References of "2006"
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See detailLa radiothérapie du cancer du sein
Meyns, Mia ULg

in AIDS Patient Care (2006), 4

Le traitement du cancer du sein est un des exemples les plus probants de l'approche multidisciplinaire oncologique. Dans ce contexte, la radiothérapie a renforcé sa place et son importance, même si ... [more ▼]

Le traitement du cancer du sein est un des exemples les plus probants de l'approche multidisciplinaire oncologique. Dans ce contexte, la radiothérapie a renforcé sa place et son importance, même si certaines incertitudes persistent, comme la prise en charge du creux axillaire, de la chaîne mammaire interne et de la paroi thoracique. La tendance constatée depuis plusieurs années est celle d'une approche moins agressive. [less ▲]

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See detailPreface: A tribute to Muriel Fairon-Demaret
Gerrienne, Philippe ULg

in Review of Palaeobotany and Palynology (2006), 142(3-4), 61-61

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See detail18f-Fdg Pet Imaging in Assessing Exudative Pleural Effusions
DUYSINX, Bernard ULg; Larock, Marie-Paule ULg; Nguyen, Delphine et al

in Nuclear Medicine Communications (2006), 27(12), 971-6

BACKGROUND: This study evaluates the accuracy of [F]fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging with semi-quantitative analysis for differentiating benign from malignant pleural ... [more ▼]

BACKGROUND: This study evaluates the accuracy of [F]fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging with semi-quantitative analysis for differentiating benign from malignant pleural exudates and for guiding the search for the primary tumour of pleural metastases. METHODS: Whole-body 18F-FDG PET was performed in 79 patients with exudative pleurisy. Standard uptake values were normalized for body weight, body surface area, lean body mass (SUVbw, SUVbsa, SUVlbm) with and without correction for blood glucose levels. Thoracoscopy was systematically performed to reveal pathological diagnosis. RESULTS: All SUVs were significantly higher in all malignant pleural diseases (n = 51) than in benign (n = 28) (P < 0.001). Moreover SUVs were greater in the pleural metastases from pulmonary primaries (n = 25) and in mesotheliomas (n = 8) than in extrathoracic primaries (n = 18) (P < 0.01) with no significant difference between lung cancers and mesotheliomas. Receiver operating curve (ROC) analysis between benign and malignant lesions showed areas under the curves that ranged from 0.803 (SUVbsa g) to 0.863 (SUVbw). The cut-off value for SUVbw which gave the best accuracy (82.3%) was 2.2. When comparing thoracic with extrathoracic primaries the highest accuracy (80.4%) was found for a cut-off value of 2.6. CONCLUSION: Semi-quantitative analysis of 18F-FDG PET imaging helps to differentiate malignant from benign pleural exudates and to distinguish between thoracic or extrathoracic primaries. [less ▲]

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See detailThe in vitro influences of neurotensin on the motility characteristics of human U373 glioblastoma cells
Servotte, S.; Camby, I.; Debeir, O. et al

in Neuropathology & Applied Neurobiology (2006), 32(6), 575-584

Astrocytic tumours are associated with dismal prognoses due to their pronounced ability to diffusely invade the brain parenchyma. Various neuropeptides, including gastrin, are able to modulate tumour ... [more ▼]

Astrocytic tumours are associated with dismal prognoses due to their pronounced ability to diffusely invade the brain parenchyma. Various neuropeptides, including gastrin, are able to modulate tumour astrocyte migration. While neurotensin has been shown to influence the proliferation of glioma cells and the migratory ability of a large set of other cell types, its role in glioma cell migration has never been investigated. Neurotensin-induced modifications to the motility features of human U373 glioblastoma cells therefore constitute the topic of the present study. We evidenced that three subtypes of neurotensin receptors (NTR1, NTR2 and NTR3) are expressed in U373 glioblastoma cells, at least as far as their mRNAs are concerned. Treating U373 tumour cells with 10 nM neurotensin markedly modified the morphological patterns of these cells and also profoundly altered the organization of their actin cytoskeletons. Pull-down assays revealed that neurotensin induced the activation in U373 cells of both Rac1 and Cdc42 but not RhoA. Scratch wound assays evidenced that neurotensin (0.1 and 10 nM) very significantly inhibited wound colonization by U373 cells cultured in the absence of serum. In addition, quantitative phase-contrast videomicroscopy analyses showed that neurotensin decreases the motility levels of U373 glioblastoma cells when these cells are cultured on plastic. In sharp contrast, neurotensin stimulates the motility of U373 cells when they are cultured on laminin, which is a pro-adhesive extracellular matrix component ubiquitously secreted by glioma cells. Our data thus strongly suggest that, in addition to gastrin, neurotensin is a neuropeptide capable of modulating tumour astrocyte migration into the brain parenchyma. [less ▲]

