References of "2007"
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See detailMitoc-Malu Galben: étude de l'industrie lithique
Otte, Marcel ULg; Noiret, Pierre ULg; Chirica, Vasile et al

in Otte, Marcel; Chirica, Vasile; Haesaerts, Paul (Eds.) L'Aurignacien et le Gravettien de Mitoc-Malu Galben (Moldavie roumaine) (2007)

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See detailA new role for NF-kappaB in angiogenesis inhibition.
Tabruyn, Sébastien ULg; Griffioen, A. W.

in Cell Death & Differentiation (2007), 14(8), 1393-7

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See detailMirum dictu : les appositions de phrase chez les historiens latins
Longrée, Dominique ULg

in Bodelot, Colette (Ed.) "Éléments « asyntaxiques » ou hors structure dans l'énoncé latin" (2007)

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See detailCurrent and Future Trends in Dynamic and Mobile GIS
Drummond, Jane; Joao, Elsa; Billen, Roland ULg

in Drummond, Jane; Billen, Roland; Joao, Elsa (Eds.) et al Dynamic and Mobile GIS: Investigating Changes in Space and Time (2007)

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See detailPrevention of hip fractures in osteoporosis
Neuprez, Audrey ULg; Hiligsmann, Mickaël ULg; Bruyère, Olivier ULg et al

in Minerva Ortopedica e Traumatologica (2007), 58(5), 423-437

Hip fracture is the major clinical consequence of osteoporosis. It is linked with decreased life expectancy and quality of life, placing an ever increasing burden on health services. Few medications have ... [more ▼]

Hip fracture is the major clinical consequence of osteoporosis. It is linked with decreased life expectancy and quality of life, placing an ever increasing burden on health services. Few medications have unequivocally demonstrated their ability to reduce hip fracture risk in osteoporotic subjects. Daily alendronate and risedronate reduce hip fracture in patients with low bone mineral density and prevalent vertebral fractures. Intravenous bisphosphonates have been developed, in response to long-term poor adherence to oral anti-osteoporotic treatments. Once-yearly zoledronic acid reduces fracture rates at the spine, non-spine and hip locations. Strontium ranelate, the first drug to uncouple bone formation from bone resorption has also demonstrated its ability to reduce hip fractures in patients above 74 years old, with prevalent low bone mineral density. Calcium and vitamin D supplementation are prerequisite for the management of elderly subjects and should always been associated to anti-resorptive or bone forming agents. Non-pharmacological management of osteoporosis is recommended cannot be considered a substitute for pharmacological treatment of osteoporosis, not even in old age. [less ▲]

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See detailLa Posidonie, Cap Sur
Réseau Mer; Gobert, Sylvie ULg

Learning material (2007)

La posidonie sous le regard du scientifique, du gestionnaire, du plongeur, de l'historien, de l'élu du littoral, du plaisancier, du pêcheur, du baigneur et du juriste.

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See detailThe concept of Text Topology. Some applications to Verb-Form Distributions in Language Corpora
Longrée, Dominique ULg; Luong, Xuan; Juillard, Michel et al

in Literary & Linguistic Computing (2007), 22(2), 167-186

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See detailBulletin de la Commission royale pour la publication des Anciennes Lois et Ordonnances de Belgique
Marchandisse, Alain ULg

Book published by Ministère de la Justice (2007)

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See detailTemps verbaux et prose historique latine : à la recherche de nouvelles méthodes d'analyse statistique
Longrée, Dominique ULg; Mellet, Sylvie

in Purnelle, Gérald; Denooz, Joseph (Eds.) Ordre et cohérence, en latin, Communications présentées au 13e Colloque international de Linguistique latine, (Bruxelles-Liège, 4-9 avril 2005) (2007)

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See detailThe structure at 2 A resolution of Phycocyanin from Gracilaria chilensis and the energy transfer network in a PC-PC complex.
Contreras-Martel, Carlos; Matamala, Adelio; Bruna, Carola et al

in Biophysical Chemistry (2007), 125(2-3), 388-96

Phycocyanin is a phycobiliprotein involved in light harvesting and conduction of light to the reaction centers in cyanobacteria and red algae. The structure of C-phycocyanin from Gracilaria chilensis was ... [more ▼]

