References of "2006"
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See detailEnvironmental hazards and the skin.
Pierard, Claudine ULg; Quatresooz, Pascale ULg; Berardesca, E. et al

in European Journal of Dermatology (2006), 16(3), 322-4

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See detailNumerical simulation of impedance and admittance of OLEDs
Nguyen, Ngoc Duy ULg; Schmeits, Marcel

in Physica Status Solidi : A. Applications and Materials Science (2006), 203

The electrical characteristics of organic light-emitting devices are calculated for the dc and ac regimes by numerically solving the basic semiconductor equations under steady-state and small-signal ... [more ▼]

The electrical characteristics of organic light-emitting devices are calculated for the dc and ac regimes by numerically solving the basic semiconductor equations under steady-state and small-signal conditions. For a given structure, the dc and ac electric potential and electric field, the electron and hole concentrations, as well as the different components of the current density are obtained as function of the one-dimensional spatial coordinate. This approach allows a detailed microscopic description of the dependencies of these quantities on the applied steady-state voltage V0 and the frequency of the modulating voltage. The final output consists in the frequency-dependent complex admittance and impedance of the device, the real and imaginary parts of which are the experimentally-available data. As a typical example, we show the results for a two-layer structure where α-NPD is the hole-transporting material and Alq3 the electron-transporting material. The anode is made of ITO and Al/LiF composes the cathode. The admittance and impedance curves, yielded by the numerical simulation as functions of the modulation frequency, are fitted by an equivalent electrical circuit, the elements of which are resistances and capacitances. The number of com- ponents depends on the structure composition and on the applied steady-state voltage. We show that each element can be associated with a particular region of the device. This allows to correlate the dependence of each feature of the admittance and impedance curves with one or several parameters describing the ma- terial system. Such an analysis can be useful for the inverse approach, where, starting from measurements of the electrical ac characteristics, the aim is to get information on the microscopic mechanisms which contribute to the electrical conduction of the device. [less ▲]

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See detailThe use of various gas chromatography and mass spectrometry techniques for human biomonitoring studies
Patterson, Donald G.; Welch, S. M.; Focant, Jean-François ULg et al

in Organohalogen Compounds (2006), 68

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See detailPeroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis
Relic, Biserka ULg; Benoit, Valerie; Franchimont, Nathalie et al

in Journal of Biological Chemistry (2006), 281(32), 597-604

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a central role in whole body metabolism by regulating adipocyte differentiation and energy storage. Recently, however, PPAR-gamma has ... [more ▼]

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a central role in whole body metabolism by regulating adipocyte differentiation and energy storage. Recently, however, PPAR-gamma has also been demonstrated to affect proliferation, differentiation, and apoptosis of different cell types. As we have previously shown that BAY 11-7085-induced synovial fibroblast apoptosis is prevented by PPAR-gamma agonist 15d-PGJ2; the expression of PPAR-gamma in these cells was studied. Both PPAR-gamma1 and PPAR-gamma2 isoforms were cloned from synovial fibroblast RNA, but only PPAR-gamma1 was detected by Western blot, showing constitutive nuclear expression. Within minutes of BAY 11-7085 treatment, a PPAR-gamma1-specific band was shifted into a form of higher mobility, suggesting dephosphorylation, as confirmed by phosphatase treatment of cell extracts. Of interest, BAY 11-7085-induced PPAR-gamma1 dephosphorylation was followed by PARP and caspase-8 cleavage as well as by PPAR-gamma1 protein degradation. PPAR-gamma1 dephosphorylation was followed by the loss of PPAR-DNA binding activity ubiquitously present in synovial fibroblast nuclear extracts. Unlike the phosphorylated form, dephosphorylated PPAR-gamma1 was found in insoluble membrane cell fraction and was not ubiquitinated before degradation. PPAR-gamma1 dephosphorylation coincided with ERK1/2 phosphorylation that accompanies BAY 11-7085-induced synovial fibroblasts apoptosis. 15d-PGJ2, PGD2, and partially UO126, down-regulated ERK1/2 phosphorylation, protected cells from BAY 11-7085-induced apoptosis, and reversed both PPAR-gamma dephosphorylation and degradation. Furthermore, PPAR-gamma antagonist BADGE induced PPAR-gamma1 degradation, ERK1/2 phosphorylation, and synovial fibroblasts apoptosis. The results presented suggest an anti-apoptotic role for PPAR-gamma1 in synovial fibroblasts. Since apoptotic marker PARP is cleaved after PPAR-gamma1 dephosphorylation but before PPAR-gamma1 degradation, dephosphorylation event might be enough to mediate BAY 11-7085-induced apoptosis in synovial fibroblasts. [less ▲]

