References of "2007"
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See detailInventaire des sources statistiques préalable à un observatoire de l'écomonie plurielle
Marée, Michel ULg; Gijselinckx, Caroline

Report (2007)

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See detailDes images et des récits qui disent le changement, des questions, des impasses et des possibles
Stassart, Pierre M ULg; Lecomte, Nadége

in Regards croisés (2007)

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See detailCharacteristics of familial isolated pituitary adenomas (FIPA) - Review
Daly, Adrian ULg; Vanbellinghen, Jean-François ULg; Beckers, Albert ULg

in Expert Review of Endocrinology & Metabolism (2007), 2(6), 725-733

The familial occurrence of pituitary adenomas has been recognized for many years and currently accounts for approximately 5% of all cases. Molecular, genetic and clinical features of familial pituitary ... [more ▼]

The familial occurrence of pituitary adenomas has been recognized for many years and currently accounts for approximately 5% of all cases. Molecular, genetic and clinical features of familial pituitary adenomas have been well characterized in multiple endocrine neoplasia type 1 (MEN-1) and Carney's complex (CNC), which account for the majority of familial pituitary tumor cases. These conditions are caused by MEN1 and PRKAR1A gene mutations, respectively, and the clinical and pathological features of pituitary pathology in these diseases differ from those of sporadic pituitary tumors. Familial acromegaly has been recognized for many years and, more recently, the clinical features of this clinical phenotype, referred to as isolated familial somatotropinoma, have been clarified. Over the past decade, the concept of non-MEN-1/CNC familial pituitary tumors has been expanded significantly to include all phenotypes, a condition known as familial isolated pituitary adenomas (FIPA). In FIPA, tumors can present homogeneously (same phenotype) or heterogeneously (different tumor phenotypes) within the same family. Compared with sporadic pituitary adenomas, patients with FIPA have a younger age at diagnosis and have larger tumors. The clinical features of FIPA differ from those of MEN-1 in terms of a higher frequency of somatotropinomas and a lower frequency of prolactinomas. The recent discovery of the involvement of mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene in association with pituitary tumors has provided new information regarding potential mechanisms of tumorigenesis in FIPA patients. While very infrequent in sporadic pituitary tumors, approximately 15% of FIPA patients have AIP mutations, rising to half of patients with familial acromegaly. In this review, we detail the clinical features of FIPA and discuss tumor pathology and genetic findings in this increasingly recognized clinical condition. [less ▲]

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See detailEtude d'impact de la MTR en Région wallonne
Delille, Nicolas ULg

Report (2007)

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See detailAdaptive Patch Features for Object Class Recognition with Learned Hierarchical Models
Scalzo, Fabien; Piater, Justus ULg

in 2nd Beyond Patches Workshop (2007)

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See detailSequential Variational Inference for Distributed Multi-Sensor Tracking and Fusion
Du, Wei ULg; Piater, Justus ULg

in The 10th International Conference on Information Fusion (2007)

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See detailGaseous emissions during the fattening of pigs kept either on fully slatted floor or on straw flow
Philippe, François-Xavier ULg; Laitat, Martine ULg; Canart, Bernard et al

in Animal (2007), 1(1), 1515-1523

The aim of this study was to compare the environmental impact of the straw-flow system for fattening pigs with the slatted-floor system by measuring pollutant gas emissions such as ammonia (NH3), nitrous ... [more ▼]

The aim of this study was to compare the environmental impact of the straw-flow system for fattening pigs with the slatted-floor system by measuring pollutant gas emissions such as ammonia (NH3), nitrous oxide (N2O), methane (CH4) and carbon dioxide (CO2), manure nitrogen (N) content and emissions of water vapour (H2O). Three successive batches of 32 pigs were fattened. For each batch, pigs were allotted to two groups raised in separated rooms fitted either with a concrete totally slatted-floor system (0.75 m(2) per pig) or with a straw-flow system (0.79 m(2) per pig). With this last system, pigs were kept on a sloped floor, straw being provided daily at the top of the pen. Throughout the fattening period, about 34.4 kg of straw were supplied per pig. The straw, mixed with dung, travelled down the slope by pig motion and went out of the pen to a scraped passage. The solid fraction was scraped every day, stored in a heap in the room and removed every month, 1 week before each period of gaseous emission measurement. The liquid fraction was automatically pumped from the scraped passage into a hermetic tank, which was emptied at the end of each fattening period. Rooms were ventilated mechanically in order to maintain a constant ambient temperature. Once a month, the emissions of NH3, N2O, CH4, CO2 and H2O were measured hourly for 6 consecutive days via infrared photoacoustic detection. Mean daily emissions per pig fattened on the slatted floor or on the sloped floor were, respectively, 4.98 and 13.31 g NH3, 0.67 and 0. 68 g N2O, 15.2 and 8.88 g CH4, 548 g and 406 g CO2 equivalents, 1.61 and 1.77 kg CO2 and 2.33 and 2.95 kg H2O. Except for N2O emissions, all the differences were statistically significant (P < 0.001). From the slatted-floor system, the amount of slurry removed per fattening period was on average 256 kg per pig. From the straw-flow system, solid manure amounted on average to 209 kg per pig and liquid manure to 53 kg per pig. The total N-content of the manure was 2.23 kg N per pig with the straw-flow system (solid and liquid manure) v. 3.26 kg N per pig for slurry from the slatted-floor system. This reduction of 30% observed with the sloped floor was mainly explained by the higher level of NH3-N emissions. [less ▲]

