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See detailInterlaboratory study of a NACE method for the determination of R-timolol content in S-timolol maleate: assessment of uncertainty.
Marini Djang'Eing'A, Roland ULg; Groom, Carl; Doucet, Francois R et al

in Electrophoresis (2006), 27(12), 2386-99

Analyses of statistical variance were applied to evaluate the precision and practicality of a CD-based NACE assay for R-timolol after enantiomeric separation of R- and S-timolol. Data were collected in an ... [more ▼]

Analyses of statistical variance were applied to evaluate the precision and practicality of a CD-based NACE assay for R-timolol after enantiomeric separation of R- and S-timolol. Data were collected in an interlaboratory study by 11 participating laboratories located in Europe and North America. General qualitative method performance was examined using suitability descriptors (i.e. resolution, selectivity, migration times and S/N), while precision was determined by quantification of variances in the determination of R-timolol at four different impurity levels in S-timolol maleate samples. The interlaboratory trials were designed in accordance with the ISO guideline 5725-2. This allowed estimating for each sample, the different variances, i.e. between-laboratory (s2(Laboratories)), between-day (s2(Days)) and between-replicate (s2(Replicates)). The variances of repeatability (s2r) and reproducibility (s2R) were then calculated. The estimated uncertainty, derived from the precision estimates, seems to be concentration-dependent above a given threshold. This example of R-timolol illustrates how a laboratory can evaluate uncertainty in general. [less ▲]

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See detailImplicit memory during isoflurane anesthesia - Reply
Iselin-Chaves, Irène A.; Willems, Sylvie ULg

in Anesthesiology (2006), 105(2), 430-430

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See detailWaimes/Robertville: la Via Mansuerisca et la découverte d'un véhicule
Corbiau, Marie-Hélène; Hoffsummer, Patrick ULg

in Vie archéologique, chronique de l'archéologie wallonne (2006), 13

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See detailTalent voor Nederlands
Yans, Baudoin ULg; Engelen, Nicole ULg; Nachtergaele, Lutgarde

Book published by Editions Erasme (2006)

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See detailEukaryotic organisms in Proterozoic oceans
Knoll, A. H.; Javaux, Emmanuelle ULg; Hewitt, D. et al

in Philosophical Transactions : Biological Sciences (2006), 361(1470), 1023-1038

The geological record of protists begins well before the Ediacaran and Cambrian diversification of animals, but the antiquity of that history, its reliability as a chronicle of evolution and the causal ... [more ▼]

The geological record of protists begins well before the Ediacaran and Cambrian diversification of animals, but the antiquity of that history, its reliability as a chronicle of evolution and the causal inferences that can be drawn from it remain subjects of debate. Well-preserved protists are known from a relatively small number of Proterozoic formations, but taphonomic considerations suggest that they capture at least broad aspects of early eukaryotic evolution. A modest diversity of problematic, possibly stem group protists occurs in ca 1800-1300 Myr old rocks. 1300-720 Myr fossils document the divergence of major eukaryotic clades, but only with the Ediacaran-Cambrian radiation of animals did diversity increase within most clades with fossilizable members. While taxonomic placement of many Proterozoic eukaryotes may be arguable, the presence of characters used for that placement is not. Focus on character evolution permits inferences about the innovations in cell biology and development that underpin the taxonomic and morphological diversification of eukaryotic organisms. [less ▲]

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See detailReactivity of penicillin-binding proteins with peptidoglycan-mimetic beta-lactams: what's wrong with these enzymes?
Josephine, Helen R.; Charlier, Paulette ULg; Davies, Christopher et al

in Biochemistry (2006), 45(51), 15873-83

Beta-lactams exert their antibiotic action through their inhibition of bacterial DD-peptidases (penicillin-binding proteins). Bacteria, in general, carry several such enzymes localized on the outside of ... [more ▼]

Beta-lactams exert their antibiotic action through their inhibition of bacterial DD-peptidases (penicillin-binding proteins). Bacteria, in general, carry several such enzymes localized on the outside of their cell membrane to catalyze the final step in cell wall (peptidoglycan) synthesis. They have been classified into two major groups, one of high molecular weight, the other of low. Members of the former group act as transpeptidases in vivo, and their inhibition by beta-lactams leads to cessation of bacterial growth. The latter group consists of DD-carboxypeptidases, and their inhibition by beta-lactams is generally not fatal to bacteria. We have previously shown that representatives of the former group are ineffective at catalyzing the hydrolysis/aminolysis of peptidoglycan-mimetic peptides in vitro [Anderson et al. (2003) Biochem. J. 373, 949-955]. The theme of these experiments is expanded in the present paper where we describe the synthesis of a series of beta-lactams (penicillins and cephalosporins) containing peptidoglycan-mimetic side chains and the kinetics of their inhibition of a panel of penicillin-binding proteins spanning the major classes (Escherichia coli PBP 2 and PBP 5, Streptococcus pneumoniae PBP 1b, PBP 2x and PBP 3, the Actinomadura R39 DD-peptidase, and the Streptomyces R61 DD-peptidase). The results of these experiments mirror and expand the previous results with peptides. Neither peptides nor beta-lactams with appropriate peptidoglycan-mimetic side chains react with the solubilized constructs of membrane-bound penicillin binding proteins (the first five enzymes above) at rates exceeding those of generic analogues. Such peptides and beta-lactams do react at greatly enhanced rates with certain soluble low molecular weight enzymes (R61 and R39 DD-peptidases). The former result is unexpected and interesting. Why do the majority of penicillin-binding proteins not recognize elements of local peptidoglycan structure? Possible answers are discussed. That this question needs to be asked casts fascinating shadows on current studies of penicillin-binding proteins for new drug design. [less ▲]

