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See detailExercise and pharmacological stress echocardiography in healthy horses
Sandersen, Charlotte ULg; Detilleux, Johann ULg; Art, Tatiana ULg et al

in Equine Veterinary Journal. Supplement (2006), 37

REASONS FOR PERFORMING STUDY: Stress echocardiography could be a useful diagnostic test in horses suspected to suffer from exercise-induced myocardial dysfunction as a cause of exercise intolerance ... [more ▼]

REASONS FOR PERFORMING STUDY: Stress echocardiography could be a useful diagnostic test in horses suspected to suffer from exercise-induced myocardial dysfunction as a cause of exercise intolerance. OBJECTIVE: To evaluate the effect of treadmill exercise and pharmacological stress test on left ventricular echocardiographic parameters. METHODS: Echocardiography was performed in 2 groups of 5 healthy horses, either immediately after a near-maximal treadmill exercise (Group EXE) or during a pharmacological challenge (Group DOB) consisting of 35 microg/kg atropine, followed by incremental dobutamine infusion rates of 2-6 microg/kg bwt/min for 5 min duration each, which led to a cumulative dobutamine dose of 100 microg/kg. Left ventricular M-mode parameters were compared at rest and at heart rates of 80, 100, 110, 120 130, and 140 beats/min, within each group. RESULTS: In 2 horses of Group EXE, echocardiographic measurements were impossible at 140 and 130 beats/min, as their heart rates dropped too fast in the immediate post exercise period. In the remaining 3 horses image quality was not always satisfactory at heart rates of 130 and 140 beats/min. Systolic left ventricular parameters and fractional shortening measured at 130 and 140 beats/min were significantly different from values obtained at lower heart rates. Horses in Group DOB reached expected heart rates of 80 and 100 beats/min, after the administration of atropine and during a dobutamine infusion rate of 2 microg/kg bwt/min, respectively. Heart rates targets of 110, 120, 130, and 140 beats/min were reached at mean (+/- s.d.) dobutamine infusion rates of 2.8 +/- 0.4, 3.2 +/- 0.4, 4.0 +/- 0.7, 5 +/- 0.7 microg/kg bwt/min, respectively. Systolic left ventricular parameters and fractional shortening at heart rates of 110, 120, 130, and 140 beats/min, were significantly different from values obtained at lower heart rates. CONCLUSION: The pharmacological stress test induced changes in ventricular dimensions at heart rates of 80 to 140 beats/min. Using this test, high quality images can easily be obtained at heart rates of 140 beats/min. Conversely, in post exercise echocardiography, obtaining good quality images at heart rates of 130 and 140 beats/min is difficult, which limits use of the technique in routine clinical settings. POTENTIAL RELEVANCE: Further studies should demonstrate the potential of pharmacological stress test as a diagnostic tool in horses suffering from exercise-induced myocardial dysfunction. [less ▲]

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See detailFrom the design to the clinical application of thromboxane modulators
Dogné, Jean-Michel ULg; Hanson, Julien ULg; de Leval, Xavier et al

in Current Pharmaceutical Design (2006), 12(8), 903-923

Arachidonic acid (AA) metabolites are key mediators involved in the pathogenesis of numerous cardiovascular, pulmonary, inflammatory, and thromboembolic diseases. One of these bioactive metabolites of ... [more ▼]

Arachidonic acid (AA) metabolites are key mediators involved in the pathogenesis of numerous cardiovascular, pulmonary, inflammatory, and thromboembolic diseases. One of these bioactive metabolites of particular importance is thromboxane A(2) (TXA(2)). It is produced by the action of thromboxane synthase on the prostaglandin endoperoxide H-2 (PGH(2)) which results from the enzymatic transformation of AA by the cyclooxygenases. It is a potent inducer of platelet aggregation, vasoconstriction and bronchoconstriction, and has been involved in a series of major pathophysiological conditions. Therefore, TXA(2) receptor antagonists, thromboxane synthase inhibitors and drugs combining both properties have been developed by different laboratories since the early 1980s. Several Compounds have been launched on the market and others are tinder clinical evaluation. In the first part of this review. we will describe the physiological properties of TXA(2), thromboxane synthase and thromboxane receptors. The second part is dedicated to a description of each class of thromboxane modulators with the advantages and disadvantages they offer. In the third part. we aim to describe recent studies performed with the most interesting thromboxane modulators in major pathologies: myocardial infarction and thrombosis, atherosclerosis, diabetes, pulmonary embolism, septic shock.. preeclampsia, and asthma. Each pathology will be systematically reviewed. Finally, in the last part we will highlight the latest perspectives in drug design of thromboxane modulators and in their future therapeutic applications such as cancer, metastasis and angiogenesis. [less ▲]

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See detailA scale transition procedure for flexural effects
Mercatoris, Benoît ULg; Massart, Thierry J.

in 7th National Congress on Theoretical and Applied Mechanics (NCTAM2006) (2006)

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See detailQuand une lettre erronée de la banque libère l'emprunteur, note sous J.P. Anvers, 1e avril 2003
Crabeels, Fanny ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (2006)

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See detailElasto-plastic material parameter identification by inverse methods: sensitivity matrix calculation
Cooreman, Steven; Bouffioux, Chantal ULg; Lecompte, David et al

in Proceedings of the SEM annual conference and exposition 2006 (2006)

Inverse methods offer a powerful tool for the determination of the elasto-plastic material properties. Contrary to standard tests, these methods can deal with heterogeneous stress and strain-fields which ... [more ▼]

