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See detailLe cas clinique du mois. Syndrome malin des neuroleptiques et paralysie generale
Foatelli, F. M.; gernay, p; Lievens, Isabelle ULg et al

in Revue Médicale de Liège (2006), 61(12), 807-11

Described in 1960 by Jean Delay in relation to the use of haloperidol, neuroleptic malignant syndrome remains relatively rare, and poorly known by the medical profession. The emergence of the atypical ... [more ▼]

Described in 1960 by Jean Delay in relation to the use of haloperidol, neuroleptic malignant syndrome remains relatively rare, and poorly known by the medical profession. The emergence of the atypical antipsychotic agents and preventive measures which have become general in recent years in hospital departments using dopamine receptor antagonists has not altered the prognosis, which remains potentially fatal in approximately a quarter of cases. This article proposes a descriptive summary of this syndrome in terms of clinical and biological diagnostics as well as of evolution, epidemiology, differential diagnosis and treatment. It describes the case of a patient affected by general paralysis having developed a neuroleptic malignant syndrome, thus the hypothesis what the neuroleptic malignant syndrome preferentially arises in subjects having underlying organic or metabolic problems and provides food for thought regarding the main medical and psychiatric overlaps, the use of dopaminergic agents and the behaviour to be adopted when dealing with a patient presenting with inaugural psychiatric symptomatology. [less ▲]

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See detailPromotion de la santé à l'école ... Les modifications tant attendues de deux décrets
Vandoorne, Chantal ULg

in Education Santé (2006), (218), 7-8

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See detailA contribution to the audit of an air-conditioning system: modeling, simulation and benchmarking
Adam, Christophe; Andre, Philippe ULg; Hannay, Cleide et al

(2006, December)

This paper intends to show how benchmarks can help in the audit of a HVAC system and how these benchmarks can be generated. The work presented is part of the European “AUDITAC” project. How can an auditor ... [more ▼]

This paper intends to show how benchmarks can help in the audit of a HVAC system and how these benchmarks can be generated. The work presented is part of the European “AUDITAC” project. How can an auditor declare that a given HVAC is “consuming too much”? He can’t make any judgment, if not having some reference, i.e. some “benchmarks” available. Focus is given here to cooling regime, but even then, heating cannot be forgotten (for example, the remaining heating demand can be satisfied thanks some recovery on the condensers of the chillers). The dramatic question is: what should be the consumption(s) for such a building, in such a climate, with such occupancy, such internal loads and such actual indoor environment? Better than to look for a (very hypothetical) global weather index, similar to heating degree-days, it seems more rational to run a simulation model on a few thousands of hours, corresponding to one (or to several) cooling season(s). Current performances of simulation tools make this approach very expedient. The climate can then be considered as it is, without any simplification. The main simplification is still welcome on the system (building + HVAC) side, in order to get calculation robustness, easy understanding and easy parameter identification. In this perspective, the building has to be subdivided in a very limited number of zones and only a few components of the HVAC system have to be included in the simulation model, with as simple as possible control strategies. [less ▲]

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See detail18f-Fdg Pet Imaging in Assessing Exudative Pleural Effusions
DUYSINX, Bernard ULg; Larock, Marie-Paule ULg; Nguyen, Delphine et al

in Nuclear Medicine Communications (2006), 27(12), 971-6

BACKGROUND: This study evaluates the accuracy of [F]fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging with semi-quantitative analysis for differentiating benign from malignant pleural ... [more ▼]

BACKGROUND: This study evaluates the accuracy of [F]fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging with semi-quantitative analysis for differentiating benign from malignant pleural exudates and for guiding the search for the primary tumour of pleural metastases. METHODS: Whole-body 18F-FDG PET was performed in 79 patients with exudative pleurisy. Standard uptake values were normalized for body weight, body surface area, lean body mass (SUVbw, SUVbsa, SUVlbm) with and without correction for blood glucose levels. Thoracoscopy was systematically performed to reveal pathological diagnosis. RESULTS: All SUVs were significantly higher in all malignant pleural diseases (n = 51) than in benign (n = 28) (P < 0.001). Moreover SUVs were greater in the pleural metastases from pulmonary primaries (n = 25) and in mesotheliomas (n = 8) than in extrathoracic primaries (n = 18) (P < 0.01) with no significant difference between lung cancers and mesotheliomas. Receiver operating curve (ROC) analysis between benign and malignant lesions showed areas under the curves that ranged from 0.803 (SUVbsa g) to 0.863 (SUVbw). The cut-off value for SUVbw which gave the best accuracy (82.3%) was 2.2. When comparing thoracic with extrathoracic primaries the highest accuracy (80.4%) was found for a cut-off value of 2.6. CONCLUSION: Semi-quantitative analysis of 18F-FDG PET imaging helps to differentiate malignant from benign pleural exudates and to distinguish between thoracic or extrathoracic primaries. [less ▲]

