References of "2006"
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See detailBuilding EnCOrE : Encyclopédie de Chimie Organique Electronique
Colaux, Catherine ULg; Seleck, Caroline; Henry, Julie et al

Poster (2006, December)

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See detailEnCOrE : Encyclopédie de Chimie Organique Electronique
Colaux, Catherine ULg; krief, Alain

Poster (2006, December)

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See detailLa radiothérapie du cancer du sein
Meyns, Mia ULg

in AIDS Patient Care (2006), 4

Le traitement du cancer du sein est un des exemples les plus probants de l'approche multidisciplinaire oncologique. Dans ce contexte, la radiothérapie a renforcé sa place et son importance, même si ... [more ▼]

Le traitement du cancer du sein est un des exemples les plus probants de l'approche multidisciplinaire oncologique. Dans ce contexte, la radiothérapie a renforcé sa place et son importance, même si certaines incertitudes persistent, comme la prise en charge du creux axillaire, de la chaîne mammaire interne et de la paroi thoracique. La tendance constatée depuis plusieurs années est celle d'une approche moins agressive. [less ▲]

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See detailRetarder la sclérose osseuse.
Henrotin, Yves ULg

Article for general public (2006)

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See detail18f-Fdg Pet Imaging in Assessing Exudative Pleural Effusions
DUYSINX, Bernard ULg; Larock, Marie-Paule ULg; Nguyen, Delphine et al

in Nuclear Medicine Communications (2006), 27(12), 971-6

BACKGROUND: This study evaluates the accuracy of [F]fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging with semi-quantitative analysis for differentiating benign from malignant pleural ... [more ▼]

BACKGROUND: This study evaluates the accuracy of [F]fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging with semi-quantitative analysis for differentiating benign from malignant pleural exudates and for guiding the search for the primary tumour of pleural metastases. METHODS: Whole-body 18F-FDG PET was performed in 79 patients with exudative pleurisy. Standard uptake values were normalized for body weight, body surface area, lean body mass (SUVbw, SUVbsa, SUVlbm) with and without correction for blood glucose levels. Thoracoscopy was systematically performed to reveal pathological diagnosis. RESULTS: All SUVs were significantly higher in all malignant pleural diseases (n = 51) than in benign (n = 28) (P < 0.001). Moreover SUVs were greater in the pleural metastases from pulmonary primaries (n = 25) and in mesotheliomas (n = 8) than in extrathoracic primaries (n = 18) (P < 0.01) with no significant difference between lung cancers and mesotheliomas. Receiver operating curve (ROC) analysis between benign and malignant lesions showed areas under the curves that ranged from 0.803 (SUVbsa g) to 0.863 (SUVbw). The cut-off value for SUVbw which gave the best accuracy (82.3%) was 2.2. When comparing thoracic with extrathoracic primaries the highest accuracy (80.4%) was found for a cut-off value of 2.6. CONCLUSION: Semi-quantitative analysis of 18F-FDG PET imaging helps to differentiate malignant from benign pleural exudates and to distinguish between thoracic or extrathoracic primaries. [less ▲]

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See detailThe in vitro influences of neurotensin on the motility characteristics of human U373 glioblastoma cells
Servotte, S.; Camby, I.; Debeir, O. et al

in Neuropathology & Applied Neurobiology (2006), 32(6), 575-584

Astrocytic tumours are associated with dismal prognoses due to their pronounced ability to diffusely invade the brain parenchyma. Various neuropeptides, including gastrin, are able to modulate tumour ... [more ▼]

Astrocytic tumours are associated with dismal prognoses due to their pronounced ability to diffusely invade the brain parenchyma. Various neuropeptides, including gastrin, are able to modulate tumour astrocyte migration. While neurotensin has been shown to influence the proliferation of glioma cells and the migratory ability of a large set of other cell types, its role in glioma cell migration has never been investigated. Neurotensin-induced modifications to the motility features of human U373 glioblastoma cells therefore constitute the topic of the present study. We evidenced that three subtypes of neurotensin receptors (NTR1, NTR2 and NTR3) are expressed in U373 glioblastoma cells, at least as far as their mRNAs are concerned. Treating U373 tumour cells with 10 nM neurotensin markedly modified the morphological patterns of these cells and also profoundly altered the organization of their actin cytoskeletons. Pull-down assays revealed that neurotensin induced the activation in U373 cells of both Rac1 and Cdc42 but not RhoA. Scratch wound assays evidenced that neurotensin (0.1 and 10 nM) very significantly inhibited wound colonization by U373 cells cultured in the absence of serum. In addition, quantitative phase-contrast videomicroscopy analyses showed that neurotensin decreases the motility levels of U373 glioblastoma cells when these cells are cultured on plastic. In sharp contrast, neurotensin stimulates the motility of U373 cells when they are cultured on laminin, which is a pro-adhesive extracellular matrix component ubiquitously secreted by glioma cells. Our data thus strongly suggest that, in addition to gastrin, neurotensin is a neuropeptide capable of modulating tumour astrocyte migration into the brain parenchyma. [less ▲]