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See detailModélisation de la qualité de l’eau de surface de bassins hydrographiques pour la mise en œuvre de la Directive-cadre dans les Pays de l’Est
Everbecq, Etienne ULg; Bourouag, Mohamed ULg; Grard, Aline ULg et al

Report (2006)

Le modèle Pegase (Planification Et Gestion de l’ASsainissement des Eaux) est un modèle intégré bassins hydrographiques/rivières qui permet de calculer de façon déterministe et prévisionnelle la qualité ... [more ▼]

Le modèle Pegase (Planification Et Gestion de l’ASsainissement des Eaux) est un modèle intégré bassins hydrographiques/rivières qui permet de calculer de façon déterministe et prévisionnelle la qualité des eaux des rivières en fonction des rejets et apports de pollution (relation pression-impact). Développé depuis la fin des années 1980 à l’université de Liège, il permet d'orienter les choix des opérateurs publics et privés en matière de gestion des eaux de surface à l'échelle des petits et grands bassins versants. et privés en matière de gestion des eaux de surface à l'échelle des petits et grands bassins versants. Plusieurs pays de l’Est souhaitant obtenir un support pour les aspects techniques relatifs à la mise en œuvre de la Directive-cadre Eau 2000/60 (DCE), une application pilote du modèle PEGASE a été réalisée en Pologne sur le bassin de la Haute-Vistule, en collaboration avec deux agences de l’eau (« RZGW ») Polonaises. Cette application pilote avait été proposée par l’Office international de l’eau (OIEAU) dans le cadre du jumelage France-Pologne pour la mise en œuvre de la DCE Les tâches à effectuer reprenaient l’aide à la mise en œuvre du modèle ainsi que la formation du personnel chargé d’utiliser in fine le modèle. Le Ministère de l’Environnement polonais a considéré cette application comme étant entièrement réussie et couronnée de succès, malgré les difficultés rencontrées pour rassembler les données de base. Cette application du modèle Pegase en Pologne peut servir d’exemple et de référence pour des applications dans d’autres pays de l’Est (Roumanie, Slovénie, Bulgarie, etc). [less ▲]

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See detailSound field modeling in architectural acoustics using a diffusion equation
Picaut, Judicaël; Valeau, Vincent; Billon, Alexis ULg et al

Conference (2006, December)

A numerical approach is proposed to model the reverberated sound field in rooms. The model is based on the numerical implementation of a diffusion model enabling spatial variations of the sound energy ... [more ▼]

A numerical approach is proposed to model the reverberated sound field in rooms. The model is based on the numerical implementation of a diffusion model enabling spatial variations of the sound energy within a room, unlike the statistical theory. The proposed method allows to take into account most of complex phenomena encountered in room acoustics, like mixed reflections on walls (diffuse and specular), low and high absorption on walls, atmospheric attenuation, fitted zones. Moreover, the model can be applied to complex geometries, like multiple coupled rooms of different sizes. In this paper, the model and its numerical implementation are first detailed. Then, an application is proposed for a complex geometry defined by multiple coupled rooms with fitting objects, including low and high absorption on walls, in terms of sound level and reverberation times. The main interest of the model is that such approach requires less computational time in comparison with common approaches like ray-tracing simulations. [less ▲]

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See detailTiming and efficacy of transmitter release at mossy fiber synapses in the hippocampal network
Bischofberger, J; Engel, Dominique ULg; Frotscher, M et al

in Pflügers Archiv : European Journal of Physiology (2006), 453(3), 361-72

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See detailSurgical treatment of thoraco-abdominal and low thoracic aneurysms of the aorta. One single center experience over ten years
El Arid, J.-M.; CREEMERS, Etienne ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (2006), 106(6), 669-674

This work presents the results of surgery in thoraco-abdominal aortic aneurysms (TAA) and thoracic descending aortic aneurysms (TDA) in one single center between January 1rst, 1996 and December 31, 2005 ... [more ▼]

