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See detailEstimation du coût global d'un plan de lutte contre l'IBR en Belgique
Dispas, Marc; Houtain, Jean Yves; Muylkens, Benoît ULg et al

in Epidémiologie et Santé Animale (2006), 49

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See detailRole of Sox 10 in the development of the inner ear
Bodson, M; Breuskin, I; Thelen, Nicolas ULg et al

Poster (2006)

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See detailCloning of the genome of Alcelaphine herpesvirus 1 as an infectious and pathogenic bacterial artificial chromosome.
Dewals, Benjamin G ULg; Boudry, Christel ULg; Gillet, Laurent ULg et al

in Journal of General Virology (The) (2006), 87(Pt 3), 509-17

Alcelaphine herpesvirus 1 (AlHV-1), carried asymptomatically by wildebeest, causes malignant catarrhal fever (MCF) following cross-species transmission to a variety of susceptible species of the order ... [more ▼]

Alcelaphine herpesvirus 1 (AlHV-1), carried asymptomatically by wildebeest, causes malignant catarrhal fever (MCF) following cross-species transmission to a variety of susceptible species of the order Artiodactyla. The study of MCF pathogenesis has been impeded by an inability to produce recombinant virus, mainly due to the fact that AlHV-1 becomes attenuated during passage in culture. In this study, these difficulties were overcome by cloning the entire AlHV-1 genome as a stable, infectious and pathogenic bacterial artificial chromosome (BAC). A modified loxP-flanked BAC cassette was inserted in one of the two large non-coding regions of the AlHV-1 genome. This insertion allowed the production of an AlHV-1 BAC clone stably maintained in bacteria and able to regenerate virions when transfected into permissive cells. The loxP-flanked BAC cassette was excised from the genome of reconstituted virions by growing them in permissive cells stably expressing Cre recombinase. Importantly, BAC-derived AlHV-1 virions replicated comparably to the virulent (low-passage) AlHV-1 parental strain and induced MCF in rabbits that was indistinguishable from that of the virulent parental strain. The availability of the AlHV-1 BAC is an important advance for the study of MCF that will allow the identification of viral genes involved in MCF pathogenesis, as well as the production of attenuated recombinant candidate vaccines. [less ▲]

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See detailPattern and process in landscape ecology.
Bogaert, Jan ULg

Scientific conference (2006)

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See detailL’évaluation de la musculature rachidienne par le test de Sorensen: revue de la littérature et analyse critique
Demoulin, Christophe ULg; Vanderthommen, Marc ULg; Duysens, Christophe ULg et al

in Revue du Rhumatisme (2006), 73(1), 39-46

La première épreuve d’évaluation de l’endurance isométrique des muscles extenseurs du tronc a été décrite par Hansen dès 1964. En 1984, suite à l’étude de Biering-Sorensen, ce test a été largement diffusé ... [more ▼]

La première épreuve d’évaluation de l’endurance isométrique des muscles extenseurs du tronc a été décrite par Hansen dès 1964. En 1984, suite à l’étude de Biering-Sorensen, ce test a été largement diffusé dans la littérature sous le nom de « test de Sorensen ». Sa notoriété résulte de son prétendu caractère prédictif de l’occurrence, chez les sujets masculins, d’une lombalgie au cours de l’année à venir. Il s’effectue en décubitus ventral avec le tronc en débord de table, les membres inférieurs étant fixés ; dans cette position le sujet doit maintenir le plus longtemps possible son tronc à l’horizontale. Ce test a été utilisé dans de nombreuses études, de façon standardisée ou modifiée. Il semble discriminatif, reproductible et sans danger, mais les avis divergent toujours dans sa capacité à prédire l’apparition d’une lombalgie, de la présence d’une différence intersexuelle et de l’influence du poids corporel sur le temps de maintien. Si la participation des muscles extenseurs de hanche ne fait plus de doute, leur contribution exacte demeure inconnue. L’influence de facteurs individuels (tel que la motivation) constitue toujours un élément limitant l’interprétation des résultats. Malgré ces inconvénients, le test de Sorensen s’est imposé comme un outil de référence pour apprécier les performances musculaires du patient lombalgique et leur évolution suite à un programme de réhabilitation. [less ▲]

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See detailLe traitement de l'hypertension artérielle prévient-il la démence?
Krzesinski, Jean-Marie ULg

in Louvain Medical (2006), 125(6), 198-202

Chronic arterial hypertension plays a certain role in the cognitive function decline and dementia, particularly Alzheimer's disease, through vascular lesions added to the degenerative injuries. When ... [more ▼]