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See detailMourir au Pays des deux Fleuves. L'au-delà mésopotamien d'après les sources sumériennes et akkadiennes
Van der Stede, Véronique ULg

Book published by Peeters (2007)

 Cet ouvrage aborde la question des croyances mésopotamiennes en matière d’au-delà. Comment les Mésopotamiens concevaient-ils la mort ? Sous quelle forme les défunts survivaient-ils ? Comment les ... [more ▼]

 Cet ouvrage aborde la question des croyances mésopotamiennes en matière d’au-delà. Comment les Mésopotamiens concevaient-ils la mort ? Sous quelle forme les défunts survivaient-ils ? Comment les Mésopotamiens percevaient-ils le monde des morts? Qui étaient les divinités des Enfers ? Quelles étaient les conditions de survie des trépassés ? Telles sont entre autres les questions qui sont envisagées dans ce livre à travers l’analyse de sources textuelles en langues akkadienne et sumérienne. [less ▲]

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See detailMulti-Camera People Tracking by Collaborative Particle Filters and Principal Axis-Based Integration
Du, Wei ULg; Piater, Justus ULg

in Asian Conference on Computer Vision (2007)

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See detailLipodystrophy reactions to insulin: effects of continuous insulin infusion and new insulin analogs.
Radermecker, Régis ULg; Pierard, Gérald ULg; Scheen, André ULg

in American Journal of Clinical Dermatology (2007), 8(1), 21-8

Management of diabetes mellitus can be responsible for cutaneous adverse events. For example, lipoatrophy or lipohypertrophy can develop at the site of insulin injections. Lipohypertrophy remains a ... [more ▼]

Management of diabetes mellitus can be responsible for cutaneous adverse events. For example, lipoatrophy or lipohypertrophy can develop at the site of insulin injections. Lipohypertrophy remains a frequent complication of insulin therapy irrespective of the insulin source and mode of administration. Lipoatrophy at insulin injection sites is considered to be an immune complex-mediated inflammatory lesion; however, it has become a rare event since the advent of human insulin. Nowadays, continuous subcutaneous insulin infusion (CSII) using a portable pump and/or injections of insulin analogs with an altered amino acid sequence compared with native insulin may cause lipodystrophy in diabetic patients. Some case reports describe the recovery of lipoatrophy following the use of CSII and/or short-acting insulin analogs. Conversely, exceptional cases of lipoatrophy have occurred in patients receiving lispro insulin analog via CSII. Lipodystrophy reactions remain a potential problem when managing diabetic patients with new insulin therapy technologies. [less ▲]

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See detailThe bone mineralization density distribution as a fingerprint of the mineralization process
Ruffoni, Davide ULg; Fratzl, P.; Roschger, P. et al

in BONE (2007), 40(5), 1308-1319

The inhomogeneous mineral content and its topographical distribution on a microscopic scale are major determinants of the mechanical quality of trabecular bone. The kinetics of bone tissue deposition and ... [more ▼]

The inhomogeneous mineral content and its topographical distribution on a microscopic scale are major determinants of the mechanical quality of trabecular bone. The kinetics of bone tissue deposition and resorption together with the kinetics of the mineralization process determine the distribution of mineral in the tissue. The heterogeneity of the mineral content is described by the well-established bone mineralization density distribution (BMDD), which is experimentally accessible, e.g., using quantitative electron backscattering imaging (qBEI). In the present work, we demonstrate that the shape of the BMDD histogram of trabecular bone reflects directly the mineralization kinetics. Based on the experimental BMDD data of trabecular bone from healthy human adults and using a mathematical model for the remodeling and the mineralization process, the following main results were obtained. The peaked BMDD reflects necessarily a two-phase mineralization process with a fast primary phase and a slow secondary phase where the corresponding time constants differ three orders of magnitude. The obtained mineralization law, which describes the increase in the mineral content in a bone packet as a function of time, provides information not only about the initial mineralization surge, but also about the slow increase afterwards on the time scale of years. In addition to the mineralization kinetics the turnover rate of the remodeling process has a strong influence on the peak position and the shape of the BMDD. The described theoretical framework opens new possibilities for an analysis of experimentally measured BMDDs with respect to changes caused by diseases or treatments. It a] lows addressing whether changes in the BMDD have to be attributed to a variation in the turnover rate which consequently affects the density distribution or to a primary disorder in the mineralization process most likely reflecting alterations of the organic matrix. This is of important clinical interest because it helps to find therapeutic approaches directly targeting the primary etiological defects to correct the patients' BMDD towards normal BMDD. (c) 2007 Elsevier Inc. All rights reserved. [less ▲]

