References of "2007"
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See detailPotent inhibition of genital herpesvirus infection in goats by cidofovir
Tempesta, Maria; Camero, Michele; Bellacicco, Anna Lucia et al

in Antiviral Therapy (2007), 12(6), 977-979

Background: Like human herpesvirus 2 (HHV-2) in humans, infection by caprine herpesvirus 1 in goats is associated with genital lesions, and this provides a unique model to study the efficacy and effects ... [more ▼]

Background: Like human herpesvirus 2 (HHV-2) in humans, infection by caprine herpesvirus 1 in goats is associated with genital lesions, and this provides a unique model to study the efficacy and effects of anti-herpetic drugs. Methods: The antiviral activity of cidofovir was assessed in goats infected experimentally, using various therapeutic protocols. Results: Topic administration of cidofovir 1% cream prevented the onset of virus-induced genital lesions and drastically reduced virus shedding. Conclusion: Cidofovir appears to be a very efficient drug for the prevention of genital lesions caused by an alphaherpesvirus. [less ▲]

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See detailEvidence for a multiprotein gamma-2 herpesvirus entry complex.
Gillet, Laurent ULg; Stevenson, Philip G

in Journal of Virology (2007), 81(23), 13082-91

Herpesviruses use multiple virion glycoproteins to enter cells. How these work together is not well understood: some may act separately or they may form a single complex. Murine gammaherpesvirus 68 (MHV ... [more ▼]

Herpesviruses use multiple virion glycoproteins to enter cells. How these work together is not well understood: some may act separately or they may form a single complex. Murine gammaherpesvirus 68 (MHV-68) gB, gH, gL, and gp150 all participate in entry. gB and gL are involved in binding, gB and gH are conserved fusion proteins, and gp150 inhibits cell binding until glycosaminoglycans are engaged. Here we show that a gH-specific antibody coprecipitates gB and thus that gH and gB are associated in the virion membrane. A gH/gL-specific antibody also coprecipitated gB, implying a tripartite complex of gL/gH/gB, although the gH/gB association did not require gL. The association was also independent of gp150, and gp150 was not demonstrably bound to gB or gH. However, gp150 incorporation into virions was partly gL dependent, suggesting that it too contributes to a single entry complex. gp150- and gL- gp150- mutants bound better than the wild type to B cells and readily colonized B cells in vivo. Thus, gp150 and gL appear to be epithelial cell-adapted accessories of a core gB/gH entry complex. The cell binding revealed by gp150 disruption did not require gL and therefore seemed most likely to involve gB. [less ▲]

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See detailPro- and antigelatinolytic activities in the serum and airways of cats with experimentally-induced asthma
Leemans, Jérôme ULg; Kirschvink; Clercx, Cécile ULg et al

in Proceedings : 25th Symposium of the Veterinary Comparative Respiratory Society (2007)

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See detailPhylloblastia inexpectata (Verrucariaceae), a new species of foliicolous lichen from Western Europe and Madeira
Sérusiaux, Emmanuel ULg; Coppins, B. J.; Lucking, R.

in Lichenologist (2007), 39(Part 2), 103-108

Phylloblastia inexpectata Serus., Coppins

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See detailNew rationales for using TGFbeta inhibitors in radiotherapy.
Andarawewa, Kumari L.; Paupert, Jenny ULg; Pal, Anupama et al

in International journal of radiation biology (2007), 83(11-12), 803-11

PURPOSE: The first reports that ionizing radiation (IR) induces rapid and persistent activation of transforming growth factor beta1 (TGFbeta) were nearly two decades ago. Subsequent studies have shown ... [more ▼]

PURPOSE: The first reports that ionizing radiation (IR) induces rapid and persistent activation of transforming growth factor beta1 (TGFbeta) were nearly two decades ago. Subsequent studies have shown that TGFbeta is a major mediator of cellular and tissue responses to IR and have revealed novel facets of its complex biology. RESULTS: We and others have recently shown that inhibition of production or signaling of TGFbeta in epithelial cells modulates radiosensitivity and impedes activation of the DNA damage response program. The primary transducer of cellular response to DNA damage caused by ionizing radiation is the nuclear protein kinase ataxia telangiectasia mutated, whose activity is severely compromised when TGFbeta is inhibited. Thus, in conjunction, with its well-recognized contribution to normal tissue fibrosis, the role of TGFbeta in the genotoxic stress program provides a previously unsuspected avenue to modulate radiotherapy. CONCLUSIONS: We hypothesize that identification of the circumstances and tumors in which TGFbeta manipulation enhances tumor cell radiosensitivity, while protecting normal tissues, could significantly increase therapeutic index. [less ▲]

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See detailRimonabant as an adjunct therapy in overweight/obese patients with type 2 diabetes.
Scheen, André ULg; Van Gaal, Luc F

in European Heart Journal (2007), 28(11), 1401-21402

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See detailLe traitement biologique des maladies inflammatoires à médiation immune. Le cas de la dermatologie et de la rhumatologie
Von Frenckell, Christian ULg; Henno, Audrey ULg; de LA BRASSINNE, Michel ULg et al

in Revue Médicale de Liège (2007), 62(Spec No), 55-62

The pathophysiology and the treatment of diseases with clinical presentation so different as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and psoriasis vulgaris have been ... [more ▼]