Chronic arterial hypertension plays a certain role in the cognitive function decline and dementia, particularly Alzheimer's disease, through vascular lesions added to the degenerative injuries. When stroke occurs, it accelerates the development of dementia. By using antihypertensive drugs and correcting high blood pressure, the incidence of stroke has been dramatically reduced. Such treatment has also demonstrated protective efffect on stroke recurrence but also on cognitive dysfunction related to cerebrovascular complication. When severe cognitive dysfunction is present, the interest of antihypertensive treatment, its nature and the blood pressure target have not been clearly defined. An individual approach must be stimulated with an overall cardiovascular risk factors correction. [less ▲]

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See detailEffect of surface preparation techniques on the cohesion of superficial concrete: comparison between jack-hammering and water-jetting
Courard, Luc ULg; Bissonnette, Benoît; Belair, Normand

in Beushausen, H.; Dehn, F.; Alexander, M. G. (Eds.) Concrete Repair, Rehabilitation and Retrofitting (2006)

The aim of concrete surface preparation is to obtain a surface with properties similar to those of the bulk concrete. Superficial concrete must be sound, dry, cohesive and contaminant-free. Particularly ... [more ▼]

The aim of concrete surface preparation is to obtain a surface with properties similar to those of the bulk concrete. Superficial concrete must be sound, dry, cohesive and contaminant-free. Particularly, the preparation must be performed in such a way that sound and homogeneous concrete is reached. The most widespread surface preparation techniques are sandblasting, jack-hammering, milling and other water hydro-jetting. Evaluation of the effect of surface preparation is often based upon surface roughness or specific sur-face. It is necessary however to investigate further within the first few centimetres from the surface to verify the concrete homogeneity and soundness. Pull-off test is a destructive method that can be useful for such evaluation, but it only gives an indication; the observation of the failure mode is more instructive. This paper summarizes the results of a microscopy investigation performed to quantify the number and length of cracks. The analysis leads to the comparison of jack-hammering and water-jetting techniques in terms of their poten-tial effect on superficial cohesion of concrete. [less ▲]

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See detailLaryngeal dysfunction after thyroid surgery: diagnostic and treatments
FINCK, Camille ULg

in Acta Chirurgica Belgica (2006), 106

Vocal fold hypomobility after thyroidectomy is a frequent complication of thyroidectomy. Laryngeal nerve paresis or paralysis may present with various symptoms like dysphagia, aspiration, voice alteration ... [more ▼]

Vocal fold hypomobility after thyroidectomy is a frequent complication of thyroidectomy. Laryngeal nerve paresis or paralysis may present with various symptoms like dysphagia, aspiration, voice alteration or dyspnea. Are described: the normal anatomophysiology of the larynx, the symptoms of nerve trauma following thyroidectomy, techniques of thoroughfull laryngeal and voice examination, some clinical entities( unilateral recurrent nerve paralysis, bilateral recurrent nerve paralysis, superior laryngeal nerve paralysis),natural evolution of paralysis, prognosis and management of laryngeal paralysis) [less ▲]

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See detailEvaluation de la séroprévalence de l'infection à herpèsvirus caprin 1 dans le sud-ouest de l'Europe
Thiry, Julien ULg; Keuser, Véronique; Schynts, Frédéric et al

in Epidémiologie et Santé Animale (2006), 49

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See detailThe loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland.
van den Hove, Marie-France; Croizet-Berger, Karine; JOURET, François ULg et al

in Endocrinology (2006), 147(3), 1287-96

Genetic inactivation of ClC-5, a voltage-gated chloride channel prominently expressed in the kidney, leads to proteinuria because of defective apical endocytosis in proximal tubular cells. Because thyroid ... [more ▼]

Genetic inactivation of ClC-5, a voltage-gated chloride channel prominently expressed in the kidney, leads to proteinuria because of defective apical endocytosis in proximal tubular cells. Because thyroid hormone secretion depends on apical endocytosis of thyroglobulin (Tg), we investigated whether ClC-5 is expressed in the thyroid and affects its function, using Clcn5-deficient knockout (KO) mice. We found that ClC-5 is highly expressed in wild-type mouse thyroid ( approximately 40% of mRNA kidney level). The protein was immunolocalized at the apical pole of thyrocytes. In Percoll gradients, ClC-5 overlapped with plasma membrane and early endosome markers, but best codistributed with the late endosomal marker, Rab7. ClC-5 KO mice were euthyroid (normal T4 and TSH serum levels) but developed a goiter with parallel iodine and Tg accumulation (i.e. normal Tg iodination level). When comparing ClC-5 KO with wild-type mice, thyroid 125I uptake after 1 h was doubled, incorporation into Tg was decreased by approximately 2-fold, so that trichloroacetic acid-soluble 125I increased approximately 4-fold. Enhanced 125I- efflux upon perchlorate and presence of 125I-Tg as autoradiographic rings at follicle periphery demonstrated delayed iodide organification. Endocytic trafficking of 125I-Tg toward lysosomes was not inhibited. Expression of pendrin, an I-/Cl- exchanger involved in apical iodide efflux, was selectively decreased by 60% in KO mice at mRNA and protein levels. Thus, ClC-5 is well expressed in the thyroid but is not critical for apical endocytosis, contrary to the kidney. Instead, the goiter associated with ClC-5 KO results from impaired rate of apical iodide efflux by down-regulation of pendrin expression. [less ▲]

