References of "2006"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailCoupling cell cycle exit, neuronal differentiation and migration in cortical neurogenesis.
Nguyen, Laurent ULg; Besson, Arnaud; Roberts, James M et al

in Cell Cycle (Georgetown, Tex.) (2006), 5(20), 2314-8

The generation of new neurons in the cerebral cortex requires that progenitor cells leave the cell cycle and activate specific programs of differentiation and migration. Genetic studies have identified ... [more ▼]

The generation of new neurons in the cerebral cortex requires that progenitor cells leave the cell cycle and activate specific programs of differentiation and migration. Genetic studies have identified some of the molecules controlling these cellular events, but how the different aspects of neurogenesis are integrated into a coherent developmental program remains unclear. One possible mechanism implicates multifunctional proteins that regulate, both cell cycle exit and cell differentiation.(1) A prime example is the cyclin-dependent kinase inhibitor p27(Kip1), which has recently been shown to function beyond cell cycle regulation and promote both neuronal differentiation and migration of newborn cortical neurons, through distinct and separable mechanisms. p27(Kip1) is therefore part of a machinery that couples the multiple events of neurogenesis in the cerebral cortex. [less ▲]

Detailed reference viewed: 41 (1 ULg)
Full Text
Peer Reviewed
See detailProneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.
Castro, Diogo S; Skowronska-Krawczyk, Dorota; Armant, Olivier et al

in Developmental Cell (2006), 11(6), 831-44

Proneural proteins play a central role in vertebrate neurogenesis, but little is known of the genes that they regulate and of the factors that interact with proneural proteins to activate a neurogenic ... [more ▼]

Proneural proteins play a central role in vertebrate neurogenesis, but little is known of the genes that they regulate and of the factors that interact with proneural proteins to activate a neurogenic program. Here, we demonstrate that the proneural protein Mash1 and the POU proteins Brn1 and Brn2 interact on the promoter of the Notch ligand Delta1 and synergistically activate Delta1 transcription, a key step in neurogenesis. Overexpression experiments in vivo indicate that Brn2, like Mash1, regulates additional aspects of neurogenesis, including the division of progenitors and the differentiation and migration of neurons. We identify by in silico screening a number of additional candidate target genes, which are recognized by Mash1 and Brn proteins through a DNA-binding motif similar to that found in the Delta1 gene and present a broad range of activities. We thus propose that Mash1 synergizes with Brn factors to regulate multiple steps of neurogenesis. [less ▲]

Detailed reference viewed: 51 (6 ULg)
Full Text
Peer Reviewed
See detailA role for proneural genes in the maturation of cortical progenitor cells.
Britz, Olivier; Mattar, Pierre; Nguyen, Laurent ULg et al

in Cerebral Cortex (2006), 16 Suppl 1

We showed previously that the proneural genes Neurogenin1 (Ngn1) and Ngn2 are required to specify the phenotypes of early- and not late-born neurons in the neocortex, acting in part through repression of ... [more ▼]

We showed previously that the proneural genes Neurogenin1 (Ngn1) and Ngn2 are required to specify the phenotypes of early- and not late-born neurons in the neocortex, acting in part through repression of Mash1, a third cortically expressed proneural gene. The precise timing of Ngn1/2 specification activity was unexpected given these genes are expressed throughout cortical development, prompting us to search for a later function. Here we reveal that Ngn2 and Mash1 are expressed in a dynamic fashion, acquiring a cell cycle-biased, nonoverlapping distribution, with preferential expression in prospective basal progenitors, during mid corticogenesis. We also identified a new function for Ngn2 during this latter period, demonstrating that it is required to regulate the transit of cortical progenitors from the ventricular zone (VZ) to the subventricular zone. Notably, Ngn2 regulates progenitor maturation at least in part through repression of Mash1 as misexpression of Mash1 strongly enhanced progenitor cell exit from the VZ. Significantly, the ability of Mash1 to promote progenitor cell maturation occurred independently of its ability to respecify cortical cells and is thus a novel function for Mash1. Taken together, these data support a model whereby Ngn2 and Mash1 function together to regulate the zonal distribution of progenitors in the developing neocortex. [less ▲]