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See detailFrom model validation to production of reference simulations: how to increase reliability and applicability of building and HVAC simulation models
Adam, Christophe; Andre, Philippe ULg; Georges, Bernard ULg et al

(2006, December)

Validation of simulation models appears from a long time as a key issue in order to promote a more intensive and more efficient use of simulation models in the field of building and HVAC simulation. IEA ... [more ▼]

Validation of simulation models appears from a long time as a key issue in order to promote a more intensive and more efficient use of simulation models in the field of building and HVAC simulation. IEA Annex 34/43 originally targeted a number of specific applications where a more advanced validation was required: ground coupling problems, multizone building, shading, day lighting and cooling load interaction, HVAC components and ventilated facades. These validation exercises were built on the large methodological experience obtained in previous projects and address sometimes very fundamental problems of heat transfer in buildings. Consulting engineers and practitioners might see these exercises as a bit too far from their objectives and it is the reason why an additional activity was proposed with the specific aim of producing, based upon the results of the validation of models, a set of reference simulations. These applications cover a range of building types (residential, commercial) and systems (production, distribution emission) and run in a variety of climates. The paper will describe how models dedicated to these applications were developed, starting from validation results, going through the selection and consolidation of simulation hypothesises and ending with a number that might be considered as reference for the concerned applications. The paper will concentrate on models required by a residential building application (multizone building equipped with a heat pump or a condensing boiler). Simulations make use of both EES and TRNSYS software and both software are applied in parallel as far as possible in the different applications in order to get a better judgment of their potential advantages and drawbacks. The use of reference simulations in view of qualifying normative methods currently in development in the frame of the European Energy Performance in Buildings Directive is also addressed and demonstrated in the paper. [less ▲]

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See detailAdvances in immunoproteomics for serological characterization of microbial antigens
Falisse-Poirier, Nandini; Ruelle, Virginie ULg; Elmoualij, Benaïssa ULg et al

in Journal of Microbiological Methods (2006), 67(3), 593-596

We propose a multi-dimensional strategy, associating immunodetection to a protein fractionating two-dimensional liquid chromatography tool, for serological characterization of microbial antigens. The ... [more ▼]

We propose a multi-dimensional strategy, associating immunodetection to a protein fractionating two-dimensional liquid chromatography tool, for serological characterization of microbial antigens. The originality of such immunoproteomic approaches resides in their application in large-scale studies for rapid serotyping of micro-organisms, evaluation of immunomes and could be proposed in the development and monitoring of vaccines. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailModeling and simulation of an air conditioning chilled water system
Lebrun, Jean ULg; Lemort, Vincent ULg; Teodorese, Ion

(2006, December)

This paper is giving an overview of problems encountered and solutions available for the simulation of an air conditioning system. Focus is given on the chilling water subsystem (from the chiller to the ... [more ▼]

This paper is giving an overview of problems encountered and solutions available for the simulation of an air conditioning system. Focus is given on the chilling water subsystem (from the chiller to the cooling coil). Main component simulation models (chillers, pumps, piping, valves, cooling coils and fans) are presented; they are tuned on manufacturer’s catalogue data. The way of integrating these models into a global HVAC system simulation is illustrated thanks to one example: the simulation of (a part of) a real chilled water loop, which is submitted to an exhaustive monitoring. Cooling demands and corresponding energy consumptions are systematically simulated and measured on one-minute time basis. This provides the opportunity for a global checking of the simulation by comparing simulated and measured cooling coil outputs. Further work should also include comparisons on chiller consumptions. [less ▲]

