References of "2006"
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See detailObservations
Lecocq, Pascale ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (2006), (mars-avril), 132-133

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See detailNifedipine nanocrystals: pharmacokinetic evaluation in the rat and permeability studies in Caco-2/HT29-5M21 (co)-cultures
Hecq, Julien; Nollevaux, Géraldine; Deleers, M. et al

in Journal of Drug Delivery Science and Technology (2006), 16(6, NOV-DEC), 437-442

Poorly water-soluble drugs such as nifedipine (NIF) (similar to 20 mu g/mL) offer challenging problems in drug formulation as poor solubility is generally associated with poor dissolution characteristics ... [more ▼]

Poorly water-soluble drugs such as nifedipine (NIF) (similar to 20 mu g/mL) offer challenging problems in drug formulation as poor solubility is generally associated with poor dissolution characteristics and thus with poor oral bioavailability (BCS class H drugs). In order to enhance these characteristics, formulation of NIF as nanocrystals was carried out. NIF nanoparticles (NP) were prepared using high-pressure homogenization (HPH). Solubility and dissolution characteristics have been reported in previous work to be significantly enhanced for NIF NP. Influence of NIF particle size on NIF permeation rate across intestinal cell models (Caco-2 and HT29-5M21 cultures and co-cultures) was investigated in order to complement these promising in vitro data. Apical to basolateral transfer studies were carried out across Caco-2 and HT29-5M21 cultures and co-cultures. Caco-2/HT29-5M21 co-cultures (seeding ratio 3: 1) were evaluated to better represent in vivo intestinal conditions. The influence of chitosan in the NIF NP formulation with regard to in vitro NIF permeation rate was also evaluated. These studies showed that NIF permeation rate across the different in vitro models evaluated can be significantly enhanced (approximate to 6-fold) by formulation of NIF as nanoparticles. No significant difference was observed either in the presence of chitosan in the formulation or between the three cell models evaluated. To complement these observations, preliminary in vivo pharmacokinetic evaluations in Sprague-Dawley rats, in the fed and fasted states, were also carried out for both un-milled NIF and NIF NP. [less ▲]

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See detailDifferential effects of hypoxia on étoposide induced apoptosis according to the cancer cell lines
Cosse, Jean-Philippe ULg; Sermeus, Audrey; Vannuvel, Kayleen et al

Poster (2006)

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See detailPourquoi et comment informer le patient lombalgique ?
Bazin, T.; Henrotin, Yves ULg; Cedraschi, C. et al

in Réflexions rhumatologiques (2006), 10(3), 32-35

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See detailEU policy applied to the Walloon region
Burny, Philippe ULg

Conference (2006)

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See detailLes engrais enrichis en sélénium: une alternative pour améliorer le statut en sélénium du bovin
Cabaraux, Jean-François ULg; Dotreppe, Olivier ULg; Hornick, Jean-Luc ULg et al

Article for general public (2006)

Le Sélénium (Se) est un oligo-élément indispensable au bon fonctionnement de l'organisme, notamment chez le bovin. Différents éléments plaident pour l’existence de déficits en Se dans le cheptel bovin et ... [more ▼]

Le Sélénium (Se) est un oligo-élément indispensable au bon fonctionnement de l'organisme, notamment chez le bovin. Différents éléments plaident pour l’existence de déficits en Se dans le cheptel bovin et particulièrement dans les troupeaux allaitants. Solutions injectables, bolus, supplémentation des rations… différentes méthodes permettent d’assurer un statut en Se correct chez l’animal. Une autre alternative consiste à enrichir les aliments produits au niveau de l’exploitation en utilisant des engrais enrichis en Se. Le Service de Nutrition de la Faculté de Médecine Vétérinaire a testé l’effet de ce type d’engrais sur la teneur en Se dans les aliments produits et sur le statut Se d’un troupeau de vaches allaitantes [less ▲]

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See detailPar-dessus le marché. Approche socio-anthropologique de la critique sociale ordinaire en Tunisie
Grenade, Sophie ULg

Master of advanced studies dissertation (2006)

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See detailProcessus d'évaluation des enseignements par les étudiants
Detroz, Pascal ULg; Mainferme, Renaud; Hauzoule, Manu

Scientific conference (2006)

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See detailMieux mesurer l'arthrose.
Henrotin, Yves ULg

Article for general public (2006)

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See detailPrevalence of diabetes, metabolic syndrome and metabolic abnormalities in schizophrenia over the course of the illness: a cross-sectional study.
De Hert, M.; van Winkel, R.; Van Eyck, D. et al

in Clinical Practice and Epidemiology in Mental Health (2006), 2

BACKGROUND: Patients with schizophrenia are at high risk of developing metabolic abnormalities. METHOD: A prospective study focusing on metabolic disturbances in patients with schizophrenia, including an ... [more ▼]

BACKGROUND: Patients with schizophrenia are at high risk of developing metabolic abnormalities. METHOD: A prospective study focusing on metabolic disturbances in patients with schizophrenia, including an oral glucose tolerance test, is currently ongoing at our University Hospital and affiliate services. The prevalence of metabolic abnormalities at baseline was assessed in a cohort of 415 patients with schizophrenia. The sample was divided into 4 groups according to duration of illness: first-episode patients (<1.5 years), recent-onset patients (between 1.5 and 10 years), subchronic patients (between 10 and 20 years) and chronic patients (>20 years). RESULTS: Metabolic abnormalities were already present in first-episode patients, and considerably increased with increasing duration of illness. When compared to the general population matched for age and gender, much higher rates of the metabolic syndrome (MetS) and diabetes were observed for patients with schizophrenia. For MetS, the increase over time was similar to that of the general population. In contrast, the difference in the prevalence of diabetes in patients with schizophrenia and the general population dramatically and linearly increased from 1.6% in the 15-25 age-band to 19.2% in the 55-65 age-band. CONCLUSION: Thus, the current data suggest that on the one hand metabolic abnormalities are an inherent part of schizophrenic illness, as they are already present in first-episode patients. On the other hand, however, our results suggest a direct effect of the illness and/or antipsychotic medication on their occurrence. The data underscore the need for screening for metabolic abnormalities in patients diagnosed with schizophrenia, already starting from the onset of the illness. [less ▲]

