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See detailSurgical treatment of thoraco-abdominal and low thoracic aneurysms of the aorta. One single center experience over ten years
El Arid, J.-M.; CREEMERS, Etienne ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (2006), 106(6), 669-674

This work presents the results of surgery in thoraco-abdominal aortic aneurysms (TAA) and thoracic descending aortic aneurysms (TDA) in one single center between January 1rst, 1996 and December 31, 2005 ... [more ▼]

This work presents the results of surgery in thoraco-abdominal aortic aneurysms (TAA) and thoracic descending aortic aneurysms (TDA) in one single center between January 1rst, 1996 and December 31, 2005. It concerns open surgery in 42 and endovascular procedures in ten patients. Forty two patients (11 TDA and 31 TAA (4 type I, 12 type II, 6 type III and 9 type IV)) define the open surgery series. Twenty six patients were operated on elective basis and 16 patients in emergency condition. Surgical correction was made under partial cardio-pulmonary bypass (PCPB) in 70% of cases via femoral vessels; most significant intercostal arteries were reimplanted and cerebro-spinal fluid (CSF) drainage used in half of the cases. Operative mortality was zero in the elective group (0/26) and attained 19% in the emergent group (3/16). Mortality was linked to cerebrovascular accidents (CVA) in two cases and post-pump left lung hemorrhagic intarction in one case. The paraplegia accounts 2/26 in the elective group and one in the emergent group (1/16). That is 7.1% in both groups. At the end of five years, survival is 66% in elective group and 74% in the emergency group. Ten patients (5 TDA and 5 TAA (2 type I, 3 type III)) were treated endovascularly. Operative mortality and postoperative paraplegia were nil. [less ▲]

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See detailOn the understanding of the physical changes in inulin powder as a function of water activity.
Ronkart, Sébastien; Paquot, Michel ULg; Goffin, Dorothée ULg et al

Poster (2006, December)

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See detailThe in vitro influences of neurotensin on the motility characteristics of human U373 glioblastoma cells
Servotte, S.; Camby, I.; Debeir, O. et al

in Neuropathology & Applied Neurobiology (2006), 32(6), 575-584

Astrocytic tumours are associated with dismal prognoses due to their pronounced ability to diffusely invade the brain parenchyma. Various neuropeptides, including gastrin, are able to modulate tumour ... [more ▼]

Astrocytic tumours are associated with dismal prognoses due to their pronounced ability to diffusely invade the brain parenchyma. Various neuropeptides, including gastrin, are able to modulate tumour astrocyte migration. While neurotensin has been shown to influence the proliferation of glioma cells and the migratory ability of a large set of other cell types, its role in glioma cell migration has never been investigated. Neurotensin-induced modifications to the motility features of human U373 glioblastoma cells therefore constitute the topic of the present study. We evidenced that three subtypes of neurotensin receptors (NTR1, NTR2 and NTR3) are expressed in U373 glioblastoma cells, at least as far as their mRNAs are concerned. Treating U373 tumour cells with 10 nM neurotensin markedly modified the morphological patterns of these cells and also profoundly altered the organization of their actin cytoskeletons. Pull-down assays revealed that neurotensin induced the activation in U373 cells of both Rac1 and Cdc42 but not RhoA. Scratch wound assays evidenced that neurotensin (0.1 and 10 nM) very significantly inhibited wound colonization by U373 cells cultured in the absence of serum. In addition, quantitative phase-contrast videomicroscopy analyses showed that neurotensin decreases the motility levels of U373 glioblastoma cells when these cells are cultured on plastic. In sharp contrast, neurotensin stimulates the motility of U373 cells when they are cultured on laminin, which is a pro-adhesive extracellular matrix component ubiquitously secreted by glioma cells. Our data thus strongly suggest that, in addition to gastrin, neurotensin is a neuropeptide capable of modulating tumour astrocyte migration into the brain parenchyma. [less ▲]

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See detailBuilding EnCOrE : Encyclopédie de Chimie Organique Electronique
Colaux, Catherine ULg; Seleck, Caroline; Henry, Julie et al

Poster (2006, December)

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See detailSound field modeling in architectural acoustics using a diffusion equation
Picaut, Judicaël; Valeau, Vincent; Billon, Alexis ULg et al

Conference (2006, December)

A numerical approach is proposed to model the reverberated sound field in rooms. The model is based on the numerical implementation of a diffusion model enabling spatial variations of the sound energy ... [more ▼]

