References of "2006"
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See detailp27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex.
Nguyen, Laurent ULg; Besson, Arnaud; Heng, Julian Ik-Tsen et al

in Genes & Development (2006), 20(11), 1511-24

The generation of neurons by progenitor cells involves the tight coordination of multiple cellular activities, including cell cycle exit, initiation of neuronal differentiation, and cell migration. The ... [more ▼]

The generation of neurons by progenitor cells involves the tight coordination of multiple cellular activities, including cell cycle exit, initiation of neuronal differentiation, and cell migration. The mechanisms that integrate these different events into a coherent developmental program are not well understood. Here we show that the cyclin-dependent kinase inhibitor p27(Kip1) plays an important role in neurogenesis in the mouse cerebral cortex by promoting the differentiation and radial migration of cortical projection neurons. Importantly, these two functions of p27(Kip1) involve distinct activities, which are independent of its role in cell cycle regulation. p27(Kip1) promotes neuronal differentiation by stabilizing Neurogenin2 protein, an activity carried by the N-terminal half of the protein. p27(Kip1) promotes neuronal migration by blocking RhoA signaling, an activity that resides in its C-terminal half. Thus, p27(Kip1) plays a key role in cortical development, acting as a modular protein that independently regulates and couples multiple cellular pathways contributing to neurogenesis. [less ▲]

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See detailAdvanced exploitation of ground-based Fourier transform infrared observations for tropospheric studies over Europe: achievements of the UFTIR project
De Mazière, Martine; Vigouroux, Corinne; Blumenstock, Thomas et al

in Geophysical Research Abstracts (2006), 8

Solar absorption measurements using Fourier transform infrared (FTIR) spectrometry carry information about the atmospheric abundances of many constituents, including information about their vertical ... [more ▼]

Solar absorption measurements using Fourier transform infrared (FTIR) spectrometry carry information about the atmospheric abundances of many constituents, including information about their vertical distributions in the troposphere and the stratosphere. Such observations have regularly been made since many years as a contribution to the NDSC (Network for the Detection of Stratospheric Change). They are the only ground-based remote sensing observations available nowadays that carry information about key atmospheric trace species in the free troposphere, among which the most important greenhouse gases. The European UFTIR project (Time series of Upper Free Troposphere observations from a European ground-based FTIR network, http://www.nilu.no/uftir) has focused on maximizing the information content of FTIR long-term monitoring data of some direct and indirect greenhouse gases (CH4, N2O, O3,HCFC-22, and CO and C2H6, respectively). The UFTIR network includes six NDSC stations in Western Europe, covering the polar to subtropical regions. At several stations of the network, the observations span more than a decade. Existing spectral time series have been reanalyzed according to a common optimized retrieval strategy, in order to derive distinct tropospheric and stratospheric abundances of the abovementioned target gases. A bootstrap resampling method has been implemented to evaluate trends of the tropospheric and total burdens of the target gases, including their uncertainties. In parallel, simulations of the target time series have been made with the Oslo CTM2 model: comparisons between the model results and the observations provide valuable information to improve the model, and in particular, to optimize emission estimates that are used as inputs to the model simulations, and to explain the observed trends. The final results of the project will be presented, and ways to proceed will be discussed. [less ▲]

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See detailL'Amérique latine: champs favorables pour le renforcement de l'identité extérieure de l'Union européenne?
Santander, Sébastian ULg

in Aparicio, Miriam (Ed.) L'identité en Europe et sa trace dans le monde (2006)

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See detailFour-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity
Cruyssen, B. V.; Van Looy, S.; Wyns, B. et al

in Arthritis Research & Therapy (2006), 8(4), 112

Although there is strong evidence supporting the short-term efficacy and safety of anti-tumour necrosis factor-alpha agents, few studies have examined the long-term effects. We evaluated 511 patients with ... [more ▼]

Although there is strong evidence supporting the short-term efficacy and safety of anti-tumour necrosis factor-alpha agents, few studies have examined the long-term effects. We evaluated 511 patients with long-standing refractory rheumatoid arthritis treated with intravenous infusions of infliximab 3 mg/kg at weeks 0, 2, 6, and 14 and every 8 weeks thereafter for 4 years. Among the initial 511 patients included in the study, 479 could be evaluated; of these, 295 (61.6%) were still receiving infliximab treatment at year 4 of follow-up. The most common reasons for treatment discontinuation were lack of efficacy (65 patients, 13.6%), safety (81 patients, 16.9%), and elective change (38 patients, 7.9%). Analysis of disease activity scores (DAS28 [ disease activity score based on the 28-joint count]) over time showed that, after the initial rapid improvement during the first 6 to 22 weeks of therapy, a further decrease in disease activity of 0.2 units in the DAS28 score per year was observed. DAS28 scores, measured at week 14 or 22, were found to predict subsequent discontinuation due to lack of efficacy. In conclusion, long-term maintenance therapy with infliximab 3 mg/kg is effective in producing further reductions in disease activity. Disease activity measured by the DAS28 at week 14 or 22 of infliximab therapy was the best predictor of long-term attrition. [less ▲]