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See detailPredictable disruption tolerant networks and delivery guarantees
François, Jean-Marc; Leduc, Guy ULg

Report (2006)

This article studies disruption tolerant networks (DTNs) where each node knows the probabilistic distribution of contacts with other nodes. It proposes a framework that allows one to formalize the ... [more ▼]

This article studies disruption tolerant networks (DTNs) where each node knows the probabilistic distribution of contacts with other nodes. It proposes a framework that allows one to formalize the behaviour of such a network. It generalizes extreme cases that have been studied before where (a) either nodes only know their contact frequency with each other or (b) they have a perfect knowledge of who meets who and when. This paper then gives an example of how this framework can be used; it shows how one can find a packet forwarding algorithm optimized to meet the 'delay/bandwidth consumption' trade-off: packets are duplicated so as to (statistically) guarantee a given delay or delivery probability, but not too much so as to reduce the bandwidth, energy, and memory consumption. [less ▲]

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See detailSound field modeling in architectural acoustics using a diffusion equation
Picaut, Judicaël; Valeau, Vincent; Billon, Alexis ULg et al

Conference (2006, December)

A numerical approach is proposed to model the reverberated sound field in rooms. The model is based on the numerical implementation of a diffusion model enabling spatial variations of the sound energy ... [more ▼]

A numerical approach is proposed to model the reverberated sound field in rooms. The model is based on the numerical implementation of a diffusion model enabling spatial variations of the sound energy within a room, unlike the statistical theory. The proposed method allows to take into account most of complex phenomena encountered in room acoustics, like mixed reflections on walls (diffuse and specular), low and high absorption on walls, atmospheric attenuation, fitted zones. Moreover, the model can be applied to complex geometries, like multiple coupled rooms of different sizes. In this paper, the model and its numerical implementation are first detailed. Then, an application is proposed for a complex geometry defined by multiple coupled rooms with fitting objects, including low and high absorption on walls, in terms of sound level and reverberation times. The main interest of the model is that such approach requires less computational time in comparison with common approaches like ray-tracing simulations. [less ▲]

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See detailA 2.5-Mb contig constructed from Angus, Longhorn and horned Hereford DNA spanning the polled interval on bovine chromosome 1
Wunderlich, K. R.; Abbey, C. A.; Clayton, D. R. et al

in Animal Genetics (2006), 37(6), 592-594

The polled locus has been mapped by genetic linkage analysis to the proximal region of bovine chromosome 1. As an intermediate step in our efforts to identify the polled locus and the underlying causative ... [more ▼]

The polled locus has been mapped by genetic linkage analysis to the proximal region of bovine chromosome 1. As an intermediate step in our efforts to identify the polled locus and the underlying causative mutation for the polled phenotype, we have constructed a BAC-based physical map of the interval containing the polled locus. Clones containing genes and markers in the critical interval were isolated from the TAMBT (constructed from Angus and Longhorn genomic DNA) and CHORI-240 (constructed from horned Hereford genomic DNA) BAC libraries and ordered based on fingerprinting and the presence or absence of 80 STS markers. A single contig spanning 2.5 Mb was assembled. Comparison of the physical order of STSs to the corresponding region of human chromosome 21 revealed the same order of genes within the polled critical interval. This contig of overlapping BAC clones from horned and polled breeds is a useful resource for SNP discovery and characterization of positional candidate genes. [less ▲]

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See detailBulletin de la Société Voltaire n°12
Tilkin, Françoise ULg

E-print/Working paper (2006)

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See detailLe portrait dans Daguerréotypes d'Agnès Varda
Van Cauwenberge, Geneviève ULg

Conference (2006, December)

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See detailPreface: A tribute to Muriel Fairon-Demaret
Gerrienne, Philippe ULg

in Review of Palaeobotany and Palynology (2006), 142(3-4), 61-61

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See detailGeneralized Shape And Topology Optimization: Recent Developments And Application Perspectives To Automotive Structures
Duysinx, Pierre ULg; Van Miegroet, Laurent ULg; Remouchamps, Alain et al

in New Advances in Body Engineering - Lightweight design, passive safety, pedestrian protection, and numerical optimization (2006, December)