This work presents the results of surgery in thoraco-abdominal aortic aneurysms (TAA) and thoracic descending aortic aneurysms (TDA) in one single center between January 1rst, 1996 and December 31, 2005. It concerns open surgery in 42 and endovascular procedures in ten patients. Forty two patients (11 TDA and 31 TAA (4 type I, 12 type II, 6 type III and 9 type IV)) define the open surgery series. Twenty six patients were operated on elective basis and 16 patients in emergency condition. Surgical correction was made under partial cardio-pulmonary bypass (PCPB) in 70% of cases via femoral vessels; most significant intercostal arteries were reimplanted and cerebro-spinal fluid (CSF) drainage used in half of the cases. Operative mortality was zero in the elective group (0/26) and attained 19% in the emergent group (3/16). Mortality was linked to cerebrovascular accidents (CVA) in two cases and post-pump left lung hemorrhagic intarction in one case. The paraplegia accounts 2/26 in the elective group and one in the emergent group (1/16). That is 7.1% in both groups. At the end of five years, survival is 66% in elective group and 74% in the emergency group. Ten patients (5 TDA and 5 TAA (2 type I, 3 type III)) were treated endovascularly. Operative mortality and postoperative paraplegia were nil. [less ▲]

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See detailLe portrait dans Daguerréotypes d'Agnès Varda
Van Cauwenberge, Geneviève ULg

Conference (2006, December)

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See detailQuestions de didactique du français langue seconde (cycle de conf.)
Defays, Jean-Marc ULg

Scientific conference (2006, December)

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See detailHigh prevalence of pituitary adenomas: A cross-sectional study in the province of Liege, Belgium
Daly, Adrian ULg; Rixhon, M.; Adam, Christelle et al

in Journal of Clinical Endocrinology and Metabolism (2006), 91(12), 4769-4775

Context: Prevalence data are important for assessing the burden of disease on the health care system; data on pituitary adenoma prevalence are very scarce. Objective: The objective of the study was to ... [more ▼]

Context: Prevalence data are important for assessing the burden of disease on the health care system; data on pituitary adenoma prevalence are very scarce. Objective: The objective of the study was to measure the prevalence of clinically relevant pituitary adenomas in a well-defined population. Design: This was a cross-sectional, intensive, case-finding study performed in three regions of the province of Liège, Belgium, to measure pituitary adenoma prevalence as of September 30, 2005. Setting: The study was conducted in specialist and general medical practitioner patient populations, referral hospitals, and investigational centers. Methods: Three demographically and geographically distinct districts of the province of Liège were delineated precisely using postal codes. Medical practitioners in these districts were recruited, and patients with pituitary adenomas under their care were identified. Diagnoses were confirmed after retrieval of clinical, hormonal, radiological, and pathological data; full demographic and therapeutic follow-up data were collected in all cases. Results: Sixty-eight patients with clinically relevant pituitary adenomas were identified in a population of 71,972 individuals; the mean (± SD) prevalence was 94 ± 19.3 cases per 100,000 population (95% confidence interval, 72.2 to 115.8). The group was 67.6% female and had a mean age at diagnosis of 40.3 yr; 42.6% had macroadenomas and 55.9% underwent surgery. Prolactinomas comprised 66% of the group, with the rest having nonsecreting tumors (14.7%), somatotropinomas (13.2%), or Cushing’s disease (5.9%); 20.6% had hypopituitarism. Conclusion: The prevalence of pituitary adenomas in the study population (one case in 1064 individuals) was more than 3.5–5 times that previously reported. This increased prevalence may have important implications when prioritizing funding for research and treatment of pituitary adenomas. [less ▲]

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See detailResults towards identifiability properties of biochemical reaction networks
Farina, Marcello; Findeisen, Rolf; Bullinger, Eric ULg et al

in Proc. of the 45th IEEE Conference on Decision and Control, San Diego, USA (2006, December)

In this paper we consider the question of parameter identifiability for biochemical reaction networks, as typically encountered in systems biology. Specifically, we are interested in deriving conditions ... [more ▼]

In this paper we consider the question of parameter identifiability for biochemical reaction networks, as typically encountered in systems biology. Specifically, we are interested in deriving conditions on the biochemical reaction network and on the measured outputs that guarantee identifiability of the parameters. Taking the specific system structure of biochemical reaction networks into account, we derive sufficient conditions for local parameter identifiability based on a suitable system expansion which does not any more directly depend on the parameters. Rather, as shown, the problem of identifiability can be recast as the question of observability of the (parameter free) expanded system. The conditions derived are exemplified considering a simple example [less ▲]

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See detailAn exceptional specimen of the early land plant Cooksonia paranensis, and a hypothesis on the life cycle of the earliest eutracheophytes
Gerrienne, Philippe ULg; Dilcher, D. L.; Bergamaschi, S. et al

in Review of Palaeobotany and Palynology (2006), 142(3-4), 123-130

An exceptionally large specimen of the early land plant Cooksonia paranensis Gerrienne et al. has been discovered from the type locality (Jackson de Figueiredo, Parana Basin, Brazil; early Lochkovian ... [more ▼]

