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See detailEtude de la diversité génétique de l'ulluco (Ullucus tuberosus Loz.) en conservation ex situ
Malice, Marie ULg; Villaroel Vogt, C. L.; Rochez, G. et al

Conference given outside the academic context (2006)

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See detailNifedipine nanocrystals: pharmacokinetic evaluation in the rat and permeability studies in Caco-2/HT29-5M21 (co)-cultures
Hecq, Julien; Nollevaux, Géraldine; Deleers, M. et al

in Journal of Drug Delivery Science and Technology (2006), 16(6, NOV-DEC), 437-442

Poorly water-soluble drugs such as nifedipine (NIF) (similar to 20 mu g/mL) offer challenging problems in drug formulation as poor solubility is generally associated with poor dissolution characteristics ... [more ▼]

Poorly water-soluble drugs such as nifedipine (NIF) (similar to 20 mu g/mL) offer challenging problems in drug formulation as poor solubility is generally associated with poor dissolution characteristics and thus with poor oral bioavailability (BCS class H drugs). In order to enhance these characteristics, formulation of NIF as nanocrystals was carried out. NIF nanoparticles (NP) were prepared using high-pressure homogenization (HPH). Solubility and dissolution characteristics have been reported in previous work to be significantly enhanced for NIF NP. Influence of NIF particle size on NIF permeation rate across intestinal cell models (Caco-2 and HT29-5M21 cultures and co-cultures) was investigated in order to complement these promising in vitro data. Apical to basolateral transfer studies were carried out across Caco-2 and HT29-5M21 cultures and co-cultures. Caco-2/HT29-5M21 co-cultures (seeding ratio 3: 1) were evaluated to better represent in vivo intestinal conditions. The influence of chitosan in the NIF NP formulation with regard to in vitro NIF permeation rate was also evaluated. These studies showed that NIF permeation rate across the different in vitro models evaluated can be significantly enhanced (approximate to 6-fold) by formulation of NIF as nanoparticles. No significant difference was observed either in the presence of chitosan in the formulation or between the three cell models evaluated. To complement these observations, preliminary in vivo pharmacokinetic evaluations in Sprague-Dawley rats, in the fed and fasted states, were also carried out for both un-milled NIF and NIF NP. [less ▲]

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See detailModelling the components of binaries in the Hyades: the dependence of the mixing-length parameter on stellar mass
Yıldız, M.; Yakut, K.; Bakış, H. et al

in Monthly Notices of the Royal Astronomical Society (2006), 368(4), 1941-1948

We present our findings based on a detailed analysis of the binaries of the Hyades, in which the masses of the components are well known. We fit the models of the components of a binary system to ... [more ▼]

We present our findings based on a detailed analysis of the binaries of the Hyades, in which the masses of the components are well known. We fit the models of the components of a binary system to observations so as to give the observed total V and B-V of that system and the observed slope of the main sequence in the corresponding parts. According to our findings, there is a very definite relationship between the mixing-length parameter and the stellar mass. The fitting formula for this relationship can be given as α= 9.19(M/M[SUB]solar[/SUB]- 0.74)[SUP]0.053[/SUP]- 6.65, which is valid for stellar masses greater than 0.77M[SUB]solar[/SUB]. While no strict information is gathered for the chemical composition of the cluster, as a result of degeneracy in the colour-magnitude diagram, by adopting Z= 0.033 and using models for the components of 70 Tau and θ[SUP]2[/SUP] Tau we find the hydrogen abundance to be X= 0.676 and the age to be 670 Myr. If we assume that Z= 0.024, then X= 0.718 and the age is 720 Myr. Our findings concerning the mixing-length parameter are valid for both sets of the solution. For both components of the active binary system V818 Tau, the differences between radii of the models with Z= 0.024 and the observed radii are only about 4 per cent. More generally, the effective temperatures of the models of low-mass stars in the binary systems studied are in good agreement with those determined by spectroscopic methods. [less ▲]

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See detailPour saluer Hubert Nyssen
Durand, Pascal ULg

in Durand, Pascal (Ed.) L'écrivain et son double. Hubert Nyssen (2006)

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See detail60 h of anhepatic state without neurologic deficit
Detry, Olivier ULg; De Roover, Arnaud ULg; Delwaide, Jean ULg et al

in Transplant International (2006), 19(9), 769-769

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See detailOptimal accumulation in an endogenous growth setting with human capital
Docquier, Frédéric; Paddison, Olivier; Pestieau, Pierre ULg

in Journal of Economic theory (2006), 134(1), 361-378

This paper considers a three-overlapping-generations model of endogenous growth wherein human capital is the engine of growth. It first contrasts the laissez-faire and the optimal solutions Three possible ... [more ▼]

