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See detailNew Role For Hpar-1 Kinases Emk And C-Tak1 In Regulating Localization And Activity Of Class Iia Histone Deacetylases
Dequiedt, Franck ULg; Martin, Maud ULg; Von Blume, Julia et al

in Molecular and Cellular Biology (2006), 26(19), 7086-102

Class IIa histone deacetylases (HDACs) are found both in the cytoplasm and in the nucleus where they repress genes involved in several major developmental programs. In response to specific signals, the ... [more ▼]

Class IIa histone deacetylases (HDACs) are found both in the cytoplasm and in the nucleus where they repress genes involved in several major developmental programs. In response to specific signals, the repressive activity of class IIa HDACs is neutralized through their phosphorylation on multiple N-terminal serine residues and 14-3-3-mediated nuclear exclusion. Here, we demonstrate that class IIa HDACs are subjected to signal-independent nuclear export that relies on their constitutive phosphorylation. We identify EMK and C-TAK1, two members of the microtubule affinity-regulating kinase (MARK)/Par-1 family, as regulators of this process. We further show that EMK and C-TAK1 phosphorylate class IIa HDACs on one of their multiple 14-3-3 binding sites and alter their subcellular localization and repressive function. Using HDAC7 as a paradigm, we extend these findings by demonstrating that signal-independent phosphorylation of the most N-terminal serine residue by the MARK/Par-1 kinases, i.e., Ser155, is a prerequisite for the phosphorylation of the nearby 14-3-3 site, Ser181. We propose that this multisite hierarchical phosphorylation by a variety of kinases allows for sophisticated regulation of class IIa HDACs function. [less ▲]

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See detailVingt cinq cernes plus tard
Hoffsummer, Patrick ULg; Eeckhout, Jérôme ULg

in Cahiers de l'Urbanisme (Les) (2006), Hors série

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See detailQue peut dire la littérature en Belgique ? Autonomie de la littérature et procès d'écrivains, de Camille Lemonnier à Pierre Mertens
Denis, Benoît ULg

in Durand, Pascal; Hébert, Pierre-Philippe; Mollier, Jean-Yves (Eds.) et al La Censure de l’imprimé. Belgique, France, Québec et Suisse romande. XIXe-XXe siècles (2006)

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See detailEntre égalité des chances et égalité des résultats : l’approche par les capacités d’Amartya Sen
Orianne, Jean-François ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (2006)

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See detailThe Glycosylation of Bovine Pregnancy-Associated Glycoproteins Changes before Parturition
Klisch, K.; Herzog, K.; Feldmann, M. et al

in Reproduction in Domestic Animals (2006)

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See detailPharmacological effects of tiludronate in horses after immobilisation
Delguste, Catherine ULg; Lepage, Olivier M; Doucet, Michèle et al

Poster (2006)

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See detailApproaching field tuned quantum criticality in CeIn3-xSnx
Silhanek, Alejandro ULg; Zocco, D.; Harrison, N. et al

in Physica B: Condensed Matter (2006), 378-80

We report on the magnetic field evolution of the Neel temperature T-N in the heavy electron system CeIn3-xSnx (x = 0 and 0.3), as determined by specific heat, magnetocaloric effect, and electrical ... [more ▼]

We report on the magnetic field evolution of the Neel temperature T-N in the heavy electron system CeIn3-xSnx (x = 0 and 0.3), as determined by specific heat, magnetocaloric effect, and electrical transport measurements. For the stoichiometric compound, T-N is fully suppressed at H-c similar to 65 T, whereas for x = 0.3 the critical field extrapolates to H-c similar to 30 T. An increasing Sommerfeld coefficient gamma, obtained above T-N, as field increases is observed and could be related to the a putative quantum critical point at H-c. (c) 2006 Published by Elsevier B.V. [less ▲]

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See detailContribution à la mission CoRoT et à la recherche d'exoplanètes par la méthode des transits photométriques
Gillon, Michaël ULg

Doctoral thesis (2006)

In this thesis, we present our contributions to the CoRoT mission and to the search for exoplanets with the photometric transit method. We developped a spectroscopic analysis method, APASS, which allows ... [more ▼]

