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See detailUV-targeted dinucleotides are not depleted in light-exposed prokaryotic genomes
Palmeira, Leonor ULg; Gueguen, Laurent; Lobry, Jean R

in Molecular Biology and Evolution (2006), 23(11), 2214--2219

We have investigated the hypothesis that pyrimidine dinucleotides are avoided in light-exposed genomes as the result of selective pressure due to high ultraviolet (UV) exposure. The main damage to DNA ... [more ▼]

We have investigated the hypothesis that pyrimidine dinucleotides are avoided in light-exposed genomes as the result of selective pressure due to high ultraviolet (UV) exposure. The main damage to DNA produced by UV radiation is known to be the formation of pyrimidine photoproducts: it is estimated that about 10 dimers per minute are formed in an Escherichia coli chromosome exposed to the UV light in direct overhead sunlight at sea level. It is also known that on an E. coli chromosome exposed to UVb wavelengths (290-320 nm), pyrimidine photoproducts are formed in the following proportions: 59 TpT, 7 CpC, and 34 CpT plus TpC. We have analyzed all available complete prokaryotic genomes and the model organism Prochlorococcus marinus and have found that pyrimidine dinucleotides are not systematically avoided. This suggests that prokaryotes must have sufficiently effective protection and repair systems for UV exposure to not affect their dinucleotide composition. [less ▲]

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See detailFrom an architectural sketch to feasible structural systems
Mora, Rodrigo; Juchmes, Roland ULg; Rivard, Hugues et al

in Gero, John, S.; Goel, Ashok K. (Eds.) Proceedings of the Second International Conference on Design Computing and Cognition (2006)

The goal of this research is to propose an integrated approach to incorporate structural engineering concerns into architectural schematic designs for timely and well-informed decision making. This is ... [more ▼]

The goal of this research is to propose an integrated approach to incorporate structural engineering concerns into architectural schematic designs for timely and well-informed decision making. This is done through a platform that is based on two software prototypes, EsQUIsE for capturing and interpreting architectural sketches, and StAr for assisting engineers during conceptual structural design. An integrated information model is provided for communication. Given the dissimilar “quality” of the information managed by both prototypes, sketch interpretation mechanisms are also required to “tune-up” communications for bringing the sketch to a precise structural engineering definition. As a result, the engineer can propose feasible structural systems earlier than usual. [less ▲]

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See detailTNFa and IKKb-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKg and NF-kB activation
Bonif, Marianne; Meuwis, Marie-Alice ULg; Close, Pierre ULg et al

in Biochemical Journal (2006), 394

Pro-inflammatory cytokines trigger signalling cascades leading to NF-kappaB (nuclear factor-kappaB)-dependent gene expression through IKK [IkappaB (inhibitory kappaB) kinase]-dependent phosphorylation and ... [more ▼]

Pro-inflammatory cytokines trigger signalling cascades leading to NF-kappaB (nuclear factor-kappaB)-dependent gene expression through IKK [IkappaB (inhibitory kappaB) kinase]-dependent phosphorylation and subsequent degradation of the IkappaB proteins and via induced phosphorylation of p65. These signalling pathways rely on sequentially activated kinases which are assembled by essential and non-enzymatic scaffold proteins into functional complexes. Here, we show that the pro-inflammatory cytokine TNFalpha (tumour necrosis factor alpha) promotes TANK [TRAF (TNF receptor-associated factor) family member associated NF-kappaB activator] recruitment to the IKK complex via a newly characterized C-terminal zinc finger. Moreover, we show that TANK is phosphorylated by IKKbeta upon TNFalpha stimulation and that this modification negatively regulates TANK binding to NEMO (NF-kappaB essential modulator). Interestingly, reduced TANK expression by RNA interference attenuates TNFalpha-mediated induction of a subset of NF-kappaB target genes through decreased p65 transactivation potential. Therefore the scaffold protein TANK is required for the cellular response to TNFalpha by connecting upstream signalling molecules to the IKKs and p65, and its subsequent IKKbeta-mediated phosphorylation may be a mechanism to terminate the TANK-dependent wave of NF-kappaB activation. [less ▲]

