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See detailLong-term neurodevelopmental outcome and exercise capacity after corrective surgery for tetralogy of Fallot or ventricular septal defect in infancy.
Hovels-Gurich, Hedwig H; Konrad, Kerstin; Skorzenski, Daniela et al

in Annals of Thoracic Surgery (2006), 81(3), 958-66

BACKGROUND: The purpose of this prospective study was to assess whether neurodevelopmental status and exercise capacity of children 5 to 10 years after corrective surgery for tetralogy of Fallot or ... [more ▼]

BACKGROUND: The purpose of this prospective study was to assess whether neurodevelopmental status and exercise capacity of children 5 to 10 years after corrective surgery for tetralogy of Fallot or ventricular septal defect in infancy was different compared with normal children and influenced by the preoperative condition of hypoxemia or cardiac insufficiency. METHODS: Forty unselected children, 20 with tetralogy of Fallot and hypoxemia and 20 with ventricular septal defect and cardiac insufficiency, operated on with combined deep hypothermic circulatory arrest and low flow cardiopulmonary bypass at a mean age of 0.7 +/- 0.3 years (mean +/- SD), underwent, at mean age 7.4 +/- 1.6 years, standardized evaluation of neurologic status, gross motor function, intelligence, academic achievement, language, and exercise capacity. Results were compared between the groups and related to preoperative, perioperative, and postoperative status and management. RESULTS: Rate of mild neurologic dysfunction was increased compared with normal children, but not different between the groups. Exercise capacity and socioeconomic status were not different compared with normal children and between the groups. Compared with the normal population, motor function, formal intelligence, academic achievement, and expressive and receptive language were significantly reduced (p < 0.01 to p < 0.001) in the whole group and in the subgroups, except for normal intelligence in ventricular septal defect patients. Motor dysfunction was significantly higher in the Fallot group compared with the ventricular septal defect group (p < 0.01) and correlated with neurologic dysfunction, lower intelligence, and reduced expressive language (p < 0.05 each). Reduced New York Heart Association functional class was correlated with lower exercise capacity and longer duration of cardiopulmonary bypass (p < 0.05 each). Reduced socioeconomic status significantly influenced dysfunction in formal intelligence (p < 0.01) and academic achievement (p < 0.05). Preoperative risk factors such as prenatal hypoxia, perinatal asphyxia, and preterm birth, factors of perioperative management such as cardiac arrest, lowest nasopharyngeal temperature, and age at surgery, and postoperative risk factors as postoperative cardiocirculatory insufficiency and duration of mechanical ventilation were not different between the groups and had no influence on outcome. Degree of hypoxemia in Fallot patients and degree of cardiac insufficiency in ventricular septal defect patients did not influence the outcome within the subgroups. CONCLUSIONS: Children with preoperative hypoxemia in infancy are at higher risk for motor dysfunction than children with cardiac insufficiency. Corrective surgery in infancy for tetralogy of Fallot or ventricular septal defect with combined circulatory arrest and low flow bypass is associated with reduced neurodevelopmental outcome, but not with reduced exercise capacity in childhood. In our experience, the general risk of long-term neurodevelopmental impairment is related to unfavorable effects of the global perioperative management. Socioeconomic status influences cognitive capabilities. [less ▲]

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See detailManagement of soils polluted by heavy metals in cultivated areas : which kind of bioremediation ?
Schvartz, Christian; Zu, Yanqun; Douay, Francis et al

Conference (2006)

Within the periurban areas of big cities, soils are often contaminated by heavy metals spread by human activity: atmospheric fallouts due to industry and traffic, recycling of urban wastes (directly or ... [more ▼]

Within the periurban areas of big cities, soils are often contaminated by heavy metals spread by human activity: atmospheric fallouts due to industry and traffic, recycling of urban wastes (directly or after water treatment), fertilizers and pesticides used in agriculture… This is, among others, verified in the surroundings of Kunming (Yunnan, PR China) and Lille (Nord-Pas de Calais, France), areas with high density of population and traditional metallurgical industries. These areas have also intensive agricultural activities characterized by important vegetable productions, and are generally known as the "green belts" of the cities. These cultures, with short vegetative period, need high biodisponibility of nutrients, biodisponibility which may also occur for other unwanted elements existing in the soil, such as heavy metals. For evident human health reasons the quality of the crops must be ensured and their heavy metal content kept as low as possible, at least under the values of relevant legal thresholds. Thus, vegetables are particularly sensitive to the presence of heavy metals in the soils where they are growing. It is therefore necessary to manage these soils in order to preserve public health or, more basically, the income of the farmers, as contaminated vegetables would not be marketable. Thus, for these large areas contaminated by diffuse pollution, bioremediation looks to be appropriate. But the kind of the bioremediation which will be applied has to be adapted to the severity of the soil pollution and to the intended land use. In this project, we have assessed the contents of Pb, Cd, Zn and Cu of soils and vegetables within the Chenggong county (near Kunming), and compared the results to the already known situation of the surroundings of two lead and zinc smelters located close to Lille. Then goals and ways of bioremediation have been discussed and the first steps of implementation experimented. [less ▲]