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See detailGeht es noch kleiner?
Pfennig, Andreas ULg

in Miniplant-Technik: in der Prozessindustrie (2006)

See detailArmoede bij personen van vreemde herkomst becijferd
Van Robaeys, Bea; Perrin, Nathalie ULg

Report (2006)

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See detailDe prosodie-syntaxis interface in contrastief perspectief
Rasier, Laurent ULg

Conference (2006)

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See detailAutour d’une ingénierie lakatosienne de la notion de limite
Job, Pierre ULg

Scientific conference (2006)

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See detailFaut-il brûler la gestion des compétences? Une exploration des pratiques en entreprise
Pichault, François ULg; Antoine, Mélanie ULg; Deflandre, Dimitri ULg et al

Book published by De Boeck (2006)

Ouvrage - Après plus d'une décennie de discours promotionnels sur la gestion des compétences, censée renouveler le mode de fonctionnement des organisations, l'ouvrage entend lever le voile sur les ... [more ▼]

Ouvrage - Après plus d'une décennie de discours promotionnels sur la gestion des compétences, censée renouveler le mode de fonctionnement des organisations, l'ouvrage entend lever le voile sur les pratiques que l'on peut observer en la matière. Dans quelle mesure la gestion des compétences contribue-t-elle à modifier effectivement la relation de travail ? Peut-on vraiment y voir l'esquisse d'un nouveau mode de gouvernance des organisations contemporaines ? Ou faut-il au contraire la brûler sur le même bûcher que d'autres modes managériales ? A partir de l'exposé détaillé de quatre cas relevant à la fois de l'industrie et des services, l'ouvrage aboutit à montrer que la gestion des compétences peut prendre des formes concrètes très diverses. En s'écartant d'une certaine image d'Epinal véhiculée par la littérature gestionnaire, les auteurs proposent une typologie de situations parfois surprenantes qui établit l'influence prépondérante des contextes d'émergence et du processus d'introduction de la gestion des compétences. L'ouvrage s'adresse aux chercheurs, formateurs et étudiants de 2e et 3e cycles en gestion, en économie et en sociologie, désireux de découvrir la gestion des compétences par le prisme d'études de cas en entreprise et de se familiariser avec la façon dont la gestion des démarches compétences est mise en oeuvre dans les entreprises. [less ▲]

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See detailEtude des disparités de la chirurgie élective en Belgique
Jacques, Jessica ULg; Gillain, Daniel ULg; Fecher-Bourgeois, Fabienne ULg et al

Report (2006)

La chirurgie élective recouvre les interventions qui peuvent normalement être programmées calmement sans danger immédiat pour la santé du patient. Naïvement, on pourrait s’attendre à ce que cette ... [more ▼]

La chirurgie élective recouvre les interventions qui peuvent normalement être programmées calmement sans danger immédiat pour la santé du patient. Naïvement, on pourrait s’attendre à ce que cette caractéristique contribue à des décisions d’intervention mûrement réfléchies et donc à peu de disparités entre les pratiques. Et pourtant on découvre dans la littérature internationale que le lieu de résidence du patient influence nettement la probabilité de subir certaines interventions. Ces différences sont-elles aussi observées en Belgique ? Quelle intervention, de la cataracte, du syndrome du canal carpien ou de la sténose carotidienne, présente la plus grande variabilité ? Où fait-on le plus d’arthroscopies en Belgique ? La prothèse totale de hanche et la prothèse totale de genou sont-elles liées géographiquement ? Et qu’en est-il de la césarienne, dont on a encore récemment beaucoup entendu parler dans l’actualité, pour la proportion inquiétante de césariennes dans certains hôpitaux ? Illustrer simplement les différences de pratique ne suffit pas. Classiquement, il s’agit ensuite d’essayer d’éliminer l’effet de plusieurs variables qui pourraient objectivement expliquer les différences observées, comme des comorbidités, des variables socioéconomiques, des facteurs d’offre médicale, … Mais les disparités de pratique subsistent en Belgique même après avoir éliminé l’effet de ces variables. Ceci avait déjà été mis en évidence dans des études précédentes. On débouche alors inévitablement sur un questionnement à propos de l’opportunité des soins. Cette recherche démontre que pour certaines interventions, il est possible de mettre en évidence une association entre « trop de soins donnés » et des « soins médicalement inopportuns ». Mais ce n’est pas toujours le cas, le questionnement reste alors entier et l’instauration de mesures qui viseraient à diminuer des différences non justifiées reste à l’ordre du jour. Une collaboration de fond avec les acteurs de terrain pour chaque domaine spécifique est un « must », comme le prouve cette étude. En outre, cette étude a montré une fois de plus que la Belgique est riche en bases de données qui ne demandent qu’à être exploitées, pas seulement par le KCE mais aussi par tous les autres acteurs qui cherchent à utiliser le plus efficacement possible les moyens disponibles pour offrir à tous les patients les meilleurs soins. [less ▲]