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See detailCost estimates of brain disorders in Belgium
Schoenen, Jean ULg; Gianni, F.; Schretlen, L. et al

in Acta Neurologica Belgica (2006), 106(4), 208-214

This article presents the data on cost of the major brain disorders in Belgium which were retrieved from "Cost of Disorders of the Brain in Europe" study sponsored by the European Brain Council and ... [more ▼]

This article presents the data on cost of the major brain disorders in Belgium which were retrieved from "Cost of Disorders of the Brain in Europe" study sponsored by the European Brain Council and performed by Stockholm Health Economics. The disorders selected were : addiction, depression, anxiety disorders, brain tumours, dementia, epilepsy, migraine and other headaches, multiple sclerosis, Parkinson's disease, psychotic disorders, stroke and trauma. Figures for prevalence of disorders and direct medical, direct non-medical and indirect costs are based on data coming from available electronic data bases, or when missing for Belgium, best possible estimates or extrapolated data were used. All economic data were transformed to E's for 2004 and adjusted for purchasing power parity (PPP). The results show that the total number of people with any brain disorder in Belgium amounts to 2,9 million in 2004, the most prevalent being anxiety disorders 1.1 million, migraine 860 000, addiction (any) 800.000 and depression 500.000 cases. The total cost of all included brain disorders in Belgium was estimated at 10.6 billion Euros. Most costly per case are brain tumours, multiple sclerosis, stroke and dementia. Because of their higher prevalence, however, depression, dementia, addiction, anxiety disorders and migraine have the highest total costs. Taken together, brain disorders consume 4% of the gross national product and cost each citizen of Belgium E 1029 per year The drug costs for brain disorders constitute only 10% of the total drug market in Belgium, and only 4% of the total cost of brain disorders in Belgium. This should be compared to the cost estimates and to a previous study which showed that brain disorders are responsible for 35% of the total burden of all disorders in Europe. This study suggests therefore that the direct healthcare resources, including expenses for drug therapies, allocated to brain disorders in Belgium are not leveled to the indirect costs and burden of these disorders. A comparison with data available from a direct prospective study in demented Belgian patients suggests that the mathematical estimates presented here reflect quite accurately the real average cost for dementia, although there are large variations depending on disease severity. As, in addition, subjects with brain disorders face collateral costs which have not been taken into account and may vary between countries, it seems worthwhile to conduct, in cooperation with patients associations, a complementary survey in the Belgian ecosystem to establish the cost profile of representative patients for the major brain disorders. Such a survey is being organized by a task force of the Belgian Brain Council. [less ▲]

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See detailHigh prevalence of pituitary adenomas: A cross-sectional study in the province of Liege, Belgium
Daly, Adrian ULg; Rixhon, M.; Adam, Christelle et al

in Journal of Clinical Endocrinology and Metabolism (2006), 91(12), 4769-4775

Context: Prevalence data are important for assessing the burden of disease on the health care system; data on pituitary adenoma prevalence are very scarce. Objective: The objective of the study was to ... [more ▼]

Context: Prevalence data are important for assessing the burden of disease on the health care system; data on pituitary adenoma prevalence are very scarce. Objective: The objective of the study was to measure the prevalence of clinically relevant pituitary adenomas in a well-defined population. Design: This was a cross-sectional, intensive, case-finding study performed in three regions of the province of Liège, Belgium, to measure pituitary adenoma prevalence as of September 30, 2005. Setting: The study was conducted in specialist and general medical practitioner patient populations, referral hospitals, and investigational centers. Methods: Three demographically and geographically distinct districts of the province of Liège were delineated precisely using postal codes. Medical practitioners in these districts were recruited, and patients with pituitary adenomas under their care were identified. Diagnoses were confirmed after retrieval of clinical, hormonal, radiological, and pathological data; full demographic and therapeutic follow-up data were collected in all cases. Results: Sixty-eight patients with clinically relevant pituitary adenomas were identified in a population of 71,972 individuals; the mean (± SD) prevalence was 94 ± 19.3 cases per 100,000 population (95% confidence interval, 72.2 to 115.8). The group was 67.6% female and had a mean age at diagnosis of 40.3 yr; 42.6% had macroadenomas and 55.9% underwent surgery. Prolactinomas comprised 66% of the group, with the rest having nonsecreting tumors (14.7%), somatotropinomas (13.2%), or Cushing’s disease (5.9%); 20.6% had hypopituitarism. Conclusion: The prevalence of pituitary adenomas in the study population (one case in 1064 individuals) was more than 3.5–5 times that previously reported. This increased prevalence may have important implications when prioritizing funding for research and treatment of pituitary adenomas. [less ▲]

