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See detailImpaired iodide organification in autonomous thyroid nodules
Moreno-Reyes, Rodrigo; Tang, Bich-Ngoc-Thanh; Seret, Alain ULg et al

in Journal of Clinical Endocrinology and Metabolism (2007), 92(12), 4719-4724

Context: The clinical evolution of autonomous thyroid nodules (ATN) is unpredictable, and thyrotoxicosis is observed at variable nodule size. In vitro data suggest that hydrogen peroxide production is ... [more ▼]

Context: The clinical evolution of autonomous thyroid nodules (ATN) is unpredictable, and thyrotoxicosis is observed at variable nodule size. In vitro data suggest that hydrogen peroxide production is decreased in ATN, indicating intranodular iodide organification impairment. Objective: We aimed to determine iodide organification efficiency in ATN and its relationship with thyroid status in patients. Design: Forty-six patients with a single ATN on the I-123 thyroid scan were included in the study. Biological evaluation and iodine perchlorate (I-ClO4) discharge test were carried out in all subjects. Setting: The study took place at an academic hospital. Results: Among the 46 patients, 28 patients (61%) had a positive I-ClO4 discharge test with a mean +/- SD value of discharge of 42 +/- 13%, and 18 (39%) had a negative discharge test with mean +/- SD of 5 +/- 9%. In the group of patients with a negative discharge test but not in the group with a positive test, serum-free T-3 and free T-4 concentrations were significantly correlated with the I-123 uptake. The severity of hyperthyroidism was not different between both groups. Conclusions: Intranodular iodide organification was impaired in most patients with ATN. Whether differences in organification capability could predict the risk for evolution to overt hyperthyroidism in patients with ATN remains to be established. [less ▲]

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See detailInterictal abnormalities of gamma band activity in visual evoked responses in migraine: an indication of thalamocortical dysrhythmia?
Coppola, G.; Ambrosini, Anna; Di Clemente, L. et al

in Cephalalgia : An International Journal of Headache (2007), 27(12), 1360-1367

Between attacks, migraineurs lack habituation in standard visual evoked potentials (VEPs). Visual stimuli also evoke high-frequency oscillations in the gamma band range (GBOs, 20-35 Hz) assumed to be ... [more ▼]

Between attacks, migraineurs lack habituation in standard visual evoked potentials (VEPs). Visual stimuli also evoke high-frequency oscillations in the gamma band range (GBOs, 20-35 Hz) assumed to be generated both at subcortical (early GBOs) and cortical levels (late GBOs). The consecutive peaks of GBOs were analysed regarding amplitude and habituation in six successive blocks of 100 averaged pattern reversal (PR)-VEPs in healthy volunteers and interictally in migraine with (MA) or without aura patients. Amplitude of the two early GBO components in the first PR-VEP block was significantly increased in MA patients. There was a significant habituation deficit of the late GBO peaks in migraineurs. The increased amplitude of early GBOs could be related to the increased interictal visual discomfort reported by patients. We hypothesize that the hypofunctioning serotonergic pathways may cause, in line with the thalamocortical dysrhythmia theory, a functional disconnection of the thalamus leading to decreased intracortical lateral inhibition, which can induce dishabituation. [less ▲]

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See detailLe cas clinique du mois. Aspergillose pulmonaire: un cas d'aspergillose necrosante chronique
Golinval, Olivier ULg; Louis, Renaud ULg

in Revue Médicale de Liège (2007), 62(12), 704-6

Pulmonary aspergillosis are uncommon diseases. The clinical expression of which are depending on the immunological status. The spectrum of pulmonary aspergillosis goes from hypersensitization to the ... [more ▼]

Pulmonary aspergillosis are uncommon diseases. The clinical expression of which are depending on the immunological status. The spectrum of pulmonary aspergillosis goes from hypersensitization to the invasive and disseminated aspergillosis. We report here the clinical history of a patient with severe COPD and receiving regular oral corticoids who had a persistent lung infiltration. The infiltration became cavitary and proved to be a chronic necrotizing pneumonia due to Aspegillus fumigatus. The outcome was favourable thank to a treatment with voriconazole. [less ▲]