In this thesis, we present our contributions to the CoRoT mission and to the search for exoplanets with the photometric transit method. We developped a spectroscopic analysis method, APASS, which allows to obtain a precise determination of atmospheric physical parameters and abundances for stars with an unnegligeable rotational speed. We present APASS and the high-precision results we obtained for main target stars of the asteroseismological part of the CoRoT mission. Our results are in agreement with those obtained by other authors using different analysis methods, while beeing more precise. Furthermore, they show that the use of a spectroscopic analysis method based on equivalent widths measurements by gaussian or Voigt profiles fitting should be avoided for stars whose rotational velocity is significantly higher then the Sun’s, and that a method using synthetic spectra fitting for which the convolution is a free parameter should be prefered. Next, we investigate the potential of extrasolar planet transit surveys. We show that CoRoT has a very high potential for the detection of close-in giant planets, better than the one of the KEPLER mission. This latter reveals to be better for the detection of terrestrial planets. Nevertheless, CoRoT could detect a few giant telluric planets of short orbital period, provided that this kind of object is frequent in our galaxy. For ground-based surveys, our results based on the use of large telescopes and wide-field cameras seem to indicate that an important potential is also available from the ground. These results are nevertheless less reliable, mainly because of the lack of knowledge about the influence of systematic effects, and additional investigations using actual data will be necessary. We present then the deconvolution method MCS and the way we adapted it to planetary transit photometry. We present the results we obtained after analysis of actual data for OGLE-TR-123 (VLT/FORS2 data) and OGLE-TR-132 (VLT/FORS2 and NTT/SUSI2 data). These results are very encouraging and demonstrate the high potential of MCS for this kind of high-precision analysis. Finally, we present the future improvements we intend to install to obtain a still higher level of precision and to increase the speed of analysis. [less ▲]

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See detailOlympiades mathématiques belges - Recueil de questions - Tome 6 (2003-2006)
Dupont, Pascal ULg

Book published by Société belge des professeurs de mathématique d'expression française (2006)

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See detailHobbes ou le déclin du Royaume des ténèbres. Politique et théologie dans le Léviathan.
Herla, Anne ULg

Book published by Kimé (2006)

Qu'elles soient considérées comme une tentative de légitimation hypocrite ou comme une attestation de foi sincère, les parties III et IV du Léviathan ont souvent été délaissées par les commentateurs. Cet ... [more ▼]

Qu'elles soient considérées comme une tentative de légitimation hypocrite ou comme une attestation de foi sincère, les parties III et IV du Léviathan ont souvent été délaissées par les commentateurs. Cet ouvrage propose de réaffirmer l'importance des ces parties théologiques en leur conférant un sens nouveau. Dépassant l'opposition entre lecture séculière et lecture religieuse, il présente une interprétation de la théorie hobbesienne qui s'attache moins à déterminer les croyances personnelles de Hobbes qu'à déceler les effets pratiques de son discours. Selon l'auteur, c'est un projet politique annonciateur des Lumières qui oriente l'ensemble du Léviathan : émanciper la multitude d'un imaginaire théologico-politique corrompu et des craintes aliénantes qu'il produit. Dans cette perspective, la critique de la superstition et la réforme de l'imaginaire religieux, objet des deux dernières parties du traité, s'avèrent un préalable indispensable à la révolution intellectuelle que constitue la théorie de l'Etat. Dès lors, le Léviathan ne peut plus se voir réduit à une simple théorie de la souveraineté, mais doit aussi être considéré comme un ouvrage de réflexion critique sur l'imaginaire politico-religieux de son époque : il dispense un savoir iconoclaste et émancipateur dont la diffusion est en soi un acte politique. [less ▲]

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See detailBlood vessel changes during pregnancy: a review.
Henry, Frédérique ULg; Quatresooz, Pascale ULg; Valverde-Lopez, Jenny C et al

in American Journal of Clinical Dermatology (2006), 7(1), 65-9

The profound endocrine upheaval of pregnancy is frequently associated with changes in the function and structure of the blood and lymph microvasculature of the skin and mucosae. Palmar erythema is ... [more ▼]

