References of "2007"
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See detailInteraction between dendritic cells and nerve fibres in lymphoid organs after oral scrapie exposure
Dorban, Gauthier ULg; Defaweux, Valérie ULg; Demonceau, Christine ULg et al

in Virchows Archiv (2007), 451(6), 1057-1065

In transmissible spongiform encephalopathies (TSEs), the infectious agent, called PrPsc, an abnormal isoform of the cellular prion protein, accumulates and replicates in lymphoid organs before affecting ... [more ▼]

In transmissible spongiform encephalopathies (TSEs), the infectious agent, called PrPsc, an abnormal isoform of the cellular prion protein, accumulates and replicates in lymphoid organs before affecting the nervous system. To clarify the cellular requirements for the neuro-invasion of the scrapie agent from the lymphoid organs to the central nervous system, we have studied, by confocal microscopy, the innervations within Peyer's patches, mesenteric lymph nodes and the spleen of mice in physiological conditions and after oral exposure to prion. Contacts between nerve fibres and PrPsc-associated cells, dendritic cells (DCs) and follicular dendritic cells (FDCs), were evaluated in preclinical prion-infected mice. Using a double immunolabelling strategy, we demonstrated the lack of innervation of PrPsc-accumulating cells (FDCs). Contacts between nerve fibers and PrPsc-propagating cells (DCs) were detected in T-cell zones and cell-trafficking areas. This supports, for the first time, the possible implication of dendritic cells in the prion neuroinvasion process. [less ▲]

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See detailCaractérisation physiologique et biochimique du processus de vieillissement du tubercule de pomme de terre (Solanum tuberosum L.)
Delaplace, Pierre ULg

Doctoral thesis (2007)

Potato seed tuber is considered as a model organ to study plant ageing. Besides, its physiological age greatly influences germination pattern and thus agronomical performance. In order to unravel the ... [more ▼]

Potato seed tuber is considered as a model organ to study plant ageing. Besides, its physiological age greatly influences germination pattern and thus agronomical performance. In order to unravel the biochemical processes underlying ageing, potato seed tubers (cv. Bintje and Désirée) were stored at 4°C for 7 months and regularly sampled to assess both physiological and biochemical parameters. Physiological age markers (PAI, incubation period) evolution was measured and allowed us to define a reference frame more accurate than the chronological age. A correlation has also been established with the growth parameters (number of stems, duration before emergence). In parallel, two biochemical approaches allowed us to assay proteome and antioxidant system modifications occurring during ageing. Protein pattern evolution was assessed by DIGE after hot SDS extraction. During ageing, 93 spots were strictly up- or down- regulated while 4 others exhibited an abundance curve with a transient maximum. After manual picking of 43 selected spots based on their expression profile, 32 proteins were identified by MS/MS. Differentially expressed proteins are mainly involved in patatin catabolism, stress response, glycolysis, protein turn-over and lipid oxidation. A complementary targeted approach has then been set up based on the free radical ageing theory. SOD, CAT, APX and POX activities as well as ascorbate, glutathione, carotenoid and phenolic compound contents were measured during ageing. These data seem to indicate that the antioxidant system undergoes marked changes in response to an increased production of reactive oxygen species. However, no accumulation of oxidative damages has been observed on lipids and proteins. All these kinetic data allowed us to build an integrated ageing model. These results are discussed in the above-mentioned theoretical context. [less ▲]

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See detailBRCA1, BRCA2, TP53, and CDKN2A germline mutations in patients with breast cancer and cutaneous melanoma
Monnerat, C.; Chompret, A.; Kannengiesser, C. et al

in Familial Cancer (2007), 6(4), 453-461

Purpose From epidemiological studies it appears that breast cancer (BC) and cutaneous melanoma (CMM) in the same individual occur at a higher frequency than expected by chance. Genetic factors common to ... [more ▼]

