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See detailNew Role For Hpar-1 Kinases Emk And C-Tak1 In Regulating Localization And Activity Of Class Iia Histone Deacetylases
Dequiedt, Franck ULg; Martin, Maud ULg; Von Blume, Julia et al

in Molecular and Cellular Biology (2006), 26(19), 7086-102

Class IIa histone deacetylases (HDACs) are found both in the cytoplasm and in the nucleus where they repress genes involved in several major developmental programs. In response to specific signals, the ... [more ▼]

Class IIa histone deacetylases (HDACs) are found both in the cytoplasm and in the nucleus where they repress genes involved in several major developmental programs. In response to specific signals, the repressive activity of class IIa HDACs is neutralized through their phosphorylation on multiple N-terminal serine residues and 14-3-3-mediated nuclear exclusion. Here, we demonstrate that class IIa HDACs are subjected to signal-independent nuclear export that relies on their constitutive phosphorylation. We identify EMK and C-TAK1, two members of the microtubule affinity-regulating kinase (MARK)/Par-1 family, as regulators of this process. We further show that EMK and C-TAK1 phosphorylate class IIa HDACs on one of their multiple 14-3-3 binding sites and alter their subcellular localization and repressive function. Using HDAC7 as a paradigm, we extend these findings by demonstrating that signal-independent phosphorylation of the most N-terminal serine residue by the MARK/Par-1 kinases, i.e., Ser155, is a prerequisite for the phosphorylation of the nearby 14-3-3 site, Ser181. We propose that this multisite hierarchical phosphorylation by a variety of kinases allows for sophisticated regulation of class IIa HDACs function. [less ▲]

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See detailÉcritures masculines d’un héroïsme au féminin : portrait moderne d’une mystique médiévale
Henneau, Marie-Elisabeth ULg

in Alémany, Véronique; Cottret, Monique; Cottret, Bernard (Eds.) Saintes ou sorcières? L'héroïsme chrétien au féminin (2006)

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See detailSanté osseuse et ostéoporose: la supplémentation vitamino-calcique en fonction de l’âge
Reginster, Jean-Yves ULg

in Hygiène - Journal de l'Association Française des femmes médecins (2006), 32

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See detailFood safety surveillance through a risk based control programme: Approach employed by the Belgian Federal Agency for the Safety of the Food Chain
Maudoux, J. P.; Saegerman, Claude ULg; Rettigner, C. et al

in Veterinary Quarterly (2006), 28(4), 140-154

The principal responsibility of the Belgian Federal Agency for the Safety of the Food Chain (FASFC) is to guarantee the safety along the food chain. In order to accomplish this responsibility, the FASFC ... [more ▼]

The principal responsibility of the Belgian Federal Agency for the Safety of the Food Chain (FASFC) is to guarantee the safety along the food chain. In order to accomplish this responsibility, the FASFC has developed an integrated official control program to check compliance with various regulations. The original methodology developed and applied by FASFC is presented. This methodology is based on risk evaluation, statistical tools and current scientific knowledge. [less ▲]

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See detailThe use of spatial pattern analysis to support landscape planning and biological conservation.
Bogaert, Jan ULg

in The use of spatial pattern analysis to support landscape planning and biological conservation. Proceedings of the International Conference on Ecological restoration in East Asia, (2006)

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See detailLa traducción entre siglos: un proyecto nacional
Willson, Patricia ULg

in Rubione, Alfredo (Ed.) Historia crítica de la literatura argentina. Volumen 5: La crisis de las formas (2006)

The formal and thematic novelties or peculiarities contributed by foreign literature, their relationship to national literature, the characterization of the importing agents, and the question of language ... [more ▼]

The formal and thematic novelties or peculiarities contributed by foreign literature, their relationship to national literature, the characterization of the importing agents, and the question of language in concrete strategies of translation constitute decisive elements to establish the history of translation in a given culture. In the context of a specific period in the history of Argentine literature, this chapter delves into the origins and shaping of one of the major publishing undertakings of the turn of the century, «La Biblioteca de La Nación», where translation was central and which, according to our hypothesis, was stimulated by the political ideas of the Generation of the Eighties dating back to the 19th century. [less ▲]

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See detailCERA 1892-1998: the force of cooperative solidarity.
Geerkens, Eric ULg

in Revue Belge de Philologie et d'Histoire (2006), 84(4), 1356-1358

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See detailLa ‘preuve cartésienne’ et la voie analytique de Kant
Dubouclez, Olivier ULg

in Fichant, Michel; Marion, Jean-Luc (Eds.) Descartes en Kant (2006)

