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See detailBiodegradable microparticles loaded with thrombin receptor agonist peptide for gastric ulcer treatment in rats
Markvicheva, E.; Stashevskaya, K.; Strukova, S. et al

in Journal of Drug Delivery Science and Technology (2006), 16(4, JUL-AUG), 321-325

The aim of the current paper was to elaborate an immobilization method of thrombin receptor agonist peptide (TRAP-6) in biodegradable biocompatible poly(d,l)-lactide-co-glycolide (PLGA) inicroparticles ... [more ▼]

The aim of the current paper was to elaborate an immobilization method of thrombin receptor agonist peptide (TRAP-6) in biodegradable biocompatible poly(d,l)-lactide-co-glycolide (PLGA) inicroparticles and to demonstrate the effect of the entrapped peptide for tissue repair, namely,for a gastric ulcer treatment in rats. TRAP-6 was entrapped in polymer using w/o/w double emulsion-evaporation technique. The morphology of empty and TRAP-6 loaded microparticles was evaluated by light and scanning electron microscopy (SEM). In vitro release kinetics profile of TRAP-6 from microparticles was studied by HPLC. To investigate gastric mucosal protection effect in vivo, TRAP-6-loaded microparticles were administered in a rat stomach after a previous mucosal injury (a gastric ulcer). Microparticles with entrapped TRAP-6 were found to reduce both an inflammation and proliferation phases of wound healing, and thus accelerated tissue repair in rats. [less ▲]

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See detailMaterials for advanced power engineering 2006 : Proceedings of the 8th Liège conference
Lecomte-Beckers, Jacqueline ULg; Carton, Marc ULg; Schubert, F. et al

Book published by Schriften des Forschungszentrum Julich, Reihe energietechnik/Energy Technology Forschungszentrum Julich (2006)

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See detailReconstruction of glottic defects after endoscopic cordectomy: voice outcome.
Remacle, Marc; Lawson, Georges; Morsomme, Dominique ULg et al

in Otolaryngologic Clinics of North America (2006), 39(1), 191-204

Medialization thyroplasty for correction of glottic gap, keel placement after laser-assisted section, and topical application of mitomycin-C for anterior glottic synechiae are effective procedures for ... [more ▼]

Medialization thyroplasty for correction of glottic gap, keel placement after laser-assisted section, and topical application of mitomycin-C for anterior glottic synechiae are effective procedures for voice restoration after endoscopic cordectomy. Only a minority of patients (16.4% of the authors’ patients after total or extended cordectomies) request this voice restoration. In this regard, self-evaluation questionnaires (eg, VHI) probably are the most useful tools, along with stroboscopy, for voice assessment. Careful elevation of the fibrous tissue from the inner surface of the thyroid cartilage is a tedious and lengthy step, but is critical in successful medialization after cordectomy; therefore, general anesthesia is preferable. Transoral keel placement is still advisable in cases of thick synechiae. The Lichtenberger technique has been a major advancement to the transoral approach, and is the preferred technique of the authors. [less ▲]

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See detailChanges in albumen pH due to higher CO2 concentrations during the first ten days of incubation
Bruggeman, V.; De Smit, L.; Tona, K. et al

Conference (2006)

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See detailHobbes ou le déclin du Royaume des ténèbres. Politique et théologie dans le Léviathan.
Herla, Anne ULg

Book published by Kimé (2006)

Qu'elles soient considérées comme une tentative de légitimation hypocrite ou comme une attestation de foi sincère, les parties III et IV du Léviathan ont souvent été délaissées par les commentateurs. Cet ... [more ▼]

Qu'elles soient considérées comme une tentative de légitimation hypocrite ou comme une attestation de foi sincère, les parties III et IV du Léviathan ont souvent été délaissées par les commentateurs. Cet ouvrage propose de réaffirmer l'importance des ces parties théologiques en leur conférant un sens nouveau. Dépassant l'opposition entre lecture séculière et lecture religieuse, il présente une interprétation de la théorie hobbesienne qui s'attache moins à déterminer les croyances personnelles de Hobbes qu'à déceler les effets pratiques de son discours. Selon l'auteur, c'est un projet politique annonciateur des Lumières qui oriente l'ensemble du Léviathan : émanciper la multitude d'un imaginaire théologico-politique corrompu et des craintes aliénantes qu'il produit. Dans cette perspective, la critique de la superstition et la réforme de l'imaginaire religieux, objet des deux dernières parties du traité, s'avèrent un préalable indispensable à la révolution intellectuelle que constitue la théorie de l'Etat. Dès lors, le Léviathan ne peut plus se voir réduit à une simple théorie de la souveraineté, mais doit aussi être considéré comme un ouvrage de réflexion critique sur l'imaginaire politico-religieux de son époque : il dispense un savoir iconoclaste et émancipateur dont la diffusion est en soi un acte politique. [less ▲]