Purpose From epidemiological studies it appears that breast cancer (BC) and cutaneous melanoma (CMM) in the same individual occur at a higher frequency than expected by chance. Genetic factors common to both cancers can be suspected. Our goal was to estimate the involvement of "high risk" genes in patients presenting these two neoplasia, selected irrespectively from family history and age at diagnosis. Experimental Design Eighty two patients with BC and CMM were screened for BRCA1, BRCA2, TP53, CDKN2A and CDK4 (exon 2) germline mutations. Results Deleterious mutations were identified in 6 patients: two carriers of a BRCA1 germline mutation, two carriers of TP53 germline mutations (one of which also harbored a BRCA2 deleterious mutation, the other one a BRCA2 unclassified variant), and two carriers of a CDKN2A germline mutation. In addition, 6 variants of unknown signification were identified in BRCA1 or BRCA2 genes. Regarding family history, 3/13 (23%) patients with a positive family history of BC or CMM were carriers of a germline mutation, whereas only 3/69 (4%) patients without family history were carriers of a germline mutation. Conclusion Our findings show that few patients with BC and CMM who lacked family histories of these cancers are carriers of deleterious germline mutations in four of the five genes we examined. We describe for the first time, two simultaneous BRCA2 and TP53 mutations, suggesting that analysis in more than one gene could be performed if a patient's personal or familial history does not match a single syndrome. [less ▲]

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See detailStabilization of Collective Motion in Three Dimensions : A Consensus Approach
Scardovi, Luca; Leonard, Naomi; Sepulchre, Rodolphe ULg

in Proceedings of 46th IEEE Conference on Decision and Control (2007, December)

This paper proposes a methodology to stabilize relative equilibria in a model of identical, steered particles moving in three- dimensional Euclidean space. Exploiting the Lie group structure of the ... [more ▼]

This paper proposes a methodology to stabilize relative equilibria in a model of identical, steered particles moving in three- dimensional Euclidean space. Exploiting the Lie group structure of the resulting dynamical system, the stabilization problem is reduced to a consensus problem on the Lie algebra. The resulting equilibria correspond to parallel, circular and helical formations. We rst derive the stabilizing control laws in the presence of all-to-all communication. Providing each agent with a consensus estimator, we then extend the results to a general setting that allows for unidirectional and time-varying communication topologies. [less ▲]

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See detailLégende de la Carte Numérique des Sols de Wallonie - version 2
Bah, Boubacar Billo; Legrain, Xavier ULg; Engels, Patrick ULg et al

Book published by Unité de Science du Sol - GxABT - ULg - 2ème éd. revue et corrigée (2007)

Cette synthèse commente la structure et le contenu de la légende de la Carte Numérique des Sols de Wallonie (CNSW), réalisée dans le cadre du Projet de Cartographie Numérique des Sols de Wallonie (PCNSW).

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See detailAutonomous rigid body attitude synchronization
Sarlette, Alain ULg; Sepulchre, Rodolphe ULg; Leonard, Naomi

in Proceedings of the 46th IEEE Conference on Decision and Control (2007, December)

This paper studies some extensions to the decentralized attitude synchronization of identical rigid bodies. Considering fully actuated Euler equations, the communication links between the rigid bodies are ... [more ▼]

This paper studies some extensions to the decentralized attitude synchronization of identical rigid bodies. Considering fully actuated Euler equations, the communication links between the rigid bodies are limited and the available information is restricted to relative orientations and angular velocities. In particular, no leader nor external reference dictates the swarm's behavior. The control laws are derived using two classical approaches of nonlinear control - tracking and energy shaping. This leads to a comparison of two corresponding methods which are currently considered for distributed synchronization - consensus and stabilization of mechanical systems with symmetries. [less ▲]

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See detailImplementation and Preliminary Evaluation of an ISP-Driven Informed Path Selection
Saucez, Damien; Donnet, Benoît ULg; Bonaventure, Olivier

in ACM CoNEXT conference (2007, December)

