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See detailTNFa and IKKb-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKg and NF-kB activation
Bonif, Marianne; Meuwis, Marie-Alice ULg; Close, Pierre ULg et al

in Biochemical Journal (2006), 394

Pro-inflammatory cytokines trigger signalling cascades leading to NF-kappaB (nuclear factor-kappaB)-dependent gene expression through IKK [IkappaB (inhibitory kappaB) kinase]-dependent phosphorylation and ... [more ▼]

Pro-inflammatory cytokines trigger signalling cascades leading to NF-kappaB (nuclear factor-kappaB)-dependent gene expression through IKK [IkappaB (inhibitory kappaB) kinase]-dependent phosphorylation and subsequent degradation of the IkappaB proteins and via induced phosphorylation of p65. These signalling pathways rely on sequentially activated kinases which are assembled by essential and non-enzymatic scaffold proteins into functional complexes. Here, we show that the pro-inflammatory cytokine TNFalpha (tumour necrosis factor alpha) promotes TANK [TRAF (TNF receptor-associated factor) family member associated NF-kappaB activator] recruitment to the IKK complex via a newly characterized C-terminal zinc finger. Moreover, we show that TANK is phosphorylated by IKKbeta upon TNFalpha stimulation and that this modification negatively regulates TANK binding to NEMO (NF-kappaB essential modulator). Interestingly, reduced TANK expression by RNA interference attenuates TNFalpha-mediated induction of a subset of NF-kappaB target genes through decreased p65 transactivation potential. Therefore the scaffold protein TANK is required for the cellular response to TNFalpha by connecting upstream signalling molecules to the IKKs and p65, and its subsequent IKKbeta-mediated phosphorylation may be a mechanism to terminate the TANK-dependent wave of NF-kappaB activation. [less ▲]

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See detailBiocontrol of blue mold on apple fruits by Aureobasidium pullulans (strain Ach 1-1): in vitro and in situ evidence for the possible involvement of competition for nutrients.
Bencheqroun, S Krimi; Bajji, M.; Massart, Sébastien ULg et al

in Communications in agricultural and applied biological sciences (2006), 71(3 Pt B), 1151-1157

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See detailHomenaje conmemorativo a Manuel Sacristán
Ceballos Viro, Alvaro ULg

in Revista de Hispanismo Filosófico (2006)

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See detailLe sujet de l'histoire
Denis, Benoît ULg

in Durand, Pascal (Ed.) L'écrivain et son double. Hubert Nyssen (2006)

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See detailUn prisme ou une rose des vents des finalités et caractéristiques d'un Dispositif d'Evaluation (DEA)
Leclercq, Dieudonné ULg

Learning material (2006)

According to the prism through which performances are observed (measured and judged), the resulting (numerical or qualitative) pictures that reflect them may vary greatly. A prism has several dimensions ... [more ▼]

According to the prism through which performances are observed (measured and judged), the resulting (numerical or qualitative) pictures that reflect them may vary greatly. A prism has several dimensions. It can also be spoken of a compass of several bipolar dimensions (directions) represnted by nails. A dozen of them are presented and illustrated. [less ▲]

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See detailImpact of Prosthesis-Patient Mismatch on Survival After Mitral Valve Replacement.
Magne, Julien ULg; Mathieu, P; Dumesnil, JG et al

Conference (2006)

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See detailDiagnosing entrapment neuropathies: probes and magnets instead of electrodes and needles?
MAERTENS DE NOORDHOUT, Alain ULg

in Clinical Neurophysiology (2006), 117(3), 484-5

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See detailGeo-electrical data fusion by stochastic co-conditioning simulations for delineating groundwater protection zones
Dassargues, Alain ULg

(2006)

In hydrogeology, advances in the delimitation of protection zones are made by the use of stochastic simulations integrating all available data. In practice, due to the few available measurements of the ... [more ▼]