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See detailp27Kip1 independently promotes neuronal differentiation and migration in the cerebral cortex.
Nguyen, Laurent ULg; Besson, A.; Heng, J Ik-Tsen et al

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2007), 162(5-6), 310-4

The generation of glutamatergic neurons by stem and progenitor cells is a complex process involving the tight coordination of multiple cellular activities, including cell cycle exit, initiation of ... [more ▼]

The generation of glutamatergic neurons by stem and progenitor cells is a complex process involving the tight coordination of multiple cellular activities, including cell cycle exit, initiation of neuronal differentiation and cell migration. The mechanisms that integrate these different events into a coherent program are not well understood. Here we show that the cyclin-dependent kinase inhibitor p27Kip1 plays an important role in neurogenesis in the mouse cerebral cortex, by promoting the differentiation and radial migration of cortical projection neurons. Importantly, p27Kip1 promotes neuronal differentiation and neuronal migration via two distinct mechanisms, which are themselves independent of the cell cycle regulatory function of p27Kip1. p27Kip1 inactivation by gene targeting or RNA interference results in neuronal differentiation and radial migration defects, demonstrating that p27Kip1 regulates cell migration in vivo. The differentiation defect, but not the migration defect, is rescued by overexpression of the proneural gene Neurogenin 2. p27Kip1 acts by stabilizing Neurogenin 2 protein, an activity carried by the N-terminal half of the protein. The migration defect resulting from p27Kp1 inactivation is rescued by blocking RhoA signalling, an activity that resides in the c-terminal half of p27Kip1. Thus, p27Kip1 plays a key role in cortical development, acting as a modular protein that independently regulates and couples multiple cellular pathways contributing to neurogenesis. [less ▲]

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See detailBrain responses to violet, blue, and green monochromatic light exposures in humans: prominent role of blue light and the brainstem
Vandewalle, Gilles ULg; Schmidt, Christina ULg; Albouy, Geneviève ULg et al

in PLoS ONE (2007), 2(11), 1247

BACKGROUND: Relatively long duration retinal light exposure elicits nonvisual responses in humans, including modulation of alertness and cognition. These responses are thought to be mediated in part by ... [more ▼]

BACKGROUND: Relatively long duration retinal light exposure elicits nonvisual responses in humans, including modulation of alertness and cognition. These responses are thought to be mediated in part by melanopsin-expressing retinal ganglion cells which are more sensitive to blue light than violet or green light. The contribution of the melanopsin system and the brain mechanisms involved in the establishment of such responses to light remain to be established. METHODOLOGY/PRINCIPAL FINDINGS: We exposed 15 participants to short duration (50 s) monochromatic violet (430 nm), blue (473 nm), and green (527 nm) light exposures of equal photon flux (10(13)ph/cm(2)/s) while they were performing a working memory task in fMRI. At light onset, blue light, as compared to green light, increased activity in the left hippocampus, left thalamus, and right amygdala. During the task, blue light, as compared to violet light, increased activity in the left middle frontal gyrus, left thalamus and a bilateral area of the brainstem consistent with activation of the locus coeruleus. CONCLUSION/SIGNIFICANCE: These results support a prominent contribution of melanopsin-expressing retinal ganglion cells to brain responses to light within the very first seconds of an exposure. The results also demonstrate the implication of the brainstem in mediating these responses in humans and speak for a broad involvement of light in the regulation of brain function. [less ▲]

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See detailEvaluation : réponses à des questions qui dérangent
Vandoorne, Chantal ULg

in La Santé de l'Homme (2007), (390), 24-25

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See detailThe Pregnancy-Associated Glycoproteins: Biochemical Aspects and Clinical Application for Pregnancy Follow-up
Melo de Sousa, Noelita ULg; Barbato, O.; Bella, Amina ULg et al

Conference (2007)

Pregnancy diagnosis is an important part in reproduction management of ruminants. In the last years, a large polymorphic family of placenta-expressed proteins has been discovered in ruminant species and ... [more ▼]

Pregnancy diagnosis is an important part in reproduction management of ruminants. In the last years, a large polymorphic family of placenta-expressed proteins has been discovered in ruminant species and used for pregnancy diagnosis. Members of this family are named pregnancy-associated glycoproteins (PAG), being synthesized in the mono- and binucleate cells of the ruminant’s trophectoderm. Part of them are released in the maternal blood circulation where they can be assayed by different laboratory techniques. Due to large variety of expressed molecules and to large variations in the post-translational processing of the PAG, different immuno-systems present different ability to quantify the PAG released in blood. The sensitivity (92 to 100%) and specificity of PAG radioimmunoassay when used for pregnancy diagnosis are very high. The assay of PAG can also bring very interesting information for researchers working in programs focused on the study of embryonic and fetal mortalities, as well as on embryo biotechnology (ET, FIV, clonage), animal nutrition, or infections diseases resulting in pathologies affecting the pregnancy. [less ▲]

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See detailDetecting awareness in impaired states of consciousness
Vanhaudenhuyse, Audrey ULg

Conference (2007)

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