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See detailLe traitement du diabète de type 2: entre insulinosensibilisateurs et insulinosécrétagogues
Scheen, A. J.; Radermecker, R. P.; Philips, J. C. et al

in Revue Médicale de Liège (2007), 62 Spec No

Type 2 diabetes is a complex disease characterized by a dual defect of insulin secretion and insulin sensitivity, which may vary from patient to patient, but also along the natural history of the disease ... [more ▼]

Type 2 diabetes is a complex disease characterized by a dual defect of insulin secretion and insulin sensitivity, which may vary from patient to patient, but also along the natural history of the disease in a particular patient. Besides the lifestyle changes, the treatment strategy comprises the administration of agents that promote insulin secretion and/or that improve insulin sensitivity. Drugs facilitating weight loss also improve glucose control by reducing insulin resistance. A global approach should be recommended to reduce the high cardiovascular risk of diabetic patients. The present article aims at summarizing our contribution to the development of drugs designed for the treatment of type 2 diabetes. [less ▲]

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See detailComorbidity and disease status based risk stratification of outcomes among patients with acute myeloid leukemia or myelodysplasia receiving allogeneic hematopoietic cell transplantation.
Sorror, Mohamed L; Sandmaier, Brenda M; Storer, Barry E et al

in Journal of Clinical Oncology (2007), 25(27), 4246-54

PURPOSE: Retrospective studies have shown similar survival among patients with acute myeloid leukemia (AML) and myelodysplasia (MDS) after nonmyeloablative compared with myeloablative conditioning ... [more ▼]

PURPOSE: Retrospective studies have shown similar survival among patients with acute myeloid leukemia (AML) and myelodysplasia (MDS) after nonmyeloablative compared with myeloablative conditioning. Refined risk stratification is required to design prospective trials. PATIENTS AND METHODS: We stratified outcomes among patients with AML (n = 391) or MDS (n = 186) who received either nonmyeloablative (n = 125) or myeloablative (n = 452) allogeneic hematopoietic cell transplantation (HCT) based on comorbidities, as assessed by a HCT-specific comorbidity index (HCT-CI), as well as disease status. Patients receiving nonmyeloablative conditioning were older, more frequently pretreated, more often received unrelated grafts, and more often had HCT-CI scores of 3 compared with patients who received myeloablative conditioning. RESULTS: Patients with HCT-CI scores of 0 to 2 and either low or high disease risks had probabilities of overall survival at 2 years of 70% and 57% after nonmyeloablative conditioning compared with 78% and 50% after myeloablative conditioning, respectively. Patients with HCT-CI scores of 3 and either low or high disease risks had probabilities of overall survival of 41% and 29% with nonmyeloablative conditioning compared with 45% and 24% with myeloablative regimens, respectively. After adjusting for pretransplantation differences, stratified outcomes were not significantly different among patients receiving nonmyeloablative compared with myeloablative conditioning, with the exception of lessened nonrelapse mortality (hazard ratio, 0.50; P = .05) in the highest risk group. CONCLUSION: Patients with low comorbidity scores could be candidates for prospective randomized trials comparing nonmyeloablative and myeloablative conditioning regardless of disease status. Additional data are required for patients with low-risk diseases and high comorbidity scores. Novel antitumor agents combined with nonmyeloablative HCT should be explored among patients with high comorbidity scores and advanced disease. [less ▲]

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See detailSieb 6 : Morphosyntaktische Elemente
Zeevaert, Ludger ULg

in Hufeisen, Britta; Marx, Nicole (Eds.) EuroComGerm - Die sieben Siebe : Germanische Sprachen lesen lernen (2007)

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See detailLe péché par la langue. Pour traduire Hamann
Droixhe, Daniel ULg

in Pot, O. (Ed.) Origines du langage : Une encyclopédie poétique (2007)

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See detailDevelopment Of A New Probe For Specific And Sensitive Detection Of 'Candidatus Phytoplasma Mali' In Inoculated Apple Trees
Aldaghi, M.; Massart, Sébastien ULg; Roussel, S. et al

in Annals of Applied Biology (2007), 151(2), 251-258

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See detailA stress-strain framework for modelling the behaviour of unsaturated soils under non-isothermal conditions.
François, Bertrand ULg; Lyesse, Laloui

in Springer Proceedings in Physics 113, Theoretical and Numerical Unsaturated Soils Mechanics (2007)

This paper addresses a new, unified thermo-mechanical constitutive model for unsaturated soils through a coupled study. In the context of elastoplasticity and the critical state theory, the model uses the ... [more ▼]