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See detailApport de la granulométrie laser dans la caractérisation physique des fillers calcaires
Michel, Frédéric ULg; Courard, Luc ULg

in Arliguie, Ginette (Ed.) Compte-rendu des Journées Scientifiques du (RF)2B (2006)

On assiste actuellement en Belgique à une baisse importante de la production des matériaux habituellement employés comme additions dans les composites à matrice cimentaire (cendres volantes, laitier de ... [more ▼]

On assiste actuellement en Belgique à une baisse importante de la production des matériaux habituellement employés comme additions dans les composites à matrice cimentaire (cendres volantes, laitier de haut fourneau). Pour faire face à ce problème, un vaste programme de recherche a été mis sur pied dans le but d’évaluer le potentiel de valorisation de fillers calcaires, de production wallonne, dans ce secteur. Ce papier traite des techniques utilisées pour caractériser de manière physique les fillers calcaires. Une étude paramétrique a permis de définir les conditions optimales de mesure de leur granulométrie par diffraction laser. Les résultats ont été comparés à ceux obtenus par la technique plus classique de tamisage en voie humide. La surface spécifique des poudres a également été mesurée par adsorption d’azote (méthode BET), par perméabilité (Blaine) et calculée à partir des résultats de la diffraction, via le diamètre de Sauter. [less ▲]

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See detailThe prospects of detecting exo-planets with the Ground-based European Nulling Interferometer Experiment (GENIE)
den Hartog, R.; Absil, Olivier ULg; Gondoin, P. et al

in Aime, C.; Vakili, F. (Eds.) Direct Imaging of Exoplanets: Science & Techniques (2006)

The European Space Agency's Darwin and NASA's Terrestrial Planet Finder (TPF) are among the most challenging space science missions ever considered. Their principal objective is to detect Earth-like ... [more ▼]

The European Space Agency's Darwin and NASA's Terrestrial Planet Finder (TPF) are among the most challenging space science missions ever considered. Their principal objective is to detect Earth-like planets around nearby stars and to characterize their atmospheres. Darwin and TPF-I are currently conceived as nulling interferometers with free-flying telescopes. Within the frame of the Darwin program, the ESA and the European Southern Observatory (ESO), supported by European industries and scientific institutes, have performed two parallel Phase A studies of a ground-based nulling interferometry experiment (GENIE) at the site of ESO's Very Large Telescope Interferometer (VLTI) in Paranal, Chile. GENIE will demonstrate several key technologies required for the Darwin mission. Its science objectives include the detection and characterization of dust disks and low-mass companions around nearby stars. These studies have established detailed instrumental designs, in which GENIE will operate in the L' band around 3.8 microns as a single Bracewell nulling or constructive interferometer, using either two Auxiliary or two Unit Telescopes. The studies were supported by detailed numerical simulations which indicated the possibility of detection and low-resolution spectroscopy in nulling mode of extra-solar giant planets (EGPs) with atmospheric temperatures down to 700 K, provided that a proper calibration of instrumental effects is applied. Detection of circumstellar exo-zodiacal (EZ) dust clouds is possible down to 0.5 mJy, with interesting prospects for the characterization of planet-forming disks. [less ▲]