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See detailIntravenous iron therapy restores functional iron deficiency induced by infliximab
Katsanos, Konstantinos; Cavalier, Etienne ULg; Ferrante, Marc et al

in Journal of Crohn’s and Colitis [=JCC] (2007), 1

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See detailInternet Topology Discovery: a Survey
Donnet, Benoît ULg; Friedman, Timur

in IEEE Communications Surveys and Tutorials (2007), 9(4), 2-15

Since the beginning of the nineties, the internet has undergone impres- sive growth. This growth can be appreciated in terms of the equipment, such as routers and links, that has been added, as well as in ... [more ▼]

Since the beginning of the nineties, the internet has undergone impres- sive growth. This growth can be appreciated in terms of the equipment, such as routers and links, that has been added, as well as in the numbers of users and the value of commerce that it supports. In parallel to this expansion, over the past decade the networking research community has shown a growing interest in discovering and analyzing the internet topology. Some researchers have developed tools for gathering network topology data while others have tried to understand and model the internet’s properties. These efforts have brought us to a crucial juncture for toplogy measurement infrastructures: while, previously, these were both small (in terms of number of measurement points) and monolithic, we are starting to see the deployment of large-scale distributed systems composed of hundreds or thousands of monitors. As we look forward to this next generation of systems, we take stock of what has been achieved so far. In this survey, we discuss past and current mechanisms for discovering the internet topology at various levels: the IP interface, the router, the AS, and the PoP level. In addition to discovery techniques, we provide insights into some of the well- known properties of the internet topology. [less ▲]

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See detailLa circonscription fédérale : un placebo administré à un malade incurable?
Bouhon, Frédéric ULg

E-print/Working paper (2007)

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See detailObservations and asteroseismic analysis of the rapidly pulsating hot B subdwarf PG 0911+456
Randall, Suzanna K.; Green, Elizabeth M.; Van Grootel, Valérie ULg et al

in Astronomy and Astrophysics (2007), 476

Aims:The principal aim of this project is to determine the structural parameters of the rapidly pulsating subdwarf B star PG 0911+456 from asteroseismology. Our work forms part of an ongoing programme to ... [more ▼]

Aims:The principal aim of this project is to determine the structural parameters of the rapidly pulsating subdwarf B star PG 0911+456 from asteroseismology. Our work forms part of an ongoing programme to constrain the internal characteristics of hot B subdwarfs with the long-term goal of differentiating between the various formation scenarios proposed for these objects. So far, a detailed asteroseismic interpretation has been carried out for 6 such pulsators, with apparent success. First comparisons with evolutionary theory look promising, however it is clear that more targets are needed for meaningful statistics to be derived. Methods: The observational pulsation periods of PG 0911+456 were extracted from rapid time-series photometry using standard Fourier analysis techniques. Supplemented by spectroscopic estimates of the star's mean atmospheric parameters, they were used as a basis for the “forward modelling” approach in asteroseismology. The latter culminates in the identification of one or more “optimal” models that can accurately reproduce the observed period spectrum. This naturally leads to an identification of the oscillations detected in terms of degree ℓ and radial order k, and infers the structural parameters of the target. Results: The high S/N low- and medium resolution spectroscopy obtained led to a refinement of the atmospheric parameters for PG 0911+456, the derived values being T_eff = 31 940 ± 220 K, log g = 5.767 ± 0.029, and log He/H = -2.548 ± 0.058. From the photometry it was possible to extract 7 independent pulsation periods in the 150-200 s range with amplitudes between 0.05 and 0.8% of the star's mean brightness. There was no indication of fine frequency splitting over the 68-day time baseline, suggesting a very slow rotation rate. An asteroseismic search of parameter space identified several models that matched the observed properties of PG 0911+456 well, one of which was isolated as the “optimal” model on the basis of spectroscopic and mode identification considerations. All the observed pulsations are identified with low-order acoustic modes with degree indices ℓ = 0,1,2 and 4, and match the computed periods with a dispersion of only 0.26%, typical of the asteroseismological studies carried out to date for this type of star. The inferred structural parameters of PG 0911+456 are T_eff = 31 940 ± 220 K (from spectroscopy), log {g} = 5.777 ± 0.002, Mast/Msun = 0.39 ± 0.01, log{M_env/Mast} = -4.69 ± 0.07, R/Rsun = 0.133 ± 0.001 and L/Lsun = 16.4 ± 0.8. We also derive the absolute magnitude MV = 4.82 ± 0.04 and a distance d = 930.3 ± 27.4 pc. [less ▲]

