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See detailGoal-directed Intraoperative therapy reduces morbidity and length of hospital stay in high-risk surgical patients
Donati, A.; Loggi, S.; Preiser, Jean-Charles ULg et al

in Chest (2007), 132(6), 1817-1824

Background: Postoperative organ failures commonly occur after major abdominal surgery, increasing the utilization of resources and costs of care. Tissue hypoxia is a key trigger of organ dysfunction. A ... [more ▼]

Background: Postoperative organ failures commonly occur after major abdominal surgery, increasing the utilization of resources and costs of care. Tissue hypoxia is a key trigger of organ dysfunction. A therapeutic strategy designed to detect and reverse tissue hypoxia, as diagnosed by an increase of oxygen extraction (0,ER) over a predefined threshold, could decrease the incidence of organ failures. The primary aim of this study was to compare the number of patients with postoperative organ failure and length of hospital stay between those randomized to conventional vs a protocolized strategy designed to maintain O2ER < 27%. Methods: A prospective, randomized, controlled trial was performed in nine hospitals in Italy. One hundred thirty-five high-risk patients scheduled for major abdominal surgery were randomized in two groups. All patients were managed to achieve standard goals: mean arterial pressure > 80 mm Hg and urinary output > 0.5 mL/kg/h. The patients of the "protocol group" (group A) were also managed to keep O2ER < 27%. Measurements and main results: In group A, fewer patients had at least one organ failure (n = 8, 11.8%) than in group B (n = 20, 29.8%) [p < 0.05], and the total number of organ failures was lower in group A than in group B (27 failures vs 9 failures, p < 0.001). Length of hospital stay was significantly lower in the protocol group than in the control group (11.3 +/- 3.8 days vs 13.4 +/- 6.1 days, p < 0.05). Hospital mortality was similar in both groups. Conclusions: Early treatment directed to maintain O2ER at < 27% reduces organ failures and hospital stay of high-risk surgical patients. Clinical trials.gov reference No. NCT00254150. [less ▲]

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See detailCaractérisation physiologique et biochimique du processus de vieillissement du tubercule de pomme de terre (Solanum tuberosum L.)
Delaplace, Pierre ULg

Doctoral thesis (2007)

Potato seed tuber is considered as a model organ to study plant ageing. Besides, its physiological age greatly influences germination pattern and thus agronomical performance. In order to unravel the ... [more ▼]

Potato seed tuber is considered as a model organ to study plant ageing. Besides, its physiological age greatly influences germination pattern and thus agronomical performance. In order to unravel the biochemical processes underlying ageing, potato seed tubers (cv. Bintje and Désirée) were stored at 4°C for 7 months and regularly sampled to assess both physiological and biochemical parameters. Physiological age markers (PAI, incubation period) evolution was measured and allowed us to define a reference frame more accurate than the chronological age. A correlation has also been established with the growth parameters (number of stems, duration before emergence). In parallel, two biochemical approaches allowed us to assay proteome and antioxidant system modifications occurring during ageing. Protein pattern evolution was assessed by DIGE after hot SDS extraction. During ageing, 93 spots were strictly up- or down- regulated while 4 others exhibited an abundance curve with a transient maximum. After manual picking of 43 selected spots based on their expression profile, 32 proteins were identified by MS/MS. Differentially expressed proteins are mainly involved in patatin catabolism, stress response, glycolysis, protein turn-over and lipid oxidation. A complementary targeted approach has then been set up based on the free radical ageing theory. SOD, CAT, APX and POX activities as well as ascorbate, glutathione, carotenoid and phenolic compound contents were measured during ageing. These data seem to indicate that the antioxidant system undergoes marked changes in response to an increased production of reactive oxygen species. However, no accumulation of oxidative damages has been observed on lipids and proteins. All these kinetic data allowed us to build an integrated ageing model. These results are discussed in the above-mentioned theoretical context. [less ▲]

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See detailImmobilisation de la lipase de Yarrowia lipolytica.
Alloue, W. A. M.; Destain, Jacqueline ULg; El Mejdoub, Thami ULg et al

Poster (2007, December)

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See detailStabilization of Collective Motion in Three Dimensions : A Consensus Approach
Scardovi, Luca; Leonard, Naomi; Sepulchre, Rodolphe ULg

in Proceedings of 46th IEEE Conference on Decision and Control (2007, December)

This paper proposes a methodology to stabilize relative equilibria in a model of identical, steered particles moving in three- dimensional Euclidean space. Exploiting the Lie group structure of the ... [more ▼]