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See detailMechanochemistry: targeted delivery of single molecules
Duwez, Anne-Sophie ULg; Cuenot, Stéphane; Jérôme, Christine ULg et al

in Nature Nanotechnology (2006), 1

The use of scanning probe microscopy-based techniques to manipulate single molecules(1) and deliver them in a precisely controlled manner to a specific target represents a significant nanotechnological ... [more ▼]

The use of scanning probe microscopy-based techniques to manipulate single molecules(1) and deliver them in a precisely controlled manner to a specific target represents a significant nanotechnological challenge(2,3). The ultimate physical limit in the design and fabrication of organic surfaces can be reached using this approach. Here we show that the atomic force microscope (AFM), which has been used extensively to investigate the stretching of individual molecules(4-12), can deliver and immobilize single molecules, one at a time, on a surface. Reactive polymer molecules, attached at one end to an AFM tip, are brought into contact with a modified silicon substrate to which they become linked by a chemical reaction. When the AFM tip is pulled away from the surface, the resulting mechanical force causes the weakest bond - the one between the tip and polymer - to break. This process transfers the polymer molecule to the substrate where it can be modified by further chemical reactions. [less ▲]

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See detailLe capital social : une introduction
Jacquemain, Marc ULg

in Houard, Jean; Jacquemain, Marc (Eds.) Capital social et dynamique régionale (2006)

The text presents the main articulations within social capital theory : formal and informal, thin and thick, bonding, bridging and linking social capital, with a word about the theory of the "dark side ... [more ▼]

The text presents the main articulations within social capital theory : formal and informal, thin and thick, bonding, bridging and linking social capital, with a word about the theory of the "dark side". It also adresses the question of what is at stake in this theory. Then, the text introduces the main themes of the book : the links between social capital and social cohesion, gender, education, media, entrepeneurship [less ▲]

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See detailEffect of Beclomethasone Dipropionate and Dexamethasone Isonicotinate on Lung Function, Bronchoalveolar Lavage Fluid Cytology, and Transcription Factor Expression in Airways of Horses with Recurrent Airway Obstruction
Couetil, L.; Art, Tatiana ULg; de Moffarts, Brieuc et al

in Journal of Veterinary Internal Medicine (2006), 20

Glucocorticoid (GC) therapy is recognized to be effective for the treatment of recurrent airway obstruction (RAO) in horses. Anti-inflammatory properties of GC are thought to be mediated by suppression of ... [more ▼]

Glucocorticoid (GC) therapy is recognized to be effective for the treatment of recurrent airway obstruction (RAO) in horses. Anti-inflammatory properties of GC are thought to be mediated by suppression of inflammatory gene expression via inhibition of transcription factors such as nuclear factor-kB (NF-kB) and activator protein-1 (AP-1). The purpose of this study was to evaluate the effect of low-dose inhaled beclomethasone dipropionate and injectable dexamethasone 21- isonicotinate on clinical signs, pulmonary function, airway cytology, and activity of NF-kB and AP-1 in bronchial cells of RAO-affected horses. Seven horses with RAO were exposed to moldy hay until they developed airway obstruction on 3 separate occasions. In a crossover design, they were then treated with a placebo (injection on day 1), inhaled beclomethasone (500 mg q12h for 10 days), or dexamethasone (0.06 mg/kg, IM on day 1) and monitored for 10 days. Pulmonary function, bronchoalveolar lavage fluid cytology, and NF-kB and AP-1 activity in bronchial brushing cells were measured before (day 1) and after treatment (day 10). Treatment with beclomethasone resulted in significantly improved pulmonary function of RAOaffected horses compared with placebo and dexamethasone treatments. However, none of the treatments had an effect on bronchoalveolar lavage fluid cytology or NF-kB and AP-1 activity. These findings reveal that, in a model of severe RAO, the benefits of low-dose inhaled beclomethasone on pulmonary function are not accompanied by a decrease in airway inflammatory cells or a suppression of transcription factors NF-kB and AP-1 DNA-binding activity. [less ▲]