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See detailLes Fonts de Liège. De l’art antique à l’art mosan : sources iconographiques et stylistiques
George, Philippe ULg

in Halleux, Robert; Xhayet, Geneviève (Eds.) Etudes sur les fonts baptismaux de Saint-Barthélemy à Liège, (2006)

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See detailSox 10 is not necessary for auditory neurons survival
Breuskin, I; Bodson; Thelen, Nicolas ULg et al

Poster (2006)

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See detailIdentités et politique : quinze ans dans un miroir
Italiano, Patrick ULg

in Fédéralisme - Régionalisme (2006), 6

Synthèse de l'évolution, en quinze ans, des sentiments d'appartenance wallon, belge et européen de leurs dynamiques respectives, et mis en perspective des fluctuation avec les événements politiques des ... [more ▼]

Synthèse de l'évolution, en quinze ans, des sentiments d'appartenance wallon, belge et européen de leurs dynamiques respectives, et mis en perspective des fluctuation avec les événements politiques des périodes considérées. [less ▲]

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See detailLa politique industrielle sous les tirs croisés de la mondialisation et du droit communautaire de la concurrence
Petit, Nicolas ULg

in Mondialisation politique industrielle et droit comm de la concurrence (2006)

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See detailSeismic microzonation of slopes susceptible to landsliding : Use of Ambient noise and Earthquake Ground Motion Measurements
Havenith, Hans-Balder ULg; Torgoev, Isakbek; Alvarez, Sonya et al

in Geophysical Research Abstracts (2006)

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See detailPhysical activity patterns of children after neonatal arterial switch operation.
Massin, Martial M; Hovels-Gurich, Hedwig H; Gérard, Paul ULg et al

in Annals of Thoracic Surgery (2006), 81(2), 665-70

BACKGROUND: Physical inactivity is a major atherosclerosis risk factor. The exercise tolerance is usually excellent after neonatal arterial switch operation, but those patients in whom coronary anomalies ... [more ▼]

BACKGROUND: Physical inactivity is a major atherosclerosis risk factor. The exercise tolerance is usually excellent after neonatal arterial switch operation, but those patients in whom coronary anomalies remain the main late complication, risk developing atherosclerotic coronary disease owing to perceived physical activity restrictions. METHODS: We investigated physical activity patterns of 52 unselected children 7 to 14 years after neonatal arterial switch operation for transposition of the great arteries by 24-hour continuous heart rate monitoring. The percentage of heart rate reserve was used to measure the amounts of activities. Comparisons were made with 35 children with repaired atrial or ventricular septal defect and with 127 age-matched healthy children. RESULTS: Children after arterial switch operation accumulated 167.3 +/- 70.6, 25.3 +/- 12.9, and 15.7 +/- 11.3 minutes a day (mean +/- SD) of light, moderate, and vigorous physical activities, respectively. At the same activity levels, children with repaired septal defect accumulated 165.2 +/- 82.2, 26.2 +/- 11.7, and 16.2 +/- 9.1 minutes a day, and their healthy peers 164.8 +/- 74.5, 31.8 +/- 13.9, and 21.9 +/- 11.3 minutes a day. Both cardiac groups were significantly less active than the control group when considering moderate (p = 0.026) and vigorous activities (p = 0.006). Only 19% and 27% of the children after arterial switch operation engaged, respectively, in more than 30 minutes a day of moderate activity and 20 minutes a day of vigorous activity. CONCLUSIONS: Children after arterial switch operation, just like other cardiac children, do not meet the guidelines for physical activity. We should encourage regular physical activity to offset adult sedentary behavior and to prevent atherosclerotic cardiovascular disease in those patients whose long-term function of the coronary arteries remains a matter of concern. [less ▲]

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See detailRapport de mission (du 30.09 au 11.10.2006) : AMELIORATION DE L’HABITAT ET DES INFRASTRUCTURES SOCIO-ECONOMIQUES POUR UN DEVELOPPEMENT INTEGRE DE LA COLLECTIVITE RURALE DE WAMAZA-MANIEMA EN REPUBLIQUE DEMOCRATIQUE DU CONGO
Hanocq, Philippe ULg

Report (2006)

Avec l’appui du service d’urbanisme de l’ULg, une série de projets sociaux ont été identifiés en 1995 à Wamaza, dans la région du Maniema et du Sud Kivu, en République Démocratique du Congo. Cela a permis ... [more ▼]

Avec l’appui du service d’urbanisme de l’ULg, une série de projets sociaux ont été identifiés en 1995 à Wamaza, dans la région du Maniema et du Sud Kivu, en République Démocratique du Congo. Cela a permis d’initier un programme de recherche - action couvrant un large éventail d’interventions entrant dans le champ de l’aménagement du territoire et de l’urbanisme. Le programme de recherche s’appuyait sur une idée maîtresse : « l’amélioration de l’habitat rural peut freiner l’exode rural et contribuer ainsi au développement endogène des collectivités paysannes ». [less ▲]