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See detailTransfert d’une méthode de dosage automatisée de 3 catécholamines majeures dans l’urine humaine
Rozet, Eric ULg; Dewe, W.; Morello, R. et al

Poster (2006)

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See detailParasites and the island syndrome: the colonization of the western Mediterranean islands by Heligmosomoides polygyrus (Dujardin, 1845)
Nieberding, Caroline M. ULg; Morand, S.; Libois, Roland ULg et al

in Journal of Biogeography (2006), 33(7), 1212-1222

Aim Populations of free-living vertebrates on islands frequently differ from their mainland counterparts by a series of changes in morphometric, life-history, behavioural, physiological and genetic traits ... [more ▼]

Aim Populations of free-living vertebrates on islands frequently differ from their mainland counterparts by a series of changes in morphometric, life-history, behavioural, physiological and genetic traits, collectively referred to as the 'island syndrome'. It is not known, however, whether the 'island syndrome' also affects parasitic organisms. The present study establishes the colonization pattern of the Mediterranean islands by the nematode Heligmosomoides polygyrus, a direct and specific parasite of rodent hosts of the Apodemus genus, and evaluates the effects of island colonization by this species on two components of the island syndrome: the loss of genetic diversity and the enlargement of the ecological niche. Location Heligmosomoides polygyrus was sampled on seven western Mediterranean islands - Corsica, Crete, Elba, Majorca, Minorca, Sardinia and Sicily - as well as in 20 continental locations covering the Mediterranean basin. Methods The mitochondrial cytochrome b gene (690 base pairs) was sequenced in 166 adult H. polygyrus individuals sampled in the 27 continental and island locations. Phylogenetic reconstructions in distance, parsimony, maximum likelihood and Bayesian posterior probabilities were carried out on the whole cytochrome b gene data set. The levels of nucleotide, haplotype and genetic divergence (Kimura two-parameter distance estimator) diversities were estimated in each island population and in the various continental lineages. Results Phylogenetic reconstructions show that the mainland origins of H. polygyrus were continental Spain for the Balearic Islands (Majorca, Minorca), northern Italy for the Tyrrhenian Islands (Corsica, Sardinia, Elba), southern Italy for Sicily, and the Balkan region for Crete. A comparison of island H. polygyrus populations with their mainland source populations revealed two characteristic components of the island syndrome in this parasite. First, island H. polygyrus populations display a significant loss of genetic diversity, which is related (r(2) = 0.73) to the distance separating the island from the mainland source region. Second, H. polygyrus exhibits a niche enlargement following insularization. Indeed, H. polygyrus in Corsica is present in both A. sylvaticus and Mus musculus domesticus, while mainland H. polygyrus populations are present exclusively in Apodemus hosts. Main conclusions Our results show that H. polygyrus has undergone a loss of genetic diversity and a niche (host) enlargement following colonization of the western Mediterranean islands. To our knowledge, this study provides the first evidence for components of the 'island syndrome' in a parasitic nematode species. [less ▲]

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See detailContribution to the study of camel milk fat globule membrane
Karray, Nadia Laadhar; Danthine, Sabine ULg; Blecker, Christophe ULg et al

in International Journal of Food Sciences & Nutrition (2006), 57(5-6), 382-390

The camel milk fat globule membrane has been characterized according to several approaches. Compared with the cow milk fat globule membrane, various specificities have been revealed. Its physicochemical ... [more ▼]

The camel milk fat globule membrane has been characterized according to several approaches. Compared with the cow milk fat globule membrane, various specificities have been revealed. Its physicochemical composition showed a poor content in proteins, and a higher content in neutral lipids and in phospholipids. The mechanical properties measured at low (4 degrees C, 20 degrees C) and high temperatures (40 degrees C, 45 degrees C and 50 degrees C) using a film balance are different when the camel milk fat globule membrane is spread at the air-water interface. The thermal study revealed an important proportion of high-melting triacylglycerols that involves fatty acids with long chains. [less ▲]

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See detailWork Spaces in Art, Science and Business
Froehlicher, Thomas ULg; Joly, Jean-Baptiste; Billier, Dominique

Book published by Merz&Solitude Reihe Reflexiv (2006)

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See detailSome Concerns About the Reliability of LTE Abundance Analyses in Cool, Active Stars
Morel, Thierry ULg; Micela, G.; Favata, F.

in Chemical Abundances and Mixing in Stars in the Milky Way and its Satellites, ESO ASTROPHYSICS SYMPOSIA. ISBN 978-3-540-34135-2. Springer-Verlag, 2006, p. 64 (2006)

We discuss recent observational evidence illustrating the current limitations plaguing classical LTE abundance analyses of cool (T [SUB]eff[/SUB] < 5500 K), chromospherically active stars. Although ... [more ▼]

We discuss recent observational evidence illustrating the current limitations plaguing classical LTE abundance analyses of cool (T [SUB]eff[/SUB] < 5500 K), chromospherically active stars. Although significant progress on this issue can be evidently expected from a more realistic atmospheric modelling and treatment of NLTE line formation, a homogeneous abundance study of a large sample of inactive K-type stars may also prove valuable in disentangling temperature and activity effects. [less ▲]

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