This paper considers a three-overlapping-generations model of endogenous growth wherein human capital is the engine of growth. It first contrasts the laissez-faire and the optimal solutions Three possible accumulation regimes are distinguished. Then it discusses a standard set of tax-transfer instruments that allow for decentralization of the social optimum. Within the limits of our model, the rationale for the standard pattern of intergenerational transfers (the working-aged financing the education of the young and the pension of the old) is seriously questioned. On pure efficiency grounds, the case for generous public pensions is rather weak. (c) 2006 Elsevier Inc. All rights reserved. [less ▲]

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See detailCost-effective media for the rapid and high resolution of small DNA fragments using polyacrylamide-based electrophoresis
Negro, S. S.; Cloots, Rudi ULg; Gemmell, N. J.

in Molecular Ecology Notes (2006), 6(3), 609-612

Current Tris-based solutions for DNA electrophoresis produce a positive feedback loop between current and temperature at high voltage, resulting in long running times for the separation of even small DNA ... [more ▼]

Current Tris-based solutions for DNA electrophoresis produce a positive feedback loop between current and temperature at high voltage, resulting in long running times for the separation of even small DNA fragments. We optimized the separation of small DNA fragments (90-300 bp) in polyacrylamide-based electrophoresis at high voltages (200volts/cm) by substituting Tris with low concentration alkali salts (e.g. 1 mm LiCl and CsCl). These media reduced the heat produced during electrophoresis, enhanced the DNA fragment resolution, and allowed gels to be run at higher voltages, reducing gel running times by 25%. In addition, the elimination of Tris and EDTA from the buffer reduced material costs approximately 10-fold. © 2006 The Authors. [less ▲]

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See detailMorphological quantification of bone scaffolds with µCT
Kerckhofs, Greet ULg; Schrooten, Jan; Van Cleynenbreugel, T. et al

Conference (2006)

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See detailPeter Falck (ca 1468-1519) et ses livres : retour sur une passion
Adam, Renaud ULg

in Schweizerische Zeitschrift für Geschichte. Revue Suisse d’Histoire. Rivista Storica Svizzera (2006), 56

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See detailBilateral complete discoid medial meniscus combined with posterior cyst formation
Franceschi, F.; Longo, U. G.; Ruzzini, L. et al

in Knee Surgery, Sports Traumatology, Arthroscopy (2006), 15

Bilateral discoid medial menisci is an extremely rare condition of the knee and it can be associated to other pathological findings, including anterior portion cyst formation. We report on the clinical ... [more ▼]

Bilateral discoid medial menisci is an extremely rare condition of the knee and it can be associated to other pathological findings, including anterior portion cyst formation. We report on the clinical features, radiographic findings, treatment and results of one patient who presented a bilateral medial discoid meniscus combined with posterior portion cyst of the left knee. To the best of the author's knowledge, this is the first case of bilateral medial discoid meniscus associated with posterior portion cyst formation. [less ▲]

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See detailAutour d’une ingénierie lakatosienne de la notion de limite
Job, Pierre ULg

Scientific conference (2006)

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See detailLa ‘preuve cartésienne’ et la voie analytique de Kant
Dubouclez, Olivier ULg

in Fichant, Michel; Marion, Jean-Luc (Eds.) Descartes en Kant (2006)

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See detailInvestigation of blood oxidant/antioxidant markers in healthy competition horses of different breeds
Kirschvink, Nathalie; de Moffarts, Brieuc; Farnir, Frédéric ULg et al

in Equine Veterinary Journal. Supplement (2006), 36

REASONS FOR PERFORMING STUDY: There is increasing evidence that the equine athlete is exposed to exercise-induced changes of its oxidant/antioxidant balance and antioxidant supplementation is frequently ... [more ▼]

REASONS FOR PERFORMING STUDY: There is increasing evidence that the equine athlete is exposed to exercise-induced changes of its oxidant/antioxidant balance and antioxidant supplementation is frequently recommended. However, it is unknown whether there is a specific need for antioxidants according to performance, breed, gender or age. OBJECTIVES: To assess whether breed-, gender- and age-related differences of blood oxidant/antioxidant markers occur in competition horses. METHODS: Healthy horses (n = 493) underwent oxidant/ antioxidant blood marker determination. Vitamin E, lipophilic antioxidant capacity (ACL), ascorbic acid (AA), glutathione (GSH, GSSG), gluthione peroxidase (GPx), superoxide dismutase (SOD), selenium (Se), copper (Cu), zinc (Zn), lipid peroxides (Pool), oxidised proteins (Protox) were determined, as well as magnesium (Mg), creatine phosphokinase (CPK), lactate dehydrogenase (LDH), packed cell volume (PCV) and haemoglobin (Hb). A mixed linear model assessed the effect of breed, gender and age category. P<0.05 was considered significant. RESULTS: Thoroughbreds showed the highest values of vitamin E, ACL, GPx, PCV and Hb, whilst standardbreds had the highest values of AA and LDH. Jumping horses had the highest Protox values. Females had significantly higher SOD values, whereas most of the other markers were higher in stallions and geldings. Horses age 2-6 years had higher AA, SOD and LDH values than horses age >6 years. Correlation analyses were positive and significant between vitamin E and GPx, VitE and ACL, Se and GPx, Cu and Pool and negative between Pool and vitamin E, Pool and ACL, Protox and GPx, Protox and vitamin E. CONCLUSIONS: Blood oxidant/ antioxidant status of horses is influenced by breed, gender and age. The correlation analyses suggest synergistic relations between GPx, vitamin E and Se and an antagonistic relation between Protox-GPx, Protox-vitamin E, and Pool-vitamin E. POTENTIAL RELEVANCE: The results of this investigation provide definition of the specific need for antioxidants and vitamins in competition horses. [less ▲]