Phycocyanin is a phycobiliprotein involved in light harvesting and conduction of light to the reaction centers in cyanobacteria and red algae. The structure of C-phycocyanin from Gracilaria chilensis was solved by X-ray crystallography at 2.0 A resolution in space group P2(1). An interaction model between two PC heterohexamers was built, followed by molecular dynamic refinement. The best model showed an inter-hexamer rotation of 23 degrees . The coordinates of a PC heterohexamer (alphabeta)(6) and of the PC-PC complex were used to perform energy transfer calculations between chromophores pairs using the fluorescence resonance energy transfer approach (FRET). Two main intra PC ((I)beta(3)(82)-->(I)alpha(1)(84)-->(I)alpha(5)(84)-->(I)beta(6)(82) and (I)beta(3)(153)-->(I)beta(5)(153)) and two main inter PC ((I)beta(6)(82)-->(II)beta(3)(82) and (I)beta(5)(153)-->(II)beta(3)(153)) pathways were proposed based on the values of the energy transfer constants calculated for all the chromophore pairs in the hexamer and in the complex. [less ▲]

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See detailBlanc-Bleu Mixte: Spécificités des Elevages
Bastin, Catherine ULg; Mayeres, Patrick

Article for general public (2007)

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See detailTransgenic cassava resistance to African cassava mosaic virus is enhanced by viral DNA-A bidirectional promoter-derived siRNAs.
Vanderschuren, Hervé ULg; Akbergenov, Rashid; Pooggin, Mikhail M. et al

in Plant molecular biology (2007), 64(5), 549-57

Expression of double-stranded RNA (dsRNA) homologous to virus sequences can effectively interfere with RNA virus infection in plant cells by triggering RNA silencing. Here we applied this approach against ... [more ▼]

Expression of double-stranded RNA (dsRNA) homologous to virus sequences can effectively interfere with RNA virus infection in plant cells by triggering RNA silencing. Here we applied this approach against a DNA virus, African cassava mosaic virus (ACMV), in its natural host cassava. Transgenic cassava plants were developed to express small interfering RNAs (siRNA) from a CaMV 35S promoter-controlled, intron-containing dsRNA cognate to the common region-containing bidirectional promoter of ACMV DNA-A. In two of three independent transgenic lines, accelerated plant recovery from ACMV-NOg infection was observed, which correlates with the presence of transgene-derived siRNAs 21-24 nt in length. Overall, cassava mosaic disease symptoms were dramatically attenuated in these two lines and less viral DNA accumulation was detected in their leaves than in those of wild-type plants. In a transient replication assay using leaf disks from the two transgenic lines, strongly reduced accumulation of viral single-stranded DNA was observed. Our study suggests that a natural RNA silencing mechanism targeting DNA viruses through production of virus-derived siRNAs is turned on earlier and more efficiently in transgenic plants expressing dsRNA cognate to the viral promoter and common region. [less ▲]

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See detailAnalyse inverse en géotechnique : développement d’une méthode à base d’algorithmes génétiques
Levasseur, Séverine ULg

Doctoral thesis (2007)

La plupart des essais géotechniques in situ ne permettent pas d’identifier directement les paramètres constitutifs des couches de sol. L’utilisation de calculs par éléments finis pour dimensionner les ... [more ▼]

La plupart des essais géotechniques in situ ne permettent pas d’identifier directement les paramètres constitutifs des couches de sol. L’utilisation de calculs par éléments finis pour dimensionner les ouvrages est ainsi limitée par une mauvaise connaissance des propriétés mécaniques des sols. C’est dans ce contexte que se pose la problématique d’analyse inverse en géotechnique : quelles informations concernant les paramètres constitutifs du sol est-il possible d’obtenir à partir de mesures in situ? Ce travail concerne l’identification des paramètres de modèles constitutifs de sols par analyse inverse. Afin d’avoir une méthode d’identification adaptable à tout type de mesures (essais in situ ou ouvrages instrumentés), une méthode directe de résolution du problème inverse est développée. Des valeurs a priori sont données aux paramètres inconnus pour simuler le problème direct associé, à l’aide du code de calcul par éléments finis jusqu’à ce que l’écart entre les résultats du calcul numérique et les mesures in situ soit minimal. Les principales approches utilisées dans la littérature pour résoudre des problèmes d’optimisa- tion sont basées sur des méthodes de gradient. Ces méthodes supposent l’unicité de la solution du problème inverse. Or, les erreurs de modélisation et les incertitudes de mesures sont importantes en géotechnique. Il n’existe donc pas de solution exacte pour le problème inverse mais plutôt une infinité de solutions approchées. L’objectif de ce travail est de développer une méthode d’analyse inverse permettant d’identifier l’ensemble de ces solutions. Pour cela, nous avons choisi de baser la procédure d’analyse inverse sur un processus d’optimisation par algorithme génétique. Cette méthode, robuste et efficace, est connue pour sa capacité à résoudre des problèmes complexes. Nous montrons dans cette étude que l’analyse des solutions estimées par l’algorithme informe également sur la sensibilité des paramètres d’un modèle et sur l’existence possible de relations mathématiques entre ces paramètres. Suite à cela, nous proposons de décrire mathématiquement l’ensemble des solutions identifiées par l’algorithme génétique grâce à une étude statistique de type analyse en composantes principales. Cette étude montre que même si toutes les solutions d’un problème ne sont pas identifiées directement par l’algorithme génétique, leur exploitation par une analyse en composantes principales permet d’estimer l’ensemble des solutions du problème inverse. Cette méthode est développée à partir de quelques résultats obtenus sur des exemples synthétiques d’ouvrages de soutènement et d’essais pressiométriques. Puis, différentes applications réelles sur ces types d’essais et d’ouvrages géotechniques illustrent la pertinence de la méthode. [less ▲]