Detailed reference viewed: 20 (3 ULg)
Full Text
Peer Reviewed
See detailEffect of diazepam on the efficacy of dual-phase FDG PET imaging.
Zhuang, Hongming; Hustinx, Roland ULg; Alavi, Abass

in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(2), 228-9230

Detailed reference viewed: 24 (2 ULg)
Full Text
Peer Reviewed
See detailDespite inhibition of hematopoietic progenitor cell growth in vitro, the tyrosine kinase inhibitor imatinib does not impair engraftment of human CD133+ cells into NOD/SCIDbeta2mNull mice.
Pirson, Laurence ULg; Baron, Frédéric ULg; Meuris, Nathalie ULg et al

in Stem Cells (2006), 24(7), 1814-21

There is potential interest for combining allogeneic hematopoietic cell transplantation (HCT), and particularly allogeneic HCT with a nonmyeloablative regimen, to the tyrosine kinase inhibitor imatinib ... [more ▼]

There is potential interest for combining allogeneic hematopoietic cell transplantation (HCT), and particularly allogeneic HCT with a nonmyeloablative regimen, to the tyrosine kinase inhibitor imatinib (Glivec; Novartis, Basel, Switzerland, http://www.novartis.com) in order to maximize anti-leukemic activity against Philadelphia chromosome-positive leukemias. However, because imatinib inhibits c-kit, the stem cell factor receptor, it could interfere with bone marrow engraftment. In this study, we examined the impact of imatinib on normal progenitor cell function. Imatinib decreased the colony-forming capacity of mobilized peripheral blood human CD133(+) cells but not that of long-term culture-initiating cells. Imatinib also decreased the proliferation of cytokine-stimulated CD133(+) cells but did not induce apoptosis of these cells. Expression of very late antigen (VLA)-4, VLA-5, and CXCR4 of CD133(+) cells was not modified by imatinib, but imatinib decreased the ability of CD133(+) cells to migrate. Finally, imatinib did not decrease engraftment of CD133(+) cells into irradiated nonobese diabetic/severe combined immunodeficient/beta2m(null) mice conditioned with 3 or 1 Gy total body irradiation. In summary, our results suggest that, despite inhibition of hematopoietic progenitor cell growth in vitro, imatinib does not interfere with hematopoietic stem cell engraftment. [less ▲]

Detailed reference viewed: 78 (35 ULg)
See detailHashimoto's Encephalopathy in graves' disease
Tamagno, G.; de Carlo, E.; Beckers, Albert ULg et al

in 23ème Congrès de la Société Française d'Endocrinologie - Abstract book (2006)

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailImpact of the invasive alien plant Solidago giganteaon primary productivity, plant nutrient content and soil mineral nutrient concentrations
Vanderhoeven, SONIA ULg; Dassonville, Nicolas; Chapuis-Lardy, Lydie et al

in Plant and Soil (2006), 286(1-2), 259-268

Invasion by alien plants can alter ecosystem processes and soil properties. In this study, we compared aboveground productivity, nutrient pools in standing biomass and topsoil (0-0.10 m) mineral nutrient ... [more ▼]

Invasion by alien plants can alter ecosystem processes and soil properties. In this study, we compared aboveground productivity, nutrient pools in standing biomass and topsoil (0-0.10 m) mineral nutrient concentrations between plots invaded by Early Goldenrod (Solidago gigantea) and adjacent, uninvaded, vegetation at five sites in Belgium. The five sites were characterised by a resident perennial herbaceous vegetation and spanned a wide range in soil fertility level and floristic composition. Invaded stands consistently had higher (2-3-fold) aboveground productivity and lower mineral element concentrations in standing phytomass. Nutrient pools (calculated as concentration x phytomass) was ca. twice higher in invaded plots, suggesting that S. gigantea might enhance nutrient cycling rates. Impacts on topsoil chemistry were surprisingly modest, with slightly higher nutrient concentrations under the invader. A noticeable exception was phosphorus, which showed higher concentrations of ammonium acetate-extractable fraction in invaded plots in four of five sites. It appears that S. gigantea does not significantly contribute to nutrient uplift from deep soil layers to topsoil, possibly because it does not root much deeper compared to resident vegetation. [less ▲]