This paper proposes a methodology to stabilize relative equilibria in a model of identical, steered particles moving in three- dimensional Euclidean space. Exploiting the Lie group structure of the resulting dynamical system, the stabilization problem is reduced to a consensus problem on the Lie algebra. The resulting equilibria correspond to parallel, circular and helical formations. We rst derive the stabilizing control laws in the presence of all-to-all communication. Providing each agent with a consensus estimator, we then extend the results to a general setting that allows for unidirectional and time-varying communication topologies. [less ▲]

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See detailBRCA1, BRCA2, TP53, and CDKN2A germline mutations in patients with breast cancer and cutaneous melanoma
Monnerat, C.; Chompret, A.; Kannengiesser, C. et al

in Familial Cancer (2007), 6(4), 453-461

Purpose From epidemiological studies it appears that breast cancer (BC) and cutaneous melanoma (CMM) in the same individual occur at a higher frequency than expected by chance. Genetic factors common to ... [more ▼]

Purpose From epidemiological studies it appears that breast cancer (BC) and cutaneous melanoma (CMM) in the same individual occur at a higher frequency than expected by chance. Genetic factors common to both cancers can be suspected. Our goal was to estimate the involvement of "high risk" genes in patients presenting these two neoplasia, selected irrespectively from family history and age at diagnosis. Experimental Design Eighty two patients with BC and CMM were screened for BRCA1, BRCA2, TP53, CDKN2A and CDK4 (exon 2) germline mutations. Results Deleterious mutations were identified in 6 patients: two carriers of a BRCA1 germline mutation, two carriers of TP53 germline mutations (one of which also harbored a BRCA2 deleterious mutation, the other one a BRCA2 unclassified variant), and two carriers of a CDKN2A germline mutation. In addition, 6 variants of unknown signification were identified in BRCA1 or BRCA2 genes. Regarding family history, 3/13 (23%) patients with a positive family history of BC or CMM were carriers of a germline mutation, whereas only 3/69 (4%) patients without family history were carriers of a germline mutation. Conclusion Our findings show that few patients with BC and CMM who lacked family histories of these cancers are carriers of deleterious germline mutations in four of the five genes we examined. We describe for the first time, two simultaneous BRCA2 and TP53 mutations, suggesting that analysis in more than one gene could be performed if a patient's personal or familial history does not match a single syndrome. [less ▲]

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See detailAutonomous rigid body attitude synchronization
Sarlette, Alain ULg; Sepulchre, Rodolphe ULg; Leonard, Naomi

in Proceedings of the 46th IEEE Conference on Decision and Control (2007, December)

This paper studies some extensions to the decentralized attitude synchronization of identical rigid bodies. Considering fully actuated Euler equations, the communication links between the rigid bodies are ... [more ▼]

This paper studies some extensions to the decentralized attitude synchronization of identical rigid bodies. Considering fully actuated Euler equations, the communication links between the rigid bodies are limited and the available information is restricted to relative orientations and angular velocities. In particular, no leader nor external reference dictates the swarm's behavior. The control laws are derived using two classical approaches of nonlinear control - tracking and energy shaping. This leads to a comparison of two corresponding methods which are currently considered for distributed synchronization - consensus and stabilization of mechanical systems with symmetries. [less ▲]

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See detailInteraction between dendritic cells and nerve fibres in lymphoid organs after oral scrapie exposure
Dorban, Gauthier ULg; Defaweux, Valérie ULg; Demonceau, Christine ULg et al

in Virchows Archiv (2007), 451(6), 1057-1065

In transmissible spongiform encephalopathies (TSEs), the infectious agent, called PrPsc, an abnormal isoform of the cellular prion protein, accumulates and replicates in lymphoid organs before affecting ... [more ▼]

In transmissible spongiform encephalopathies (TSEs), the infectious agent, called PrPsc, an abnormal isoform of the cellular prion protein, accumulates and replicates in lymphoid organs before affecting the nervous system. To clarify the cellular requirements for the neuro-invasion of the scrapie agent from the lymphoid organs to the central nervous system, we have studied, by confocal microscopy, the innervations within Peyer's patches, mesenteric lymph nodes and the spleen of mice in physiological conditions and after oral exposure to prion. Contacts between nerve fibres and PrPsc-associated cells, dendritic cells (DCs) and follicular dendritic cells (FDCs), were evaluated in preclinical prion-infected mice. Using a double immunolabelling strategy, we demonstrated the lack of innervation of PrPsc-accumulating cells (FDCs). Contacts between nerve fibers and PrPsc-propagating cells (DCs) were detected in T-cell zones and cell-trafficking areas. This supports, for the first time, the possible implication of dendritic cells in the prion neuroinvasion process. [less ▲]