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See detailModel of electrostatic actuated deformable mirror using strongly coupled electro-mechanical finite element
Rochus, Véronique ULg; Golinval, Jean-Claude ULg; Mendez, C. et al

in Analog Integrated Circuits and Signal Processing (2007), 53(2-3), 129-135

The aim of this paper is to deal with multi-physics simulation of micro-electro-mechanical systems (MEMS) based on an advanced numerical methodology. MEMS are very small devices in which electric as well ... [more ▼]

The aim of this paper is to deal with multi-physics simulation of micro-electro-mechanical systems (MEMS) based on an advanced numerical methodology. MEMS are very small devices in which electric as well as mechanical and fluid phenomena appear and interact. Because of their microscopic scale, strong coupling effects arise between the different physical fields, and some forces, which were negligible at macroscopic scale, have to be taken into account. In order to accurately design such micro-electro-mechanical systems, it is of primary importance to be able to handle the strong coupling between the electric and the mechanical fields. In this paper, the finite element method (FEM) is used to model the strong coupled electro-mechanical interactions and to perform static and transient analyses taking into account large mesh displacements. These analyses will be used to study the behaviour of electrostatically actuated micro-mirrors. [less ▲]

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See detailInhibition of tumor growth and metastasis establishment by adenovirus-mediated gene transfer delivery of the antiangiogenic factor 16K hPRL
Nguyen, Ngoc-Quynh-Nhu ULg; Cornet, Anne ULg; Blacher, Silvia ULg et al

in Molecular Therapy : The Journal of the American Society of Gene Therapy (2007), 15(12), 2094-2100

Tumor metastases, the most fearsome aspect of cancer, are generally resistant to conventional therapies. Angiogenesis is a crucial aspect of tumor growth and metastatic dissemination. Antiangiogenic ... [more ▼]

Tumor metastases, the most fearsome aspect of cancer, are generally resistant to conventional therapies. Angiogenesis is a crucial aspect of tumor growth and metastatic dissemination. Antiangiogenic therapy, therefore, holds potential as an attractive strategy for inhibiting metastasis development. Human 16K PRL (16K hPRL), a potent inhibitor of angiogenesis, has been demonstrated to prevent tumor growth in two xenograft mouse models, but whether it also affects tumor metastasis is unknown. In this study we will investigate the ability of 16K hPRL to prevent the establishment of metastasis. We demonstrate that 16K hPRL administered via adenovirus-mediated gene transfer, inhibits tumor growth by 86% in a subcutaneous (SC) B16-F10 mouse melanoma model. Computer-assisted image analysis shows that 16K hPRL treatment results in a reduction of tumor-vessel length and width, leading to a 57% reduction of average vessel size. In a pre-established tumor model, moreover, 16K hPRL can significantly delay tumor development. Finally, for the first time, we provide evidence that 16K hPRL considerably reduces the establishment of B16-F10 metastasis in an experimental lung metastasis model. Both the number and size of metastases are reduced by 50% in 16K hPRL-treated mice. These results highlight a potential role for 16K hPRL in anticancer therapy for both primary tumors and metastases. [less ▲]

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See detailEtude comparative des performances de production laitiere de brebis de race Mouton Laitier Belge avec celles de brebis de race Lacaune.
Gillon, Alain ULg; Rondia, Pierre; Gengler, Nicolas ULg et al

in 14ièmes Recontres Recherches Ruminants, Paris, les 5 et 6 Décembre 2007 (2007, December)

La Wallonie compte une dizaine de producteurs de lait de brebis avec un cheptel variant de 30 à 250 individus par exploitation, pour la plupart de race « Mouton Laitier Belge » (MLB). Il s’agit d’un ... [more ▼]

La Wallonie compte une dizaine de producteurs de lait de brebis avec un cheptel variant de 30 à 250 individus par exploitation, pour la plupart de race « Mouton Laitier Belge » (MLB). Il s’agit d’un animal de type exclusivement laitier qui s’apparente fortement au mouton laitier frison dont l’effectif s’élève à un millier de têtes. La présence simultanée de brebis Lacaune (LAC) et de brebis MLB sur une même exploitation a permis la comparaison de leurs performances respectives grâce à une maîtrise du facteur « mode de conduite ». L’effectif restreint des populations étudiées constitue une limite à une extrapolation des résultats à l’ensemble des individus des races concernées mais donne néanmoins une certaine indication de leur potentiel de production respectif en région wallonne. [less ▲]

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See detailNonlinear Aeroelastic vibrations and galloping of iced conductor lines under wind.
Shklyarchuk, Fedor; Danilin, Alexander; Lilien, Jean-Louis ULg et al

in Proceedings of the 7th International Conference on Cable Dynamics (2007, December)

galloping model for one span single conductor dead ended.