Detailed reference viewed: 39 (4 ULg)
Full Text
Peer Reviewed
See detailInfluence du degré de mouture et de l'extrusion sur la valeur nutritionnelle de la graine de lupin
Froidmont, Eric; Bonnet, Maxime; Beckers, Yves ULg et al

in Rencontres autour des Recherches sur les Ruminants (2006), 12

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailPsoriasis et arthrite psoriasique
Henno, Audrey ULg; Rausin, Annick ULg; Malaise, Michel ULg et al

in Revue Médicale de Liège (2006), 61(5-6, May-Jun), 334-340

Psoriasis is a frequent multifactorial chronic skin disease that can lead to a decreased quality of life. Some patients also present arthritis. Those two complex inflammatory diseases share some of their ... [more ▼]

Psoriasis is a frequent multifactorial chronic skin disease that can lead to a decreased quality of life. Some patients also present arthritis. Those two complex inflammatory diseases share some of their characteristics, but several clinical manifestations can be distinguished in each of them. In addition to classical medications (constituted of topical treatments, methotrexate, ciclosporin and retinoids for cutaneous psoriasis and non steroidal anti-inflammatory drugs or methotrexate for psoriatic arthritis), they are the target of a new generation of therapies: the biologics. [less ▲]

Detailed reference viewed: 102 (5 ULg)
Full Text
See detailL’analyse du travail : centrale ou simplement utile ?
De Keyser, Véronique ULg; Nyssen, Anne-Sophie ULg

in Vallery, Gérard; Amalberti, René (Eds.) L’analyse du travail en perspective – Influences et évolutions. (2006)

Detailed reference viewed: 134 (7 ULg)
See detailAURA validation by the baloon-borne MkIV Interferometer.
Toon, G. C.; Kleinboehl, A.; Salawitch, R. J. et al

Scientific conference (2006)

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailRevision of the Belgian Nursing Minimum Dataset: from data to information
SERMEUS, Walter; VAN DEN HEEDE, Koen; MICHIELS, Dominik et al

in Studies in Health Technology & Informatics (2006), 122

The Ministry of Public Health commissioned a research project to the Catholic University of Leuven and the University Hospital of Liege to revise the Belgian Nursing Minimum Dataset (B-NMDS). The study ... [more ▼]

The Ministry of Public Health commissioned a research project to the Catholic University of Leuven and the University Hospital of Liege to revise the Belgian Nursing Minimum Dataset (B-NMDS). The study started in 2000 and will end with the implementation of the revised B-NMDS in January 2007. The study entailed four major phases. The first phase involved the development of a conceptual framework based on a literature review and secondary data analysis. The second phase focused on language development and development of a data collection tool. The third phase focused on data collection and validation of the new tool. In the fourth phase the validity and reliability of the dataset was tested. The new dataset is without avail if it is not leading to new information. Four applications of the dataset has been defined from the beginning: evaluation of the appropriateness of stay (AEP) in the hospital, nurse staffing, hospital financing and quality management. The aim of this paper is to describe how the B-NMDS can contribute to each of these applications. [less ▲]

Detailed reference viewed: 133 (20 ULg)
Full Text
Peer Reviewed
See detailThe 1988-2003 Greenland ice sheet melt extent by passive microwave satellite data and a regional climate model
Fettweis, Xavier ULg; Gallée, Hubert; Lefebre, Filip et al

in Climate Dynamics (2006), 27(5), 531-541

Measurements from ETH-Camp and JAR1 AWS (West Greenland) as well as coupled atmosphere-snow regional climate simulations have highlighted flaws in the cross-polarized gradient ratio (XPGR) technique used ... [more ▼]

Measurements from ETH-Camp and JAR1 AWS (West Greenland) as well as coupled atmosphere-snow regional climate simulations have highlighted flaws in the cross-polarized gradient ratio (XPGR) technique used to identify melt from passive microwave satellite data. It was found that dense clouds (causing notably rainfall) on the ice sheet severely perturb the XPGR melt signal. Therefore, the original XPGR melt detection algorithm has been adapted to better incorporate atmospheric variability over the ice sheet and an updated melt trend for the 1988–2003 period has been calculated. Compared to the original algorithm, the melt zone area increase is eight times higher (from 0.2 to 1.7% year−1). The increase is higher with the improved XPGR technique because rainfall also increased during this period. It is correlated to higher atmospheric temperatures. Finally, the model shows that the total ice sheet runoff is directly proportional to the melt extent surface detected by satellites. These results are important for the understanding of the effect of Greenland melting on the stability of the thermohaline circulation. [less ▲]

