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See detailQuantification of Bifidobacterium spp. and Lactobacillus spp. in rat fecal samples by real-time PCR.
Delroisse, Jean-Marc; Boulvin, Anne-Lise; Parmentier, Isabelle et al

in Microbiological research (2006), (5),

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See detailCompte rendu de l'ouvrage collectif : Medieval Virginities
Delfosse, Annick ULg

in Moyen Age (Le) (2006), 112(2), 402-403

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See detailEffect Of Various Levels Of Imbalance Between Energy And Nitrogen Release In The Rumen On Microbial Protein Synthesis And Nitrogen Metabolism In Growing Double-Muscled Belgian Blue Bulls Fed A Corn Silage-Based Diet
Valkeners, Damien; Thewis, André ULg; Amant, Stéphanie et al

in Journal of Animal Science (2006), 84(4), 877-885

Seven double-muscled Belgian Blue bulls (initial BW: 341 ± 21 kg) with cannulas in the rumen and proximal duodenum were used in an incomplete replicated Latin square. The study examined the effect of ... [more ▼]

Seven double-muscled Belgian Blue bulls (initial BW: 341 ± 21 kg) with cannulas in the rumen and proximal duodenum were used in an incomplete replicated Latin square. The study examined the effect of imbalance between energy and N in the rumen on microbial protein synthesis and N metabolism by giving the same diet according to 3 different feeding patterns. The feed ingredients of the diet were separated into 2 groups supplying the same amount of fermentable OM(FOM) but characterized by different levels of ruminally degradable N (RDN). The first group primarily provided energy for the ruminal microbes (12.5 g of RDN/kg of FOM), whereas the second provided greater N (33.3 g of RDN/kg of FOM). These 2 groups were fed to the bulls in different combinations with the aim of creating 3 levels of imbalance (0, 20, and 40 g/ kg of DM) between energy andN supplies in the rumen. Imbalance was measured by the variation of the degradable protein balance (OEB value in the Dutch system) of the diet between the 2 meals each a day. Diurnal variations in ruminal NH3-N concentrations and plasma urea concentrations were greatly influenced by the feeding patterns of the diet. Introduction of imbalance affected neither microbial N flow at the duodenum (P = 0.97) nor efficiency of growth (P = 0.54). The feeding patterns of the diet had no negative impact on NDF degradation in the rumen (P = 0.33). Nitrogen retention was not affected by imbalance (P = 0.74) and reached 49.7, 52.0, and 51.3 g/d, respectively for 0, 20, and 40 g of OEB/kg of DM imbalance. It seems that introduction of an imbalance between energy and N supplies for the ruminal microbes by altering the feeding pattern of the same diet does not negatively influence the microbial activity in the rumen norNretention of the animal. Nitrogen recycling in the rumen plays a major role in regulating the amount of ruminally available N and allows a continuous synchronization of N and energyyielding substrates for the microorganisms in the rumen. Therefore, imbalance between dietary energy and N created over a 24-h interval was not detrimental to rumen microbial growth for the animal as long as the level of imbalance did not exceed 40 g of OEB/kg of DM. Thus, these feeding patterns of the diet can be used under practical feeding conditions with minimal impact on the performance of ruminant animals for meat production. [less ▲]

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See detailOrigine biogénétique des triterpènes pentacycliques présents dans la sécrétion défensive de Platyphora Kollari (Chrysomelidae)
Ghostin, Jean; Laurent, Pascal ULg; Daloze, Désiré et al

Poster (2006)

Les chrysomèles sont des insectes phytophages brillement colorés qui représentent une des famille (Chrysomelidae) les plus importante de l'ordre des coléoptères. Etant aposématiques, ils sont facilement ... [more ▼]

Les chrysomèles sont des insectes phytophages brillement colorés qui représentent une des famille (Chrysomelidae) les plus importante de l'ordre des coléoptères. Etant aposématiques, ils sont facilement repérables par des prédateurs potentiels et ont, au cours de l'évolution, développé des mécanismes de défense chimique élaborés. La découverte de glycosides triterpéniques basés sur le squelette oléanane a soulevé le problème de leur origine biogénétique. En effet, il est bien connu que les insectes ne possèdent pas la squalène synthase, une enzyme indispensable à la formation des stéroïdes et des triterpènes pentacycliques. Dès lors, une biosynthèse de novo de ce type de dérivé est peu probable. Par ailleurs, l'analyse de la plante hôte des chrysomèles a montré que la séquestration des glycosides au départ de cette plante est également exclue. Une troisième possibilité serait que l'insecte utilise un précurseur provenant de son alimentation pour fabriquer ses substances défensives. Un tel précurseur pourrait être la b-amyrine identifiée chez différentes plantes hôtes des chrysomèles ou l'acide oléanolique dont la structure de base se retrouve au niveau des triterpènes défensifs. Enfin, l'analyse des plantes hôtes a montré que celles-ci contiennent à la fois de la b-amyrine et de l'a-amyrine dans un rapport 1,76/1. Cependant aucun glycoside triterpénique basé sur le squelette ursane n'a été isolé jusqu'à présent chez les chrysomèles, ce qui suggère un mécanisme de transport sélectif en faveur de la b-amyrine. Dans le cadre de ce travail, nous présenterons les synthèses d'a-amyrine, de b-amyrine et d'acide oéanolique trideutériés, ainsi que les résultats d'incorporation des deux premiers précurseurs chez Platyphora kollari. [less ▲]

