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See detailPeroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis
Relic, Biserka ULg; Benoit, Valerie; Franchimont, Nathalie et al

in Journal of Biological Chemistry (2006), 281(32), 597-604

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a central role in whole body metabolism by regulating adipocyte differentiation and energy storage. Recently, however, PPAR-gamma has ... [more ▼]

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a central role in whole body metabolism by regulating adipocyte differentiation and energy storage. Recently, however, PPAR-gamma has also been demonstrated to affect proliferation, differentiation, and apoptosis of different cell types. As we have previously shown that BAY 11-7085-induced synovial fibroblast apoptosis is prevented by PPAR-gamma agonist 15d-PGJ2; the expression of PPAR-gamma in these cells was studied. Both PPAR-gamma1 and PPAR-gamma2 isoforms were cloned from synovial fibroblast RNA, but only PPAR-gamma1 was detected by Western blot, showing constitutive nuclear expression. Within minutes of BAY 11-7085 treatment, a PPAR-gamma1-specific band was shifted into a form of higher mobility, suggesting dephosphorylation, as confirmed by phosphatase treatment of cell extracts. Of interest, BAY 11-7085-induced PPAR-gamma1 dephosphorylation was followed by PARP and caspase-8 cleavage as well as by PPAR-gamma1 protein degradation. PPAR-gamma1 dephosphorylation was followed by the loss of PPAR-DNA binding activity ubiquitously present in synovial fibroblast nuclear extracts. Unlike the phosphorylated form, dephosphorylated PPAR-gamma1 was found in insoluble membrane cell fraction and was not ubiquitinated before degradation. PPAR-gamma1 dephosphorylation coincided with ERK1/2 phosphorylation that accompanies BAY 11-7085-induced synovial fibroblasts apoptosis. 15d-PGJ2, PGD2, and partially UO126, down-regulated ERK1/2 phosphorylation, protected cells from BAY 11-7085-induced apoptosis, and reversed both PPAR-gamma dephosphorylation and degradation. Furthermore, PPAR-gamma antagonist BADGE induced PPAR-gamma1 degradation, ERK1/2 phosphorylation, and synovial fibroblasts apoptosis. The results presented suggest an anti-apoptotic role for PPAR-gamma1 in synovial fibroblasts. Since apoptotic marker PARP is cleaved after PPAR-gamma1 dephosphorylation but before PPAR-gamma1 degradation, dephosphorylation event might be enough to mediate BAY 11-7085-induced apoptosis in synovial fibroblasts. [less ▲]

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See detailMieux mesurer l'arthrose.
Henrotin, Yves ULg

Article for general public (2006)

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See detailLa traducción entre siglos: un proyecto nacional
Willson, Patricia ULg

in Rubione, Alfredo (Ed.) Historia crítica de la literatura argentina. Volumen 5: La crisis de las formas (2006)

The formal and thematic novelties or peculiarities contributed by foreign literature, their relationship to national literature, the characterization of the importing agents, and the question of language ... [more ▼]

The formal and thematic novelties or peculiarities contributed by foreign literature, their relationship to national literature, the characterization of the importing agents, and the question of language in concrete strategies of translation constitute decisive elements to establish the history of translation in a given culture. In the context of a specific period in the history of Argentine literature, this chapter delves into the origins and shaping of one of the major publishing undertakings of the turn of the century, «La Biblioteca de La Nación», where translation was central and which, according to our hypothesis, was stimulated by the political ideas of the Generation of the Eighties dating back to the 19th century. [less ▲]

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See detailPolitiques de l'autobiographie chez Sartre
Denis, Benoît ULg

in Temps Modernes (Les) (2006), (641), 149-167

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See detailRole of Sox 10 in the development of the inner ear
Bodson, M; Breuskin, I; Thelen, Nicolas ULg et al

Poster (2006)

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See detailCoupled modelling of an excavation in a brittle formation
Collin, Frédéric ULg; Li, Xian Ling; Chambon, René et al

Conference (2006)

This paper is concerned with the coupling effects existing between the mechanical problem and the water diffusion process during an excavation, in relation with the nuclear waste disposal concepts. The ... [more ▼]

This paper is concerned with the coupling effects existing between the mechanical problem and the water diffusion process during an excavation, in relation with the nuclear waste disposal concepts. The hydromechanical coupling effects are first evidenced. Then, the permeability variation with damage is studied. Finally, different kind of flow boundary condition are considered. Their influence on the cavity convergence is highlighted and their effect on strain localisation process as well. [less ▲]

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See detailEffets symptomatiques de la glucosamine dans l’arthrose
Reginster, Jean-Yves ULg; Bruyère, Olivier ULg

in Pharma-Sphère (2006), 110

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See detailTreatment of anaemia with erythropoietin
Beguin, Yves ULg; Dujardin, C.; Piron, Maude ULg et al

in Brugnara, C.; Beaumont, C. (Eds.) ESH Scientific Updates. Disorders of Iron Homeostasis, Erythrocytes and erythropoiesis (2006)

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See detailBaryon resonances in large N(c) QCD
Matagne, Nicolas; Stancu, Floarea ULg

in Bled Workshops in Physics (2006), 7(1), 61-66

The baryon spectra are discussed in the context of the $1/N_c$ expansion approach, with emphasis on mixed symmetric states. The contributions of the spin dependent terms as a function of the excitation ... [more ▼]