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See detailInżyneria powierzchni betonu. Część 2. Wpływ obrobki na powstawanie rys
Courard, Luc ULg; Garbacz, Andrzej; Nieweglowska, Anna et al

in Materialy Budowlane (2006), 12

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See detailAbrege des debuts de la chirurgie cardiaque. Conference prononcee le 6 mai 2006, a l'occasion du 30 eme anniversaire de la chirurgie cardiaque a Liege
Limet, Raymond ULg

in Revue Médicale de Liège (2006), 61(12), 812-9

Beginnings of cardiac surgery were primarily pericardiac surgery: persisting ductus ligation (Gross), coarctation repair (Crafoord) and Blalock's seminal operation of arterio-pulmonary shunt. The first ... [more ▼]

Beginnings of cardiac surgery were primarily pericardiac surgery: persisting ductus ligation (Gross), coarctation repair (Crafoord) and Blalock's seminal operation of arterio-pulmonary shunt. The first really open cardiac procedure is due to Gibbon who worked up an apparatus capable to assume heart and lungs function. In the same time, Lillehei operated on congenital cardiac lesions in children with the concept of "cross-circulation". For a long time confined in Minneapolis and Rochester, cardiac surgery spread all over USA. Starr lead the valvular surgery with the use of caged ball prosthesis (Starr-Edwards); Effler and Favaloro developed coronary surgery; outside USA, the Russian Kolessov used for the first time an internal mammary artery. As far as cardiac transplantation is concerned, a debt is due to Hardy, but the merit of the-first successful cardiac transplantation goes to South-African Barnard. [less ▲]

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See detailEntre méfiance et intégration. Les germanophones dans l'armée belge (1920-1955)
Brüll, Christoph ULg

in Cahiers Belges d'Histoire Militaire (2006), 4

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See detailResults towards identifiability properties of biochemical reaction networks
Farina, Marcello; Findeisen, Rolf; Bullinger, Eric ULg et al

in Proc. of the 45th IEEE Conference on Decision and Control, San Diego, USA (2006, December)

In this paper we consider the question of parameter identifiability for biochemical reaction networks, as typically encountered in systems biology. Specifically, we are interested in deriving conditions ... [more ▼]

In this paper we consider the question of parameter identifiability for biochemical reaction networks, as typically encountered in systems biology. Specifically, we are interested in deriving conditions on the biochemical reaction network and on the measured outputs that guarantee identifiability of the parameters. Taking the specific system structure of biochemical reaction networks into account, we derive sufficient conditions for local parameter identifiability based on a suitable system expansion which does not any more directly depend on the parameters. Rather, as shown, the problem of identifiability can be recast as the question of observability of the (parameter free) expanded system. The conditions derived are exemplified considering a simple example [less ▲]

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See detailRapport 2 projet FIRST DEI IMOBIOSE
Goffin, Dorothée ULg

Report (2006)

Le projet FIRST DEI IMOBIOSE est financé par la région wallonne et en partenariat avec la société Meurens Natural. Ce projet a pour but de produire des sirops d’isomaltooligosaccharides prébiotiques à ... [more ▼]

Le projet FIRST DEI IMOBIOSE est financé par la région wallonne et en partenariat avec la société Meurens Natural. Ce projet a pour but de produire des sirops d’isomaltooligosaccharides prébiotiques à partir de sirops de céréales et ce dans le respect du cahier des charges biologique, mais également de les caractériser d’un point de vue de leur composition et de leurs effets sur la santé. [less ▲]

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See detailApplication of MRI for improved local control in complex radiotherapy of cervical cancer
Janaki, Hadjiev; Zsolt, Cselik; Péter Bogner et al

in Archive of Oncology (2006), 14(3-4), 95-100

Background: The aim of this study was to analyze the use of magnetic resonance imaging (MRI) as a modern medical imaging technique in radiotherapy with special emphasis on the integration of MRI and a ... [more ▼]