Inverse methods offer a powerful tool for the determination of the elasto-plastic material properties. Contrary to standard tests, these methods can deal with heterogeneous stress and strain-fields which have a larger information contents and hence allow the simultaneous identification of several material parameters. Moreover, it is expected that the obtained material parameters are more accurate, since these heterogeneous deformation fields are much closer to those occurring in real (metal) forming operations. The principle of the inverse method for the identification of material parameters presented in this paper is to compare an experimentally measured strain field to that computed by a Finite Element (FE) model. The material parameters in the FE model are iteratively tuned in such a way that both strain fields match each other as close as possible. One of the building blocks in this identification procedure is the updating algorithm for the material parameters in the FE model. The key problem of this updating algorithm is the determination of the sensitivity matrix, which expresses the sensitivities of the strains with respect to the material parameters. This paper presents an analytical method for the calculation of this sensitivity matrix in case of simple tensile tests. [less ▲]

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See detailInvestigation of blood oxidant/antioxidant markers in healthy competition horses : effect of discipline and gender.
Kirschvink, N.; De Moffarts, Brieuc; Farnir, Frédéric ULg et al

in 7th International Conference on Equine Exercise Physiology (2006)

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See detailConservation des ressources génétiques animales en Région wallonne: le paradoxe de l'hyperspécialisation
Daniaux, Christel ULg; Stassart, Pierre M ULg; Massart, Serges et al

in 13éme journées "3R" Proceeding (2006)

The main breed of the waloon regio are adapted to conditions of intensive production with extrem phenotypic experssion.

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See detailLes codes La Charte, Droit social
Clesse, Jacques ULg; Kefer, Fabienne ULg

Book (2006)

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See detailTable ronde : "Le Normal et le Pathologique"
Fournier, Emmanuel; Jabre, JF; Labarre-Vila, Annick et al

in Neurophysiologie Clinique = Clinical Neurophysiology (2006)

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See detailLe statut externe du détenu
Jacobs, Ann ULg

in Actualités de droit pénal et de procédure pénale (2006)

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See detailKeeping track of the EEG's brain dynamics using Kalman filtering
Lehembre, Remy ULg; Noirhomme, Quentin ULg; Macq, B.

in Proceedings of the 3rd International BCI Workshop (2006)

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See detailBecoming a father: a clinical investigation of the construction of the new identity by first-time fathers
Naziri, Despina ULg; De Coster, L.; De Gheest, F.

in Majerus, Steve; Laroi, Frank; Hansenne, Michel (Eds.) et al Proceedings of the annual meeting of the Belgian Psychological Society (2006)

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See detailRelating Cross Gramians and Sensitivity Analysis in Systems Biology
Streif, S.; Findeisen, R.; Bullinger, Eric ULg

in Proceedings of the 17th International Symposium on Mathematical Theory of Networks and Systems (MTNS 2006) (2006)

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See detailCompte-rendu de l'ouvrage de Harry Van Velthoven: « Zwerver in Niemandsland ». Julius Hoste en zijn Londens oorlogsdagboek
Lanneau, Catherine ULg

in Bulletin d'Information de l'Association Belge d'Histoire Contemporaine = Mededelingenblad van de Belgische Vereniging voor Nieuwste Geschiedenis (2006), XXVIII(2), 50-52

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See detailPharmacological Treatment of Ambulatory Schizophrenic Patients in Belgium
Hanssens, L.; De Hert, M.; Wampers, M. et al

in Clinical Practice and Epidemiology in Mental Health (2006), 2

BACKGROUND: the objective of this study was twofold:1) Describe the use of antipsychotic treatments in ambulatory patients suffering from schizophrenia in Belgium.2) Evaluate to which extend antipsychotic ... [more ▼]

BACKGROUND: the objective of this study was twofold:1) Describe the use of antipsychotic treatments in ambulatory patients suffering from schizophrenia in Belgium.2) Evaluate to which extend antipsychotic treatment prescribing patterns are in accordance with published treatment guidelines. METHOD: A cross-sectional survey was carried out in 16 Belgian hospitals selected from a sample of 67 hospitals. The hospitals were equally distributed between the north and south part of the country and were representative of Belgian practice. During 2 months, participating psychiatrists were asked to record the medication use as well as demographic parameters of all consecutive ambulatory patients seen at their consultation or attending a day-hospital. Data concerning 1000 ambulatory patients with schizophrenia or schizoaffective disorder were collected. RESULTS: In Belgium, the use of atypical antipsychotics is frequent (69%) in ambulatory patients with schizophrenia. In the overall sample, 73% receive only one antipsychotic drug. The majority of patients are treated with drugs of only one antipsychotic drug group, either first- typical (29.8%) or second-generation, atypical antipsychotics (53.2%). 15.8% of patients combine different types of antipsychotics. Antipsychotic dosing is adequate for the majority of patients but about one fifth receives a higher than recommended dose as per package inserts. Polypharmacy remains within reasonable limits. The use of concomitant medication varies according the antipsychotic treatment: patients who take second-generation antipsychotics only, receive the least additional drugs. CONCLUSION: Atypical antipsychotics appear to be the first line treatment for schizophrenic psychosis. Psychiatrists working with ambulatory patients are well aware of treatment guidelines and follow them quite adequately. [less ▲]

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See detailPalyWeb
Steemans, Philippe ULg; Breuer, P.

Conference (2006)

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