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See detailMaintenance threonine requirement and efficiency of its use for accretion of whole-body threonine and protein in Atlantic salmon (Salmo salar L.) fry.
Rollin, Xavier; Wauters, Jean*-Baptiste; Bodin, Noe Lie et al

in British Journal of Nutrition (2006), 95(2), 234-45

Eighteen groups of seventy Atlantic salmon (Salmo salar L.) fry (initial mean body weight 0.8 (sd 0.01) g) were fed on semi-purified diets containing graded levels of l-threonine (Thr) in 15 litres ... [more ▼]

Eighteen groups of seventy Atlantic salmon (Salmo salar L.) fry (initial mean body weight 0.8 (sd 0.01) g) were fed on semi-purified diets containing graded levels of l-threonine (Thr) in 15 litres aquaria at a temperature of 14.5+/-1 degrees C. Doses of Thr represented 1, 31, 41, 51, 62, 72, 83 and 93 % of its ideal level for optimum protein deposition. Indispensable amino acids other than Thr were included in the same proportion (on a g/16 g N basis) as in the Atlantic salmon fry whole-body carcass. Following 36 d of feeding and a 36 h fast, fry were killed for whole-body protein and amino acid analysis. Weight gain (r2 0.98), protein accretion (r2 0.97), and Thr accretion (r2 0.97) were linear (P<0.01) functions of Thr intake. Slope of the Thr accretion regression line showed that the efficiency of Thr utilisation above maintenance was 76 %. At zero Thr intake, fry lost 5.4 mg Thr/kg body weight0.75 per d. The Thr maintenance requirement was 7.2 mg/kg body weight0.75 per d and the Thr requirement for growth was 66 mg for 1 g protein deposition. Increasing doses of Thr resulted in increased (P<0.05) concentrations of histidine and lysine, and decreased concentrations of isoleucine in whole-body protein. The maintenance need for Thr represented 13.4 % of the total need for Thr. The data suggest that efficiency of Thr utilisation above maintenance is constant at all levels of Thr intake between 1 and 93 % of the level required for optimum protein deposition. [less ▲]

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See detailLa saga des inhibiteurs des histone-desacetylases: de la TSA au SAHA
Peixoto, Paul ULg; Lansiaux, Amelie

in Bulletin du Cancer (2006), 93(1), 27-36

Histone-deacetylase inhibitors (HDCACi) represent a new class of antitumor agents currently in clinical development. They target a family of enzymes which catalyse histone acetylation modifications, in ... [more ▼]

Histone-deacetylase inhibitors (HDCACi) represent a new class of antitumor agents currently in clinical development. They target a family of enzymes which catalyse histone acetylation modifications, in particular for histones H2A, H2B, H3 and H4. These proteins stabilize the nucleosome core, fundamental unity of chromatin which represents the first level of DNA nuclear compaction. The balance of histone acetylation is maintained by histone-acetyltransferases (HAT) and histone-deacetylases (HDAC) which play an important role in gene transcription. Alterations of HDACs were identified in tumor cells and contribute to the massive perturbations of gene expression in numerous tumors. HDAC inhibition leads to differentiation, cell cycle arrest and apoptosis in tumor cells. HDACi efficiently prevent tumor growth in a variety of in vivo preclinical models. Several structurally distinct classes of HDACi have entered in clinical trials and a significant antitumor activity was reported in several cases. However, a better understanding of the biological effects of this class of enzymes is mandatory for the successful development of these new antitumoral agents. In this review, are exposed the main drug candidates in clinical development. In the near future, it will be interesting to define direct relationships between specific inhibition of one or several HDAC and the subsequent HDAC-dependent antitumor effects to define a new generation of specific histone-deacetylase inhibitors. [less ▲]

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See detailThe Castelnau's fish collection and watercolour notebooks
Loneux, Michèle ULg

in Segers, Hendrik; Desmet, P.; Baus, Erika (Eds.) Proceedings of the 3rd GBIF Science Symposium - Tropical Biodiversity: Science, Data, Conservation (2006)

In 1865, Jean-Theodore Lacordaire (professor of natural sciences at the University of Liège) purchased more than thousand specimens collected by the famous explorer ‘Comte de Castelnau’. Castelnau (London ... [more ▼]