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See detailEstimation du coût global d'un plan de lutte contre l'IBR en Belgique
Dispas, Marc; Houtain, Jean Yves; Muylkens, Benoît ULg et al

in Epidémiologie et Santé Animale (2006), 49

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See detailStaging formality. Commerce and state in Katanga (DRC).
Rubbers, Benjamin ULg

Conference (2006)

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See detailConflits entre noms de domaines et marques (renommées)
Defossez, Alexandre ULg

in Revue Internationale de Droit Economique (2006)

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See detailPoésie, Langage, Antiprose
Delville, Michel ULg

in Formes Poétiques Contemporaines (2006), 4

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See detailLe partage de l'empirique et du transcendantal. Essai sur la normativité de la raison : Kant, Hegel, Husserl
Seba, Jean-Renaud ULg

Book published by Ousia (2006)

The present study attemps to account for the complexity of the issues tackled. It explores the nature and indeed the very foundation of reason, relating three major philosophers. The transcendantal ... [more ▼]

The present study attemps to account for the complexity of the issues tackled. It explores the nature and indeed the very foundation of reason, relating three major philosophers. The transcendantal foundation of empiricism is itself founded - ultimately - on an anthropological empirical foundation in a dialectical circle. [less ▲]

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See detailRelationship between surface characteristics and superficial cohesion of concrete
Garbacz, Andrzej; Gorka, M.; Courard, Luc ULg

in Beushausen, H.; Dehn, F.; Alexander, M. G. (Eds.) Concrete Repair, Rehabilitation and Retrofitting (2006)

Existing concrete surfaces have to be prepared before the application of a new layer. Different surface treatments (grinding, sandblasting, shotblasting, hand- and mechanical milling) have been performed ... [more ▼]

Existing concrete surfaces have to be prepared before the application of a new layer. Different surface treatments (grinding, sandblasting, shotblasting, hand- and mechanical milling) have been performed and the quality of the preparation has been established on the base of three main parameters: surface roughness, superficial concrete microcracking and adhesion. Cracks have been systematically observed, in relation with surface treatment by means of Scanning Electron Microscope and Light Microscope. Finally, a repair mortar, with or without bond coat, has been applied on the concrete substrates and adhesion has been measured. Analysis of results clearly show the effect of roughness on adhesion in the case where no bond coat is used, the influence of the surface treatment on the waviness shape of the profile and the presence of microcracks in the near-to-surface layer, which is related to failure type. [less ▲]

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See detailLe traitement de l'hypertension artérielle prévient-il la démence?
Krzesinski, Jean-Marie ULg

in Louvain Medical (2006), 125(6), 198-202

Chronic arterial hypertension plays a certain role in the cognitive function decline and dementia, particularly Alzheimer's disease, through vascular lesions added to the degenerative injuries. When ... [more ▼]

Chronic arterial hypertension plays a certain role in the cognitive function decline and dementia, particularly Alzheimer's disease, through vascular lesions added to the degenerative injuries. When stroke occurs, it accelerates the development of dementia. By using antihypertensive drugs and correcting high blood pressure, the incidence of stroke has been dramatically reduced. Such treatment has also demonstrated protective efffect on stroke recurrence but also on cognitive dysfunction related to cerebrovascular complication. When severe cognitive dysfunction is present, the interest of antihypertensive treatment, its nature and the blood pressure target have not been clearly defined. An individual approach must be stimulated with an overall cardiovascular risk factors correction. [less ▲]

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See detailSpontaneous pneumocephalus caused by the association of pneumosinus dilatans and meningioma. Case illustration
Scholsem, Martin; Collignon, Frederic; Deprez, Manuel ULg et al

in Journal of Neurosurgery (2006), 105(6), 934

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See detailSuction and time effects on the behaviour of a reservoir chalk
Priol, Grégoire; De Gennaro, Vincenzo; Delage, Pierre et al

in Van Cotthem, Alain; Charlier, Robert; Thimus, Jean-François (Eds.) EUROCK 2006 - Multiphysics Coupling and Long Term Behaviour in Rock Mechanics (2006)

