Spontaneous pneumocephalus caused by the association of pneumosinus dilatans and meningioma - Case illustration

in Journal of Neurosurgery (2006), 105(6), 934

Analyse des personnes en insertion, des employeurs et des actions menées par les jobcoachs dans le cadre du projet Flora

Report (2006)

The first orbital solution for the massive colliding-wind binary HD 93162 ( WR 25)

in Astronomy and Astrophysics (2006), 460(3), 777-782

Context. Since the discovery, with the EINSTEIN satellite, of strong X-ray emission associated with HD 93162 (equivalent to WR 25), this object has been predicted to be a colliding-wind binary system ... [more ▼]

Context. Since the discovery, with the EINSTEIN satellite, of strong X-ray emission associated with HD 93162 (equivalent to WR 25), this object has been predicted to be a colliding-wind binary system. However, radial-velocity variations that would prove the suspected binary nature have yet to be found. Aims. We spectroscopically monitored this object to investigate its possible variability to address this discordance. Methods. We compiled the largest available radial-velocity data set for this star to look for variations that might be due to binary motion. We derived radial velocities from spectroscopic data acquired mainly between 1994 and 2006, and searched these radial velocities for periodicities using different numerical methods. Results. For the first time, periodic radial-velocity variations are detected. Our analysis definitively shows that the Wolf-Rayet star WR 25 is an eccentric binary system with a probable period of about 208 days. [less ▲]

Mise en place d’un plan de prévention du stress à l’aide du WOCCQ : témoignage d’une bonne pratique

Conference given outside the academic context (2006)

Effect of timing of surgery on survival after preoperative hyperfractionated accelerated radiotherapy (HART) for locally advanced rectal cancer (LARC): Is it a matter of days?

in Acta Oncologica (2006), 45(8), 1086-1093

We intend to analyse retrospectively whether the time interval ("gap duration" = GD) between preoperative radiotherapy and surgery in locally advanced rectal cancer (LARC) has an impact on overall ... [more ▼]

We intend to analyse retrospectively whether the time interval ("gap duration" = GD) between preoperative radiotherapy and surgery in locally advanced rectal cancer (LARC) has an impact on overall survival (OS), cancer specific survival (CSS), disease free survival (DFS) and local control (LC). Two hundred seventy nine patients with LARC were entered in Trial 93-01 (hyperfractionated accelerated radiotherapy 41.6 Gy/26 Fx BID) shortly followed by surgery. From these 250 patients are fully assessable. The median GD of 5 days was used as a discriminator. The median follow-up for all patients was 39 months. GD > 5 days was a significant discriminator for actuarial 5-years OS (69% vs 47%, p = 0.002), CSS (82% vs 57%, p = 0.0007), DFS (62% vs 41%, p = 0.0003) but not for LC (93% vs 90%, p = non-significant). In multivariate analysis, the following factors independently predict outcome; for OS: age, GD, circumferential margin (CM) and nodal stage (ypN); for CSS: GD, ypN and vascular invasion (VI); for DFS: CEA, distance to anal verge, GD, ypN and VI; for LC: CM only. Gap duration predicts survival outcome but not local control. The patients submitted to surgery after a median delay of more than 5 days had a significantly better outcome. [less ▲]

Le château de Cheverny (Loir-et-Cher), analyses dendrochronologiques

Report (2006)

NeQuick: In-Depth Analysis and New Developments

in 3rd ESA Workshop on Satellite Navigation User Equipment Technologies NAVITEC '2006 (2006, December)

An empirical model called NeQuick has been selected for the modelling and correction of the ionospheric delay contribution in GALILEO single frequency receivers. The current baseline version of NeQuick ... [more ▼]

An empirical model called NeQuick has been selected for the modelling and correction of the ionospheric delay contribution in GALILEO single frequency receivers. The current baseline version of NeQuick for GALILEO is the one available in the International Telecommunication Union – Radiocommunication Sector (ITU-R) since 2001. From that time, several improvements have been proposed leading to the need of a better understanding and comparison of these different versions and an analysis of the weaknesses. Better results have been obtained by means of simpler ionosonde and profile parameters calculations, different topside formulation and new data files. The interest of a newer version of NeQuick including the above-mentioned modifications is highlighted as its error behaviour towards latitude shows a better agreement with reality. Those modifications should be coupled to a less simplistic topside formulation involving several layers with appropriate transitions such as the proposal introduced in this paper. The need of a different treatment regarding the daily effective use of the model for GALILEO single frequency algorithm compared to a physical use (that uses monthly median underlying data) is addressed. For the analysis and comparison of the different variants of the model, a software tool with a Graphical User Interface was developed. Preliminary comparisons for the physical use between different versions and also between modelled and measured data are presented. Such comparisons should be extended in the future for the effective use of the model. Finally, the structure and analysis of the mentioned issues and the results of the different comparisons are shown. Also solutions or potential paths to investigate solutions are proposed. [less ▲]