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See detailAnti-Hemostatic Effects Of A Serpin From The Saliva Of The Tick Ixodes Ricinus
Prevot, Pp.; Adam, B.; Boudjeltia, Kz. et al

in Journal of Biological Chemistry (2006), 281(36), 26361-9

Serpins (serine protease inhibitors) are a large family of structurally related proteins found in a wide variety of organisms, including hematophagous arthropods. Protein analyses revealed that Iris ... [more ▼]

Serpins (serine protease inhibitors) are a large family of structurally related proteins found in a wide variety of organisms, including hematophagous arthropods. Protein analyses revealed that Iris, previously described as an immunomodulator secreted in the tick saliva, is related to the leukocyte elastase inhibitor and possesses serpin motifs, including the reactive center loop (RCL), which is involved in the interaction between serpins and serine proteases. Only serine proteases were inhibited by purified recombinant Iris (rIris), whereas mutants L339A and A332P were found devoid of any protease inhibitory activity. The highest Ka was observed with human leukocyte-elastase, suggesting that elastase-like proteases are the natural targets of Iris. In addition, mutation M340R completely changed both Iris substrate specificity and affinity. This likely identified Met-340 as amino acid P1 in the RCL. The effects of rIris and its mutants were also tested on primary hemostasis, blood clotting, and fibrinolysis. rIris increased platelet adhesion, the contact phase-activated pathway of coagulation, and fibrinolysis times in a dose-dependent manner, whereas rIris mutant L339A affected only platelet adhesion. Taken together, these results indicate that Iris disrupts coagulation and fibrinolysis via the anti-proteolytic RCL domain. One or more other domains could be responsible for primary hemostasis inhibition. To our knowledge, this is the first ectoparasite serpin that interferes with both hemostasis and the immune response. [less ▲]

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See detailA nonlinear time-domain homogenization technique for laminated iron cores in three-dimensional finite-element models
Gyselinck, Johan; V Sabariego, Ruth ULg; Dular, Patrick ULg

in IEEE Transactions on Magnetics (2006), 42(4), 763-766

The authors present a novel nonlinear homogenization technique for laminated iron cores in three-dimensional (3-D) finite-element (FE) models of electromagnetic devices. The technique takes into account ... [more ▼]

The authors present a novel nonlinear homogenization technique for laminated iron cores in three-dimensional (3-D) finite-element (FE) models of electromagnetic devices. The technique takes into account the eddy current effects in the stacked core without the need of modeling all laminations separately. A nonlinear constitutive magnetic law is considered. The system of nonlinear algebraic equations obtained after time discretization is solved by means of the Newton-Raphson scheme. By way of validation, the method is applied to a 3-D FE model of a laminated ring core with toroidal coil. [less ▲]

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See detailAléas climatiques versus actions anthropiques dans le développement des processus de « désertification » sur les marges sud et nord du Sahara
Taibi, Aude Nuscia; El Hannani, Mustapha; Gassani, Jean et al

in Interactions Nature-Société, analyses et modèles (2006)

Les marges sud et nord du Sahara sont soumises à des processus de dégradation anciens attestés par de nombreux travaux de terrain. Ils coïncident avec l'occurrence d'une sécheresse sévère sur les 3 sites ... [more ▼]

Les marges sud et nord du Sahara sont soumises à des processus de dégradation anciens attestés par de nombreux travaux de terrain. Ils coïncident avec l'occurrence d'une sécheresse sévère sur les 3 sites d'étude, débutée dans les années 1970 en Algérie (piémont sud de l'Atlas Saharien), au Maroc (bassin de l'oued Dadès) et en Mauritanie (lac d'Aleg, Brakna). Les suivis diachroniques par télédétection satellitaire (Landsat et SPOT) et aérienne (1954 à 2002) et des observations récentes, montrent la pérennité voire l'extension de certaines zones de dégradation localisées à proximité des agglomérations et points d'eau, malgré le retour des précipitations. Le rythme et les modalités de développement des dynamiques en œuvre, qui prennent la forme d'une dégradation qualitative et quantitative des couverts végétaux steppiques et de savane ainsi qu'une revivification des dunes d'Aleg, attestent du rôle prépondérant de certains activités humaines dans les processus de dégradation de ces milieux, en corrélation avec la crise climatique dont on peut se demander si elle n'est pas devenue un facteur secondaire. Sans ignorer les enjeux socio-économiques de développement, notre démarche vise à comprendre les logiques d'action des dynamiques complexes parfois abusivement désignées sous le terme simplificateur de «désertification». [less ▲]

