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See detailSynthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2-H-1-benzopyran-4-yl)ureas structurally related to cromakalim
Khelili, S.; Lebrun, P.; De Tullio, Pascal ULg et al

in Bioorganic & Medicinal Chemistry (2006), 14

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See detailL'Amérique latine: champs favorables pour le renforcement de l'identité extérieure de l'Union européenne?
Santander, Sébastian ULg

in Aparicio, Miriam (Ed.) L'identité en Europe et sa trace dans le monde (2006)

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See detailExtending postgrafting cyclosporine decreases the risk of severe graft-versus-host disease after nonmyeloablative hematopoietic cell transplantation
Burroughs, Lauri; Mielcarek, Marco; Leisenring, Wendy et al

in Transplantation (2006), 81(6), 818-25

BACKGROUND: It is unknown whether the duration of systemic immunosuppressive treatment after allogeneic nonmyeloablative hematopoietic cell transplantation (HCT) might influence the incidence, severity ... [more ▼]

BACKGROUND: It is unknown whether the duration of systemic immunosuppressive treatment after allogeneic nonmyeloablative hematopoietic cell transplantation (HCT) might influence the incidence, severity, timing, and/or corticosteroid-responsiveness of graft-versus-host disease (GVHD). METHODS: We retrospectively analyzed outcomes among 185 patients with hematologic malignancies who were given grafts from HLA-matched related donors following conditioning with 2 Gy total body irradiation alone or in combination with fludarabine between December 1998 and March 2003. Postgrafting immunosuppression consisted of mycophenolate mofetil (days 0-27) in combination with 3 different cyclosporine (CSP) regimens: taper from (A) days 35 to 56 (n=107), (B) days 56 to 77 (n=35), and (C) days 56 to 180 (n=43). RESULTS: The overall incidences of grades II-IV and III-IV acute GVHD, and extensive chronic GVHD were 52%, 13%, and 56%, respectively. The duration of CSP prophylaxis did not significantly influence the overall rate of acute GVHD (grade II-IV), extensive chronic GVHD, or non-relapse mortality. However, prolonged administration of CSP (group C) was associated with a significantly decreased hazard of grades III-IV acute GVHD (HR 0.2, 95% CI [0.04, 0.9]) and with an increased likelihood of discontinuing all systemic immunosuppression (HR 2.4, 95% CI [1.1, 5.2]) when compared to the shortest course of CSP (group A). CONCLUSION: Longer CSP duration decreased the risk of severe GVHD and increased the likelihood of discontinuing all systemic immunosuppression after nonmyeloablative HCT with HLA-matched related grafts. [less ▲]

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See detailPlis et enveloppements chez Leibniz
Bouquiaux, Laurence ULg

in Différence et identité. Les enjeux phénoménologiques du pli (2006)

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See detailp27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex.
Nguyen, Laurent ULg; Besson, Arnaud; Heng, Julian Ik-Tsen et al

in Genes & Development (2006), 20(11), 1511-24

The generation of neurons by progenitor cells involves the tight coordination of multiple cellular activities, including cell cycle exit, initiation of neuronal differentiation, and cell migration. The ... [more ▼]

The generation of neurons by progenitor cells involves the tight coordination of multiple cellular activities, including cell cycle exit, initiation of neuronal differentiation, and cell migration. The mechanisms that integrate these different events into a coherent developmental program are not well understood. Here we show that the cyclin-dependent kinase inhibitor p27(Kip1) plays an important role in neurogenesis in the mouse cerebral cortex by promoting the differentiation and radial migration of cortical projection neurons. Importantly, these two functions of p27(Kip1) involve distinct activities, which are independent of its role in cell cycle regulation. p27(Kip1) promotes neuronal differentiation by stabilizing Neurogenin2 protein, an activity carried by the N-terminal half of the protein. p27(Kip1) promotes neuronal migration by blocking RhoA signaling, an activity that resides in its C-terminal half. Thus, p27(Kip1) plays a key role in cortical development, acting as a modular protein that independently regulates and couples multiple cellular pathways contributing to neurogenesis. [less ▲]

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See detailNumerical modelling of coupled poromechanics processes
Charlier, Robert ULg; Laloui, Liesse; Collin, Frédéric ULg

in Revue Européenne de Génie Civil (2006), 10(6-7), 669-702

This paper is the basis for a course dedicated to geomechanics for energy production. A number of different coupling are discussed, with respectively the fluid flow (saturated and unsaturated) and the ... [more ▼]

This paper is the basis for a course dedicated to geomechanics for energy production. A number of different coupling are discussed, with respectively the fluid flow (saturated and unsaturated) and the thermal transfers in deformable porous media. Eventually some aspects on the numerical modelling with the finite element method are discussed. [less ▲]

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See detailComparison between homogeneous and heterogeneous field information for plastic material identification
Lecompte, D.; Sol, H.; Vantomme, J. et al

in Grédiac, Michel; Huntley, Jonathan (Eds.) Proceedings of Photomecanics Conference 2006 (2006)

The accuracy of a Finite Element Simulation for plastic deformation strongly depends on the chosen constitutive laws and the value of the material parameters within these laws. The identification of those ... [more ▼]