Mapping of the bovine growth hormone secretagogue receptor (GHS-R) and polymorphism study in cattle

Poster (2006, December)

A third control pathway of the Growth Hormone (GH) secretion has come into picture since the development of synthetic compounds known as Growth Hormone Secretagogues (GHSs). The GHS Receptor (GHS-R) and ... [more ▼]

A third control pathway of the Growth Hormone (GH) secretion has come into picture since the development of synthetic compounds known as Growth Hormone Secretagogues (GHSs). The GHS Receptor (GHS-R) and its subtype are abundantly located in the hypothalamus-pituitary unit, but are also distributed in other central areas and peripheral tissues. The GHS-R belongs to the G-protein coupled receptor family with seven transmembrane domain architecture. In order to determine the GHS-R gene sequence, total mRNA was extracted from abomasum and two types of GHS-R cDNA were identified. These two types are transcript variants (1a and 1b) of the same GHS-R gene. The gene encompasses two exons and a single intron. Using a 3000 Rad hybrid panel, the GHS-R gene was mapped to Bos taurus autosome 1 (BTA 1). This localization on BTA 1 agrees totally with comparative data between cattle and human since BTA 1 corresponds to part of human chromosome 3 where human GHSR is also mapped. By two-point analysis, most significantly linked marker are BL26 and BMS4031 (both LOD score : 5,66). Some studies detected different QTLs near these markers like for growth rate, carcass yield, milk portein and milk yield. In the cattle industry, it is of economical importance to increase plasma GH secretion because it is associated with faster growth, less fat stores and improved milk production. Being of economical importance and the detected QTLs near the GHS-R gene, it would be interesting to study the polymorphism on the bovine GHS-R gene. Screening for polymorphisms in the two exons on ten Belgian Blue bulls, ten Holsteins bulls and ten Limousin bulls revealed a total of four single nucleotide polymorphisms (SNPs): three SNPs are in the first exon and one SNP in the second exon. In order to evaluate if GHS-R could be involved in genetic variation for growth rate, carcass yield, milk portein and milk yield, an association study between SNPs on GHS-R gene and these traits could be performed in a major cattle population. [less ▲]

Chronic low back pain. Good clinical practice (GCP)

Report (2006)

Synthesis and radioligand binding studies of methoxylated 1,2,3,4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2+- activated K+ channels

in Journal of Medicinal Chemistry (2006), 49(24), 7208-7214

Several methoxylated 1,2,3,4-tetrahydroisoquinoliniums derived from N-methyl-laudanosine and N-methyl-noscapine were synthesized and evaluated for their affinity for apamin-sensitive binding sites. The ... [more ▼]

Several methoxylated 1,2,3,4-tetrahydroisoquinoliniums derived from N-methyl-laudanosine and N-methyl-noscapine were synthesized and evaluated for their affinity for apamin-sensitive binding sites. The quaternary ammonium derivatives have a higher affinity with regard to the tertiary amines. 6,7-Dimethoxy analogues possess a higher affinity than the 6,8- and 7,8- dimethoxy isomers. A 3,4-dimethoxybenzyl or a 2-naphthylmethyl moiety in C-1 position are more favorable than a 3,4-dimethoxyphenethyl group. Smaller groups such as propyl or isobutyl are unfavorable. In 6,7-dimethoxy analogues, increasing the size and lipophilicity with a naphthyl group in the C-1 position leads to a slight increase of affinity, while the same group in the 6,7,8- trimethoxy series is less favorable. The 6,7,8- trimethoxy derivative 3f is the first tertiary amine in the series to possess an affinity close to that of N-methyl-laudanosine and N-methyl-noscapine. Moreover, electrophysiological studies show that the most effective compound 4f blocks the apamin-sensitive afterhyperpolarization in rat dopaminergic neurons. [less ▲]