References of "2006"
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See detailErard de La Marck, mécène et collectionneur (1472-1538)
Adam, Renaud ULg

in La vie des musées : bulletin de l'association francophone des musées de Belgique (2006), 20

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See detailA finite element method for poro mechanical modelling of geotechnical problems using local second gradient models
Collin, Frédéric ULg; Chambon, René; Charlier, Robert ULg

in International Journal for Numerical Methods in Engineering (2006), 65(11), 1749-1772

In this paper, a new finite element method is described and applied. It is based on a theory developed to model poromechanical problems where the mechanical part is obeying a second gradient theory. The ... [more ▼]

In this paper, a new finite element method is described and applied. It is based on a theory developed to model poromechanical problems where the mechanical part is obeying a second gradient theory. The aim of such a work is to properly model the post localized behaviour of soils and rocks saturated with a pore fluid. Beside the development of this new Coupled theory, a corresponding finite element method has been developed. The elements used are based on a weak form of the relation between the deformation gradient and the second gradient, using a field of Lagrange multipliers. The global problem is solved by a system of equations where the kinematic variables are fully coupled with the pore pressure. Some numerical experiments showing the effectiveness of the method ends the paper. Copyright (c) 2005 John Wiley [less ▲]

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See detailNifedipine nanocrystals: pharmacokinetic evaluation in the rat and permeability studies in Caco-2/HT29-5M21 (co)-cultures
Hecq, Julien; Nollevaux, Géraldine; Deleers, M. et al

in Journal of Drug Delivery Science and Technology (2006), 16(6, NOV-DEC), 437-442

Poorly water-soluble drugs such as nifedipine (NIF) (similar to 20 mu g/mL) offer challenging problems in drug formulation as poor solubility is generally associated with poor dissolution characteristics ... [more ▼]

Poorly water-soluble drugs such as nifedipine (NIF) (similar to 20 mu g/mL) offer challenging problems in drug formulation as poor solubility is generally associated with poor dissolution characteristics and thus with poor oral bioavailability (BCS class H drugs). In order to enhance these characteristics, formulation of NIF as nanocrystals was carried out. NIF nanoparticles (NP) were prepared using high-pressure homogenization (HPH). Solubility and dissolution characteristics have been reported in previous work to be significantly enhanced for NIF NP. Influence of NIF particle size on NIF permeation rate across intestinal cell models (Caco-2 and HT29-5M21 cultures and co-cultures) was investigated in order to complement these promising in vitro data. Apical to basolateral transfer studies were carried out across Caco-2 and HT29-5M21 cultures and co-cultures. Caco-2/HT29-5M21 co-cultures (seeding ratio 3: 1) were evaluated to better represent in vivo intestinal conditions. The influence of chitosan in the NIF NP formulation with regard to in vitro NIF permeation rate was also evaluated. These studies showed that NIF permeation rate across the different in vitro models evaluated can be significantly enhanced (approximate to 6-fold) by formulation of NIF as nanoparticles. No significant difference was observed either in the presence of chitosan in the formulation or between the three cell models evaluated. To complement these observations, preliminary in vivo pharmacokinetic evaluations in Sprague-Dawley rats, in the fed and fasted states, were also carried out for both un-milled NIF and NIF NP. [less ▲]

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See detailLFA-1 and associated diseases: the dark side of a receptor
Zecchinon, Laurent ULg; Fett, Thomas ULg; Vanden Bergh, Philippe ULg et al

in Clinical & Applied Immunology Reviews (2006), 6

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See detailMAXIMIZATION OF PULL-IN VOLTAGE OF MICRO-ELECTROMECHANICAL STRUCTURES USING TOPOLOGY OPTIMIZATION
Lemaire, Etienne ULg; Rochus, Véronique ULg; Fleury, Claude ULg et al

Conference (2006)

The design problem consists in maximizing the pull-in voltage using topology optimization method, which is formulated as an optimal material distribution. In addition to the classical volume constraint ... [more ▼]

The design problem consists in maximizing the pull-in voltage using topology optimization method, which is formulated as an optimal material distribution. In addition to the classical volume constraint, different structural constraints could be taken into consideration. Sensitivity analysis is one of the key issues of the optimization process and is performed with the formulation of eigenvalue topology optimization problems. Here the paper investigates topology optimization of strongly coupled electromechanical systems. To avoid important modifications of the electric field by the optimization process, this first study considers a non design electrode and use topology optimization to design an optimal suspension structure. Solution procedure of the optimization problem is based on CONLIN optimizer using a sequential convex programming. This method that has proved its efficiency in many structural problems (sizing, shape) is here tailored to strongly coupled multiphysics design problems under consideration. The choice of appropriate explicit convex approximations schemes for multiphysic problems is investigated. The proposed method is illustrated and validated on microbeam optimization applications. [less ▲]