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See detailIn situ sampling of pore waters from seagrass meadows
Gobert, Sylvie ULg; Lepoint, Gilles ULg; Biondo, Renzo ULg et al

in Biologia Marina Mediterranea (2006), 13

A routine and low cost method to collect pore water in a seagrass meadow in situ and underwater is here proposed. The method consists of direct-suction filtered sampling allowing the determination of ... [more ▼]

A routine and low cost method to collect pore water in a seagrass meadow in situ and underwater is here proposed. The method consists of direct-suction filtered sampling allowing the determination of nutrient concentrations in the sampled water. Data ranges of nutrient (NO2-+NO3-; HPO4 2- and NH4+) concentrations in a P. oceanica meadow are also discussed [less ▲]

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See detailThe Belgian Contribution
Noels-Grötsch, Arlette ULg; Aerts, Conny; Plesseria, Jean-Yves ULg et al

in Fridlund, M.; Baglin, A.; Lochard, J. (Eds.) et al Proceedings of "The CoRoT Mission Pre-Launch Status - Stellar Seismology and Planet Finding" (2006)

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See detailDétection des bifidobactéries dans le lait cru
Delcenserie, Véronique ULg

Scientific conference (2006)

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See detailL'effondrement de la Générale des Carrières et des Mines.Chronique d'un processus de privatisation informelle
Rubbers, Benjamin ULg

in Cahiers d'Etudes Africaines (2006), 181

How this mining giant abruptly collapsed is the focus of this article. Instead of adopting what has become a classic interpretation-Mobutu's patrimonial politics and a poor economic environment, this work ... [more ▼]

How this mining giant abruptly collapsed is the focus of this article. Instead of adopting what has become a classic interpretation-Mobutu's patrimonial politics and a poor economic environment, this work underscores the internal dynamics of the company, in its particular social setting. [less ▲]

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See detailInter- and intra-guild interactions related to aphids in nettle (Urtica dioica L.) strips closed to field crops.
Alhmedi, A.; Haubruge, Eric ULg; Bodson, Bernard ULg et al

in Communications in Agricultural and Applied Biological Sciences (2006), 71(2 Pt B), 413-23

A field experiment designed to assess the biodiversity related to nettle strips closed to crops, and more particularly the aphid and related beneficial populations, was established in experimental farm ... [more ▼]

A field experiment designed to assess the biodiversity related to nettle strips closed to crops, and more particularly the aphid and related beneficial populations, was established in experimental farm located in Gembloux (Belgium). Margin strips of nettle (Urtica dioica) closed to wheat (Triticum aestivum), green pea (Pisum sativum) and rape (Brassicae napus) fields were investigated. The diversity, abundance of aphids and related predators were analysed according to the plant crop species and the differential pesticide application (treated plot and control). Insects were visually observed every week during all the cultivation season. Two main families of aphidophagous predators were found in all field crops and nettle, the Coccinellidae and Syrphidae. The diversity of the aphidophagous predators was shown to be higher on nettle than in field crops, particularly the Chrysopidae, the Anthocoridae and the Miridae. However, a striking difference of ladybird abundance was observed according to the aphid host plant. In one side, Coccinella septempunctata was much more abundant on Acyrthosiphon pisum infested green pea than on the other host plant species. At the opposite, higher occurrence of Harmonia axyridis was observed on the aphid infested nettle plants than on the crop plants. In particular, none of H. axyridis was found in wheat crop. Also, more than only a significant positive correlation between predator and aphid abundance, specialised relations between particular aphid species and some so-called generalist predators was determined in the fields. Finally, intraguild interactions between the aphidophagous predators was assessed and shown that only a significant negative correlation between Episyrphus balteatus and H. axyridis related to the nettle aphid, Micrlophium carnosum, was observed. The relative distribution of the ladybirds, namely C. septempunctata and H. axyridis according to the host plant, nettle strips and crop plots was discussed in relation to integrated pest management approach. [less ▲]

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See detailGlaciaçoes neodevonianas E Eocarboniferas na America do sul.
Caputo, M.V.; Streel, Maurice ULg; Melo, H.G. et al

in Simposio da Amazonias (2006)

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