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See detailChanges in the enantiomeric distribution of selected volatile constituents of Mentha pulegium L. powders caused by hot water treatment
Brokl, Michal ULg; Flores, G.; Blanch, G. P. et al

in Journal of Agricultural and Food Chemistry (2006), 54(23), 8836-8841

The variation, in general, of the composition of the aromatic fraction and, in particular, of the enantiomeric composition of certain chiral volatile compounds of commercial Mentha pulegium L. powders ... [more ▼]

The variation, in general, of the composition of the aromatic fraction and, in particular, of the enantiomeric composition of certain chiral volatile compounds of commercial Mentha pulegium L. powders caused by boiling water was evaluated. A comparison between the volatile profile of the studied herbs demonstrated that most M. pulegium L. samples contained high proportions of Mentha piperita L., even when this information was not specified on the label. Likewise, substantial changes in the volatile fraction of the infusions with respect to the composition of the original plant used in their preparation were found. The enantiomeric composition of some chiral compounds of the dried plant material, particularly limonene, was modified by adding hot water, whereas others were kept invariable. The results shown in this work reflect the need for the control of the composition of commercial powders and brews of M. pulegium L. to ensure their correct application. [less ▲]

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See detailFuture preventive therapy: are there promising drug targets
Schoenen, Jean ULg

in Headache Currents (2006), 3

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See detailResults of a whole-genome quantitative trait locus scan for growth, carcass composition and meat quality in a porcine four-way cross.
Harmegnies, N.; DAVIN, Fabienne ULg; DE SMET, Samantha ULg et al

in Animal Genetics (2006), 37(6), 543-53

A whole-genome quantitative trait locus (QTL) scan for 31 phenotypes related to growth, carcass composition and meat quality was conducted using 1187 progeny of a commercial four-way cross. Animals were ... [more ▼]

A whole-genome quantitative trait locus (QTL) scan for 31 phenotypes related to growth, carcass composition and meat quality was conducted using 1187 progeny of a commercial four-way cross. Animals were genotyped for 198 microsatellite markers that spanned the entire porcine genome. QTL analysis was conducted to extract information from paternal and maternal meioses separately using a rank-based nonparametric approach for half-sib designs. Nine QTL exceeded genome-wide significance: one QTL affecting growth (average daily gain on SSC1), two QTL influencing carcass composition (fatness on SSC3 and muscle mass on SSC15) and six QTL influencing meat quality (tenderness on SSC4 and SSC14; colour on SSC5, SSC6 and SSCX; and conductivity on SSC16). All but one of these coincided with previously reported QTL. In addition, we present evidence for 78 suggestive QTL with a combined false discovery rate of 40%. [less ▲]

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See detailNonaqueous capillary electrophoresis method for the enantiomeric purity determination of S-timolol using heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin: validation using the accuracy profile strategy and estimation of uncertainty.
Marini Djang'Eing'A, Roland ULg; Servais, Anne-Catherine ULg; Rozet, Eric ULg et al

in Journal of Chromatography. A (2006), 1120(1-2), 102-11

Nonaqueous capillary electrophoresis (NACE) was successfully applied to the enantiomeric purity determination of S-timolol maleate using heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin (HDMS-beta-CD ... [more ▼]

Nonaqueous capillary electrophoresis (NACE) was successfully applied to the enantiomeric purity determination of S-timolol maleate using heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin (HDMS-beta-CD) as chiral selector. With a background electrolyte made up of a methanolic solution of 0.75 M formic acid, 30 mM potassium camphorsulfonate and containing 30 mM HDMS-beta-CD, the determination of 0.1% of R-timolol in S-timolol could be performed with an enantiomeric resolution of 8.5. Pyridoxine was selected as internal standard. The NACE method was then fully validated by applying a novel strategy using accuracy profiles. It is based on beta-expectation tolerance intervals for the total measurement error which includes trueness and intermediate precision. The uncertainty of measurements derived from beta-expectation tolerance intervals was estimated at each concentration level of the validation standards. To confirm the suitability of the developed and validated method, several real samples of S-timolol maleate containing R-timolol maleate at different concentrations were analysed and the results were compared to those obtained by liquid chromatography. [less ▲]

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See detailFeasibility of STAP for passive GSM-based radar
Neyt, Xavier; Raout, J.; Kubika, Virginie et al