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See detailHans de Winiwarter (1875-1949) : un collectionneur d’art japonais en Belgique
Bawin, Julie ULg

in 7e congrès de l’Association des cercles francophones d’histoire et d’archéologie de Belgique, LIVe congrès de la fédération des cercles d’archéologie et d’histoire de Belgique (2007)

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See detailThe global modal parameterization for non-linear model-order reduction in flexible multibody dynamics
Bruls, Olivier ULg; Duysinx, Pierre ULg; Golinval, Jean-Claude ULg

in International Journal for Numerical Methods in Engineering (2007), 69(5), 948-977

In flexible multibody dynamics, advanced modelling methods lead to high-order non-linear differential-algebraic equations (DAEs). The development of model reduction techniques is motivated by control ... [more ▼]

In flexible multibody dynamics, advanced modelling methods lead to high-order non-linear differential-algebraic equations (DAEs). The development of model reduction techniques is motivated by control design problems, for which compact ordinary differential equations (ODEs) in closed-form are desirable. In a linear framework, reduction techniques classically rely on a projection of the dynamics onto a linear subspace. In flexible multibody dynamics, we propose to project the dynamics onto a submanifold of the configuration space, which allows to eliminate the non-linear holonomic constraints and to preserve the Lagrangian structure. The construction of this submanifold follows from the definition of a global modal parameterization (GMP): the motion of the assembled mechanism is described in terms of rigid and flexible modes, which are configuration-dependent. The numerical reduction procedure is presented, and an approximation strategy is also implemented in order to build a closed-form expression of the reduced model in the configuration space. Numerical and experimental results illustrate the relevance of this approach. Copyright (c) 2006 John Wiley [less ▲]

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See detailChronologie, céramique et statistique
Deru, Xavier ULg

in Rivet L. (Ed.) Actes de la Société française d’étude de la céramique en Gaule, Langres 2007 (2007)

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See detailQuand l’art contemporain s’empare de la mythologie
Bawin, Julie ULg

in catalogue de l’exposition "Icare" (2007)

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See detailMathematical modelling of growth factor induced bone regeneration: importance of angiogenesis
Van Oosterwyck, Hans; Vander Sloten, Jos; Geris, Liesbet ULg

in Tissue Engineering (2007)

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See detailAnalysis of alpha-synuclein, dopamine and parkin pathways in neuropathologically confirmed parkinsonian nigra.
Moran, L. B.; Croisier, E.; Duke, D. C. et al

in Acta Neuropathologica (2007), 113(3), 253-63

The identification of mutations that cause familial Parkinson's disease (PD) provides a framework for studies into pathways that may be perturbed also in the far more common, non-familial form of the ... [more ▼]

The identification of mutations that cause familial Parkinson's disease (PD) provides a framework for studies into pathways that may be perturbed also in the far more common, non-familial form of the disorder. Following this hypothesis, we have examined the gene regulatory network that links alpha-synuclein and parkin pathways with dopamine metabolism in neuropathologically verified cases of sporadic PD. By means of an in silico approach using a database of eukaryotic molecular interactions and a whole genome transcriptome dataset validated by qRT-PCR and histological methods, we found parkin and functionally associated genes to be up-regulated in the lateral substantia nigra (SN). In contrast, alpha-synuclein and ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) gene expression levels were significantly reduced in both the lateral and medial SN in PD. Gene expression for Septin 4, a member of the GTP-binding protein family involved in alpha-synuclein metabolism was elevated in the lateral parkinsonian SN. Additionally, catalase and mitogen-activated protein kinase 8 and poly(ADP-ribose) polymerase family member 1 (PARP1) known to function in DNA repair and cell death induction, all members of the dopamine synthesis pathway, were up-regulated in the lateral SN. In contrast, two additional PD-linked genes, glucocerebrosidase and nuclear receptor subfamily 4, group A, member 2 (NR4A2) showed reduced expression. We show that in sporadic PD, parkin, alpha-synuclein and dopamine pathways are co-deregulated. Alpha-synuclein is a member of all three gene regulatory networks. Our analysis results support the view that alpha-synuclein has a central role in the familial as well as the non-familial form of the disease and provide steps towards a pathway definition of PD. [less ▲]

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