References of "2006"
     in
Bookmark and Share    
Peer Reviewed
See detailNumerical simulation in cold rolling using adiabatic strip model : application to large roll deformation
STEPHANY, A.; Ponthot, Jean-Philippe ULg; LEGRAND, N.

in AUSTRIB 06 (2006)

Detailed reference viewed: 21 (3 ULg)
Full Text
Peer Reviewed
See detailBind another day: the LFA-1/ICAM-1 interation as therapeutic target
Zecchinon, Laurent ULg; Fett, Thomas ULg; Vanden Bergh, Philippe ULg et al

in Clinical & Applied Immunology Reviews (2006), 6

Detailed reference viewed: 15 (4 ULg)
Full Text
Peer Reviewed
See detailL’effet de l’atmosphère terrestre sur les GNSS : une perturbation ou un signal géophysique ?
Warnant, René ULg

in Bulletin de la Société Géographique de Liège (2006), 47

Detailed reference viewed: 17 (4 ULg)
Full Text
Peer Reviewed
See detailDegré d'atteinte nerveuse périphérique dans la SLA, la SLP et la maladie de Kennedy
WANG, François-Charles ULg; Le Forestier, Nadine; GERARD, Pascale ULg et al

in Neurophysiologie Clinique = Clinical Neurophysiology (2006)

Detailed reference viewed: 20 (2 ULg)
Full Text
Peer Reviewed
See detailNifedipine nanocrystals: pharmacokinetic evaluation in the rat and permeability studies in Caco-2/HT29-5M21 (co)-cultures
Hecq, Julien; Nollevaux, Géraldine; Deleers, M. et al

in Journal of Drug Delivery Science and Technology (2006), 16(6, NOV-DEC), 437-442

Poorly water-soluble drugs such as nifedipine (NIF) (similar to 20 mu g/mL) offer challenging problems in drug formulation as poor solubility is generally associated with poor dissolution characteristics ... [more ▼]

Poorly water-soluble drugs such as nifedipine (NIF) (similar to 20 mu g/mL) offer challenging problems in drug formulation as poor solubility is generally associated with poor dissolution characteristics and thus with poor oral bioavailability (BCS class H drugs). In order to enhance these characteristics, formulation of NIF as nanocrystals was carried out. NIF nanoparticles (NP) were prepared using high-pressure homogenization (HPH). Solubility and dissolution characteristics have been reported in previous work to be significantly enhanced for NIF NP. Influence of NIF particle size on NIF permeation rate across intestinal cell models (Caco-2 and HT29-5M21 cultures and co-cultures) was investigated in order to complement these promising in vitro data. Apical to basolateral transfer studies were carried out across Caco-2 and HT29-5M21 cultures and co-cultures. Caco-2/HT29-5M21 co-cultures (seeding ratio 3: 1) were evaluated to better represent in vivo intestinal conditions. The influence of chitosan in the NIF NP formulation with regard to in vitro NIF permeation rate was also evaluated. These studies showed that NIF permeation rate across the different in vitro models evaluated can be significantly enhanced (approximate to 6-fold) by formulation of NIF as nanoparticles. No significant difference was observed either in the presence of chitosan in the formulation or between the three cell models evaluated. To complement these observations, preliminary in vivo pharmacokinetic evaluations in Sprague-Dawley rats, in the fed and fasted states, were also carried out for both un-milled NIF and NIF NP. [less ▲]

Detailed reference viewed: 161 (30 ULg)
See detailPar-dessus le marché. Approche socio-anthropologique de la critique sociale ordinaire en Tunisie
Grenade, Sophie ULg

Master of advanced studies dissertation (2006)

Detailed reference viewed: 21 (4 ULg)
Full Text
Peer Reviewed
See detailAntiviral efficacy and resistance in patients on antiretroviral therapy in Kigali, Rwanda: the real-life situation in 2002.
Fischer, A; Karasi, Jean Claude ULg; Kibibi, D et al

in HIV Medicine (2006), 7(1), 64-6

Our study aimed to complete the published data on ARV therapy in Africa by describing the baseline situation in Rwanda before the launch of a large ARV programme (ESTHER). Prescription habits, frequency ... [more ▼]