This paper addresses a new, unified thermo-mechanical constitutive model for unsaturated soils through a coupled study. In the context of elastoplasticity and the critical state theory, the model uses the concepts of multimechanism and bounding surface theory. This advanced constitutive approach involves thermo-plasticity of saturated and unsaturated soils. Bishop’s effective stress framework is adopted to represent the stress state in the soil. This stress is linked to the water retention curve, which is represented by an elasto-plastic model. Attention is focused particularly on the coupling relations inferred from this unified thermohydro-mechanical (THM) study. Finally, the theoretical aspects of the paper are supported by comparisons between numerical simulations and experimental results. [less ▲]

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See detailEmerging therapeutic agents for onychomycosis.
Pierard, Gérald ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg et al

in Expert Opinion on Emerging Drugs (2007), 12(3), 345-53

Onychomycosis is a frequent disorder that represents the most prevalent fungal infection, particularly among older individuals. Diverse fungi of the dermatophyte, non-dermatophyte mold and yeast families ... [more ▼]

Onychomycosis is a frequent disorder that represents the most prevalent fungal infection, particularly among older individuals. Diverse fungi of the dermatophyte, non-dermatophyte mold and yeast families have been reported to be responsible for onychomycosis. The output from the pharmaceutical industry of new antifungals to treat onychomycosis has been limited over the last decade. Present treatment options include both oral and topical drugs, with oral therapies giving better outcomes. However, neither of these treatment options provides high cure rates that are durable. At present, azoles and allylamines are keeping the pivotal roles. New derivatives with a favorable risk-benefit ratio and new formulations of older azoles seem to be promising. Thus, ongoing drug development activities have focused on novel delivery technologies to facilitate incorporation of existing antifungal drugs inside the nail plate and the discovery of new active antifungals. [less ▲]

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See detailComposition of degumming residues from oil physical refining : valorization for food application
Pierart, Céline ULg; Cavillot, Véronique; Kervyn de Meerendré, M. et al

Poster (2007)

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See detailRegional variability in stratum corneum reactivity to antiseptic formulations.
Quatresooz, Pascale ULg; Xhauflaire, Emmanuelle ULg; Pierard, Claudine ULg et al

in Contact Dermatitis (2007), 56(5), 271-3

Skin does not react in an identical way to the action of chemicals over all anatomic sites. Accordingly, distinct regional differences have been described in relation to irritancy. The present study ... [more ▼]

Skin does not react in an identical way to the action of chemicals over all anatomic sites. Accordingly, distinct regional differences have been described in relation to irritancy. The present study assesses the regional variations of stratum corneum (SC) reactivity to 3 proprietary antiseptic solutions (povidone iodine (PVP-I), 70 mg/ml and 100 mg/ml, and chlorhexidine digluconate 50 mg/ml) using the corneoxenometry (CXM) bioassay. SC was harvested from the volar forearm, the forehead and the back in 30 young adults. Each SC sample was covered by one of the neat test product or deionized water for 2 hr at 20 degrees C. The intrinsic staining property of each antiseptic on SC was assessed by reflectance colorimetry. For the CXM bioassay, samples were then stained by a toluidine blue-basic fuschin solution in order to show protein denaturation induced by the test products. The colorimetric index of mildness (CIM = L*- Chroma C*) was measured by colorimetry. Data show that PVP-I 100 mg/ml was the least reactive antiseptic to the SC. It was significantly milder than the 2 other antiseptics. [less ▲]

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See detailBiting Midges Overwintering In Belgium
Losson, Bertrand ULg; Mignon, Bernard ULg; Paternostre, Julien ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2007), 160(13), 451-452

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See detailLocked-in syndrome et états de conscience altérée: comment détecter la conscience?
Vanhaudenhuyse, Audrey ULg; Bruno, Marie-Aurélie ULg; Schnakers, Caroline ULg et al

in Pellas, Frederique; Kiefer, C; Weiss, JJ (Eds.) et al Eveil de coma et états limites (2007)

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See detailSuperfluidity versus Anderson localization in a dilute Bose gas
Paul, T.; Schlagheck, Peter ULg; Leboeuf, P. et al

in Physical Review Letters (2007), 98(21),

We consider the motion of a quasi-one-dimensional beam of Bose-Einstein condensed particles in a disordered region of finite extent. Interaction effects lead to the appearance of two distinct regions of ... [more ▼]