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See detailBiocontrol of blue mold on apple fruits by Aureobasidium pullulans (strain Ach 1-1): in vitro and in situ evidence for the possible involvement of competition for nutrients.
Bencheqroun, S Krimi; Bajji, M.; Massart, Sébastien ULg et al

in Communications in agricultural and applied biological sciences (2006), 71(3 Pt B), 1151-1157

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See detailHomenaje conmemorativo a Manuel Sacristán
Ceballos Viro, Alvaro ULg

in Revista de Hispanismo Filosófico (2006)

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See detailPartenariat F.N.P.S.M.S. - ULg / Rapport d'activité ULg 2005
Périlleux, Claire ULg; Van Kerkhoven, Fabrizio; Jennès, Nicolas

Report (2006)

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See detailEtude géologique de la carrière de Cielle (Rendeux, Dévonien inférieur)
Poty, Edouard ULg; Mottequin, Bernard ULg; Barchy, Laurent et al

Report (2006)

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See detailINTERREG III Projekt: Erdbebenmikrozonierung am südlichen Oberrhein: Teilbericht 2
Havenith, Hans-Balder ULg; Fäh, Donat

Report (2006)

Um Abschätzungen der S-Wellengeschwindigkeit für die verschiedenen geologischen Formationen in der Region zu erhalten, wurde eine grosse Anzahl von Arraymessungen durchgeführt. Das Ziel einer solchen ... [more ▼]

Um Abschätzungen der S-Wellengeschwindigkeit für die verschiedenen geologischen Formationen in der Region zu erhalten, wurde eine grosse Anzahl von Arraymessungen durchgeführt. Das Ziel einer solchen Messung ist die Bestimmung der Phasengeschwindigkeit der Rayleighwellen (Fundamentalmode und höhere Moden) als Funktion der Frequenz. Aus der Phasengeschwindigkeit lassen sich Modelle für die S-Wellengeschwindigkeit der lokalen Struktur invertieren. Bei der Inversion werden sowohl geologische Informationen, als auch die gemessene Eigenfrequenz der Lockersedimente und die Eigenschaften der gemessenen H/V Kurve verwendet. Ergänzt wurden die Messungen des Schweizerischen Erdbebendienstes durch Messungen des Bureau de Recherche Geologique et Miniere (BRGM) und des Leibniz Instituts für Geowissenschaftliche Gemeinschaftsaufgaben, Hannover (GGA). Abbildung 1 zeigt die Standorte der durchgeführten Messungen im Untersuchungsgebiet. Die Charakterisierung der verschiedenen geologischen Strukturen ist die Grundlage für die Entwicklung von Modellen für die numerische Modellierung. [less ▲]

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See detailMédias dominants et altermondialisme. De l’ouverture à la censure
Geuens, Geoffrey ULg

in Durand, Pascal; Hébert, Pierre; Mollier, Jean-Yves (Eds.) et al La censure de l’imprimé. Belgique, France, Québec et Suisse romande (XIXe et XXe siècles) - Actes du colloque international Censure et Imprimé (Université de Versailles, Saint-Quentin-en-Yvelines, 21-23 mai 2002) (2006)

Les débats médiatiques sur la mondialisation s’articulent autour de deux thèses apparemment antagonistes. Pour les partisans du libéralisme économique et les représentants des milieux d’affaires, il ... [more ▼]

Les débats médiatiques sur la mondialisation s’articulent autour de deux thèses apparemment antagonistes. Pour les partisans du libéralisme économique et les représentants des milieux d’affaires, il s’agit de condamner l’interventionnisme et le dirigisme politique dans le libre-jeu de l’économie de marché. Les chefs de file syndicaux et dirigeants réformistes de l’« altermondialisme », entendent, quant à eux, défendre, bec et ongles, l’idée d’un personnel politique victime de la bourse et des pressions de divers lobbies industriels et financiers. Dans les deux cas pourtant, on procède à une dissociation artificielle et trompeuse de l’économique et du politique. Cette représentation dominante de la mondialisation est à l’origine d’une censure, celle qui, derrière le paravent de l’Etat « victime » ou « bourreau » des marchés, refuse la parole aux critiques dénonçant les liens organiques entre pouvoirs économique, politique et médiatique. [less ▲]