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See detailIntussen aan de kersttafel...
Ozer, Pierre ULg; Perrin, Dominique ULg

Article for general public (2007)

De afgelopen weken heb ik de reclamefolders van mijn dichtstbijzijnde hypermarkt uitgeplozen om een fijn dineetje samen te stellen. Hierna volgt het resultaat voor acht personen, met tussen haakjes het ... [more ▼]

De afgelopen weken heb ik de reclamefolders van mijn dichtstbijzijnde hypermarkt uitgeplozen om een fijn dineetje samen te stellen. Hierna volgt het resultaat voor acht personen, met tussen haakjes het aantal kilometers dat elk ingrediënt heeft afgelegd om naar België te komen en de hoeveelheid CO2 in kilogram die het transport geproduceerd heeft. Ik heb vooral ingrediënten gekozen die met het vliegtuig worden aangevoerd, want luchttransport produceert gemiddeld zestig keer meer CO2 dan vervoer over zee. [less ▲]

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See detailImmobilisation de la lipase de Yarrowia lipolytica.
Alloue, W. A. M.; Destain, Jacqueline ULg; El Mejdoub, Thami ULg et al

Poster (2007, December)

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See detailNoël en famille ou 15 litres de pétrole
Ozer, Pierre ULg; Perrin, Dominique ULg

Article for general public (2007)

La semaine précédant Noël, j’ai décortiqué les publicités de mon hypermarché le plus proche pour préparer le repas familial tant attendu. Et voici ce que j’ai pu concocter pour huit personnes avec, entre ... [more ▼]

La semaine précédant Noël, j’ai décortiqué les publicités de mon hypermarché le plus proche pour préparer le repas familial tant attendu. Et voici ce que j’ai pu concocter pour huit personnes avec, entre parenthèses, les kilomètres parcourus entre le pays de production et la Belgique ainsi que les kilogrammes de CO2 émis uniquement pour le transport aérien intercontinental de ces produits achetés. L’analyse se focalise sur le transport par voie aérienne puisque celui-ci émet, en moyenne, 60 fois plus de CO2 que le transport par voie maritime. [less ▲]

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See detailSport et société. Vers une action de la Fondation Roi Baudouin. Rapport définitif
Cloes, Marc ULg; Vandermeulen, Mary

Report (2007)

En Belgique, la Fondation Roi Baudouin est une référence en matière de développement du bien-être des citoyens. Depuis très longtemps, elle est aussi un des piliers belges en matière du développement d ... [more ▼]

En Belgique, la Fondation Roi Baudouin est une référence en matière de développement du bien-être des citoyens. Depuis très longtemps, elle est aussi un des piliers belges en matière du développement d'activités utilisant les vertus sociales du sport et son rôle pour le bien-être de la population. L'Université de Liège a été chargée de réaliser une étude prospective visant à identifier des pistes d'interventions originales susceptibles de rencontrer les besoins actuels des acteurs de terrain dans le domaine du "sport social" et de stimuler le développement de ce dernier en Communauté Wallonie-Bruxelles. La première étape a porté sur l'établissement d'un état des lieux non exhaustif des initiatives utilisant le sport 'activité physique en général) comme outil social. Sur base des informations fournies par les acteurs de terrain, il était aussi question d'identifier les raisons justifiant le développement limité des nitiatives locales ou régionales dans ce secteur d'activité et les moyens qui devraient être mis en oeuvre pour remédier à cette situation. Dans une deuxième étape, un groupe de praticiens s'est réuni en vue de faire émerger les pistes d'actions dans lesquelles la Fondation Roi Baudouin pourrait s'investir afin de rencontrer les attentes réelles des citoyens. Des propositions concrètes ont ainsi pu être formulées. Elles peuvent être considérées comme des recommandations ou, mieux encore, comme une source d'inspiration. ... [less ▲]