The pathophysiology and the treatment of diseases with clinical presentation so different as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and psoriasis vulgaris have been revolutionized by the discovery of common pro-inflammatory effector mechanisms involving TNF-alpha and by the use of targeted therapies, the anti-TNF-alpha antibodies. In the past 10 years, our experience has helped several hundreds of patients who were treated with novel drugs, years before they became routinely available. In parallel tools of metrology were developped that can now be applied to the routine patient. Lastly, clinical research on these new drugs has also generated derived research works allowing the university hospital to satisfactorilly fullfil its specific missions. [less ▲]

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See detailSleep disorders and suicidal ideation in patients with depressive disorder.
Chellappa, Sarah Laxhmi ULg; Araujo, John Fontenele

in Psychiatry Research (2007), 153(2), 131-6

An intrinsic association between suicidal ideation and sleep disorders in patients with depressive disorder has been observed in recent studies. This study was conducted in order to examine the ... [more ▼]

An intrinsic association between suicidal ideation and sleep disorders in patients with depressive disorder has been observed in recent studies. This study was conducted in order to examine the relationship between suicidal ideation and sleep disorders, such as insomnia and excessive sleepiness, in outpatients with major depressive disorder. Seventy patients with diagnoses of major depressive disorder were interviewed and assessed with the Sleep Habits Questionnaire and the Beck Scale for Suicidal Ideation (SSI). Data analyses were performed through descriptive analysis, Students t-test, Chi-square test and logistic regression model, with a statistical significance of 5%. In this study, depressed patients had high SSI scores (6.12+/-2.67), particularly for active suicidal ideation (1.61+/-0.39) and specific plans for suicide components (1.51+/-0.40). Depressed patients with insomnia had significantly higher SSI scores (7.39+/-2.84), in relation to patients with excessive sleepiness (3.68+/-1.73). Furthermore it was observed that insomniac patients had significantly higher scores on the following components: active suicide ideation, specific plans for suicide and previous suicide attempts. The results of multivariate analysis showed that only insomnia had a significant association with suicidal ideation. Thus, sleep disturbances, particularly insomnia, should be considered in the assessment of suicidal risk in outpatients with depressive disorder. [less ▲]

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See detailFédéralisme
Beaufays, Jean ULg; Matagne, Geoffroy ULg

in Bourdeau; Merrill (Eds.) DicoPo : Dictionnaire de théorie politique (2007)

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See detailL'art de choisir: une question de style
Pâques, Michel ULg

in Annales de Droit de Louvain (2007), (4), 351-354

teaching of law, choice of topics to be taught, how to present them, academic freedom

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See detailSome Similar International Approaches for Engaging Instructors in Scholary Teaching and Conducting Research About Teaching
Cox, Milton; Olsson, Thomas; Poumay, Marianne ULg et al

in Enhancing Higher Education, Theory and Scholarship : Proceeding of the 30th HERDSA Annual Conference (2007)

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See detailRessemblances et dissemblances chez Didi-Huberman
Hagelstein, Maud ULg

in Lenain, Thierry; Lories, Danielle (Eds.) Mimèsis. Approches actuelles (2007)

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See detailExiste-t-il une "memoire therapeutique" en prevention cardiovasculaire?
Scheen, André ULg

in Revue Médicale Suisse (2007), 3(122), 1864-61868-9

The prevention of type 2 diabetes and of cardiovascular diseases is a major public health objective. Obviously life-style changes play a major role in this strategy. The Finnish Prevention Study recently ... [more ▼]

The prevention of type 2 diabetes and of cardiovascular diseases is a major public health objective. Obviously life-style changes play a major role in this strategy. The Finnish Prevention Study recently demonstrated that the remarkable diabetes prevention observed after a 4-year lifestyle intervention is maintained after a further 3-year period of follow-up without prolongation of the active intervention. Such a reminiscent effect may also be observed in the prevention of cardiovascular diseases with various pharmacological interventions: an ACE inhibitor (HOPE), a statin (4S), a fibrate (Helsinki Heart Study) or an intensive insulin therapy in type I diabetic patients (DCCT-EDIC). These intriguing results argue for a long-term memory of previous therapeutic interventions in cardiovascular prevention. [less ▲]

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See detailMapping, fine mapping, and molecular dissection of quantitative trait loci in domestic animals
Georges, Michel ULg

in Annual Review of Genomics & Human Genetics (2007), 8

Artificial selection has created myriad breeds of domestic animals, each characterized by unique phenotypes pertaining to behavior, morphology, physiology, and disease. Most domestic animal populations ... [more ▼]