In 1865, Jean-Theodore Lacordaire (professor of natural sciences at the University of Liège) purchased more than thousand specimens collected by the famous explorer ‘Comte de Castelnau’. Castelnau (London 1812 – Melbourne 1880) travelled around the world being both explorer and diplomat. His most famous trip was the crossing of South America from Mato Gross to Peru, coming back by the Amazon. He discovered and described several species. The specimens collected by Castelnau present at the Museum of Zoology include mainly birds and fishes. One of the fish specimens is labelled as Chrysophrys nasutus type and is probably the (holo)type specimen for Cymatoceps nasutus. The fish specimens were accompanied by five original watercolour notebooks, showing coloured fish-drawings made by the collector at the catch moment. Despite the fact that some of the paintings were used in the past to restore the colours of the naturalised fishes, further research on the relations between the collection and the notebooks should be made. [less ▲]

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See detailLa mise en état des causes sur la base de l'article 4 du titre préliminaire du Code de procédure pénale
Michiels, Olivier ULg

in Jurisprudence de Liège, Mons et Bruxelles (JLMB) (2006)

L'article est publié sous un jugement pronconé par le tribunal de police de Nivelles. Il donne l'occasion à l'auteur de rappeler, en quelques points, la procédure de la mise en état des intérêts civils ... [more ▼]

L'article est publié sous un jugement pronconé par le tribunal de police de Nivelles. Il donne l'occasion à l'auteur de rappeler, en quelques points, la procédure de la mise en état des intérêts civils telle qu'elle est organisée par le nouvel article 4 du titre préliminaire du code de procédure pénale. [less ▲]

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See detailNotice sur le CEDOPAL
Marganne, Marie-Hélène ULg

in Warmembol, E. (Ed.) La Caravane du Caire. L'Égypte sur d'autres rives (2006)

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See detailFour-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity
Cruyssen, B. V.; Van Looy, S.; Wyns, B. et al

in Arthritis Research & Therapy (2006), 8(4), 112

Although there is strong evidence supporting the short-term efficacy and safety of anti-tumour necrosis factor-alpha agents, few studies have examined the long-term effects. We evaluated 511 patients with ... [more ▼]

Although there is strong evidence supporting the short-term efficacy and safety of anti-tumour necrosis factor-alpha agents, few studies have examined the long-term effects. We evaluated 511 patients with long-standing refractory rheumatoid arthritis treated with intravenous infusions of infliximab 3 mg/kg at weeks 0, 2, 6, and 14 and every 8 weeks thereafter for 4 years. Among the initial 511 patients included in the study, 479 could be evaluated; of these, 295 (61.6%) were still receiving infliximab treatment at year 4 of follow-up. The most common reasons for treatment discontinuation were lack of efficacy (65 patients, 13.6%), safety (81 patients, 16.9%), and elective change (38 patients, 7.9%). Analysis of disease activity scores (DAS28 [ disease activity score based on the 28-joint count]) over time showed that, after the initial rapid improvement during the first 6 to 22 weeks of therapy, a further decrease in disease activity of 0.2 units in the DAS28 score per year was observed. DAS28 scores, measured at week 14 or 22, were found to predict subsequent discontinuation due to lack of efficacy. In conclusion, long-term maintenance therapy with infliximab 3 mg/kg is effective in producing further reductions in disease activity. Disease activity measured by the DAS28 at week 14 or 22 of infliximab therapy was the best predictor of long-term attrition. [less ▲]

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See detailp27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex.
Nguyen, Laurent ULg; Besson, Arnaud; Heng, Julian Ik-Tsen et al

in Genes & Development (2006), 20(11), 1511-24

The generation of neurons by progenitor cells involves the tight coordination of multiple cellular activities, including cell cycle exit, initiation of neuronal differentiation, and cell migration. The ... [more ▼]

The generation of neurons by progenitor cells involves the tight coordination of multiple cellular activities, including cell cycle exit, initiation of neuronal differentiation, and cell migration. The mechanisms that integrate these different events into a coherent developmental program are not well understood. Here we show that the cyclin-dependent kinase inhibitor p27(Kip1) plays an important role in neurogenesis in the mouse cerebral cortex by promoting the differentiation and radial migration of cortical projection neurons. Importantly, these two functions of p27(Kip1) involve distinct activities, which are independent of its role in cell cycle regulation. p27(Kip1) promotes neuronal differentiation by stabilizing Neurogenin2 protein, an activity carried by the N-terminal half of the protein. p27(Kip1) promotes neuronal migration by blocking RhoA signaling, an activity that resides in its C-terminal half. Thus, p27(Kip1) plays a key role in cortical development, acting as a modular protein that independently regulates and couples multiple cellular pathways contributing to neurogenesis. [less ▲]