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See detailA kinematic model for hysteretic dissipation of vibration energy for torsional damper and detuner.
Danilin, Alexander; Vinogradov, Alexander; Lilien, Jean-Louis ULg

in Lilien, Jean-Louis (Ed.) Proceedings of the 7th International Conference on Cable Dynamics (2007, December)

A description of the damping properties and model of a low frequency damper for power lines galloping.

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See detailNew insights into peripherin expression in cochlear neurons
Lallemend, François; Vandenbosch, Renaud ULg; Hadjab, S. et al

in Neuroscience (2007), 150(1), 212-222

Peripherin is an intermediate filament protein that is expressed in peripheral and enteric neurons. In the cochlear nervous system, peripherin expression has been extensively used as a differentiation ... [more ▼]

Peripherin is an intermediate filament protein that is expressed in peripheral and enteric neurons. In the cochlear nervous system, peripherin expression has been extensively used as a differentiation marker by preferentially labeling the type II neuronal population at adulthood, but yet without knowing its function. Since the expression of peripherin has been associated in time with the process of axonal extension and during regeneration of nerve fibers in other systems, it was of interest to determine whether peripherin expression in cochlear neurons was a static phenotypic trait or rather prone to modifications following nerve injury. In the present study, we first compared the expression pattern of peripherin and beta III-tubulin from late embryonic stages to the adult in rat cochlea. The staining for both proteins was seen before birth within all cochlear neurons. By birth, and for 2 or 3 days, peripherin expression was gradually restricted to the type II neuronal population and their projections. In contrast, from postnatal day (P) 10 onwards, while the expression of beta III-tubulin was still found in projections of all cochlear neurons, only the type I population had beta III-tubulin immunoreactivity in their cell bodies. We next investigated the expression of peripherin in axotomized cochlear neurons using an organotypic explant model. Peripherin expression was surprisingly re-expressed in a vast majority of neurons after axotomy. In parallel, the expression and localization of beta III-tubulin and peripherin in dissociated cultures of cochlear neurons were studied. Both proteins were distributed along the entire neuronal length but exhibited complementary distribution, especially within the projections. Moreover, peripherin immunoreactivity was still abundant in the growth cone, whereas that of beta III-tubulin was decreasing at this compartment. Our findings are consistent with a model in which peripherin plays an important structural role in cochlear neurons and their projections during both development and regenerative processes and which is compatible with the assumption that frequently developmentally regulated factors are reactivated during neuronal regeneration. [less ▲]

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See detailLactation effect on the trace element dynamics in northern elephant seals (Mirounga angustirostris)
Habran, Sarah ULg; Debier, Cathy; Lepoint, Gilles ULg et al

Conference (2007, November 30)

Northern elephant seals, Mirounga angustirostris, are exceptional mammals: females fast entirely during nursing while their pups may quadruple in weight over the 25-day suckling period. Females thus lose ... [more ▼]

Northern elephant seals, Mirounga angustirostris, are exceptional mammals: females fast entirely during nursing while their pups may quadruple in weight over the 25-day suckling period. Females thus lose approximately a third of body mass and produce energy-rich milk with a high fat content. Stable carbon and nitrogen isotope ratios (d13C and d15N used as diet markers) and total mercury concentrations (Hg) were measured in tissues (blood cells, serum, full blood, milk and blubber) from 20 mother-pup pairs on days 4 and 21 of lactation. A systematic difference was observed between isotopic values in blood cells and serum of the mothers, linked to diet and distinct biochemical composition between blood components. d13C differed between inner and outer blubber layers and were similar between inner blubber and milk. High Hg concentrations (up to 350 ng.g-1ww at the beginning of lactation) were found in the blood of mother elephant seals linked to their high d15N values in blood cells. Hg transfer through placenta and milk was observed between mothers and pups. A significant increase of blood Hg concentration in mothers (+285 ng.g-1ww) and a decrease in pups (-93 ng.g-1ww) were observed between days 4 and 21 of lactation. Both processes were explained by a remobilization of proteins and lipids during fasting and milk production in mothers and by a dilution of Hg in pups due to their high mass increase during this period. This study confirms that lactation modifies stable nitrogen isotope ratios in tissues, as well as mercury levels in blood from mothers and pups, and highlights the existence of a transplacental and transmammary transfer of mercury in northern elephant seals. Therefore, physiological processes and body condition should be considered carefully when interpreting stable isotope ratios and Hg concentrations in the framework of biomonitoring. [less ▲]