In hydrogeology, advances in the delimitation of protection zones are made by the use of stochastic simulations integrating all available data. In practice, due to the few available measurements of the main parameters (hard data), it is very useful to integrate several secondary properties of the media as indirect data (soft data) to reduce the uncertainty of the results. In aquifers, most of the solute spreading is governed by the hydraulic conductivity (K) spatial variability, which is generally considered as the main uncertain parameter. A stochastic approach integrating hydraulic conductivity measurements (hard data), head observations and shallow electrical resistivity tomography (soft data) is presented. Results are discussed on a synthetic and on a practical case. It is shown in practice how the uncertainty of the well capture zone probability distribution (CaPD) can be reduced. Since geophysical data and head observations are easier to collect on the field then hydraulic conductivity measurements, they are generally more abundant. The methodology presented can even be used in real applications when little or no information is available about the hydraulic properties, through the conditioning on geophysical data and/or head observations. [less ▲]

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See detailReducing the uncertainty of hydrogeological parameters by co-conditional simulations: lessons from practical applications in aquifers and in low permeability layers
Dassargues, Alain ULg; Rentier, Céline; Huysmans, Marijke

in Calibration and Reliability in Groundwater Modelling: From Uncertainty to Decision Making (2006)

Stochastic simulation of aquifer heterogeneity is now often performed to provide a confidence interval of the modelled results for flow and solute transport problems. In practice, due to the few available ... [more ▼]

Stochastic simulation of aquifer heterogeneity is now often performed to provide a confidence interval of the modelled results for flow and solute transport problems. In practice, due to the few available measurements of the hydraulic conductivity (hard data), it is useful to integrate several other properties of the medium as indirect data (soft data). The additional conditioning obtained from the use of these secondary data allows reduction of the variance of the distribution and consequently decrease of the uncertainty of the results. This practice can also be extended to low permeability clay layers. For example, stochastic sequential simulation can be performed involving hydraulic conductivity values as hard data, and grain size measurements, electrical resistivity log, gamma ray log and a description of the lithology variation as soft data. However, other important properties can also be considered. The possible fracturing of clay strongly influences the flow and solute transport. On the other hand, in very low permeability media, diffusion can be considered as the dominant transport mechanism, so that heterogeneity in terms of the effective diffusion coefficient becomes important. Examples of application are summarized considering aquifers and low permeability clay layers. It clearly shows the great advantage of collecting multiple data sets of inter-correlated data on the same geological medium to be modelled. In high conductivity aquifers as well as in low permeability layers, this kind of additional conditioning obtained from various data is always useful when considering applications such as, among many others, well capture zones delineation, impact studies and geological confinement of wastes. [less ▲]

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See detailExtending postgrafting cyclosporine decreases the risk of severe graft-versus-host disease after nonmyeloablative hematopoietic cell transplantation
Burroughs, Lauri; Mielcarek, Marco; Leisenring, Wendy et al

in Transplantation (2006), 81(6), 818-25

BACKGROUND: It is unknown whether the duration of systemic immunosuppressive treatment after allogeneic nonmyeloablative hematopoietic cell transplantation (HCT) might influence the incidence, severity ... [more ▼]

BACKGROUND: It is unknown whether the duration of systemic immunosuppressive treatment after allogeneic nonmyeloablative hematopoietic cell transplantation (HCT) might influence the incidence, severity, timing, and/or corticosteroid-responsiveness of graft-versus-host disease (GVHD). METHODS: We retrospectively analyzed outcomes among 185 patients with hematologic malignancies who were given grafts from HLA-matched related donors following conditioning with 2 Gy total body irradiation alone or in combination with fludarabine between December 1998 and March 2003. Postgrafting immunosuppression consisted of mycophenolate mofetil (days 0-27) in combination with 3 different cyclosporine (CSP) regimens: taper from (A) days 35 to 56 (n=107), (B) days 56 to 77 (n=35), and (C) days 56 to 180 (n=43). RESULTS: The overall incidences of grades II-IV and III-IV acute GVHD, and extensive chronic GVHD were 52%, 13%, and 56%, respectively. The duration of CSP prophylaxis did not significantly influence the overall rate of acute GVHD (grade II-IV), extensive chronic GVHD, or non-relapse mortality. However, prolonged administration of CSP (group C) was associated with a significantly decreased hazard of grades III-IV acute GVHD (HR 0.2, 95% CI [0.04, 0.9]) and with an increased likelihood of discontinuing all systemic immunosuppression (HR 2.4, 95% CI [1.1, 5.2]) when compared to the shortest course of CSP (group A). CONCLUSION: Longer CSP duration decreased the risk of severe GVHD and increased the likelihood of discontinuing all systemic immunosuppression after nonmyeloablative HCT with HLA-matched related grafts. [less ▲]