The accuracy of a Finite Element Simulation for plastic deformation strongly depends on the chosen constitutive laws and the value of the material parameters within these laws. The identification of those mechanical parameters can be done based on homogeneous stress and strain fields such as those obtained in uniaxial tensile tests and simple shear tests performed in different plane material directions. Another way to identify plastic material parameters is by inverse modeling of an experiment exhibiting a heterogeneous stress and strain field. Experimental forces and strains are in this case compared to the simulated ones and it is tried to reduce the difference in a least-squares sense by optimizing the model parameters. The optimization technique used is this case is gradient based, which means that at every iteration a sensitivity calculation has to be performed in order to indicate the direction in which the parameters are to be identified. The basic principle of the inverse modeling procedure as it is used for parameter identification is the generation of a complex and heterogeneous deformation field that contains as much information as possible about the parameters to be identified. One way of obtaining such a non-homogeneous deformation is by altering the geometry of the specimen for a uniaxial test. Another possibility is to make the loading conditions more complex. In this paper both options are actually combined by using a biaxial tensile test on a perforated cruciform specimen. In the present paper, the work hardening of the material is assumed to be isotropic and it is described by a Swift law. The yield locus is modeled by the anisotropic Hill48 criterion. A comparison is made between the identification of the Hill48 parameters based on the one hand on the Lankford coefficients [1] and on the inverse modeling of a biaxial tensile test on the other hand [less ▲]

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See detailRéseaux et institution faible
Denis, Benoît ULg; Aron, Paul

in Denis, Benoît; de Marneffe, Daphné (Eds.) Les Réseaux littéraires (2006)

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See detaillymphatic ring assay: a new in vitro model of lymphangiogenesis
Bruyère, F; Melen, L; Blacher, Silvia ULg et al

Poster (2006)

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See detailFotogrammi per una "consegna del testimone" : Da Guy Tosi a Ivanos Ciani e alla giovane critica
Curreri, Luciano ULg

in Cappellini, Milva Maria; Zollino, Antonio (Eds.) D'Annunzio e dintorni : Studi per Ivanos Ciani (2006)

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See detailLes angles corniculaires et l'infiniment petit
Bair, Jacques ULg; Henry, Valérie ULg

in Tangente Sup (2006), 31(mai-juin), 4-7

Nous mettons en évidence le fait que des angles entre un demi-cercle et une droite tangente mène au concept d'infiniment petit.

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See detailGeneralized shape optimization using X-FEM and Level Set methods
Duysinx, Pierre ULg; Van Miegroet, Laurent ULg; Jacobs, Thibaut et al

in Bendsoe, M.-P.; Olhoff, N.; Sigmund, O. (Eds.) IUTAM Sumposium on Topological Design Optimization of Structures, Machines, and Materials. Status and Perspectives (2006)

This paper presents an intermediate approach between parametric shape optimization and topology optimization. It is based on using the recent Level Set description of the geometry and the novel eXtended ... [more ▼]

This paper presents an intermediate approach between parametric shape optimization and topology optimization. It is based on using the recent Level Set description of the geometry and the novel eXtended Finite Element Method (XFEM). The method takes benefit of the fixed mesh work using X-FEM and of the curves smoothness of the Level Set description. Design variables are shape parameters of basic geometric features. The number of design variables of this formulation is small whereas various global and local constraints can be considered. The Level Set description allows to modify the connectivity of the structure as geometric features can merge or separate from each other. However no new entity can be introduced. A central problem that is investigated here is the sensitivity analysis and the way it can be carried out efficiently. Numerical applications revisit the classical elliptical hole benchmark from shape optimization. [less ▲]

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See detailCompte rendu des actes du colloque : Identités franciscaines à l’âge des réformes
Delfosse, Annick ULg

in Moyen Age (Le) (2006), 112(3-4), 692-693

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See detailDie Dämonie von Verlassenheit und Fremde in den Erzählungen Stefan Zweigs. Abstract
Küpper, Achim ULg

in Stefan Zweig und das Dämonische: Abstracts (2006)

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See detailComparative study of durability test methods for pellets and briquettes
Temmerman, Michaël ULg; Rabier, Fabienne; Daugbjerg Jensen, Peter et al

in Biomass & Bioenergy (2006)

Different methods for the determination of the mechanical durability (DU) of pellets and briquettes were compared by international round robin tests including different laboratories. The DUs of five ... [more ▼]

Different methods for the determination of the mechanical durability (DU) of pellets and briquettes were compared by international round robin tests including different laboratories. The DUs of five briquette and 26 pellet types were determined. For briquettes, different rotation numbers of a prototype tumbler and a calculated DU index are compared. For pellets testing, the study compares two standard methods, a tumbling device according to ASAE S 269.4, the Lignotester according to O¨ NORM M 7135 and a second tumbling method with a prototype tumbler. For the tested methods, the repeatability, the reproducibility and the required minimum number of replications to achieve given accuracy levels were calculated. Additionally, this study evaluates the relation between DU and particle density. The results show for both pellets and briquettes, that the measured DU values and their variability are influenced by the applied method. Moreover, the variability of the results depend on the biofuel itself. For briquettes of DU above 90%, five replications lead to an accuracy of 2%, while 39 replications are needed to achieve an accuracy of 10%, when briquettes of DU below 90% are tested. For pellets, the tumbling device described by the ASAE standard allows to reach acceptable accuracy levels (1%) with a limited number of replications. Finally, for the tested pellets and briquettes no relation between DU and particle density was found. [less ▲]

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See detailPercutaneous coronary intervention for bifurcation disease.A consensus view from the first meeting of the European Bifurcation Club.
Thomas, Martyn; Hildick-Smith, David; Louvard, Yves et al

in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2006), 2(2), 149-53

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See detailLe retable de l'église Saint-Denis. Les panneaux peints de la prédelle: analyse technologique
Oger, Cécile ULg

in Denhaene, Godelieve (Ed.) Lambert Lombard, Peintre de la Renaissance. Liège 1505/06-1566 :Essais interdiscipinaires et catalogue de l'exposition (2006)

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