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See detailLes enjeux de la citoyenneté européenne
Carlier, Jean-Yves ULg

in Leclerc, Stéphane; Akandji-Kombé, Jean-François (Eds.) La citoyenneté européenne (2006)

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See detailReducing the uncertainty of hydrogeological parameters by co-conditional simulations: lessons from practical applications in aquifers and in low permeability layers
Dassargues, Alain ULg; Rentier, Céline; Huysmans, Marijke

in Calibration and Reliability in Groundwater Modelling: From Uncertainty to Decision Making (2006)

Stochastic simulation of aquifer heterogeneity is now often performed to provide a confidence interval of the modelled results for flow and solute transport problems. In practice, due to the few available ... [more ▼]

Stochastic simulation of aquifer heterogeneity is now often performed to provide a confidence interval of the modelled results for flow and solute transport problems. In practice, due to the few available measurements of the hydraulic conductivity (hard data), it is useful to integrate several other properties of the medium as indirect data (soft data). The additional conditioning obtained from the use of these secondary data allows reduction of the variance of the distribution and consequently decrease of the uncertainty of the results. This practice can also be extended to low permeability clay layers. For example, stochastic sequential simulation can be performed involving hydraulic conductivity values as hard data, and grain size measurements, electrical resistivity log, gamma ray log and a description of the lithology variation as soft data. However, other important properties can also be considered. The possible fracturing of clay strongly influences the flow and solute transport. On the other hand, in very low permeability media, diffusion can be considered as the dominant transport mechanism, so that heterogeneity in terms of the effective diffusion coefficient becomes important. Examples of application are summarized considering aquifers and low permeability clay layers. It clearly shows the great advantage of collecting multiple data sets of inter-correlated data on the same geological medium to be modelled. In high conductivity aquifers as well as in low permeability layers, this kind of additional conditioning obtained from various data is always useful when considering applications such as, among many others, well capture zones delineation, impact studies and geological confinement of wastes. [less ▲]

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See detailCaractérisation isotopique des eaux du granite et de l’auréole métamorphique d’Oulmès (Maroc central)
Olive, Philippe; Dassargues, Alain ULg; Griere, Olivier et al

in Integrated Water Resources management and Challenges of the Sustainable Development (2006)

Dans le bassin d’Oulmès sont exploitées et commercialisées par la société des Eaux Minérales d’Oulmès qui constitue le plus gros embouteilleur d’eaux minérales du Maroc :Sidi Ali Lala Haya. Le pluton ... [more ▼]

Dans le bassin d’Oulmès sont exploitées et commercialisées par la société des Eaux Minérales d’Oulmès qui constitue le plus gros embouteilleur d’eaux minérales du Maroc :Sidi Ali Lala Haya. Le pluton granitique, d’âge hercynien, d’Oulmès est un granite à biotite et muscovite. Il présente une fracturation très marquée et un système filonien très développé. L’altération, très poussée, se manifeste par une arénitisation généralisée qui s’étend en profondeur. Le kaolin caractérise cette altération d’origine hydrothermale. L’eau de Lalla Haya émerge dans les granites à la faveur de fissures à une température de 42°C, il s’agit d’une eau carbo-gazeuse, bicarbonatée sodique. L’auréole métamorphique générée par ce granite englobe la formation des schistes en dalles, roches métapélitiques cambro-ordoviciennes homogènes. L’eau de Sidi Ali est faiblement minéralisée, elle aussi bicarbonatée sodique avec une pression partielle de CO2 non négligeable L’utilisation de l’outil isotopique a permis de préciser un certain nombre de points concernant la recharge et l’écoulement des eaux souterraines dans le bassin d’Oulmès. Les teneurs en 18O d’une vingtaine de sources situées autour du site et étagées entre 300 et 2000 m s’alignent suivant un gradient de -0,21 ‰ / 100 m. La zone de recharge commune des eaux du granite et des schistes en dalle se situe vers 1100/1300 m. De plus le rapport 18O/D pour ces deux types d’eau indique un appauvrissement en 18O de près de 1 ‰ dû à un échange avec le CO2 magmatique. Le temps de séjour moyen des eaux dans l’auréole métamorphique est de quelques dizaines d années (présence de 3H thermonucléaire) et, au moins, de plusieurs centaines d’années dans les eaux du massif granitique (absence de 3H thermonucléaire). De la remontée de CO2 magmatique, à 14C mort, il résulte que la teneur en 14C du carbone minéral dissous est quasiment nulle et qu’il vieillit, plus ou moins, les activités en 14C du carbone minéral dissous des eaux de l’auréole. En conclusion l’eau qui s’infiltre dans les fractures du massif granitique où elle se réchauffe suivant un gradient géothermique d’environ 40°C/km. Comme le géothermomètre Na/K indique une température de 165 °C, elle atteint une profondeur de l’ordre de 2 à 3 km. Elle s’est enrichie en CO2 magmatique et remonte par effet de gaz lift et donne naissance à Lalla Haya. Cette remontée ne se limite pas au seul massif granitique mais s’étend à l’auréole métamorphique en profitant des fractures du massif et des filons de quartz en provenance du batholite où elle se mélange, en proportions variables, aux eaux récentes qui se sont infiltrées directement sur les schistes en dalles. Ce sont ces fluides hydrothermaux qui ont donné naissance aux dépôts hydrothermaux autrefois exploités en mines (Sn). [less ▲]