The profound endocrine upheaval of pregnancy is frequently associated with changes in the function and structure of the blood and lymph microvasculature of the skin and mucosae. Palmar erythema is frequent but rarely severe and is associated with burning sensations. Spider telangiectasias develop in the majority of pregnant White women but are less often identified in women with darker skin. Hemangiomas and glomus tumors occur in one-third of women. A firm edema may develop on the face and extremities in the final months of pregnancy. Venous hypertension and varicosities of the lower limbs are common. Gingivitis, gum hypertrophy, and pyogenic granuloma are common in the oral cavity. The vaginal mucosa is also affected, showing a violaceous aspect, at times accompanied by varicosities of the vulva. Many gestational vascular changes regress spontaneously in the postpartum phase. Some vascular tumors may need to be treated with a vascular laser or intense pulsed light. [less ▲]

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See detailPréface (la place des femmes artistes dans l'histoire de l'art)
Bawin, Julie ULg

in catalogue de l’exposition "Elles" (2006)

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See detailStrategy for DR-CALUX dioxin screening in feed under EC regulation
Scippo, Marie-Louise ULg; Rybertt, M. S.; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2006), 68

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See detailAmelioration de la methode d'extraction d'ADN au CTAB appliquee aux feuilles de cotonnier.
Benbouza, H.; Baudoin, Jean-Pierre ULg; Mergeai, Guy ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2006), 10(2), 73-76

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See detailAURA validation by the baloon-borne MkIV Interferometer.
Toon, G. C.; Kleinboehl, A.; Salawitch, R. J. et al

Scientific conference (2006)

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See detailBone Formation around Immediately Loaded Implants: a Bone Chamber Model
Vandamme, K.; Naert, Ignace; Geris, Liesbet ULg et al

in Proceedings of the 84th General Session & Exhibition of the IADR (2006)

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See detailMulti-scale effect of landscape processes and habitat quality on newt abundance: Implications for conservation
Denoël, Mathieu ULg; Lehmann, Anthony

in Biological Conservation (2006), 130(4), 495-504

Recent studies in population dynamics suggest that landscape processes and habitat quality act at different scales on population abundances, but very few have modelled their simultaneous effects. However ... [more ▼]

Recent studies in population dynamics suggest that landscape processes and habitat quality act at different scales on population abundances, but very few have modelled their simultaneous effects. However, at a time of large declines in natural populations, it is essential to understand such multivariate components. We tested the hypothesis that natural populations of palmate newts (Triturus helveticus) are affected on three scales: breeding patch (pond), habitat complementation (terrestrial cover), and metapopulation. structure (density of ponds, surrounding populations). We conducted our survey in 130 ponds from southern France (Larzac) and analysed data with generalized additive models (GAM). Two main novel results emerge from these models: (1) the three landscape scales have significant effects on newt abundance, with more newts in deep, vegetated ponds, devoid of fish and surrounded by wooded areas and inhabited ponds; (2) the quality of the surrounding breeding patches is of primary importance in determining the abundance at core sites in a complex way: high abundances are associated positively with high densities of inhabited ponds, but negatively with the number of surrounding ponds. Deforestation, invasive species and abandonment of ponds all have negative impacts on the persistence of palmate newt populations. Future studies should encompass landscapes at different scales and incorporate the habitat quality in surrounding sites to better understand population dynamics and. provide adequate conservation measures. [less ▲]

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See detailCharacterisation of the magnetic shielding properties of YBaCuO thick films prepared by electrophoretic deposition on silver substrates
Denis, Samuel; Grenci, G.; Dusoulier, Laurent et al

in Journal of Physics: Conference Series (2006), 43

This communication reports experimental results on the superconducting properties of YBaCuO thick films prepared by electrophoretic deposition on silver substrates. The magnetic shielding properties of ... [more ▼]

This communication reports experimental results on the superconducting properties of YBaCuO thick films prepared by electrophoretic deposition on silver substrates. The magnetic shielding properties of the coatings were characterised by various methods. First, the electrical resistance and the transport critical current density, Jc, were determined. Our coatings exhibit a superconducting transition at a temperature of 90 K. Next, shielding characterisations were carried out at 77 K for samples having either a slab or a cylindrical geometry. In both cases, the frequency of the applied magnetic field was 103 Hz; the field behind the shielding wall was measured by a pick-up coil connected to a lock-in amplifier. In the case of cylindrical samples and for an applied induction lower than 1 G, the field inside the shielding enclosure is reduced by a factor greater than 106 (i.e. 120 dB) with respect to the applied field. [less ▲]

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