A numerical approach is proposed to model the reverberated sound field in rooms. The model is based on the numerical implementation of a diffusion model enabling spatial variations of the sound energy within a room, unlike the statistical theory. The proposed method allows to take into account most of complex phenomena encountered in room acoustics, like mixed reflections on walls (diffuse and specular), low and high absorption on walls, atmospheric attenuation, fitted zones. Moreover, the model can be applied to complex geometries, like multiple coupled rooms of different sizes. In this paper, the model and its numerical implementation are first detailed. Then, an application is proposed for a complex geometry defined by multiple coupled rooms with fitting objects, including low and high absorption on walls, in terms of sound level and reverberation times. The main interest of the model is that such approach requires less computational time in comparison with common approaches like ray-tracing simulations. [less ▲]

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See detailAdvances in immunoproteomics for serological characterization of microbial antigens
Falisse-Poirier, Nandini; Ruelle, Virginie ULg; Elmoualij, Benaïssa ULg et al

in Journal of Microbiological Methods (2006), 67(3), 593-596

We propose a multi-dimensional strategy, associating immunodetection to a protein fractionating two-dimensional liquid chromatography tool, for serological characterization of microbial antigens. The ... [more ▼]

We propose a multi-dimensional strategy, associating immunodetection to a protein fractionating two-dimensional liquid chromatography tool, for serological characterization of microbial antigens. The originality of such immunoproteomic approaches resides in their application in large-scale studies for rapid serotyping of micro-organisms, evaluation of immunomes and could be proposed in the development and monitoring of vaccines. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailSynthesis of block copolymers and their use for biomedical applications
Jérôme, Christine ULg

Conference (2006, December)

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See detailInferring Groups of Correlated Failures
Lepropre, Jean; Leduc, Guy ULg

Poster (2006, December)

We compare and evaluate different methods to infer groups of correlated failures. These methods try to group failure events occurring nearly simultaneously in clusters. Indeed if several failures occur ... [more ▼]

We compare and evaluate different methods to infer groups of correlated failures. These methods try to group failure events occurring nearly simultaneously in clusters. Indeed if several failures occur nearly at the same moment in a network, it is possible that these failures have the same root cause. The input data of our algorithms are IP failure notifications that can be provided by several sources. We consider two sources: IS-IS Link State Packets (LSPs) and Syslog messages. Our first results on the Abilene and GÉANT networks show that the inference methods behave differently and that using IS-IS LSPs provides more accurate results than using Syslog messages. [less ▲]

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See detailCost estimates of brain disorders in Belgium
Schoenen, Jean ULg; Gianni, F.; Schretlen, L. et al

in Acta Neurologica Belgica (2006), 106(4), 208-214

This article presents the data on cost of the major brain disorders in Belgium which were retrieved from "Cost of Disorders of the Brain in Europe" study sponsored by the European Brain Council and ... [more ▼]

This article presents the data on cost of the major brain disorders in Belgium which were retrieved from "Cost of Disorders of the Brain in Europe" study sponsored by the European Brain Council and performed by Stockholm Health Economics. The disorders selected were : addiction, depression, anxiety disorders, brain tumours, dementia, epilepsy, migraine and other headaches, multiple sclerosis, Parkinson's disease, psychotic disorders, stroke and trauma. Figures for prevalence of disorders and direct medical, direct non-medical and indirect costs are based on data coming from available electronic data bases, or when missing for Belgium, best possible estimates or extrapolated data were used. All economic data were transformed to E's for 2004 and adjusted for purchasing power parity (PPP). The results show that the total number of people with any brain disorder in Belgium amounts to 2,9 million in 2004, the most prevalent being anxiety disorders 1.1 million, migraine 860 000, addiction (any) 800.000 and depression 500.000 cases. The total cost of all included brain disorders in Belgium was estimated at 10.6 billion Euros. Most costly per case are brain tumours, multiple sclerosis, stroke and dementia. Because of their higher prevalence, however, depression, dementia, addiction, anxiety disorders and migraine have the highest total costs. Taken together, brain disorders consume 4% of the gross national product and cost each citizen of Belgium E 1029 per year The drug costs for brain disorders constitute only 10% of the total drug market in Belgium, and only 4% of the total cost of brain disorders in Belgium. This should be compared to the cost estimates and to a previous study which showed that brain disorders are responsible for 35% of the total burden of all disorders in Europe. This study suggests therefore that the direct healthcare resources, including expenses for drug therapies, allocated to brain disorders in Belgium are not leveled to the indirect costs and burden of these disorders. A comparison with data available from a direct prospective study in demented Belgian patients suggests that the mathematical estimates presented here reflect quite accurately the real average cost for dementia, although there are large variations depending on disease severity. As, in addition, subjects with brain disorders face collateral costs which have not been taken into account and may vary between countries, it seems worthwhile to conduct, in cooperation with patients associations, a complementary survey in the Belgian ecosystem to establish the cost profile of representative patients for the major brain disorders. Such a survey is being organized by a task force of the Belgian Brain Council. [less ▲]