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See detailIdentification of hardening behavior using inverse modeling and image correlation
Lecompte, D.; Cooreman, S.; Sol, H. et al

in Proceedings of the SEM annual conference and exposition 2006 (2006)

The basic principle of an inverse modeling procedure as it is used for parameter identification, is the generation of a complex and heterogeneous deformation field that contains as much information as ... [more ▼]

The basic principle of an inverse modeling procedure as it is used for parameter identification, is the generation of a complex and heterogeneous deformation field that contains as much information as possible about the parameters to be identified. One way of obtaining such a non-homogeneous deformation is by making the geometry of the specimen less regular. Another possibility is to make the loading conditions more complex. In this paper both options are actually combined by using a biaxial tensile test on a cruciform specimen in order to identify the parameters of a Swift isotropic hardening law. The yield criterion is modeled by the isotropic Von Mises criterion. The optimization technique used is a constrained gradient based Newton-type routine, which means that in every iteration step, a sensitivity calculation has to be performed in order to indicate the direction in which the parameters are to be optimized. The functional to be minimized is a least-squares expression of the discrepancy between the measured and the simulated strain fields at a certain load. The numerical routines as well as the identification results, based on simulated strain fields, are discussed. [less ▲]

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See detailNumerical simulation in cold rolling using adiabatic strip model : application to large roll deformation
STEPHANY, A.; Ponthot, Jean-Philippe ULg; LEGRAND, N.

in AUSTRIB 06 (2006)

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See detailDermatophyties
Mignon, Bernard ULg

in Guaguère E., Prélaud P. (Ed.) Guide pratique de dermatologie canine (2006)

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See detailA note on syndeticity, recognizable sets and Cobham's theorem
Rigo, Michel ULg; Waxweiler, Laurent ULg

in Bulletin of the European Association for Theoretical Computer Science (2006), 88

In this note, we give an alternative proof of the following result. Let p,q>=2 be two multiplicatively independent integers. If an infinite set of integers is both p- and q-recognizable, then it is ... [more ▼]

In this note, we give an alternative proof of the following result. Let p,q>=2 be two multiplicatively independent integers. If an infinite set of integers is both p- and q-recognizable, then it is syndetic. Notice that this result is needed in the classical proof of the celebrated Cobham’s theorem. Therefore the aim of this paper is to complete [13] and [1] to obtain an accessible proof of Cobham’s theorem. [less ▲]

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See detailEvaluation des troubles fonctionnels du système respiratoire du cheval
Salinas, E.; Van Erck, Emmanuelle ULg; Lekeux, Pierre ULg et al

in Pratique Vétérinaire Equine (2006), 38(150), 29-39

Les troubles respiratoires sont fréquents chez le cheval. Il existe des tests fonctionnels complémentaires, réalisables soit sur le terrain soit en centres spécialisés.

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See detailDetermination of Vs-models for the Basel region: Comparison between Array measurements, SASW and S-wave reflection
Havenith, Hans-Balder ULg; Polom, Ulrich; Fäh, Donat et al

in Geophysical Research Abstracts (2006)

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See detailAléas climatiques versus actions anthropiques dans le développement des processus de « désertification » sur les marges sud et nord du Sahara
Taibi, Aude Nuscia; El Hannani, Mustapha; Gassani, Jean et al

in Interactions Nature-Société, analyses et modèles (2006)

Les marges sud et nord du Sahara sont soumises à des processus de dégradation anciens attestés par de nombreux travaux de terrain. Ils coïncident avec l'occurrence d'une sécheresse sévère sur les 3 sites ... [more ▼]

