our results suggest that the Greenland ice sheet volume should experience a significant decrease in the future. For a radiative forcing exceeding 7.5 W m(-2), the modeled ice sheet melts away within 3000 years. A number of feedbacks operate during this deglaciation, implying a strong nonlinear relationship between the radiative forcing and the melting rate. Only in the most extreme scenarios considered, the freshwater flux from Greenland into the surrounding oceans ( of ca. 0.1 Sv during a few centuries) induces a noticeable weakening of the AMOC in the model. [less ▲]

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See detailAz MR-képalkotással vezérelt prostata-brachytherapia metodikai tervezése
LAKOSI, Ferenc ULg; Antal, Gergely; Vandulek, Csaba et al

in Magyar Radiologia (2007), 81(5-6), 224-229

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See detailTreatment of small bowel subocclusive Crohn's disease with infliximab: an open pilot study
Louis, Edouard ULg; Boverie, Jacques ULg; Dewit, Olivier et al

in Acta Gastro-Enterologica Belgica (2007), 70(1, Jan-Mar), 15-19

Stricturing subocclusive small bowel Crohn's disease (CD) is often an indication for surgery. We embarked on an open label pilot study to assess the safety and efficacy of infliximab in patients with ... [more ▼]

Stricturing subocclusive small bowel Crohn's disease (CD) is often an indication for surgery. We embarked on an open label pilot study to assess the safety and efficacy of infliximab in patients with stricturing subocclusive CD. Patients and methods : A cohort of patients with a documented and symptomatic small bowel stricture caused by CD was studied. Patients had to be refractory to corticosteroids and/or immunosuppressives, and not in need for immediate surgery. The patients were treated by a single infusion of infliximab 5 mg/kg and followed up at w1, w2, w4 and w8. Results : After the 6(th) patients, the study was prematurely discontinued because the predefined safety thresholds of more than 2 surgeries within the first 5 patients was reached. Only two patients completed the 8 weeks study, with a positive response to infliximab and improvement of inflammation confirmed by the CRP and CT scan. Two patients had to be operated early and the last two patients first did well but worsened after one month and were operated 35 and 42 days after infliximab, respectively. No surgical complications occurred in the 4 operated patients. In conclusion, a subset of patients with subocclusive small bowel stricturing CD may benefit from infliximab. [less ▲]

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See detailSedimentology and magnetic susceptibility of the Upper Eifelian - Lower Givetian (Middle Devonian) in southwestern Belgium: insights into carbonate platform initiation
Mabille, Cédric ULg; Boulvain, Frédéric ULg

in Alvaro, J. J.; Aretz, M.; Boulvain, Frédéric (Eds.) et al Palaeozoic Reefs and Bioaccumulations: Climatic and Evolutionary Controls (2007)

The major part of the Hanonet Formation is deposited on a mixed siliciclastic– carbonate detrital ramp, whereas the top is dominated by carbonate-rimmed shelf-related sedimentation. The transition ... [more ▼]

The major part of the Hanonet Formation is deposited on a mixed siliciclastic– carbonate detrital ramp, whereas the top is dominated by carbonate-rimmed shelf-related sedimentation. The transition corresponds roughly to the Eifelian–Givetian boundary. This work is based on two stratigraphic sections located in the southern part of the Dinant Synclinorium. Petrographic study leads to the definition of 11 microfacies, which demonstrate important sedimentological differences existing between the sections. A curve showing microfacies evolution is interpreted in terms of changing bathymetry. An environmental model depicts the lateral transition from a multiclinal carbonate ramp (to the east) to a forereef setting (to the west). Magnetic susceptibility was used to establish accurate stratigraphic correlations between the two sections. It also leads to an appreciation of the relative importance of eustatic sea-level change and local sedimentation rate. The combined interpretation of the microfacies curves and the magnetic susceptibility provides a new view of the sedimentary dynamics of the studied sections and, in a more general way, a better understanding of the processes responsible for magnetic susceptibility variations in carbonate rocks. [less ▲]

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See detailLong-term outcome in dogs with sinonasal aspergillosis treated with intranasal infusions of enilconazole
Schuller, S.; Clercx, Cécile ULg

in Journal of the American Animal Hospital Association (2007)

Long-term outcomes (mean 38+/-17 months) were evaluated in 27 dogs with sinonasal aspergillosis after successful medical treatment using intranasal infusions of 1% or 2% enilconazole (1%, n=15; 2%, n=12 ... [more ▼]

Long-term outcomes (mean 38+/-17 months) were evaluated in 27 dogs with sinonasal aspergillosis after successful medical treatment using intranasal infusions of 1% or 2% enilconazole (1%, n=15; 2%, n=12). Long-term outcomes with both treatment protocols were good, with half of the dogs being asymptomatic throughout the follow-up period. The remaining dogs showed mild clinical signs compatible with chronic rhinitis/sinusitis. These clinical signs were interpreted as chronic lymphoplasmacytic rhinitis/sinusitis and episodes of bacterial rather than fungal infection. Three dogs had confirmed reinfection or relapse 2 to 36 months after clinical resolution [less ▲]

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See detailSpatial dynamics of rRNAs within the cell nucleus
Thiry, Marc ULg; Lamaye, Françoise; Thelen, Nicolas ULg et al

Poster (2007)

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See detailImmunogenicity of infliximab: how to handle the problem?
Baert, Filip; De Vos, Martine; Louis, Edouard ULg et al

in Acta Gastro-Enterologica Belgica (2007), 70(2), 163-70

BACKGROUND: The introduction of infliximab has greatly advanced the therapeutic armamentarium of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Although the benefit/risk ... [more ▼]