Artificial selection has created myriad breeds of domestic animals, each characterized by unique phenotypes pertaining to behavior, morphology, physiology, and disease. Most domestic animal populations share features with isolated founder populations, making them well suited for positional cloning. Genome sequences are now available for most domestic species, and with them a panoply of tools including high-density single-nucleotide polymorphism panels. As a result, domestic animal populations are becoming invaluable resources for studying the molecular architecture of complex traits and of adaptation. Here we review recent progress and issues in the positional identification of genes underlying complex traits in domestic animals. As many phenotypes studied in animals are quantitative, we focus on mapping, fine mapping, and cloning of quantitative trait loci. [less ▲]

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See detailGlucosamine and chondroitin sulfate as therapeutic agents for knee and hip Osteoarthritis
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Drugs & Aging (2007), 24(7), 573-580

Osteoarthritis (OA), the most common form of arthritis, is a public health problem throughout the world. Several entities have been carefully investigated for the symptomatic and structural management of ... [more ▼]

Osteoarthritis (OA), the most common form of arthritis, is a public health problem throughout the world. Several entities have been carefully investigated for the symptomatic and structural management of OA. This review evaluates published studies of the effect of glucosamine salts and chondroitin sulfate preparations on the progression of knee or hip OA. Despite multiple double-blind, controlled clinical trials of the use of glucosamine and chondroitin sulfate in OA, controversy regarding the efficacy of these agents with respect to symptomatic improvement remains. Several potential confounders, including placebo response, use of prescription medicines versus over-the-counter pills or food supplements, or use of glucosamine sulfate versus glucosamine hydrochloride, may have relevance when attempting to interpret the seemingly contradictory results of different clinical trials. The National Institutes of Health-sponsored GAIT (Glucosamine/chondroitin Arthritis Intervention Trial) compared placebo, glucosamine hydrochloride, chondroitin sulfate, a combination of glucosamine and chondroitin sulfate and celecoxib in a parallel, blinded 6-month multicentre study of patients with knee OA. This trial showed that glucosamine hydrochloride and chondroitin sulfate alone or in combination did not reduce pain effectively in the overall group of patients with OA of the knee. However, exploratory analyses suggest that the combination of glucosamine hydrochloride and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain. For decades, the traditional pharmacological management of OA has been mainly symptomatic. However, in recent years, several randomised controlled studies have assessed the structure-modifying effect of glucosamine sulfate and chondroitin sulfate using plain radiography to measure joint space narrowing over years. There is some evidence to suggest a structure-modifying effect of glucosamine sulfate and chondroitin sulfate. On the basis of the results of recent randomised controlled trials and meta-analyses, we can conclude that glucosamine sulfate (but not glucosamine hydrochloride) and chondroitin sulfate have small-to-moderate symptomatic efficacy in OA, although this is still debated. With respect to the structure-modifying effect, there is compelling evidence that glucosamine sulfate and chondroitin sulfate may interfere with progression of OA. [less ▲]

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See detailThe impact and rotational light curves of Comet 9P/Tempel 1
Manfroid, Jean ULg; Hutsemekers, Damien ULg; Jehin, Emmanuel ULg et al

in Icarus: International Journal of Solar System Studies (2007), 191

UVES and HIRES high-resolution spectra of Comet 9P/Tempel 1 are used to investigate the impact and rotational light curves of various species with a view toward building a simple model of the distribution ... [more ▼]

UVES and HIRES high-resolution spectra of Comet 9P/Tempel 1 are used to investigate the impact and rotational light curves of various species with a view toward building a simple model of the distribution and activity of the sources. The emission by OH, NH, CN, C[SUB]3[/SUB], CH, C[SUB]2[/SUB], NH[SUB]2[/SUB], and OI, are analyzed, as well as the light scattered by the dust. It is found that a simple model reproduces fairly well the impact light curves of all species combining the production of the observed molecules and the expansion of the material throughout the slit. The impact light curves are consistent with velocities of 400 600 m/s. Their modeling requires a three-step dissociation sequence ``Grand-Parent --> Parent --> Daughter'' to produce the observed molecules. The rotational light curve for each species is explained in terms of a single model with three sources. The dust component can however not easily be explained that way. [less ▲]

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See detailCaractères généraux des matériaux
Courard, Luc ULg

Learning material (2007)

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See detailRefinement of two female fertility QTL using alternative phenotypes in French Holstein dairy cattle.
Guillaume, F.; Gautier, M.; Ben Jemaa, S. et al

in Animal Genetics (2007), 38(1), 72-4

Two quantitative trait loci (QTL) affecting female fertility were mapped in French dairy cattle. Phenotypes were non-return rates at 28, 56, 90 and 282 days after insemination. On chromosome 3, a QTL was ... [more ▼]

Two quantitative trait loci (QTL) affecting female fertility were mapped in French dairy cattle. Phenotypes were non-return rates at 28, 56, 90 and 282 days after insemination. On chromosome 3, a QTL was significant at 1% for non-return rate at 90 days, suggesting that it affects early fertility events. An analysis of SLC35A3, which causes complex vertebral malformation, excluded this gene from the QTL interval. On chromosome 7, a QTL was almost significant (P = 0.05) for non-return rate at 282 days. This QTL was associated with abortion and stillbirth problems. Use of appropriate phenotypes appeared important for fine-mapping QTL associated with fertility. [less ▲]

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