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See detailOK3: Méthode d’arbres à sortie noyau pour la prédiction de sorties structurées et l’apprentissage de noyau
Geurts, Pierre ULg; Wehenkel, Louis ULg; d'Alché-Buc, Florence

in Proc. of CAP (Conférence francophone d'apprentissage) (2006)

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See detailControlled radical polymerization of vinyl monomers catalyzed by ruthenium N-heterocyclic carbene complexes
Delfosse, Sébastien; Richel, Aurore ULg; Delaude, Lionel ULg et al

in Matyjaszewski, K. (Ed.) Progress in Controlled/Living Radical Polymerization / ACS Symposium Series 944 (2006)

The relative catalytic activities of a series of ruthenium-based complexes of the general formula [RuCl2(p-cymene)(NHC)], [RuCl2(=CHPh)(PR3)(NHC)] and [RuCl2(=CHPh)(NHC)2] (NHC is a N-heterocyclic carbene ... [more ▼]

The relative catalytic activities of a series of ruthenium-based complexes of the general formula [RuCl2(p-cymene)(NHC)], [RuCl2(=CHPh)(PR3)(NHC)] and [RuCl2(=CHPh)(NHC)2] (NHC is a N-heterocyclic carbene ligand) were determined by investigating the atom transfer radical polymerization (ATRP) of methyl mathacrylate and styrene. The catalytic activity of a variety of related [RuCl(O^N)(=CHR)(NHC)] complexes and their cationic couterparts, [Ru(O^N)(=CHR)(NHC)]+BF4- (R = Ph or OEt, O^N is a Schiff base ligand), is also reported. The results clearly demonstrate that, with both methyl methacrylate and styrene, subtle modifications of the substituents of the NHC ligand lead to dramatic changes in the ability of the resulting ruthenium complexes to favor the occurence of a well-behaved ATRP. [less ▲]

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See detailStudy of the modes of action of two biocontrol agents Z1 and ZH2
Drider, R.; Friel, D.; El Guilli, M. et al

Poster (2006)

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See detailThe Yin and Yang of cell cycle progression and differentiation in the oligodendroglial lineage
Nguyen, Laurent ULg; Borgs, Laurence ULg; Vandenbosch, Renaud ULg et al

in Mental Retardation & Developmental Disabilities Research Reviews (2006), 12(2), 85-96

In white matter disorders such as leukodystrophies (LD), periventricular leucomalacia (PVL), or multiple sclerosis (MS), the hypomyelination or the remyelination failure by oligodendrocyte progenitor ... [more ▼]

In white matter disorders such as leukodystrophies (LD), periventricular leucomalacia (PVL), or multiple sclerosis (MS), the hypomyelination or the remyelination failure by oligodendrocyte progenitor cells involves errors in the sequence of events that normally occur during development when progenitors proliferate, migrate through the white matter, contact the axon, and differentiate into myelin-forming oligodendrocytes. Multiple mechanisms underlie the eventual progressive deterioration that typifies the natural history of developmental demyelination in LID and PVL and of adult-onset demyelination in MS. Over the past few years, pathophysiological studies have mostly focused on seeking abnormalities that impede oligodendroglial maturation at the level of migration, myelination, and survival. In contrast, there has been a strikingly lower interest for early proliferative and differentiation events that are likely to be equally critical for white matter development and myelin repair. This review highlights the Yin and Yang principles of interactions between intrinsic factors that coordinately regulate progenitor cell division and the onset of differentiation, i.e. the initial steps of oligodendrocyte lineage progression that are obviously crucial in health and diseases. (C) 2006 Wiley-Liss, Inc. [less ▲]

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See detailProteomic analysis of ovine muscle hypertrophy.
Hamelin, M.; Sayd, T.; Chambon, C. et al

in Journal of Animal Science (2006), 84(12), 3266-76

Two-dimensional electrophoresis was used to investigate the effects of a QTL for muscle hypertrophy on sarcoplasmic protein expression in ovine muscles. In the Belgian Texel breed, the QTL for muscle ... [more ▼]

Two-dimensional electrophoresis was used to investigate the effects of a QTL for muscle hypertrophy on sarcoplasmic protein expression in ovine muscles. In the Belgian Texel breed, the QTL for muscle hypertrophy is localized in the myostatin-encoding gene. Based on microsatellite markers flanking the myostatin gene, we compared the hypertrophied genotype with the normal genotype. The average age of the sheep was 3 mo. Among the 4 muscles studied, in the hypertrophied genotype only the vastus medialis was normal, whereas the semimembranosus, tensor fasciae latae, and LM were hypertrophied. In the hypertrophied genotype, these muscles showed upregulation of enzymes involved in glycolytic metabolism together with oxidative metabolism in LM. Certain chaperone proteins, including glutathione S-transferase-Pi, heat shock protein-27, and heat shock cognate-70, were also more highly expressed, probably due to increased use of energetic pathways. Expression of the iron transport protein transferrin was increased. Alpha-1-antitrypsin was the only protein showing a similar pattern of expression (i.e., less expressed) in all 4 muscles of the hypertrophied genotype. It is suggested that transferrin and alpha-1-antitrypsin may interact to reinforce myogenic proliferative signaling. [less ▲]

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