BACKGROUND: The introduction of infliximab has greatly advanced the therapeutic armamentarium of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Although the benefit/risk ratio for infliximab is positive, of particular concern has been the problem of immunogenicity ascribed to the chimeric properties of the drug. Antibody formation is associated with allergic reactions and loss of response. AIMS AND METHODS: A literature search was undertaken on the magnitude of the problem of immunogenicity and on the clinical consequences. A survey was conducted about the clinical practice and management of acute and delayed allergic reactions to infliximab in different centres in Belgium. For this, a questionnaire was sent to all members of the Belgian IBD research group (n = 38 belonging to 29 centers). RESULTS AND CONCLUSION: Infusion reactions are important immunologic events induced by the presence of a substantial concentration of antibodies against infliximab (ATI) in the serum. Concomitant immunosuppressive treatment may optimize response to infliximab by preventing the formation of antibodies. Steroid administration prior to an infliximab infusion can further reduce the immunogenicity. Probably the most effective strategy to optimize treatment and avoid immunogenicity is maintenance therapy. If infliximab therapy can be discontinued is yet unclear but when treatment goals have been reached, we feel this should be attempted. In the case of relapse, infliximab should be restarted as maintenance long term. Practical guidelines on how to handle the problem of immunogenicity to infliximab are important for clinicians treating patients with IBD. [less ▲]

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See detailL'écrivain et ses doubles. Les Deux Consciences de Camille Lemonnier
Denis, Benoît ULg

in Textyles : Revue des Lettres Belges de Langue Française (2007), (31), 60-73

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See detailHistone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappa B activation by delaying IkappaBalpha mRNA resynthesis : comparison with tumor necrosis factor alpha
Horion, Julie ULg; Gloire, Geoffrey ULg; El Mjiyad, Nadia et al

in Journal of Biological Chemistry (2007), 282(21), 15383

NF-kappaB is a crucial transcription factor tightly regulated by protein interactions and post-translational modifications, like phosphorylation and acetylation. A previous study has shown that ... [more ▼]

NF-kappaB is a crucial transcription factor tightly regulated by protein interactions and post-translational modifications, like phosphorylation and acetylation. A previous study has shown that trichostatin A (TSA), a histone deacetylase inhibitor, potentiates tumor necrosis factor (TNF) alpha-elicited NF-kappaB activation and delays IkappaBalpha cytoplasmic reappearance. Here, we demonstrated that TSA also prolongs NF-kappaB activation when induced by the insulino-mimetic pervanadate (PV), a tyrosine phosphatase inhibitor that initiates an atypical NF-kappaB signaling. This extension is similarly correlated with delayed IkappaBalpha cytoplasmic reappearance. However, whereas TSA causes a prolonged IKK activity when addedtoTNFalpha, it does notwhenaddedtoPV.Instead, quantitative reverse transcriptase-PCR revealed a decrease of ikappabalphamRNAlevel after TSA addition to PV stimulation. This synthesis deficit of the inhibitor could explain the sustained NF-kappaB residence in the nucleus. In vivo analysis by chromatin immunoprecipitation assays uncovered that, forPVinduction but not forTNFalpha, the presence of TSA provokes several impairments on the ikappabalphapromoter: (i) diminution of RNA Pol II recruitment; (ii) reduced acetylation and phosphorylation of histone H3-Lys14 and -Ser10, respectively; (iii) decreased presence of phosphorylated p65-Ser536; and (iv) reduction of IKKalphabinding. The recruitment of these proteins on the icam-1 promoter, another NF-kappaB-regulated gene, is not equally affected, suggesting a promoter specificity of PV with TSA stimulation. Taken together, these data suggest that TSA acts differently depending on the NF-kappaB pathway and the targeted promoter in question. This indicates that one overall histone deacetylase role is to inhibit NF-kappaB activation by molecular mechanisms specific of the stimulus and the promoter. [less ▲]

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See detailCompression tests on a sandy silt at different suction and temperature levels.
François, Bertrand ULg; Salager, Simon; El Youssouffi, M. Said et al

in ASCE Geotechnical Special Publication 157 (2007)

This paper presents a unified thermo-mechanical experimental study on a remoulded unsaturated sandy silt and brings a contribution to the understanding of the fundamental mechanics of unsaturated soils in ... [more ▼]

This paper presents a unified thermo-mechanical experimental study on a remoulded unsaturated sandy silt and brings a contribution to the understanding of the fundamental mechanics of unsaturated soils in non-isothermal conditions. The experimental program was carried out at four temperatures and four suction levels using two thermo-hydro-mechanical (THM) cells, one isotropic and the other oedometric. The effect of suction and temperature on the compressibility and on the apparent preconsolidation pressure of the soil is addressed. Finally, an analytical expression of the evolution of the apparent preconsolidation pressure with respect to temperature and suction is proposed. [less ▲]

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See detailRetirement age and health expenditures
Cremer, Helmuth; Lozachmeur, Jean-Marie; Pestieau, Pierre ULg

in Annales d'Economie et de Statistique (2007), (83/84),

We study the design of pension benefits and contributions when an individual’s health status depends on his consumption of health services. Health services can be subsidized and their uniform public ... [more ▼]

We study the design of pension benefits and contributions when an individual’s health status depends on his consumption of health services. Health services can be subsidized and their uniform public provision is also considered. We show that the second-best policy induces early retirement and that health expenditures ought to be subsidized under plausible assumptions. When only linear subsidies are available, the case for uniform public provision of health services appears to be quite strong. [less ▲]

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See detailcompte rendu de Livre des miracles de saint Gilles
George, Philippe ULg

in Revue d'Histoire Ecclésiastique (2007)

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See detailMedical Imaging in Engineering School
Verly, Jacques ULg

Scientific conference (2007)

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