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See detailIntravenous iron therapy restores functional iron deficiency induced by infliximab
Katsanos, Konstantinos; Cavalier, Etienne ULg; Ferrante, Marc et al

in Journal of Crohn’s and Colitis [=JCC] (2007), 1

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See detailLa circonscription fédérale : un placebo administré à un malade incurable?
Bouhon, Frédéric ULg

E-print/Working paper (2007)

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See detailIntussen aan de kersttafel...
Ozer, Pierre ULg; Perrin, Dominique ULg

Article for general public (2007)

De afgelopen weken heb ik de reclamefolders van mijn dichtstbijzijnde hypermarkt uitgeplozen om een fijn dineetje samen te stellen. Hierna volgt het resultaat voor acht personen, met tussen haakjes het ... [more ▼]

De afgelopen weken heb ik de reclamefolders van mijn dichtstbijzijnde hypermarkt uitgeplozen om een fijn dineetje samen te stellen. Hierna volgt het resultaat voor acht personen, met tussen haakjes het aantal kilometers dat elk ingrediënt heeft afgelegd om naar België te komen en de hoeveelheid CO2 in kilogram die het transport geproduceerd heeft. Ik heb vooral ingrediënten gekozen die met het vliegtuig worden aangevoerd, want luchttransport produceert gemiddeld zestig keer meer CO2 dan vervoer over zee. [less ▲]

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See detailOutils pour le diagnostic et la remédiation des difficultés d'acquisition de la lecture en 1re et 2e années du primaire
Deum, Mélanie ULg; Gabelica, Catherine; Lafontaine, Annette ULg et al

Report (2007)

L’apprentissage de la lecture constitue une étape importante pour les enfants; certains d’entre eux l’attendent avec impatience, d’autres le redoutent. La lecture est en effet un processus complexe, on le ... [more ▼]

L’apprentissage de la lecture constitue une étape importante pour les enfants; certains d’entre eux l’attendent avec impatience, d’autres le redoutent. La lecture est en effet un processus complexe, on le sait: l’apprenti lecteur doit apprendre à maîtriser différentes stratégies mais aussi à les coordonner. Les obstacles peuvent donc se situer à différents niveaux et les difficultés peuvent s’ancrer très tôt dans la scolarité, d’autant que les élèves ne sont pas tous égaux lorsqu’ils débutent dans l’apprentissage de la lecture-écriture. Laisser passer l’occasion d’identifier les forces sur lesquelles on pourra s’appuyer, ou les points faibles pour y réagir de manière adéquate dès les étapes initiales de l’apprentissage peut être lourd de conséquences: les difficultés s’accumulent et augurent d’un parcours d’échecs qui peut brouiller les élèves précocement et parfois définitivement avec la lecture, faute d’un diagnostic et d’une remédiation mise en place en temps utile. On connaît toute l’importance de la lecture dans les autres apprentissages scolaires. Même s’il est vrai qu’on apprend à lire toute sa vie, un échec dans les apprentissages de base de la lecture ne se surmonte pas facilement. Or, les outils manquent dans les écoles pour poser un diagnostic fin des difficultés auxquelles certains élèves se heurtent dès leurs premiers pas dans les apprentissages. Les enseignants se sentent démunis face à la réalisation d’un diagnostic précis: ils disent qu’ils peuvent très tôt repérer un élève qui ne suit pas ou n’accroche pas, mais ne savent pas toujours détecter précisément ce qui fait obstacle. Par ailleurs, un sentiment de malaise par rapport à la gestion des difficultés et des différences de niveaux de lecture des élèves a été mis en évidence dans une enquête1 menée auprès d’un échantillon représentatif d’un millier d’enseignants de 1re et 2e années primaires. Très peu d’enseignants estiment être bien préparés pour faire face aux difficultés en lecture et avoir bénéficié d’une formation suffisante en matière de remédiation. Au-delà d’aides plus spécialisées (par l’intervention de logopèdes, par exemple) et du soutien que certains parents peuvent donner à leur enfant, il apparaît essentiel d’apporter une aide aux enseignants responsables de l’apprentissage initial de la lecture. [less ▲]

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See detailNoël en famille ou 15 litres de pétrole
Ozer, Pierre ULg; Perrin, Dominique ULg

Article for general public (2007)

La semaine précédant Noël, j’ai décortiqué les publicités de mon hypermarché le plus proche pour préparer le repas familial tant attendu. Et voici ce que j’ai pu concocter pour huit personnes avec, entre ... [more ▼]