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See detailHuman Biomonitoring of Persistent Toxicants using Comprehensive Two-Dimensional Gas Chromatography and Time-of-Flight Mass Spectrometry
Focant, Jean-François ULg; Sjodin, Andreas; Patterson, Donald G.

in Niessen, W. M. A. (Ed.) The Encyclopedia of Mass Spectrometry, Volume 8, Hyphenated Methods (2006)

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See detailLe partage de l'empirique et du transcendantal. Essai sur la normativité de la raison : Kant, Hegel, Husserl
Seba, Jean-Renaud ULg

Book published by Ousia (2006)

The present study attemps to account for the complexity of the issues tackled. It explores the nature and indeed the very foundation of reason, relating three major philosophers. The transcendantal ... [more ▼]

The present study attemps to account for the complexity of the issues tackled. It explores the nature and indeed the very foundation of reason, relating three major philosophers. The transcendantal foundation of empiricism is itself founded - ultimately - on an anthropological empirical foundation in a dialectical circle. [less ▲]

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See detailUtilisation d'un concentré riche en fibres pour la prévention des crises chez le cheval poussif
Bedoret, Denis; de Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Pratique Vétérinaire Equine (2006), 38(149), 57-64

"Heaves" is a recurrent allergic inflammatory disease initiated by inhalation of organic dust from hay and litter. Reduction in exposure to dust is the basis of prevention and treatment of attacks in ... [more ▼]

"Heaves" is a recurrent allergic inflammatory disease initiated by inhalation of organic dust from hay and litter. Reduction in exposure to dust is the basis of prevention and treatment of attacks in horses. Substitution of hay by wilted grass silage is recommended but is often not given because of the required high work load and possible risk of botulism. An alternative is the use of fibrous food without forage. Nine "heave" horses were placed in two groups at random. One group received concentrate enriched with short-strand lucerne for six weeks and the other group the reference feed consisting of silage based concentrate. After a period of recovery, the protocol was repeated and the groups reversed. Respiratory and circulatory functions, degree of fatness, feeding time and consumption of water were evaluated. No significant difference in respiratory and circulatory parameters was observed. The feeding time was significantly higher for concentrate enriched with lucerne fibers. A concentrate rich in fibers may limit attacks as does silage, which has risks associated with consumption [less ▲]

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See detailPersistent Ischemic Mitral Regurgitation After Annuloplasty can be Predicted by Pre-operative Echocardiography.
Sénéchal, M; Magne, Julien ULg; Pibarot, P et al

Conference (2006)

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See detailNormalization of transcranial magnetic stimulation points by means of atlas registration
Zosso, D.; Noirhomme, Quentin ULg; Davare, M. et al

in Proceedings of 14th European Signal Processing Conference (2006)

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See detailTen geleide
Spinoy, Erik ULg

in Freespace Nieuwzuid (2006), 6(21), 5

This is an introduction to a special issue of Nieuwzuid on the writing of literary history.

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