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See detailEtude dichronique et historique de l'évolution du trait de côte de la baie de Tanger (Maroc)
El Abdellaoui, Jamal Eddine ULg; Ozer, André ULg

in Télédétection  : Revue de Recherche et d'Application en Télédétection (2007), vol. 7(n° 1-2-3-4), 157-171

The diachronic analysis of air photos and Corona satellite images shows that the erosion of the sandy coast of Tangier bay occurred at variable speeds between 1972 and 1997. The period between 1972-1981 ... [more ▼]

The diachronic analysis of air photos and Corona satellite images shows that the erosion of the sandy coast of Tangier bay occurred at variable speeds between 1972 and 1997. The period between 1972-1981 shows generalized erosion with a rate of 4 m/year. The period of 1981-1997 registers a restoring of the average trend with the formation of three sectors, the first one in erosion with an average rate of 1,5 m/year, the second sector is stable and the third in accretion. Because of its remoteness from the production zones, the sandy beach evolves in a closed system. In fact, on the one hand, the construction of the harbour jetty intercepted the longshore drift generated by the west swell and, on the other hand, the development of the western hillside immobilized the sandy materials that do not contribute anymore to the current solid contribution. Finally, the longshore drift which redistributes the pebbles brought by the oued Halou is broken by the construction of a defence system. The fluvial discharges are henceforth immobilized between the breakwater and the eastern groyne and do not contribute to the sedimentary dynamics. This situation aggravates the impoverishment of the involved sedimentary stock. At present, the erosion that drew sediments of the beach from the most easterly beach to accrete that western portion can’t find more materials because of the erosion and of the quasitotal occupation of the beach. In fact, the western beach not nourished by sediments, will see its vulnerability increase gradually. The repairing of the beach further to successive storms is more difficult. This reality is already felt in 2006. On the other hand, a portion of the clayey coastal cliff of Tangier bay, considered as stable, sustains significant erosion. The mean rate of cliff retreat, recorded between 1981 and 1997, is estimated at 1,5m/year. The reconstructionof the natural coastal system and the monitoring of the successive developments in the bay show that the anthropization of the coast has unbalanced the system in an irreversible way. [less ▲]

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See detailThe Definition of the Concept of Tax
Bourgeois, Marc ULg

Conference (2007, November 29)

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See detailIsolation and identification of inulooligosaccharides resulting from inulin hydrolysis
Ronkart, Sebastien N; Blecker, Christophe ULg; Fourmanoir, Hélène et al

in Analytica Chimica Acta (2007), 604(1), 81-87

In this study, inulooligosaccharides (F-n-type inulin) resulting from the endo-inulinase hydrolysis of globe artichoke inulin were purified and characterized. The aim was to produce F-n oligomer standards ... [more ▼]

In this study, inulooligosaccharides (F-n-type inulin) resulting from the endo-inulinase hydrolysis of globe artichoke inulin were purified and characterized. The aim was to produce F-n oligomer standards with the intention of identifying them in the complex inulin chromatogram. Inulin was extracted from globe artichoke and presented a high average degree of polymerization (DP) of about 80 as determined by high-performance anion exchange chromatography coupled with pulsed amperometric detection (HPAEC-PAD). This inulin was hydrolyzed by a commercial endo-inulinase yielding a product with a very high F-n/GF(n), molecule ratio, thus limiting the interference of GF(n) during the purification process. High performance size exclusion chromatography was used to individually isolate and collect each retention peak corresponding to a specific oligomer. The purity of these fractions was checked by HPAEC-PAD and showed that relatively pure molecules were produced. Electrospray ionization mass spectrometry allowed the molecular weight determination of these purified oligomers and ascertained their DP as F-2, F-3 and F-4. These F2-4 standards were used with glucose, fructose, sucrose and GF(2-4) (commercially available) to spike commercial oligofructose products in order to determine the elution profile in the HPAEC-PAD chromatogram. [less ▲]

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