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See detailLC method for the determination of R-timolol in S-timolol maleate: Validation of its ability to quantify and uncertainty assessment.
Marini Djang'Eing'A, Roland ULg; Chiap, Patrice ULg; Boulanger, Bruno ULg et al

in Talanta (2006), 68(4), 1166-1175

This article presents the validation results of a chiral liquid chromatographic (LC) method previously developed for the quantitative determination of R-timolol in S-timolol maleate samples. A novel ... [more ▼]

This article presents the validation results of a chiral liquid chromatographic (LC) method previously developed for the quantitative determination of R-timolol in S-timolol maleate samples. A novel validation strategy based on the accuracy profiles was used to select the most appropriate regression model, to assess the method accuracy within well defined acceptance limits and to determine the limits of quantitation as well as the concentration range. The validation phase was completed by the investigation of the risk profiles of various acceptable regression models in order to ensure the risk of obtaining the future measurements outside the acceptance limits fixed a priori. On the other hand, the present paper also shows how data used in this validation approach can be used to estimate the measurement uncertainty. The uncertainty derived from beta-expectation tolerance interval (sigma(Tol)(2)), which is equal to the uncertainty of measurements as well as the expanded uncertainty (U(x)) using a coverage factor k=2 was estimated. The uncertainty estimates obtained from validation data were finally compared with those obtained from interlaboratory and robustness studies. [less ▲]

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See detailL'analyse qualitative dans les recherches en éducation : Des pratiques de recherche aux critères de qualité.
Paquay, L.; Crahay, Marcel ULg; De Ketele, J. M.

Book published by De Boeck & Larcier (2006)

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See detailEffect of rimonabant on quality of life in overweight/obese patients
Kolotkin, R. L.; Crosby, R. D.; Scheen, André ULg et al

in Value in Health (2006), 9(3, MAY-JUN), 92

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See detailStudy of the role of histone deacetylases in myofibroblastic differenciation
Glénisson, Wendy; Waltregny, David ULg; Castronovo, Vincenzo ULg

Scientific conference (2006)

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See detailA Fourier-Based Solver for 3-D High-Frequency Surface Scattering Problems
Geuzaine, Christophe ULg

in Proceedings of the 12th IEEE Conference on Electromagnetic Field Computation, CEFC 2006 (2006)

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See detailMétalangage et épistémologie
Badir, Sémir ULg

in Horizon sémiologie (2006)

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See detailAtypical symptoms of GORD in Belgium: Epidemiological features, current management and open label treatment with 40 mg esomeprazole for one month
Louis, Edouard ULg; Jorissen, P.; Bastens, B. et al

in Acta Gastro-Enterologica Belgica (2006), 69(2, Apr-Jun), 203-208

Frequency of atypical symptoms in patients suffering from gastro-oesophageal reflux disease (GORD) is not well known, and the optimal management of such symptoms has not been well established. Our aims ... [more ▼]

Frequency of atypical symptoms in patients suffering from gastro-oesophageal reflux disease (GORD) is not well known, and the optimal management of such symptoms has not been well established. Our aims were to set up an observatory of these atypical symptoms of GORD in Belgium and to study the efficacy of one month treatment with esomeprazole 40 mg. Patients and methods : Gastroenterologists; participating in this observational survey were asked to register every new outpatient with symptoms of GORD during a period of 20 consecutive working days. All patients who reported predominant presence of atypical manifestations of GORD were documented and characterized more in detail. In patients with dominant chest pain or ENT symptoms, a treatment with esomeprazole 40 mg daily during 4 weeks was proposed. Results : 90 gastroenterologists included 2864 patients consulting for symptoms suggestive of GORD, including 776 (27.1%) with dominant atypical symptoms. Endoscopy (performed in 2800 patients) showed significantly less oesophagitis in atypical than in typical GORD patients (68% vs. 81.1%; P < 0.0001). Management of atypical GORD patients appeared to be very heterogeneous. Overall 516/776 patients were included in the open phase of treatment with esomeprazole 40 mg, but data for analysis are only available in 228 patients. After one month, symptoms had disappeared in 57.1% and significantly improved in 26.6%. Conclusion : Atypical GORD represents a large number of consultations in gastroenterology in Belgium. It is associated with less endoscopic lesions than typical GORD. Its management is heterogeneous reflecting the lack of guidelines on this topic. Response rate after esomeprazole 40 mg for one month in this open uncontrolled trial was high. This result warrants confirmation in a placebo-controlled trial. [less ▲]