The baryon spectra are discussed in the context of the $1/N_c$ expansion approach, with emphasis on mixed symmetric states. The contributions of the spin dependent terms as a function of the excitation energy are shown explicitly. At large energies these contributions are expected to vanish. [less ▲]

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See detailAnalytical validation of potentiometric method for cetirizinium ion
Rachidi, Mohamed ULg; Digua, K.; Hubert, Philippe ULg et al

in Analytical Letters (2006), 39(8), 1699-1708

Accuracy and reliability of the analytical results are crucial for ensuring quality, safety, and efficacy of pharmaceutical products. However, to ensure these criteria, analytical validation is required ... [more ▼]

Accuracy and reliability of the analytical results are crucial for ensuring quality, safety, and efficacy of pharmaceutical products. However, to ensure these criteria, analytical validation is required. In this matter, many official documents describing the criteria of validation are available. However, these concern mainly chromatography analysis and bio-analytical methods of pharmaceutical products, but they do not propose any experimental protocol for direct potentiometric methods using ion-selective electrodes applied in pharmaceutical analysis. In this work, we are proposing a validation strategy based on the normative and regulatory guidelines applied to a potentiometric method with a polymeric membrane selective to cetirizine dihydrochloride. The statistical analysis obtained from raw data is described for all steps of this protocol. Also this validated method was successfully applied to the determination of cetirizine in pharmaceutical preparations using direct potentiometry with a mean relative standard deviation of 0.57% and a mean recovery of 99.63%. [less ▲]

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See detailAdherence to anti-osteoporotic treatment: does it really matter?
Reginster, Jean-Yves ULg; Rabenda, Véronique ULg

in Future Rheumatology (2006), 1

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See detailSynchronization of validation and estimation strategies of doubt associated as part of the accreditation in trial laboratories
Hubert, Philippe ULg; Rozet, Eric ULg; Boulanger, Bruno ULg et al

in Acta Clinica Belgica (2006), 61(Suppl. 1), 54-56

In order to achieve the harmonization of validation strategies, the interpretation of several validation criteria is proposed. Furthermore, a simple and visual decision tool to assess the validity of an ... [more ▼]

In order to achieve the harmonization of validation strategies, the interpretation of several validation criteria is proposed. Furthermore, a simple and visual decision tool to assess the validity of an analytical procedure is described: the accuracy profile based on the estimation of the total error of the measurements. This profile build with beta-expectation tolerance intervals can also compute with efficiency the uncertainty related to the results of a laboratory, which is an essential parameter for the accreditation of laboratories under ISO 17025. [less ▲]

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See detailRéseaux et bases de données
Dozo, Björn-Olav ULg; Fréché, Bibiane

in Denis, Benoît; de Marneffe, Daphné (Eds.) Les Réseaux littéraires (2006)

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See detailLangues et immigration dans l’enseignement en Communauté française de Belgique
Lucchini, Silvia ULg

in Conseil supérieur de la langue française et Service de la langue française de la Communauté française de Belgique (Ed.) Langue française et diversité linguistique (2006)

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See detailPrediction of deformation textures in zirconium based on a simplified modelling of grain interaction
Lelotte, Thomas; Delannay, L.; Habraken, Anne ULg

in Khan, A. S. (Ed.) Proceedings of the Plasticity Conference 2006 (2006)

The goal of this study is to apply a “multisite” crystal plasticity model to the prediction of texture evolution in zirconium deformed at high temperature. The model under consideration is an extension of ... [more ▼]

The goal of this study is to apply a “multisite” crystal plasticity model to the prediction of texture evolution in zirconium deformed at high temperature. The model under consideration is an extension of the elastic-viscoplastic “multisite model” proposed by Delannay et al. [2005] which has been adapted to account for a new type of grain interaction (Van Houtte et al. [2005]). Predictions of the model are compared to experimental data. Two forming processes are considered: sheet rolling (Lebensohn et al. [1994]) and the torsion of a cylindrical bar (Sanchez et al. [2001]). [less ▲]

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See detailInclusion of a stress-dependent Preisach model in 2D FE calculations
Benabou, A.; Vandenbossche, L.; Gyselinck, Johan et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2006), 25(1), 81-90

Purpose - Mechanical stress can heavily affect the magnetic behaviour law in ferromagnetic materials. This paper, aims to take into account the effect of mechanical stress into a hystreresis model. This ... [more ▼]

Purpose - Mechanical stress can heavily affect the magnetic behaviour law in ferromagnetic materials. This paper, aims to take into account the effect of mechanical stress into a hystreresis model. This model is implemented in a finite element analysis code and tested in the case of a simple system. Design/methodology/approach - A simple extension of the classical Preisach model is proposed, in which a function linked to the Preisach density is parameterized using the mechanical stress as a supplementary parameter. The methodology is based on experimental measurements for identifying the required function. As a first approach, a linear interpolation is used between the measurements in order to have a continuous evolution of the magneto-mechanical behaviour. This model has been tested in the case of a steel sheet in which width is not constant in order to obtain a non-uniform distribution of stress and magnetic flux density. Findings - The model can predict the magneto-mechanical behaviour with a good accuracy in the case of tensile stress. Implementation of the model in finite element analysis has shown that the model can predict the behaviour of steel sheet subject to a non-uniform stress distribution. Originality/value - This paper shows that a classical hysteresis model can be extended to take into account the magneto-mechanical behaviour. This is useful for the design of electrical machines which are subject to non-negligible mechanical stress. [less ▲]

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