Our study aimed to complete the published data on ARV therapy in Africa by describing the baseline situation in Rwanda before the launch of a large ARV programme (ESTHER). Prescription habits, frequency and reasons for treatment interruptions but also antiviral efficay, resistance to ARVs and genotypic variability of the viruses present in Rwanda were analysed. Among the 233 patients included in the study, it appeared that a vast majority (91%) were under triple therapy and that half of them had experienced at least one treatment interruption caused mainly by drug shortage or financial difficulties. Among 60 blood samples analysed, 26 were in virological failure with a viral load above 1000 RNA copies/ml and 11 presented major drug resistance mutations. Finally, virological failure could mainly be explained by the high frequency of treatment interruptions but also by the emergence of drug resistance mutations. Consequently the major objective for the ESTHER programme to improve the situation in Rwanda will be to reduce the drug shortage and facilitate the financial accessibility of the treatments. [less ▲]

Detailed reference viewed: 8 (5 ULg)
Full Text
Peer Reviewed
See detailTraitements médicaux du système respiratoire: 2-broncho-dilatateurs et autres substances
Van Erck, Emmanuelle ULg; Art, Tatiana ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (2006), 38

The medical therapeutic arsenal available to the practitioner for treatment of respiratory conditions in horses is growing because of new drugs being introduced on the market, the marketing authorisation ... [more ▼]

The medical therapeutic arsenal available to the practitioner for treatment of respiratory conditions in horses is growing because of new drugs being introduced on the market, the marketing authorisation obtained for certain existing active ngredients, the possibility of using medicines authorised for humans and the development of aerosoltherapy. Nevertheless treatment remains empirical in the absence of a precise diagnosis, and the use of particular medicines may be unjustified and even erroneous, and in addition treatment fa ures can be discouraging and costly for the owner. However, when the diagnosis is established, combination of several medicines can silmificaxrtly and rapidly improve clinical signs and/or performance, and avoid sequelae and recurrence. In this article brief information is given on management of the environment followed by a very complete list of medicines used in horses with respirrtory conditions. The différent active ingredients available are listed by category and these includé antimicrobials, anti-inflammatories, bronchodilatators, mucolytics immune stimulants and other substances. Dosages, indications, pharmacokinetic properties, possible secondary effects and contra-indications are complied from a avide literature review. The essential considerations when deciding which treatment to use are discussed, in particular the effectiveness of the treatment for the disease, the mode of administration and the potential cost [less ▲]

Detailed reference viewed: 90 (14 ULg)
Full Text
Peer Reviewed
See detailProlactin/growth hormone-derived antiangiogenic peptides highlight a potential role of tilted peptides in angiogenesis
Nguyen, Ngoc-Quynh-Nhu ULg; Tabruyn, Sébastien ULg; Lins, Laurence ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2006), 103(39), 14319-14324

Angiogenesis is a crucial step in many pathologies, including tumor growth and metastasis. Here, we show that tilted peptides exert antiangiogenic activity. Tilted (or oblique-oriented) peptides are short ... [more ▼]

Angiogenesis is a crucial step in many pathologies, including tumor growth and metastasis. Here, we show that tilted peptides exert antiangiogenic activity. Tilted (or oblique-oriented) peptides are short peptides known to destabilize membranes and lipid cores and characterized by an asymmetric distribution of hydrophobic residues along the axis when helical. We have previously shown that 16-kDa fragments of the human prolactin/growth hormone (PRL/GH) family members are potent angiogenesis inhibitors. Here, we demonstrate that all these fragments possess a 14-aa sequence having the characteristics of a tilted peptide. The tilted peptides of human prolactin and human growth hormone induce endothelial cell apoptosis, inhibit endothelial cell proliferation, and inhibit capillary formation both in vitro and in vivo. These antiangiogenic effects are abolished when the peptides' hydrophobicity gradient is altered by mutation. We further demonstrate that the well known tilted peptides of simian immunodeficiency virus gp32 and Alzheimer's beta-amyloid peptide are also angiogenesis inhibitors. Taken together, these results point to a potential new role for tilted peptides in regulating angiogenesis. [less ▲]