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See detailInfluence of human activities on the metallic trace elements status in soils
Colinet, Gilles ULg; Bizoux, Jean-Philippe ULg; Bock, Laurent ULg

Conference (2006)

The total concentrations of trace elements in soils results from natural and anthropic factors. Knowledge of natural distribution (e.g. bio-geochemical background) helps assessing the impacts of human ... [more ▼]

The total concentrations of trace elements in soils results from natural and anthropic factors. Knowledge of natural distribution (e.g. bio-geochemical background) helps assessing the impacts of human activities in terms of contaminations. But the processes generated by the modifications of the soil environment may also affect the form of a trace element, that is its distribution through various pools. We investigated the chemical speciation of some metallic trace elements (Cu, Zn, Cr, Ni, Pb, Co, Cd) in soils from various land-use environment: “natural” soils under forest, “typical” cultivated soils, kitchen-garden soils, soils developped on geogenic anomalies and on contaminated areas. The analysis protocol aims at identifying different pools from their reaction to various extraction phases, ordered by increasing intensity in a single sequence. The different fractions are so-called soluble, linked to carbonates, to organic matter, to manganese oxides, to weakly cristallized Fe-Al oxides, to well-cristallized oxides, and residual. The “available” and total fractions have also been measured. The results stress the fact that the comparisons are difficult from one situation to another because each one represents a particular case of human activity without a common logic. The relationships with the classical pedological parameters are therefore difficult to generalize. However some relationships between elements have been found inside the various types of land use, which could be usefull in the risk assesment of transfers from soils to plants. [less ▲]

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See detailLe Paléolithique supérieur de Belgique. Recherches 2001-2005
Otte, Marcel ULg; Noiret, Pierre ULg

in Noiret, Pierre (Ed.) Le Paléolithique supérieur européen. Bilan quinquennal 2001-2006 (2006)

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See detailEffect of the exotic invasive plant Solidago gigantea on soil phosphorus status
Chapuis-Lardy, L.; Vanderhoeven, SONIA ULg; Dassonville, N. et al

in Biology & Fertility of Soils (2006), 42(6), 481-489

Invasions by exotic plant species can modify biogeochemical cycles and soil properties. We tested whether invasion by early goldenrod (Solidago gigantea, Asteraceae) modifies soil phosphorus pools at ... [more ▼]

Invasions by exotic plant species can modify biogeochemical cycles and soil properties. We tested whether invasion by early goldenrod (Solidago gigantea, Asteraceae) modifies soil phosphorus pools at three sites in Belgium. Aboveground phytomass and soil samples (0-10 cm) were collected in early goldenrod patches and in adjacent, uninvaded, grassland vegetation. Soil P fractions varied between the three sites in line with corresponding differences in organic matter, carbonate and clay contents. In addition to site-specific impacts, plots invaded by goldenrods generally had higher concentrations of labile P [i.e. resin-extractable inorganic P (Pi) and bicarbonate-extractable Pi and organic P]. Soil CO2 release and alkaline and acid phosphomonoesterase activities were also higher in invaded plots, suggesting that the increase in labile Pi was due to enhanced mineralization. Phosphorus uptake by vegetation was 1.7-2.1 times higher in invaded plots, mostly due to the higher annual yield of S. gigantea. Altogether, the results indicate that S. gigantea enhances P turnover rates in invaded ecosystems. [less ▲]

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