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See detailQuestions de didactique du français langue seconde (cycle de conf.)
Defays, Jean-Marc ULg

Scientific conference (2006, December)

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See detailTranscriptional regulation of the mouse doublecortin gene in differentiating neurons
Plumier, Jean-Christophe ULg; Muller, Marc ULg; Rogister, Bernard ULg et al

in International Journal of Developmental Neuroscience (2006, December), 24(8), 535

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See detailLe portrait dans Daguerréotypes d'Agnès Varda
Van Cauwenberge, Geneviève ULg

Conference (2006, December)

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See detail"Er war ein Verlorener". Géza von Cziffra erinnert sich an Joseph Roth
Küpper, Achim ULg

in Literaturkritik.de (2006)

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See detailGeneralized Shape And Topology Optimization: Recent Developments And Application Perspectives To Automotive Structures
Duysinx, Pierre ULg; Van Miegroet, Laurent ULg; Remouchamps, Alain et al

in New Advances in Body Engineering - Lightweight design, passive safety, pedestrian protection, and numerical optimization (2006, December)

More than 15 years after the seminal work by Bendsøe and Kikuchi, topology optimization of structures has taken advantage of my research efforts and has now become a commercial available tool (e.g ... [more ▼]

More than 15 years after the seminal work by Bendsøe and Kikuchi, topology optimization of structures has taken advantage of my research efforts and has now become a commercial available tool (e.g. OptiStruct by Altair, Topol by Samtech, etc.). These software tools are daily used in automotive industry and provide engineers with a rational tool for preliminary design of efficient structural components. This paper presents the status of available topology optimization tools and introduces the recent developments that extend their capabilities in order to handle stress constraints, manufacturing constraints, etc. The communication also presents a novel approach of generalized shape optimization that has been introduced to circumvent the difficulties of parametric shape optimization and to complement topology optimization. The approach is based on the eXtended Finite Element Method (XFEM) and the Level Set Description of the geometry. The Level Set description introduces smooth curve descriptions and allows modifying the connectivity of the wholes. The XFEM works with a fixed mesh as in topology optimization, which makes the method very convenient for engineers. Thus the novel approach is likely to bring the next future evolution of structural optimization. Impressive capabilities of this new generation approach will be demonstrated. Application examples from automotive and aerospace engineering will illustrate the different possibilities offered by two approaches. [less ▲]

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See detailPromotion de la santé à l'école ... Les modifications tant attendues de deux décrets
Vandoorne, Chantal ULg

in Education Santé (2006), (218), 7-8

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See detailHigh prevalence of pituitary adenomas: A cross-sectional study in the province of Liege, Belgium
Daly, Adrian ULg; Rixhon, M.; Adam, Christelle et al

in Journal of Clinical Endocrinology and Metabolism (2006), 91(12), 4769-4775

Context: Prevalence data are important for assessing the burden of disease on the health care system; data on pituitary adenoma prevalence are very scarce. Objective: The objective of the study was to ... [more ▼]

Context: Prevalence data are important for assessing the burden of disease on the health care system; data on pituitary adenoma prevalence are very scarce. Objective: The objective of the study was to measure the prevalence of clinically relevant pituitary adenomas in a well-defined population. Design: This was a cross-sectional, intensive, case-finding study performed in three regions of the province of Liège, Belgium, to measure pituitary adenoma prevalence as of September 30, 2005. Setting: The study was conducted in specialist and general medical practitioner patient populations, referral hospitals, and investigational centers. Methods: Three demographically and geographically distinct districts of the province of Liège were delineated precisely using postal codes. Medical practitioners in these districts were recruited, and patients with pituitary adenomas under their care were identified. Diagnoses were confirmed after retrieval of clinical, hormonal, radiological, and pathological data; full demographic and therapeutic follow-up data were collected in all cases. Results: Sixty-eight patients with clinically relevant pituitary adenomas were identified in a population of 71,972 individuals; the mean (± SD) prevalence was 94 ± 19.3 cases per 100,000 population (95% confidence interval, 72.2 to 115.8). The group was 67.6% female and had a mean age at diagnosis of 40.3 yr; 42.6% had macroadenomas and 55.9% underwent surgery. Prolactinomas comprised 66% of the group, with the rest having nonsecreting tumors (14.7%), somatotropinomas (13.2%), or Cushing’s disease (5.9%); 20.6% had hypopituitarism. Conclusion: The prevalence of pituitary adenomas in the study population (one case in 1064 individuals) was more than 3.5–5 times that previously reported. This increased prevalence may have important implications when prioritizing funding for research and treatment of pituitary adenomas. [less ▲]

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