Background: The aim of this study was to analyze the use of magnetic resonance imaging (MRI) as a modern medical imaging technique in radiotherapy with special emphasis on the integration of MRI and a novel technique in brachytherapy to optimize treatment outcome in cervical cancer. Methods: In addition to the CT based shrinking volume conformal teletherapy in 31 patients with locally advanced cervical cancer, MRI examination with a special adjustable applicator at the treatment site was performed for the brachytherapy planning. To avoid excessive doses to the healthy structures during complex cervical radiotherapy isodose curves were calculated upon the information of the MR image and dose distribution was evaluated. Results: The consecutive application of CT and MRI limited the possibility for overdosage of the critical organs and undertreatment of the advanced tumor spread in all cases. The overall response rate for the complex treatment was 74.2% with complete regression in 25.8% of the cases. Based on the exact information of the three dimensional digital data radiation doses could be optimized without increasing the possibility of acute complications rate. Conclusion: The introduction of 3D treatment planning for teletherapy pelvic and boost irradiation of cervical carcinoma as well as for the brachytherapy part of the complex treatment is to be recommended. [less ▲]

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See detailA numerical comparison of control strategies applied to an existing ice storage system
Lemort, Vincent ULg

in Energy Conversion and Management (2006), 47(20), 3619-3631

While ice storage systems are designed according to a defined strategy for warm day loads, it is interesting to consider other conventional control strategies for mid-season day loads. Three different ... [more ▼]

While ice storage systems are designed according to a defined strategy for warm day loads, it is interesting to consider other conventional control strategies for mid-season day loads. Three different charging-discharging control strategies are applied to an existing cooling plant and compared in terms of operating costs and energy consumption. A cooling plant model is built. A time stage equal to 15 min is considered to simulate numerically a whole charging-discharging process and compare the different control strategies. These simulations take into account existing technical constraints and set points. EES software is used. The operating costs of the cooling plant are evaluated by taking into account both the energy and the demand cost rate. It is shown that an ice storage system can allow savings of operating costs. However, they can increase energy consumption. (c) 2006 Elsevier Ltd. All rights reserved. [less ▲]

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See detailMolecular cloning and functional expression of a new aphid isoprenyl diphosphate synthase
Vandermoten, Sophie ULg; Beliveau, C.; Sen, S. et al

in Archives Internationales de Physiologie et de Biochimie (2006, December), 190

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See detailAutobiographical memory in non-amnesic alcohol-dependent patients
D'Argembeau, Arnaud ULg; Van der Linden, Martial ULg; Verbanck, Paul et al

in Psychological Medicine (2006), 36(12), 1707-1715

Background. Chronic alcohol abuse is associated with a wide range of cognitive deficits. However, little is known about memory for real-life events (autobiographical memory) in non-amnesic alcoholic ... [more ▼]

Background. Chronic alcohol abuse is associated with a wide range of cognitive deficits. However, little is known about memory for real-life events (autobiographical memory) in non-amnesic alcoholic patients. The purpose of this study was to investigate (a) non-amnesic alcoholics' ability to recall specific autobiographical memories and (b) their subjective experience when they access specific memories.Method. Twenty non-amnesic (without Korsakoff syndrome) recently detoxified alcoholics and 20 healthy controls completed the Autobiographical Memory Test (AMT), which assesses the frequency of specific (versus general) memories recalled in response to cue words, and the Memory Characteristics Questionnaire (MCQ), which assesses subjective experience (e.g. the amount of sensory and contextual details experienced) when remembering specific events.Results. Alcoholic patients recalled specific memories less frequently and general memories more frequently than healthy controls. Nevertheless, when a specific past event was accessed, alcoholic patients subjectively experienced as many sensory and contextual details as controls.Conclusions. These findings suggest that non-amnesic alcoholics have difficulties strategically accessing event-specific autobiographical knowledge, which might result from changes in frontal lobe function that are associated with alcoholism. [less ▲]

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See detailEnCOrE : Encyclopédie de Chimie Organique Electronique
Colaux, Catherine ULg; krief, Alain

Poster (2006, December)

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