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See detailLa ‘preuve cartésienne’ et la voie analytique de Kant
Dubouclez, Olivier ULg

in Fichant, Michel; Marion, Jean-Luc (Eds.) Descartes en Kant (2006)

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See detailDetermination of solid fat content (SFC) of binary fat blends and use of these data to predict SFC of selected ternary fat blends containing low-erucic rapeseed oil
Danthine, Sabine ULg; Deroanne, Claude ULg

in Journal of the American Oil Chemists' Society (2006), 83(7), 571-581

Several oils and fats often used for the industrial preparation of European shortenings were blended in binary systems. The equilibrium (after 48 h at 15 degrees C) solid fat contents (SFC; determined by ... [more ▼]

Several oils and fats often used for the industrial preparation of European shortenings were blended in binary systems. The equilibrium (after 48 h at 15 degrees C) solid fat contents (SFC; determined by pulsed NMR spectroscopy) were measured and plotted against blend composition. SFC of the blends resulted from the SFC of each fat for the considered temperature as well as the type of interaction existing between those fats (namely, ideal behavior, monotectic interaction, eutectic interaction, and so on). The type of relationship fitted was dependent on the kind of interaction: Linear relationships were found for total compatibility between fats, and polynomial-type (order 2) relationships were found for fats exhibiting incompatibility. Some corresponding ternary oils and fats blends were also prepared and analyzed. Selected relationships (regression equations of the fitted curves) obtained for binary blends were combined in order to calculate the SFC of the corresponding ternary blends. Experimental values were generally close to predicted ones. The representation of SFC as a function of composition is interesting as it allows one to determine rapidly and easily the type of molecular interaction between two fats and also to determine equations that can be. combined to calculate easily the SFC of corresponding ternary blends crystallized in the same way with a good accuracy. The texture (hardness) of several binary and ternary blends was also measured. The combination of the results obtained for SFC with the results obtained for the hardness of binary blends allows the prediction of the hardness of a corresponding ternary blend under the same conditions. [less ▲]

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See detailNumerical modeling of the hydro-mechanical behaviour of a large slope movement: the Triesenberg landslide
François, Bertrand ULg; Bonnard, Christophe; Laloui, Lyesse et al

in Zimmermann, T.; Truty, A. (Eds.) Numerics in geotechnics and structures (2006)

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See detailLa chronologie de Biryuchya Balka (Région de Rostov, Russie)
Otte, Marcel ULg; Matyukhin, Alexander; Flas, Damien ULg

in Rannyaya pora verkhnego Paleolita evrazii: obtcheié i lokalnoié (2006)

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See detailIntegration of longevity into the Walloon genetic evaluation system
Vanderick, Sylvie ULg; Croquet, Coraline; Soyeurt, Hélène ULg et al

in Interbull Bulletin (2006), 35

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See detailL'entretien d'aide en situation de souffrance relationnelle au travail
Faulx, Daniel ULg

Report (2006)

Ce chapitre aborde les différentes manières de mener des entretiens avec des personnes vivant une situation de harcèlement ou de conflit.

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See detailLa mammite bovine : de l’initiation à la résolution
Boutet, Philippe ULg; Bureau, Fabrice ULg; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (2006), 150(1), 1-26

The bovine mastitis : from initiation to resolution The cure of a cow suffering from a bacterial mastitis relies on the balance between the eradication of the pathogen and the resolution of the ... [more ▼]

The bovine mastitis : from initiation to resolution The cure of a cow suffering from a bacterial mastitis relies on the balance between the eradication of the pathogen and the resolution of the inflammatory response, two processes that are essential to come back to a normal milk composition with low somatic cell count. The persistence of the inflammatory response, which main consequence is a reduction in milk yield, is a feature of chronic mastitis. This frequent disease depends on inappropriate host-pathogen interactions and is not yet well understood. This review resumes the main defence mechanisms of the bovine mammary gland, emphasizing the predominant roles played by the neutrophil, and brings some precisions on lipoxin implications in the resolution of inflammation. Reasons that may explain the persistence of the inflammatory reaction, a phenomenon found in the Staphylococcus aureus chronic mastitis, are also discussed. [less ▲]

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