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See detailCoupling cell cycle exit, neuronal differentiation and migration in cortical neurogenesis.
Nguyen, Laurent ULg; Besson, Arnaud; Roberts, James M et al

in Cell Cycle (Georgetown, Tex.) (2006), 5(20), 2314-8

The generation of new neurons in the cerebral cortex requires that progenitor cells leave the cell cycle and activate specific programs of differentiation and migration. Genetic studies have identified ... [more ▼]

The generation of new neurons in the cerebral cortex requires that progenitor cells leave the cell cycle and activate specific programs of differentiation and migration. Genetic studies have identified some of the molecules controlling these cellular events, but how the different aspects of neurogenesis are integrated into a coherent developmental program remains unclear. One possible mechanism implicates multifunctional proteins that regulate, both cell cycle exit and cell differentiation.(1) A prime example is the cyclin-dependent kinase inhibitor p27(Kip1), which has recently been shown to function beyond cell cycle regulation and promote both neuronal differentiation and migration of newborn cortical neurons, through distinct and separable mechanisms. p27(Kip1) is therefore part of a machinery that couples the multiple events of neurogenesis in the cerebral cortex. [less ▲]

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See detailProneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.
Castro, Diogo S; Skowronska-Krawczyk, Dorota; Armant, Olivier et al

in Developmental Cell (2006), 11(6), 831-44

Proneural proteins play a central role in vertebrate neurogenesis, but little is known of the genes that they regulate and of the factors that interact with proneural proteins to activate a neurogenic ... [more ▼]

Proneural proteins play a central role in vertebrate neurogenesis, but little is known of the genes that they regulate and of the factors that interact with proneural proteins to activate a neurogenic program. Here, we demonstrate that the proneural protein Mash1 and the POU proteins Brn1 and Brn2 interact on the promoter of the Notch ligand Delta1 and synergistically activate Delta1 transcription, a key step in neurogenesis. Overexpression experiments in vivo indicate that Brn2, like Mash1, regulates additional aspects of neurogenesis, including the division of progenitors and the differentiation and migration of neurons. We identify by in silico screening a number of additional candidate target genes, which are recognized by Mash1 and Brn proteins through a DNA-binding motif similar to that found in the Delta1 gene and present a broad range of activities. We thus propose that Mash1 synergizes with Brn factors to regulate multiple steps of neurogenesis. [less ▲]

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See detailA role for proneural genes in the maturation of cortical progenitor cells.
Britz, Olivier; Mattar, Pierre; Nguyen, Laurent ULg et al

in Cerebral Cortex (2006), 16 Suppl 1

We showed previously that the proneural genes Neurogenin1 (Ngn1) and Ngn2 are required to specify the phenotypes of early- and not late-born neurons in the neocortex, acting in part through repression of ... [more ▼]

We showed previously that the proneural genes Neurogenin1 (Ngn1) and Ngn2 are required to specify the phenotypes of early- and not late-born neurons in the neocortex, acting in part through repression of Mash1, a third cortically expressed proneural gene. The precise timing of Ngn1/2 specification activity was unexpected given these genes are expressed throughout cortical development, prompting us to search for a later function. Here we reveal that Ngn2 and Mash1 are expressed in a dynamic fashion, acquiring a cell cycle-biased, nonoverlapping distribution, with preferential expression in prospective basal progenitors, during mid corticogenesis. We also identified a new function for Ngn2 during this latter period, demonstrating that it is required to regulate the transit of cortical progenitors from the ventricular zone (VZ) to the subventricular zone. Notably, Ngn2 regulates progenitor maturation at least in part through repression of Mash1 as misexpression of Mash1 strongly enhanced progenitor cell exit from the VZ. Significantly, the ability of Mash1 to promote progenitor cell maturation occurred independently of its ability to respecify cortical cells and is thus a novel function for Mash1. Taken together, these data support a model whereby Ngn2 and Mash1 function together to regulate the zonal distribution of progenitors in the developing neocortex. [less ▲]

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See detailL'Adieu aux Zapara
Bilhaut, Anne-Gaël ULg

in Erikson, Philippe (Ed.) La pirogue ivre : Bières traditionnelles en Amazonie (2006)

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See detailInternational Migration and Its Regulation
Gsir, Sonia ULg; Baganha, Maria; Doomernik, Jeroen et al

in Penninx, Rinus; Berger, Maria; Kraal, Karen (Eds.) The Dynamics of International Migration and Settlement in Europe. A State of the Art. (2006)

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See detailOn the definition and use of landscape metrics to disentangle landscape complexity.
Bogaert, Jan ULg

in Gibelli, G.; Brancucci, G. (Eds.) Pianificare l’Incertezza. L’Ecologia del Paesaggio nella Gestione dei Sistemi Territoriali. (2006)

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