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See detailInventory control in a multi-supplier system
Arda, Yasemin ULg; Hennet, Jean-Claude

in International Journal of Production Economics (2006), 104

An enterprise network is analyzed from the viewpoint of an end-product manufacturer who receives customer orders and organises his production and supply policy so as to minimize the sum of his average ... [more ▼]

An enterprise network is analyzed from the viewpoint of an end-product manufacturer who receives customer orders and organises his production and supply policy so as to minimize the sum of his average holding cost and average stockout cost. For each main component to be ordered, the producer has several possible suppliers. The arrivals of customers’ orders are random and delivery times from suppliers are also supposed random. This supply system is represented as a queuing network where the producer uses a base-stock inventory control policy that keeps constant the inventory position level (current inventory level+pending replenishment orders). The decision variables are the reference inventory position level and the percentages of orders sent to the different suppliers. In the queuing network model, the percentages of orders are implemented as Bernoulli branching parameters. A close-form expression of the expected cost criterion is obtained as a complex non-linear function of decision variables. A decomposed approach is proposed for solving the optimization problem in an approximate manner. The quality of the approximate solution is evaluated by comparison to the exact solution, which can be computed numerically in some simple cases, in particular in the two-supplier case. Numerical applications show the important economic advantage for the producer of sending orders to several suppliers rather than to a single one. [less ▲]

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See detailLe groupe des « bisons adossés » de Lascaux : étude de la technique de l’artiste par analyse de pigments
Vignaud, Colette; Salomon, Hélène ULg; Chalmin, Emilie et al

in Anthropologie (L') (2006)

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See detailVue d'ensemble sur la planification et la réalisation d'autoroutes en Région wallonne
Hanson, Sophie ULg; Michel, Quentin ULg

in Spannowsky, Willy (Ed.) Planification et autorisation des autoroutes - Comparaison des systèmes d'aménagement du territoire dans la Grande Région "Sarre, Lorraine, Grand-Duché de Luxembourg, Région wallonne et Rhénanie-Palatinat (2006)

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See detailPalyWeb
Steemans, Philippe ULg; Breuer, P.

Conference (2006)

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See detailBiocompatibilidad de nuevos policationes sintéticos sobre las propiedades mecánicas y morfológicas de la membrana eritrocitaria.
Relancio, MP; Delannoy, M; Foresto, P et al

in Anales de la Asociación Argentina de Física (2006)

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See detailDétection et localisation d’endommagements structuraux par la méthode des sous-espaces, le modèle de Kalman et la méthode d’analyse en composantes principales
Yan, Ai-Min; De Boe, Pascal; Golinval, Jean-Claude ULg

in Mécanique & Industries (2006), 7

This paper deals with the application of statistical process control techniques for damage diagnosis based on vibration measurements. The first approach considered in this work is based the Stochastic ... [more ▼]

This paper deals with the application of statistical process control techniques for damage diagnosis based on vibration measurements. The first approach considered in this work is based the Stochastic Subspace Identification (SSI) algorithm, from which a Kalman model is constructed to fit the measured response histories of the undamaged (reference) structure. This model may be used to make a prediction of the newly measured responses. The residual error between the model predictions and the actual measurements is defined as a damage-sensitive feature. Outlier statistics provides then a quantitative indicator of damage. The advantage of the method is that model extraction has to be performed only once using the reference data and that no further modal identification is needed. Thus on-line structural health monitoring may easily be realized. In the second approach, principal component analysis (PCA) of the sensor time-responses is used to extract principal directions (i.e. features), which define a subspace that is representative of the dynamics of the instrumented structure. Any change in the response of a single sensor affects the subspace spanned by the complete sensor response set. It follows that the subspace corresponding to the current state of the structure can be compared to the subspace of the initial state of the structure, assumed to be healthy, in order to diagnose possible damage. Principal component analysis may also be performed for every potential subset of damaged sensors in order to identify the involved sensor, and, therefore, the damaged substructure. [less ▲]

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