Detailed reference viewed: 99 (23 ULg)
Full Text
Peer Reviewed
See detailOutils technologiques pour gérer la qualité microbiologique des aliments
Clinquart, Antoine ULg

in Belgian Association for Meat Science and Technology (Ed.) Journée d’étude MICROBIOLOGIE ET VIANDE : QUE FAIRE DEMAIN ? (2006)

Même si elles peuvent contribuer de manière très spectaculaire à la maîtrise de la qualité microbiologique des aliments, les techniques de conservation elles-mêmes ne sont pourtant qu’un moyen de maîtrise ... [more ▼]

Même si elles peuvent contribuer de manière très spectaculaire à la maîtrise de la qualité microbiologique des aliments, les techniques de conservation elles-mêmes ne sont pourtant qu’un moyen de maîtrise parmi d’autres… Deux facteurs principaux sont tout simplement la qualité initiale –en particulier la qualité microbiologique- des aliments ou des ingrédients qui les constituent et l’hygiène observée au cours de leur production, de leur transformation et de leur distribution. De plus, un effet « obstacle » n’est reproductible que dans des conditions précises, par exemple pour ce qui concerne le nombre de microorganismes, la composition de l’aliment, les conditions d’ambiance, etc… Une technique de conservation doit donc être validée dans des conditions données (p.ex. par validation de la durée de vie microbiologique permettant d’estimer la D.L.C. d’un produit). Toute modification de ces conditions ne permet plus de garantir la maîtrise de la qualité microbiologique. Il convient par ailleurs d’évaluer l’effet d’une contamination accidentelle de la denrée par un microorganisme pathogène, au cours de sa production, de sa transformation ou de sa distribution (test de croissance après inoculation artificielle de la denrée, encore appelé « challenge testing »). L’établissement et le respect de critères microbiologiques, de bonnes pratiques de fabrication et de procédures d’assurance qualité sont des points clés de la maîtrise de la qualité et de la sécurité sanitaire des aliments. Des progrès significatifs sont en cours et sont encore attendus dans les prochaines années. [less ▲]

Detailed reference viewed: 88 (8 ULg)
Full Text
Peer Reviewed
See detailMedecin de famille et intoxication au monoxyde de carbone
Burette, Philippe ULg; Bouüaert, Corine ULg; Vanmeerbeek, Marc ULg et al

in Revue Médicale de Liège (2006), 61(5-6, May-Jun), 285-90

Carbon monoxide poisoning is not easily identifiable. It is the first cause of death by accidental poisoning in Europe. The family practitioner, who has not been made aware of this problem, incurs the ... [more ▼]

Carbon monoxide poisoning is not easily identifiable. It is the first cause of death by accidental poisoning in Europe. The family practitioner, who has not been made aware of this problem, incurs the risk of diagnostic indecision or of involuntary personal poisoning. Since symptomatology is non specific, the general practitioner answering housecalls is sometimes confronted with an urgent medical problem linked to the complications of this intoxication (coronary, neurological problems...), without having ways of documenting its origin of the poisoning or any means to protect himself. Through direct contact with his patients' environment, the family practitioner, being made sensitive to this problem, can certainly contribute to care and aftercare of the patient suffering from carbon monoxide poisoning, but also to the prevention of this public health problem often called "the silent killer". [less ▲]

Detailed reference viewed: 165 (12 ULg)
See detailL'Adieu aux Zapara
Bilhaut, Anne-Gaël ULg

in Erikson, Philippe (Ed.) La pirogue ivre : Bières traditionnelles en Amazonie (2006)

Detailed reference viewed: 21 (0 ULg)