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See detailInfluence de la variété de blé tendre sur les caractéristiques physico-chimiques et les propriétés techno-fonctionnelles de l'amidon
Massaux, Carine; Lenartz, Jonathan; Bodson, Bernard ULg et al

Poster (2006, November 20)

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See detailAdvances in hormone replacement therapy with drospirenone, a unique progestogen with aldosterone receptor antagonism
Palacios, S.; Foidart, Jean-Michel ULg; Genazzani, A. R.

in Maturitas (2006), 55(4), 297-307

Unlike other currently available progestogens, drospirenone (DRSP) has a pharmacological profile, which closely mimics that of endogenous progesterone, most notably potent anti-aldosterone and anti ... [more ▼]

Unlike other currently available progestogens, drospirenone (DRSP) has a pharmacological profile, which closely mimics that of endogenous progesterone, most notably potent anti-aldosterone and anti-androgenic effects. Consequently, DRSP, when combined with 17 beta-estradiol (E2) as hormone replacement therapy (HRT), offsets E2-related water and sodium retention by blocking the mineralocorticoid receptor. This review evaluates the potential benefits offered by DRSP as the progestin component of HRT with respect to its anti-aldosterone activity, which translates into positive effects on body weight and blood pressure in clinical trials of continuous, combined E2/DRSP in post-menopausal women. In a 1-year, large-scale, randomised, controlled trial, E2 1 mg/DRSP 2 mg significantly decreased mean body weight by 1.2 kg versus baseline (P < 0.001), whereas patients receiving E2 1 mg gained weight. E2 1 mg/DRSP 2 mg also significantly lowered mean systolic blood pressure (SBP) by 9.0 mmHg from baseline (P < 0.05) versus 3.7 mmHg in the E2 1 mg group (P = 0.220) in a sub-group of hypertensive women. In addition, E2/DRSP was not associated with hyperkalaemia (potassium >= 5.5 meq/L) irrespective of concomitant use of ACE inhibitors, angiotensin II receptor antagonists or non-steroidal anti-inflammatory drugs, and co-morbid diabetes mellitus. In summary, as well as effectively treating climacteric symptoms, DRSP 2 mg combined with E2 I mg has shown positive effects on body weight and blood pressure in clinical trials, most likely due to DRSP's anti-aldosterone properties. This combination may therefore offer an alternative therapeutic option with additional benefits beyond current HRT agents for symptomatic post-menopausal women. (c) 2006 Elsevier Ireland Ltd. All rights reserved. [less ▲]

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See detailLes interférences analytiques dans les dosages immunologiques
Cavalier, Etienne ULg

Conference given outside the academic context (2006)

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See detailLe règlement collectif de dettes - Première réforme et nouveautés
Grella, Vanessa ULg

in Journal des Tribunaux (2006)

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See detailSacré-profane, des frontières incertaines. La cité comme théâtre religieux au XVIIe siècle
Delfosse, Annick ULg

Scientific conference (2006, November 18)

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See detailAlla Scoperta dell' Epidemiologia
Beckers, Albert ULg

Scientific conference (2006, November 18)

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See detailNew developments in benzopyran derivatives as pancreatic β-cell KATP channel openers
Florence, X.; De Tullio, Pascal ULg; Lebrun, P. et al

Poster (2006, November 18)

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See detailPharmacological evaluation of TP receptor antagonists by differential activity on alpha and beta isoforms
Hanson, Julien ULg; Dogne, J. M.; Ghiotto, J. et al

Poster (2006, November 18)

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See detailSérapis sur les gemmes et les bijoux antiques. Un portrait du dieu en images
Veymiers, Richard ULg

Scientific conference (2006, November 17)

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See detailCat is a major allergen in patients with asthma from west Siberia, Russia
Gusareva, Elena ULg; Bragina, Elena; Deeva, Evgenia et al

in Allergy (2006), 61(4), 509-510

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See detailLe Goût du mort. Mauvais goût et limites du spectateur
Tomasovic, Dick ULg

Conference (2006, November 17)

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See detailLes structures institutionnelles belges
Fournier, Bernard ULg

Scientific conference (2006, November 17)

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See detailLe financement des cultes et des organisations laïques en Belgique
Husson, Jean-François ULg

Conference (2006, November 17)

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See detailFamilial Pituitary Adenomas (Lettura Magistrale)
Beckers, Albert ULg

Scientific conference (2006, November 17)

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See detailProfessionalizing the Developers: Looking for Transfer to Faculty Practice
Poumay, Marianne ULg

Scientific conference (2006, November 17)

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