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See detailREMOVAL OF PCDD/FS AND DL-PCBS FROM FISH OILS BY VOLATILISATION PROCEDURES
Carbonnelle, Sophie; Eppe, Gauthier ULg; Hellebosch, L. et al

in Organohalogen Compounds (2006)

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See detailMédias dominants et altermondialisme. De l’ouverture à la censure
Geuens, Geoffrey ULg

in Durand, Pascal; Hébert, Pierre; Mollier, Jean-Yves (Eds.) et al La censure de l’imprimé. Belgique, France, Québec et Suisse romande (XIXe et XXe siècles) - Actes du colloque international Censure et Imprimé (Université de Versailles, Saint-Quentin-en-Yvelines, 21-23 mai 2002) (2006)

Les débats médiatiques sur la mondialisation s’articulent autour de deux thèses apparemment antagonistes. Pour les partisans du libéralisme économique et les représentants des milieux d’affaires, il ... [more ▼]

Les débats médiatiques sur la mondialisation s’articulent autour de deux thèses apparemment antagonistes. Pour les partisans du libéralisme économique et les représentants des milieux d’affaires, il s’agit de condamner l’interventionnisme et le dirigisme politique dans le libre-jeu de l’économie de marché. Les chefs de file syndicaux et dirigeants réformistes de l’« altermondialisme », entendent, quant à eux, défendre, bec et ongles, l’idée d’un personnel politique victime de la bourse et des pressions de divers lobbies industriels et financiers. Dans les deux cas pourtant, on procède à une dissociation artificielle et trompeuse de l’économique et du politique. Cette représentation dominante de la mondialisation est à l’origine d’une censure, celle qui, derrière le paravent de l’Etat « victime » ou « bourreau » des marchés, refuse la parole aux critiques dénonçant les liens organiques entre pouvoirs économique, politique et médiatique. [less ▲]

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See detailCost-effective media for the rapid and high resolution of small DNA fragments using polyacrylamide-based electrophoresis
Negro, S. S.; Cloots, Rudi ULg; Gemmell, N. J.

in Molecular Ecology Notes (2006), 6(3), 609-612

Current Tris-based solutions for DNA electrophoresis produce a positive feedback loop between current and temperature at high voltage, resulting in long running times for the separation of even small DNA ... [more ▼]

Current Tris-based solutions for DNA electrophoresis produce a positive feedback loop between current and temperature at high voltage, resulting in long running times for the separation of even small DNA fragments. We optimized the separation of small DNA fragments (90-300 bp) in polyacrylamide-based electrophoresis at high voltages (200volts/cm) by substituting Tris with low concentration alkali salts (e.g. 1 mm LiCl and CsCl). These media reduced the heat produced during electrophoresis, enhanced the DNA fragment resolution, and allowed gels to be run at higher voltages, reducing gel running times by 25%. In addition, the elimination of Tris and EDTA from the buffer reduced material costs approximately 10-fold. © 2006 The Authors. [less ▲]

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See detailMichael Krüger: "Die Turiner Komödie". Mit einer literarischen Speisekarte
Küpper, Achim ULg

E-print/Working paper (2006)

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See detailEffect of excavation induced fractures on radionuclide migration through the Boom Clay (Belgium)
Huysmans, Marijke; Berckmans, Arne; Dassargues, Alain ULg

in Applied Clay Science (2006), 33(3-4), 207-218

In Belgium, the Boom Clay is being evaluated as a potential host formation for the disposal of high-level nuclear waste. In order to investigate this option, an underground research facility composed of ... [more ▼]