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See detailCalculation of the random-incidence scattering coefficients of a sine-shaped surface
Embrechts, Jean-Jacques ULg; De Geetere, L.; Vermeir, G. et al

in Acta Acustica United with Acustica (2006), 92(4, JUL-AUG), 593-603

Random-incidence scattering coefficients obtained by measurement in reverberation chambers (ISO 17497-1) for a particular sine-shaped surface are compared with theoretical results. Holford-Urusovskii's ... [more ▼]

Random-incidence scattering coefficients obtained by measurement in reverberation chambers (ISO 17497-1) for a particular sine-shaped surface are compared with theoretical results. Holford-Urusovskii's method and a hybrid plane wave decomposition - FEM method are applied to an infinite sine-shaped surface having the same profile, while the 3D BEM gives numerical results for the finite-size surface. Perfect rigidity (Neumann boundary condition) is assumed in all computations. The validity of the computations is compared and discussed with regard to the approximations involved. Finally, the measured and calculated values of the scattering coefficients are compared. A good correspondence is found, in particular concerning the overall dependence on frequency. Small deviations have however been observed, at low as well as at high frequencies. They will be explained by uncertainties in the measurements and discretisation errors in the calculations. [less ▲]

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See detailFlux closure during a substorm observed by Cluster, Double Star, IMAGE FUV, SuperDARN, and Greenland magnetometers
Milan, S. E.; Wild, J. A.; Hubert, Benoît ULg et al

in Annales Geophysicae (2006), 24(2), 751-767

We examine magnetic flux closure during an extended substorm interval on 29 August 2004 involving a two-stage onset and subsequent re-intensifications. Cluster and Double Star provide observations of ... [more ▼]

We examine magnetic flux closure during an extended substorm interval on 29 August 2004 involving a two-stage onset and subsequent re-intensifications. Cluster and Double Star provide observations of magnetotail dynamics, while the corresponding auroral evolution, convection response, and substorm current wedge development are monitored by IMAGE FUV, SuperDARN, and the Greenland magnetometer chain, respectively. The first stage of onset is associated with the reconnection of closed flux in the plasma sheet; this is accompanied by a short-lived auroral intensification, a modest substorm current wedge magnetic bay, but no significant ionospheric convection enhancement. The second stage follows the progression of reconnection to the open field lines of the lobes; accompanied by prolonged auroral bulge and westward-travelling surge development, enhanced magnetic bays and convection. We find that the tail dynamics are highly influenced by ongoing dayside creation of open flux, leading to flux pile-up in the near-tail and a step-wise down-tail motion of the tail reconnection site. In all, 5 dipolarizations are observed, each associated with the closure of similar to 0.1 GWb of flux. Very simple calculations indicate that the X-line should progress down-tail at a speed of 20 km s(-1) or 6 R-E between each dipolarization. [less ▲]

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See detailLa transmission familiale : s'approprier le passé entre frères et soeurs.
Favart, Evelyne ULg

in Pensée plurielle (2006), 1/11

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See detailRapid testosterone-induced apparent diffusion coefficient (ADC) changes in the sexually dimorphic medial preoptic nucleus of male Japanese quail.
Van Der Linden, Annemie; De Groof, Geert; Charlier, Thierry ULg et al

Poster (2006)

Testosterone (T) influences the volume and cellular characteristics of a variety of steroid-dependent brain nuclei in many vertebrates. In castrated quail, the volume of the sexually dimorphic (males ... [more ▼]