We consider the motion of a quasi-one-dimensional beam of Bose-Einstein condensed particles in a disordered region of finite extent. Interaction effects lead to the appearance of two distinct regions of stationary flow. One is subsonic and corresponds to superfluid motion. The other one is supersonic and dissipative and shows Anderson localization. We compute analytically the interaction-dependent localization length. We also explain the disappearance of the supersonic stationary flow for large disordered samples. [less ▲]

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See detailL'ozone: une alternative au traitement chirurgical de la carie ?
Guéders, Audrey; Geerts, Sabine ULg

in Actualités Dentaires de l'Université de Liège (2007), 37

L'ozone possède des propriétés intéressantes tant dans le domaine médical que dans le domaine de la dentisterie. Ce gaz est capable d'éradiquer un certain nombre de bactéries, de virus et de champignons ... [more ▼]

L'ozone possède des propriétés intéressantes tant dans le domaine médical que dans le domaine de la dentisterie. Ce gaz est capable d'éradiquer un certain nombre de bactéries, de virus et de champignons après seulement 5 secondes de son application. Depuis quelques années, la firme Kavo propose un disposif (HealOzone®) générateur d'ozone spécialement conçu pour traiter les lésions carieuses non cavitaires. Cet article fait le point sur les connaissances actuelles concernant l'utilisation de l'ozone dans le traiement des caries débutantes. [less ▲]

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See detailNonexponential decay of Bose-Einstein condensates: a numerical study based on the complex scaling method
Schlagheck, Peter ULg; Wimberger, S.

in Applied Physics B : Lasers & Optics (2007), 86(3), 385-390

We study the decay dynamics of an interacting Bose-Einstein condensate in the presence of a metastable trapping potential from which the condensate can escape via tunneling through finite barriers. The ... [more ▼]

We study the decay dynamics of an interacting Bose-Einstein condensate in the presence of a metastable trapping potential from which the condensate can escape via tunneling through finite barriers. The time-dependent decay process is reproduced by means of the instantaneous decay rates of the condensate at a given population of the quasi-bound state, which are calculated with the method of complex scaling. Both for the case of a double-barrier potential as well as for the case of a tilted periodic potential, we find pronounced deviations from a monoexponential decay behavior, which would generally be expected in the absence of the atom-atom interaction. [less ▲]

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See detailLes effets redistributifs des systèmes de retraite en Europe
Lefebvre, Mathieu ULg

in Revue Française d'Economie (2007)

Les systèmes de retraite varient d’un pays à l’autre de l’Union Européenne selon différentes caractéristiques. Mais tous effectuent une certaine redistribution au sein des cohortes d’individus. Cet ... [more ▼]

Les systèmes de retraite varient d’un pays à l’autre de l’Union Européenne selon différentes caractéristiques. Mais tous effectuent une certaine redistribution au sein des cohortes d’individus. Cet article compare les performances redistributives intragénérationnelles des retraites publiques en utilisant les données du Luxembourg Income Study. L’analyse montre qu’il existe une grande variabilité entre les pays mais que ces différences peuvent être expliquée en partie par les caractéristiques propres aux systèmes. Il est aussi démontré que la redistribution ne favorise pas l’ensemble de la population retraitée de la même manière et que les femmes les plus âgées constituent la catégorie la moins favorisée. [less ▲]

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See detailTime-domain homogenization of windings in 2-D finite element models
Gyselinck, Johan; V Sabariego, Ruth ULg; Dular, Patrick ULg

in IEEE Transactions on Magnetics (2007), 43(4), 1297-1300

In this paper, the authors propose an original time-domain extension of the frequency-domain homogenization of multiturn windings in finite element (FE) models. For the winding type in hand (e.g., round ... [more ▼]

In this paper, the authors propose an original time-domain extension of the frequency-domain homogenization of multiturn windings in finite element (FE) models. For the winding type in hand (e.g., round conductor with hexagonal packing), an elementary FE model is used for determining dimensionless frequency and time-domain coefficients regarding skin and proximity effect. These coefficients are readily utilized for homogenizing the winding in the FE model of the complete device. The method is successfully applied to an axisymmetric 103-turn inductor. The results agree very well with those obtained by an accurate but very expensive FE model in which all turns are finely discretized. [less ▲]

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See detailA systems biology perspective of apoptosis signalling
Bullinger, Eric ULg

Conference (2007)

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See detailEarly to Middle Devonian miospores from northern Saudi Arabia
Breuer, P.; Al-Ghazi, A.; Al-Ruwaili, M. et al

in Revue de Micropaléontologie (2007), 50

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