In Belgium, the Boom Clay is being evaluated as a potential host formation for the disposal of high-level nuclear waste. In order to investigate this option, an underground research facility composed of two access shafts and 200m of galleries was excavated. Excavation induced fractures were observed in a zone of approximately 1 m around the galleries. In this study, the potential effect of these fractures on radionuclide migration in the Boom Clay is investigated. Therefore, a hydrogeological model of the clay is built with a radionuclide source in the middle of the clay layer surrounded by different fracture configurations. Two types of fracture configurations are inserted in the model. The first type of fracture properties is drawn stochastically from the probability distributions of the properties of the fractures observed around previously excavated galleries. These fracture patterns are considered to be realistic although in this study it is conservatively assumed that no self-sealing occurs. The model is run for a large number of stochastically drawn fracture configurations and the results are compared to a model without fractures. These calculations show that the radionuclide fluxes through the clay are not significantly influenced by these fractures. For the second type of fracture configurations, the fracture properties are varied over a much larger range. Hypothetical fractures with much higher values of fracture extent, aperture, dip and frequency than observed are modeled, With these hypothetical fracture configurations, the critical values of the fracture parameters are determined that must be exceeded to have a significant effect on the radionuclide fluxes through the clay. These calculations show that the extent of the fractured zone has the largest effect on radionuclide migration. The other fracture parameters (aperture, spacing and dip) have a limited effect on the radionuclide fluxes. To obtain a total radionuclide flux through the lower clay boundary that is respectively 10%, 50% and 100% larger than without a fractured zone, the extent of the hypothetical fractured zone should be respectively 27.97 m, 43.86 m and 46.92 m. Such fractures are not expected to be generated by mechanical excavation in the Boom Clay. The obtained critical extent values of the hypothetical fractures are a factor 30 to 40 higher than the measured values of the extent of the excavation disturbed zone. These calculations thus indicate that it is very unlikely that the extent of the fractured zone around the galleries will be large enough to have a significant effect on the radionuclide fluxes through the Boom Clay. This conclusion is further supported by the conservative assumption that no self-sealing occurs. These calculations can function as a preliminary robustness test in ongoing safety analysis studies. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailNormalization of transcranial magnetic stimulation points by means of atlas registration
Zosso, D.; Noirhomme, Quentin ULg; Davare, M. et al

in Proceedings of 14th European Signal Processing Conference (2006)

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See detailContribution à l'étude de la perception des métabolites secondaires d'origine végétale et aphidienne et de leurs impacts sur l'induction de la ponte du syrphe prédateur Episyrphus balteatus (DeGeer) (Diptera, Syrphidae)
Leroy, Pascal ULg

Master's dissertation (2006)

The predator Episyrphus balteatus (DeGeer) (Diptera, Syrphidae), efficient in the biological control against the aphids is able to perceive most of the volatile compounds from plants and aphids. All these ... [more ▼]

The predator Episyrphus balteatus (DeGeer) (Diptera, Syrphidae), efficient in the biological control against the aphids is able to perceive most of the volatile compounds from plants and aphids. All these semiochemicals define the different relationships between the three trophic levels (plant-phytophagous-predator) and directly help E. balteatus, as other predators and parasitoids, to locate their prey. In this context, our study highlights the importance of plant and aphid semiochemicals in the foraging behavior of the predator E. balteatus. [less ▲]

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See detailVenus' ultraviolet airglow and aurora: Monte Carlo simulations and comparison with observations
Gérard, Jean-Claude ULg; Shematovich, V. I.; Bisikalo, D. V. et al

in European Planetary Science Congress 2006 (2006)

The Venus airglow has been observed from spectrometers on board rockets probes and satellites such as OUVS on Pioneer Venus Venera Galileo HUT on the Space Shuttle and quite recently SPICAV on Venus ... [more ▼]

The Venus airglow has been observed from spectrometers on board rockets probes and satellites such as OUVS on Pioneer Venus Venera Galileo HUT on the Space Shuttle and quite recently SPICAV on Venus Express The spectrum is dominated by emissions from helium hydrogen oxygen and carbon lines and CO bands Localized emissions of OI at 1304 and 1356 A have been sporadically observed on the nightside and are likely caused by precipitation of auroral electrons in the wake of the planet We have developed a Monte Carlo code solving the Boltzmann equation for energetic electrons to calculate the energy distribution function and fluxes of primary and secondary auroral electrons and for photoelectrons The model is used to calculate the vertical distribution of the excitation rate of various excited states For optically thick transitions such as the 3P-3S triplet at 1304 A a radiative transfert code is used to calculate the emergent emission rate We find that the relative intensity of the oxygen and CO Cameron band emissions is a sensitive indicator of the energy of auroral electrons The observed values indicate that the mean energy is on the order of 10-50 eV Dayglow intensity and distributions are also compared with observed characteristics [less ▲]

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