An exceptionally large specimen of the early land plant Cooksonia paranensis Gerrienne et al. has been discovered from the type locality (Jackson de Figueiredo, Parana Basin, Brazil; early Lochkovian, Early Devonian). This nearly complete specimen consists of five dichotomous axes attached at their base to a small thalloid(?) structure. Each terminal axis segment ends in an expanded, cup-like, empty tip. Three interpretations of the specimen are proposed. (1) The whole specimen is a gametophyte of the Sciadopkyton-type, with a central area from which five axes depart; under this interpretation, the terminal cups are gametangiophores. (2) The basal structure represents the remains of a rhizome bearing five upright aerial axes, in which case the whole plant is a sporophyte. (3; our favoured hypothesis) The specimen is a cluster of five individual sporophytes still attached to the remains of a small female or bisexual gametophyte. In the latter case, this fossil is evidence that reduced thalloid gametophytes and branched axial sporophytes are plesiomorphic among the earliest eutracheophytes. We suggest that a major difference in life cycle defines a basal dichotomy in tracheophytes. Eutracheophyta, including all living vascular plants, have a heteromorphic, sporophyte dominant alternation of generations, whereas their extinct sister-group Rhymopsida (renamed here Paratracheophyta) is characterised by a more or less isomorphic alternations of generations. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailGeneralized Shape And Topology Optimization: Recent Developments And Application Perspectives To Automotive Structures
Duysinx, Pierre ULg; Van Miegroet, Laurent ULg; Remouchamps, Alain et al

in New Advances in Body Engineering - Lightweight design, passive safety, pedestrian protection, and numerical optimization (2006, December)

More than 15 years after the seminal work by Bendsøe and Kikuchi, topology optimization of structures has taken advantage of my research efforts and has now become a commercial available tool (e.g ... [more ▼]

More than 15 years after the seminal work by Bendsøe and Kikuchi, topology optimization of structures has taken advantage of my research efforts and has now become a commercial available tool (e.g. OptiStruct by Altair, Topol by Samtech, etc.). These software tools are daily used in automotive industry and provide engineers with a rational tool for preliminary design of efficient structural components. This paper presents the status of available topology optimization tools and introduces the recent developments that extend their capabilities in order to handle stress constraints, manufacturing constraints, etc. The communication also presents a novel approach of generalized shape optimization that has been introduced to circumvent the difficulties of parametric shape optimization and to complement topology optimization. The approach is based on the eXtended Finite Element Method (XFEM) and the Level Set Description of the geometry. The Level Set description introduces smooth curve descriptions and allows modifying the connectivity of the wholes. The XFEM works with a fixed mesh as in topology optimization, which makes the method very convenient for engineers. Thus the novel approach is likely to bring the next future evolution of structural optimization. Impressive capabilities of this new generation approach will be demonstrated. Application examples from automotive and aerospace engineering will illustrate the different possibilities offered by two approaches. [less ▲]

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See detailA contribution to the audit of an air-conditioning system: modeling, simulation and benchmarking
Adam, Christophe; Andre, Philippe ULg; Hannay, Cleide et al

(2006, December)

This paper intends to show how benchmarks can help in the audit of a HVAC system and how these benchmarks can be generated. The work presented is part of the European “AUDITAC” project. How can an auditor ... [more ▼]

This paper intends to show how benchmarks can help in the audit of a HVAC system and how these benchmarks can be generated. The work presented is part of the European “AUDITAC” project. How can an auditor declare that a given HVAC is “consuming too much”? He can’t make any judgment, if not having some reference, i.e. some “benchmarks” available. Focus is given here to cooling regime, but even then, heating cannot be forgotten (for example, the remaining heating demand can be satisfied thanks some recovery on the condensers of the chillers). The dramatic question is: what should be the consumption(s) for such a building, in such a climate, with such occupancy, such internal loads and such actual indoor environment? Better than to look for a (very hypothetical) global weather index, similar to heating degree-days, it seems more rational to run a simulation model on a few thousands of hours, corresponding to one (or to several) cooling season(s). Current performances of simulation tools make this approach very expedient. The climate can then be considered as it is, without any simplification. The main simplification is still welcome on the system (building + HVAC) side, in order to get calculation robustness, easy understanding and easy parameter identification. In this perspective, the building has to be subdivided in a very limited number of zones and only a few components of the HVAC system have to be included in the simulation model, with as simple as possible control strategies. [less ▲]

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See detailMolecular cloning and functional expression of a new aphid isoprenyl diphosphate synthase
Vandermoten, Sophie ULg; Beliveau, C.; Sen, S. et al

in Archives Internationales de Physiologie et de Biochimie (2006, December), 190

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