La semaine précédant Noël, j’ai décortiqué les publicités de mon hypermarché le plus proche pour préparer le repas familial tant attendu. Et voici ce que j’ai pu concocter pour huit personnes avec, entre parenthèses, les kilomètres parcourus entre le pays de production et la Belgique ainsi que les kilogrammes de CO2 émis uniquement pour le transport aérien intercontinental de ces produits achetés. L’analyse se focalise sur le transport par voie aérienne puisque celui-ci émet, en moyenne, 60 fois plus de CO2 que le transport par voie maritime. [less ▲]

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See detailApproche territoriale du capital social : recherche qualitative sur un terrain d’application d’une politique visant au redéveloppement d’un quartier par la stimulation du capital social
Italiano, Patrick ULg

Report (2007)

Le rapport analyse, sous l'angle du développement du capital social, une expérience de redéveloppement d'un quartier de Seraing affecté par la désindustrialisation. Il s'appuie sur l'analyse des ... [more ▼]

Le rapport analyse, sous l'angle du développement du capital social, une expérience de redéveloppement d'un quartier de Seraing affecté par la désindustrialisation. Il s'appuie sur l'analyse des dynamiques du travail social, des ressources du quartier, de la participation citoyenne. Il utilise également les résultats d'une enquête menée auprès des habitants du quartier. [less ▲]

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See detailIon Beam Induced Luminescence & Cultural Heritage
Calvo Del Castillo, Helena ULg

Scientific conference (2007, December)

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See detailEndometrial vessel maturation in women exposed to levonorgestrel-releasing intrauterine system for a short or prolonged period of time
Ravet, Stéphanie ULg; Labied, Soraya ULg; Blacher, Silvia ULg et al

in Human Reproduction (2007), 22(12), 3084-3091

BACKGROUND: Levonorgestrel-releasing intrauterine system (LNG-IUS), although inserted to reduce heavy menstruation, causes irregular early transient bleeding. The objective of the study was to document ... [more ▼]

BACKGROUND: Levonorgestrel-releasing intrauterine system (LNG-IUS), although inserted to reduce heavy menstruation, causes irregular early transient bleeding. The objective of the study was to document quantitative changes in endometrial vessels of short- (< or =3 months) and long-term (> or =12 months) LNG users. The area, density and maturation of endometrial vessels were quantified in 19 endometrial biopsies of women with LNG-IUS and in 10 normally ovulating patients during mid-luteal phase. METHODS: Vessel maturation was evaluated by double immunostaining using anti-von Willebrand factor (endothelial cell marker) and anti-alpha Smooth Muscle Actin (vascular smooth muscle cells) antibodies. Vessel area, number and density were quantified with a novel computer-assisted image analysis system. RESULTS: Endometrium exposed to LNG-IUS for 1-3 months displayed a 11.5-fold increase in small naked vessel number. The partially mature vessel (alphaSMA partially positive) number increased six times. After long-term LNG-IUS treatment, the immature and partially mature vessel number remained four times higher than in the control group. Vessel area and density also increased dramatically in a time-dependent pattern with LNG-IUS use. CONCLUSIONS: Levonorgestrel affects blood vessel number, area, density and maturation in a time-dependent pattern that may explain the early transient increase in breakthrough bleeding with the LNG-IUS. [less ▲]

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See detailInternet Topology Discovery: a Survey
Donnet, Benoît ULg; Friedman, Timur

in IEEE Communications Surveys and Tutorials (2007), 9(4), 2-15

Since the beginning of the nineties, the internet has undergone impres- sive growth. This growth can be appreciated in terms of the equipment, such as routers and links, that has been added, as well as in ... [more ▼]

Since the beginning of the nineties, the internet has undergone impres- sive growth. This growth can be appreciated in terms of the equipment, such as routers and links, that has been added, as well as in the numbers of users and the value of commerce that it supports. In parallel to this expansion, over the past decade the networking research community has shown a growing interest in discovering and analyzing the internet topology. Some researchers have developed tools for gathering network topology data while others have tried to understand and model the internet’s properties. These efforts have brought us to a crucial juncture for toplogy measurement infrastructures: while, previously, these were both small (in terms of number of measurement points) and monolithic, we are starting to see the deployment of large-scale distributed systems composed of hundreds or thousands of monitors. As we look forward to this next generation of systems, we take stock of what has been achieved so far. In this survey, we discuss past and current mechanisms for discovering the internet topology at various levels: the IP interface, the router, the AS, and the PoP level. In addition to discovery techniques, we provide insights into some of the well- known properties of the internet topology. [less ▲]

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See detailL'image du mois. Un syndrome d' Asherman
Desirotte, Gaëlle ULg; Foidart, Jean-Michel ULg; Nisolle, Michelle ULg

in Revue Médicale de Liège (2007), 62(12), 697-8

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