Conference (2006)

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See detailExtending postgrafting cyclosporine decreases the risk of severe graft-versus-host disease after nonmyeloablative hematopoietic cell transplantation
Burroughs, Lauri; Mielcarek, Marco; Leisenring, Wendy et al

in Transplantation (2006), 81(6), 818-25

BACKGROUND: It is unknown whether the duration of systemic immunosuppressive treatment after allogeneic nonmyeloablative hematopoietic cell transplantation (HCT) might influence the incidence, severity ... [more ▼]

BACKGROUND: It is unknown whether the duration of systemic immunosuppressive treatment after allogeneic nonmyeloablative hematopoietic cell transplantation (HCT) might influence the incidence, severity, timing, and/or corticosteroid-responsiveness of graft-versus-host disease (GVHD). METHODS: We retrospectively analyzed outcomes among 185 patients with hematologic malignancies who were given grafts from HLA-matched related donors following conditioning with 2 Gy total body irradiation alone or in combination with fludarabine between December 1998 and March 2003. Postgrafting immunosuppression consisted of mycophenolate mofetil (days 0-27) in combination with 3 different cyclosporine (CSP) regimens: taper from (A) days 35 to 56 (n=107), (B) days 56 to 77 (n=35), and (C) days 56 to 180 (n=43). RESULTS: The overall incidences of grades II-IV and III-IV acute GVHD, and extensive chronic GVHD were 52%, 13%, and 56%, respectively. The duration of CSP prophylaxis did not significantly influence the overall rate of acute GVHD (grade II-IV), extensive chronic GVHD, or non-relapse mortality. However, prolonged administration of CSP (group C) was associated with a significantly decreased hazard of grades III-IV acute GVHD (HR 0.2, 95% CI [0.04, 0.9]) and with an increased likelihood of discontinuing all systemic immunosuppression (HR 2.4, 95% CI [1.1, 5.2]) when compared to the shortest course of CSP (group A). CONCLUSION: Longer CSP duration decreased the risk of severe GVHD and increased the likelihood of discontinuing all systemic immunosuppression after nonmyeloablative HCT with HLA-matched related grafts. [less ▲]

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See detailNumerical modelling of coupled poromechanics processes
Charlier, Robert ULg; Laloui, Liesse; Collin, Frédéric ULg

in Revue Européenne de Génie Civil (2006), 10(6-7), 669-702

This paper is the basis for a course dedicated to geomechanics for energy production. A number of different coupling are discussed, with respectively the fluid flow (saturated and unsaturated) and the ... [more ▼]

This paper is the basis for a course dedicated to geomechanics for energy production. A number of different coupling are discussed, with respectively the fluid flow (saturated and unsaturated) and the thermal transfers in deformable porous media. Eventually some aspects on the numerical modelling with the finite element method are discussed. [less ▲]

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See detailRecension de: Denis Seron, Objet et signification. Matériaux phénoménologiques pour la théorie du jugement, Paris, Vrin, 2003
Dewalque, Arnaud ULg

in Revue Internationale de Philosophie (2006), 2006(2), 254-259

De Mill à Husserl, en passant par Kant ou Brentano, la philosophie moderne semble s’appuyer, de façon explicite ou non, sur une double équation qui témoigne de l’importance accordée à la problématique du ... [more ▼]

De Mill à Husserl, en passant par Kant ou Brentano, la philosophie moderne semble s’appuyer, de façon explicite ou non, sur une double équation qui témoigne de l’importance accordée à la problématique du jugement. D’une part : être, c’est être l’objet d’un jugement. Et d’autre part : connaître, c’est juger. Guidée par ces deux idées, l’étude de Denis Seron montre que la théorie du jugement ne se limite nullement à une discipline spéciale, mais est plutôt appelée à constituer ce qu’on pourrait nommer, après Kant, un « tribunal de la raison », dont le pouvoir de légiférer – la fonction critique au sens le plus strict du terme – s’exerce aussi bien dans le domaine de la théorie de l’objet (ontologie formelle) que dans celui de la théorie de la connaissance. [less ▲]

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See detailFrom an architectural sketch to feasible structural systems
Mora, Rodrigo; Juchmes, Roland ULg; Rivard, Hugues et al

in Gero, John, S.; Goel, Ashok K. (Eds.) Proceedings of the Second International Conference on Design Computing and Cognition (2006)

The goal of this research is to propose an integrated approach to incorporate structural engineering concerns into architectural schematic designs for timely and well-informed decision making. This is ... [more ▼]