Les marges sud et nord du Sahara sont soumises à des processus de dégradation anciens attestés par de nombreux travaux de terrain. Ils coïncident avec l'occurrence d'une sécheresse sévère sur les 3 sites d'étude, débutée dans les années 1970 en Algérie (piémont sud de l'Atlas Saharien), au Maroc (bassin de l'oued Dadès) et en Mauritanie (lac d'Aleg, Brakna). Les suivis diachroniques par télédétection satellitaire (Landsat et SPOT) et aérienne (1954 à 2002) et des observations récentes, montrent la pérennité voire l'extension de certaines zones de dégradation localisées à proximité des agglomérations et points d'eau, malgré le retour des précipitations. Le rythme et les modalités de développement des dynamiques en œuvre, qui prennent la forme d'une dégradation qualitative et quantitative des couverts végétaux steppiques et de savane ainsi qu'une revivification des dunes d'Aleg, attestent du rôle prépondérant de certains activités humaines dans les processus de dégradation de ces milieux, en corrélation avec la crise climatique dont on peut se demander si elle n'est pas devenue un facteur secondaire. Sans ignorer les enjeux socio-économiques de développement, notre démarche vise à comprendre les logiques d'action des dynamiques complexes parfois abusivement désignées sous le terme simplificateur de «désertification». [less ▲]

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See detailFrom lectin-histochemistry to pregnancy diagnosis by lectin-ELISA: applications of lectins for the characterisation of bovine pregnancy-associated glycoprotein.
Klisch, K.; Melo de Sousa, Noelita ULg; Beckers, Jean-François ULg et al

in Proceedings of the XXVIth Congress of the European Association of Veterinary Anatomists (2006)

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See detailALADDIN: an optimized ground-based precursor for DARWIN
Coudé du Foresto, Vincent; Absil, Olivier ULg; Barillot, Marc et al

in Aime, C.; Vakili, F. (Eds.) Direct Imaging of Exoplanets: Science & Techniques (2006)

The ALADDIN concept is an integrated Antarctic-based L-band experiment whose purpose is to demonstrate nulling interferometry and to prepare the DARWIN mission. Because of their privileged location, the ... [more ▼]

The ALADDIN concept is an integrated Antarctic-based L-band experiment whose purpose is to demonstrate nulling interferometry and to prepare the DARWIN mission. Because of their privileged location, the relatively modest collectors (1 m) and baseline (up to 40 m) are sufficient to achieve a sensitivity (in terms of detectable zodi levels) which is about twice better than that of a nulling instrument on a large interferometer (such as GENIE at the VLTI), and to reach the 20-zodi threshold value identified to carry out the DARWIN precursor science. These numbers are based on a preliminary design study by Alcatel Alenia Space and were obtained using the same simulation software as the one employed for GENIE. The integrated design enables top-level optimization and full access to the light collectors for the duration of the experiment, while reducing the complexity of the nulling breadboard. [less ▲]

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See detailEléments de paléontologie
Javaux, Emmanuelle ULg

Learning material (2006)

powerpoint sur MyULg

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See detailBibliographie sélective
Provenzano, François ULg

in Denis, Benoît; De Marneffe, Daphné (Eds.) Les réseaux littéraires (2006)

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See detailRole of Sox 10 in the development of the inner ear
Bodson, M; Breuskin, I; Thelen, Nicolas ULg et al

Poster (2006)

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See detailImpact of the native-state stability of human lysozyme variants on protein secretion by Pichia pastoris
Kumita, Janet; Johnson, Russel; Alcocer, Marcos et al

in FEBS Journal (2006), 273

We report the secreted expression by Pichia pastoris of two human lysozyme variants F57I and W64R, associated with systemic amyloid disease, and describe their characterization by biophysical methods ... [more ▼]

We report the secreted expression by Pichia pastoris of two human lysozyme variants F57I and W64R, associated with systemic amyloid disease, and describe their characterization by biophysical methods. Both variants have a substantially decreased thermostability compared with wild-type human lysozyme, a finding that suggests an explanation for their increased propensity to form fibrillar aggregates and generate disease. The secreted yields of the F57I and W64R variants from P. pastoris are 200- and 30-fold lower, respectively, than that of wild-type human lysozyme. More comprehensive analysis of the secretion levels of 10 lysozyme variants shows that the low yields of these secreted proteins, under controlled conditions, can be directly correlated with a reduction in the thermostability of their native states. Analysis of mRNA levels in this selection of variants suggests that the lower levels of secretion are due to post-transcriptional processes, and that the reduction in secreted protein is a result of degradation of partially folded or misfolded protein via the yeast quality control system. Importantly, our results show that the human disease-associated mutations do not have levels of expression that are out of line with destabilizing mutations at other sites. These findings indicate that a complex interplay between reduced native-state stability, lower secretion levels, and protein aggregation propensity influences the types of mutation that give rise to familial forms of amyloid disease. [less ▲]

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