Oil reservoir rocks contain various immiscible fluids (oil, water and gas) and they are submitted to elevated temperatures in the oilfield. Hence, they exhibit a typical coupled behaviour where ... [more ▼]

Oil reservoir rocks contain various immiscible fluids (oil, water and gas) and they are submitted to elevated temperatures in the oilfield. Hence, they exhibit a typical coupled behaviour where multiphysics and coupled Thermo-Hydro-Mechanical aspects are predominant. This paper presents some results from researches carried out within the PASACHALK 2 European funded collaborative research. In this research dedicated to subsidence problems in the North sea Ekofisk oilfield, the behaviour of a reservoir chalk containing two immiscible fluids (an organic non polar fluid and water) is considered within the framework of the mechanics of unsaturated soils (no temperature effects considered). In order to account for the mechanical coupled effects related to the two pore fluids, the oil-water suction was considered as an independent stress variable. The paper presents some experimental results describing the combined effect of suction and time on the isotropic compression behaviour of the chalk. A viscoelastoplastic constitutive model based on one hand on the Barcelona BBM elastoplastic model for unsaturated and on the other hand on Perzina’s approach of viscous behaviour of soils is also presented and validated against experimental evidence. [less ▲]

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See detailKinetics of Microsporum canis adherence using an in vitro model of reconstituted feline epidermis
Baldo, Aline ULg; Tabart, J.; Vermout, S. et al

Conference (2006)

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See detailDespite inhibition of hematopoietic progenitor cell growth in vitro, the tyrosine kinase inhibitor imatinib does not impair engraftment of human CD133+ cells into NOD/SCIDbeta2mNull mice.
Pirson, Laurence ULg; Baron, Frédéric ULg; Meuris, Nathalie ULg et al

in Stem Cells (2006), 24(7), 1814-21

There is potential interest for combining allogeneic hematopoietic cell transplantation (HCT), and particularly allogeneic HCT with a nonmyeloablative regimen, to the tyrosine kinase inhibitor imatinib ... [more ▼]

There is potential interest for combining allogeneic hematopoietic cell transplantation (HCT), and particularly allogeneic HCT with a nonmyeloablative regimen, to the tyrosine kinase inhibitor imatinib (Glivec; Novartis, Basel, Switzerland, http://www.novartis.com) in order to maximize anti-leukemic activity against Philadelphia chromosome-positive leukemias. However, because imatinib inhibits c-kit, the stem cell factor receptor, it could interfere with bone marrow engraftment. In this study, we examined the impact of imatinib on normal progenitor cell function. Imatinib decreased the colony-forming capacity of mobilized peripheral blood human CD133(+) cells but not that of long-term culture-initiating cells. Imatinib also decreased the proliferation of cytokine-stimulated CD133(+) cells but did not induce apoptosis of these cells. Expression of very late antigen (VLA)-4, VLA-5, and CXCR4 of CD133(+) cells was not modified by imatinib, but imatinib decreased the ability of CD133(+) cells to migrate. Finally, imatinib did not decrease engraftment of CD133(+) cells into irradiated nonobese diabetic/severe combined immunodeficient/beta2m(null) mice conditioned with 3 or 1 Gy total body irradiation. In summary, our results suggest that, despite inhibition of hematopoietic progenitor cell growth in vitro, imatinib does not interfere with hematopoietic stem cell engraftment. [less ▲]

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See detailEvaluation de la séroprévalence de l'infection à herpèsvirus caprin 1 dans le sud-ouest de l'Europe
Thiry, Julien ULg; Keuser, Véronique; Schynts, Frédéric et al

in Epidémiologie et Santé Animale (2006), 49

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See detailA tutorial on scattering and diffusion coefficients for room acoustic surfaces
Cox, T. J.; Dalenback, B.-I.; D'Antonio, P. et al

in Acta Acustica United with Acustica (2006), 92(1, JAN-FEB), 1-15

There is a need to be able to quantify how sound is reflected from a surface, in terms of how it is spatially dispersed. In recent years, diffusion and scattering coefficients have been developed to ... [more ▼]

There is a need to be able to quantify how sound is reflected from a surface, in terms of how it is spatially dispersed. In recent years, diffusion and scattering coefficients have been developed to enable room acoustic prediction models to be more accurate, and designers to evaluate the worth of diffusing surfaces. Two coefficients have been, or are about to be, enshrined in standards. With two coefficients being standardised, there is great potential for confusion. This paper is intended to bring together authors from different areas to explain where the coefficients should and should not be applied. In addition, this tutorial paper will revisit the rationale behind the coefficients and contrast the coefficient definitions and performance. [less ▲]

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