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See detailMolecular Analysis in Two Siblings African Patients with Severe Form of Hunter Syndrome: Identification of a Novel (P.Y54x) Nonsense Mutation
Mutesa, Léon; Muganga, N.; Lissens, Willy et al

in Journal of Tropical Pediatrics (2007), 53(6), 434-7

Hunter syndrome (or Mucopolysaccharidosis type II, MPS II) is an X-linked recessive disorder due to the deficiency of the iduronate-2-sulfatase (IDS) enzyme, resulting in the accumulation of heparan and ... [more ▼]

Hunter syndrome (or Mucopolysaccharidosis type II, MPS II) is an X-linked recessive disorder due to the deficiency of the iduronate-2-sulfatase (IDS) enzyme, resulting in the accumulation of heparan and dermatan sulfates in the lysosomes. The heterogeneity of clinical phenotypes, ranging from mild-to-severe forms, is a result of different mutations in the IDS gene. We report here, a novel nonsense mutation (p.Y54X) in two siblings MPS II African patients affected with a severe form of the disease. We postulated that the p.Y54X mutation which causes a loss of the IDS region highly conserved among sulfatase enzymes, could be predicted as a severe disease-causing mutation for Hunter syndrome. [less ▲]

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See detailEndometrial vessel maturation in women exposed to levonorgestrel-releasing intrauterine system for a short or prolonged period of time
Ravet, Stéphanie ULg; Labied, Soraya ULg; Blacher, Silvia ULg et al

in Human Reproduction (2007), 22(12), 3084-3091

BACKGROUND: Levonorgestrel-releasing intrauterine system (LNG-IUS), although inserted to reduce heavy menstruation, causes irregular early transient bleeding. The objective of the study was to document ... [more ▼]

BACKGROUND: Levonorgestrel-releasing intrauterine system (LNG-IUS), although inserted to reduce heavy menstruation, causes irregular early transient bleeding. The objective of the study was to document quantitative changes in endometrial vessels of short- (< or =3 months) and long-term (> or =12 months) LNG users. The area, density and maturation of endometrial vessels were quantified in 19 endometrial biopsies of women with LNG-IUS and in 10 normally ovulating patients during mid-luteal phase. METHODS: Vessel maturation was evaluated by double immunostaining using anti-von Willebrand factor (endothelial cell marker) and anti-alpha Smooth Muscle Actin (vascular smooth muscle cells) antibodies. Vessel area, number and density were quantified with a novel computer-assisted image analysis system. RESULTS: Endometrium exposed to LNG-IUS for 1-3 months displayed a 11.5-fold increase in small naked vessel number. The partially mature vessel (alphaSMA partially positive) number increased six times. After long-term LNG-IUS treatment, the immature and partially mature vessel number remained four times higher than in the control group. Vessel area and density also increased dramatically in a time-dependent pattern with LNG-IUS use. CONCLUSIONS: Levonorgestrel affects blood vessel number, area, density and maturation in a time-dependent pattern that may explain the early transient increase in breakthrough bleeding with the LNG-IUS. [less ▲]

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See detailApproche territoriale du capital social : recherche qualitative sur un terrain d’application d’une politique visant au redéveloppement d’un quartier par la stimulation du capital social
Italiano, Patrick ULg

Report (2007)

Le rapport analyse, sous l'angle du développement du capital social, une expérience de redéveloppement d'un quartier de Seraing affecté par la désindustrialisation. Il s'appuie sur l'analyse des ... [more ▼]

Le rapport analyse, sous l'angle du développement du capital social, une expérience de redéveloppement d'un quartier de Seraing affecté par la désindustrialisation. Il s'appuie sur l'analyse des dynamiques du travail social, des ressources du quartier, de la participation citoyenne. Il utilise également les résultats d'une enquête menée auprès des habitants du quartier. [less ▲]

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See detailL'image du mois. Un syndrome d' Asherman
Desirotte, Gaëlle ULg; Foidart, Jean-Michel ULg; Nisolle, Michelle ULg

in Revue Médicale de Liège (2007), 62(12), 697-8

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