More than 15 years after the seminal work by Bendsøe and Kikuchi, topology optimization of structures has taken advantage of my research efforts and has now become a commercial available tool (e.g ... [more ▼]

More than 15 years after the seminal work by Bendsøe and Kikuchi, topology optimization of structures has taken advantage of my research efforts and has now become a commercial available tool (e.g. OptiStruct by Altair, Topol by Samtech, etc.). These software tools are daily used in automotive industry and provide engineers with a rational tool for preliminary design of efficient structural components. This paper presents the status of available topology optimization tools and introduces the recent developments that extend their capabilities in order to handle stress constraints, manufacturing constraints, etc. The communication also presents a novel approach of generalized shape optimization that has been introduced to circumvent the difficulties of parametric shape optimization and to complement topology optimization. The approach is based on the eXtended Finite Element Method (XFEM) and the Level Set Description of the geometry. The Level Set description introduces smooth curve descriptions and allows modifying the connectivity of the wholes. The XFEM works with a fixed mesh as in topology optimization, which makes the method very convenient for engineers. Thus the novel approach is likely to bring the next future evolution of structural optimization. Impressive capabilities of this new generation approach will be demonstrated. Application examples from automotive and aerospace engineering will illustrate the different possibilities offered by two approaches. [less ▲]

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See detailMolecular cloning and functional expression of a new aphid isoprenyl diphosphate synthase
Vandermoten, Sophie ULg; Beliveau, C.; Sen, S. et al

in Archives Internationales de Physiologie et de Biochimie (2006, December), 190

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See detailApplication of MRI for improved local control in complex radiotherapy of cervical cancer
Janaki, Hadjiev; Zsolt, Cselik; Péter Bogner et al

in Archive of Oncology (2006), 14(3-4), 95-100

Background: The aim of this study was to analyze the use of magnetic resonance imaging (MRI) as a modern medical imaging technique in radiotherapy with special emphasis on the integration of MRI and a ... [more ▼]

Background: The aim of this study was to analyze the use of magnetic resonance imaging (MRI) as a modern medical imaging technique in radiotherapy with special emphasis on the integration of MRI and a novel technique in brachytherapy to optimize treatment outcome in cervical cancer. Methods: In addition to the CT based shrinking volume conformal teletherapy in 31 patients with locally advanced cervical cancer, MRI examination with a special adjustable applicator at the treatment site was performed for the brachytherapy planning. To avoid excessive doses to the healthy structures during complex cervical radiotherapy isodose curves were calculated upon the information of the MR image and dose distribution was evaluated. Results: The consecutive application of CT and MRI limited the possibility for overdosage of the critical organs and undertreatment of the advanced tumor spread in all cases. The overall response rate for the complex treatment was 74.2% with complete regression in 25.8% of the cases. Based on the exact information of the three dimensional digital data radiation doses could be optimized without increasing the possibility of acute complications rate. Conclusion: The introduction of 3D treatment planning for teletherapy pelvic and boost irradiation of cervical carcinoma as well as for the brachytherapy part of the complex treatment is to be recommended. [less ▲]

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See detailLe cas clinique du mois. Syndrome malin des neuroleptiques et paralysie generale
Foatelli, F. M.; gernay, p; Lievens, Isabelle ULg et al

in Revue Médicale de Liège (2006), 61(12), 807-11

Described in 1960 by Jean Delay in relation to the use of haloperidol, neuroleptic malignant syndrome remains relatively rare, and poorly known by the medical profession. The emergence of the atypical ... [more ▼]

Described in 1960 by Jean Delay in relation to the use of haloperidol, neuroleptic malignant syndrome remains relatively rare, and poorly known by the medical profession. The emergence of the atypical antipsychotic agents and preventive measures which have become general in recent years in hospital departments using dopamine receptor antagonists has not altered the prognosis, which remains potentially fatal in approximately a quarter of cases. This article proposes a descriptive summary of this syndrome in terms of clinical and biological diagnostics as well as of evolution, epidemiology, differential diagnosis and treatment. It describes the case of a patient affected by general paralysis having developed a neuroleptic malignant syndrome, thus the hypothesis what the neuroleptic malignant syndrome preferentially arises in subjects having underlying organic or metabolic problems and provides food for thought regarding the main medical and psychiatric overlaps, the use of dopaminergic agents and the behaviour to be adopted when dealing with a patient presenting with inaugural psychiatric symptomatology. [less ▲]

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