Testosterone (T) influences the volume and cellular characteristics of a variety of steroid-dependent brain nuclei in many vertebrates. In castrated quail, the volume of the sexually dimorphic (males > females) medial preoptic nucleus (POM), a key area in the control of male sexual behavior, is markedly increased by T but previous studies always assessed this effect after a period of 8-14 days and its specific time-course was unknown. We recently found that following treatment with T, the POM volume increases in a time-dependent fashion: a significant increase was already detected after only one day and the response reached it maximum (volume doubling) after 14 days of treatment. This however raised the question of the cellular mechanism underlying such a rapid brain plasticity (increase in cell size, neuropil volume, dendritic branching, extracellular space?). To research whether a change in extra- vs. intra-cellular space could be responsible for the rapid T-induced increase in POM volume, we repeatedly analyzed by in vivo diffusion-weighted magnetic resonance imaging (DW-MRI) the brain of castrated male quail before as well as after 1, 2, 7 and 14 days of T implantation. MRI was performed on a 7T-system (Bruker) using a multislice diffusion weighted-spin echo sequence. Coronal slices with an image resolution of 100*100*500µm³ were obtained covering the whole telencephalon. Images were accurately coregistered allowing voxel-wise paired comparisons of the ADC data between the different time periods. The ADC significantly increased after one day of T treatment (696±16 vs 758±30 µm²/s, p=0.011, N=5) in POM and this effect apparently persisted during the whole experiment. By contrast, T insensitive regions like the nucleus rotundus (586±170 vs 511±26 µm²/s, p-value=0.24) and nucleus mesencephalicus lateralis, pars dorsalis (934±107 vs 911±64 µm²/s, p=0.68) were not affected after the first day nor later in the experiment. These data indicate that T increases the extracellular water volume in POM specifically, either as a result of cell shrinkage or of an increase in the space between cells, and that changes in the ratio of extra- to intra-cellular water mediate, at least in part, the fast plasticity of the POM volume observed after exposure to T. [less ▲]

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See detailLa saga des inhibiteurs des histone-desacetylases: de la TSA au SAHA
Peixoto, Paul ULg; Lansiaux, Amelie

in Bulletin du Cancer (2006), 93(1), 27-36

Histone-deacetylase inhibitors (HDCACi) represent a new class of antitumor agents currently in clinical development. They target a family of enzymes which catalyse histone acetylation modifications, in ... [more ▼]

Histone-deacetylase inhibitors (HDCACi) represent a new class of antitumor agents currently in clinical development. They target a family of enzymes which catalyse histone acetylation modifications, in particular for histones H2A, H2B, H3 and H4. These proteins stabilize the nucleosome core, fundamental unity of chromatin which represents the first level of DNA nuclear compaction. The balance of histone acetylation is maintained by histone-acetyltransferases (HAT) and histone-deacetylases (HDAC) which play an important role in gene transcription. Alterations of HDACs were identified in tumor cells and contribute to the massive perturbations of gene expression in numerous tumors. HDAC inhibition leads to differentiation, cell cycle arrest and apoptosis in tumor cells. HDACi efficiently prevent tumor growth in a variety of in vivo preclinical models. Several structurally distinct classes of HDACi have entered in clinical trials and a significant antitumor activity was reported in several cases. However, a better understanding of the biological effects of this class of enzymes is mandatory for the successful development of these new antitumoral agents. In this review, are exposed the main drug candidates in clinical development. In the near future, it will be interesting to define direct relationships between specific inhibition of one or several HDAC and the subsequent HDAC-dependent antitumor effects to define a new generation of specific histone-deacetylase inhibitors. [less ▲]

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See detailInhomogeneous and anisotropic deformation behavior and strain hardening of ultrafine-grained aluminium by ECAP
Poortmans, Stijn; El Houdaigui, Fouad; Habraken, Anne ULg et al

in Zhu, Y. T.; Langdon, T. G.; Horita, Z. (Eds.) et al Proceedings of the Ultrafine Grained Materials IV Conference (2006)

Hot-rolled AA1050 commercial pure aluminum was deformed by ECAP (Equal Channel Angular Pressing) at room temperature following route BC for 8 passes. Mechanical testing at room temperature on both hot ... [more ▼]

Hot-rolled AA1050 commercial pure aluminum was deformed by ECAP (Equal Channel Angular Pressing) at room temperature following route BC for 8 passes. Mechanical testing at room temperature on both hot-rolled aluminum and aluminum after ECAP consisted of uniaxial tension, axisymmetric compression and shear by torsion. The phenomenological Hill’s criterion identified from texture data accounts for the observed tension-compression asymmetry due to ECAP and predicts torsion yielding close to measurements. FE simulations of the compression tests are performed with a Hill model or a Minty micro-macro model and coupled with an isotropic Voce saturation hardening law. These simulations compute the inhomogeneous behavior due to barreling, the observed sample anisotropy and the force-displacement curve. Comparisons of numerical and experiments results provide a first identification of the hardening parameters and the friction coefficient during compression tests. [less ▲]

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