Detailed reference viewed: 27 (5 ULg)
Full Text
See detailÉrasme de Rotterdam, Gratulatorius panegyricus ad principem Philippum archiducem austriae
Adam, Renaud ULg

in Bousmanne, Bernard; Thieffry, Sandrine; Wijsman, Hanno (Eds.) Philippe le Beau (1478-1506) : les trésors du dernier duc de Bourgogne : exposition : Bruxelles, Bibliothèque royale de Belqique, Chapelle de Nassau, du 3 novembre 2006 au 27 janvier 2007 : catalogue (2006)

Detailed reference viewed: 27 (0 ULg)
Full Text
Peer Reviewed
See detailIn Search of Novel Ampa Potentiators
Francotte, Pierre ULg; De Tullio, Pascal ULg; Fraikin, Pierre ULg et al

in Recent Patents on CNS Drug Discovery (2006), 1(3), 239-46

Glutamate is the major excitatory neurotransmitter in the brain. Amongst ionotropic receptors responding to glutamate, the AMPA subtype has been considered as essential for the fast excitatory ... [more ▼]

Glutamate is the major excitatory neurotransmitter in the brain. Amongst ionotropic receptors responding to glutamate, the AMPA subtype has been considered as essential for the fast excitatory neurotransmission in the central nervous system and the expression and maintenance of long-term potentiation. As glutamate is known to be involved in many neurological and psychiatric disorders, AMPA receptors seem to represent interesting targets to develop therapeutic drugs. Hence, the enhancement of AMPA signals is an approach currently investigated for the management of Alzheimer's disease, schizophrenia or mood disorders. In particular, many efforts are being conducted in the development of AMPA positive allosteric modulators ("potentiators"), which alter the rate of receptor desensitization. The major chemical families developed as AMPA potentiators are aniracetam derivatives, cyclothiazide derivatives and biarylpropylsulfonamides derivatives. [less ▲]

Detailed reference viewed: 59 (25 ULg)
Peer Reviewed
See detailEen contrast in contrastief taalonderzoek
Hiligsmann, Philippe; Rasier, Laurent ULg

Conference (2006)

Detailed reference viewed: 7 (0 ULg)
Full Text
See detailLarge-scale groundwater flow and transport modelling : Methodology and application to the Geer basin, Belgium
Orban, Philippe ULg; Dassargues, Alain ULg; Brouyère, Serge ULg

in Stauffer, Fr.; Dassargues, Alain (Eds.) Quantitative Geology from Multiple Sources: S10 Use of multiple sources in conditioning/calibrating groundwater flow and transport models (2006)

Efficient and sustainable management of water resources should be considered from an integrated way, at the basin scale. For that purpose, physically-based, spatially distributed modelling tools has ... [more ▼]

Efficient and sustainable management of water resources should be considered from an integrated way, at the basin scale. For that purpose, physically-based, spatially distributed modelling tools has turned to be very useful. If regional groundwater flow model have been developed for years now, large scale contaminant transport models are still almost inexistent. The objective of this extended abstract is to present briefly new concepts for large transport modelling, more particularly a modelling approach, the Hybrid Finite Element Mixing Cell (HFEMC) developed by the Hydrogeology Group of the University of Liège and implemented in the 3D simulator SUFT3D. First steps for the application to the Geer basin are also presented. [less ▲]

Detailed reference viewed: 51 (17 ULg)
Peer Reviewed
See detailPET and PET/CT Imaging in Lung Cancer
Rigo, Pierre ULg; Hustinx, Roland ULg; Bury, Thierry ULg

in Valk, PE; Delbeke, D; Bailey, DL (Eds.) et al Positron Emission Tomography - Clnical practice (2006)

Detailed reference viewed: 13 (1 ULg)