The goal of this research is to propose an integrated approach to incorporate structural engineering concerns into architectural schematic designs for timely and well-informed decision making. This is done through a platform that is based on two software prototypes, EsQUIsE for capturing and interpreting architectural sketches, and StAr for assisting engineers during conceptual structural design. An integrated information model is provided for communication. Given the dissimilar “quality” of the information managed by both prototypes, sketch interpretation mechanisms are also required to “tune-up” communications for bringing the sketch to a precise structural engineering definition. As a result, the engineer can propose feasible structural systems earlier than usual. [less ▲]

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See detailEnigmatic Givetian palynomorphs
Steemans, Philippe ULg

Report (2006)

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See detailPrevalence and sources of Campylobacter spp. contamination in free-range broiler production in Belgium
Vandeplas, Sabrina ULg; Dubois Dauphin, Robin ULg; Beckers, Yves ULg et al

in World's Poultry Science Journal (2006), 62(supplément), 557

An one year epidemiological study was carried out between February 2005 and January 2006 in Belgium to assess the Campylobacter prevalence in free-range broiler production. Three successive broiler flocks ... [more ▼]

An one year epidemiological study was carried out between February 2005 and January 2006 in Belgium to assess the Campylobacter prevalence in free-range broiler production. Three successive broiler flocks on 6 belgian farms were investigated for the presence of Campylobacter ssp. during the rearing period. Each flock was visited four times, before and after the outdoor rearing period. During each visit, samples were taken in the broiler houses (litter, cecal droppings, water-lines, feed, entrance premises) as well as from the outer rearing environment (open-air range). Conventional microbiological methods combined with biochemical tests were used for the Campylobacter detection, species identification and isolation. Campylobacter prevalence was very high in free-range broiler production during the experimental period. C. jejuni is the main species isolated from all contaminated samples, while mixed C. jejuni/C. coli infections sometimes occured. Contamination of the broiler flocks was increased in summer/autumn, with a 100% flocks contamination, whereas only 4 (66.7%) and 3 (50%) of the flocks became Campylobacter positive in spring and winter respectively, at the end of the rearing period. Moreover, about 53.8% of contaminated flocks were infected with Campylobacter before chicks have access to the open-air range. In 69.2% of the Campylobacter-positive flocks, the open-air range soil belonged partly of fully to environmental samples found to be Campylobacter-positive before flock infection. The other potential sources of infection were delivery tray, entrance premises floor and water-lines. The access to an open-air range seems to be an important way of contamination of broilers because Campylobacter prevalence in the flocks increased after going out. [less ▲]

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See detailDynamics of spontaneous ventricular fibrillation in acutely ischemic pigs
Desaive, Thomas ULg; Janssen, Nathalie ULg; Péters, F. et al

in Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology (2006), 8 (supplement 1)

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See detailTNFa and IKKb-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKg and NF-kB activation
Bonif, Marianne; Meuwis, Marie-Alice ULg; Close, Pierre ULg et al

in Biochemical Journal (2006), 394

Pro-inflammatory cytokines trigger signalling cascades leading to NF-kappaB (nuclear factor-kappaB)-dependent gene expression through IKK [IkappaB (inhibitory kappaB) kinase]-dependent phosphorylation and ... [more ▼]

Pro-inflammatory cytokines trigger signalling cascades leading to NF-kappaB (nuclear factor-kappaB)-dependent gene expression through IKK [IkappaB (inhibitory kappaB) kinase]-dependent phosphorylation and subsequent degradation of the IkappaB proteins and via induced phosphorylation of p65. These signalling pathways rely on sequentially activated kinases which are assembled by essential and non-enzymatic scaffold proteins into functional complexes. Here, we show that the pro-inflammatory cytokine TNFalpha (tumour necrosis factor alpha) promotes TANK [TRAF (TNF receptor-associated factor) family member associated NF-kappaB activator] recruitment to the IKK complex via a newly characterized C-terminal zinc finger. Moreover, we show that TANK is phosphorylated by IKKbeta upon TNFalpha stimulation and that this modification negatively regulates TANK binding to NEMO (NF-kappaB essential modulator). Interestingly, reduced TANK expression by RNA interference attenuates TNFalpha-mediated induction of a subset of NF-kappaB target genes through decreased p65 transactivation potential. Therefore the scaffold protein TANK is required for the cellular response to TNFalpha by connecting upstream signalling molecules to the IKKs and p65, and its subsequent IKKbeta-mediated phosphorylation may be a mechanism to terminate the TANK-dependent wave of NF-kappaB activation. [less ▲]

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